Gene MTMR9 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR9
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP034_AA protein Get Run
AqueP034_AA_124-503 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR9_pd Subfamily MTMR9 110-498 3.4e-165 541.9 In-house 1-392 (393) alignment 
Range on Protein: 110-498
Range on HMM: 1-392/393.0
PFFFRPRIPPSDIpPFSPENMTSLFTRYKCPPDDWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLCG
|||.|. .  ..   .|  .    |...... |.||.|..|...|.|.|.||.||.|..|.|.|..|.|.||..|.||.|||.......|.||...||||
pffyrsvatiled.gysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcg

TTLKRCKEDIKLLNSCLKIG-KGRIFDIRTQQAAQHHMSKGGGVEFPSNYSQWRVEYGSMESITNIQSSYLKLIDVCSD--VNNSSWYGRLESSGWLTHV
.. |||||| ||||..|| . || |.|.|...||....|||||.|. ..||||. .. |.||...||.|. ||...|||  ....... |||.||||..|
ssgkrckedekllnlvlkklkkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqv

EQLLRAVKHVVHSVYQEGTSVVLHGTNGCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVSAAP--EKQKGPIFLLFLDAVWQIM
..||.|...|......||..||.||..|.| ||||.|||.|..||.|||.||| .||||||.|.||||. |.. |.|..  .|..||.||||||.|.||.
adlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqil

RQYPLSFEFNELLLHILFVHSYSSSYGTFLYDNPAERDRHKLREKTESLWDYIlLSPDVMSSIINPLYSKNSTLLVVSVHPCSIVFWKRLYLRT
.|.|.|||||| ||..|| |||||..||||.|| |||...||..||.|||.|.  .|.......||||..|......||.|.|...|..||||.
sqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyv.nrpeklkqflnplyeanaeviwpsvapqslelWselylrw
0040695 (Phosphotyrosine protein) phosphatases II 134-498 6.5e-111 364.6 In-house 17-385 (388) alignment 
Range on Protein: 134-498
Range on HMM: 17-385/388.0
FTRYKCPPDDWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLCGTTLKRCKEDIKLLNSCLK----IG
..|.... | ||.|..|..|.||.| |  ...|. |.|...  ||.||..|..|.|||....  .|.||...||.|..|.|..|| |||...||      
lkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleailkllpnls

KGRIFDIRTQQAAQHHMSKGGGVEFPSNYSQWRVEYGSMESITNIQSSYLKLIDVCSDVN-NSSWYGRLESSGWLTHVEQLLRAVKHVVHSVYQEGTSVV
|. |.| |    |.  . .|||||. ..|..... . ....| ....|. ||.|.|  |   .... .||.|||| .. ..|.... .|. . ....||.
kllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllslleesgwldliklilelavlivklldlgnssvl

LHGTNGCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVS-AAPEKQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYS
.|...| | | |.|||| ||.||  ||..||. |||.|||. ||.|. |....      |.  |.||||||.|||..||.|..||||| ||. |. |.||
vhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlys

SSYGTFLYDNPAERDRHKLREKTESLWDYILLSPDVmssIINPLYSKNST-LLVVSVHPCSIVFWKRLYLRT
. .||||.... || .....|.| |||.|.|   ..    .||||. .|. .|..|........|  .|||.
crfgtFlfnsekerlelsvsertlslwsyllsrkse...flnplYdpsslevllpslsvldlllWleyylrw
Myotub-related Myotubularin-like phosphatase domain 134-442 8e-102 333.6 Pfam-A 30-351 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 134-442 8e-102 333.6 In-house 30-351 (353) alignment
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 134-498 3.3e-97 318.2 In-house 25-402 (404) alignment 
Range on Protein: 134-498
Range on HMM: 25-402/404.0
FTRYKCPPD-DWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLCGTTLKRCKEDIKLLNSCLK----I
..| . . . .||.|..|  |.||.. |. ...| .|.|.|.  |||||..|..|.||. . ...|.| |.  || | | .|..|| ||.||  |     
ykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirkaktql

GKGRIFDIRTQQAAQHHMSKGGGVEFPSNYSQWRVEYGSMESITNIQSSYLKLIDVCSDVNNS--SWYGRLESSGWLTHVEQLLRAVKHVVHSVYQEGTS
 .  | |.|... | .  .|| |.|  |.|..  .|  ..| | ... |. || .........   |. .||||.|| |...||...|..|... .|..|
etlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekss

VVLHGTNGCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVSAAPEKQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSY
|..|  .| | | |.|||. ||.||  |||.||  |||.|||. || |  |..  .   .... |||| |.|.|.|...|.| |||||| .|  .  ..|
vlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildaly

SSSYGTFLYDNPAERDRHKLREKTESLWDYIllSPDVmSSIINPLYSKNSTL----LVVSV-----HPCSIVFWKRLYLRT
|. .||||||.  || ...| ..| ||| ..  . .  |. .|||| ....        |      ..  | .|. .||| 
scrfgtFLydsekeRqqnnlaketvslWall..eank.seylnplyilekkeqkenitssessssadikliklWseyylrw
subfamily_MTMR1_pd Subfamily MTMR1 136-499 5.9e-94 307.5 In-house 18-387 (389) alignment 
Range on Protein: 136-499
Range on HMM: 18-387/389.0
RYKCPPD-DWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLCGTTLKRCKEDIKLLNSCLKIGKGR--
|   . .  ||... |. |.|| ..|. ...|. ..|...  ||.||..|..|.||..| ....||||. .|| |.. ||.||| |.|.  |.  . .  
rlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqaileanaqsek

--IFDIRTQQAAQHHMSKGGGVEFPSNYSQWRVEYGSMESITNIQSSYLKLIDVCS-DVNNSSWYGRLESSGWLTHVEQLLRAVKHVVHSVYQEGTSVVL
  |.| |.. .|..   ||.| |  ..| . .. .  ...|  .. |. || ...  .|....|.  |||. || |....|..  ..|..| .| |||..
llildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekvetektsvlv

HGTNGCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVS-AAPEKQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYSS
| ..| | | |. ||| ||.|.  |||.||  |||.|||. ||.|. |.        .....|.|| |.|.|||..||.|  ||||| .| .|  |.||.
hcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysc

SYGTFLYDNPAERDRHKLREKTESLWDYILLSpdvMSSIINPLYSKN--STLLVVSVHPCSIVFWKRLYLRTD
 .||||... .|| ..|. ||| ||| |.  |   ... .||||...  ...|.. .  ...  ||. ||| .
lfGtflfnsekervkekvkektvslwsyvnss...keeftnplyaeelekkvlypkaslrrlelWkeyylrwn
subfamily_MTMR6_pd Subfamily MTMR6 131-499 5.9e-87 284.5 In-house 25-396 (397) alignment 
Range on Protein: 131-499
Range on HMM: 25-396/397.0
TSLFTRYKCPPDDWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLCGTTLkRCKEDIKLLNSCLKIGK
.. .||   | . | ..|.|. |.||...|.|. .|.... . . . . || .|..|.|||.  .... | || .||.| .  ||.|| |||.   |   
kaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa.rcledeklleairkanp

G----RIFDIRTQQAAQHHMSKGGGVEFPSNYSQWRVEYGSMESITNIQSSYLKLIDVCSDV--NNSSWYGRLESSGWLTHVEQLLRAVKHVVHSVYQEG
      . | | .  |    ..| | |  .|||  . .. ..| |  ...|  ||..|.     . |...  ||||||| |....| |   . ..|..||
nsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeeg

TSVVLHGTNGCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVSAApEKQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVH
.||..| ..| | | || ||| ||.||  |||.||| |||.|||  || || |   .. . .|.  |||. ||..|||...|.| .|||||  |  |  |
asvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGllded.skevsPiftqflecvwqlleqfpkafefnerfllelhdh

SYSSSYGTFLYDNPAERDRHKLREKTESLWDYILlspDVMSSIINPLYSKNST--LLVVSVHPCSIVFWKRLYLRTD
 ||. .|||| ..  .|  .||.|.|.||| |.|   .  .  .||||.....  .| ....|... .|. || | |
vyscqfGtflgncekdrrdlklkertkslwayll...erkddylnplykaetekevlkpdtapaalklwralynrfd
subfamily_MTMR3_pd Subfamily MTMR3 233-497 9e-66 215.4 In-house 177-441 (442) alignment 
Range on Protein: 233-497
Range on HMM: 177-441/442.0
IFDIRTQQAAQHHMSKGGGVEFPSNYSQWRVEYGSMESITNIQSSYLKLIDVCSDVNN-SSWYGRLESSGWLTHVEQLLRAVKHVVHSVYQEGTSVVLHG
| |.|.  ||    .||||.| .  |..  |.. ..  |  ...|. .|  ..|. .. | |...||.  || .. .||.|  .||..| .|| .|..| 
ivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhC

TNGCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVSAAPE-KQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYSSSY
..| | | |. .|| ||.||  ||..||  |.|||||. || |. |    .   . ... |.|| .|||| |. ||.| ||||||  |  |  |.||. .
sdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclf

GTFLYDNPAERDRHKLREKTESLWDYILLSpdvMSSIINPLYSKN-STLLVVSVHPCSIVFWKRLYLR
|||| ..  || ..|..|.| |.|...  .     .. | ||... ...|...|.  .. .|. .|| 
GtflansekereeekvkertlsvWsllrak...ekeyrnllykekteavllpavsvrelklwsevyle
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 143-497 1.8e-57 186.9 In-house 41-403 (405) alignment 
Range on Protein: 143-497
Range on HMM: 41-403/405.0
DWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLCGTTLKRCKEDiKLLNSCLKIGKG----RIFDIRT
 |.|.. |. ||.|||..  ... .|  |...  . ||| .|. | ||. . .  . | || .|| |    || || .|  | | .        . | | 
ywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcped.elycsslalsapsktlylidarp

QQAAQHHMSKGGGVEFPSNYSQWRVEYGSMESITNIQSSYLKLIDVCS---------DVNNSSWYGRLESSGWLTHVEQLLRAVKHVVHSVyQEGTSVVL
.  |    ..| |.|   || . .. .  .  |  |. |  ||.             .  .  ..| .| .||..|.  .| |     . .   | |...
klnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilv

HGTNGCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVSAApEKQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYSSS
| ..| | | |..||. .|.||  ||| ||  |||.|||  || ||||   .    |... |||  |||...|.. |.|| |||   || ..    .|  
hcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgn.eeerspifqqfldccfqllsqfpllfeftpslllfisdnihsck

YGTFLYDNPAERDRHKLREKTESLWDYILLSpdvMSSIINPLYSKNSTL-LVVSVHPCSIVFWKRLYLR
||||| .   .| ..... || |.|  . |    .  ..|| |  .    .   ..   . .||  |.|
ygtflnncekdrvqdqvktktisiwsevnln...vnkflnpyynpqdiqsikpklysrclelwkacymr
subfamily_MTMR10_pd Subfamily MTMR10 142-447 1.6e-53 173.9 In-house 24-308 (380) alignment 
Range on Protein: 142-447
Range on HMM: 24-308/380.0
DDWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSViLRCGEPlcGTTLKRCKEDIKLLN-SCLKIGKGRifdirtqq
| ..|.  |   . . . |. ...|....|...  .    . ..||....  .| ... ||...   ... .  ||...  . .  |   ..        
daivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaal.lrlsal..qeaesadkekeekmlelvrkchpan........

aaqhhmskgggvefpsnYSQWRVEYGSMESITNIQSSYLKLIDVCSDVNN-------SSWYGRLESSGWLTHVEQLLRAVKHVVHSVYQEGTSVVLHGTN
                   . .    ...|| ..|..||||  .|   .          |.. ||...||  |. .|. .  .|. |.....||.|   .
.................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqese

GCDGTLQVSSLAILLMDPQARTIRGFLQLIEREWLQGGHPFSLRHNIVSAAPEKQKgPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYSSSYGTF
| |  . |.||| |..||  |||.|| .||..||  .||||  | . .  ...... |.|||||| |.| ..|.| .|||.| .|  |. .|.|. ..||
grDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpsekses.pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltf

LYDNPAERDRHKLR
| .....| ...  
lfnseeqrlkavvs
subfamily_MTMR5_pd Subfamily MTMR5 269-492 8.9e-48 155.3 In-house 236-476 (483) alignment 
Range on Protein: 269-492
Range on HMM: 236-476/483.0
ESITNIQSSYLKLIDVCSDVNN------SSWYGRLESSGWLTHVEQLLRAVKHVVHSVYQEGTSVVLHGTNGCDGTLQVSSLAILLMDPQARTIRGFLQL
  | ....|. ||. .|.  ..      .|..  .| | ||. ...||.    ||  .  .| ||..   .| | | |||||| ||.||  ||. ||  |
veirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvL

IEREWLQGGHPFSLRHNIVSAAPEKQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYSSSYGTFLYDNPAERDRHKL--------REK--TES
.|.|||  || |. | | . .| .    |.|| |||.|.|..||.||.||||.  |..|  || |  . |||.|   ||  . |        |.|  ..|
veKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagks

LWDYILLSPDVMSSIINPLYSK-NSTLLVVSVHPCSIVFWK
.||||     . .   | |||. .|. |  |..  |.  |.
vwdyidrqhkrspifynflyspdesevlrPssnvsslkvWd
subfamily_pats1_pd Subfamily pats1 390-475 1.2e-21 68.7 In-house 553-635 (691) alignment 
Range on Protein: 390-475
Range on HMM: 553-635/691.0
GPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYSSSYGTFLYDNPAERDRHKLREKTESLWDYILlspDVMSSIINPLYSKN
 |||. |||.|||. ...|. ||||| || .|  .|.|| .|.|||..  ..  .|. ....|.| .|       |  || || . 
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfin...qnksrfinllykhs
subfamily_MTMR3_pd Subfamily MTMR3 142-227 5.5e-21 67.8 In-house 42-127 (442) alignment 
Range on Protein: 142-227
Range on HMM: 42-127/442.0
DDWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLCGTTLKRCKEDIKLLNSCLK
. ||.|| |  .|||||.|...|.|..|.|...  |||||  ...| . .   |...|. ||. |  |    |..|| |||..  |
eawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaiak
subfamily_pats1_pd Subfamily pats1 263-377 9e-18 56.0 In-house 338-456 (691) alignment 
Range on Protein: 263-377
Range on HMM: 338-456/691.0
VEYGSMESITNIQSSYLKLIDVCS--DVNNSSWyGRLESSGWLTHVEQLLRAVKHVVHSVyQEGTSVVLHG-TNGCDGTLQV---SSLAILLMDPQARTI
... |. .  ...  . .|..     | ... |   .| | |.  |  || |. .|   .  ||.||.|.  ... . .|..   |||| .|.||  ||.
iiflslPtrekveerffdllqsilsldgsddew.keieeskwvdsvkllleaavkvsnll.deGssvllknsidsPlieldlasisslaqvlsdPfyrtl

RGFLQLIEREWLQGGHPFSLR
 ||. |||.|||. |.||| .
dGfkvliekewlsyGfPfski
subfamily_MTMR5_pd Subfamily MTMR5 142-206 3.5e-13 41.2 In-house 29-93 (483) alignment 
Range on Protein: 142-206
Range on HMM: 29-93/483.0
DDWRVSDCNRGYKLCSSHPEEVIIPAKINDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEP
...|.|  |. |..| | |  ...| ...|..|  ||   .....|.  . .........| |..
gkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_pats1_pd Subfamily pats1 142-202 2.8e-07 21.3 In-house 23-82 (691) alignment 
Range on Protein: 142-202
Range on HMM: 23-82/691.0
D-DWRVSDCNRgYKLCSSHPEEVIIPAKINDQEIGAVASFRQHgKFPILSYYNSKQRSVILR
| |||| .  .  .|.  .|. ...|  . |. . . .  |.. |.|.||. | ...|...|
dkdwrvvefls.rdlseiyPkrilvPklvsdellvsyvrkrss.kiPvlswsnqnnksslfr