Gene PTPRB in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP061_AA protein Get Run
AqueP061_AA_863-1137 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 857-1141 4.1e-135 444.5 In-house 3-290 (293) alignment 
Range on Protein: 857-1141
Range on HMM: 3-290/293.0
NSRKVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGP
.|... |..| ..|..| .|. ..||||||...||| |....|. |..|||||||||||.||||||||....||.|||||||||||||...| .||||||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA-QPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPAL
||.|.||||||.||..|..|||||||||.|..||..|||   .| .||.|.|....|.|..||..|..||.|||..|....|.|.||||||||... . |
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

DFVREVHEVA--SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSMS
||||.|.|..  ... .|..|||||||||||||||| .|||.|...|.||.||. .|.|..||...||| ||.|||....| ......
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_PTPRD_pd Subfamily PTPRD 860-1138 6.4e-125 412.9 In-house 4-283 (564) alignment 
Range on Protein: 860-1138
Range on HMM: 4-283/564.0
KVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVgLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPS
..   .....|. .  . ..||.|||.|..     ....|.  |.|.||||| ||.|||||||.|.... ..|||||||..| ||| |.|||||||||..
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDF
|..||||| |||||..|||||.|.|.|..|||.|||  ..| |||. |.. .|.|..| ..|.||..|  .. ||......|.||||||||..| . ||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

VREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
.|.|......  ||..||||||||||||||..  .|. ||. . ||...  ...|..||.|.||| ||.|||.|...| ..
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 863-1139 1.9e-113 373.7 In-house 4-283 (318) alignment 
Range on Protein: 863-1139
Range on HMM: 4-283/318.0
LRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFD
..|. | |. . ..   ..|||||..| .    ..  || | |.|||||.|||||||.||||. ...|.||||||||||.||| ..||||.|.||| |..
vedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVRE
||||| ||||| |||||||..|||..|.|||||. ... ||.. |.. .|.| ||...|.||.|.  |. ||..  |.. ||||.|||....  ||.||.
DfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq

VHEVA-SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
|...  .|  ||..|||||||||||.|||. .||..||.   ||.|.  ...|..|| |.||| ||.||......| .| 
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
0051299 (Phosphotyrosine protein) phosphatases II 860-1136 1.8e-106 351.1 In-house 4-286 (288) alignment 
Range on Protein: 860-1136
Range on HMM: 4-286/288.0
KVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPS
 . .... ..|. .| .   .. ||.|.. ..  |..  |.|||||. ||||..||.|||||||| ..|...|||||||.||.||.. |..||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT------KEKRSRTITHYQFVSWPDHGVPDEAGP
|..||||| ||||..||||||.|||.||.||..|||  ....||.| | .|||....|..||....|      ... |||.||... .|||||||| . .
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

ALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
 |||.|.|... .|  |||.|||||||||||||||| .||.... . .||....   .|..|..|.||. ||.|...|.....
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 854-1139 8.8e-104 342.4 In-house 19-302 (308) alignment 
Range on Protein: 854-1139
Range on HMM: 19-302/308.0
ATPNSRKVYLRDFPSYVEDmlNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLesiddEPGSDYINANYIPGY--RMRRAYI
 ...| |... |.  ..|.   .   ...||.|.. .|  ... ...|||||. ||||..||.||||||||     ..|||||||.|..||  . .|..|
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfI

ATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA---QPEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHG
|||||||.|..||||| ||||..||||||.|||.|| ||..|||     ....|| . | .|||....|..||....|.  .. |||.||... .|||||
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhg

VPDEAGPALDFVREVHEVASSafGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
||... . |||...|... ..  ||..|||||||||||||||| .||.... . .||.|..   .|..|..|.||. ||.|...|... .|. 
vPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 873-1136 2.3e-100 330.4 In-house 15-279 (288) alignment 
Range on Protein: 873-1136
Range on HMM: 15-279/288.0
MLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQN
.  ..   |||||....|.. ..|..|. |..|  |||| |||.||. ||||.  ..|.|.|||||.|| |.. ...||||||||..| .|||.. .|..
ksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

SHVIVMLTQLVERGRTKCHRYWPGAQ-PEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGP
.. |||||.|||.|.|||..||| |. |. ||...| .... |. |...||. . |.|  ..||.||. .|||||||. . | |...| |.   ..  ||
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgp

VIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
.||||||||||||||||| .|..... .| .|..|  ...|..|. ..||. ||.||......  
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0040438 (Phosphotyrosine protein) phosphatases II 865-1138 1.9e-99 328.2 In-house 4-278 (317) alignment 
Range on Protein: 865-1138
Range on HMM: 4-278/317.0
DFPSYVEDMLNDAGFKFSEEYEKVSAVGLDhSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDF
|.. ...|.|.    ...||.|..  . || . . ..||||. ||||..|| |||||||| ...  ..||||||.|..|.. .|..||||||||.|..||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVH
||| |||...||||||.|.|.|| ||..|||  .. .||.. | .|||.|......|.....  ... |||.||... .|||||||.   . |||...|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

EVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
|. ..  |||.|||||||||||||||. ..|.... .  ||..    |.|..|....||. ||.|...|. . .| 
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0046845 (Phosphotyrosine protein) phosphatases II 881-1138 4.9e-99 326.5 In-house 2-276 (284) alignment 
Range on Protein: 881-1138
Range on HMM: 2-276/284.0
FSEEYEKVSAVGLDH--SKDASLLPENRAKNRYTNILAYDHSRVKLESIDDE-PGSDYINANYIPGY-----RMRRAYIATQGPLPSTFDDFWRMTWEQN
. ||.|..  .  ..  | ...|||||. ||||..||.|||||||| |.|.. ..||||||.|..||     . ....||||||||.|..||||| ||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SHVIVMLTQLVERGRTKCHRYWPGAQ-PEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVAS--
..||||||.|||.||.||..|||  . . .||.. | .|||..|.|..||....|.   .. |||.||... ||||||||... . |.|.|.|.|. .  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

SAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHD---WVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
.  ||..|||||||||||||||| .||.... ..    ||.... . .|..|..|.||. ||.|...|.....|.
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPRG_pd Subfamily PTPRG 862-1139 2.2e-98 324.9 In-house 2-290 (563) alignment 
Range on Protein: 862-1139
Range on HMM: 2-290/563.0
YLRDFPSYVEDMLNDAGFKFSEEYEKVS--AVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGS-DYINANYIPGYRMRRAYIATQGPLP
 ...| ..| ..  |.  .||||.|..    .  |   ..|  |||. ||||.||.|||.|||||... .. .. |||||||| ||.  .|.|||||||.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

STFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK-----EK---RSRTITHYQFVSWPDHGVPDE
.|||||||| ||||...|||.|.|||||| ||..|||  ..| ||...| . .|  ..   ||...| .     .|     .....|.. .|||||||. 
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

AGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
. | | ||.       .. ||..||||||||||||.|.| |||. |.... |..||..  .| .||...||| ||.|.|.|...| .| 
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
0043336 (Phosphotyrosine protein) phosphatases II 864-1134 3e-97 320.7 In-house 5-275 (278) alignment 
Range on Protein: 864-1134
Range on HMM: 5-275/278.0
RDFPSYVEDMLNDAGFKFSEEYEKVSAVGLdHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDD
 |.. .....| .   ....|.|..  . |  ... .|||||. ||||..||.||||||||.... ...||||||.|..||.. |..||||||||.|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPgAQPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREV
|||| ||.....|||||.|||.||.||..|||  ....||.. | .|.|....|..||....|  ... |||.|||....|||||||.   . |||...|
FwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

HEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.|. ..  |||.|||||||||||||||| .||......  |||.   .|.|..| ...||. ||.|...|. .
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 867-1139 6.8e-97 319.4 In-house 11-286 (319) alignment 
Range on Protein: 867-1139
Range on HMM: 11-286/319.0
PSYVEDMLNDAGFKFSEEYEKVSAVGLDhSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWR
 .... . . .  .. .|.....  . | . | .  .||. ||||.||||||..||.| ..|. .|||||||..| ||. |...||||.||  |..||||
kerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK---RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE
| ||..|...||||.|||... |...||| ...|.||.. |....| |..|.|.||.|. | .    .|...|.|. .||||.||..|   ||.......
mvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

VASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
  .    ||..||||||||||||||.|   |...|    .|.|  .|..|  || |.|.. || ||..|...| .. 
srektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
0047943 (Phosphotyrosine protein) phosphatases II 880-1134 1e-96 318.8 In-house 13-270 (273) alignment 
Range on Protein: 880-1134
Range on HMM: 13-270/273.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLesidDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
.. ||.|..  .  .... ..|||||. ||||..||.||||||||    ...|||||||.|..||.. |..||||||||.|..||||| ||||..|||||
llleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

TQLVERGRTKCHRYWPGAQ---PEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGPV
|.|||.|| ||..|||  .   ...||.. | .|||..|.|..||....|.   . |||.||... .|||||||.   . |.|...|... ..    |||
telvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpv

IVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.|||||||||||||||| .||.... .  ||.. .   .|..| .|.||. ||.|...|...
vVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 880-1137 1.7e-96 318.3 In-house 14-278 (297) alignment 
Range on Protein: 880-1137
Range on HMM: 14-278/297.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLesidDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
....|.|..  . |. |....|||||. ||||..||.|||.||||    |..|||||||.|..||.  |..||||||||.|..||||| ||||..|||||
lllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETE--KSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGP
|.|||.|| ||..|||    .. .||.. | .||...  ..|...|....|.  .. |||.||... .|||||||. . . |||...|..| .     ||
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

VIVHCSAGVGRTGTFIALGTLLQHIK---DHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|.|||||||||.|||||. ..|| ..    .  ||.. .  ..|..|....||. ||.|.. |. . .|
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0039614 (Phosphotyrosine protein) phosphatases II 857-1136 4.3e-95 313.8 In-house 10-289 (297) alignment 
Range on Protein: 857-1136
Range on HMM: 10-289/297.0
NSRKVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDhsKDASLLPENRAKNRYTNILAYDHSRVKLESIDDE-PGSDYINANYIPGYRM-RRAYIATQ
.|  ..|. .. ..  .  .   .. .|.|..  .  |  .  .|||||. ||||..||.|||||||| ..|.  ..||||||.|..||..  |..||||
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRtKCHRYWPGAQPeVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPA
||||.|..||||| |||...||||||.|||.|| ||..|||  .  .||.. | .|.........||....|... |||.||.|...|||||||. .   
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslell

LDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
|.|...|.|. ..    |||.|||||||||||||||. ..|.... .  ||..   .|.|..|....||. ||.|...|... .
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 878-1138 4.8e-95 312.9 In-house 14-278 (281) alignment 
Range on Protein: 878-1138
Range on HMM: 14-278/281.0
GFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIV
   | |||||..|.|.|..  ||  .||. ||||.|| |||..|||..  ...  .||||||..|||.  ..|||||||.|.....||.| |||. ..||
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTQLVERGRTKCHRYWPGAQ-PEVYGEINVDMLSETEKSDWIVRKFKI-TKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF-GPVIV
|.|. .| |. |||||||  .    ||.. | ...|.||. .| ||||. ...  .|.... ....|||||||...   |.| .||... ..    |...
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGVGRTGTFIALGTLLQHI-KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
|||||||||||.||| .|.... ...  .|.  .  |.|..|| |.||  || |..||..|| . 
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
DSPc_SM00195 880-1136 4.3e-94 310.1 In-house 1-262 (263) alignment 
Range on Protein: 880-1136
Range on HMM: 1-262/263.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
|..||.||. .   ..... .  ..|..||||.||| |||.||||.......|||||||||| |.. ...|||||||||||..||||| ||.....||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKS-DWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
|. .|.|..||.||||    ..|..|.|.| . ....|. ..|.|....|||.   .|..|.||. .||||||||.. . |...|.|..  |.  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
||||||||||||... ..|....... ||.| . .|.|..| .|.||. || ||..|.....
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 880-1136 4.3e-94 310.1 In-house 1-262 (263) alignment 
Range on Protein: 880-1136
Range on HMM: 1-262/263.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
|..||.||. .   ..... .  ..|..||||.||| |||.||||.......|||||||||| |.. ...|||||||||||..||||| ||.....||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKS-DWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
|. .|.|..||.||||    ..|..|.|.| . ....|. ..|.|....|||.   .|..|.||. .||||||||.. . |...|.|..  |.  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
||||||||||||... ..|....... ||.| . .|.|..| .|.||. || ||..|.....
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045450 (Phosphotyrosine protein) phosphatases II 856-1135 1e-93 309.7 In-house 4-303 (307) alignment 
Range on Protein: 856-1135
Range on HMM: 4-303/307.0
PNSRKVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGL--DHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDE-PGSDYINANYI--------PGY
| |... .... ..|  .| |   .. .|.||.  |     .. ...|||||. ||||..||.|||.|||| |.|.. ..||||||.|.        .||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

RMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA-QPEVYGEINVDMLSETEKSDWIVRKFKIT---KEKRSRTITHYQFV
.  |..||||||||.|..||||| |||...||||||.|||.|| ||..|||   .. .||.. | .|||.......||....|   ... |||.||... 
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

SWPDHGVPDEAGPALDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW---VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
.|||||||.   ..|||..||... ..    |||.|||||||||||||||. ..|...... .   |||.   ...|..| ...|.. ||.|...|. . 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 868-1138 2.1e-92 304.6 In-house 16-292 (298) alignment 
Range on Protein: 868-1138
Range on HMM: 16-292/298.0
SYVEDMLNDAGFKFSEEYEKVSAVGL---DHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDF
 ... . .    ....|......|     ...|...  |||. ||||..|.|.|.||| ||..|..  |||||| .. .|. | |.||||.||..|. ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVH
||| .|... .|||||.|.| ..||.|.|||  . | ||||.|..||. |..| ||||.|..|.|  ..|.. . .|.||||.||| .|   ||..|.|.
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

EvASSAFG--PVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
    .  |  ||||.|||||||.|||||. ..|...|    ||.|     .|..| ...||| |||||..|. .| .|
a.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_PTPRK_pd Subfamily PTPRK 870-1138 4.7e-88 290.0 In-house 13-279 (314) alignment 
Range on Protein: 870-1138
Range on HMM: 13-279/314.0
VEDMLNDAGFKFSEEYEKVSAvGldhsKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTW
.  .    |. | |||| .   |     ||.   |||.|||...|||||.|||.| .||..| ||||||..| .|.  .|.|.|||||..|  ||||. .
iallkraegygfkeeyeslfe.g....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvy

EQNSHVIVMLTQLVERGRTKCHRYWPGAQPEvYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVA
..|.  |||||.||| || || .|||      ||.|.| ... . ... .|| |...|     .  |.. ..||..||||.|| .|   |..||.|..  
dencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
    |...|||||| ||||||||. ..|. |. .. ||.|  . ..|...  |..|| ||.||. ....||  
eeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc
0040439 (Phosphotyrosine protein) phosphatases II 898-1135 9.1e-88 289.3 In-house 4-245 (249) alignment 
Range on Protein: 898-1135
Range on HMM: 4-245/249.0
DASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA
. .|||||. ||||..||.||||||||..... ..||||||.||.||.. |..||||||||.|..||||| ||....||||||.|||.|| ||..|||  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

QPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLL
.. .||.. | .||...|.|..||....|  ... |||..|.|...|||||||.   ..|||...|... ..    |||.|||||||||||||||. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

QHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
.... .  |||.   ...|..|....|.. ||.|...|. . 
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 899-1134 2.3e-87 287.7 In-house 3-241 (245) alignment 
Range on Protein: 899-1134
Range on HMM: 3-241/245.0
ASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQ
 .|||||. ||||..||.|||.|||| ... ...||||||.|..|||. . .||||||||.|..||||| ||.....|||||...|.|| ||..|||  .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

PEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVAS-SAFGPVIVHCSAGVGRTGTFIALGTLLQH
. .||.. | .|||. ..|..||....|  ... ||...||....||||||||     |||...|... . .. |||.|||||||||||||||. ..|..
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.. .  |.|.    |.|..| ...||. ||.|...|. .
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 875-1134 3.2e-87 287.7 In-house 3-270 (278) alignment 
Range on Protein: 875-1134
Range on HMM: 3-270/278.0
NDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKlesiddepgsDYINANYIPGYrmRRAYIATQGPLPSTFDDFWRMTWEQNSH
..|  ... |.| . . |   .   .|...|..||||..||.|||||||          |||||.||.||  ....||||||||||..||||| ||....
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

VIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT------KEKRSRTITHYQFVSWPDHGVPDEA--GPALDFVREVHEVAS
||||||.|||.|| ||..|||  ....||.. | .|||.. .|...|....|      ..  ||..||.....|||||||..    . |.......|. .
vivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

-------------SAFGPVIVHCSAGVGRTGTFIALGTLLQHIkdHDWVDLFGLASEMRQHRNH-MIQTEPQYVFIHKAMVD
             .  |||.||||||||||||..|. ..|...  .. |||.   .|.|..|.. ..|.. ||.|.......
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPRA_pd Subfamily PTPRA 875-1134 4.8e-87 286.9 In-house 28-293 (330) alignment 
Range on Protein: 875-1134
Range on HMM: 28-293/330.0
NDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSH
 |   .| ||.. . |  .. . ...   ||. |||. ||| ||.||| |  .. .. |||||| .| ||. .  .||.|||.  | .||||| |||.|.
addnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksa

VIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT------KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSA
 |||||.| || ..||..|||      ||.|.| .  ||.  |. |||| ..      .||.|| .. . | |||| ||| |.   |.....|...    
tivmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

FGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
 ||..||||||||||||||.| ..|. .|    ||.|.  ...|. | .|.||. ||.||.|.. .
agpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_PTPN6_pd Subfamily PTPN6 880-1134 3e-86 284.2 In-house 27-295 (306) alignment 
Range on Protein: 880-1134
Range on HMM: 27-295/306.0
KFSEEYEKVSAV--GLDHSKDASLLPENRAKNRYTNILAYDHSRVKLEsIDDEPGSDYINANYIPGY--RMRRAYIATQGPLPSTFDDFWRMTWEQNSHV
 |.||.|...       .|.. .  |||. |||| ||| .||.||.|.  .. ||||||||||| .     ...|||||| |..|  ||||| |..||.|
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTQLVERGRTKCHRYWPGA-QPEVYGEINVDMLSETEKSDWIVRKFKIT---KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF--
|||.|. ||||. || |||| . . | ||.|.| ..||....|.|.|.....   |.|..|.. .|.| |||||||| . |  |||...|.. ...    
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

--GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW---VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
  ||..||||||.||||||| . .||. |. . .   .|.  |   .|..|. ..||| || |..||.  
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
Y_phosphatase Protein-tyrosine phosphatase 905-1133 7.8e-86 282.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 905-1133
Range on HMM: 1-234/235.0
NRAKNRYTNILAYDHSRVKLesiDDEPG-SDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWP--GAQPEV
|. ||||..||.||..||||   ....| ||||||||. ||.  ...|||||||.||..||||| |.....||||||.|.|.||.||..|||    ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEINVDML-SET-EKSDWIVRKFKITKEKRS---RTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHI
||.|.| .  .|. .......||....|.|..   |....... .|||||||... . ||..|.|..  ..  |||.|||||||||||||.|| .||...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.... ||.. . .|.|..|..|.|.. ||.|..||..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 905-1133 7.8e-86 282.7 In-house 1-234 (235) alignment 
Range on Protein: 905-1133
Range on HMM: 1-234/235.0
NRAKNRYTNILAYDHSRVKLesiDDEPG-SDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWP--GAQPEV
|. ||||..||.||..||||   ....| ||||||||. ||.  ...|||||||.||..||||| |.....||||||.|.|.||.||..|||    ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEINVDML-SET-EKSDWIVRKFKITKEKRS---RTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHI
||.|.| .  .|. .......||....|.|..   |....... .|||||||... . ||..|.|..  ..  |||.|||||||||||||.|| .||...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.... ||.. . .|.|..|..|.|.. ||.|..||..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Ptp69D_pd Subfamily Ptp69D 861-1137 1e-85 282.6 In-house 4-287 (307) alignment 
Range on Protein: 861-1137
Range on HMM: 4-287/307.0
VYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPST
. . | .. ..   .|. | . .||||. |   |.|  .|   ||  |||| .| |.|. ||||. |  .  ||||||..| ||. .. .|| |.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

FDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK-------RSRTITHYQFVSWPDHGVPDEAGP
 .||||| .||....||||..| |  | ||..|||  .   ||.|.|.. || ..||.| |.....| |        || .. |.. .|.|  ||. |  
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

ALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
 |.....|.|. .   .|..|||||||||.|.|.||  |||..|  | ||.|    ..|..|| ..|   ||||...|..|  .
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 903-1138 1.4e-85 281.5 In-house 7-244 (250) alignment 
Range on Protein: 903-1138
Range on HMM: 7-244/250.0
PENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTkCHRYWPGAQPEVY
|.|. ||||..|.|.|.||| ||. . .  |||||| .. ||. |.|.|||||||..|. ||||| .|..| .|||||.|.| ..| .|.|||  ..| |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

GEINVDMLSETEKSDWIVRKFKITKEKRSRT--ITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDH
|.. |..||. |..|...||.|..|.|..    . ...||.||| |||..|  .|.....|.        .||||.|||||||.|.|||. ..|...|  
GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkke

DWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
  ||.| .   .|..| |..... ||||.....  | .|
kvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN9_pd Subfamily PTPN9 881-1136 2e-85 281.4 In-house 18-290 (297) alignment 
Range on Protein: 881-1136
Range on HMM: 18-290/297.0
FSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLT
 |.||... .       .|| |. |  |||||..| ||..||.|...|... |||||||.. ||. ..|.|||||||. |..||||| |||.  |||| |
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt

QLVERGRTKCHRYWPG--AQPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSA---F----
..||||| || .|||    . . .|...|  ..  |..|. ||...|.  |...||..||.||.||||.|||..|   ||....| |  ..|   .    
rvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdew

------GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
       |..||||||.|||||||.|   |..... . ||..   . .|. | ..|||. ||.| ..|...  
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 862-1138 2e-83 275.0 In-house 5-285 (305) alignment 
Range on Protein: 862-1138
Range on HMM: 5-285/305.0
YLRDFPSYVEDMLNDAGFKFSEEYEKVSAVglDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTF
 | |. .|....  .   .. ..|...     ..| |     .|.||||...|  .|..|..|   .... ||||||.|. ||. . .||..||||..| 
alddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

DDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE--VYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALD
.||||. .|   ..|||||.||| |. ||..|||... |   .||..| . ||.. ||.| ||.||..   .| |||...||. .|||||||..|.  |.
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FVREVHEVASSAFG-PVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
....|..  ..  | |..|||||||||||.|||.   |...|  . ||.|..  ..|..|  |.||  ||||.| |. .  ..
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_PTPN12_pd Subfamily PTPN12 897-1141 2.4e-83 274.4 In-house 32-282 (290) alignment 
Range on Protein: 897-1141
Range on HMM: 32-282/290.0
KDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG
..|.  .||..|||| .|| ||.|||.|. |..|.||||||||.| |   . .|||.||||| | |||||| ||.| ...||. ..|| |..||.|||| 
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

A-QPE-VYGEINVDMLSETEKS-DWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLL
  . |  .||..|.. .|   . |...| .|....| ||... ... .|||||||  | . |.....|.|. .|   |..|||||||||||| ||.    
egeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvr

QHIK---DHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSMS
. .|     . .|.| |  |.|..|. ..||. ||....||... ......
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 864-1158 8.8e-82 270.0 In-house 14-308 (319) alignment 
Range on Protein: 864-1158
Range on HMM: 14-308/319.0
RDFPSYVEDM-----LNDAGFKFSEEYEKVSAVGLDHS-KDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPL
.||| |  ..     ..|   |.  |. ... .| . . .. . |..|. |||..||||.|...|||| .. | .|||||| .. ||. .  |||.||||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

PSTFDDFWRMTWEQNSHVIVMLTqlvergRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPA
. | .||||| ||.|.  ||.||      . || .|||    . ... .|.. | .| ....||......   ||  | || . |  |||.|||| . . 
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdl

LDFVREVHEVASSAF--GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACkssmsKFGGGIKVLPS
. .|. |. . |      ...|||||||||||..|.| .||. .|. . ||.. .  ..|| ||...|   || ||. |...        ||    ..| 
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh.....lfghsdvampd

FPIYSN
|| | .
fpayle
0037934 (Phosphotyrosine protein) phosphatases II 899-1133 3.5e-81 267.6 In-house 4-239 (243) alignment 
Range on Protein: 899-1133
Range on HMM: 4-239/243.0
ASLLPENRAKNRYTNILAYDHSRVKLesiddePGSDYINANYIPGYRmrRaYIATQGPLPSTFDD----FWRMTWEQNSHVIVMLTQLVERGRTKCHRYW
 .|||||. ||||..||.||||||||      .||||||||.|....  | .||||||||.|..|    |||| ||....||||||.|||.|| ||..||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PgaQPEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEV--------ASSAFGPVIVHCSAGVGRT
|  ....||.. | .|||....|..||.....    .. .|...||....||||||||.  . |||..||.|.        | .  |||.||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFIALGTLLQHIkdhDwVDLFGLASEMRQHRNH-MIQTEPQYVFIHKAMV
||.||. ..|...   . |||.    ..|..|.. ..||. ||.|...|. 
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 890-1137 1e-79 262.5 In-house 13-269 (274) alignment 
Range on Protein: 890-1137
Range on HMM: 13-269/274.0
AVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESI-DDEPGSDYINANYIPGYRM-RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGR
 . |.....   .. .  ||||..||  ..||| |||   ... |.||||||| ||.   .||.|||||||.| .||||| ......||||||.| |. .
elPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane

TKCHRYWPGAQP----EVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS---AFGPVIVHCSAGV
.||..|.| |.     | ||.... . . .|. |. |||. . . .|.|...|| . .|||| .||.| . ||.|.||.| ...     .||.||||||.
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGi

GRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|||| |||    .......  ||.... ...|..|  |.||. || .||.|..   |
GrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 885-1158 1.2e-79 262.8 In-house 4-272 (284) alignment 
Range on Protein: 885-1158
Range on HMM: 4-272/284.0
YEKVSAVGLDHS-KDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTqlv
. ... .| . . .  . |..|. |||...|||.|...|||| .. | .|||||| .| ||. .  ||||||||. | .||||| ||.|.  ||.||   
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...

ergRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF--GPVIVHCSA
   . || .|||    . ... .|.. | .| ....||......   ||  |.|. . |  |||.|||| . . . .|. |. . |      ...|||||
...kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACkssmsKFGGGIKVLPSFPIYSN
||||||..|.| .||. .|. . ||.. .  ..|| ||...|   || ||. |...        ||    .|| || | .
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh.....lfghsdvalpdfpayle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 864-1134 2.4e-79 261.8 In-house 5-274 (515) alignment 
Range on Protein: 864-1134
Range on HMM: 5-274/515.0
RDFPSYVEDmlNDAGFKFSEEYEKVSAVGLDHSKdASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDD
 .||..|.   |     ||||.  .    .      .    |  |||| ||| || .||||| |.|.| |||.|| |||..   .||||.|||.... ||
aqfPafvnk..nrhttlfseefhdlpgpniypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvdd

FWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG--AQPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREV
|||. ...|   |.|.|.| |  . || .|||   ..   .|.|.|...|    .. | ||....|.. |||.| ..|  |||.||| ..   | ...||
fWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikev

HEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
    .    |.|.|||||||||| .|..   . |.|. . ||.| .   .||.| ...||. || ||. |. .
kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 863-1134 8.4e-79 259.6 In-house 5-275 (315) alignment 
Range on Protein: 863-1134
Range on HMM: 5-275/315.0
LRDFPSYVEDmlNDAGFKFSEEYEKVSAVGLDHSKdASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFD
. .||..|.   |     ||||.  .      . . ..  ..|  |||| ||| .|..||||| |||.| |||||| ||...   .||||.||||... |
vaqfpafvnk..nrhtalfseefhdlpdPdiyrqr.varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvd

DFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG--AQPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVRE
||||| ....   |||.|.. |  . || .|||   |.   .|.|.|..||    .| ..||. . | . |||.| .||  |||.||. ...  | ...|
dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklike

VHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
|     .   ...||||||||||| .|..   ...||. . ||.| .  ..|..| ...||| .| ||. |. .
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_PTPN3_pd Subfamily PTPN3 894-1137 1.1e-78 259.0 In-house 30-276 (280) alignment 
Range on Protein: 894-1137
Range on HMM: 30-276/280.0
DHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANY----IPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTK
. . .|. .||| .|||| .||.||. ||||.. .     |||||||    ||.  .   ||||||||..|  |||.|.|||.|..|||||.||||||.|
glaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CHRYWPGAQPEV-YGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTF
||.|||  . |. |||..| . .| |.. ...|.. .....  ..|.|.. |...||||||||..   |.||..|... |..  ||.||||||.|||| .
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

IALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|.| | |. |  .. |    . ..||. |  ..||. || |. .|.. . .
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 875-1135 1.2e-77 255.9 In-house 20-278 (315) alignment 
Range on Protein: 875-1135
Range on HMM: 20-278/315.0
NDAGFKFSEEYEKVSAvGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSH
  .   | ..|| .   |  |  | .   ||. |||| ||.|||.|||.|  .. .|.|||.|||.|.||  .| |||.|||.... .||||. .|..  
astkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedig

VIVMLTQLVERGRTKCHRYWPGAqPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
 |||||.|||. . |. .|||     .||.| | . ||  .... || . .. ... |..  ... |||| |||  . | ....| |.    .. |...|
kivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivv

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
|||||||||||||.| ..|....  . .|.. .   .|| | .|.|.  || ||..|....
hcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 903-1138 1.4e-73 242.6 In-house 46-286 (297) alignment 
Range on Protein: 903-1138
Range on HMM: 46-286/297.0
PENR---AKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMrrAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRtKCHRYWPGAQP
 |..    |.||.||| || |||||....|.| |||.|| ...|..    .|.|| | ..| .|||.| ....  .||||... || . || |||.    
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

EVYGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPD--EAGPALDFVREVHEVASSAF-GPVIVHCSAGVGRTGTFIALGTLLQ
  .|.. | .|| .|..  | |....||.|    | .  ||||.|||. |.   .|   |... ||... |.   ||..|||.||||||| ....   . 
ttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvva

HIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
..|... ||.||| . .||.| ...||. || |...|...|  |
eakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPN13_pd Subfamily PTPN13 882-1137 2.2e-72 238.6 In-house 14-270 (273) alignment 
Range on Protein: 882-1137
Range on HMM: 14-270/273.0
SEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLEsidDEPGsdYINANYI--PGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
.||....  .    . . .   ||..|||| |.| ||..||||.   || |  ||||..|  |    .  |||.||||| | .|||.| |||...||.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQLVERGRTKCHRYWPGAQP---EVYGEINVDMLSETEKSDWIVRKFKITKE--KRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASsAFGPVIV
|. .|.|. |||||||  .     |.. ..|..|  ...... ||......   ..|| ..| .||.||||||| .| . | ||.|| ....   ||..|
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|||||.||.||.|.. ..|. |.    .|.  .  ..|. |. ..||. ||.|..||.... |
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 904-1138 2.3e-71 234.9 In-house 19-266 (270) alignment 
Range on Protein: 904-1138
Range on HMM: 19-266/270.0
ENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRM-RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE--
 ... |||..||   ..||.||...... . ||||||..|.   ...|||..||||.|  .|||| ||.... |||.|.|.|.||.|| ||||  . |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--VYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAG------PALDFVREVHEVASSA--FGPVIVHCSAGVGRTGTFIALG
   .|.|.|  |||. .. .|... .....  .| ..|.....||||||| |..        |  .|.|... ..    .|..||||||||||||.||| 
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

TLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
. .. .. .  ||.  . .|.|..|  ..|.  || |..||.|  .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 880-1139 6.2e-69 227.6 In-house 24-291 (325) alignment 
Range on Protein: 880-1139
Range on HMM: 24-291/325.0
KFSEEYEKVSAVGlDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
 |. |.. . ...   .| .. .|||.||||. |..|.|.||| ||. .|.| ||||||.|.  .. .  ..|.| ||..| .|.||.  . .. |.|.|
gfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl

TQLvERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKSDWIVRKFKITKEKRS--RTITHYQFVSWPDHGVPDEA---GPALDFVREVHEVAS---SAF
 .| . |  .|  |||    .   .| ..| . .  | ||.. |.... . |.   |..  .|. ||.| ||.       . |. | .|.|       | 
nel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
.|..|||||||||||.||.| ..|... ..  ||.||    .|..|  |..|  ||..|..|.|.|  |.
tpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 864-1138 5.5e-68 223.9 In-house 5-285 (290) alignment 
Range on Protein: 864-1138
Range on HMM: 5-285/290.0
RDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPG--SDYINANYIPGYRMRRAYIATQGPLPSTF
 .|  .|.        .| ...... .   .|.    | ..|. .||..||. ||  |. |  | ...    .|||| || ||. ...|||||||...| 
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

DDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEKR---SRTITHYQFVSWPDHG-VPDEAGPALDF
 |||.. |.... .|||||. .| |..||. ||| .. . |||... .|.|.. .. | ||.......    ....|.||. .|...| |.....  | .
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

VREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
 . ..    .  ....||||..|||...|.|. | ... |    .|.| .  ..|. .  ..||. || .|.. .. . .|
eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN1_pd Subfamily PTPN1 883-1138 1.3e-67 222.5 In-house 10-273 (290) alignment 
Range on Protein: 883-1138
Range on HMM: 10-273/290.0
EEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQL
| |....    |..  .. |||||..||| ..  |||||.|||. |     |||||. .   ...| || ||||||.| | ||.| |||.|. .||| ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

VERGRTKCHRYWPGAQP--EVYGE---INVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVA--SSAFGPVI
||....||..|||  .   |.  |   ..|...|| .|| ..||......   ...|.|.|. ...||| |||.  .  |.|. .| |    ||  ||..
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpav

VHCSAGVGRTGTFIALGTLLQHIKDHDW---VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
.|||||.||.|||. . |.| .|...|    ||.     |.|..|  .|||  |  | . |...  | 
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 903-1133 3.1e-67 221.3 In-house 1-236 (237) alignment 
Range on Protein: 903-1133
Range on HMM: 1-236/237.0
PENRAKNRYTNILAYDHSRVKLESIDDEpgSDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG-AQPE
.||..|||| || ||||||| |.    .  ||||||.|. |.    . |||.|||| |. ||||.| |...  |||||| |.|. . |||.|||   ||.
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

VYGEINVDMLSETEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLLQH
 || . | .  . | ||. || . ..|.   |  | |  ||| ||||.|||...   | | ... . .      || |.|||||||||| |. . ..|..
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
 |..  ||..     . . | ..|||. ||||||....
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 869-1139 2.6e-66 218.5 In-house 10-281 (287) alignment 
Range on Protein: 869-1139
Range on HMM: 10-281/287.0
YVEDMLNDAGFKFSEEYEKVSAVGL-DHSKDASLLPENRAKNRYTNILAYDHSRVKLEsiddEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRM
.|..  .     |.. .  .  |.  ...   .. ..|. |||.|.|| .|  || |.    .   ||||| .| ||. ..|.|....|. .|  .||..
fvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

TWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK---RSRTITHYQFVSWPDHG-VPDEAGPALDFVREVHE
 ...| ..||||.|. |  . .|..|||  .  |.|| |. .|.|. ....|.||.......     .... ||. .|...| |.. .   | . . ...
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

VASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
   .. ....||||..|||...|.|  | ... |    .|.| .  ..|. . ...||  || || ....   .| 
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 865-1135 3.4e-65 215.2 In-house 6-278 (439) alignment 
Range on Protein: 865-1135
Range on HMM: 6-278/439.0
DFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPEN--RAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFD
.|  .||.. ..    |.|..||....  |.. .|||. ..  ..|||| .. |.||.|| |. |   | | ||||||| ||   . |||||||   | |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMTWEQNSHVIVMLTQLVERGRtkchrYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKE----KRSRTITHYQFVSWPDHGVPDEAGPALDFV
||||. .|...  |||||.|||  .     |||  .  .||.| | .  . |  ....| ||. .|    .. ||. ......|||. || .|   |||.
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

REVHEVA-SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
| .     .  .|||.|||||||||||| |||   |...|  . ||. |. . .|..|..|.|.  |||||..|... 
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 905-1135 5.3e-63 207.3 In-house 7-239 (239) alignment 
Range on Protein: 905-1135
Range on HMM: 7-239/239.0
NRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQpEVYG
|.|||||.||..|||||| || . ..| ||||||.|.  |    .||||||| .  .  ||||| |..   |||||| |.|  . |||.||| .    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

EINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW
.. | .      .|.|.| | ...  .   | . .|.|  |||.|||. |   | . |.. . .     | ..||||||||||.|. . ..|.. | .  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
||.|     .|. | ||.||  |||||| |...|
vdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPN23_pd Subfamily PTPN23 895-1144 7.4e-63 207.0 In-house 31-288 (288) alignment 
Range on Protein: 895-1144
Range on HMM: 31-288/288.0
HSKDASL--LPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCH
.... |.     .  |||...|| |||.||||..  |    ||||| .. .   .   .||||.||.||  |||.| .|| | |||||..  |.|..|..
earkrsiaiaklyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

RYWPGA--QPEVYGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE----VASSAFGPVIVHCSAGVGRT
|||| .  .....|...| . |..| . .. |..|.. ..  . ....| |. |||..|||.  .  |.|. ||..    |   .  |..||||||||||
rYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRt

GTFIALGTLLQHIKDHD-WVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSMSKFG
|.|  . . .. .. ..  .|.  . | .|. | .|.|.. |. |  .|.. | .  . | |
gvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkrG
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 905-1133 1.1e-62 206.3 In-house 8-238 (239) alignment 
Range on Protein: 905-1133
Range on HMM: 8-238/239.0
NRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQpEVYG
|.|||||.||..|||||| || . ..| ||||||.|.  |    .||||||| .  .  ||||| |..   |||||| |.|  . |||.||| .    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

EINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW
.. | .      .|.|.| | ...  .   | . .|.|  |||.|||. |   | . |.. . .     | ..||||||||||.|. . ..|.. | .  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
||.|     .|. | ||.||  |||||| |..
vdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN14_pd Subfamily PTPN14 881-1139 2.2e-61 202.5 In-house 25-299 (300) alignment 
Range on Protein: 881-1139
Range on HMM: 25-299/300.0
FSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEpGSDYINANYIPG--YRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVM
   |||...   .|   ... ||||  |||. ..| |...||.| .  ..  ..||||  |       .| ||..||||. |  |||.| |||. ..|||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LTQLVERGRTKCHRYWPGA----QPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVAS---SAF
||.  | |..|...|.|      .   .|. .|     .. .  | ...|.     |. ||. | |.. |||||||..  . |....||. |     |  
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

------GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
       ||.|||||||||||  |    |.. ..  . .|.    . .|. | ...||  || |..|...   |.|
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_PTPRN_pd Subfamily PTPRN 868-1135 2.8e-61 201.8 In-house 19-291 (297) alignment 
Range on Protein: 868-1135
Range on HMM: 19-291/297.0
SYVEDMLNDAGfKFSEEYEKVSAVGLDH-SKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRR-AYIATQGPLPSTFDDFW
||.|| |..   ....|.| . |   .  .|...  ..|  |||....|.||||||||..  ..  ||||||  |     |. |||||||||.||  |||
syledhlknkd.rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfw

RMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEK-SDWIVRKFKI--TKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVH
.| ||| . |||.||.| | | ..|.||||    |||.  .|...||     |..|| | .   . ...||.| . |.|||..||| .| . |.| | | 
qmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn

EVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHI-KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
        |..||||.|.||||..|..  .|... |    .|.      .|. |.....|. |. |. .|... 
ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 864-1134 7.3e-61 200.7 In-house 7-234 (392) alignment 
Range on Protein: 864-1134
Range on HMM: 7-234/392.0
RDFPSYVEDMLNDAgfKFSEEYEKVSAVGLDHSKDAsLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDD
 .||..||.    |   |.||.  .    . . . |   . |  |||| ||| || .||||| ||| | |||.|| |||..   .||||.||| ....||
aqfpafveknrhsa..lffeefhdlpgpdiypqtva.qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasldd

FWRMTWEQNSHVIVMLTQLVERGrtkchrywpgaqpevygeinvdmlseteksdwivrkfkitKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE
|||| ...|   |.|.|.| |                                          | .  ||.. ..|. |||..||  .   | |..||. 
fwrmvfqenvttiamvtklkegd........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

VASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
   .   |.|.||||||||||  |.. ... | |    ||.| . ...|..| .|.||. || ||. |...
dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 905-1137 1.9e-59 195.8 In-house 38-278 (287) alignment 
Range on Protein: 905-1137
Range on HMM: 38-278/287.0
NRAKNRYTNILAYDHSRVKLeSIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA-QPEVYG
.  ||||...| .|..|| | | . | |||||||||...|.   |.||.|||...|  ||||. .|..| .....|. || .| ||..|||   .|   |
avkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EINVDMLSETEKS-DWIVRKFKITK-EKRS-RTITHYQFVSWPDHGVPDEAGPALDFVREV---HEVA--SSAFGPVIVHCSAGVGRTGTFIALGTLLQH
   | .|. . |. .. || ... . | |  | .  ....||||....  |   . || .|    |.|  .|  ||..||...|.||.|...|. .|.. 
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
 .|   ||       .|..|. ..|.  |. .. .|.|   |
ledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0051429 (Phosphotyrosine protein) phosphatases II 931-1138 1.9e-57 190.2 In-house 2-227 (272) alignment 
Range on Protein: 931-1138
Range on HMM: 2-227/272.0
PGSDYINANYIPGYRM---RRAYIATQGPLPSTFDDFWRMtWEQNSHVIVMLTQLVERGRTKCHRYWP------------GAQPEVYGEINVDMLSETEK
| |.||||....||     ........|||| | .||||. .|.. ..||.|....|||| ||.||||            .|..  || . | .|||. .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

SDWIVRKFKIT---KEKRSRTITHYQFVSWPDHGVPDEAgpALDFVREVHEvassaFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVD--------L
.|.|.|.. .|   . . .|...|... .|||||||.||   |........      |||.||||||..||||..||  ||. . ... ||        |
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
..  .|.|..| ...||| ||.|...|.... .|
eeaveelraqrpgavqteeqylflyeallellrs
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 881-1134 5.9e-57 187.7 In-house 11-264 (283) alignment 
Range on Protein: 881-1134
Range on HMM: 11-264/283.0
FSEEYEKVSAVGLDHSKDASllPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIP---GYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIV
| | ....|   ||   ...   ||. |||. .|...|  ||.|.|       ||||| .||    |.  . ||..|.||  |  |||.| ....   ||
frevlkrlsvpdldadiasa..denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
|||.| |  | || .|||    | |||  | .  || .  .|.... . ..   | .  ..|||.. | . |        . | . .     |  ||..|
mltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
|||.|.|||..|||. . ..... .  ||.|     ||..|  ..||  || ..|.....
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG7180_pd Subfamily CG7180 881-1135 3.7e-56 184.9 In-house 19-289 (296) alignment 
Range on Protein: 881-1135
Range on HMM: 19-289/296.0
FSEEYEKVSAVGLDHSKDaSLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLT
.  |..... .  .. .   |  ||| |||. ... ||. || ||..| |  |||||| |. ..   ..|| |..|  .| |.|||. ...... .|.||
yklelkltprleigdCag.glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

QLVERGRtKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKE------------KRSRTITHYQFVSWPD-HGVPDEAGPALDFVREVHEVASS
.  .  . ... |||  . | |||| |....| . ..   |.||.||.               |.....|.  |.  . ||  .   ....| |. .   
ktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrek

A-----FGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
.      |||.|..| |..|.| ..|.   |. .. .. ||.|. .  .|..|......  .| .|   . .|
vdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0041856 (Phosphotyrosine protein) phosphatases II 905-1136 2.6e-54 178.9 In-house 1-171 (182) alignment 
Range on Protein: 905-1136
Range on HMM: 1-171/182.0
NRAKNRYTNILAYDHSRvklesiddepGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTqlvergrtkCHRYWPgaqpevyge
|. ||||..|| |||||          ..||||||.. |..  . .|||||||.||. ||.|| .|.. ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

invdmlseteksdwivrkfkitkEKRSRTITHYQFVSWPDHGVPDeAGPALDFVREVHEvassAFGPVIVHCSAGVGRTGTFIALGTLLQHikdhDwVDL
                       |.  |....|....||||||||    .|||..||.|      |||.||||||||||||..|.  ....    . |.|
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
.   ...|..|..|..|. ||.|.. |. . .
eeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 880-1132 2.3e-51 169.3 In-house 16-289 (301) alignment 
Range on Protein: 880-1132
Range on HMM: 16-289/301.0
KFSEEYEKVSAvGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESI--DDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIV
||.|.|....  | |.| . .|  ||.| ||. ||  ||. |. |.     |    .||||.|| ||. ....||.|||. .|  ||||. |..    ||
kfeeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKSD-----------------WIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFV
|.|.| |. ..||..||| .  . | .|...| . .|.   |                  | ||||....| |.... .| ..||..||  |    |  .
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

RE-VHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAM
 . .|   .   |||.||||..|.|.|.....   |   |    ||.|..   .|. .  ...|  ||..|....
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
0036282 (Phosphotyrosine protein) phosphatases II 932-1130 3.8e-51 168.5 In-house 1-164 (174) alignment 
Range on Protein: 932-1130
Range on HMM: 1-164/174.0
GSDYINANYIPGYRMRRAYIATQGPLPstfddFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGaqpevygeinvdmlseteksdwivrkfkiTKEKRS
|||||||... ...  . .||.||||.     ||.| .|......|||....|.|..||..|||                              ..|  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredle

RTITHYQFVSWPDHGVPDEAGpALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKdHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
|.. .|... |||||||| .   |.||..|.|. |.   |||.||||||||||||..|.  .|.... .. || . |  |.|..| .|.||. || |...
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0049772 (Phosphotyrosine protein) phosphatases II 894-1140 4.4e-50 166.5 In-house 35-284 (314) alignment 
Range on Protein: 894-1140
Range on HMM: 35-284/314.0
DHSKDASLLPENRAKNRYTNILAYDhSRVKLeSIDDEPGSDYINANYIPGYrmrRAYIATQGPLPSTFDDF----------WRMT--WEQNSHVIVM---
...  .. |..|| ||||..|| .| .||.| .  .  |||||||.|. |.   ...|||||||. |..||          |||.  ...|...|||   
eltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTQLVERGrtkchrywpgaqpevygeinvD--------MLSeteksdwivrkfKIT--KEKRSRTITHYQFVSWPDHGVPdE
                  |..| ..|                     .        .|             ...  .|. .|.. .|  . .||...|  
evladelsrLdaAlgKtpllildgng.....................neptaadlellk............eelydpelferlgikylripvpDgsap.l

AGPALDFVREVHEVasSAFGPVIVHCSAGVGRTGTFIALGTLLQHIkdhdWVDLFGLASEMRQHRN-----HMIQTEPQYVFIHKAMVDACKSSM
    ..|.. ..|.  .. |||.|||.||.||||||.... |. .     .|.|    ...|. |      ..|..  ||.||..|. ...|  .
ledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_ptpA1_pd Subfamily ptpA1 904-1096 5.5e-50 165.3 In-house 46-256 (418) alignment 
Range on Protein: 904-1096
Range on HMM: 46-256/418.0
ENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRmRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWP----GAQ-
 | .||||||||  .|.||.|. |.|. |||||||||| |    . .|.|||||| |  ||||| ||.  ..||||..  |  | || ||||    | | 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

------PEVYGEINVDMLSE--TEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE-----VAS-SAFGPVIVHCSAGVGRTG
       ||.|  .|...      . . | |. ..| |  .| ||.||.  |||| .|| . |  .... . .     . |     |.||||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TFIALGTLLQHI
|| .   .....
tfctavimmkkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 869-1133 3.1e-49 162.7 In-house 6-274 (307) alignment 
Range on Protein: 869-1133
Range on HMM: 6-274/307.0
YVEDMLNDAGFKFSEEYEKVSAVGLDHsKDASLLPENRAKNRYTNILAYDHSRVKLESidDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMT
.|.  |.    .. .|.....    .    .  .  |  ||||... . |..|. ..   |   |||| |||.      . .|..|||| .|  .|| |.
wvqrtldkgvqalvdefrvlakktpeg.vtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwama

WEQNSHVIVMLTQLVERGRTKCHRYWPGA--QPEVYGE----INVDMLSETE---KSDWI-VRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFV
 ...   ..|| ...| .. ||..|||    |  |.||    |.|. |   .     | | | ..|.   ..||||.|.|.  |||.|||.    |....
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll

REVHevasSAFGPVIVHCSAGVGRTGTFIALGTLLQH-IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
  |.        ||.|||||||||.|| .|.  . .  |.  .  |.  |  |.|..|.. |||| ||...|. ..
eavr....ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 897-1137 1.3e-47 156.9 In-house 46-284 (290) alignment 
Range on Protein: 897-1137
Range on HMM: 46-284/290.0
KDASLLPENR--AKNRYTNILAYDHSRVKLEsiDDEPGsDYINANYIPGyrMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYW
 . ... .|    |||| ..   | .|| |.  |  .| ||. |||. |  ..  .| |||.| .|  |.|||  ...  .|||| .|.| |..||..|.
lerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyy

PGAQPEV--YGEINVDMLSETEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDEAgpaLDFVREVHEVAsSAFGPVIVHCSAGVGRTGTFIAL
|  . ||  .||| |    |..| . |..|    ..    ..  . |.. .||||. |.  .   | ..| .. .   | |||.||||||.||||||.|.
pekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlrilr.kasGpvvvhcsaGiGrtGtfvai

GTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
 . || . |   .|| .|   .|. |   .| . ||. . ....|  |
evglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
0043147 (Phosphotyrosine protein) phosphatases II 930-1129 1.1e-46 154.0 In-house 2-154 (172) alignment 
Range on Protein: 930-1129
Range on HMM: 2-154/172.0
EPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLvergrtkchrywpgaqpevygeinvdmlseteksdwivrkfKITKEK
..|||||||.|...|.  . .|||||||..|..||||| .|.. ..||.||.|                                           ..|.
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpel

RSRTITHYQFVSWPDHGVPdEAGPALDFVREVHE-VASSAFGPVIVHCSAGVGRTGTFIALGTLLqhikdHDWvDLFGLASEMRQHRNHMIQTEPQYVFI
 .|.. .|....|||||||  .   |.|.. ..| .| |  |||.||||||||||||..|.  .|     ... .|.   ...|..|....|.. || |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrfl

H
.
y
0046846 (Phosphotyrosine protein) phosphatases II 928-1132 5.1e-46 151.9 In-house 7-169 (176) alignment 
Range on Protein: 928-1132
Range on HMM: 7-169/176.0
DDEPGSDYINANYIPGYRmrraYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYgeinvdmlseteksdwivrkfkitk
 .....||||||.| |.|    .||||||||.|. ||..| .|.. ...|.||..|| || ||..|||  . . .                         
gldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

ekrsrtitHYQFVSWPDHGVPDEaGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGtllqHIKDHDWVDLFGLASEMRQHRN-HMIQTEPQYV
        .|... ||||||||     |.......|. ..  |||.||||||.|||||..|.      .. .  ....   ...|..|  ...||. || 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIHKAM
|.....
flyefe
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 903-1135 6.6e-45 147.9 In-house 35-268 (281) alignment 
Range on Protein: 903-1135
Range on HMM: 35-268/281.0
PENRAKNRYTNILAYDHSRVKLES-IDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQP--
| |  ||||.|| . | |||.|.  . ..  .||| ||||    ..| || ||||   |  ||||| |..|.  |||| |..|  | ||  |.|      
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

EVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHevASSAfgPVIVHCSAGVGRTGTFIALGTLLQHIKDH
  . .. |.    | .   .  ..... |  .| |||. .  |||  ||. .   |  .|...  | |.  | ..||||||||.||..|.   || |. |
lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir..arst..ppvihcsagvgrsgtlmaveialqsihsh

D-WVDLFGLASEMRQ-HRNHMIQTEPQYVFIHKAMVDA
    |.  . | .|   |   .||  ||..| | ..| 
ftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0049260 (Phosphotyrosine protein) phosphatases II 940-1130 7.4e-44 144.4 In-house 1-144 (152) alignment 
Range on Protein: 940-1130
Range on HMM: 1-144/152.0
YIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWpgaqpevygeinvdmlseteksdwivrkfkitkekrsrtitHYQF
.|.||.| ...||||||.| |..||||| .|.. ..|||||.|.|.|. ||..|.                                         .|..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylh

VSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLqhikdhDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
. |||||||| .   |.... ... | .  |||.||||||||||||..|.  .|        |.|.   . .|..|....... |. |...
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 878-1137 9.8e-42 137.8 In-house 5-260 (267) alignment 
Range on Protein: 878-1137
Range on HMM: 5-260/267.0
GFKFSEEYEKVSAVGLDHSK-DASLLPENRAKNRYTNILAYDHSRVKLESIDDEpgsdYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVI
  .. .|.|..  .  ..|.   |.  .|...||. . | ||..|| |   ..|    |||| |. ||. ..|.|.||.||  |  ||. .  .|.  ||
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLTQLverGRTKCHRYWPGA--QPEVYGEINVDMLSETEKSDWIVRKFKIT-KEKRSRTITHYQFVSWPdhgVPDEAGPALDFVREV--HEVASSAFGP
|.||.    .  . ...||    | . | .. |.   | |. |. .  ...  |.. .. .| | .  |    .  .  | |  .  .  ..    .  |
vlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrP

VIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
..|.||.||||.|||. . . |. .|  . .|.| .  ..|. |  ...|  .|..||. ...  .
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 905-1051 1.3e-40 134.1 In-house 33-183 (297) alignment 
Range on Protein: 905-1051
Range on HMM: 33-183/297.0
NRAKNRYTNILAYDHSRVKLESIddEPGSDYINANYI--PGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV-
   ||||..|||.| .||||      ...|||||.|.  |       || .|||| .| ||||.. .||.  ||||...| | || ||  ||| .. |  
slrknryrdilatddtrvkllrv..iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

-YGEINVDMLSETEK--SDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEA
  |.. |. ||.|       |. ....   ..|| ..| ||.|||||||| . 
kagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 905-1134 1.9e-40 133.4 In-house 55-287 (305) alignment 
Range on Protein: 905-1134
Range on HMM: 55-287/305.0
NRAKNRYTNILAYDHSRVKLesiDDEPGSDYINANYIPGYRM-RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE---
. .||||... . |.| |||   |. . |||| |||.    .  . .|..||||  | |.|| |  ...   |||| . || |. || .||| || |   
aitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

VYGEINVDMLSETEKSD----WIVRKFKITK-EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHevaSSAfGPVIVHCSAGVGRTGTFIALGTLLQH
. . | |. .| .   .      .  ...|   ... .. | |.  ||| |||     .|...  .     |   |..||||||.||||| .|.  .|..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gsk.vpivvhcsagigrtgtivaieyilek

IKDHD-WVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
| .      .  |   .|..| . ||.. ||.|||. |..
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 894-1134 1e-39 131.0 In-house 41-288 (310) alignment 
Range on Protein: 894-1134
Range on HMM: 41-288/310.0
DHSKDASLLPENRAKNRYTNILAYDHSRVKLEsIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRY
| |       ..  ||||....  | |||||. ||     ||| |||.    .| ..| .||||  |  ||||| ... .  |..| . .| || ||  |
dssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPGA-QPEVYGEINVDMLSETEKSDWIVrKFKIT--------KE----KRSRTITHYQFVSWPDHGVPDEAGPALDfvreVHEVASSAFGPVIVHCSAGV
||     | || | |  |||. .   |. .. .|         |     .   ..  ..  ||| |||||   ..        .|    ||..||||||.
wpslgvtetygcirvtnlsesseefeic.nlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagk

GRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.|... .||   .....  . ||.  . .|....|   |||| ||..|.. .. 
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 904-1132 1.8e-39 130.5 In-house 42-267 (288) alignment 
Range on Protein: 904-1132
Range on HMM: 42-267/288.0
ENRAKNRYTNILAYDHSRVKLEsidDEPgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV--
.| ...||.|.   | .||||.   |.|   ||.|| ..  . .|  | .| || .| . .|.|  |.. . ||||..|.|.|. |   |.|  . |   
anptrdryenlprcditrvkls...ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGEINVDMLSETEKSDWIV--RKFKITKEKRSRT-ITHYQFVSWPDHGVPDEAGPALDFVREVhevaSSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKD
.| .  ..  . .  | .|    ..|.||   .  . .  .  |.|.|||..  . | ..  .     |   |..||.|||||||||.|     |. .. 
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrl

HDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAM
.| . .  | ...|..| . |||| ||...|. .
ddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 904-1137 1.4e-38 127.4 In-house 47-288 (305) alignment 
Range on Protein: 904-1137
Range on HMM: 47-288/305.0
ENRAKNRYTNILAYDHSRVKLESiddEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVY-
... |||| ..   |. |||||.       .|| |||.      . .| || ||  |  ||| | .... . | || .|.|.|  ||. |..  . .|  
qeagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

-G----EINVDMLSE-----TEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDeagpALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIAL
       | | . |      .....  |.. ... |   ...| .||| .. ||| |||     |   . |. | | .. ||..||||||.||||. . |
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa....adlailellekarpskgpivvhcsagigrtgsvvml

GTLLQHIKDHDWVDL-FGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
  .|. .   . ..    .   .|. ||  |||. ||.|.|. ... ..
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0044763 (Phosphotyrosine protein) phosphatases II 917-1130 3e-38 126.6 In-house 2-165 (178) alignment 
Range on Protein: 917-1130
Range on HMM: 2-165/178.0
YDHSRVKLESIDDEPGSDYINANYIPGYrmrrAYIATQGPlpstfDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPevygeinvdmlseteks
.|..||.|... ....||||||..| ..     |.....|      |.... .|.. ..||.||. .|.|. ||..|||                     
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

dwivrkfkitkekrsrtiTHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHikdhDWvDLFGLASEMRQHRN
                   .|... .|||||||     |.||. ..|. ..  |||.|||||||||.||..|.  ....    .. .|.   ...|..|.
..................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp

hMIQTEPQYVFIHK
 ..... |. ....
.ivpnpgqlrqLye
0051082 (Phosphotyrosine protein) phosphatases II 932-1131 5.7e-38 125.2 In-house 2-148 (151) alignment 
Range on Protein: 932-1131
Range on HMM: 2-148/151.0
GSDYINANYIPGYrmrraYIATQGPLPstfdDFWRMTWEQNSHVIVMLTQLVERGrtKCHRYWPGAQpevygeinvdmlseteksdwivrkfkitkekrs
 |||||..|. |.     .....|||.    ||... .|..  .||.|....|||  .|..|.| ..                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

RTITHYQFVSWPDHGVPDEAGPALDFVREVHEvasSAFGPVIVHCSAGVGRTGTFIALGTLLQHikdhdwVDLFGLASEMRQHRNHMIQTEPQYVFIHKA
....|.....|||.|.|.    .|.|.... .      |||.||||||.|||||..||  .|..      |.|.   .|.|..| ...|.. |..|...|
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 888-1128 2.6e-36 119.9 In-house 34-273 (301) alignment 
Range on Protein: 888-1128
Range on HMM: 34-273/301.0
VSAVGLDHS-KDASLLPENraKNRYTNILAYDHSRVklESIDDEPgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERG
|...  ||  .  . ||..  |.|| ..    .. |  | |.|      | ||.||     . .|||||||..| .||| |    . . ||||.| ||. 
vttidkdhitesyaylpkd..khryptvPckPstav..evivdGk.rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekl

RTKCHRYWPGAQPEVY--GEINVDMLSE--TEKSDWIVRKFKI---TKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVrevhEVASSAFGPVIVHCSAG
 .||. | |   .|    |  .. . ..    . . . |....   |..  .||.||||...|.|.|||       |..    |..  .  |..||||||
eekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm....elvkksekPivvhcsaG

VGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFI
.||. .||.   | .... .  ..|     ..|.|| . .||. |  ..
iGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
PTPc_DSPc_SM00012 1033-1133 5.6e-34 111.9 In-house 1-104 (105) alignment 
Range on Protein: 1033-1133
Range on HMM: 1-104/105.0
TITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF--GPVIVHCSAGVGRTGTFIALGTLLQHIKDH-DWVDLFGLASEMRQHRNHMIQTEPQYVFIH
|..||.. .|||||||.|. . |...|.|... . .   .||.|||||||||||||.|| .|||..... . ||.| . .|.|..|..|.||| ||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

KAMV
.|. 
rall
subfamily_CG42327_pd Subfamily CG42327 883-1064 5e-33 109.1 In-house 9-193 (319) alignment 
Range on Protein: 883-1064
Range on HMM: 9-193/319.0
EEYEKVSavGLDHSKDaSLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMR-RAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQ
||....    |  . |  . .  . |.|. |..   ..|| |..| |.. . |..|.|. ||.     |||.| .| ..  ||||. |||.| ||| ||.
eefrdlP..qliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LVERGRTKCHRYWPGA----QPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFvSWPDHGVPDEAGPALDFVREVHEV
| | |  .| .|.|      . ..||.| | .     |  ...  . .   ... || .||| .  |.. .|| |  . .  . ||.. 
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 881-1135 3.1e-31 103.2 In-house 21-275 (312) alignment 
Range on Protein: 881-1135
Range on HMM: 21-275/312.0
FSEEYEKVSAVGLDHSKDASLlpENRAKNRYTNILAYDHSRVKLESidDEpgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLT
.. ||  |  .  |    | |    .  ||| ||  .|  |  |    ||    || ||..        ...||||| .|   ||...    |  |..|.
ltkeykavgnivsdsectafl..kfkdlnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

QLVERGRTKCHRYWPGA-------QPEVYGEINVDMLSETEKSDWIV---RKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEvassAFG
 .|| |  || .|           .  || |   ..       | |     |  .    .   . |||. ||||||.||    || ..  |.        
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkk

PVIVHCSAGVGRTGTFIALGTL---LQHIKDHDWVDLFGLaseMRQHRNHMIQTEPQYVFIHKAMVDA
||| |||||||||||.. . ..   |.| .  .  | | |   .|. |   ... ||||.  ..... 
pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 905-1133 4.8e-31 102.8 In-house 35-267 (285) alignment 
Range on Protein: 905-1133
Range on HMM: 35-267/285.0
NRAKNRYTNILAYDHSRVKLESIDdepgSDYINANYI--PGyRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV-
|   |||... . . .|| |.  |     ||| |...  || . . .||.|||||| |. |||.| ....   ..||  |.| |  ||  |.|    || 
npdlnryadvrcieetrvvlknhd....rdyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

-YGEINV--DMLSETEKSDWIVRKFKITKEK--RSR--TITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGTLLQ
 .|. ..      |   .  |.  . ... .   |    . | |   |||.  |..| | ... . |..|      |. |||||||||| ||. .     
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyati

HIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.| .   .... .  |||  | . .|.  |..|..  ..
rimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_egg_pd Subfamily egg 887-1133 1.9e-28 94.0 In-house 26-267 (307) alignment 
Range on Protein: 887-1133
Range on HMM: 26-267/307.0
KVSAVGLDHSKDAsllpENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERg
 |  . | .. ..    .|. | |   .   | ||||||        |.| ||.. |  .   .| .| ||  | |||||| .... . |||||  .|  
svdeislttaasd....nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.

rTKCHRYWPGAQPE--VY--GEINVDMLSETEKSDWIV--RKFKI-TKEKRSRTITHYQFvswpDHGVPDEAGPALDFVREVHEVASsafgPVIVHCSAG
  .|. ||| |. .  |.  | .... |   .|.| .    |.|.   ..  | . |.|     |     .    |  .| . ...     ||.|..  |
.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnlsk....pvvvqdilG

VGRTGTFIALGTLLQHIKDHDW-VDLFG-LASEMRQHRNHMIQTEPQYVFIHKAMV
| ...|..|. . | ..        |       .|..|.  ...  .|.|... ..
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 905-1009 4.3e-28 93.0 In-house 47-162 (350) alignment 
Range on Protein: 905-1009
Range on HMM: 47-162/350.0
NRAKNRYTNILAYDHSRVKLE-S------I-DDEPGSDYINANYIP----GYRMRRA--YIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKC
  |||||.||| |.||||||. |      .     ..|||||||.     . ..     |||||.|||||.|||...  . . .||..||..|| .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HRYWPGAQpevYGEINVDM
.|||.  .   | .|.| .
yrYWqegs...ydditvkl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 947-1130 2.7e-27 90.3 In-house 4-198 (199) alignment 
Range on Protein: 947-1130
Range on HMM: 4-198/199.0
RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQP--EVYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFV
.| ||||| ||  |. |||.| ||  |  |||. .      .    ||| ..     || ..|   . | |.|. .  . .|.       .| |.|||| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDEAGpALDFVREVHEVAS----SAFGPVIVHCSAGVGRTGTFIALGTLLQHI--KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
|| ..  |. |   . ||    ||.         ||||||| | | || |.||   ..         |||| .|  .|| |  .| . ..| ||..
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 947-1130 3.3e-27 89.9 In-house 3-197 (198) alignment 
Range on Protein: 947-1130
Range on HMM: 3-197/198.0
RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQP--EVYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFV
.| ||||| ||  |. |||.| ||  |  |||. .      .    ||| ..     || ..|   . | |.|. .  . .|.       .| |.|||| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDEAGpALDFVREVHEVAS----SAFGPVIVHCSAGVGRTGTFIALGTLLQHI--KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
|| ..  |. |   . ||    ||.         ||||||| | | || |.||   ..         |||| .|  .|| |  .| . ..| ||..
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1015-1135 8.1e-26 85.3 In-house 74-193 (440) alignment 
Range on Protein: 1015-1135
Range on HMM: 74-193/440.0
KSDWIVRKFKitKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQ
.||.|   .   .   |||. .|.. .|||.|||  ||| | ....| |     . ||..||||||.||||  ||. ..|.. |  | .|.| . . ||.
dsdyinasyi..ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrn

HRNHMIQTEPQYVFIHKAMVDA
 | .|.||  ||.|.|.|....
nrpqmvqtpeqyafvheavleg
0048076 (Phosphotyrosine protein) phosphatases II 1024-1131 2.8e-25 84.1 In-house 37-138 (145) alignment 
Range on Protein: 1024-1131
Range on HMM: 37-138/145.0
KITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGTLLQhikdHDwVDLFGLASEMRQHRNHMIQTEP
  ..|  .|....|....|||||||| .   |.|.. ..|. ..  |||.||||||||||||..|.  .|.    .. |.|.    ..|..| ...... 
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpg

QYVFIHKA
|. |....
qlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 1025-1130 6.6e-24 79.7 In-house 40-139 (144) alignment 
Range on Protein: 1025-1130
Range on HMM: 40-139/144.0
ITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGTLLqhikDHDwVDLFGLASEMRQHRNHMIQTEPQ
  .|   |....|....|||||||| .   |.|.. ..|. ..  |||.||||||||||||..|.  ..     .. ..|.    ..|..| ...... |
yepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

YVFIHK
. |...
lrfLle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 899-1133 2.5e-22 74.4 In-house 13-256 (290) alignment 
Range on Protein: 899-1133
Range on HMM: 13-256/290.0
ASLLPENRAKNRYTNILAYdHSRVKLESIDDEPGSDYINANYIPgYRMRRAYIATQGPLP-------STFDDFWRMTWEQNSHVIVMLTQLVERGRT---
. .. ..  ..|... |.  ..|| |.       .||| ||..  .    . |.|| |.        ||  .|| |  . ... .||| .  |. .    
tdyvkkhemdqRlevpLve.atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

-KCHRYWPGAQPE--VYGEINVDMLSETEKSDWIVRKFKITKEK-RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHevASSAfgPVIVHCSAGVGRTG
  | .| | .  |   .. ..|   |  .. | ..|.  .. .. .  |.||.....| .  |...   .|. .. |.  || .  ||||||  |. |  
faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..askt..pvivHcvdGiSrsA

TFIALGTLLQHIK-DHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.. |.    | |   .. | |  . ...|..|...|... .. |.  ..|
alaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 956-1142 6.3e-22 72.4 In-house 99-291 (302) alignment 
Range on Protein: 956-1142
Range on HMM: 99-291/302.0
PLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV--YG-------EINVDMLSETEKSDWIVRKFKITKEK----RSRTITHYQFVSW
|  || . .| .  . |  ..| |...|| .  ||  |.     ..  .|       ... |.   |.| .  . . .|. ||      .|.   .| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPDEAGPALDFVREVHEVASSafgpVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIhkaMVDACKSSMSK
|||| |.|| .||| ..       .    |.||||||||||||..|.   .|  . ..  ||  .   .|| |   .|.| | ...   ..   |. | |
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl...llcvtkglmek
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 960-1127 1.1e-21 72.1 In-house 40-212 (255) alignment 
Range on Protein: 960-1127
Range on HMM: 40-212/255.0
TFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT----KEKRSRTITHYQFVSWPDHGVPDEAGPAL
| | |...   ....|.|||. . | |. ||..|.|  . |     .|.. .    .| ..|  .||    . |. .|..||..  |...  |..|   |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFVRevheVASSAfGPVIVHCSAGVGRTGTFIALGTLLQ----HIKDHDWV--DLFGLASEMRQHRNHMIQTEPQYVF
  ..    |.  .  .|.||||.|.||. .|.    . |     ..  . |  |   |  |.|..|.  |.|  |  |
nilk....vvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 905-996 6.6e-19 62.4 In-house 48-155 (349) alignment 
Range on Protein: 905-996
Range on HMM: 48-155/349.0
NRAKNRYTNILAYDHSRVKLESIDDEP--------------GSDYINANYI--PGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRT
  ||||| .|| |.||||||.     .                |||||||.  . . . . ||||| ||||| |||...   .. .... |..  | .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHRYWPG
||..||  
kcdiywqe
subfamily_hpo-7_pd Subfamily hpo-7 958-1127 1.1e-18 62.1 In-house 44-218 (263) alignment 
Range on Protein: 958-1127
Range on HMM: 44-218/263.0
PSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFVSWPDHGVPDEAGP
  | | |...   ....|.|||.   | |. || .|.|  . |     ||.. .   .|| ...  ....     |. .|..||... |...  | .|  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

ALDFVRevheVASSAfGPVIVHCSAGVGRTGTFIALGTLLQ----HIKDHDWV--DLFGLASEMRQHRNHMIQTEPQYVF
 |  ..    ||     ...||||.|.||.  |    .. |     ..  . |  |   |  |.|..|.  |.|  |  |
ilnilk....varns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 879-1132 2.7e-18 60.6 In-house 22-275 (303) alignment 
Range on Protein: 879-1132
Range on HMM: 22-275/303.0
FKFSEEYEKVSAVGLDHSKDaSLLPENRAKNRYTNILAYDHSRVKLEsiDdepgSDYINANYIPGYRMRRAyIATQGPLPSTFDDFWRMTWEQNSHVIVM
    .|.|||..    .      . .|  |||.....  |||.|||   |    | || |.|.     ..| | || ||. |  |||.|  ||. .....
niavnefekvvsylppsvsk.nqfvknmdknrfvdvicldhskvkls..d....ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvll

LTQLVERGRTKCHRYWPGAQPEVYGE---INVDMLSETEKSD-WIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPalDFVREVHEVASS-----AF
|    |  .   .  .|  |  .  |   | |  . . | .| | ..   ... .    .  ... .||   .| .. |   ||... .. |        
lltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysds

GPVIVHCSAGVGRTGTFIALGTLLQHI-KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAM
 | .    .|.||.|||  . |    . ..   .||      .|. | | .|   |. ...  .
tptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 881-1140 2.9e-18 60.3 In-house 28-289 (302) alignment 
Range on Protein: 881-1140
Range on HMM: 28-289/302.0
FSEEYEKVSAVGLDHSKdASLLPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIPGYRMRRAYIATQGPLPSTF---DDFWRMTWEQNSHVIV
  .|..|....  |  |  ..  .| .||. ... ..|. .||||   |    .|.||  .    ..|  | .| |  ..    ..|||| ....   .|
vkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MLTQLVERGRtKCHRYWP--GAQPEVYGEINVDMLSeTEKSDWIVRKFKI--TKEKRSR--TITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGP
.| .  |  .   . ..|    . . ||.. |      ||..  . .. |    |  |    .. | .  |... ||.. . .   . .|..  ..|  .
ilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikaden

VIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSM
...    |.|| |.|..| . ........ .    ..  .|. | .....  |||... |..   |  .
tvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1073-1137 2.9e-17 56.8 In-house 2-66 (69) alignment 
Range on Protein: 1073-1137
Range on HMM: 2-66/69.0
IVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
.||||.| ||||||||.   .  ||    ||.|     ||. |  |.  | .|.||| |.|.| |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_eak_pd Subfamily eak 904-1139 1.2e-16 55.1 In-house 51-308 (332) alignment 
Range on Protein: 904-1139
Range on HMM: 51-308/332.0
ENRAKNrYTNILAYDHSRVKLESIDDEPgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE--V
|.  .|   .|. ||.  |.| |   ..   ||||  .    . | || |  .  .    ||.|  ||.|  ||.| . || .  |  .|.|    |   
eavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDE------------AGpALDFVREVHEVASS----------AFGPvIVHCSAG
.| ..|.  .  ...   .|.....|   .  . ||..  | .  .|              .| .| ..    .. ||          .| | |. .. |
fGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevG.vlllivmksallsstlkkyihtppsfap.iiqsarG

VGRTGTFIALGTLLQHIkDHDWVDLFG---LASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
  |.|.|. .  |.. | |    .|.    |   ....|.| . .. |. ||.....|  .  
saraGvfvvidllirli.dnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1073-1137 1.5e-16 54.5 In-house 1-65 (69) alignment 
Range on Protein: 1073-1137
Range on HMM: 1-65/69.0
IVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
.||||.| ||||||||.   .  ||    ||.|     ||. |  |.  | .|.||| |.|.| |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
fn3 Fibronectin type III domain 85-167 3.6e-16 52.2 Pfam-A 2-85 (85) alignment 
Range on Protein: 85-167
Range on HMM: 2-85/85.0
SPSDVSYINISSTSIEVSWNPPTDFNGPNEGYVITYIRLESDT-ESMSTNRLTGTSFVIENLEKYEQYSVTVVAFTDKGPGASS
.|...| ....|||...||.||.| .|| .|| ..|   ..   .   |.  | ||.....|. . .|...| | ...| | .|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 859-946 4.4e-15 49.9 In-house 4-88 (440) alignment 
Range on Protein: 859-946
Range on HMM: 4-88/440.0
RKVYLRDFPSYVEDmlNDAGFKFSEEYEKVsAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRM
| . . ||  ||..  |     | .|.  .   || .  | . ||.|. |||| |||||||||| || .   | |||||| || |   
rpiivadfadyvqn..nrrsrafedewsll.psglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_CG42327_pd Subfamily CG42327 1066-1133 1.5e-14 48.4 In-house 244-312 (319) alignment 
Range on Protein: 1066-1133
Range on HMM: 244-312/319.0
SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDH-DWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
 . .||..|||| ||||||. ||    ......    ||.  | | .|. | . ..|  || ||.| . 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
fn3 Fibronectin type III domain 496-586 1.8e-14 46.8 Pfam-A 1-82 (85) alignment 
Range on Protein: 496-586
Range on HMM: 1-82/85.0
SAPDPVIVKRRNDTAIQVNWTRPAEPNGIILGYLIYYIGTKNNTgteysninvlIIINVTDPNTL-SYLITNLLADTQYFINVTAYTSAGLG
|||  . |. ...| ....|. |....| | || . |  . ..              ..| |.|  |. .|.| ..|.| ..|.|.. || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..........ewkeftvprtttsvtltgLkpgteYefrVqavngageg
fn3 Fibronectin type III domain 398-483 1.7e-11 37.3 Pfam-A 2-85 (85) alignment 
Range on Protein: 398-483
Range on HMM: 2-85/85.0
PPLDVSVIVDSPSTARISWSPPMyiDRNGIIVNYTVRIITTVRGT-IRETNISNVSGnYYDASDLPQFASFNVTVAAATSVGLGPYS
.| ..||.  .......|||||   |..| |..|.|.  ..  |   .| .... .   .  ..|   ......|.| . .| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 904-1028 2.5e-11 37.6 In-house 33-158 (332) alignment 
Range on Protein: 904-1028
Range on HMM: 33-158/332.0
ENRAKNRYTNILAYDHSRVKLESIDDEpgSDYINANYIPGYRMRRAYIATQGPLPST-FDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRY--WPGAQPE
.|   ||   . ..|||||.|   | .   |. ||... ||  . ||| .| |.       ||||  |..  .|... .. |. . |.       | .  
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeks

VYGEINVDMLSETEKSDWIVRKFKITKE
.  |.    | | |    |.|||   |.
flhefgaksleecelkakicrkfwpekr
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 915-1047 3e-11 37.8 In-house 3-126 (130) alignment 
Range on Protein: 915-1047
Range on HMM: 3-126/130.0
LAYDHSRVKlesiddepGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERgrtkcHRYWPGAQPEV-YGEINVDMLSET
| .. ||..        | .||||...      . |. || ||  |  |||.|  |.   |.|.|  . |        ||| ..|   | |  .  |.. 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

EKSDWIVR-KFKITKEKRS--RTITHYQFVSWPDHGV
.... |   ...| ..     ...| .|   ||  | 
defknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1066-1132 3.5e-11 37.4 In-house 259-340 (350) alignment 
Range on Protein: 1066-1132
Range on HMM: 259-340/350.0
SSAFGPVIVHCSAGVGRTGTFIALGTLLQ------HIKD-----HDWVDLFG----LASEMRQHRNHMIQTEPQYVFIHKAM
..   |..||||||||||||...|  ||.      ....     . .  ..     .  |.|. |  |.|.  |..||..|.
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 862-955 4.4e-11 36.8 In-house 6-95 (95) alignment 
Range on Protein: 862-955
Range on HMM: 6-95/95.0
YLRDFPSYVEDMLNDAGFKFSEEYEKVSAV-GLDHSKDASllPENRAKNRYTNILAYDHSRVKLESIDDepgSDYINANYIPGYRMRRAYIATQG
..  | |.| .|  ..  .| .|.  .|   |  ..  .|    |  |||. ||. || .|| | .  |   |||||| .. ||  . .|||.||
hvsvfhshvlemhsnsdqefdnefksismtsgapytvgss..eanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 181-267 4.7e-11 35.9 Pfam-A 2-84 (85) alignment 
Range on Protein: 181-267
Range on HMM: 2-84/85.0
PPSNVSTMS-TNTSISITWSPPLDPNGLLLSYSINVTLNSTYAqylsfDVMTMSVSQNIFSYTLFDLLPFAGYDISLQASTSVGLGTP
.|.|.|  . |.||....|||| |..| . .|.. .   ..       .  . .|. .  |.|| .| | . | ...|| . .| | .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 2-71 1.4e-10 34.4 Pfam-A 15-84 (85) alignment 
Range on Protein: 2-71
Range on HMM: 15-84/85.0
SLRITWTELLedDQNGVIIGYNISYFSLPAVG--QPINNFTSDTSYNISGLDVYTDYNVSVAAYTSAGTGPF
||...|..    |..| | ||.. | .    .  . ...  . ||....||  .|.|...|.|.. ||.||.
sltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 902-982 2.6e-10 33.5 In-house 24-77 (169) alignment 
Range on Protein: 902-982
Range on HMM: 24-77/169.0
LPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINAnyipgyrmrrayiatqgplpstfddfwRMTWEQNSHVIVMLTQL
|  | .||| .  ||  | ||||. . .. |||||||                           || || |. |||.| . 
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 902-982 3.1e-10 33.1 In-house 23-76 (169) alignment 
Range on Protein: 902-982
Range on HMM: 23-76/169.0
LPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINAnyipgyrmrrayiatqgplpstfddfwRMTWEQNSHVIVMLTQL
|  | .||| .  ||  | ||||. . .. |||||||                           || || |. |||.| . 
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt
fn3 Fibronectin type III domain 282-379 2.2e-09 30.5 Pfam-A 2-80 (85) alignment 
Range on Protein: 282-379
Range on HMM: 2-80/85.0
PVANPMASPVSSTAVNVSWLPPNlsNWNGLITNYTIEYRTNDEYIrpsievtatlssfansdDPRAATTPLQLESIIIPSLHEFVNYSFIITLSNSIG
.. |. .|.|.|| ...|| ||.  ...| ||.|..|||. ..                   ...  |.| . .| ... | .  .|.| ..  |  |
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.................ewkeftvprtttsvtltgLkpgteYefrVqavngag
0038934 (Phosphotyrosine protein) phosphatases II 1036-1129 2.3e-09 32.7 In-house 81-170 (194) alignment 
Range on Protein: 1036-1129
Range on HMM: 81-170/194.0
HYQFVSWPDHGVPDEAGPALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALgtLLQHIKDHdwvDLFGLASEMRQHRNHMIQTEPQYVFIH
.|    .||.|..      |.|.. |.|. .  . | | ||| ||.|||||..|    | .  .    ..      .|. |...|..  ..  ..
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa..YLiyrlgm...saeeAialfrekRpgaipnqdyleall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1071-1134 3.3e-09 31.0 In-house 230-293 (297) alignment 
Range on Protein: 1071-1134
Range on HMM: 230-293/297.0
PVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
...|||||||||.|  .   ..|. .. .   |   . | .|. |  ..||  |. ....|.. 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 943-996 3.5e-09 30.5 In-house 231-281 (440) alignment 
Range on Protein: 943-996
Range on HMM: 231-281/440.0
GYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERgrtKCHRYWPG
||  . |.|||| || ||  ||||.  . .   |.|| || ..    |  ||| 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 883-944 3.8e-09 30.5 In-house 17-77 (244) alignment 
Range on Protein: 883-944
Range on HMM: 17-77/244.0
EEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEpGSDYINANYIPGY
||.  .|    .  .  ..|  | .|||| ||| .|..|| | |   | |||||||||| | 
eefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgs
subfamily_PTPDC1_pd Subfamily PTPDC1 1031-1129 3.9e-08 27.9 In-house 80-169 (182) alignment 
Range on Protein: 1031-1129
Range on HMM: 80-169/182.0
SRTITHYQFvSWPDHGVPDeAGPALDFVREVHEVASSAfgPVIVHCSAGVGRTGTFIALGTLlqHIKDHDWVDlfgLASEMRQHRNHMIQTEPQYVFIH
 . |..|.| .|.|.||.     .|| |. |. . .     | ||| || ||||  ||   .  . |. .  .     . .|..| . |||  |  ...
eqgiyvynf.gwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvliacylv..yakrltaek...aiklvrskrpksiqtreqvelvk
PTEN_1 1028-1088 6.9e-08 27.5 In-house 89-149 (196) alignment 
Range on Protein: 1028-1088
Range on HMM: 89-149/196.0
EKRSRTITHYQFvSWPDHGVPDEAgPALDFVREVHEVASSAF--GPVIVHCSAGVGRTGTFIA
| . . .....| ...|||.|. .   .|......| ..|.   . |.||| ||.||.|| .|
effksgveylhf.pieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 906-972 1.2e-07 25.6 In-house 38-109 (347) alignment 
Range on Protein: 906-972
Range on HMM: 38-109/347.0
RAKNRYTNILAYDHSRVKLESI-----DDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQN
 .|||  .    | .|| |          ..   |||| .|     .. || || |||.|  |||.|    .
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 949-1047 5.2e-07 23.5 In-house 138-235 (244) alignment 
Range on Protein: 949-1047
Range on HMM: 138-235/244.0
AYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERgrtkcHRYWPGAQP-EVYGE-INVDMLSETEKSDWIVRKFKITKE--KRSRTITHYQFVSWPD
 || || ||  |  |||.|  |.   |.|.|  . |        ||| ..| | | | | | .    |  .    ...|  .  .  ...| .|   || 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

HGV
 | 
dgt
subfamily_CDC14_pd Subfamily CDC14 1049-1089 6.4e-07 23.5 In-house 243-283 (328) alignment 
Range on Protein: 1049-1089
Range on HMM: 243-283/328.0
DEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIAL
| . |    |..  |.| .| | ..||| ||.|||||.|| 
DGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1068-1099 1.4e-06 21.9 In-house 264-297 (349) alignment 
Range on Protein: 1068-1099
Range on HMM: 264-297/349.0
AFGPVIVHCSAGVGRTGTFIALGTLLQ--HIKDH
   ...|||||| ||||... |  ||.  .   .
qlstllvhcsaGcGrtGvlvtldlllsileplqn
Herpes_gE Alphaherpesvirus glycoprotein E 737-804 2.5e-06 16.1 Pfam-A 323-388 (439) alignment 
Range on Protein: 737-804
Range on HMM: 323-388/439.0
DDDSYVESQYSGPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRRKRKAYSfaAS
..|| ....   | ... .|....  ..  . ...|| ...||. .|..|...| |||.||||   ..
aadseesdppatpapsaepakpeartapyllllaavlgaavlllvvlllvlvcvtkrrrrkaye..kr
DUF4064 Protein of unknown function (DUF4064) 752-799 2.8e-06 15.4 Pfam-A 46-86 (100) alignment 
Range on Protein: 752-799
Range on HMM: 46-86/100.0
TdpiaeeNNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRrKRKAY
.      ..|.....  .|..|....... || |...|..|. |.| .
k......eetildllstlvlilgilaiilsilgiigsilvkk.kpkls
DUF912 Nucleopolyhedrovirus protein of unknown function (DUF912) 752-796 5.3e-06 16.9 Pfam-A 54-92 (101) alignment 
Range on Protein: 752-796
Range on HMM: 54-92/101.0
TdpiAEENNTGTTIVIAVVVVLLVIILLIAILVIVviiVLKRRKR
.   ||....  ...|....|| |..||..|. .|   .|..|..
k...aekaqatnillisllavlcvlvllyviyYFv...ilrerqk
Rifin_STEVOR Rifin/stevor family 742-797 5.9e-06 16.9 Pfam-A 231-286 (299) alignment 
Range on Protein: 742-797
Range on HMM: 231-286/299.0
VESQYSGPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRRKRK
.|..  . | .  .|  ...  ..  |...  ..|.. .....|.  | . |||.|
aeedvteaikkketalieskfaslttaIiasviailiIvlvmlIIylilrYRRKkK
m04gp34like Immune evasion protein 733-798 8.3e-06 11.6 Pfam-A 201-266 (272) alignment 
Range on Protein: 733-798
Range on HMM: 201-266/272.0
YNSDDDDSYVESQYSGPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRRKRKA
|.. |. ... ..|. .. | ..  ..|... . |. |.| |.|......| ..    | ||....
yevpdtlpkkrvaydyasetkredvsdnrallvtilsvivvllivvvllvLaylYgpsllrrlssr
Uroplakin_II Uroplakin II 720-793 9e-06 11.5 Pfam-A 109-180 (184) alignment 
Range on Protein: 720-793
Range on HMM: 109-180/184.0
LKPGTQYQFKYRVYNSDDDDSYVESqysgPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAIL--VIVVIIVLKR
| |||.|   |.| .    .|  |     |. | |  . .. | ..  .  .|.. ..| .|..  |. .|| |. 
lvpgtkyyisylvkkgastessrei....pmstlprknmesiglgmartggmvvitvllsvamfllvlgliialal
TMEM154 TMEM154 protein family 757-798 9.3e-06 17.0 Pfam-A 51-89 (146) alignment 
Range on Protein: 757-798
Range on HMM: 51-89/146.0
EENNTGTTIVIAVVVVLLVIILLiaiLVIVVIIVLKRRKRKA
..... . ..|..  |.|...||   .|....|. ||..|| 
sadqaelvlmiiiPsvvLillll...vvvilvikkkrkrrKq