Gene clr-1 in Caenorhabditis elegans

Synonym: CELE_F56D1.4, clr-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Ptp69D
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP046_AA protein Get Run
CeleP046_AA_810-1109 phosphatase_domain Get Run
CeleP046_AA_1152-1440 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Ptp69D_pd Subfamily Ptp69D 806-1129 3.4e-156 514.0 In-house 2-307 (307) alignment 
Range on Protein: 806-1129
Range on HMM: 2-307/307.0
GAIPVDDLPTEYVVRHRDTDFLFAQEYESLP--HFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVD
|||..|||......|.|||||..|.|||.|.  .....|..|..||||.||||.||.|||.||||||||||...||||||.|||..|||| |||||.||.
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDVipngngveyanvpivkgqfaNNS
|||||||||..|||..||||..|||||||..||||||.|....||||.|...|...||||.||..|.....|....|                    ..|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev....................eds

RRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKA
|...|||.|.|.|.|.||...|||......|||...|.||.|.||||||||.|.|...||.|.|. ||||..|||.|..||.||||.|||||||||.|.|
rkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyra

LAEWHMYGDTDEDVRDFEDHYQRLCA
|.....||||||||.|.||...|||.
lldyssygdtdedvddledaierlck
subfamily_Ptp69D_pd Subfamily Ptp69D 1150-1442 3.7e-123 405.5 In-house 2-289 (307) alignment 
Range on Protein: 1150-1442
Range on HMM: 2-289/307.0
PRVAIVSSRESMTTSNGET--GLEEEFKKLERNlTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGY--FFDYIAAQDPV
...||....|........|  ||..|..|||.. ....|.....|.||.||||||....|||.||.|....|..||.|||||.||||  ....|||||||
gaiaiddleealksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv

sEGTAFDFWRMIADQNVTTVVMLSDETDWSD--VEKYWPIDgsgTECHFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNES--MPANQEVVQYSYTGW
 |.|..|||||||.|.||..||||..|....  ..|||||.   .|...|    ...|..||||.|.|.|||.|..|.|..||  ......||||.||||
.eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devqyg....dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgW

PsDSIVPKSANSLMNLIEMV--LQRQSslmgsQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
. ||.||..|..|..|||.|  |....     ..||||||..|...||||.....|. ..|||...|.|.|||.|.|.|.......|||.|.||||.||.
k.DskvPevargllklieqvrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

SKT
|..
syg
subfamily_PTPRD_pd Subfamily PTPRD 807-1137 7.9e-108 356.5 In-house 4-310 (564) alignment 
Range on Protein: 807-1137
Range on HMM: 4-310/564.0
AIPVDDLPTEYVVRHRDTDFLFAQEYESLPHF-QLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDAT
.|||..|.. .   . . |. | .||... .  |  . |.| ..|  ||||..| |.| .||.|.|..||. ||||||.||......| .||.|.|.  |
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaet

IGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGecgpdvipngngveyanvpivkgqfANNSRR
| |||||||||.|  |||. .| ||....|.||||... ..||...|.. .    .|| || | . .                            ..|| 
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk.........................ssesre

ILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALA
. |.|||.| |  .||  |.||... . |.| . .. |.|.||||||||||||| ||.||..  .|.. .|...| .||.||| |||. |||.||..|..
VrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheail

EWHMYGDTDEDVRDFEDHYQRLCASNRDRAVS
|    |.|. .......| |.|   ..|  ..
ealacgntevesenlkqhlqkLaeveedtemt
0051299 (Phosphotyrosine protein) phosphatases II 807-1108 7.3e-90 296.6 In-house 4-286 (288) alignment 
Range on Protein: 807-1108
Range on HMM: 4-286/288.0
AIPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQ--LDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDA
.|.|..|   .  ....   ....|.| |....  |.. |....||  |||| || ..|..||||. ..|.. ||||||..|. .. |. |||.|.| . 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGpdvipngngveyanvpivkgqFANNSR
|..|||||||||.. .|||. .|.|..|..||.|||... . |||| |.  |   ..|| .| . . ...  .                     . ..||
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld.....................gdgesr

RILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKAL
.. ..|.||| |. .|.  . ||.|. ..|.  . ...|||.||||||||||||| .| .|.| ..| . ...|.|. ||.||. |||..|||.|.|.||
tvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal

AEWH
.|. 
leyl
0050432 (Phosphotyrosine protein) phosphatases II 819-1113 1.1e-87 289.5 In-house 35-304 (308) alignment 
Range on Protein: 819-1113
Range on HMM: 35-304/308.0
VRHRDTDFLFAQEYESLPHFQL--DTVASNRKENAIKNRYNDIRAFDDTRVKLkkingDDYSDYINANFIKSW--KEKKLFIAAQAPVDATIGDFWRMVW
. . .   |. .|.| |....   .. .....||  |||| || ..| .||||     |. ||||||.... .  | .. |||.|.| . |..|||||||
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

EQESYLIVMVANLTEKNRQQCAKYWPDE---QITRYGDIIVEPASFSFHSDYAIRAFDIAHIGecgpdvipngngveyanvpivkgqfANNSRRILQYHF
||.. .|||. .|.|..|..||.|||.|   ....||.. |.  |   ..|| .| . . ..|                          ..||.. ..|.
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.........................dgesrtvthfhy

TNWNDYKAPECSTGLLRFMYRLRELPqfNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYG
||| |...|.  . ||.|. ..|.    ...|.|.||||||||||||| .| .|.|  .| . ..|| |. ||.||. |||..|||.|.|.||.|. .. 
tnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

DT
 |
lt
Y_phosphatase Protein-tyrosine phosphatase 850-1106 1.3e-85 282.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 850-1106
Range on HMM: 1-235/235.0
NAIKNRYNDIRAFDDTRVKLkkiNGDDY-SDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWP--DEQITR
|  ||||.|| ..|.|||||   .|..  |||||||..|..|||| |||.|.|.. ||.|||||||.... .|||...|.||.|..||.|||  .|. ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIIVEPA-SFS-FHSDYAIRAFDIAHIGECGpdvipngngveyanvpivkgqfanNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPV
|||| ||   . .  ...|..| ... . .|                          ..|.. |.|.|||.|...||....||... ....  . ...||
ygdikvelkekekedekeytlrklelkkkkees........................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpv

VIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAE
|.||||||||||||...| .|.|. ||.. .....|..||.||. ||||||||.|.|||..|
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 850-1106 1.3e-85 282.0 In-house 1-235 (235) alignment 
Range on Protein: 850-1106
Range on HMM: 1-235/235.0
NAIKNRYNDIRAFDDTRVKLkkiNGDDY-SDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWP--DEQITR
|  ||||.|| ..|.|||||   .|..  |||||||..|..|||| |||.|.|.. ||.|||||||.... .|||...|.||.|..||.|||  .|. ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIIVEPA-SFS-FHSDYAIRAFDIAHIGECGpdvipngngveyanvpivkgqfanNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPV
|||| ||   . .  ...|..| ... . .|                          ..|.. |.|.|||.|...||....||... ....  . ...||
ygdikvelkekekedekeytlrklelkkkkees........................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpv

VIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAE
|.||||||||||||...| .|.|. ||.. .....|..||.||. ||||||||.|.|||..|
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0040438 (Phosphotyrosine protein) phosphatases II 821-1129 2.2e-85 282.0 In-house 13-297 (317) alignment 
Range on Protein: 821-1129
Range on HMM: 13-297/317.0
HRDTDFLFAQEYESLPHFQLDT-VASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESY
..    .. .|.| |....|||   ....||  |||| ||  .|..||||. ..||  ||||||.... ...|. |||.|.| . |..||||||||| . 
lksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

LIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfaNNSRRILQYHFTNWNDYKA
.|||. .|.|..|..||.|||... . |||..|.  |.  .... .| . . . |.                         ..||.. ..|.|.| |...
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgd.........................sesrtvthfhytgWpdhgv

PECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYGDTDEDVRD
|.  . ||.|. ..||  . ...||..||||||||||||| .. ||.|.  | . ...| |. ||.||. .||..|||.|.|.||.|......|.|.. .
ppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepase

FEDHYQRLCA
.  ....|..
lklkllklli
0046845 (Phosphotyrosine protein) phosphatases II 828-1113 2.7e-84 278.2 In-house 2-279 (284) alignment 
Range on Protein: 828-1113
Range on HMM: 2-279/284.0
FAQEYESLPHFQL----DTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGD-DYSDYINANFIKSW-----KEKKLFIAAQAPVDATIGDFWRMVWEQE
. .|.| |....     .. .....||  |||| || ..|..||||| ..|| . ||||||.... .     . || |||.|.|.. |..|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SYLIVMVANLTEKNRQQCAKYWPDEQ-ITRYGDIIVEPASFSFHSDYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfANNSRRILQYHFTNWND
. .|||. .|.|..|..||.|||.|.   .|||..|.  |   ..|| .| . . ..|                          ..||.. ..|.|.| |
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy........................tgesrtvthfhytswpd

YKAPECSTGLLRFMYRLRELPQ--FNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAED---KANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYG
...|. .. ||.|.  .||| .   ...|.|.||||||||||||| .| .|.|  .|.   . ...| |. ||.||. |||.||||.|.|.||.|. ...
hgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

DT
 |
lt
0036941 (Phosphotyrosine protein) phosphatases II 826-1119 2.3e-82 271.9 In-house 13-288 (297) alignment 
Range on Protein: 826-1119
Range on HMM: 13-288/297.0
FLFAQEYESLPHFQ--LDTVASNRKENAIKNRYNDIRAFDDTRVKLkkinGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVM
 |. .|.|.|....   .. .....||  |||| || ..|.|||||    .|. ||||||.... .. |. |||.|.| . |..||||||||| .  |||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

VANLTEKNRQQCAKYWPDE--QITRYGDIIVEPASFSF--HSDYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfaNNSRRILQYHFTNWNDYKA
. .|.|..|..||.|||.|  .   |||..|.  |..   ..|| .| . . ..|.                         ..||.. ..|.|.| |...
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn.........................gesrtvthfhytgwpdhgv

PECSTGLLRFMYRLRELPQF--NNSPVVIHCSAGVGRTGTFISIDSMLDQCL---AEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYGDTD
||. . ||.|. ..|.  .   ...||..||||||||.|||| .| ||.|      | . .|.|.|. ||.||. .||.||||.|.| ||.|. ....|.
pespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk

EDVRD
| ...
epllk
0047943 (Phosphotyrosine protein) phosphatases II 819-1107 4.2e-81 267.7 In-house 5-271 (273) alignment 
Range on Protein: 819-1107
Range on HMM: 5-271/273.0
VRHRDTDFLFAQEYESLPHFQ--LDTVASNRKENAIKNRYNDIRAFDDTRVKLkkinGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQ
.....   |...|.| |. ..  |.. .....||  |||| || ..|..||||    ||. ||||||.... .. |. |||.|.| . |..|||||||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

ESYLIVMVANLTEKNRQQCAKYWPDEQ---ITRYGDIIVEPASFSFHSDYAIRAFDIAHIGecgpdvipngngveyanvpivkgqfANNSRRILQYHFTN
 . .|||. .|.|..|..||.|||.|.    ..||...|.  |   ..|| .| . . ..|                          ..|| . ..|.|.
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.........................tgesrtvthfhytg

WNDYKAPECSTGLLRFMYRLRELPQF--NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
| |...|.  . ||.|.  .|.  .   .|.|||.||||||||||||| .| .|||  .| . ...| |. ||.||  |||..|||.|.|.||.|.
wpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 806-1112 1.4e-80 266.2 In-house 12-293 (297) alignment 
Range on Protein: 806-1112
Range on HMM: 12-293/297.0
GAIPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKING-DDYSDYINANFIKSWKE-KKLFIAAQAPVD
  ||.. |.  . .....   |. .|.|.|. .. |.. ....||  |||| || ..|..||||| ..| |  ||||||.... ..  .. |||.|.| .
ipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

ATIGDFWRMVWEQESYLIVMVANLTEKNRqQCAKYWPDEQItRYGDIIVEPASFSFHSDYAIRAFDIahigecgpdvipngngveyanvpivkgQFANNS
 |..||||||||| .  |||. .|.|..| .||.|||.|.  .|||. |.  ..  ...| .| . .                           .  . |
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlev...........................tnnges

RRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF--NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIY
| . ....|.| |...|.... ||.|.  .||  .   .. ||..||||||||||||| .. ||.|.  | . ...| |. ||.||. .||...||.|.|
rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly

KALAEWHMYGD
.||.|. ....
dallellkrkl
subfamily_PTPRG_pd Subfamily PTPRG 808-1114 2.8e-79 261.8 In-house 1-293 (563) alignment 
Range on Protein: 808-1114
Range on HMM: 1-293/563.0
IPVDDLPTEYVVRHRDTDFLFAQEYE----SLPHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYS-DYINANFIKSWKEKKLFIAAQAPV
.||...    .  | |.|  |..|.|       . .||. .|...||  |||| .| |.| .||||... | . . ||||||.|. .. .| |||.| |.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

DATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRafdiahigecgpdvipngnGVEYANVPIVKGQFANN
  |. |||||.|||.. .|||..||.|..|..|  ||| ..  .|| . |   .   .. |..|                    .   |. . |.. ...
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr...................tlviknlklkkkkqcdt

SRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYK
 ... |||.|.| |  .|| |.  | |. .     . .  |.|.|||||||||||.| .|..| |  .|.. |.|.|.  .| ||| .||. |||.|...
eklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd

ALAEWHMYGDTD
|| |. . ..|.
alleaiaskete
DSPc_SM00195 830-1107 3.2e-79 261.3 In-house 4-261 (263) alignment 
Range on Protein: 830-1107
Range on HMM: 4-261/263.0
QEYESLPHFQ--LDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANL
.|.|.|   .   .|  ...|.|  ||||..|  .|.|||||||..... |||||||.||  ..|| .||.|.| . |. ||||||||... .|||. . 
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

TEKNRQQCAKYWPDE--QITRYGDIIVEPASFSFHS-DYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfaNNSRRILQYHFTNWNDYKAPECST
 |.....|..|||.|  . ...|.| |.  .   .. .. .| . . . |.                         ...|.. ||...||.| ..|.  .
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.........................eetrkvtqyqyknWpdhgvpdstk

GLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
 .|...  ...  . ...|.|.||||||||||||..||..|... .|.| .||| |..|| ||  |||.|||| |||.|..|.
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 830-1107 3.2e-79 261.3 In-house 4-261 (263) alignment 
Range on Protein: 830-1107
Range on HMM: 4-261/263.0
QEYESLPHFQ--LDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANL
.|.|.|   .   .|  ...|.|  ||||..|  .|.|||||||..... |||||||.||  ..|| .||.|.| . |. ||||||||... .|||. . 
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

TEKNRQQCAKYWPDE--QITRYGDIIVEPASFSFHS-DYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfaNNSRRILQYHFTNWNDYKAPECST
 |.....|..|||.|  . ...|.| |.  .   .. .. .| . . . |.                         ...|.. ||...||.| ..|.  .
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.........................eetrkvtqyqyknWpdhgvpdstk

GLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
 .|...  ...  . ...|.|.||||||||||||..||..|... .|.| .||| |..|| ||  |||.|||| |||.|..|.
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0045450 (Phosphotyrosine protein) phosphatases II 808-1107 4.2e-79 261.8 In-house 9-303 (307) alignment 
Range on Protein: 808-1107
Range on HMM: 9-303/307.0
IPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQL----DTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGD-DYSDYINANFI--------KSWKEKKL
|.. .|  .. ....|   ....|.|.|....     .. .....||  |||| || ..|.|||||. ..|. . ||||||...        .... |. 
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDE-QITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGpdvipngngveyanvp
|||.|.| . |. |||||.||| . .|||. .|.|..|..||.||||| .   ||.. |.  |.. ...| .| . . . ...|                
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg................

ivkgqfanNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF--NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDK---ANIFEFVCNLRRQRN
        .||.. ..|.|.| |...|.    ||.|. ..|.  .   ...||..||||||||||||| .. ||.|  .| .    ...| |. ||.|| 
........esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRp

LMVQSLEQYVFIYKALAEW
 .||..|||.|.|.||.|.
gavqnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 808-1107 2.3e-78 258.8 In-house 2-276 (278) alignment 
Range on Protein: 808-1107
Range on HMM: 2-276/278.0
IPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLDTV-ASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATI
|.| ||.  .. ....   |. .|.|.|..|.|||   ....||  |||| || ..| .||||. ..||  ||||||.... .. .. |||.|.| . |.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

GDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPdEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECgpdvipngngveyanvpivkgqfanNSRRI
.||||||||. .  |||. .|.|..|..||.||| .. ..|||. |.  ..  ..|| .| . . . |.                          .|| .
edFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdg.........................esrtv

LQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAE
..||...| |...||  . ||.|. ..||  . .|.||..||||||||||||| .. .|.|   | . ...| |. ||.||  .||...||.|.|.||.|
thyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

W
.
y
subfamily_PTPRK_pd Subfamily PTPRK 808-1126 3.8e-77 254.2 In-house 4-295 (314) alignment 
Range on Protein: 808-1126
Range on HMM: 4-295/314.0
IPVDDLPTEYVVRHRDTDFLFAQEYESLPHFqldTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIG
| |.||  .  . .|   . | .|||||.       |....||  |||..|| |.| .||.|. |.||  ||||||..| |.|  . ||..| |.. |. 
irvadllqsiallkraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITrYGDIIVEPASFSFHSDYAIRAFDIAHigecgpdvipngngveyanvpivKGQFANNSRRIL
||||.|.....  |||...|.|. | .| ||||..  . |||| ||  . . .... .| | . .                         .  .. | . 
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrvek.......................largqeeirevr

QYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
|..|..| |.. |   ||||... |. .  . .. ..|.||||| ||||||| ||..||    |.  ..|. | .|| ..  ||.  |||.||| .. | 
qfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea

HMYGDTDEDVRDFEDHYQR
 . |.|   | .|.  |  
clcgetaipvsefkalyle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 807-1138 6.5e-76 250.3 In-house 5-309 (315) alignment 
Range on Protein: 807-1138
Range on HMM: 5-309/315.0
AIPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLDTVASNRK-ENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDAT
 ||.|.| |    ..  |   | |.|||.|  ||  .   .| ||  |||| .| |.| .||.|  .. |. |||.|||||. .. |. .||||.|  |.
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

IGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITrYGDIIVEPASFSFHSDYAIRAFdiahigecgpdvipngngveyanvpivKGQFANNSRR
..||||.|.|..   |||..|| |...... |||||.... || | |   |   ...|..|..                              | .| | 
vkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yGkitvtrkseevnteytvrtl...........................svvfgdnire

ILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALA
..|.|.| | | . |. .. |. .. . .   . . ...|.|||||||||||||..|..|||  ||.  ....|. ..|..|  |||..||| |||.|| 
vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

EWHMYGDTDEDVRDFEDHYQRLCASNRDRAVSF
|  . |||    . . ..|. | | . |   ..
etfvcgdtsiaqdlylqrydsllapspdtgstl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 822-1106 1.1e-73 242.9 In-house 17-277 (288) alignment 
Range on Protein: 822-1106
Range on HMM: 17-277/288.0
RDTDFLFAQEYESLPHFQL--DTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESY
...   | .||.||. ..   .. |... .|| ||||..| ..| .|||||| .  . .|||||..|.. |.|| .||.|.|. .|..|||..|.|... 
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

LIVMVANLTEKNRQQCAKYWPDEQI-TRYGDIIVEPASFSFHSDYAIRAFDIAhigecgpdvipngngveyanvpivkgqFANNSRRILQYHFTNWNDYK
 |||...| |.....| .||||..  ..||.. |.  .     |.  | . .                              .. ..| ||... | | .
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...........................kkkteleitqyqylaWpdhg

APECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAE
 || .. || ... .    | .  |...|||||||||||||..| ..|.  .||. .....|..||.||.|.|| |.||.|||..|..
vPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0045098 (Phosphotyrosine protein) phosphatases II 836-1112 1.8e-73 242.7 In-house 19-276 (278) alignment 
Range on Protein: 836-1112
Range on HMM: 19-276/278.0
PHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKlkkingddysDYINANFIKSWkeKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQC
...  .   ... .|. |||| || ..| .|||          |||||..|...  .| |||.|.| . |. |||||.||. .  |||...|.|..|. |
lgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

AKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDvipngngveyanvpivkgqfaNNSRRILQYHFTNWNDYKAPECS--TGLLRFMYRL
|.|||...  .|||. |.  |.. ..|| .| . . ..    .|                     . || . ..|...| |. .|. .  . .|... ..
aqywpeggsltygdftvtllseevlddytlrtllvtnltvered.....................lesrgvthlhylpwpdhgvpslpilksflellefi

RELPQF-------------NNSPVVIHCSAGVGRTGTFISIDSMLDQClaEDKANIFEFVCNLRRQRNL-MVQSLEQYVFIYKALAEWHMYGD
||  ..             .. ||..|||||||||||.. .. ||...  |.. ...| |. ||.||.  .||.||||.|.|..|.|....|.
realkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0040439 (Phosphotyrosine protein) phosphatases II 843-1108 5.5e-72 237.6 In-house 4-246 (249) alignment 
Range on Protein: 843-1108
Range on HMM: 4-246/249.0
VASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDE
  ....||  |||| || ..| .||||. ..|   ||||||..|. .. |. |||.|.| . |..|||||.||. .  |||. .|.|..|..||.|||..
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

QITRYGDIIVEPASFSFHSDYAIRAFDIAHIGecgpdvipngngveyanvpivkgqfANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF--N
. . |||. |.  |.  ..|| .| . . ...                          ..||..|....|.| |...|.    ||.|. ..|.  .   .
gsleygdftvtllsvevkddytvrtleltnly.........................dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpk

NSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWH
..||..||||||||||||| .. ||.|   | . ...| |. ||.||. .||..|||.|.|.||.|. 
ggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 846-1107 4.6e-71 234.4 In-house 5-242 (245) alignment 
Range on Protein: 846-1107
Range on HMM: 5-242/245.0
NRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQIT
...||  |||| || ..|.|||||. ..||  ||||||....  . .. |||.|.| . |..|||||.||. .  |||. ...|..|..||.|||.....
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

RYGDIIVEPASFSFHSDYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfaNNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQ-FNNSPV
.|||..|.  |.  ..|| .| . . ..|.                         . || ...||...| |...|. .  ||.|. ..|.  .  .| ||
tygdftvtllseehlddytvrtlevtnlgd.........................desrevihyhylpwpdhgvpdllellldflefvrkalaedsngpv

VIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
..||||||||||||| .. ||.|  .| . ...| |  ||.||  .||...||.|.|.||.|.
lVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 817-1114 5.3e-71 234.3 In-house 12-289 (305) alignment 
Range on Protein: 817-1114
Range on HMM: 12-289/305.0
YV-VRHRDTDFLFAQEYESLPHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWE
|.   . ..|  . ..|.||.. .  .   ....|. |||...|  .|| |..|.. . .| ||||||......|.|| .|.||.|.. |. ||||...|
yikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrlive

QESYLIVMVANLTEKNRQQCAKYWPDEQIT--RYGDIIVEPASFSFHSDYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfANNSRRILQYHFTN
     |||...| | ....| .|||...    ..|...||  |..  ||| .| . |.   |                         ..|| .|||..|.
ekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede........................dkesrtvlqyqltd

WNDYKAPECSTGLLRFMYRLRELPQFN-NSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYGD
| |   |. .| ||... |...  . . . |...||||||||||.||..| .|... .|.  ..|| . .||..|  |||.|.||||.. ||.|    ||
WPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

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|.
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subfamily_PTPRD_pd Subfamily PTPRD 1162-1441 1.1e-70 233.9 In-house 17-283 (564) alignment 
Range on Protein: 1162-1441
Range on HMM: 17-283/564.0
TTSNGETGLEEEFKKLERNltTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIAD
  .|... .|||.||.|..  .  . . |.|..|  ||||.  |..|. ||.| .. |. .| |||||.|.||     |||.| |..| |  |||||. .
lkansdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae.tiedFWRmvwe

QNVTTVVMLSDETDWSD--VEKYWPIDgSgtECHFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNESMpanQEVVQYSYTGWPsDSIVPKSANSLMNL
||..|.|||.   ...   ..|||| . .  ....|    .. || ..||. .|..||... ..|.....   .|| |. .| || |. ||.||.||..|
qnsstiVmltkleEkgkvkchkYWPek.g..tetyg....eltVtleeeeeladyeirtfklkkkksses...reVrqFhFtsWP.dhgvpesatslLdl

IEMVLQRQSslmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
|. | . ..     . |||||| .|   .|.|| |. .. | |.|. .|..|.|| |...|..|  . |||.|...|.......
irkvralne...pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0051299 (Phosphotyrosine protein) phosphatases II 1162-1439 7.1e-69 227.8 In-house 17-286 (288) alignment 
Range on Protein: 1162-1439
Range on HMM: 17-286/288.0
TTSNGETGLEEEFKKLERNLTTpLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIAD
.. || |||.|||..| ..|.. |. ..|.. ||| ||||   .|.|. ||.| .. |. .|.|||||.|.|| .   .||.| | .. |  |||||. .
llangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn.tvedFWrmvwe

QNVTTVVMLSDETDW--SDVEKYWPIdgsGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKD-NESMPANQEVVQYSYTGWPsDSIVPKSANSLMN
|||...||| .....   . ..|||    |.   .|     . ||..|||...|...|.|  . .|  .     ..| .. ||.|| |  || |...|..
qnvrvIvmltklvelgrekcaqYwpl...ggsltygd....itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellld

LIEMVLQRQSslmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
....| . ..    .. |.||||..| . .| ||.. ||. . ..|...||...|| | ..||.|.. .||| |.|.||..|.
flrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1159-1441 9.7e-69 227.4 In-house 33-301 (308) alignment 
Range on Protein: 1159-1441
Range on HMM: 33-301/308.0
ESMTTSNGETGLEEEFKKLERNLTtPLSSNFAAKDENLLKNRYEAAVPFDKYRVILpptigHADSSYINASHIKGY----FFDYIAAQDPVSEgTAFDFW
. .   .. ..|||||..| .. . .|. ..|.. ||  ||||   .|.|. ||.|     . .|.|||||...||       .||.| | .. |  |||
kllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn.tvedFw

RMIADQNVTTVVMLSDETDW--SDVEKYWPIDGSGTECHFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNESMpanQEVVQYSYTGWPsDSIVPKSAN
||. .|||...||| ....      ..||| .  |.  ..|     . ||..|||...|...|.|  ...... .    .| .. ||.|| |  || |..
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseevlddytvrtleltnlgdges...rtvthfhytnWp.dhgvPpspe

SLMNLIEMVLQRQsslmgSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
.|....|.| ...     .. ||||||..| . .| ||.. ||. . ..|...|||..|| | ..||.|.. .||| |.||||..|...
illdflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0047943 (Phosphotyrosine protein) phosphatases II 1161-1439 4.8e-67 221.6 In-house 5-272 (273) alignment 
Range on Protein: 1161-1439
Range on HMM: 5-272/273.0
MTTSNGETGLEEEFKKLeRNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILpptiGHADSSYINASHIKG--YFFDYIAAQDPVSEgTAFDFWRMIA
.....| |.|.|||..| ..|...|. ..|.. ||. ||||   .|.|. ||.|    |. .|.|||||...|  .   .||.| | .. |  |||||. 
lekllgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpn.tvedfwrmvw

DQNVTTVVMLSDETDW--SDVEKYWPIDGSGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNESmpaNQEVVQYSYTGWPsDSIVPKSANSLMN
.|||...||| ....    . ..||| .| ...  .|     . ||..|||...|...|.|  ......      .| .. ||||| |  || | .||..
eqnvrviVmLtelvelgrekcaqYwpleggelsltygk....ftvtllseetkddytvrtleltnlgtge...srtvthfhytgwp.dhgvppsleslle

LIEMVLQRQSSLMGSqAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
.||.| . ...|...  |.||||..| . .| ||.. ||. . ..|...||...|| |.|.||.|.. .||| |.|.||..|.
fielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 828-1107 6.2e-67 220.7 In-house 28-296 (306) alignment 
Range on Protein: 828-1107
Range on HMM: 28-296/306.0
FAQEYESL----PHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKkINGDDYSDYINANFIK-SWK-EKKLFIAAQAPVDATIGDFWRMVWEQESYLI
| .|.|.|     . .|.   ....||. ||||. |  ||.|||.||  ..   |||||||.|| ..| ..| .||.|  ...|. |||||||...| .|
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi

VMVANLTEKNRQQCAKYWPDEQIT-RYGDIIVEPASFSFHSDYAIRAFDIAHIgecgpdvipngngveyanvpivkgQFANNSRRILQYHFTNWNDYKAP
||. . .|.....||.|||||. . .||.| |.  | . ..|| .| . ....                        ......|.. ||||..| |   |
vmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk........................kkkkeerevfqyhfksWPdhgvp

ECSTGLLRFMYRLREL-PQF---NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAE---DKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
.    .| |.  ...   ..   .. |.|.|||||.||||||| || .|..   .    . .| ..|  .|.||. .||  .|| |.|||....
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
0046845 (Phosphotyrosine protein) phosphatases II 1169-1441 9.1e-67 220.7 In-house 1-276 (284) alignment 
Range on Protein: 1169-1441
Range on HMM: 1-276/284.0
GLEEEFKKLERNLTTPL-SSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGH-ADSSYINASHIKGY-------FFDYIAAQDPVSEgTAFDFWRMIAD
||||||..| .. ...| | ..|.. ||| ||||   .|.|. ||.| .. |.  ||.|||||...||          .||.| |... |  |||||. .
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.tvedFwrmvwe

QNVTTVVMLSDETDWS--DVEKYWPIDgsGTECHFgserNSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpANQEVVQYSYTGWPsDSIVPKSANSLMNL
|||...||| .... .    ..||| .  |.  ..    . . ||..|||...|...|.|. .... ..     .| .. ||.|| |  || |...|...
qnvrvIVmltelvengrekcaqYwple..gevlty....gdftvtllseevkddytvrtleltnlgytg..esrtvthfhytswp.dhgvppspedllef

IEMVLQRQSSlMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQ---RIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
...| . ... .... ||||||..| . .| ||.. ||. . ..|.   ..||...|| | ..||.|.. .||| |.|.||..|...
lrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
DSPc_SM00195 1170-1439 1.9e-66 219.5 In-house 2-262 (263) alignment 
Range on Protein: 1170-1439
Range on HMM: 2-262/263.0
LEEEFKKLERNLTTPlSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKG--YFFDYIAAQDPVsEGTAFDFWRMIADQNVTTVVM
|.|||.|||.. ..  ... |.|..|  ||||.  .|.|. ||.|... .. .|.||||..|||  .  .|||.| |  . |  |||||. ...|...||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivm

LSDETD--WSDVEKYWPIDGsGTECHFGsernSVNVTCVSEEHHQ-DFIIRNLSYSMKDNesmPANQEVVQYSYTGWPSDsIVPKSANSLMNLIEMVLQR
|..| .     ...||| .  |..  ||    ...|..|..|... ..|.|.|.......     ...| || |..||    ||.|..|...|...| ..
lteeeengkekcdrywpees.ggketfg....kisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkks

QSSLmgsQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
.|.    ..|||||| .| . .|.|..|.... . ..|...|.|..|| | ..||.|.. .|||.|.|.|...||
ksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1170-1439 1.9e-66 219.5 In-house 2-262 (263) alignment 
Range on Protein: 1170-1439
Range on HMM: 2-262/263.0
LEEEFKKLERNLTTPlSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKG--YFFDYIAAQDPVsEGTAFDFWRMIADQNVTTVVM
|.|||.|||.. ..  ... |.|..|  ||||.  .|.|. ||.|... .. .|.||||..|||  .  .|||.| |  . |  |||||. ...|...||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivm

LSDETD--WSDVEKYWPIDGsGTECHFGsernSVNVTCVSEEHHQ-DFIIRNLSYSMKDNesmPANQEVVQYSYTGWPSDsIVPKSANSLMNLIEMVLQR
|..| .     ...||| .  |..  ||    ...|..|..|... ..|.|.|.......     ...| || |..||    ||.|..|...|...| ..
lteeeengkekcdrywpees.ggketfg....kisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkks

QSSLmgsQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
.|.    ..|||||| .| . .|.|..|.... . ..|...|.|..|| | ..||.|.. .|||.|.|.|...||
ksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0037934 (Phosphotyrosine protein) phosphatases II 844-1107 3.9e-66 218.4 In-house 4-241 (243) alignment 
Range on Protein: 844-1107
Range on HMM: 4-241/243.0
ASNRKENAIKNRYNDIRAFDDTRVKLkkingDDySDYINANFIKSWKeKklFIAAQAPVDATIGD----FWRMVWEQESYLIVMVANLTEKNRQQCAKYW
 ....||  |||| || ..|..||||     .. |||||||.|. .. .  .|| |.| . |. |    ||||.||. .  |||. .|.|..|..||.||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PDEQitRYGDIIVEPASFSFHSDYAIRAFDIAhigecgpdvipngngveyanvpivKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLREL---
|.|.  .|||..|.  |.. ..|| .| . .                           .  . .| . .||...| |...|.  . ||.|.  .||    
pgev..tygdftvtllseehlddytvrtllle........................nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefiee

-----PQFNNSPVVIHCSAGVGRTGTFISIDSMLDQClaedKANIFEFVCNLRRQRNL-MVQSLEQYVFIYKALAEW
        ...||..|||||||||||.| .. ||...    . ...| |. ||.||.  .||...||.|.|.||.|.
llsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 1149-1441 9e-66 217.7 In-house 13-291 (297) alignment 
Range on Protein: 1149-1441
Range on HMM: 13-291/297.0
SPRVAIVSSRESMTTSNGETGLEEEFKKLERNLTtPlsSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGH-ADSSYINASHIKGYFF---DYIAAQDP
. .. ..     ... |. |.|..||..| ..   .    .|.. ||  ||||   .|.|  ||.| |  |.  ||.|||||...|| .   ..||.| |
piplsvldlllllekansktllllefeellslkp.d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

vSEGTAFDFWRMIADQNVTTVVMLSDETDWSD-VEKYWPIDGSgtechfgsERNSVNVTCVSEEHHQDFIIRNLSYSMkDNESmpanQEVVQYSYTGWPs
 ...|  |||||. .|.||..||| .... .   ..||| .|.        . . . ||....||......|.|. .. ..||     .| .. ||||| 
.lpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg........tygdftvtllkvehldgytvrtlevtn.nges....rtvthfqytgwp.

DSIVPKSANSLMNLIEMVLQRQSSLmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
|  || |...|....|.| .....| ... |..||| .| . .| ||.. |.. . . |...||...|| |...||.... ..|| |.|.||......
dhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0036941 (Phosphotyrosine protein) phosphatases II 1163-1442 3.1e-65 215.7 In-house 8-280 (297) alignment 
Range on Protein: 1163-1442
Range on HMM: 8-280/297.0
TSNGETGLEEEFKKLERNLTtPLSSNFAAKDENLLKNRYEAAVPFDKYRVILpptiGHADSSYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMIADQ
 ... ..|..||..| ..|  . | . |.. ||| ||||   .|.|. ||.|    .. .|.|||||...||   . .||.| | .. |  |||||. .|
kllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpn.tvedFWrmvweq

NVTTVVMLSDETDWSD--VEKYWPIDGSGTECHfgserNSVNVTCVSEEH--HQDFIIRNLSYSMKDNEsmpANQEVVQYSYTGWPsDSIVPKSANSLMN
|||..|||......     ..||| .  .. ..     . . ||..|.|.  ..|...|.|  ....|.      .| .. ||||| |  || |..||..
nvtvIvmltelvelgrekcaqywpleegeslty.....gdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwp.dhgvpespaslld

LIEMVLQRQSSLmGSQAPIVVHCRNGSSESGIFICISLLWLRQK---AEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKT
.||.|..... |  |. |..|||..| . || ||.. |.. . .    |...|....|| | ..||.... .||| |.|.||.... |.
fielvrkvlkll.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 829-1107 3.2e-65 215.0 In-house 8-267 (274) alignment 
Range on Protein: 829-1107
Range on HMM: 8-267/274.0
AQEYESLPHFQlDTVASNRKENAIKNRYNDIRAFDDTRVKLKKING-DDYSDYINANFIKSWK-EKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVAN
 .|. .||    |.   .   .. ||||..|   . .|| |.. .. |. |.|||||.||  . |.| ..|.| |.  |. |||||....|. .|||...
ekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LTEKNRQQCAKYWPDEQIT----RYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPdvipngngveyanvpivkgqfannsrrILQYHFTNWNDYKAPEC
|.|.|.|.||.|.||.. .    ||||. ..  .   . || .| . . .  ..                             .  | .|.| | |.|. 
lkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...........................vkhywytdWPdhksPdd

STGLLRFMYRLRELPQFNN---SPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
 . ||...   .|  . .|   .|||.|||||.|||| ||.|.  . |  .| . .... ||||| .|  |||. ||| .|..||...
antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
0040438 (Phosphotyrosine protein) phosphatases II 1165-1441 1.8e-64 213.3 In-house 15-278 (317) alignment 
Range on Protein: 1165-1441
Range on HMM: 15-278/317.0
NGETGLEEEFKKLERNLTTplSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGY--FFDYIAAQDPVsEGTAFDFWRMIADQNV
.. |.|.|||..| ..     . ..|.. ||  ||||   .|.|  ||.| |. |. ||.|||||...|.     .||.| |  ..| .|||||. .|.|
sdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.pntvedFwrmvweqgv

TTVVMLSDETDWSD--VEKYWPIdgsGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNEsmpANQEVVQYSYTGWPsDSIVPKSANSLMNLIEM
|..||| .... ..   ..|||    |.. ..|     . ||..|||.......|.|  . ....      .| .. ||||| |  ||.| ..| ...|.
tvivmLteleelgrekcaqYwpl...getltygd....ftvtllseeelagitlrtlevedlgds...esrtvthfhytgWp.dhgvppspdllldflea

VLQRQSslmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
| . ..   ... |..||| .| . .| ||.. |.. . . |...||...|| |...||.... .||| |.|.||..|. .
vreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0043336 (Phosphotyrosine protein) phosphatases II 1164-1439 5.1e-64 211.7 In-house 16-277 (278) alignment 
Range on Protein: 1164-1439
Range on HMM: 16-277/278.0
SNGETGLEEEFKKLERNLTtpLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGY--FFDYIAAQDPVSEgTAFDFWRMIADQN
 |. |.|..||..| .. .   . ..|.. ||  ||||   .|.|  ||.| .. |. ||.|||||...||    ..||.| | .| |  |||||. ...
lnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.tvedFwrmvwelg

VTTVVMLSDETDWSD--VEKYWPidgsGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSM-KDNESmpanQEVVQYSYTGWPsDSIVPKSANSLMNLI
|||.||| ......     .|||    |.   .|     . ||...|||..|...|.|  .. .|.||    ..|..| |.||| |  || | ..|....
vttivmLtelvelgrvkcaqYwp....ggsltygd....ftvtllkeehlddytvrtlevtnlgdges....rtvthyhylgwp.dhgvpeslsllldfl

EMVLQRQSslmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
..|.....    |. |..|||..| . .| ||.. ||. . . |...|....|| |...||.... ..|| |.|.||..|.
kavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1163-1440 3.3e-63 208.7 In-house 15-281 (318) alignment 
Range on Protein: 1163-1440
Range on HMM: 15-281/318.0
TSNGETGLEEEFKKLERNLTTPLSSNFaAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQ
 ..||. |.||...|.|.  |. | .   .. |  ||||   ...|. || | .. |. .| ||||..| ||     ||||| |..| |  |||||. .|
resGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpe.tieDfWrmvWeq

NVTTVVMLSDETDW--SDVEKYWPIDGSGTechFgserNSVNVTCVSEEHHQDFIIRNLSYSMkdnESMPANQEVVQYSYTGWPsDSIVPKSANSLMNLI
| ...|||..|..     |..||| .|| .   .    ... |.  .| . .|...|... .    . . ....| || || || |. ||.|. ||..|.
nsavivmltqeeergkakvhryWPskgsrs...y....gklvvelkeevelsdyvlrefkvtr...teeeesrqvrqyhytsWp.degvpesgaslldlv

EMVLQRQSslMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
  | . |     .. ||||||  |    |.|| .. |  | |||. .||||||| |...|..|    .|| |.| .| ... 
rqvskaqq..ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
0045450 (Phosphotyrosine protein) phosphatases II 1161-1439 2.8e-62 206.5 In-house 20-304 (307) alignment 
Range on Protein: 1161-1439
Range on HMM: 20-304/307.0
MTTSNGETGLEEEFKKLERNLTT-PLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGH-ADSSYINASHI--------KGYFF--DYIAAQDPVSEg
... .. |||..||.|| .  .. . . ..|.. ||  ||||   .|.|  ||.| .. |.  ||.|||||..        .|| .   .||.| | .| 
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.

TAFDFWRMIADQNVTTVVMLSDETDWSD--VEKYWPIDgsGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKdnESMPANQEVVQYSYTGWPSDSi
|  |||||. .|.||..|||.....  .    .||| .  |.|  .|     . ||..||||......|.|  ...  .      .| .. ||||| .. 
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde..geeltygn....ftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgwpdhg.

VPKSANSLMNLIEMVLQRQSSLmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQR---IDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
||.| ..| ..||.|.. ...| ... |..|||. | . .| ||.. |.. . ..|.    .|....|| |...|| ... .||| |.|.||....
vppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 1195-1436 4.9e-60 198.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 1195-1436
Range on HMM: 1-234/235.0
NLLKNRYEAAVPFDKYRVILPPTIGHADssYINASHIKGYF--FDYIAAQDPVSeGTAFDFWRMIADQNVTTVVMLSDETDW--SDVEKYWPiDGSGTEC
|. ||||.  .|.|| || |  . |. |  ||||...|||   . .||.| |..  |  |||||. ...|...||| ....     ...||| . .....
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwp.eeeeesl

HFGSernsVNVTCV-SEE-HHQDFIIRNLSYSMKDNESmpANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQsslMGSQAPIVVHCRNGSSESGI
..|.    ..|... .|. .......|.|... |..||  ...|| |. ||.|| |. ||.|..||..||..| ...     ...|.|||| .|.. .|.
tygd....ikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgt

FICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALA
|.....|. . .||. .||.|.|| |...||.|....||| |.|.|..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1195-1436 4.9e-60 198.2 In-house 1-234 (235) alignment 
Range on Protein: 1195-1436
Range on HMM: 1-234/235.0
NLLKNRYEAAVPFDKYRVILPPTIGHADssYINASHIKGYF--FDYIAAQDPVSeGTAFDFWRMIADQNVTTVVMLSDETDW--SDVEKYWPiDGSGTEC
|. ||||.  .|.|| || |  . |. |  ||||...|||   . .||.| |..  |  |||||. ...|...||| ....     ...||| . .....
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwp.eeeeesl

HFGSernsVNVTCV-SEE-HHQDFIIRNLSYSMKDNESmpANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQsslMGSQAPIVVHCRNGSSESGI
..|.    ..|... .|. .......|.|... |..||  ...|| |. ||.|| |. ||.|..||..||..| ...     ...|.|||| .|.. .|.
tygd....ikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgt

FICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALA
|.....|. . .||. .||.|.|| |...||.|....||| |.|.|..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_CG7180_pd Subfamily CG7180 817-1111 2.2e-59 195.5 In-house 8-293 (296) alignment 
Range on Protein: 817-1111
Range on HMM: 8-293/296.0
YVVRHRDTDFLFAQEYESLPHFQLDTVAS-NRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWE
.| ..|.   .. .|..  |... .. |   ||||  |||. ..  .| .|| |.|..|.. |||||| .. |.  || .|  .||.. |...|||.|..
lvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvyd

QESYLIVMVANLTEKNRqQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIgecgpdvipngngveYANVPIVKGQFANNSRRILQYHFTNWN
.|.  .|.... .. .. .. .||| .. ..||.|.||  .    ..  || | . .                   .   . |   . | ......| |.
eeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkk...............ivalteqekqvkaetRivklfqlteWe

D-YKAPECSTGLLRFMYRLRELPQFN-----NSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHM
   | |  ...|. .. | | . . .     ..|||...| |..|.| ...||  |..   |.. ..||.|  |||.|. .|.. |.| .||  | |. .
ledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

YG
 .
cn
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1157-1440 2.5e-59 195.9 In-house 12-284 (319) alignment 
Range on Protein: 1157-1440
Range on HMM: 12-284/319.0
SRESMTTSNGETGLEEEFKKLERNLTTplSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF--FDYIAAQDPVSEgTAFDFW
.|  .  |.|||.||.|||.|.   ..  . . | |.||  ||||.  ...|. ||.|..  |  .| |||||.| ||     .||.| |... |  |||
erlkalastgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen.tiedfW

RMIADQNVTTVVMLSDETDWSDV--EKYWPidgSGTECHFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNEsMPAnQEVVQYSYTGWPSDSiVPKSAN
||. .... .||||.. ..  .|  .||||   . .  ..|     . ||  .||. .|.|||.|.   | .| . .  ||... || || .  ||..| 
rmvWeeessivvmltklveklkvklkkywp...eenfeeyG....rlivtleeeeeledyiirklklnkksse.vet.RevkhfqyteWpdhd.vPekat

SLMNLIEMVlqRQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
||..|.. .  |.|    .. |||||| .|.   | || ..    | | |. .|||.||. |   |..|  | |||.|.| || ....
slldllkri..rksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1155-1439 3.4e-59 195.5 In-house 14-290 (298) alignment 
Range on Protein: 1155-1439
Range on HMM: 14-290/298.0
VSSRESMTTSNGETGLEEEFKKLERNLT--TPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF--FDYIAAQDPVSEgTA
.. ..... ... ||...||..|..        ... | |.||  ||||   ...|. ||.|  . .  .| |||||....|     .||.| |. | | 
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte.tv

FDFWRMIADQNVTTVVMLSD--ETDWSDVEKYWPIDGSGTechFgserNSVNVTCVSEEHHQDFIIRNLSYSMKDNEsmpANQEVVQYSYTGWPsDSIVP
 |||||. .....|.||| .  |.|  ...|||| .|. |   .    ....|.  |.|.. |.|.|.|  | |..|    ..||.| ..| || |  ||
edFWrmvteedigtiVmltnleeldktkyhkywPdegket...y....geitvsllskeefadlivrklkvskkkee...kerevrqlhftsWp.dkgvp

KSANSLMNLIEMVLQrqSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
. |.|...|.. | .  |     ..|..|.| .|   || || |. .  | |.|| .||||.|| |  .|| . .  |||.|.| |  ...
enatsvldllrkvra..sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 808-1105 1.9e-58 192.7 In-house 2-280 (290) alignment 
Range on Protein: 808-1105
Range on HMM: 2-280/290.0
IPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLDT--VASNRKENAIKNRYNDIRAFDDTRVKLKKINGD-D-YSDYINANFIKSWKEKKLFIAAQAPVD
||||..    .  |   .  | .....|  .. .      . ..|  .||...|   || |. |..|.|. |   .|||| .|| .|||| .||.|.|| 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPasfsfhsdyairafdiahigecgpdvIPNGN--GVEYANVPIVKGQFAN
 |. |||...|....  |||. | .|.....| .||||.. ..|| . ..                           . . .  .    .. . . . |.
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl..........................lneetlneyierklevknknsag

NSRRILQYHFTNWNDYK-APECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFI
... . ||..|||..    .. .| || .  . .   .  | ..|.|||..|||...|....  ...|  |   ..|. . ..| |.  .||. .|| .|
akqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgi

YKALA
.. . 
fqivl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 808-1136 2.3e-58 192.5 In-house 4-264 (392) alignment 
Range on Protein: 808-1136
Range on HMM: 4-264/392.0
IPVDDLPTeYVVRHRDTDfLFAQEYESLPHFQLDTVASNRKE-NAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATI
||| ..|. .| . | .  ||..|.  ||  ..   .. .|| |  ||||..|  .| .||||. |.    |||.|| .|.| . .| .||.|.|  |..
ipvaqfpa.fveknrhsa.lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

GDFWRMVWEQESYLIVMVANLTEKNrqqcakywpdeqitrygdiivepasfsfhsdyairafdiahigecgpdvipngngveyanvpivkgqFANNSRRI
 ||||||....   |.||..| | .                                                                     .. | .
ddfwrmvfqenvttiamvtklkegd...................................................................kgddartv

LQYHFTNWNDYKAPECSTGLLRFMYRLRE-LPQFnNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALA
 |.|||.| |   |. .. ||.|.  ..    |.   |..|||||||||||  |||||.. ..      ..|.|| |.||.|  |||. ||| ||| |. 
aqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl

EWHMYGDTDEDVRDFEDHYQRLCASNRDRAV
|  .. .|   |  | || | | .|   .. 
edllwrntlipvvhftdhlqdlstssdGdvr
0040439 (Phosphotyrosine protein) phosphatases II 1189-1439 1.2e-57 190.7 In-house 5-246 (249) alignment 
Range on Protein: 1189-1439
Range on HMM: 5-246/249.0
FAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGY--FFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDET--DWSDVEKYWPId
.| . ||. ||||   .|.|  ||.| .. |. .|.|||||.|.||    ..||.| | .| |  |||||. ....|..|||....  .. . ..|||  
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

gsG--TEChfgserNSVNVTCVSEEHHQDFIIRNLSYSMKdneSMPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQSSLmGSQAPIVVHCRNG
  |  .|.      . . ||..|.|...|...|.|  ...     .   .| .. ||.|| |  ||.| ..|...||.|.. ...| ... |..||| .|
..ggsley......gdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleel.pkggpvlVHCsaG

SSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
 . .|.||.. |.. . . |...|....|| |.|.||.... .||| |.|.||....
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1163-1442 2.2e-57 189.5 In-house 17-286 (305) alignment 
Range on Protein: 1163-1442
Range on HMM: 17-286/305.0
TSNGETGLEEEFKKLERNlTTplSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQ
... ..|||...|.| ..  .  | .   |..|  |||... ...|. |.|| ..  . || |||||...||     ||.|| |. . |  ||||.| . 
rvysdkgleaqykslyee.ee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn.tvadfWrlivee

NVTTVVMLS--DETDWSDVEKYWPiDGSGTECHFgserNSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpANQEVVQYSYTGWPSDSiVPKSANSLMNLI
 |.|.|||.   | . .  ..||| .  . . .|    ....|.  ||.. .|.|.|.|. |..|...   .. |.||  | || .  ||..| ||..||
kvstivmltklveggkdkCrqYWp.esktekkef....gefsvelksektasdyieRklkisiededk..esrtvlqyqltdWPdhG.vpqfatsllsli

EMVLQRQSSlmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKT
. | ..|..  . . |..||| .| . .|.||....   | |.|. .|||. .| | |.|. | .  .|| |.. ||...|  .
krvqkdqkk..dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1165-1437 8e-57 187.9 In-house 31-289 (319) alignment 
Range on Protein: 1165-1437
Range on HMM: 31-289/319.0
NGETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNV
.  | || ||... .  .     .||  |.|  |||.   ..||| .| | ..||   | |||||...||     ||||| |  . |  |||||| ..|.
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldn.tladfWrmiweync

TTVVMLSdetdWSDVEKYWPIDGSGTEchfgsERNSVNVTCVSEEHHqdFIIRNLSYSMKDneSMPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVL
.|.|.|.         .||| ..  .|     ||  |.|. | | .   ...|..  | .    .   ... |. . ||| |  ||...  || |.. | 
stivllt....kdkcsqywplkivike.....erfkvkvdsveetae..yvvrdielsedg..kekdirkitqfhflGwp.dvGvpdypsdlmrlvkkvr

QRqSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALAD
    | .  .|.|||||  |.  .|..| .  |  | | |...||...|..|.  |. .   . || |.| || .
hl.tskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0042113 (Phosphotyrosine protein) phosphatases II 1189-1440 1.3e-56 187.1 In-house 3-244 (245) alignment 
Range on Protein: 1189-1440
Range on HMM: 3-244/245.0
FAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGY--FFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETDW--SDVEKYWPId
.|.. ||  ||||.  .|.|  ||.|.|. |. ||.|||||...||     .||.| | .| |  |||||. ....||.|||..|..    . ..|||  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

gsGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKdneSMPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQSSlmGSQAPIVVHCRNGSS
  |..  .|     . ||..||||..|...|.|. ...     .  .||..| |..|| |  || . ..| ...|.|.. ...  .|. |..|||. | .
..gesltygd....ftvtllseehlddytvrtlevtnl...gddesrevihyhylpwp.dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvg

ESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
 .| ||.. |.. . ..|........|| |.|.||.... ..|| |.|.||.....
RtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPRG_pd Subfamily PTPRG 1163-1440 2e-56 186.4 In-house 14-288 (563) alignment 
Range on Protein: 1163-1440
Range on HMM: 14-288/563.0
TSNGETGLEEEFKKLERNLTTP-LSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADS-SYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMIA
 ..|..|..|||..|... ..  |  ... | ||  ||||   |..|. || | |. |. ..  ||||..|.||    ..||.| |. . |. |||||| 
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkd.tfddFWrmiW

DQNVTTVVMLSD--ETDWSDVEKYWPIDGSGTECHFGSERNSVNVTCVSEEHhqDFIIRNLSysMKDNESMPANQEVVQYSYTGWPsDSIVPKSAnsLMN
.|||...||...  |    . . ||| |.| |  ..     . .|.... ..   ..|.||   .|.....  ...| || || || |  ||...  |..
eqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr..tlviknlk..lkkkkqcdteklvrqyhytkWP.dhgvPehs..lpv

LIeMVLQRQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
|| .| ... . .    ||||||..| ...|..| .. |  . ..|. ..||...| ....|.....  ||| | . || . |.
Li.fvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_PTPN1_pd Subfamily PTPN1 839-1107 4.9e-56 184.6 In-house 21-270 (290) alignment 
Range on Protein: 839-1107
Range on HMM: 21-270/290.0
QLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGddysDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKY
...| .....||  .||| |.. .| .|.||.. .     |||||....  . |. .| .| |.  |.. ||.|||||.|  .||. .. ||....||.|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WP-DEQ--ITRY--GDIIVEPASFSFHSDYAIRAFDIAHigecgpdvipngngveyanvpivkgQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRL
|| .|.     .    . |.  |   .| | .| ...                           . ....| ||..|.| |.|.  ||. . .|.|....
wPqgeeekellledtklkvkliseerksyytvrllelen.........................lktqetreilhfhyttwpdfgvpespaaflkflfkv

RELPQFN--NSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDK---ANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
||   ..    |.|||||||.||.|||. .|..| .  ..|.    .| . ...||..|  ..|  .|  | | |. | 
resGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1173-1437 4e-55 182.3 In-house 3-253 (284) alignment 
Range on Protein: 1173-1437
Range on HMM: 3-253/284.0
EFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSd
||... .  .     .||  |.|  |||.   ..||| .| | ..||   | |||||.|.||     |||.| |  . |  |||||| ..|..|.|.|. 
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldn.tladfWrmiweyncstivllt.

etdWSDVEKYWPIDGSGTEchfgsERNSVNVTCVSEEHHqdFIIRNLSYSMKDNesMPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRqSSLMG
        .||| ..  .|     ||  |.|. |.| .   ...|..  | . .  .   ... |. . ||| |  ||...  || |.. |    .| . 
...kdkcsqywplkivike.....erfkvkvdsveesee..yvvrdielsedgk..ekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhl.tsken

SQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALAD
 .|.|||||  |.  .|..|..  |  | | |...||...|..|.  |. .   . || |.| || .
hranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1169-1436 7.7e-54 177.7 In-house 25-276 (315) alignment 
Range on Protein: 1169-1436
Range on HMM: 25-276/315.0
GLEEEFKKLERNLTTPLssNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNVTTVV
|...... .      ||  . | | ||  ||||   ...|| || || .  . .| |.||. |.||     ||||| |  . .  ||||.. .......|
gfkqdyesipggqlhpl..dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva.svkdfwrlvfeedigkiv

MLSD--ETDWSDVEKYWPIDgsgtECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNesmpaNQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQR
||..  | . . .||||| .    .  .|     . || .|||..... .| ||  ..||      .||||. || || |. |||.. .|||||  | | 
mltnlvegekrkaekywpdk....kviyGk....itvtrkseevnteytvrtlsvvfgdn.....irevvqlhytswp.dmgvpkytiplmnlirtvkqh

QSSLMgsqAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALA
. . .   ..|||||..|   .| ||... .  . .||. |||.. ..|... |  |    ||| | | || 
htnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
0045098 (Phosphotyrosine protein) phosphatases II 1184-1440 1.1e-53 177.8 In-house 22-273 (278) alignment 
Range on Protein: 1184-1440
Range on HMM: 22-273/278.0
PLSSNFAAKDENLLKNRYEAAVPFDKYRVIlpptighadsSYINASHIKGYFFDYIAAQDPVSeGTAFDFWRMIADQNVTTVVMLSDETDWS--DVEKYW
| . ..| . .|| ||||   .|.|  ||.           |||||.|.|| . .||.| |    |. |||||. ....|..||| ......    ..||
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgypkkfIatqgPlp.stvadfwrmlwelgitvivmltelvelgrekcaqyw

PiDgSGTECHfgserNSVNVTCVSEEHHQDFIIRNLSYSMK-DNESMPANQEVVQYSYTGWPsDSIVPKSA--NSLMNLIEMVLQRQS----------SL
| . .|.. .     . . ||..|||...|...| | .     ...   . .| .. |..|| |  || .   .|. .|.|.......          .|
p.e.ggslty.....gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwp.dhgvpslpilksflellefirealkllaslllsslll

MGSQAPIVVHCRNGSSESGIFICISLLWLRQkaEQRIDVFQTVKGLQSHRPM-MFTRFEQYSFCYRALADYIS
..|. |..|||. | . .| .... |.  .   |...|....|| |.|.||. ... .||| |.|..|.....
ldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 849-1105 1.4e-53 176.5 In-house 2-236 (237) alignment 
Range on Protein: 849-1105
Range on HMM: 2-236/237.0
ENAIKNRYNDIRAFDDTRVKLKKINGDdySDYINANFIKSWKE-KKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPD-EQITR
|| ||||| .|.|.| .|| ||   ..  ||||||...|..    | .|||| |....  |||.|||..   .|||.. | |.|...| ||||. .| . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDIIVEPASFSFHSDYAIRAFDIAHIGECGpdvipngngveyanvpivkgqfanNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF--NNSPV
|| . |        |||..|.. ... ..                          . | | ||.|| | |   |. .. ||||  .. . ..   . .| 
ygvltvslkkkeefsdytvrslllskrltlk........................evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpw

VIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALA
.||||||||||| |. ||.|| |.  .   .|...| ..  .|  ..|. .|||||.... 
iihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPRA_pd Subfamily PTPRA 1170-1438 1.7e-53 176.7 In-house 34-294 (330) alignment 
Range on Protein: 1170-1438
Range on HMM: 34-294/330.0
LEEEFKKLERNLTtPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNVTTVVM
. |||. |        . . |.|.||  |||.   .|.|  ||||..  |. .| |||||.|.||     .|||| | .| |  |||||| .|. .|.||
freefnalPagpi.qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee.tvedfwrmiweqksativm

LSD--ETDWSDVEKYWPIDGSGTechFGSERNSVNVTCVSEehhqDFIIRNLSYS-MKDNESMPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQR
|..  | . .  ..||| .|. |   .|  | .|. . |..    |. .|..    . |.    ... | |. .|.|| |  ||  .  ...|.. | . 
ltelkerkeekcaqywPdeGlvt...yGnirvevedetvlv....dytvrkflvqqlpdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkkl

QSSlMGSqaPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADY
.   ...  ||||||  |   .| || .. .  | |||...|||..|| |.  || |    ||| |.|..| .|
nqq.sag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1188-1439 1.7e-53 176.4 In-house 2-242 (250) alignment 
Range on Protein: 1188-1439
Range on HMM: 2-242/250.0
NFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSD--ETDWSdVEKYWPI
. | | .|. ||||   ...|. ||.| .. |  .| |||||...||     .||.| |... |  |||||. .....|.|||..  |..   ...|||.
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqa.tiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

DGSGTechFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpaNQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQSSlmGSQAPIVVHCRNGS
... .   .|    .| |.  |.|.. |...|.|  | . ...   .. |.|.... || |  ||. |.. ..|.. | . |      .||..|.| .| 
ekaek...yG....dvtvsllskeefadytkrklklskakkad...erivrqlhfvvWP.dkgvPevatavLellkkvqasqqq..agnaPvivqCsaGv

SESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
. || || |. .  | | |. .|||. .| |. .|| . .  |||.|.|...  ..
grsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
0037934 (Phosphotyrosine protein) phosphatases II 1188-1439 7.6e-53 174.9 In-house 3-242 (243) alignment 
Range on Protein: 1188-1439
Range on HMM: 3-242/243.0
NFAAKDENLLKNRYEAAVPFDKYRVILpptighADSSYINASHIKGYFfDYIAAQDPVSEgTAFD----FWRMIADQNVTTVVMLSDET--DWSDVEKYW
..| . ||| ||||   .|.|  ||.|       .|.||||..|...   .|| | | .| | .|    ||||. ....|..||| ...  .. ....||
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp.rliatqgPlpe.tveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PidgsGTEcHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNESMPanQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQSS-----LMGSQAPIV
|    |.. ..|     . ||..||||..|...|.|.....| .  .  ..|..| |..|| |  || | ..|......| . ...        |. |..
p....gev.tygd....ftvtllseehlddytvrtlllenldlddlt..rlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvl

VHCRNGSSESGIFICISLLWLRQkaeqRIDVFQTVKGLQSHRPM-MFTRFEQYSFCYRALADYI
|||. | . .| .|.. |. |.     ..|....|| |...||. ... ..|| |.|.||. ..
VHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 816-1107 8.6e-53 174.0 In-house 8-292 (301) alignment 
Range on Protein: 816-1107
Range on HMM: 8-292/301.0
EYVVRHRDTdflFAQEYESLPHFQLD-TVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDD--YSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRM
. .. | ..   |...|..| . . . .. . ..||.  ||...|  .|| |. ||. .  |    .||||..|.. .||| |||||.|.. |. ||||.
hvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrl

VWEQESYLIVMVANLTEKNRQQCAKYWPDE--QITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGpdvipNGNGVEYANVPIVKgqfanNSRRILQYH
.|..    ||||.|| |. ...| .|||.   . ...| . |.  .   . |. || . .      .     ||      .|   |     .|. .||..
iwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsn.....ngyierkfkvksdk.....sswdvlqlq

FTNWNDYKA-PECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
 |.| .    .|  | |      .    . . .|||.|||..|.|.|...|..  |.|| ||   ..|. .  .||..  .|. ||||..||... ..
vtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 827-1114 1e-52 173.8 In-house 10-272 (283) alignment 
Range on Protein: 827-1114
Range on HMM: 10-272/283.0
LFAQEYESLPHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGddysDYINANFIK---SWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVM
|| . .. |   .||.. .  .||  |||...| . |  ||.||  .     ||||| ||    | |..| .|.||.|.| |. |||.||....   |||
lfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

VANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIgecgpdvipngngveyanvpivkgQFANNSRRILQYHFTNWNDYKAPECS
...| | .|..|..||| .    ||.  |       .  . |. . . .                           |...  .  | . .| .|      
ltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn........................ssakstlllahyqvidWleygeqaii

TGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYGDTD
  |..|        . ...|.|.|||.|.|||..||.. . ... |.|   ..|. | ..| ||  .||.|.|| .....  |  . |||.
nslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 808-974 6.6e-52 171.5 In-house 2-170 (318) alignment 
Range on Protein: 808-974
Range on HMM: 2-170/318.0
IPVDDLPTEYVVRHRDTDFLFAQEYESL-P-HFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDAT
|.|.|| .     ... . |. .||| | . . .  .. |. . |. ||||..| |.|.|||||....|.  |||||||.|  ...|| .||||||.  |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

IGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIG
| |||||||||.| .|||.....|. ......|||... . ||.. ||  .    ||| .| | . . .
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrte
subfamily_PTPN6_pd Subfamily PTPN6 1160-1441 1.3e-51 170.4 In-house 18-299 (306) alignment 
Range on Protein: 1160-1441
Range on HMM: 18-299/306.0
SMTTSNGETGLEEEFKKLERN-LTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPpTIGHADSSYINASHIKG----YFFDYIAAQDPVsEGTAFDFW
  ..| . .|.||||..|...  .. || . .|| ||  ||||.. .|||. ||||    . ..| ||||. ||.        |||.|  . | |  |||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcl.ettvsdFW

RMIADQNVTTVVMLSDETDW--SDVEKYWPIDGSGTEchFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpANQEVVQYSYTGWPsDSIVPKSAN
||. ..| . .||.  |..   .   .|||   . .|  .|    ...||.|||....|.|.|.|| | |....   ..||.|| .. || |  |||. .
rmvwqensrvivmttkevErgkekCarYWPdeeekee..yG....kisvtnvseksladYilRelsvskkkkkk..eerevfqyhfksWP.dhgvpkdpg

SLMNLIEMVLQRQSSLM-GSQAPIVVHCRNGSSESGIFICISLLW---LRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
 .....| | ..|..|.  .. |||||| .|    | || | .|     ... .  ||. ..|| ....|  .    .|| | |.|.. || .
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1162-1439 2e-51 169.8 In-house 15-279 (288) alignment 
Range on Protein: 1162-1439
Range on HMM: 15-279/288.0
TTSNGETGLEEEFKKLeRNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMIAD
.  ...||..||...|  .|    |.. . . .|  ||||.  .|.|  || |      |.. |||||.|.|.     |||.| |. . |  |||... .
ksarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPlad.tvndfWelvye

QNVTTVVMLSD--ETDWSDVEKYWPIDGsgTECHFGsernSVNVTCVSEEHHQDFIIRNLSYSmkdneSMPANQEVVQYSYTGWPSDSiVPKSANSLMNL
....|.|||..  | . .  |.||| ..  .. ..|    ||.|| |.... .||. |.|            . |. || |..|| .. ||.|.. |..|
nktstivmltelveggktkCeeYWPdad..kpknyG....svtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhg.vPeskapllel

IEMVLQRQSSLmgsQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
...| . ...    . ||.||| .|   .|.|| .  |  . ..|. |||. ||. |  .|...    .|| |.|..|.. |
lrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN12_pd Subfamily PTPN12 1168-1442 2.3e-51 169.4 In-house 8-280 (290) alignment 
Range on Protein: 1168-1442
Range on HMM: 8-280/290.0
TGLEEEFKKLERNL-----TTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMIADQ
  ...||.|| .        .  |.. . |.||  ||||   .|.|| || |  . .. .|.||||..|||      ||||| |... |  |||||| ..
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpk.tlddfWrmiwek

NVTTVVMLSDET--DWSDVEKYWPIDGsGTECHFGsernSVNVTCVSEEHHQ-DFIIRNLSYSMKdnesmPANQEVVQYSYTGWPsDSIVPKSANSLMNL
||. |||.  |   .    |.|||  | ..|..||    ...||. .|.. . ||.|| |   ..      ....| |. || || |  ||.||.||..|
nveivvmaCrevelgkkkCerYWpeeg.eeelefg....efevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWP.DhgvPssaksllel

IEMVLQRQSslmGSQAPIVVHCRNGSSESGIFICISLLWLRQKA---EQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKT
||.| ..|.    ..||.||||  |    |. | | . .   ||   ....|||. |  |. .|. .    |||.. |.|.|....|.
ielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_PTPRK_pd Subfamily PTPRK 1161-1435 1.4e-50 166.9 In-house 16-273 (314) alignment 
Range on Protein: 1161-1435
Range on HMM: 16-273/314.0
MTTSNGeTGLEEEFKKLERNlttplsSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMIA
. ...|  |. ||.. |          . | ||||  |||..  ...|. ||.| .. | ..| ||||. | .|     .|..| |. | |  ||||.. 
lkraeg.ygfkeeyeslfeg......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe.tvkdfWrlvy

DQNVTTVVMLSDETDWS--DVEKYWPIDGSgteChFGsernSVNVTCVSEEHHQDFIIRNLSYSmKDNESMPANQEVVQYSYTGWPSDsIVPKSANSLMN
|.| ...|||.. .. .     |||| |..     .|     ..|..|. | ......| .. . | . .. . .|| |. ..|||.   ||.||..|..
dencasivmltelvevgrvkClkyWPedte...v.yg....dikvelvetellaelvvrifrve.klargqeeirevrqfqflgWpdh.dvPvsatgllk

LIEMVLQRQSSlmgSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRAL
|.  | . |     .. .||||| .|.  .|.|| |. .    . |. .|||..|| |.|... |    ||| |.| ..
lvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRA_pd Subfamily PTPRA 804-975 1.9e-49 163.4 In-house 10-183 (330) alignment 
Range on Protein: 804-975
Range on HMM: 10-183/330.0
TFGAIPVDDLPTEYVVRHRDTDFLFAQEYESLPH--FQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAP
 .  .||..|  |  .|  |   || .|...||    |    .....||  |||. .|  .| .|| | ...| ..|||||| ||. .|||. ||||| |
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

VDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGE
 . |. |||||.|||.|  |||...| |.....||.||||| .  ||.| ||        ||..| | . ....
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpd
subfamily_PTPRB_pd Subfamily PTPRB 1163-1441 2.2e-49 163.1 In-house 20-287 (293) alignment 
Range on Protein: 1163-1441
Range on HMM: 20-287/293.0
TSNGETGLEEEFKKLeRNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQ
... .... ||...| ... .  . ..| . .|  ||||.  .|.|. || | .. ....| ||||..|.||    ..||.| |. | |  |||||. ..
kadsdlrfseeyeel.kavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe.tvddfWrmvwek

NVTTVVMLSD--ETDWSDVEKYWPIDgsGTECHFGsernSVNVTCVSEEHHQDFIIRNLSYSMkdnesMPANQEVVQYSYTGWPsDSIVPKSANSLMNLI
.....||| .  |      |.||| |   ... .|    ...|| |.||. .|..||.|. .        ....| || .| || |  ||.....|....
kssiivmltqlvekgkvkCeeYWPad..eepvlyG....dikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWp.dhgvPektktlldfv

EMVLQRQSSlMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
..| .....   |..||||||  |   .|.||..  |  . . |. .|.| .|  | ..| ..    .|| | .... |...|
rtvreaiek.taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1162-1441 8.9e-49 160.9 In-house 14-285 (290) alignment 
Range on Protein: 1162-1441
Range on HMM: 14-285/290.0
TTSNGETGLEEEFKKLERnLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHAD--SSYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMI
 ...|..| ...||.|.     . . . .   .| |.||..  |. | .|..| |  || |   .||||..||||    .|||.| |||. |. |||..|
ghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn.tlvdFWkli

ADQNVTTVVMLSDETDW--SDVEKYWPIDgsGTEChFGsernSVNVTCVSEEHHQDFIIRNLSysMKDNESMPANQEVVQYSYTGWPSDSIVPKSANSLM
 ...|| .||| ....       .|||    .|.  .|     .... ..||.....|.|.|.  .|...|  |.|.|.||  | |.|.  |.. . .|.
wqekvtiivmltniieegkvkCqqYWpds..dtka.yg....efsikllneetlneyierkle..vknknsagakqsvtqyqitnwdstgkvtnpqtill

NLIEMVL-QRQSSlmgsQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
 . ||.  ||..     . .||||| .. . |..|. .     . | |. ||||| .| . . .| . .  .|| . .. .  |...
vieemyktqrkrg....ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 807-971 5.3e-48 158.7 In-house 4-169 (319) alignment 
Range on Protein: 807-971
Range on HMM: 4-169/319.0
AIPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLD-TVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDAT
 |.|..| ...   .  .. |...|.. | . . | .  ....||  ||||..| |.| |||.|....| . ||||||.|| ...|.. |||.|||.. |
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

IGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIA
| ||||||||.||. .||...|.|| . .. ||||.|....|| .||.. .    .|| || . . 
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkln
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1163-1439 5.3e-48 158.4 In-house 12-276 (515) alignment 
Range on Protein: 1163-1439
Range on HMM: 12-276/515.0
TSNGET-GLEEEFKKLERNLTTPlsSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSeGTAFDFWRMIAD
. |. |  . |||. |      |     | .. |  ||||.  .|.|. ||.|       .| |.|||.|...     |||.| |    .  ||||.. .
nknrhttlfseefhdlpgpniyp..qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnk.asvddfWrlvlq

QNVTTVVMLSD--ETDWSDVEKYWPiDGSGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNesmpaNQEVVQYSYTGWPsDSIVPKSANSLMNL
.||||..|...  | | .   |||| |  |   .|||    ..|  || |   . |.|.|     |.      . | |. .|.|| |  ||| ..||. |
envttiamvtklkegdkikcgkyWP.dkpgdsvkfGs....ikvelvsleactggikrkltvlkgdd.....srtvtqfhfteWP.dkGvpkhtssllkl

IEMVLQRQSSLMgsqAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
|  |   .. .     |...||  |    |..| |     . |  . .|||..|. .. .|| .    |||.| | |. ...
ikevkadhgqyt...hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1184-1440 8.9e-48 157.9 In-house 36-285 (297) alignment 
Range on Protein: 1184-1440
Range on HMM: 36-285/297.0
PLS---SNFAAKDE-NLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETDW-SDVE
| .   ..  |..  |. |.||.  .|.|. ||.|  .  . || |.|||..||.   .|. | |  . |  |||.|. |..|.|.|||.|. .      
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmka.tvadfWamvldeqvstivmlnddnerdkkca

KYWPIDGSGTechFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNEsmpANQEVVQYSYTGWPSDSIVP-KSANSLMNLIEMVLQRQSSLmgSQAPIVV
.||. .|. |   ||.    | |.  | .. . || |.|. .  ..    |.. | || .. ||....   .||.||..||. | .  |.   ...|..|
ryWsdkgvtt...fGd....vsvvllsvsereGfikrelevtkgkak...arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqn..aegPllv

HCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
|| .|    |... |     . | |. .|.|..|| |. .|| .    |||.| | |. ....
hclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPRB_pd Subfamily PTPRB 807-972 1.3e-47 157.3 In-house 6-174 (293) alignment 
Range on Protein: 807-972
Range on HMM: 6-174/293.0
AIPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLD--TVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDA
 | .... . .   ..|.|. |..|||.| ... |  ..|.....|. ||||..| ..| .||||....... |||||||.|.  . .. |||.| |.  
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDE-QITRYGDIIVEPASFSFHSDYAIRAFDIAH
|. ||||||||..|  |||. .| || ...| .|||.. . . |||| |.  . .  .|..|| . | .
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1162-1442 2.7e-47 156.2 In-house 9-279 (281) alignment 
Range on Protein: 1162-1442
Range on HMM: 9-279/281.0
TTSNGETGLEEEFKKLERnLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMIAD
...| ..|. ||..||.  . .  ... . .||| |||||   | .|. || . |.  . .. ||||....||    .|||.| || . .  .||.|. .
lsqndnaGfieeyeklaa.igvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPa.slvafWqmvwe

QNVTTVVMLSDETDWSDV--EKYWPiDGSGtechfGSERNSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpanQEVVQYSYTGWPsDSIVPKSANSLMNL
|.|...||.  | . . .   .||| |..        .   | |. ..||... .| |... .....|.    .||.|  || || |  ||.... |.. 
qkvsaivmvtreieagklkChrYWP.ddns.....elkygdvtvkstaeeekatyierkfkleresget....reveqlaytaWP.dhGvPattkellef

IEMVLQRQSSlmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAE-QRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKT
 . ||. ...   ..||.|.||  |   .| .| .  |  . .|| ...|| ..|. |. .| .|     ||.| |.|. |...|.
rkevlkltek..ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_CG7180_pd Subfamily CG7180 1189-1439 1.2e-46 153.8 In-house 36-290 (296) alignment 
Range on Protein: 1189-1439
Range on HMM: 36-290/296.0
FAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEGTAfDFWRMIADQNVTTVVMLSDETDWSD-VEKYWPIDG
 . . ||. |||.   ||.|. ||.|.   |...| ||||... ..    .||  . |. |    .|||.. |... .||.|....| .  . .||| ..
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvd.efWrlvydeeisavvvLtktfdfakmypsywpnks

sgtECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMK------DNESMPANQ-EVVQYSYTGWPSDSIVPKSANSLMNLIEMVLQRQSSL--MGSQAPIV
   . ..|     . |  |.|..  .. ||..    |       .. . |..  | .. .| |...  || |.|.|..|...| . .        ..|.|
...keqyge....ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
|.. .|.| ||... |       . |...|||. || |. .|| .    |.| ..|  | ...
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0041856 (Phosphotyrosine protein) phosphatases II 850-1114 3.5e-46 152.4 In-house 1-177 (182) alignment 
Range on Protein: 850-1114
Range on HMM: 1-177/182.0
NAIKNRYNDIRAFDDTRvklkkingddYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVAnlteknrqqCAKYWPDEQitrygd
|  |||| ||  .| .|          ..||||||.. .    . |||.|.| . |. ||.||..|.   .||...         .  |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

iivepasfsfhsdyairafdiahigecgpdvipngngveyanvpivkgqfannSRRILQYHFTNWNDYKAPEcSTGLLRFMYRLRElpqfNNSPVVIHCS
                                                      | ..||....| |. .|.    ||.|. . .|    .. ||..|||
.....................................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCs

AGVGRTGTFISIDSMLDQclaedKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYGDTD
||||||||.. .. |. .     . ...| |. .|..|. ||....||.|.. || |......|.
aGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1187-1440 5e-46 152.0 In-house 36-278 (315) alignment 
Range on Protein: 1187-1440
Range on HMM: 36-278/315.0
SNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVsEGTAFDFWRMIADQNVTTVVMLSDET--DWSDVEKYWP
 . | ...|  ||||.  .|.|. ||.|     . || |||||.||..     |||.| |  . .  |||||. ...|||.||...    |     .|||
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPl.kasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

iDGSGTECHFGSernsVNVTCVSEEHHQDFIIRNLsySMKDNEsmpANQEVVQYSYTGWPSDSiVPKSANSLMNLIEMVlqrQSSLMGSQAPIVVHCRNG
 |  .   .|||    ..|. .| |   | ..|.|   ... |   . . | |. .|.||    |.| . ||..||  |   ...    . ...|||  |
.drkadsvefGs....ikvellsleadtdgvarkl..vtrkse...esrtvtqfqftewPdkG.vdkqtssllklikev...kadngkkefsllvhcsaG

SSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
   .|..| |     . | .. .|||..|| |...|| .    |.|.| | |. ... 
vGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1162-1440 1.4e-45 150.3 In-house 9-294 (301) alignment 
Range on Protein: 1162-1440
Range on HMM: 9-294/301.0
TTSNGETGLEEEFKKLERNLTTplSSNFAAKDENLLKNRYEAAVPFDKYRVILPPT--IGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMI
.... ....||..|.|...     |..   ..||   ||..  ...|. |.|| |.  .  .  .|||||.|.||     .||||.|. . |  ||||.|
vaakhsnkfeeqykelkegedk..sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkk.tlvdfWrli

ADQNVTTVVMLSDETDW--SDVEKYWPiDGSGTECHFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNES------------MPANQEVVQYSYTGWPS
 .. ....||. .. .   |  |.||| ... .. .||     ..|| |.|  . ||.||.|.  ..|  .              . ..|.|.  | || 
wqekpvsivmvtnlkegtkskceqywp.nseaeseefg....pftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpq

DSIVPKSANSLMnLIEMVLQRQSSLMGsqAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
| .|.  .  |.  |. |..|| .  |  .|.|||| .. | ||... .|.     |||  .|||| .| ..  .| . |  |||.. | ..  |..
dGvvreprtvLq.viddvihrqqkigg..gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1163-1440 3.3e-45 149.3 In-house 15-279 (287) alignment 
Range on Protein: 1163-1440
Range on HMM: 15-279/287.0
TSNGETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPptigHADSSYINASHIKGYF--FDYIAAQDPVSEgTAFDFWRMIADQ
. .|..| .. |. ||.   .. .   .   .|  |||..  .. |.|||.|       .  ||||..|.||     .|.|. |... || .||..| |.
hakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn.tarnfWkliddr

NVTTVVMLSD--ETDWSDVEKYWPIDGSgteCHFGSernsVNVTCVSEEHHQDFIIRNLSysMKDNESMPANQEVVQYSYTGWPSDSIVPKSANSLMNLI
|||..|||..  |.| .   .||| . |     .|      |.. ..||.....|.|.|   .| ...  ..|.|.|| .| |.|   |.. . .|. . 
nvtaivmlcqekendeevcyqyWpeeks...vvlGe....yniellneevnagyierkle..vknknkagdkqqvkqyqitnWdstgkvtepqtillvie

EMVLQRQSSlmgSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
||. ... .   ....||||| ..   |..|. .     . | |  ||||| .|  .  .| .    ||| | . ..  |..
emyktqrkr...gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1170-1442 1.3e-44 147.4 In-house 7-271 (274) alignment 
Range on Protein: 1170-1442
Range on HMM: 7-271/274.0
LEEEFKKLERNLtTPLSSNFAAkdeNLLKNRYEAAVPFDKYRVILPPTIGHAD-SSYINASHIKGYFFD---YIAAQDPVSEgTAFDFWRMIADQNVTTV
||.|| .|  |  ..   . .    .  ||||.. .| .. ||.| .  .... |||||| .||||  .   |.|.| |... | .||||||  ..|. .
lekeflelPlnf.dqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpn.tvadfWrmiyqeevqvi

VMLSD--ETDWSDVEKYWPidgSGTECHFGSERNSVNVTCVSEEHHQDFIIRNLSYSMKDNesmpaNQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQ
||| .  |.. .  ..|.|     ....   . . |... ..  ...|. .|.|. .   .     ...|. | || || |  .|..||.|..|.. | .
vmltklkeaneqkCavyfP...daedyeiserygdveikvekiverndysvrklvlkyler.....ersvkhywytdWP.dhksPddantlldlvlevee

RQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKT
 ...     ||.||||  |    |.|| ||.   . ..|. .||...|  |. .|  |    ||| . .|||. | ...
sreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 826-971 4.7e-44 145.6 In-house 15-163 (281) alignment 
Range on Protein: 826-971
Range on HMM: 15-163/281.0
FLFAQEYESLPH--FQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVM
  |..|||.| .   .  ..||...||  ||||..| |.| ||||... . .  .|||||||....|..| .||.|.|| |.. .||.|||||.  .|||
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

VANLTEKNRQQCAKYWPDEQ-ITRYGDIIVEPASFSFHSDYAIRAFDIA
|..  |... .| .||||..  ..|||..|.  . . .. |. | | . 
vtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 827-972 8.6e-44 145.0 In-house 28-178 (298) alignment 
Range on Protein: 827-972
Range on HMM: 28-178/298.0
LFAQEYESLPHFQL-----DTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLI
 .|.|.. | . .       . .....||  |||| || |.| .|| |.|...|. |||||| |....|... |||.|||. .|. ||||||.|...  |
gyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigti

VMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAH
||. ||.|... .. ||||||. ..||.| |.  |   ..|...| . ...
VmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvsk
0051429 (Phosphotyrosine protein) phosphatases II 877-1108 1.5e-43 144.8 In-house 3-225 (272) alignment 
Range on Protein: 877-1108
Range on HMM: 3-225/272.0
YSDYINANFIKSWKE---KKLFIAAQAPVDATIGDFWRMvWEQESYLIVMVANLTEKNRQQCAKYWP------------DEQITRYGDIIVEPASFSFHS
.|.||||.... .     .........| ..|. ||||. .|.    ||.. ...|..|..| .|||            ...  .||.. |   |.....
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYAIRAFDIAHIGEcgpdvipngngveyanvpivkgqfANNSRRILQYHFTNWNDYKAPECStgLLRFMYRLRElpqfnNSPVVIHCSAGVGRTGTFISI
|| .| . . ..                          |...|.....|.|.| |. .|. .  ||...  |..     . ||..|||||..||||.. .
dyilrellltllls........................agearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvval

DSMLDQCLAEDKAN--------IFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWH
. .| .  .|. ..        ..|.|  ||.||  .||. |||.|.|.||.|. 
lllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 1160-1439 3.4e-43 142.8 In-house 8-290 (297) alignment 
Range on Protein: 1160-1439
Range on HMM: 8-290/297.0
SMTTSNGETGLEEEFKKLERNLTTPlSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMI
..  ..|. || .|.... .. ..    . . .  || ||||.  . .|. || |. . ..  | ||||... ||     .||.| |. . |  |||||.
ayvkekgkrGlskeyaeirnepveG.tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkk.tvsdfWrmv

ADQNVTTVVMLSD--ETDWSDVEKYWPiDGSGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNESmpaNQEVVQYSYTGWPsDSIVPKSANSLM
 .|.| ..||     |.      .||| .....  .||.    ..|. |. |...|. .| |  .  ..|    ...|. . ...|| |  ||.||.||.
WeqevlvivmttrvvergrlkcgqyWp.leeessaefgd....lsvsnveveeeedykvrvleiknvktee...srkvthfqflsWP.dyGvPssaasll

NLIEMVLQRQSSL---MG-------SQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
...|.| ..|...   .|       |. ||||||  |   .| || . .   | . .. .||..||| |.. |  .    ||| ||| |. .| 
dvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPRA_pd Subfamily PTPRA 1000-1129 1.7e-42 140.5 In-house 187-316 (330) alignment 
Range on Protein: 1000-1129
Range on HMM: 187-316/330.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVF
 ..|| . |.||| | |   |  . |.|... ....| | . .|.|.||||||||||||| .|..|..  || | ..|||| .|| ||  |||..|||.|
ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyef

IYKALAEWHMYGDTDEDVRDFEDHYQRLCA
|||.| |...||||. ||  .| | |.| .
iykvlleyylygdteldvsslekhlqklyn
subfamily_PTPN23_pd Subfamily PTPN23 1163-1439 2e-42 140.0 In-house 10-280 (288) alignment 
Range on Protein: 1163-1439
Range on HMM: 10-280/288.0
TSNGETGLEEEFKKLERNLTTPL-SSNFAAKDENLLKNRYEAAVPFDKYRVILPptiGHADsSYINASHIKG---YFFDYIAAQDPVsEGTAFDFWRMIA
. .|.|.|...||.||..      .   |.   .  |||..  .|.|. || |    |. |  |||||..|.   .  |.||.| |  ..|. |||.|. 
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskD.DYinAsfvkdlspgcPdfiatqaPl.qstlnDFWlmvy

DQNVTTVVMLSDETDWSDV--EKYWPIDgSGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSMKDNESMpanQEVVQYSYTGWPSdSIVPKSANSLMN
.| . ..||| ....  .   ..||| |  |   .||     ..||. |... . .. |.|. ...|.. .   ..|.   .| ||.   ||.| ..|..
eqkssviVmllskeelgkpkvdrYwPed.kgetvkfgd....lsvtlksvretethvervlkletldadav...ksvshlqltsWpe.lGvPasPetllq

LIEMVLQ-RQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLR-QKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
... | .  ..    |..|.||||  |.  .|.| ..       .| .  .|. | |. |.  |  |    ||. |.| |   ..
fldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 845-1125 4.8e-42 139.0 In-house 36-299 (307) alignment 
Range on Protein: 845-1125
Range on HMM: 36-299/307.0
SNRKENAIKNRYNDIRAFDDTRVKLKkINGDdYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQI
   . |. ||||.|... | .|. .| ..|   |||| ||..    . | ||.|| | ..|. .|| |. ...   ..|.... |  . .| .||| |. 
eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

TRYgdiiVepasfsFHSdyAIRAFDIAHIGECgpDVIPNGngvEYANVPIVKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMyrlrELPQFNNSPV
 .     |      | .  | ..  .| .|     . |.    .. ||  .| ..|..|| | .. ..|| |  .|.   . . ..    |  .... ||
qkl....v......fge..apntisvanlgak..klapde...dlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll....eavrydtnpv

VIHCSAGVGRTGTFISIDSMLDQCLAED-KANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWH--MYGDTDEDV---RDFEDHYQ
|.||||||||.|| ..|  . |. .|     .. ..| .|| ||.  .|.  ||..... | |.   .| .| |..   ...|..| 
vvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeekya
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 846-973 5.8e-42 138.6 In-house 5-131 (250) alignment 
Range on Protein: 846-973
Range on HMM: 5-131/250.0
NRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQqCAKYWPDEQIT
.. .|  |||| || |.| .|| |.| .||. |||||| |.....|.|.|||.|.|. ||| ||||||.|..|  |||..||.|.... . .||| |. .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

RYGDIIVEPASFSFHSDYAIRAFDIAHI
.|||. |.. |   ..|| .| . ... 
kyGdvtvsllskeefadytkrklklska
subfamily_PTPN9_pd Subfamily PTPN9 844-973 2.4e-41 136.7 In-house 36-167 (297) alignment 
Range on Protein: 844-973
Range on HMM: 36-167/297.0
ASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWP--D
||. . |  ||||.|.  .|.|||.|.|...|..||||||||.  .|.|| |||.| |.. |. ||||||||||   |||.. . |. | .|..|||  .
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWplee

EQITRYGDIIVEPASFSFHSDYAIRAFDIAHI
|. ...||. |.  .   ..|| .| . | ..
essaefgdlsvsnveveeeedykvrvleiknv
0049772 (Phosphotyrosine protein) phosphatases II 843-1107 2.5e-41 137.8 In-house 39-279 (314) alignment 
Range on Protein: 843-1107
Range on HMM: 39-279/314.0
VASNRKENAIKNRYNDIRAFDdTRVKLKKINGDDySDYINANFIKSWkekKLFIAAQAPVDATIGDF----------WRMV--WEQESYLIVM-------
....  .|  |||| ||  .| .||.|.. .... ||||||.....    . |||.|.| . |. ||          ||||  ... .  |||       
lvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VANLTEKNRQQCAKYWPDEQitrygdiivepasfsfhsdyairafdiahiG-------Ecgpdvipngngveyanvpivkgqfann
                .|.... . .|..... .                              .                                   
delsrLdaAlgKtpllildgngneptaadlellk..............................eelydpelf...........................

SRRILQYHFTNWNDYKAPeCSTGLLRFMYRLRELpqFNNSPVVIHCSAGVGRTGTFISIDSMLDQClaedKANIFEFVCNLRRQRN-----LMVQSLEQY
.|....|. ... |. ||  .  ...|.  ..|.   ...||..||.||.||||||. .. .. ..    . .. | .  .|..|       ....||||
erlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqy

VFIYKALAEW
.||..|| |.
efilealley
0036282 (Phosphotyrosine protein) phosphatases II 878-1102 2.6e-41 136.6 In-house 2-164 (174) alignment 
Range on Protein: 878-1102
Range on HMM: 2-164/174.0
SDYINANFIKSWKEKKLFIAAQAPVDatigdFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDeqitrygdiivepasfsfhsdyairafdiahigecg
||||||.... .   . .|| |.| .     ||.|..|. .  .||. .. |...  |  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

pdvipngngveyanvpivkgQFANNSRRILQYHFTNWNDYKAPECSTgLLRFMYRLRELPQF-NNSPVVIHCSAGVGRTGTFISIDSMLDQCLaEDKANI
                         .| ..||....| |. .|. |. ||.|. ...|  .  .. ||..|||||||||||.. .. || . | |.  ..
....................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvda

FEFVCNLRRQRNLMVQSLEQYVFIYK
...|  ||.||  |||. .|| |.|.
ldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN13_pd Subfamily PTPN13 1171-1437 5.1e-41 135.7 In-house 14-267 (273) alignment 
Range on Protein: 1171-1437
Range on HMM: 14-267/273.0
EEEFKKLeRNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILpptigHADSSYINASHIKGY----FFDYIAAQDPVSEgTAFDFWRMIADQNVTTVV
.||||.| |.| . .... . |.||  ||||   .|.|. ||.|      ....|||||.||       ..|||.| |. | |. |||.|. .|... ..
aeefkel.relkpldtcevgkkkenkdknryrnvlPydetrvkl.....gdeggyinaslikvpvgkdeyeyiacqGPlPe.tvkdfwqmvweqkaevia

MLSDETDWSDV--EKYWPIDGSGTeChfgSERNSVNVTCVSEEHHQDFIIRNLsySMKDNESMpANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVlqr
|.. | .   |  ..|||   . .       .| ..|. .  .....| .|.|   .||.||  . .||..  .. || |  ||.||..|....  |   
mvtlekekgkvkchrywPesknkk.l...kvsnrlevellkvqkldgfvvral..avkdsesg.esrevahlnfvkwP.dhgvPssaaellqfvaev...

qSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALAD
  .|  ...||||||  |   ||..|.|  .    . .. .|| ..|. |.  |  .    .|| |.|.|. .
.rrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPN3_pd Subfamily PTPN3 1173-1435 8.3e-41 134.7 In-house 20-271 (280) alignment 
Range on Protein: 1173-1435
Range on HMM: 20-271/280.0
EFKKLERNlTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPptigHADSSYINASHIK------GYFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVV
.|..| |     |. . | | ||| ||||   .|.|. ||.|     .... ||||....      |    |||.| |... || |||.|. .|.....|
qfeqlyrk.kpglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlak.tatdfWqmvweqkssliv

MLSDETDWS--DVEKYWPIdgSGTECHFGsernSVNVTCVSEEHHQDFIIRNLSysMKDNESmPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQR
|| . ..       .|||   .. |...|    . .|.| .|.... ...|.|   .||.|.   .....|  |. || |. ||..........| | . 
mlttlverGrvkChqyWPe..tedeleyg....efsvkcekedetksyvlrelv..lkdket.keerkilqlqylaWp.dhgvPddsadflefvervrkl

QsslMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRAL
.    |.. |.||||  |   .|..| . .    . |.. . . . |. ..  | |.    .|| |   |.
r...sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1166-1439 1.2e-40 134.6 In-house 21-288 (325) alignment 
Range on Protein: 1166-1439
Range on HMM: 21-288/325.0
GETGLEEEFKKLERnlTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNvT
 . |.  ||. |      . . . |.| ||  |||..  |..|| ||.|      ..| |||||... .     ..||| | .. |  |.||.. | . .
dqdgfahefgllps..ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlta.tindlWrlvldWr.c

TVVMLSDETDWSD--VEKYWPIDgSGTECHFGSernsVNVTCVSEEHHQDFIIRNLSysMKDNeSMPANQEVVQYSYTGWP--SDSIVPKSANSLMNLIE
.||.. .| |  .    .||| .  |   .||.    ..|  .. |.  |.. | |   .|.  .    . | |. . .|.       | .  |...|..
svvvvlneldlgkdrcavywpke.mgksktfGg....levklrtieeisdyvhrvld..vkqv.kkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

MVLQRQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
 | .|  .   . .||.||| .|   .|.||..  .  .   | |.|.|. || |. .|| |    .||...| ||....
avservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1002-1131 3.5e-39 129.7 In-house 176-306 (319) alignment 
Range on Protein: 1002-1131
Range on HMM: 176-306/319.0
NSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF-NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFI
..|.. ....|.| | . || .|.|| .. |.|.  .  .. |.|.||||||||||||| .| ||..   |   ..|..| .|| |||.|||  ||| ||
etRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfi

YKALAEWHMYGDTDEDVRDFEDHYQRLCASN
|.|| |.   |||. .|.|..|  ..|   .
yealleaveagdteievqdlrdrlkqlaekv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1174-1441 1.2e-38 127.6 In-house 1-266 (270) alignment 
Range on Protein: 1174-1441
Range on HMM: 1-266/270.0
FKKLERNLTTPLSSNFAAKDENLlkNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF---FDYIAAQDPVSeGTAFDFWRMIADQNVTTVVMLSD
||.|... |.. .   ||....|  |||.  .|  . ||.|..      . |||| ...|.      ||||. |.   | ..||||| ...||..||...
fkeldkeetsesdlpeaargkkl..nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlp.ttlksfwrmiweekvtaivmttg

--ETDWSDVEKYWPIdgsGTECHFGSERNSVNVTCVSEEHHQDFIIRNLSYSmKDNEsmpaNQEVVQYSYTGWPSDSIVPKSANS--LMNLIEMVLQRQS
  |   .  |.|||     .. .   |   ..|. .|||... .|...|    .. |    ....| . |. || ....... .|    .|..|. . . 
leEkgrkkCerYWpa...epkekvkledgkikvlalseekeegyiltrlrle.ekge....errlvHfwyntWpdhgvpreedsslstdqllkmlravrr

--SLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
  . .  . |..||| .|   .|..| .       . ....|| . .. |  .|. .    ||| | |.|.. |...
sekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 998-1133 1.6e-38 127.6 In-house 169-305 (318) alignment 
Range on Protein: 998-1133
Range on HMM: 169-305/318.0
QFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELP-QFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQ
.  ..|| . |||.|.| |   || ...|| .. . ..   . ...|.|.||||||||||.|| .|..|..  ||   ..|..| .||.|||||||  .|
teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedq

YVFIYKALAEWHMYGDTDEDVRDFEDHYQRLCASNRD
|.|||..| |  . |||. | .|. .. ..|  .. .
yefiydvllealasgdtevdasdlrsrirelreqdpe
subfamily_PTPN12_pd Subfamily PTPN12 841-975 3.5e-38 126.1 In-house 31-168 (290) alignment 
Range on Protein: 841-975
Range on HMM: 31-168/290.0
DTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWP
 | |....||  |||| ||  .| .||.|.||.... ||||||||||  ..|. .||||.|. .|. |||||.||..  ..||. .. | ....|..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DE--QITRYGDIIVEPASFSFH-SDYAIRAFDIAHIGE
.|  . ...|.. |.  .      |. ||.. . . .|
eegeeelefgefevtleeekavdddflirtLkveaqke
0043147 (Phosphotyrosine protein) phosphatases II 874-1101 4.3e-38 126.1 In-house 1-154 (172) alignment 
Range on Protein: 874-1101
Range on HMM: 1-154/172.0
GDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLteknrqqcakywpdeqitrygdiivepasfsfhsdyairafdiahi
||..||||||.... .   . ||| |.| . |. |||||..|.   .||.. .|                                              
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................

gecgpdvipngngveyanvpivKGQFANNSRRILQYHFTNWNDYKAPeCSTGLLRFMYRLRE-LPQFNNSPVVIHCSAGVGRTGTFISIDSMLdqclaeD
                           . .| ..||....| |. .|  .  ||.|.  ..| | . .. ||..|||||||||||.. .. ||       
......................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......l

KANIFEFVCNLRRQRNLMVQSLEQYVFIY
. ...| |. .|..|. .||. .|| |.|
glsleeavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 848-1108 9.6e-38 124.6 In-house 46-287 (305) alignment 
Range on Protein: 848-1108
Range on HMM: 46-287/305.0
KENAIKNRYNDIRAFDDTRVKLkkiNGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQitry
 ..| |||| |.  .|. ||||   .|    .|| ||.. .  . | || .|||.. |  ||| | ...    | |. || ||  ..|..|.. ..    
aqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd....

GDIIvepaSFSFHSDYAIRAFDIAHIGecgpDVIPNGNGVEYANVPIVKGQfANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRElpqfNNSPVVIH
.|..    .|. . .  .  |. ..      .   . . .  . | ...|   ...|.. .||. .| |   |   . .| .. . |        |.|.|
kdvl....efeekgqkisvkfessvtl....kfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellekarp....skgpivvh

CSAGVGRTGTFISIDSMLDQCLAEDKANIFE-FVCNLRRQRNLMVQSLEQYVFIYKALAEWH
||||.||||. . .. .||| || .. .  .  .  .| |||  .|. .||.|... . .. 
csagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0046846 (Phosphotyrosine protein) phosphatases II 872-1107 9.9e-38 125.0 In-house 6-172 (176) alignment 
Range on Protein: 872-1107
Range on HMM: 6-172/176.0
INGDDYSDYINANFIKSWKekklFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDeqITRYGDiivepasfsfhsdyairafdia
.  | ..||||||.| . .    .|| |.|.  |. ||..|..|.  ...|.. ...|..| .|. |||.  ....|                       
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi......................

higecgpdvipngngveyanvpivkgqfannsrrilQYHFTNWNDYKAPECsTGLLRFMYRLRELPQfNNSPVVIHCSAGVGRTGTFISIDSMLDqclaE
                                    ||....| |. .|.  . ||...  .||  . .. ||..|||||.|||||.. .. .      |
....................................qylhlpwpDhgvpdl.elllellefirealk.eggpvlVHCsaGigRtgtlvaayllel....e

DKANIFEFVCNLRRQRN-LMVQSLEQYVFIYKALAEW
   ...| .. .|.||   .||. ||| |.|... ..
kglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 840-974 1.4e-37 124.7 In-house 51-179 (319) alignment 
Range on Protein: 840-974
Range on HMM: 51-179/319.0
LDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVAnlteknRQQCAKYW
 |   .| ..|  |||. .| ||| ..|||....| ..|||||| |.. .. |. .|||| | | |. |||||.||...  ||...      ...|..||
adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqyw

PDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIG
| .   ...   |.  |    ..|..| ..... |
plkivikeerfkvkvdsveetaeyvvrdielsedg
subfamily_PTPRN_pd Subfamily PTPRN 1167-1439 2.6e-37 123.2 In-house 28-292 (297) alignment 
Range on Protein: 1167-1439
Range on HMM: 28-292/297.0
ETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGY---FFDYIAAQDPVSEGTAfDFWRMIADQNVT
.. ||.|.. | .  . | ... | ...|. |||..|..|.|. || |  .  . .| ||||| |         |||.| |...  | |||.|. .| |.
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastva.dfwqmvweqGvv

TVVMLSD--ETDWSDVEKYWPIDGSGTECHFgsernsvNVTCVSEE-HHQDFIIRnlSYSMKDNESMpANQEVVQYSYTGWPSDSiVPKSANSLMNLIEM
 .|.|.   |.. . ...||| .|| .   .       .|  |||    .|...|  |. .|. ..    . | |. .  ||. . || ||.||...   
vivnltrleeegvkqckrywpdeGsevyhiy.......evhlvsehiwcddylvr..sfylknlqts.etrtvtqfhflswpeeg.vPasaksllefrrk

VlqrQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLR-QKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
|   . |  |  .|||||| .|.  .|..| | |.  | .|  ..||.  |.. |.  || .    .|. |.. |.|. .
v...nksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1000-1129 4.2e-37 123.1 In-house 181-312 (319) alignment 
Range on Protein: 1000-1129
Range on HMM: 181-312/319.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNN--SPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQY
 .. |.| |.||  | |.  |. .. |.|.. ..| | . .|   ..|.||||||||||..| .| .||.   |.. ....|| .||.||| .||.| ||
ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFIYKALAEWHMYGDTDEDVRDFEDHYQRLCA
 ||| || | |..| .|  . ||  ....| .
kfiysalleehlfghsdvampdfpayleelsn
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 841-974 4.6e-37 123.0 In-house 16-143 (284) alignment 
Range on Protein: 841-974
Range on HMM: 16-143/284.0
DTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVAnlteknRQQCAKYWP
|   .| ..|  |||. .| ||| ..|||... | ..|||||| ||. .. |. .||.| | | |. |||||.||...  ||...      ...|..|||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

DEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIG
 .   ...   |.  | .  ..|..| ..... |
lkivikeerfkvkvdsveeseeyvvrdielsedg
subfamily_ptpA1_pd Subfamily ptpA1 842-1065 8.8e-37 121.8 In-house 39-253 (418) alignment 
Range on Protein: 842-1065
Range on HMM: 39-253/418.0
TVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEkKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPd
|   ..| |. |||| .|   . |||.||||.  . |||||||.|      | ||..| |.  || ||||||||.   .|||..  .|. | .| .||| 
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywp.

EQITRYGDIIVEpASFSFHSDYAIRAFDIahIGECGPDVIpngngveYANvpiVKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRE-----L
|||      |           |..   ..  | .   ..|         |   ..  |  ..| | ||..  | |.. |. .  . .... . .     .
eqiggeqfsiyg.ngnevfgtysvelvev..iqdpereii.......trn...irltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii

PQF-NNSPVVIHCSAGVGRTGTFISIDSML
|    | |...|||||||||||| .   |.
pssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1000-1129 1.8e-36 121.1 In-house 145-276 (284) alignment 
Range on Protein: 1000-1129
Range on HMM: 145-276/284.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNN--SPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQY
 .. |.| |.||  | |.  |. .. |.|.. ..| | . .|  ...|.||||||||||..| .| .||.   |.. ....|| .||.||| .||.| ||
ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFIYKALAEWHMYGDTDEDVRDFEDHYQRLCA
 ||| || | |..| .|  . ||  ....| .
kfiysalleehlfghsdvalpdfpayleelsn
0049260 (Phosphotyrosine protein) phosphatases II 886-1102 2.2e-36 120.2 In-house 2-144 (152) alignment 
Range on Protein: 886-1102
Range on HMM: 2-144/152.0
IKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWpdeqitrygdiivepasfsfhsdyairafdiahigecgpdvipngn
|. .. .. |||.|.| . |. |||||..|.    |||. .|.|... .|..|.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

gveyanvpivkgqfannsrrilQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLdqclaeDKANIFEFVCNLRR
                      ||....| |. .|. |  || ..  ...| . .. ||..|||||||||||.. .. ||       . ...|.|  .|.
......................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvre

QRNLMVQSLEQYVFIYK
.|. .|.. .|. |.|.
kRpgavpnpgqlrflye
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1168-1434 2.6e-36 120.0 In-house 6-261 (283) alignment 
Range on Protein: 1168-1434
Range on HMM: 6-261/283.0
TGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGhadsSYINASHIK-----GYFFDYIAAQDPVSEgTAFDFWRMIADQNV
.. .  ...|.|    .|... |. |||  |||..  || |..|| | .       .||||..|          .||.|| |. . |  |||.|. |...
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldr.tvvdfWkmvfdeki

TTVVMLSD--ETDWSDVEKYWPIDGSgteCHFGSernsVNVTCVSEEHHQDFIIRNLSysMKDNESMPANQEVVQYSYTGWpsDSIVPK-SANSL--MNL
|..|||.   |       .||| .||     .|       ||   |  .. |||..|   .. | |  ..  .  | . .|   .. ..   |||  .|.
taivmltklqedlrikCsqyWPkrGs...edyGe....ftvtlrkettsnsfiikell..lrvnssakstlllahyqvidW..leygeqaiinslvkfnk

IEmVLQRQSslmgSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRA
.   ||..|     ..|||||| .|   ...|| .|      ..|  .|||..|| .. .|.|.    .|| . . .
vi.slqtes....kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 808-968 4.1e-36 119.4 In-house 3-164 (315) alignment 
Range on Protein: 808-968
Range on HMM: 3-164/315.0
IPVDDLPTeYVVRHRDTDfLFAQEYESLPHFQLDTVASNR-KENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATI
||| ..|. .| . | |  ||..|.  ||  .     . | ..|  ||||..|  .| .||||. |. .  |||||| .||| .. | .||.|.| .|..
ipvaqfpa.fvnknrhta.lfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

GDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPD--EQITRYGDIIVEPASFSFHSDYAIRAF
 ||||||....   ||||... | .. .|..||||   . ...| | ||  | .  .|  .| .
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 830-1106 4.7e-36 119.3 In-house 23-269 (288) alignment 
Range on Protein: 830-1106
Range on HMM: 23-269/288.0
QEYESLPHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKkingDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTE
.||.  |      ....  .|. ..||...   | |||||.    ||   ||.|| . | | |. .| ||||...||. .|.|. |..   |||...| |
keyrdspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcelle

KNRQQCAKYWPDE--QITRYGDIivepasfsfhsdyairafdiahigeCGpDVIPNGNGVE-YANVPIVKGQFANNSRR-ILQYHFTNWNDYKAPECSTG
| ... |.|.| .  . .|.| .                         |  .|  . ....   .| ... .   . .  . . |. .|.|   ||    
kGkeksaeyfPsklGekarigrl.........................ct.vvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenyls

LLRFMYRLrelpQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAE
 ||.. .|    .  . |.|.|.|||||||||.| |  .|..   .|   | ... .|| .|   .|.  ||..... . |
plrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 808-970 6.1e-36 118.6 In-house 2-165 (515) alignment 
Range on Protein: 808-970
Range on HMM: 2-165/515.0
IPVDDLPTeYVVRHRDTDfLFAQEYESLPHFQL--DTVASNrKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDAT
.|. ..|. .| . | |  ||..|.  ||  ..  .||| . . |  ||||..|  .| .||||. || .  |||.|| .|.| .  | .||.|.| .|.
lplaqfPa.fvnknrhtt.lfseefhdlpgpniypqtvaqe.einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

IGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPD--EQITRYGDIIVEPASFSFHSDYAIRAFDI
. ||||.|....   |.||..| | .. .|.|||||   .  ..| | ||  | .  ..  .| . .
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 807-970 1.1e-35 118.2 In-house 9-168 (297) alignment 
Range on Protein: 807-970
Range on HMM: 9-168/297.0
AIPVDDLPTeYVVRHRDTDFlFAQEYESLPHF--QLDTVASNRkENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEkkLFIAAQAPVDA
 ||. |..| .| . |.||. | .|.  ||.   | .||| ..  |  |.||..|  .|  ||||. .| |  |||.|| |.|. |.   .|. | | .|
piplsdfat.lvqknrhtdv.fseeflclpeaniqpqtvaekk.vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TIGDFWRMVWEQESYLIVMVANLTEKNRqQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDI
|. |||.||....   |||.... |... .||.||.|. .| .||. |.  | |  . .  | ...
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelev
subfamily_PTPN14_pd Subfamily PTPN14 1187-1442 1.5e-35 117.7 In-house 41-299 (300) alignment 
Range on Protein: 1187-1442
Range on HMM: 41-299/300.0
SNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHaDSSYINASHIK----GYFFDYIAAQDPVsEGTAFDFWRMIADQNVTTVVMLSDE--TDWSDVEKY
 . |. .||  |||..  .|... || | ||    .. |||||.||    |   .||.|| |. | |  |||.|. .|.|. .||| .|         ||
lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPl.eltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPIDGSgTECHFGSERnsVNVTCVSEEHHQDFIIRNLSysMKDNESMpANQEVVQYSYTGWPSDSiVPKSANSLMNLIEMV--LQRQSSLM----GSQAP
.| ..|  . .   ..   .||    |. . .| . |   .|   |   ...|.   || || .  ||.  .. .. .|.|  ..|... .     |. |
fPkles.kkktvefgk..fkvttkfsedsdsvittglk..lkhlpsk.eertvwhlqytDWpdhg.vPeDvkgflsyLeevqsvrrktnseveskeskPP

IVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKT
..||| .|   .|. |   ||    . ...||. .... |.  | ..   . || | |..|  |. ..
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
0049772 (Phosphotyrosine protein) phosphatases II 1156-1442 1.8e-35 118.6 In-house 7-283 (314) alignment 
Range on Protein: 1156-1442
Range on HMM: 7-283/314.0
SSRESMTTSNGETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDkYRVILpPTIGHADSSYINASHIKGYfFDYIAAQDPvSEGTAFDF--
.| . .....  ..|. ... .. .....|.  .| . .|  ||||   .|.|  |||| |. .. .|.|||||...|.  ..||.| | .| | .||  
asfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.lkfIatqgp.leitvvdfre

--------WRMI--ADQNVTTVVMLSDETDWSDVEK---------YWPIDGSGtechfgsernsvnvtcvSEEH-------HqdfiirnlsysM------
        |||.   |.|| ..||  ||  ......         . ..|| |                 .| .       .                  
epvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.................neptaadlellk...........eelydpe

-KdnesmpaNQEVVQYSYTGWPSdSIVPkSANSLMNLIEMVLQRqsslmGSQAPIVVHCRNGSSESGIFICISLLWLRQkaeqRIDVFQTVKGLQSHRP-
          .....| .. .|    .| . . .  ..|....        . |..|||. | . .| |... .| ...    .... .... ... || 
lf.......erlgikylripvpD.gsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpi

----MMFTRFEQYSFCYRALADYISKT
     ..  .||| |...|| .|... 
npnpgfieqleqyefilealleylkfl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1172-1436 2.6e-35 116.6 In-house 24-233 (392) alignment 
Range on Protein: 1172-1436
Range on HMM: 24-233/392.0
EEFKKLERNLTTPlsSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFF--DYIAAQDPVSeGTAFDFWRMIADQNVTTVVMLS
|||. |      |   . | |. || ||||.  .|.|. ||.|      .|| |.|||.|...     |||.| | .  .  |||||. ..||||..|..
eefhdlpgpdiyp..qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpna.aslddfwrmvfqenvttiamvt

D--ETDwsdvekywpidgsgtechfgsernsvnvtcvseehhqdfiirnlsysmkdneSMPANQEVVQYSYTGWPSDSiVPKSANSLMNLIEMVlqrqSS
.  | |                                                        .. | |. .| || .  ||| ..||...|. |    ..
klkegd....................................................kgddartvaqfhftewPdkd.vpkhtssllkfikev....ka

LMGSQA-PIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALA
  |. . |...||  |   .|. |.|  .  . |  . .|||. |  .. .||.|    |||.| | |. 
dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 826-972 3e-35 116.9 In-house 23-171 (325) alignment 
Range on Protein: 826-972
Range on HMM: 23-171/325.0
FLFAQEYESLPHFQL-DTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMV--WEqeSYlIV
  ||.|.. ||  .     .. . ||  |||.... |.| .|| |.  . |  ||||||..... |.|. |.|||||  |||.|.||.|  |.  .  .|
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..cs.vv

MVANLTEKNRQQCAKYWPDE--QITRYGDIIVEPASFSFHSDYAIRAFDIAH
.| |  ... ..||.|||.|  .  ..| . |.  .    |||  | .|.  
vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkq
subfamily_PTPRB_pd Subfamily PTPRB 1000-1107 5.1e-35 115.9 In-house 175-284 (293) alignment 
Range on Protein: 1000-1107
Range on HMM: 175-284/293.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELP--QFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQY
....|.. ||||| | |.  || .. ||.|....||    . ...|.|.|||||||||||||..| .|..   ||  .|| .|..||..|||.||. .||
ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqY

VFIYKALAEW
.||.... . 
ifihqcvldl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 845-1105 5.2e-35 115.8 In-house 42-341 (350) alignment 
Range on Protein: 845-1105
Range on HMM: 42-341/350.0
SNRKENAIKNRYNDIRAFDDTRVKLK--------KINGDDYSDYINANFIKSW-----KEKKL-FIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEK
|.  |   ||||..|  .. .|||||        |      .||||||..|        . .  .||.|||.  |. ||.... . .  .|...... | 
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

NRQQCAKYWPDEQITR-YGDIIVEPASFSFHSDYAIRAFDIAHIGEcGPDVIPNGNGVEYANVPIVKGQFANNSRRILQYHFTNWNDY---KAP------
|...| .||.. ..      .     .     | .....|. .      | | . | ..  |  .     | .   ..| .. ||.|      |      
nlekcyrYWqegsydditvklaskwenimgindsslysadvkkeas.dndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqa

-ECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLD---------------QCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKAL
 |.   |.  ..    | . . ||...|||||||||||....||.|                .  |. .  |.  | .||.||  |||.|.|..|||.||
levkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal

A
 
l
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 848-1103 1.1e-34 114.4 In-house 50-285 (310) alignment 
Range on Protein: 848-1103
Range on HMM: 50-285/310.0
KENAIKNRYNDIRAFDDTRVKLKkINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITR-
|..  |||| |.   |..||||| |.   | ||| ||..|.   .. || .| |.. || |||||.... .  |... . .|. | .|  |||   .|  
kkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGDIIVEpaSFSFHSDyairAFDIAHIGEcgpDVIPNgngveyaNVPIVKgQFAN-NSRRILQYHFTNWNDYKAPECSTGLLrfmyRLRELPQFNNSPVV
|| | |    .|  |.     |.|  .       .|.       |||. . | || .  |.   .. || |   |.     .      | | |    |.|
ygcirvt..nlsesse....efeicnlav...tfvpd.......nvpvde.qpanlkelrvslikwpnwpdrgvpdekchtv....pqrllaqvrhgpcv

IHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKA
.|||||..|... ....  .|.    .| .. | . .|...|   .|.  ||..| . 
vhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
0044763 (Phosphotyrosine protein) phosphatases II 862-1112 1.5e-34 114.6 In-house 2-175 (178) alignment 
Range on Protein: 862-1112
Range on HMM: 2-175/178.0
FDDTRVKLKKINGDDYSDYINANFIKSWkekkLFIAAQAPvdatiGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQItrygdiivepasfsfhs
.|.|||.| .. |  .||||||..|       |..... |      |......|.   .||.... .| ....| .|||.|                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

dyairafdiahigecgpdvipngngveyanvpivkgqfannsrriLQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISI
                                             .||..... |...|. .  .|.|.  ..|. . ...||..||||||||.||.. .
.............................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaa

DSMLDQclaedKANIFEFVCNLRRQRNlMVQSLEQYVFIYKALAEWHMYGD
. |. .     . ...| .  .|..|. .|.. .|. ..|.   ... ..|
ylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
0041856 (Phosphotyrosine protein) phosphatases II 1195-1438 1.9e-34 114.3 In-house 1-170 (182) alignment 
Range on Protein: 1195-1438
Range on HMM: 1-170/182.0
NLLKNRYEAAVPFDKYRvilpptighaDSSYINASHIKGYFFD--YIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSdetdwsdVEKYWPidgsgtechf
|| ||||.  .|.|  |          |..||||. . |.. .  .||.| |  . |  ||.||. ....||.|.|.        | |||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgplls.tvadflrmlkelgittivnlt.......eelywp..........

gsE-RnsvnvtcvseehhqdfiirnlsysmkdnesmpaNQEVVQYSYTGWPSDSIVPksANSLMNLIEMVLQrqsslmgSQAPIVVHCRNGSSESGIFIC
  |                                   .....|| |..|| ... .   ..| ..||.||.       .. |..|||. | . .| ...
..ell.................................erlgiqylylpwpDhgvpd..ldelldfieevle.......eggpvlVHCsaGvgRtgtlva

ISLLWLRqkaeqRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADY
. |.. .     .......|| ..|.||.|... .|| |...|| ..
aylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1171-1438 2.6e-34 113.4 In-house 23-278 (439) alignment 
Range on Protein: 1171-1438
Range on HMM: 23-278/439.0
EEEFKKLERNLTT-PLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFFD--YIAAQDPVSEgTAFDFWRMIADQNVTTVVM
.|.|.|..         ...||.. .  ||||.  ..||  ||.|  . |   | |||| .||||. |  |||.| |  | |. ||||.. .....|.||
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkke.ttddfwrlviekktvtivm

LSDETDwsdVEKYWPIDGsgtECHFGSernsVNVTCVSEEHHQDFIIRNLSYsMKDNESMPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQSS
|..  .     |||| |.   |. .|     . | .  .    ...|| .   ... ..   .. |.|. |. || |  ||  |  .....  .   . .
ltnlve...sykywpsda...evcygd....iavrvdrnielpnyvirgfkv.fnerdttekertvlqfhyiawp.dknvpaqashvldflrainsandk

lmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADY
      |.||||  |   .|  |.. .   . |.|...|.   || |. .|  |   . || | | |. . 
..eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
0051429 (Phosphotyrosine protein) phosphatases II 1223-1439 1.2e-33 112.3 In-house 4-225 (272) alignment 
Range on Protein: 1223-1439
Range on HMM: 4-225/272.0
SSYINASHIKGYfFD------YIAAQDPVSEgTAFDFWRMiADQNVTTVVMLSDET--DWSDVEKYWP--------IDGSGTECHFgseRNSVNVTCVSE
|.||||....|| .       ..... |    || ||||. ......|.|.| .|.  .. ....|||        | ..... ..    . . ||..||
sgyiNardvggy.grvvkpgrlyrsggplpl.taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptil...ygalrvtllse

EHHQDFIIRNLSYSMKDNESMPanQEVVQYSYTGWPSDSIVPKSansLMNLIEMVLQrqsslmgsQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRID
|.. |.|.|.| .... . ...   || .. ||.|| ... ...   | .|.|..|.        . |..|||. | . .|..... || |.  .|. .|
ellldyilrellltlllsagea..revmhlhytdwpdhgvpqea...llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------VFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
        ....|. |...|| ..   ||| |.|.||....
dYlltnlyleeaveelraqrpgavqteeqylflyeallell
PTPc_DSPc_SM00012 1006-1106 1.7e-33 110.3 In-house 2-105 (105) alignment 
Range on Protein: 1006-1106
Range on HMM: 2-105/105.0
ILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNN--SPVVIHCSAGVGRTGTFISIDSMLDQCLAE-DKANIFEFVCNLRRQRNLMVQSLEQYVFIYK
. .||.|.| | ..|| |. .|...  ...  . ..  .|||.||||||||||||. .| .|.|. .| .. .||..|. ||.||. |||..|||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALAE
||.|
alle
subfamily_PTPN3_pd Subfamily PTPN3 840-971 1.8e-33 110.7 In-house 31-163 (280) alignment 
Range on Protein: 840-971
Range on HMM: 31-163/280.0
LDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGddysDYINANFIK----SWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQC
|.. |... ||. |||| || ..|.||||||. .     ||||||...    | .  . .||.| |.. |  |||.|||||.| ||||...|.|. |..|
laisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

AKYWPDE-QITRYGDIIVEPASFSFHSDYAIRAFDIA
 .|||.. . ..||.. |.  . . .. |..| . . 
hqyWPetedeleygefsvkcekedetksyvlrelvlk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 849-953 4.2e-33 109.5 In-house 19-128 (270) alignment 
Range on Protein: 849-953
Range on HMM: 19-128/270.0
ENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIK-SWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQIT--
 ..  |||.||     |||.|.... |. . |||||...   .||| .|||..|...|. .||||.||...  |||...|.||.|..|..||| |. .  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--RYGDIIVE
  ..|.| | 
kledgkikvl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1000-1135 1.3e-32 107.9 In-house 169-304 (315) alignment 
Range on Protein: 1000-1135
Range on HMM: 169-304/315.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVF
...||.. |..||.| |  ... .. ||...  ..   . .. ....|||||||||| .||||....|   ..  ..|.|| |||..|  .||. |.| |
seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyaf

IYKALAEWHMYGDTDEDVRDFEDHYQRLCASNRDRA
|| |. |  .. .|   |  | || | | .|   ..
iydavledllwrntlilvihftdhlqdlhtsvdgsg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 847-975 2.5e-32 107.0 In-house 44-168 (287) alignment 
Range on Protein: 847-975
Range on HMM: 44-168/287.0
RKENAIKNRYNDIRAFDDTRVKLKkingDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITR
 ..|  |||...|   |. || ||    .   ||||| ||...|||| ||.|..|.  |. .||.......   |||.....|.....| .|||.|. . 
asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGDIIVEPASFSFHSDYAIRAFDIAHIGE
.|.  .|  .   ...| .| ... . ..
lGeyniellneevnagyierklevknknk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1001-1156 2.6e-32 106.6 In-house 169-325 (515) alignment 
Range on Protein: 1001-1156
Range on HMM: 169-325/515.0
NNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLREL-PQFNnSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVF
..|| . |.|||.| |  .|. .. ||...  ..    |..  |..||||||||||| .|||||.. .    .  ..|.|| |.|..|  .||  ||| |
ddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

IYKALAEWHMYGDTDEDVRDFEDHYQRLCASNRDRAVSF-NQQSSTNGSISPRVAIVS
|| |. |  .. .|   |  | || | | .|   |  |   ..  |  |. |      
iygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasq
0051082 (Phosphotyrosine protein) phosphatases II 877-1104 3.1e-32 106.6 In-house 2-149 (151) alignment 
Range on Protein: 877-1104
Range on HMM: 2-149/151.0
YSDYINANFIKSWkekklFIAAQAPVDatigDFWRMVWEQESYLIVMVANLTEKNrqQCAKYWPDEQitrygdiivepasfsfhsdyairafdiahigec
.|||||.... .      ... ..| .    ||.....|.  . ||.. ...| .   |..|.|...                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

gpdvipngngveyanvpivkgqfannsRRILQYHFTNWNDYKAPECSTGLLRFMYRLRElpqFNNSPVVIHCSAGVGRTGTFISIDSMLdQClaedkANI
                           ...|......| |.. |..   .|.|.  |..    .| ||..|||||.|||||.. .. || .       ..
...........................ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsl

FEFVCNLRRQRNLMVQSLEQYVFIYKAL
.| .  .|..|  .||. .|..|...||
eealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 848-974 3.3e-32 106.4 In-house 36-163 (287) alignment 
Range on Protein: 848-974
Range on HMM: 36-163/287.0
KENAIKNRYNDIRAFDDTRVKLKKiNGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQI-TR
  .. |||| |.  .||||| | . .|.  |||||||.. |..... |||||.|. ||..||||.|.|..|  .....   |. |..| ||||. .   |
laavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmr

YGDIIVEPASF-SFHSDYAIRAFDIAHIG
 |   |   ..   . .|..||. .... 
vGGysvvlldydikePeygvralrlidle
subfamily_PTPN12_pd Subfamily PTPN12 996-1106 6.2e-32 105.6 In-house 162-275 (290) alignment 
Range on Protein: 996-1106
Range on HMM: 162-275/290.0
KGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISID---SMLDQCLAEDKANIFEFVCNLRRQRNLMVQ
| .. ..||.. |.|.|.| |   |.  . ||...  .||| . ...|.|.||||||||||| |.||   ..| .   ... ..|. | .||.||. .||
kveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvq

SLEQYVFIYKALAE
. |||...|||.||
tkeqyelvykavae
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 995-1113 6.7e-32 105.9 In-house 176-295 (298) alignment 
Range on Protein: 995-1113
Range on HMM: 176-295/298.0
VKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNN-SPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQS
|. .  ...|.. | |||.| |  .|| .| .| .. . |  .| .  .||...|||||||.|||| |||.|..  .| .  .|. |  ||..|  .||.
vskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt

LEQYVFIYKALAEWHMYGDT
 |||||||.|  |    ...
eeqYvfiyeavlealdsfnd
subfamily_PTPN1_pd Subfamily PTPN1 1184-1436 1.2e-31 104.5 In-house 21-268 (290) alignment 
Range on Protein: 1184-1436
Range on HMM: 21-268/290.0
PLSSNFAAKDENLLKNRYEAAVPFDKYRVILpptiGHADSSYINASHIKGY--FFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSD--ETDWSDVEK
 .. . | ..||  .|||    |.|. |..|     .||  ||||| ..       || .| |... |.  ||.|. .|.  .||||    | .     .
dfptreaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpn.tvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPIDGSGTECHFgsERNSVNVTCVSEEHHQDFIIRNLSYsmKDNEsMPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVlQRQSSLMGSQAPIVVHC
||| . .  |  .  |  ...|. .|||... ...| |    .. .     .|.... || || |  ||.| .......  | ..  ||   . | |.||
ywPqgeeekelll..edtklkvkliseerksyytvrllel..enlk.tqetreilhfhyttwp.dfgvpespaaflkflfkv.resGslssdvGpavihc

RNGSSESGIFICISLL--WLRQKAE-QRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALA
  |   || |. .  .   . .| . . .|. ...  |...|  .    .|  | | |. 
saGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1167-1440 1.9e-31 104.1 In-house 5-260 (267) alignment 
Range on Protein: 1167-1440
Range on HMM: 5-260/267.0
ETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHadssYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNVTT
|. .|.||.....  .|          .|  .||.. ..|.|. ||||  .       |||||...||     .|. |||..  |  ||. .| ||.|..
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkn.titdfltvihdqkvpv

VVMLSDeTDWSDVEKYWPID-GSGTecHFgserNSVNVTCVSEEHHQDFIIRNLSYSMKdNESmpaNQEVVQYSYTGWpsdSIVPKSANSLMNLIEMVLQ
.|.|   .   .. ..||   |     ..    . . |    |.  .|. |  |   .| |||    ..|. | |  |    |  .    |  |. .. .
ivlltk.vftdnirlfwPPkmgqak..ky....qdltvehslekeendyqiitlelkfk.nes...ahnvtlyyykkw...nintnnkpylkplfgilak

RQssLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
 |  |   . |.||.| .|   || |. |     | | |.  |.|. .. ..| |. .    |.| .... ||.|  
nq..lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1001-1106 2.6e-31 103.7 In-house 134-240 (250) alignment 
Range on Protein: 1001-1106
Range on HMM: 134-240/250.0
NNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF-NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVF
...| . |.||..| |   ||  |  | .. ...   |  .|.||...|||||||.|.|| ||..|..   | . ..|...  ||..|  .|.|||||||
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf

IYKALAE
.|... .
vyeiilk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 836-970 3.3e-31 103.2 In-house 34-163 (439) alignment 
Range on Protein: 836-970
Range on HMM: 34-163/439.0
PHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRqqc
| .. ..    .. .  ||||.|. ||| ||| |..| |  .| |||||.|| . ..||.||.|.| . |  ||||.|.|. .  |||..|| |  .   
pdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...

akYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDI
  ||| .. . ||||.|         .|.|| | .
..ywpsdaevcygdiavrvdrnielpnyvirgfkv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1000-1106 7.9e-31 102.2 In-house 166-274 (281) alignment 
Range on Protein: 1000-1106
Range on HMM: 166-274/281.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNN-SPVVIHCSAGVGRTGTFISIDSMLDQCLAE-DKANIFEFVCNLRRQRNLMVQSLEQY
 ...|.. | ..|.| |  .|. .. || |   ...| . ..  |.|||||||||||||.|..| ..... ||  .... . | .||..||||||.. ||
sgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

VFIYKALAE
 |.|||. .
efvykavld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1194-1434 5.9e-30 99.2 In-house 2-234 (237) alignment 
Range on Protein: 1194-1434
Range on HMM: 2-234/237.0
ENLLKNRYEAAVPFDKYRVILPPTIGHadSSYINASHIKGYF---FDYIAAQDPVsEGTAFDFWRMIADQNVTTVVMLSD--ETDWSDVEKYWPIDGSgt
|| .||||   | .|. ||.|  . .   | ||||...||.      ||||| |. | .  |||.|. ... . .|||.   | .     ||||      
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgpl.esscddfwqmvwqekcsvivmltgliegnelkchkywpstdq..

ECHFGsernSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpANQEVVQYSYTGWPSDSiVPKSANSLMNLIEMVLQRQSSlMGSQAPIVVHCRNGSSESGI
   .|     . |.   .|.  |. .| |  |.. .      . . || .| ||    ||. . .|. .   ...|    .   .| ..||  |   .||
paayg....vltvslkkkeefsdytvrslllskrltlk..evrlihqyqftswpdrg.vpqqtaallrfrkniinrsph.vsesgpwiihcsagvgrtgi

FICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRA
|. |  .  . | .. .|... |. ..  || .    .|| | ...
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_PTPN23_pd Subfamily PTPN23 846-953 7e-30 98.8 In-house 39-145 (288) alignment 
Range on Protein: 846-953
Range on HMM: 39-145/288.0
NRKENAIKNRYNDIRAFDDTRVKLKkingDDYSDYINANFIKSWKEK-KLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDE--
  | .. |||..||  .| .||||.    .   ||||| |.|.       |||.||| . |..|||.||.|| | .|||. . .|........||| .  
iaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg

QITRYGDIIVE
. ...||. | 
etvkfgdlsvt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 844-956 9.2e-30 98.5 In-house 26-141 (297) alignment 
Range on Protein: 844-956
Range on HMM: 26-141/297.0
ASNRKENA-IKNRYNDIRAFDDTRVKLKKINGDdySDYINANFIKSWKEKK--LFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWP
.| .....  ||||.|| |.|||||||..   .  .|||||...   .|..   .| || |..||. |||..|.||.   |||||.| |  |..|| |||
ssakrnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

DEQ--ITRYGDIIVEPAS
. .    . ||..||  |
svvqerlkagdvvvefls
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1190-1434 1e-29 98.4 In-house 3-236 (239) alignment 
Range on Protein: 1190-1434
Range on HMM: 3-236/239.0
AAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF---FDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSD--ETDWSDVEKYWPiD
| |  |  ||||   | .|. ||.|        | |||||... |      |||.|  |.  .. |||||. ..    .|||.   |     . .||| |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei.ssgdfwrmmwqerrcvivmltglieghkkkchqywp.d

GSGTEChfgsernSVNVTCVSEEHHQDFIIRNLSYSMKDNesmPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLqrQSSLMGSQaPIVVHCRNGSS
 .   |        . ||    |   |.||| .  |   .     .. | || .| || |  ||. | ... |   .   . || |.. | |.||  |  
stskyc.......nlrvtlrktevfadyiirtfvmsqvgq...teeryvyqyhftvwp.dkgvpqyatavlglrrkit..kdslpgar.pwvihcsagvg

ESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRA
 .| |. |  .  . | .. .|.|. || ..  || |    ||| | . |
rtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1191-1434 1.2e-29 98.1 In-house 3-235 (239) alignment 
Range on Protein: 1191-1434
Range on HMM: 3-235/239.0
AKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF---FDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSD--ETDWSDVEKYWPiDG
 |  |  ||||   | .|. ||.|        | |||||... |      |||.|  |.  .. |||||. ..    .|||.   |     . .||| | 
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei.ssgdfwrmmwqerrcvivmltglieghkkkchqywp.ds

SGTEChfgsernSVNVTCVSEEHHQDFIIRNLSYSMKDNesmPANQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLqrQSSLMGSQaPIVVHCRNGSSE
.   |        . ||    |   |.||| .  |   .     .. | || .| || |  ||. | ... |   .   . || |.. | |.||  |   
tskyc.......nlrvtlrktevfadyiirtfvmsqvgq...teeryvyqyhftvwp.dkgvpqyatavlglrrkit..kdslpgar.pwvihcsagvgr

SGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRA
.| |. |  .  . | .. .|.|. || ..  || |    ||| | . |
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_PTPRN_pd Subfamily PTPRN 828-970 2.7e-29 96.8 In-house 31-178 (297) alignment 
Range on Protein: 828-970
Range on HMM: 31-178/297.0
FAQEYESLPHFQLDTVAS---NRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKE-KKLFIAAQAPVDATIGDFWRMVWEQESYLIVM
...|.|.| ... .  ..   ....|. |||.... ..|..|||||. . .. |||||| .|      .  .||.|.|. .|. |||.||||| . .||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

VANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFS-FHSDYAIRAFDI
...|.|.. .||..|||||    |.   |.  |   .  || .|.| .
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfyl
subfamily_PTPN13_pd Subfamily PTPN13 997-1105 3.5e-29 96.9 In-house 159-266 (273) alignment 
Range on Protein: 997-1105
Range on HMM: 159-266/273.0
GQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQfNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQ
 . ...||.. . .|..| |.. |  .. ||.|. ..|.| . ...|.|.|||||.||.||.|.|| .|.    . . .. | | .||.||. .||. .|
dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdq

YVFIYKALA
|.|.|||. 
yifvykail
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1172-1439 4.1e-29 96.3 In-house 14-277 (287) alignment 
Range on Protein: 1172-1439
Range on HMM: 14-277/287.0
EEFKKLERNL-TTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTiGHADSSYINASHIKGYFFD--YIAAQDPVSeGTAFDFWRMIADQNVTTVVML
.|...| ..  ....    | .  .  ||||   .|.|. ||.|  . |.  |.|||| .. .|  |  .|||| |..  |  ||||.. ......|...
kevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPia.atvrdfwravletrsasvitm

SDETDWSDVE--KYWPIDgsGTECHFGseRNSVnvTCVS-EEHHQDFIIRNLSysMKDNESMPAnQEVVQYSYTGWPSDSIVPKsANSLMNLIEMV----
. | . .  .  ||||          |    ||  . .. .  . .. .| |   . | |.  | . | |. .  ||.... |  | .|. ..  |    
treveearlkcykywPer..evPmrvG..Gysv..vlldydikePeygvralr..lidletrea.rvvkqldllswPdkvlaPt.avglirfvldvkqhi

-LQRQSSLMGsqaPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
 |.|..| .|   |.|||.  |   |||.. .  |  | .   |.|| ..|  |. .|  .     |. . | ||. | 
elardasevG...PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1000-1119 4.4e-29 96.6 In-house 173-295 (297) alignment 
Range on Protein: 1000-1119
Range on HMM: 173-295/297.0
ANNSRRILQYHFTNWNDYKAPE--CSTGLLRFMYRLRELPQFNNS-PVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQ
| . | . ||.|..| | . ..    . || ..  .|.  . |.. |...||.||||||| ...|||.. .   |.. .||..|  ||..|  .||  ||
akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

YVFIYKALAEWHMYGDTDEDVRD
| |.|.|. |  .  ||. ..  
ykfvyvavleallsedtriqasy
subfamily_egg_pd Subfamily egg 837-1127 4.8e-29 96.0 In-house 29-287 (307) alignment 
Range on Protein: 837-1127
Range on HMM: 29-287/307.0
HFQLDTVASNrkENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKnrQQCA
.  | | ||.  .|  | | . ..  | .||||.  .|    |.| || .|       || ||||.  |  ||||||...|   |||..   |   ..| 
eislttaasd..nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

KYWPDEQ--ITR--YGDIIVEPASFSFHSDyaiRAFDIAHIGECGPDvipngngveyanvpivkgqfanNSRRILQYHFTNWNDYKAPECStglLRFMYR
 |||  .    .   | . .|      ..|     | ....   |.|                      .  | |..   ..|           || . .
yywpkaesdslvtvpGslrienlkvdskad...plfrvtklklvGgd......................deerflehwqgdvnnssdvysp...lrvlrk

LRELpqfnNSPVVIHCSAGVGRTGTFISIDSMLDQCLA--EDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAewHMYGDTDEDVRDFEDHYQRL
||.|      |||...  || ...|...|.  | . |     |  . . |  ||..|.| |.|  .|.|.|. ..   .. |    .....  |.| 
lrnl....skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl..fffrdvigsakeldvdyerw
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 995-1128 1.1e-28 95.3 In-house 169-308 (325) alignment 
Range on Protein: 995-1128
Range on HMM: 169-308/325.0
VKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELP---QF---NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRN
||.    ..| . |...  |.|   ..  . |. ..  . ..    .      .|...||||||||||.|||. |.|.. . | . .||.|| .||..| 
vkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrp

LMVQSLEQYVFIYKALAEWHMYGDTDEDVRDFEDHYQRLC
 ||.. .||..||.||.|  | |.||  |  || .   | 
smvetvdqyiliyealveaymsgntdvpvssfeaklsslq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 845-975 2e-28 94.2 In-house 3-133 (239) alignment 
Range on Protein: 845-975
Range on HMM: 3-133/239.0
SNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKE-KKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEq
.... |  |||| .| ..| .|| |.|.. | .||||||.... .    | .||.|  | .. ||||||.|..   .|||.. | |  ...| .||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

ITRYGDIIVEPASFSFHSDYAIRAFDIAHIGE
 ..| .. |        .|| ||.| ....|.
tskycnlrvtlrktevfadyiirtfvmsqvgq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 845-975 2.4e-28 93.9 In-house 2-132 (239) alignment 
Range on Protein: 845-975
Range on HMM: 2-132/239.0
SNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKE-KKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEq
.... |  |||| .| ..| .|| |.|.. | .||||||.... .    | .||.|  | .. ||||||.|..   .|||.. | |  ...| .||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

ITRYGDIIVEPASFSFHSDYAIRAFDIAHIGE
 ..| .. |        .|| ||.| ....|.
tskycnlrvtlrktevfadyiirtfvmsqvgq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1000-1143 5.1e-28 92.7 In-house 170-313 (439) alignment 
Range on Protein: 1000-1143
Range on HMM: 170-313/439.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF-NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYV
... | .||.|.. | | . |  .. .| |.  .    .  .  |||.||||||||||| |..|  |.|  .|.| .|   |  ||.||. |||.| |||
tekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyv

FIYKALAEWHMYGDTDEDVRDFEDHYQRlCASNRDRAVSFNQQSS
|||.|. |  .|||.   . .|. ...    | || ..  ...||
fiynavledivyGdiavtidefkkefna.gfstrdisifneedss
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 849-1109 5.8e-28 92.7 In-house 34-271 (285) alignment 
Range on Protein: 849-1109
Range on HMM: 34-271/285.0
ENAIKNRYNDIRAFDDTRVKLKKINgddySDYINANFIKS-WKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDeqitRY
 |   ||| |.|. ..||| ||. .     ||| |....   |..  .|..| |.  |. |||.|.....   ..|.. | |   ..|| |.|.    . 
anpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype....kl

GDIIvepaSfsFhSDYAIrafdiAhIGECGPDVIpngNGVEYANVPIVKGQFANNSRRIL-QYHFTNWNDYKAPECSTGLLRFmYRLRELPQFNNSPVVI
|...       |   | |     . . ||  . |    |  . .. ... . |..    . . .   | |  ||| .  .. . |.  .  . .. |...
gevv....k..f.gkyei.....t.lteckeeai...agtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel.ykwvkkvnpkekpicv

HCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHM
||||||||| ||. ||    . . . . .... | ..|  |   |||  |..|.|  | |. .
hcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_PTPN14_pd Subfamily PTPN14 830-945 8.4e-28 92.2 In-house 27-149 (300) alignment 
Range on Protein: 830-945
Range on HMM: 27-149/300.0
QEYESLPHFQLDTV--ASNRKENAIKNRYNDIRAFDDTRVKLKKINGDdYSDYINANFIKSW--KEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVA
.||| .|. ..|..  ... .||| |||..|.  ..|.||.|.  . .  ..||||  ||     ... .|.||.|.. |. |||.|||||. .||||..
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NLTEKNRQQCAKYWPDEQ----IT
. .|. .... ||.|...      
eeeedgkeksfkyfPkleskkktv
subfamily_PTPN13_pd Subfamily PTPN13 830-968 8.5e-28 92.4 In-house 15-155 (273) alignment 
Range on Protein: 830-968
Range on HMM: 15-155/273.0
QEYESLPHFQ--LDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGddysdYINANFIKSW--KEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVA
.|.. | ...  ...  ...|||  |||| ..  .|.|||||..  |     ||||..||    |..  .||.| |.  |. |||.|||||.. .|.||.
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NLTEKNRQQCAKYWPDEQ---ITRYGDIIVEPASFSFHSDYAIRAF
.  ||.. .| .|||...   .. .. . ||      ......||.
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvral
0036282 (Phosphotyrosine protein) phosphatases II 1223-1432 8.8e-28 92.6 In-house 2-163 (174) alignment 
Range on Protein: 1223-1432
Range on HMM: 2-163/174.0
SSYINASHIKGYFFD--YIAAQDPVSegtafdFWRMIADQNVTTVVMLSDETDWS--DVEKYWPIdgsgtechfgsernsvnvtcvseehhqdfiirnls
|.|||||.....     .|| | | .      ||.|. ....|||||| .|  .    .  |||                                    
sdyinaspldlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe...................................

ysmkdnE--SmpANQEVVQYSYTGWPSDSIVPKSAnsLMNLIEMVLQRQSSlmGSQAPIVVHCRNGSSESGIFICISLLWLRQKaEQRIDVFQTVKGLQS
         .    ....|| |..|| ..  . |   | .... | . .|.  ... |..|||. | . .|..... |.  ... |  .|....|. | .
......lred..lerlgiqylylpwpDhgvpdlsi..llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRl

HRPMMFTRFEQYSFCY
.||.|.....|| |.|
qrpgmvqtpsQyrfly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 853-1125 1.1e-27 91.5 In-house 46-297 (312) alignment 
Range on Protein: 853-1125
Range on HMM: 46-297/312.0
KNRYNDIRAFDDTRVKLkkiNGDDySDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDeqitrygdiIV
 ||| .|. .|  |  |    ||.   || |||.|     . |...|.|.. |.  ||...    |  |.... . |   ..||||  |         ||
lnrypniqcwdrgrftl...agde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd.........iv

EPASFSFHSDYAIRAFDIaHIGECGPDVIPNgnGVeyANVpIVKGqfANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRElpqfNNSPVVIHCSAGV
    .  |  |.    .|  ||    | |     |   .| .||   . .  .. .| .. | |.  |.     ||..  ..     .. ||. ||||||
gfvdledhrvyteyctei.eiggkskdkith..rv..lkv.vvka..tgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagv

GRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWH----MYGDTDEDVRDFEDHYQ
|||||.. |.||.       | |. .    ||..|   |. . |||.  ... |.     .|   ...   |.. | 
grtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketya
0044763 (Phosphotyrosine protein) phosphatases II 1206-1434 5.7e-27 89.9 In-house 1-166 (178) alignment 
Range on Protein: 1206-1434
Range on HMM: 1-166/178.0
PFDKYRVILPPTIGHADSSYINASHIKGYffDYIAAQDPvsegtaFDFWRMIADQNVTTVVMLSDETDW--SDVEKYWPIDGSgtechfgsernsvnvtc
|.| .||.|..  |.  | |||||.| ..   |.... |       |..... ....|..|.|..|. .   .  .||| . .                 
pldrtrvllsnleglersdyinaseilpg..lylgslpp......addlellkelgithivnlteelelgflkcdpywpeeag.................

vseehhqdfiirnlsysmkdnesmpanqevVQYSYTGWPSDSiVPKSANSLMNLIEMVLQRQSslmGSQAPIVVHCRNGSSESGIFICISLLWLRqkaeq
                              .|| ....| .. || .   .....|.. . ..    .. |..|||. | . || .... |.. .     
..............................iqylhipipDhg.vpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkkl.....

RIDVFQTVKGLQSHRPmMFTRFEQYSFCYRA
...... .. ....|| ......|. ..|. 
glsleeaielvrerRp.ivpnpgqlrqLyef
0043147 (Phosphotyrosine protein) phosphatases II 1222-1432 1.4e-26 88.7 In-house 4-154 (172) alignment 
Range on Protein: 1222-1432
Range on HMM: 4-154/172.0
DSSYINASHIKGYFF--DYIAAQDPvSEGTAFDFWRMIADQNVTTVVMLSDEtdwsdvekywpidgsgtechfgsernsvnvtcvseehhqdfiirnlsy
.| |||||....|.   ..|| | |    |  |||||. ....|..|.| ..                                                
gsdyinasyldlyyipdrfiatqgp.lrntladfwrmlkelgithivnltel................................................

smkDNESMPANQEVVQYSYTGWPsDSIVPkSANSLMNLIEMVLQRQssLMGSQAPIVVHCRNGSSESGIFICISLLWlrqkaeQRIDVFQTVKGLQSHRP
    .   .  ....|| |..|| |  || ... |....| . ...  .  .. |..|||. | . .| .... |..      ........|. ....||
...lydpellerlgiqylylpwp.Dhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRp

MMFTRFEQYSFCY
.... ..|| |.|
gavqnpsqyrfly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 853-1100 3e-26 86.9 In-house 53-273 (301) alignment 
Range on Protein: 853-1100
Range on HMM: 53-273/301.0
KNRYNDIRAFDDTRVKLKKiNGDDYsdYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQItrygdiiv
|.||. .    .| |.. . .|      | ||.|..  . . |||.|.|...|  ||| |.   .   |||...  ||. ..|..| | .          
khryptvPckPstaveviv.dGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis........

epasfsfhSDYAIRAFDIAHIGEcgpDVIPNGNgVEYANVPIVKGQFANNSRRILQYHFTNWNDYKAPECSTGllrfMYRLRELPQFNNSPVVIHCSAGV
        ..  |  |.|    .   ..| | . .   .. ..      ..| .. | ...| |.  |.  .     .. | || .  . |.|.|||||.
........ekldigrfkikiknk...elilnkk.iskrtlevedstgkfatrtvthyqysewtdrgvPkshae....lfdlmelvkksekPivvhcsaGi

GRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFI
||. .||. . .  . .|. . .. | . .|| .|   ||  .|  ..
Grsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
0046846 (Phosphotyrosine protein) phosphatases II 1215-1438 6.5e-26 86.6 In-house 4-172 (176) alignment 
Range on Protein: 1215-1438
Range on HMM: 4-172/176.0
PPTIGHADSSYINASHIKGYFfdYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETDWSDV--EKYWPIdgsG----Techfgsernsvnvtcvseeh
 ...   |..||||. | |..  .|| | |. . |  ||..|. ....|.||.| .|.. . .    |||.                             
rllgldldldyinanlilgsr..piatqgplpr.tladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi....................

hqdfiirnlsysmkdnesmpanqevvQYSYTGWPSDSIVPKsaNSLMNLIEMVLQRQSSlmGsqAPIVVHCRNGSSESGIFICISLLWLrqkaEQRIDVF
                          || ...||  .. .   . |..|.|.. .....  |   |..|||. | . .| .... ||.|    |. ..|.
..........................qylhlpwpDhgvpdl..elllellefirealke..g..gpvlVHCsaGigRtgtlvaayllel....ekglsve

QTVKGLQSHRP-MMFTRFEQYSFCYRALADY
.... ....|| .... .||| |.|...  .
ealalvreqRplgavqtpeQyrflyefelll
PTPc_DSPc_SM00012 1333-1436 9.2e-26 85.5 In-house 2-104 (105) alignment 
Range on Protein: 1333-1436
Range on HMM: 2-104/105.0
VVQYSYTGWPSDsIVPKSANSLMNLIEMVLQRQSSLMGsQAPIVVHCRNGSSESGIFICISLLWLRQKAE-QRIDVFQTVKGLQSHRPMMFTRFEQYSFC
| .| |||||    ||....|...|.. | . ..     ..|.||||..| . .|.|.....|. . ..| ...|.||.|| | ..|| |....|||.|.
vkhyhytgwpdh.gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YRALA
||||.
yrall
subfamily_ptpA1_pd Subfamily ptpA1 1170-1392 1.3e-25 85.0 In-house 23-249 (418) alignment 
Range on Protein: 1170-1392
Range on HMM: 23-249/418.0
LEEEFKKLERNLTtPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKG-YFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVML
..|||. || ..  |  ..   |  |  ||||   .| .. || |     .  | |||| .| | |  ..|..| |. . |  |||||. .. .  .|||
ikeefrlleesvg.psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpn.tiadfwrmvwenrcriivml

SDETDWSD--VEKYWPIDGSGTECHFGSER------NSVNVTCVSEEHHQDFIIRNLSYSMKDNesmpaNQEVVQYSYTGWPSDSiVPKSANSLMNLIEM
| |..     ...||| .  | .     .        ||..  | ..  .. | ||.  ... .      ... || | |||    .|  .. . .|.  
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfege.....trditqyqyegwpdhn.ipdhtqpfrqllhs

VLQRQSSLMGS---QAPIVVHCRNGSSESGIFICI
. .||  .. |   . ||.|||  |   .| |   
itnrqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_PTPN3_pd Subfamily PTPN3 995-1105 2.1e-25 84.2 In-house 162-272 (280) alignment 
Range on Protein: 995-1105
Range on HMM: 162-272/280.0
VKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSL
.| . ....|.|||  ...| | . |. |. .|.|. |.|.| . ...|||.|||||.|||| .| ..  |    |... .. . | ..| ||  .||. 
lkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta

EQYVFIYKALA
.|| |. .|. 
sqykfvCeail
subfamily_PTPN9_pd Subfamily PTPN9 1000-1110 2.2e-25 84.3 In-house 169-292 (297) alignment 
Range on Protein: 1000-1110
Range on HMM: 169-292/297.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELP-------------QFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQ
 ..||..  . |. | ||  |. .. || ..   ||               . .. |.|.|||||.|||||||..|  |..   .......| |  || |
teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

RNLMVQSLEQYVFIYKALAEWHMY
|  ..|  |||.| |.|. |. ..
rafsiqtpeqyefcylavleyale
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1161-1443 4.4e-25 83.3 In-house 9-281 (307) alignment 
Range on Protein: 1161-1443
Range on HMM: 9-281/307.0
MTTSNGETGLEEEFKKLERNltTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILppTIGHADSSYINASHIKG--YFFDYIAAQDPVsEGTAFDFWRMIA
 |   | . | .||..| .   || . .  | . |  ||||.     || |...  ..  . | || | ..        .|.|| |  | | ..|| |. 
rtldkgvqalvdefrvlakk..tpegvtveafsantdknryqdvkcqdkgrivv..kfdglasdyihanylgiaikpkkficaqgpl.entqysfwamai

DQNVTTVVMLSD--ETDWSDVEKYWPIDgSGTECHFGSERNSVNVTCVSEEH--HQDFIIRNLSYSMKDNEsmpANQEVVQYSYTGWPsDSIVPKSANSL
...| .|.|| .  |.    .|.|||..  | .  ||.. |...|. .  ..   .. .|   .  ..  .    .. . .. .. || |  ||.   . 
qekvesvimlckvielakikceqywple.egqklvfgeapntisvanlgakklapdedlinvttlkvdwaq...ksrtiqhlqwenwp.drgvpqinlta

MNLIEMVlqrqsslMGSQAPIVVHCRNGSSESGIFICISLLWLRQ-KAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKTY
.||.| |        . . |.||||  |   ||  ..|||.  .  . .   |. . |. |.|.|.       || . .| | .|  . |
inlleav.......rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflely
0051082 (Phosphotyrosine protein) phosphatases II 1223-1434 1.1e-24 82.1 In-house 3-148 (151) alignment 
Range on Protein: 1223-1434
Range on HMM: 3-148/151.0
SSYINASHIKGYffdYIAAQDPVSegtafDFWRMIADQNVTTVVMLSDETDWSDVEKYWPIDGsgtechfgsernsvnvtcvseehhqdfiirnlsysmk
|.|||.| . |.   ... . | .     ||..........|.|.| .|. .    .|.|  |                                     
sdyinfsyvtgg...lyrsggpla.....dflellkelgiktivnlrseeergycpeylpelg.....................................

dnesmpanQEVVQYSYTGWPSDSiVPKSANSLMNLIEMVLQrqsslmGSQAPIVVHCRNGSSESGIFICISLLWLRqkaeqrIDVFQTVKGLQSHRPMMF
         ||... ...||  . .| | .......|..|.       .. |..|||. | . .|..... |. |.      ........ ....||...
........ievlhipildwpdpg.lplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvv

TRFEQYSFCYRA
. ..|. |...|
qpnqqflfqlfa
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 998-1108 1.7e-24 81.3 In-house 167-278 (287) alignment 
Range on Protein: 998-1108
Range on HMM: 167-278/287.0
QFANNSRRILQYHFTNWNDYK-APECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQ
. |.. ... ||..|||..    .|  | || .  . ..  .  |...|.|||..|||...|....  ...|  |   ..|. . . | |.  .||  ||
nkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq

YVFIYKALAEWH
| ||.... |  
ykfindivleyl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1002-1105 1.8e-24 81.2 In-house 134-237 (239) alignment 
Range on Protein: 1002-1105
Range on HMM: 134-237/239.0
NSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIY
. | . ||||| | |   |. .| .| .  .. .       | ||||||||||||.|. ||.|| |.  .   .||..|  .| .|  |||. ||||||.
eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

KALA
 |. 
lavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1002-1105 2.2e-24 81.0 In-house 135-238 (239) alignment 
Range on Protein: 1002-1105
Range on HMM: 135-238/239.0
NSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIY
. | . ||||| | |   |. .| .| .  .. .       | ||||||||||||.|. ||.|| |.  .   .||..|  .| .|  |||. ||||||.
eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

KALA
 |. 
lavl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 828-942 2.6e-23 77.1 In-house 13-130 (281) alignment 
Range on Protein: 828-942
Range on HMM: 13-130/281.0
FAQEYESLPHF---QLDTvASNRKENAIKNRYNDIRAFDDTRVKLKK-INGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVM
| ||.  ||     .| | . |.  |  |||| .| ..| .||.||  .   . .||| ||.|.|   |. .| .| |   |  |||||.|....  |||
fkqefsnlpgdppsdlct.vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

VANLTEKNRQQCAKYWPDE
.....| ||..||.|.| .
lcqfletnrekcaeyfprn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1000-1108 3.2e-23 77.1 In-house 151-259 (267) alignment 
Range on Protein: 1000-1108
Range on HMM: 151-259/267.0
ANNS-RRILQYHFTNWNDYKAPECstgLLRFMYRLRELP--QFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQ
 |.| . .  |.. .||     .     |. .. .      .  | |.|..||.||||.|||. |||.|..   |. ..||.|. ..| ||  .|...|.
knesahnvtlyyykkwnintnnkp...ylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtker

YVFIYKALAEWH
|..|.. |||. 
yiyihellaeya
0049260 (Phosphotyrosine protein) phosphatases II 1246-1432 7.5e-23 76.3 In-house 18-143 (152) alignment 
Range on Protein: 1246-1432
Range on HMM: 18-143/152.0
SEGTAFDFWRMIADQNVTTVVMLSDETDWSD--VEKYWpidgsgtechfgsernsvnvtcvseehhqdfiirnlsysmkdnesmpanqevvQYSYTGWPS
 . |. |||||. ....||.||| ....     .|.|.                                                     || .. || 
gpntladfwrmlkelgittivmltellelgklkceqyi.....................................................qylhlpwpD

DSiVPKSANSLMNLIEMVLQRqssLMGSQAPIVVHCRNGSSESGIFICISLLWlrqkaeQRIDVFQTVKGLQSHRPMMFTRFEQYSFCY
.. ||...  |. |.... ..   .  .. |..|||. | . .| .... |..      ........|. ....||.... ..|. |.|
hg.vpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_CG42327_pd Subfamily CG42327 829-965 1e-22 75.3 In-house 8-148 (319) alignment 
Range on Protein: 829-965
Range on HMM: 8-148/319.0
AQEYESLPhfQLDTVASN-RKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEK-KLFIAAQAPVDATIGDFWRMVWEQESYLIVMVAN
|.|.. ||  || . | .       |.|. ..  . .||| |..|  || . |..|....  ..    .||||.. . .  ||||.|||| |  || ...
aeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LTEKNRQQCAKYWPDEQ----ITRYGDIIVEPASFSFHSDYAI
| |.  ..||.|.| ..       |||| |       .  |||
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryai
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1182-1419 1e-22 75.1 In-house 43-263 (290) alignment 
Range on Protein: 1182-1419
Range on HMM: 43-263/290.0
TTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPtiGhADSSYINASHIKGYFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSD--ETDWSDVEK
. .|  .   |. .. ||||   |  || ||||    |  |  |. | ..||    .| .| .. . |..|.|||. ...|...||| .  |   .  |.
vqylerkifdkntefkknrykdvvcndktrvilkd..G.ydGdyvhanyvkGlkamfiltqGalkd.tvidiwrmvlqekvaaivmlceliedGkakceq

YWPiDGSGTECHFGSernsVNVTCVSEEHHQDFIIRNlSYSMKDNESMpANQEVVQYSYTGWPSDSIvpksANSLMNLIEMVlqrqSSLMGSQAPIVVHC
|.| . .|    ||.    . |.|  |..... ||..   |..| .|   .  .  .    ||  |.    |.| . |. ..     .|     |.||||
yyp.ekeGevltfGe....itvlcseeddkdaniikk.tlsvrdkdsG.kehklkhlkikswpdksv....alstlallrtl....rilrkasGpvvvhc

RNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRP
  |   .| |. |          . .|. ..|. |.  | 
saGiGrtGtfvaievglqilldGkeldlldlvralrnsrl
0048076 (Phosphotyrosine protein) phosphatases II 1001-1105 1.4e-22 75.4 In-house 42-140 (145) alignment 
Range on Protein: 1001-1105
Range on HMM: 42-140/145.0
NNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQfNNSPVVIHCSAGVGRTGTFISIDSMLDqclaeDKANIFEFVCNLRRQRNLMVQSLEQYVFI
. .| ..||....| |. .|. .  ||.|.  ..|. . .. ||..|||||||||||.. .. ||       . ...| .  .|.||  .|.. .|. |.
llerlgiqylylpwpDhgvpdllellleflefieealk.eggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfl

YKALA
|... 
yefel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1001-1107 1.5e-22 74.8 In-house 149-263 (270) alignment 
Range on Protein: 1001-1107
Range on HMM: 149-263/270.0
NNSRRILQYHFTNWNDYKAPECST------GLLRFMYRLRELPQ-FNN-SPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQ
 ..||.. .....|.|  .|. .        ||. .  .|.  . ... .|...|||||||||||.| .| ..     . |... . . .||..|  .||
geerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvq

SLEQYVFIYKALAEW
  ||| |.|||..|.
hpeqyeflykavvey
0048179 (Phosphotyrosine protein) phosphatases II 996-1102 3.1e-22 74.3 In-house 48-139 (144) alignment 
Range on Protein: 996-1102
Range on HMM: 48-139/144.0
KgqfannsrrILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQfNNSPVVIHCSAGVGRTGTFISIDSMLdqclaEDKANIFEFVCNLRRQRNLMVQSLE
          ..||....| |. .|. .. ||.|.  ..|. . .. ||..|||||||||||.. .. |.     . . ...| .  .|..|  .|.. .
e.........giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg

QYVFIYK
|. |...
qlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 998-1132 6.4e-22 72.5 In-house 81-218 (440) alignment 
Range on Protein: 998-1132
Range on HMM: 81-218/440.0
QFAN--NSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELP-QFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSL
 . |  .|| . |||.  | |   |. .  .|...  . |   .  |.|...|||||.||||  |..||.| ..   |. .|| |. ..| .|  |||. 
syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

EQYVFIYKALAEWHMYGDTDEDVRDFEDHYQRLCASNR
|||.|...|. |  . |||     |  .. ...   | 
eqyafvheavlegllcgdtliledditerveqiqwpnp
subfamily_PTPN14_pd Subfamily PTPN14 1000-1106 2.4e-21 71.0 In-house 179-294 (300) alignment 
Range on Protein: 1000-1106
Range on HMM: 179-294/300.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQF---------NNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLM
... | ..   .|.| | . ||  .| | .. ... . .          .. ||..||||||||||  |  | ..     ... .| . .  ||.|| |.
skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmll

VQSLEQYVFIYKALAE
||.| || |.||.| .
vqtlaqYkfvYkvlik
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 848-952 8.3e-21 68.9 In-house 54-155 (290) alignment 
Range on Protein: 848-952
Range on HMM: 54-155/290.0
KENAIKNRYNDIRAFDDTRVKLKkiNGDDySDYINANFIKSWkeKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDE--QIT
  .  |||| |.   | ||| ||  .| |  ||. ||..|    |  || .| .. .|. |.|||| ...   |||. .| |. . .|..|.|..  .. 
ntefkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl

RYGDIIV
 .|.| |
tfGeitv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1232-1421 3.5e-20 66.9 In-house 86-263 (301) alignment 
Range on Protein: 1232-1421
Range on HMM: 86-263/301.0
KGYFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETD--WSDVEKYWPIDGSgteCHFGSERNSVNVTCVSEEHHQDFIIRnlSYSMKDNESMPA
.|    .||.| |... |. ||| |.   .| ..|||. . .   .  |.| |.. |    ..  .| .....      ... . |  .  ..|     |
sGhphrfiatqgPlkn.tsedfwamlvqydvekivmlgqkvekleekceeylpvkis...ekldigrfkikiknkelilnkkiskr..tlevedstgkfa

NQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQrqsslmgSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMM
 . |. | |. |. |  ||||   |..|.|.| .       |. |||||| .|   |  ||    |  . .|...|.. ...| |. ||   
trtvthyqysewt.drgvPkshaelfdlmelvkk.......sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwng
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 827-972 4.9e-20 66.7 In-house 7-150 (267) alignment 
Range on Protein: 827-972
Range on HMM: 7-150/267.0
LFAQEYESLPHFQLDTVA---SNRKENAIKNRYNDIRAFDDTRVKLKKINGDdysdYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVM
 . .|.| . .   ..     |  ..|. .||..|   .||||| |.. . .    |||| .....| |. ||. | |.. ||.||. .. .|.   ||.
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

VANLTEKNRQQcakYWPDE--QITRYGDIIVEPASFSFHSDYAIRAFDIAH
. .  . | ..   .|| .  |  .| |. || .      || | ....  
ltkvftdnirl...fwPPkmgqakkyqdltvehslekeendyqiitlelkf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1189-1435 2.6e-19 64.2 In-house 27-291 (297) alignment 
Range on Protein: 1189-1435
Range on HMM: 27-291/297.0
FAAKDENLLKNRYEAAVPFDKYRVILPPTIghADSSYINASHIK----GYFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLS--DETDWSDVEKYWP
 | ..  | ||||   . .|. || |  .|  ... |||| ..        . || || |.|. |  |||...|.|.| ..||..   |   .    |||
sakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsa.tvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

IDGSGTecHFGSERNSVNVTCVSEEhHQDFIIRNLSYSMKdNESmpanQEVVQYSYTGWPsDSIVP-------K----------SANSLMNLIE----MV
    .      ..     .. .|.| ..  |. .|    . .||    . |    . .|| |  ||       .          .   .. |.|    ||
svvqer..lkagdvvveflsstsde.fdrviltelqliyr.ses....rvvrhvqflswp.dhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

LQRQSS---LMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRAL
. .  |    |  .|...|||  |   ||. .    .  . . ..  ||   .. |.. |...   .||. ..| | 
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1198-1431 1.2e-18 62.3 In-house 22-251 (290) alignment 
Range on Protein: 1198-1431
Range on HMM: 22-251/290.0
KNRYEAAVpFDKYRVILPPTIGHADSSYINASHIKG-YFFDYIAAQDPVSEG------TAFDFWRMIADQNVTTVVMLSDETD----WSD--VEKYWPiD
..|.| .. . . ||.|     .  . || |....       |. | |  .       | ..|| |. . .|. |||| . ..    .|.   .|| | .
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp.e

GSGTECHFgserNSVNVTCVSEEHHQDFIIRNLSYSMKDNESMpanqEVVQYSYTGWpSDSIVPKSANSLMNLIEMVlqrqsslMGSQAPIVVHCRNGSS
  |.|  |    . ..| | | |...|...|.|     |.| .     |  . . || ... |...  .|..||..|       . |..|..||| .| |
svgeelkf....kgltvkCkskekeddvetRelvvkfddeeef....tvtHsllkgW.nklnvqedtktllsliqkv.......kasktpvivHcvdGiS

ESGIFICISLLWLRQK-AEQRIDVFQTVKGLQSHRPMMFTRFEQYSFC
 | ..  | | .      .. . . . .| |...| ...|. ....| 
rsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafv
subfamily_PTPRN_pd Subfamily PTPRN 1000-1106 1.3e-18 61.8 In-house 183-290 (297) alignment 
Range on Protein: 1000-1106
Range on HMM: 183-290/297.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAED-KANIFEFVCNLRRQRNLMVQSLEQYV
....| . |.||  |..  .|  .  || |  ..    .   .|.|.|||.|.||||..| || .|.. |    . .|   .  || ||. .|.. .|. 
tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfe

FIYKALAE
|...|.||
faltavae
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 849-955 2.3e-18 60.9 In-house 54-161 (305) alignment 
Range on Protein: 849-955
Range on HMM: 54-161/305.0
ENAIKNRYNDIRAFDDTRVKLKKINgddYSDYINANFIKSW-KEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPD---EQI
 .  ||||.|. . | . |||.| .    |||| ||..      .| ||.|| |.| || .|| || ..    |||...  |  . .||.|||    |. 
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

TRYGDIIVEPA
.  . |.||  
elksgivvenv
subfamily_eak_pd Subfamily eak 845-1122 1.1e-17 58.4 In-house 47-317 (332) alignment 
Range on Protein: 845-1122
Range on HMM: 47-317/332.0
SNRKENAIKNrYNDIRAFDDTRVKLKKINGdDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQ-
..| |.  .|   .|  .|   |.|      .   ||||  ..  .  . .| . .. .  .  ||.|| || |  ||....  |.. ..  ||.||.  
tarleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

-ITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDVIPNGNGVEYANVPIVKGQFANnSRRILQYHFTNWNDYKapecSTGLLRFMYRLRELPQfNNS
   ..| . ||  .|  .. .  | . .    |       .  |    ..|...  .|   . . .    .    |    |. |  .. .    |   ..
eelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflal.rkvmkevGvlllivmk....sallsstlkkyihtpp.sfa

PvVIHCSAGVGRTGTFISIDSMLdQCLAEDKAN---IFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMygDTDEDVRDFED
| .| .. |  |.|.|. || .. . . . | |   . ...   . .|.  |    |. |||... .. .    .. .||...
p.iiqsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll..rrnnrlrdlkk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1170-1443 3.4e-17 57.0 In-house 26-293 (305) alignment 
Range on Protein: 1170-1443
Range on HMM: 26-293/305.0
LEEEFKKLERNLTTPL----SSNFAAKDENLLKNRYEAAVPFDKYRVIL--PPTIGHADSSYINASHIKGYffDYIAAQDPVSEgTAFDFWRMIADQNVT
| |||..| .     .         . | .  ||||.     |.  | |  |.   .  . |. .  |      .|.|| |. . |  .|| |. ...| 
lreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipek..rficaqgpldq.tidefwwmviqnkve

TVVMLSDE--TDWSDVEKYWPID-GSGTECHFGSERNSVNVTCVsEEHHQDFIIRNLSYSMKDNESMpanqEVVQYSYTGWPSDSIVPKSANSLmNLIem
 .|||     .    . .|||.  |   | . |   . |  .    |   .  |  |  ..  ...|     | .  .| ||   . |    || .|.  
qivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskp.merdaeiqitllnltysgdqkm....svrhlqwtewpdrgvppckltsl.ell..

vlqrqSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRqKAEQ--RIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKTY
     |.. ||. ||||||  |   .|  ..|  .  .  ||.     . . || |. .| .      || | .| . .|. . |
.....sairgskvpivvhcsagigrtgtivaieyilek.iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
subfamily_egg_pd Subfamily egg 1179-1438 1.1e-16 55.4 In-house 24-269 (307) alignment 
Range on Protein: 1179-1438
Range on HMM: 24-269/307.0
RNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKG--YFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETDWSD
 ...   | . ||.|.|| | | .     |  || |    |     .| | ..||   . ..| || |. . |  |||||.  ..|  .|||.   .   
eesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkn.tvddfwrmvfqeevqyivmltsrkeser

VEKYWPIDGSGTECHFgseRNSVNVTCVSEEHHQDFIIRNLSYSM--KDnesmpanQEVVQysYTGWPSDsiVPKSANSLMNLIEMVLQRQSSlmgsqAP
 | |||   | .         |......  ... | . |     .   |       .|        |  |  | .|..  . |  . . |. |      |
ceyywpkaesdslvtv...pGslrienlkvdskadplfrvtklklvGgd.......deerf..lehwqgd..vnnssdvysplrvlrklrnls.....kp

IVVHCRNGSSESGIFICI--SLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADY
.||.. .| | .. ...|  .|| | .    .  | ..|. |. .|..      .| | || .. .
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1161-1439 1.4e-16 55.4 In-house 12-271 (288) alignment 
Range on Protein: 1161-1439
Range on HMM: 12-271/288.0
MTTSNGETGLEEEFKKLERNLTTPLSSNFAAkdeNLLKNRYEAAVPFDKYRVILPptighADSSYINASHIK---GYFFDYIAAQDPVsEGTAFDFWRMI
.  ...  ||. |..    . .    ..| |   |  ..|||     |  || |       |. .  |...     |    | || |. .||   .|.|.
lvlqiaveglkkeyrdspneasidiidsfia...nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPl.ngtieelWkml

ADQNVTTVVMLSD--ETDWSDVEKYWPIDgSGTECHFGSErnsvnvtCVSEEHHQDFIIRNLSYSMKDNESMPANQE-VVQYSYTGWPSDSiVPKSANSL
 ...|  .|||..  |      ..|.|    | . ..|         |    .... | . .. |.  ..    ..  | .  .  |. |. ||..  | 
lesdveyivmlcellekGkeksaeyfPsk.lGekarigrl.......ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddg.vPenylsp

MNLIEMVlqrqsslMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
..|.|..          | |||||...|.  .| .| | .     . .  . . . .. |. .|    .   || . .| . ...
lrllevl.......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1237-1433 1.5e-16 55.1 In-house 6-198 (199) alignment 
Range on Protein: 1237-1433
Range on HMM: 6-198/199.0
DYIAAQDPVSEGTAfDFWRMIADQNVTTVVMLSDETDWS--DVEKYWPIDGSGTEcHFGsernSVNVTCVSEEHHQDFIIRNLSYSmKDNESMPANQEVV
 |||.| |. |  | |||.|. .     .||. |.      |   |||   |||  ..|    |..||. .   . |. |  |  . ..  . |. .|. 
ryiatqhplretma.dfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kyg....slsvttktittkpdytitalilt.nnttappstreis

QYSYTGWPSdSIVPKSANSLMNLiemVLQRQSSL---MGSQAPIVVHCRNGSSESGIFICISLlWLRQKAEQR---IDVFQTVKGLQSHRPMMFTRFEQY
.| .| |      |. |  .  .   |  |. |       .||..||| .|   .|.|... .  .| . | .   .|.|.  | |.  |  . . ...|
hyqftswke.kttpnvalfvgfv...vasrevskkyeqekdapvivhcsdgqgftgvfvaldi.gvrsheesktsvvdlfevakrlrqarcgiisslqhy

SFCYR
 | |.
nfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1237-1433 1.5e-16 55.2 In-house 5-197 (198) alignment 
Range on Protein: 1237-1433
Range on HMM: 5-197/198.0
DYIAAQDPVSEGTAfDFWRMIADQNVTTVVMLSDETDWS--DVEKYWPIDGSGTEcHFGsernSVNVTCVSEEHHQDFIIRNLSYSmKDNESMPANQEVV
 |||.| |. |  | |||.|. .     .||. |.      |   |||   |||  ..|    |..||. .   . |. |  |  . ..  . |. .|. 
ryiatqhplretla.dfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kyg....slsvttktittkpdytitalilt.nnttappstreis

QYSYTGWPSdSIVPKSANSLMNLiemVLQRQSSL---MGSQAPIVVHCRNGSSESGIFICISLlWLRQKAEQR---IDVFQTVKGLQSHRPMMFTRFEQY
.| .| |      |. |  .  .   |  |. |       .||..||| .|   .|.|... .  .| . | .   .|.|.  | |.  |  . . ...|
hyqftswke.kttpnvalfvgfv...vasrevskkyeqekdapvivhcsdgqgftgvfvaldi.gvrsheesktsvvdlfevakrlrqarcgiisslqhy

SFCYR
 | |.
nfiyq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1002-1106 2.5e-16 54.2 In-house 181-281 (290) alignment 
Range on Protein: 1002-1106
Range on HMM: 181-281/290.0
NSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPqfnnSPVVIHCSAGVGRTGTFISIDSMLdQCLAEDKA-NIFEFVCNLRRQRNLMVQSLEQYVFI
 . ..  ..   | |   .  .  ||| .. ||...     |||.|||||.||||||..|.  | |.| . |. .. . |  ||. |   ||   ||. .
kehklkhlkikswpdksvalstlallrtlrilrkas....GpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylal

YKALAE
 ..| .
veilld
subfamily_PTPN23_pd Subfamily PTPN23 1000-1104 3.6e-16 53.8 In-house 167-276 (288) alignment 
Range on Protein: 1000-1104
Range on HMM: 167-276/288.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRE----LPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDK-ANIFEFVCNLRRQRNLMVQSL
|.. . .   ..|.| .. .|.    ||.|.   ..      .  . |.|.||||||||||.|  . . . .  ...  ..| . |  ||.||  |||  
adavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqek

EQYVFIYKAL
||. | |.| 
eqlkfsyeav
0048179 (Phosphotyrosine protein) phosphatases II 1257-1433 4.8e-16 54.3 In-house 25-139 (144) alignment 
Range on Protein: 1257-1433
Range on HMM: 25-139/144.0
IADQNVTTVVMLSDETDWSDVEKYwpidgsgtechfgsernsvnvtcvseehhqdfiirnlsysmkdnesmpanqeVVQYSYTGWPsDSIVPKSANSLMN
......|||. |..| .. ..|..                                                    ..|| ...|| |  || ... | .
lkklgittvinlteeyepeflere....................................................giqylhlpwp.Dhgvpdllellle

LIEMVLQRQSslmgSQAPIVVHCRNGSSESGIFICISLLWlrqkaEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYR
..|.. . ..    .  |..|||. | . .| .... |..     ........... ..|.||.... ..|. |...
flefieeale....eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 1312-1435 5.5e-16 54.0 In-house 31-139 (145) alignment 
Range on Protein: 1312-1435
Range on HMM: 31-139/145.0
FIIRNLsY-SMKDNEsmpanQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQSSlmgsQAPIVVHCRNGSSESGIFICISLLWLrqkaeQRIDVFQT
  . ||     .. |     ....|| |..|| |  || ... |....|.. . ...      |..|||. | . .| .... |..|     ........
ttvlnl.tselelle.....rlgiqylylpwp.Dhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleea

VKGLQSHRPMMFTRFEQYSFCYRAL
.. ..|.||.......|. |.|...
lelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 898-1101 7.8e-16 52.4 In-house 96-281 (302) alignment 
Range on Protein: 898-1101
Range on HMM: 96-281/302.0
AQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEqitrygdiIVEPasFSFhSDYAIRAFDIAH-IGECGPDVIPNGNGVEYANVPIVK
   |   |.  .| .. . .  ..| .... |.. ..||.|. |.        . .   . |   |.... .. . . |       .   ||. |    |
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdk........vgge..lkf.grytvktvsvktdleeftdkksfklytveiknekkkk

gqFANNSRRILqyHFTNWNDYKAPECSTGLLRFMyRLRElpQFNNSpVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQ
    . .  ||  .|. | |. ||. .   |  . .  |   . .. |..|||||||||||...|   .. |. .. ... . |. .|. |   ||. .|
..kvkktvdil..afsawpdhGapkeaytaldil.kfce..sykkn.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

YVFIY
 ... 
liyll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1196-1439 9.9e-16 52.4 In-house 48-344 (350) alignment 
Range on Protein: 1196-1439
Range on HMM: 48-344/350.0
LLKNRYEAAVPFDKYRVILP------PTIGH--ADSSYINASHIKGY--------FFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLS--DETDWSDV
  ||||.  .|... ||.|.       .. |    . ||||...|           | |||.| |. . |  ||...|   .|. ...|.  .| .   .
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlps.tvddfykvillnkvkvilsltsdvelnlekc

EKYWPIDGS-GTECHFGSERNSV----NVTCVSEEHHQDFI---IRNLSYSMKDNESMPA-------NQEVVQYSYTGWPSDS--IVPKSANSLMN----
..||.  .  .   .. | ....    ...  | . ....      .    .|||.|. |         .| |  .  |.  |  . |.|  . ..    
yrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevknd

LIEMVLQRQSSLMGSQAPIVVHCRNGSSESGIFICISLLWL-------RQKAEQRID--------VFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
||.    .. .    ..||.|||  |    |... .  |          .|  ...|        ....|. |.. |  |    .|. |.| ||  | 
liddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1184-1439 1.5e-15 51.9 In-house 24-270 (285) alignment 
Range on Protein: 1184-1439
Range on HMM: 24-270/285.0
PLSSNFAAKDENLLKNRYEAAVPFDKYRVILPptigHADSSYINASHIKGYF---FDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDET--DWSDVE
|    ..| . |   |||      .. ||.|       |  || || ..        ||..| |. | |  |||.|| ..... |.||          . 
ppnctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpe.tlsdfwhmiyqekiayvlmlctlfeggvekca

KYWPiDGSGTECHFGseRNSVNVTCVSEEHHQDFIIRNLSY-SMKDNESMPANQEVVQYSYtgWPsDSIVPKSANSLMNLIEMVLQrqssLMGSQAPIVV
 |.| .  |   .||  .  . .| . ||     |. .|.    .|  | |   . ||  .  || | . |. |  ...| . | .    .   . ||.|
lyyp.eklgevvkfg..kyeitlteckeeaiagtilnaltvintedasseplymnhvqvpw..wp.dqlapedarpmielykwvkk....vnpkekpicv

HCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
||  |   .  |. |    .|   .  |.... |. ... |      . |. | |  | .|.
hcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_CG42327_pd Subfamily CG42327 1197-1368 1.6e-15 51.6 In-house 30-194 (319) alignment 
Range on Protein: 1197-1368
Range on HMM: 30-194/319.0
LKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYF---FDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETDWS--DVEKYWPIDGSGTECh
 |.|.  .||. . ||.|.    .  . |..||...||      ||||| .  . .. ||||.. .|.  ..| |.|  .       .|.|   .. .  
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsled.sssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt.

fgSERNSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpaNQEVVQYSYtGWPsDSIVPKSANSLMnliEMVLQRQSSL
  |    . ||    | .. ..|  |     |.|     .|.  | |  |. .. || . ..|.    |.|. .|||
..slyGdilvtlkgrevkdryaistlllkrvdkee...srelthywy.kwl.eaevPaeeaali...amllevrssl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1165-1411 1.9e-15 51.2 In-house 24-262 (310) alignment 
Range on Protein: 1165-1411
Range on HMM: 24-262/310.0
NGETGLEEEFKKLERNLTTplSSNFAAKDENLLKNRYEAAVPFDKYRVILppTIGHA-DSSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQN
 |  ||  ...||. .  .  |  . |  ... ||||   |  |. || |  .| ..    || | ..|  ..   .| .| |.   |  |||||| .. 
lgieglvkqyrkldakqds..sltyeaykkymhknrysdvvcldtsrvkl..kidksryedyihanyvktnylrstficsqgplqh.tiidfwrmifqer

VTTVVMLSDETDWSDVE--KYWPIDGSgTEChFGsernSVNVTCVSEEhHQDFIIRNLSYSM-KDN---ESMPANQEVVQYSYTGWPS--DSIVPKSAns
  ....|   ..        |||  |  ||  .|     . || .||   ..| | ||. ..  ||   .  ||| . .. |   ||   |  ||     
aesilllckvgeegrpkcvgywpslgv.tet.yg....cirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek..

lmnlIEMVLQRQSSLMgSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTV
       | ||  . .  . | ||||  |    .. . . | . . .  ...|. . .
....chtvpqrllaqv.rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1006-1107 2.5e-15 50.9 In-house 190-288 (305) alignment 
Range on Protein: 1006-1107
Range on HMM: 190-288/305.0
ILQYHFTNWNDYKAPECSTGLLRFMYRLRElpqfNNSPVVIHCSAGVGRTGTFISIDSMLDQcLAEDKA--NIFEFVCNLRRQRNLMVQSLEQYVFIYKA
. . ..|.| |   | |    | ..  .|      . |.|.|||||.||||| ..|. .|.. .||.|    . |.|  || ||   .|.  ||.||.. 
vrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilek.iaenkpcppmpelvkalrdqrafsiqndvqylfihrv

LAEW
. ..
mlny
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1171-1437 5.4e-15 49.8 In-house 14-267 (281) alignment 
Range on Protein: 1171-1437
Range on HMM: 14-267/281.0
EEEFKKLERNLTTPLSSNFAAKdENLLKNRYEAAVPFDKYRVILPPTIGHAD-SSYINASHIKGYFF--DYIAAQDPVSEgTAFDFWRMIADQNVTTVVM
..|| .|  .  . | . |     |  ||||     .|  || |   .   . . || | .|.  |.   || .| |  | |  |||||| ..| |..||
kqefsnlpgdppsdlctvfnqp.vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkke.tradfwrmiwqenttaivm

LSD--ETDWSDVEKYWPIDgsgTECHFGSERNSVNVTCVSEEHHQDFIIRNLSYsmKDNesmpaNQEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRq
| .  ||.   . .|.| .   . | .  .. ||.    . ..       ||||  . .      . . .. .  || |  ||.|.. .....  .  | 
lcqfletnrekcaeyfprn...ahcclqfdklsvsyedstvnkslvttrlnlsy..ege.....trlithwlwkewp.dwqvpessevmlkilrkirar.

sslmgsQAPIVVHCRNGSSESGIFICISLLWLRQKAEQ-RIDVFQTVKGLQS-HRPMMFTRFEQYSFCYRALAD
       .| |.||  |   || .... .     ..     |. | |  |.   |      ..|| . .. | |
......stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1000-1107 8.6e-15 49.3 In-house 164-276 (287) alignment 
Range on Protein: 1000-1107
Range on HMM: 164-276/287.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRL---RELPQFN--NSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSL
....| . |... .| |  ..  . ||.||.       || .      |.|.|...|.||.|.....  .... .   . ..   |  || .|. .||. 
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

EQYVFIYKALAEW
 |. ..|.||. .
vqlrllyealvty
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1009-1108 1e-14 48.7 In-house 186-285 (302) alignment 
Range on Protein: 1009-1108
Range on HMM: 186-285/302.0
YHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWH
|..|||.. | |.  . | . .  . .. .  ....||    |.|| |.|..    ...  .... || | | ..| ||  .|.||.|||..| ||. . 
yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1165-1442 2.1e-14 47.6 In-house 23-288 (302) alignment 
Range on Protein: 1165-1442
Range on HMM: 23-288/302.0
NGETGLEEEFKKLErNLTTPLSSnFAAKDENLLKNRYEAAVPFDKYRVILPptigHADSSYINASHIKGYF--FDYIAAQDPVSEGT--AFDFWRMIADQ
  .. ...||||.. .. ..| .   |  .|| ||. |     |. .|.|.    ..  ||.|||...        | || |... .    .||||....
ldtaevkkefkkid.tmkvdlek.Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqe

NVTTVVMLSDETDWSD-VEKYWPIDgSGTECHFGSERnsVNVTCVSEEHHQD--FIIRNLSYSMkdNESMPANqevVqYSYTGWPSDSIVpKSANSLMNL
....||.|  | . .  .....|   ||.  ..|. .  ||.  |.. . .   ..|  |   .   .|. ||   | |  | |.....  .. ..|.. 
kivsvvilvgeeelkktlselfpkk.sgdykeygkmf..vNnrkVekaeeektryviEvlPegc..snsvlan...v.yvltnWkqkkvp.vkyaelikt

IEMVlqrQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKT
.. |     . . .....|.   ||.   |.|.   .   . ....   . ..|| . | || .   ..|| . |.||. || | 
aakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_CG42327_pd Subfamily CG42327 1040-1107 3.3e-14 47.3 In-house 246-314 (319) alignment 
Range on Protein: 1040-1107
Range on HMM: 246-314/319.0
NNSPVVIHCSAGVGRTGTFISIDSMLdQCLAED--KANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
.. |.|.||| ||||||. |. |  . . | |     .| . |  .||.|   |.. ||| |||| | |.
sqGPlvvhcsdGvGrtGlviasdiai.rsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_eak_pd Subfamily eak 1185-1441 3.8e-14 46.8 In-house 42-307 (332) alignment 
Range on Protein: 1185-1441
Range on HMM: 42-307/332.0
LSSNFAAKDENLLKNrYEAAVPFDKYRVILPPTIGHADsSYINASHIK--GYFFDYIAAQDPvSEGTAFDFWRMIADQNVTTVVMLSDET--DWSDVEKY
|| . .|. |.. .|    .||.|.| | | ..    .  ||||| ..       || .  . ||   | ||.|. .|.  ..|.| ..   .    .||
lsisetarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGia.sedkvfafwqmvleqkspaivqlledvelkleksdky

WPIDGsGTECHFGSernsVNVTCVSEEHHQDFIIRNLSYSmKDNESmpanQEVVQYSYTGWPS-----------------DSIVPKSANSLMNLIEMVLQ
.| ..   | .||     ..|.. .  ... .  |.|  | | ||.     .|  | . ||                   .  |.. ..   .|.. .|.
fpdkt.reelkfGi....ldverkefvkrniletrllels.kGnet....hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlk

RQSSLMGSQAPIVvHCRNGSSESGIFICISLLW--LRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISK
.      | |||.  . .||. .|.|. | ||   . .| .    | . .   .|.|        |.|| | .. ||. .
kyihtppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1000-1107 5.1e-14 46.6 In-house 163-268 (281) alignment 
Range on Protein: 1000-1107
Range on HMM: 163-268/281.0
ANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRElpqfNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAE-DKANIFEFVCNLRR-QRNLMVQSLEQY
  ..| | .. . .| |.. || |  .|. . ..|       .| ||||||||||.||.....  |.   .     .| . |  ||   |   ||.|.||
egetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqy

VFIYKALAEW
..|.| | ..
mliwkvlldf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1182-1349 9e-14 45.7 In-house 81-238 (244) alignment 
Range on Protein: 1182-1349
Range on HMM: 81-238/244.0
TTPLSS--NFAAKDENLLKNRYEAAVPFDKYRVILppTIGHADSSYINASHIK--GYFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETdwsDV
  |  |  . | . .|  |||  |..|||  || |  . |    .||||| .   |   .|| .| |... |..|||.|. .. |  .|.|       . 
irpdpsvmkdafnpnnswknregaglpfdfnrvpl..skgsmgntyinasfvgclgrtaeyiltqhplad.tsmdfwkmmlerhvnvlvvlgsve...ee

EKYWPiDGSGTECHfgseRNSVNVTCVSEEHHQDFIIRNLSYSMKDNESmpaNQEVVQYSYTGWPSDSIVPK
..||| |    | .     . . ||    .  ..    ||      |||    | .  .  . ||||   |.
deywp.dseplewy....eeditvtltdrdefknikasnleiesdmnes...hqaltmfqisnwpsdgttpn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1331-1436 1.2e-13 45.2 In-house 89-191 (440) alignment 
Range on Protein: 1331-1436
Range on HMM: 89-191/440.0
QEVVQYSYTGWPsDSIVPKSANSLMNLIEMVLQRQSSlmGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSF
. . || | ||| |  ||| |  ....|. | . |     ...|..|||  |.. .|. |..  .    |  ..||.|  .. ... || |    |||.|
rtlkqyhyqgwp.dkgvpkfagpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYRALA
 . |. 
vheavl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1045-1106 1.7e-13 44.7 In-house 2-63 (69) alignment 
Range on Protein: 1045-1106
Range on HMM: 2-63/69.0
VIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAE
|.|||.| |||||||.|   . .  .|   .||. |  .|. | .||    .|.||. ||.|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1164-1441 1.8e-13 44.9 In-house 18-289 (305) alignment 
Range on Protein: 1164-1441
Range on HMM: 18-289/305.0
SNGETGLEEEFKKLERNLTTPLSSNFAAKDEnLLKNRYEAAVPFDKYRVILPPTIGHadsSYINASHIKG--YFFDYIAAQDPVSEgTAFDFWRMIADQN
 .| .|| .||. ..|         |   .|   ||||     .|. || | ..  |    || | ..        .| .| |. . |  ||| |  ...
ekgpaglraefvamkrfndfekmkafkeaqe.agknrykdvgcldnnrvklegpwph...eyihanyvstptnpkrfictqaplek.tcadfwymclqdk

VTTVVMLSD--ETDWSDVEKYWPIDGsGTECHFGSERNSVNVTCVSEEHHQdFI---IRNL-SYSMKDNESMPANQEVVQYSYTGWPsDSIVPKSANSLM
| .. || .  |       .|.. .  . . .|  . . . | . | .  . |      ..    .  . .   .. | .| .  || |  || . ....
veaifmlcnllekgakkcleyfaskd.kdvlefeekgqkisvkfessvtlk.frkdakakvtetvlviegpgekarkvthyhwidwp.drgvpaadlail

NLIEMVlqRQsslmgSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQ-TVKGLQSHRPMMFTRFEQYSFCYRALADYISK
.|.|    |      |. ||||||  |   .|  . .  .  .  | | |.  .  .. ..  |       .|| | .. . .|. |
elleka..rp.....skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1045-1107 3.6e-13 43.6 In-house 1-63 (69) alignment 
Range on Protein: 1045-1107
Range on HMM: 1-63/69.0
VIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
|.|||.| |||||||.|   . .  .|   .||. |  .|. | .||   ..|.||. ||.| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1251-1412 4.2e-13 44.0 In-house 42-194 (255) alignment 
Range on Protein: 1251-1412
Range on HMM: 42-194/255.0
FDFWRMIADQNVTTVVMLSDET--DWSDVEKYWPIDGSGTEChFgserNSVNVTCVSeeHHQDFIIRNLSYSMKDNEsMPANQEVVQYSYTGWPSDsIVP
  |...|  .. ..||||.| .  .  . ..|.|..  .    .    . ||||.      .| ..| |    .  |     ..|  |||.||.     |
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.l....advnvtttk..ssadvvlrtleitstlge.kkkthtvkhysykGWiek.naP

KSANSLMNLIEMVlqRQsslmgSqAPIVVHCRNGSSESGIFICISLLWL------RQKAEQRIDVFQTVK
. |. ..|.. .|  |.     |  ..|||| .|   |  |. . |..       ..     .|  . ..
elareilnilkvv..rd.....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1038-1107 3.4e-12 40.4 In-house 262-343 (349) alignment 
Range on Protein: 1038-1107
Range on HMM: 262-343/349.0
QFNNSPVVIHCSAGVGRTGTFISIDSMLD------------QCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW
. . |....||||| ||||... .|..|.            .  |  |  |.  | .||.||  ||| | |...||.|| ..
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1041-1103 5.2e-12 40.2 In-house 228-290 (297) alignment 
Range on Protein: 1041-1103
Range on HMM: 228-290/297.0
NSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKA
| ....||||||||.|  .  | .|..   .   ..  ..  || ||  .||.|||. ..|.|
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 890-971 1.3e-11 39.1 In-house 2-85 (199) alignment 
Range on Protein: 890-971
Range on HMM: 2-85/199.0
KEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANlTEKNRQ-QCAKYWPDE--QITRYGDIIVEPASFSFHSDYAIRAFDIA
| .. .||.| |.  |. |||.||||  |  |||| .  .||.. . . |||      ..|| . |   . . ..||.| |. ..
kgqrryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 892-971 1.6e-11 38.7 In-house 3-84 (198) alignment 
Range on Protein: 892-971
Range on HMM: 3-84/198.0
KKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANlTEKNRQ-QCAKYWPDE--QITRYGDIIVEPASFSFHSDYAIRAFDIA
.. .||.| |.  |. |||.||||  |  |||| .  .||.. . . |||      ..|| . |   . . ..||.| |. ..
qrryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1002-1102 4.5e-11 37.3 In-house 93-198 (199) alignment 
Range on Protein: 1002-1102
Range on HMM: 93-198/199.0
NSRRILQYHFTNWNDYKAPECSTgLLRFMYRLRELP----QFNNSPVVIHCSAGVGRTGTFISIDSMLDqCLAEDKA---NIFEFVCNLRRQRNLMVQSL
 .| | .| || |..  .|. .  .. |.   ||.     | ...||..||| | | || |...|  .     | |.   ..||    ||. |  .. ||
streishyqftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvr.sheesktsvvdlfevakrlrqarcgiissl

EQYVFIYK
..| |||.
qhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1002-1102 4.5e-11 37.3 In-house 92-197 (198) alignment 
Range on Protein: 1002-1102
Range on HMM: 92-197/198.0
NSRRILQYHFTNWNDYKAPECSTgLLRFMYRLRELP----QFNNSPVVIHCSAGVGRTGTFISIDSMLDqCLAEDKA---NIFEFVCNLRRQRNLMVQSL
 .| | .| || |..  .|. .  .. |.   ||.     | ...||..||| | | || |...|  .     | |.   ..||    ||. |  .. ||
streishyqftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvr.sheesktsvvdlfevakrlrqarcgiissl

EQYVFIYK
..| |||.
qhynfiyq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1194-1439 5e-11 36.8 In-house 46-279 (303) alignment 
Range on Protein: 1194-1439
Range on HMM: 46-279/303.0
ENLLKNRYEAAVPFDKYRVILpptighADSSYINASHIKGYF-FDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETDWSDVEKYWPIDGSGTECHF
.|. |||.   . .|. .| |      .||||| ||...       | .| |.|  || |||.|| .|.|  |..|  .... ..     .       .|
knmdknrfvdvicldhskvkl......sdssyihasyleldsskkailtqlplsh.taadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

gsERNSVNVTCVS-EEHHQDFIIRNLSYSMKDNESMpanqeVVQYSYTGWPSDSIVPKSAnslMNLIEMVLQRQSSLM--GSQAPIVVHCRNGSSESGIF
  |  |. |      |  . . .. || |  |  |.     .  . |  || .||  ...    ...  . | || |       | |     |   .| |
..eersirvgefkrvelgdgwvlkvlsvsngdyksf.....lhvhhykawphnsipsdgs...pkfvkqiwqlqsvlrkysdstptvymslsgcgragtf

ICISLLWLRQKAEQR-IDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI
  .    |  ..||  .|. . .. ..  |      . |.|. |  ||...
alfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 846-942 5.4e-11 36.4 In-house 44-156 (349) alignment 
Range on Protein: 846-942
Range on HMM: 44-156/349.0
NRKENAIKNRYNDIRAFDDTRVKLKKI--------------NGDDYSDYINANFIKS--WKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTE
.  |   ||||.||  .. .||||||               ..    ||||||..|    . .| .|| |||. .|. ||....  ..  |.. . .  |
eGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

KNRQQCAKYWPDE
.. ..| .|| . 
lslekcdiywqel
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 850-935 3.6e-10 33.8 In-house 34-118 (332) alignment 
Range on Protein: 850-935
Range on HMM: 34-118/332.0
NAIKNRYNDIRAFDDTRVKLKKINGDDysDYINANFIKSWKEKKLFIAAQAPV-DATIGDFWRMVWEQESYLIVMVANLTEKNRQQC
|   ||   . .|| .||.|   .| |  |. ||...  . .|  .| ||||. | |   ||||| |..  .|... .. ||.....
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1375-1437 6.2e-10 33.3 In-house 1-63 (69) alignment 
Range on Protein: 1375-1437
Range on HMM: 1-63/69.0
IVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALAD
.||||  |.  .| ||.| .   | |.|. .|.|  |. ..  ||||     .| | . ||..
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1376-1437 8.1e-10 32.9 In-house 1-62 (69) alignment 
Range on Protein: 1376-1437
Range on HMM: 1-62/69.0
VVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALAD
||||  |.  .| || | .   | |.|. .|.|  |. ..  ||||    ..| | . ||..
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_hpo-7_pd Subfamily hpo-7 1252-1411 8.6e-10 32.9 In-house 49-199 (263) alignment 
Range on Protein: 1252-1411
Range on HMM: 49-199/263.0
DFWRMIADQNVTTVVMLSD--ETDWSDVEKYWPIDGSGTEChFgserNSVNVTCVSEEHhqDFIIRNLSYSMKDNEsMPANQEVVQYSYTGWPSDSiVPK
 |...|  .. ..||||.|  | .  . ..|.|..  .    .    . |||..    .  | ... |      .|     ..| .|||.||.     |.
kfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk.l....anvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWiekn.dpe

SANSLMNLIEMVlqRQsslmgSqAPIVVHCRNGSSESGIFICISLLWlrQKAEQRID--------VFQTV
 |.. .|.....  |.     |  ..|||| .|   |  |  . |..  ||  . .|          . .
lareilnilkva..rn.....s.kslvvhcstGiGrsaafsvaElvy..qkmirsldttstveldylsLl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 844-922 1e-09 32.4 In-house 30-114 (347) alignment 
Range on Protein: 844-922
Range on HMM: 30-114/347.0
ASNRK-ENAIKNRYNDIRAFDDTRVKL-----KKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIV
.|.    .  ||| .| .  |.||| |     |. . ||   ||||  ||  . .| .| .| |.  |. |||.||       .|
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 850-967 1.3e-09 32.6 In-house 19-147 (290) alignment 
Range on Protein: 850-967
Range on HMM: 19-147/290.0
NAIKNRYnDIRAFDDTRVKLKKINGDDYSDYINANFIKSwKEKKLFIAAQAPVDA-------TIGDFWRMVWEQESYLIVMVANLTEKNRQ----QCAKY
.....|. ..  . .||| ||       .||| ||...   .   .|. |.|  .       || .|| |. . ..  .||. . .||...    .||||
hemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvtc.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPDEQ--ITRYGDIIVEPASFSFHSDYAIRA
 |..   . ..... |.  |  .. |  .| 
vpesvgeelkfkgltvkCkskekeddvetRe
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 835-940 4.1e-09 30.5 In-house 31-130 (303) alignment 
Range on Protein: 835-940
Range on HMM: 31-130/303.0
LPHFQLDTVASNR-KENAIKNRYNDIRAFDDTRVKLKKingddySDYINANFIKSWKEKKlFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQ
.  .   .|. |.  .|  |||. |.  .| ..|||        | || |....   .||  | .| |.  |  |||.|. ||    ....   .| .. 
vvsylppsvsknqfvknmdknrfvdvicldhskvklsd......ssyihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydkl

QCAKYWP
     .|
ggdsvfp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 889-941 4.8e-09 30.0 In-house 232-281 (440) alignment 
Range on Protein: 889-941
Range on HMM: 232-281/440.0
WKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKnrqQCAKYWPD
.  |. |||.| |.|.|. ||||.| . .   |.|. .| .|    |. ||| 
yskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 819-899 1.3e-08 28.9 In-house 16-94 (95) alignment 
Range on Protein: 819-899
Range on HMM: 16-94/95.0
VRHRDTDFLFAQEYESLPHFQLDTVAS-NRKENAIKNRYNDIRAFDDTRVKLKKingDDYSDYINANFIKSWKEKKLFIAAQ
  | ..|  | .|. |..     . .    . |  |||. .|  .| ||| |        |||||| |.  .  |. .||||
emhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1183-1273 1.7e-08 28.4 In-house 25-121 (347) alignment 
Range on Protein: 1183-1273
Range on HMM: 25-121/347.0
TPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPT---IGHADS--SYINASHIKG--YFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETD
.|    ..  . .| |||       |. ||.| |     ..||   .||||||||      .|| .| |. . |  |||.|.   .|| || . .   
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpd.tvrdfwkmvsvtkvtqvvtifepik
subfamily_CG42327_pd Subfamily CG42327 1365-1440 4.1e-08 27.3 In-house 240-316 (319) alignment 
Range on Protein: 1365-1440
Range on HMM: 240-316/319.0
QSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAE-QRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
.|.   || |.|||| .|   .|. |   .   . .   . .|. |.|  ..  |       ||| | |. |  |  
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 830-952 4.9e-08 26.7 In-house 30-153 (302) alignment 
Range on Protein: 830-952
Range on HMM: 30-153/302.0
QEYESLPHF--QLDTvASNRKENAIKNRYNDIRAFDDTRVKLKKINgddySDYINANFIKSWKEKKLFIAAQAPVDATI---GDFWRMVWEQESYLIVMV
.|.... ..  .|.   .  |.|  ||. .|... |...|||.. .     .|.||  ..  . ..  | || |.  .     .|||||....   .|..
kefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

ANLTEKNRqQCAKYWP--DEQITRYGDIIV
.   | ..    ...|   .. . ||.. |
vgeeelkk.tlselfpkksgdykeygkmfv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1197-1440 5.1e-08 26.6 In-house 50-345 (349) alignment 
Range on Protein: 1197-1440
Range on HMM: 50-345/349.0
LKNRYEAAVPFDKYRVILPPTI------GHA--------DSSYINASHIKGYFF----DYIAAQDPVSeGTAFDFWRMIADQNVTTVVMLSDETDwSDVE
 ||||.  .|..  ||.|. ..       ..           |||| ..|   .     ||| | |.   |  ||...|  ..|  |. |.|. .  ..|
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlP.stvddfykvillngvklvlsLnddke.lsle

K---YWPiDGSGTECHF---GSERNSVNVT-------CVSEEHH-QDFIIRNLSYSMKD-NES--MPANQ--EVVQYSYTGWPSDSIV--PKSA----NS
|   ||  ..| .. .     |  ...||         | ..    | . .|     .| ...  .  ..  |..|  .  |.  |..  |.|     . 
kcdiywq.elsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalev

LMNLIEMVLQRQSSLMGSQAPIVVHCRNGSSESGIFICI----SLLWLRQKAEQRIDV--------FQTVKGLQSHRPMMFTRFEQYSFCYRALADYIS
  .||.    |.       ....|||  |   .|... .    |.|   |.   .|..        . .|  |.  |  |   . |. ..| ||  |..
kndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1006-1103 6.3e-08 25.6 In-house 206-304 (346) alignment 
Range on Protein: 1006-1103
Range on HMM: 206-304/346.0
ILQ-YHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKA
| | .| . |.  . |  .  ........    |..|  | .    | ||. .||     ..|     . ||.| . |...||   |.|. ||  ||  
icqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 847-942 8.2e-08 25.2 In-house 23-86 (169) alignment 
Range on Protein: 847-942
Range on HMM: 23-86/169.0
RKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINAnfikswkekklfiaaqapvdatigdfwRMVWEQESYLIVMVANLTEKNrqqcaKYWPDE
   |  |||     |   |||||...  |  ||||||                           ||.|| .. .||.. .  .||      .||. 
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpek
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 847-941 9.9e-08 25.1 In-house 24-86 (169) alignment 
Range on Protein: 847-941
Range on HMM: 24-86/169.0
RKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINAnfikswkekklfiaaqapvdatigdfwRMVWEQESYLIVMVANLTEKNrqqcaKYWPD
   |  |||     |   |||||...  |  ||||||                           ||.|| .. .||.. .  .||      .||.
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 827-890 1.4e-07 25.2 In-house 23-87 (440) alignment 
Range on Protein: 827-890
Range on HMM: 23-87/440.0
LFAQEYESLPHFQLD--TVASnRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWK
 | .|.  ||    .   .||   .| .|||| .| |.| .|| |....|   |||||| .|.. .
afedewsllpsglsqpsdias.lpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1194-1287 1.5e-07 25.2 In-house 33-126 (332) alignment 
Range on Protein: 1194-1287
Range on HMM: 33-126/332.0
ENLLKNRYEAAVPFDKYRVILPPTIGHADssYINASHIKGYFF--DYIAAQDPVSEGTAFDFWRMIADQNVTTVVMLSDETDWSDVEKYWPIDGSG
.|.  ||      ||. || | |  |. |  . ||| . ||     || || |. . | . ||||..... . .... |  .    .  . |   |
nnmdmnriphlycfdhsrvelapqdgkdd..fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1155-1242 2.1e-07 25.0 In-house 10-94 (95) alignment 
Range on Protein: 1155-1242
Range on HMM: 10-94/95.0
VSSRESMTTSNGETGLEEEFKKLErnLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILpptIGHADSSYINASHIKGYFF--DYIAAQ
. |      || .  ...||| .   .|.  .    . . |. |||.   .|.|  ||.|     . || ||||  . ||     |||||
fhshvlemhsnsdqefdnefksis..mtsgapytvgsseanipknrflnifpydatrvvl...ttkrdsdyinacfvdgyarkncyiaaq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1204-1349 2.8e-07 24.9 In-house 2-129 (130) alignment 
Range on Protein: 1204-1349
Range on HMM: 2-129/130.0
AVPFDKYRVIlpptighaDSSYINASHI--KGYFFDYIAAQDPVSEgTAFDFWRMIADQNVTTVVMLSDETdwsDVEKYWPiDGSGTECHfgseRNSVNV
|..|.  |.         .  ||||| .   |   .|. .| |... |. |||.|. .. |  .|.|       . ..||| |    | .     . . |
alefevsrlq........gntyinasfvGllgrtaeylltqhplad.tsmdfwkmmleryvnvlvvlgsve...eedeywp.dsePlewy....eediiv

TCVSEEHHQDFIIRNLSYSMKDNESmpaNQEVVQYSYTGWPSDSIVPK
|    .  .     ||  . . |||    | .  .  . ||||   |.
tltdrdefknikasnleiesdlnes...hqaltmfqisnwpsdgttpn
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1009-1102 3.2e-07 24.8 In-house 163-253 (290) alignment 
Range on Protein: 1009-1102
Range on HMM: 163-253/290.0
YHFTNWNDYKAPECSTGLLRFMYRLRelpqFNNSPVVIHCSAGVGRTGTFISIDSMLDQCL-AEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYK
. . .||. ...| .  ||  .  ..     ...||..||  |. |  .. .|.         ... .. . . .||.||.|...| ... |.  
sllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
PTEN_1 1007-1098 3.7e-07 25.1 In-house 95-185 (196) alignment 
Range on Protein: 1007-1098
Range on HMM: 95-185/196.0
LQYHFTNWNDYKAPECSTgLLRFMYRLRELPQFNNS--PVVIHCSAGVGRTGTFISIDSMLDQClaEDKANIFEFVCNLRRQRNLMVQSLEQYV
..|.   ..|. ||  |  |... ... |  . ...   |..|| ||.||.|| .    |  .    .  . .|.|.  | ....   |.|...
veylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk..ltadeAlelvrekRppgapnspsqerll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1168-1233 1.1e-06 22.3 In-house 22-85 (440) alignment 
Range on Protein: 1168-1233
Range on HMM: 22-85/440.0
TGLEEEFKKLERNLTTPlsSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKG
   |.|.  |   |..|  |. |.  .| .||||   . .|. ||.|    |  || |||||.|.|
rafedewsllpsglsqp..sdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_DSP23_pd Subfamily DSP23 997-1101 1.7e-06 22.8 In-house 42-139 (148) alignment 
Range on Protein: 997-1101
Range on HMM: 42-139/148.0
GQFANNSRRILQYHFTNWNDYKAPEcSTGLLRFMYRLRELpQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKAnifefVCNLRRQRNLMVQSLEQ
|.   ..   | ..  . .||. |     . .|.  . |  . .|  | .||  | |||||...   .  . ||  .|     . ..||.|   |...||
grphveatpnltlvrlriddyhppa.leqvvefvrvveea.eekneavsvhcllgrgrtgtmlacylvkerklaaaea.....iaevrrlrpgsvetveq

YVFIY
   ..
eklvr
subfamily_PTPDC1_pd Subfamily PTPDC1 1007-1099 1.7e-06 22.6 In-house 83-167 (182) alignment 
Range on Protein: 1007-1099
Range on HMM: 83-167/182.0
LQYHFTNWNDYKAPECSTgLLRfMYRLRELpQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKAnifefVCNLRRQRNLMVQSLEQYVF
. ..   |.||...   . .|  . .. .    ..  | .|| || ||||  |.   .  . |. .||     .  .| .|   .|. ||  .
iyvynfgwkDygvasler.iLd.ivkvvaf.alqegkvavhChaGlGrtGvliacylvyakrltaeka.....iklvrskrpksiqtreqvel
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 877-945 1.9e-06 22.2 In-house 12-75 (130) alignment 
Range on Protein: 877-945
Range on HMM: 12-75/130.0
YSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNrqqcaKYWPDEQIT
  .||||.|.      . .. .|.|. .|  |||.|. |.   ..|..  . |..     .|||| .  
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1003-1068 1.9e-06 22.2 In-house 115-175 (255) alignment 
Range on Protein: 1003-1068
Range on HMM: 115-175/255.0
SRRILQYHFTNWNDYKAPECSTGLLRfMYRLRElpqfNNSPVVIHCSAGVGRTGTFISIDSMLDQC
 . .  |... | . .||| .  .|  ....      .  .||.|||.|.||. .|. ....  . 
thtvkhysykGWieknaPelareiln.ilkvvr....dsksvvvhCstGiGrsaafvlaelvyqkm
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 847-888 2.9e-06 21.1 In-house 36-76 (244) alignment 
Range on Protein: 847-888
Range on HMM: 36-76/244.0
RKENAIKNRYNDIRAFDDTRVKLKKINgDDYSDYINANFIKS
   || |||| .|  ||.||| |   .  . |||||||.|..
lsanatknryinilpfdetrvilsssk.kegsdyinanyiqg
V-set Immunoglobulin V-set domain 174-263 5.2e-06 17.3 Pfam-A 8-102 (114) alignment 
Range on Protein: 174-263
Range on HMM: 8-102/114.0
HPSTSVSKGIDVTLFCCINvdpEgFIDVASVFFIQNGT------IMREAT---SHPFAPRNGLARRVHEKYS--CWELEIKNAQTSDSGSYMCRVTASas
... .|. |..||| |      .   .. |. ... .|      |.|  .    . . ..    ...    |   . | |.| . .||| | |.|. |  
prpvtvaeGgsvtLpCfys...s.sensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds..

D
.
n
fn3 Fibronectin type III domain 410-520 5.9e-06 19.5 Pfam-A 5-82 (85) alignment 
Range on Protein: 410-520
Range on HMM: 5-82/85.0
DVRVLNSgSALSCEVEWKSPAEPNGRITKYFVSVRGAMRKSdgsltpddlpaavevdkrcanwdgdentskhnG----InpiDFANEFySCKFGPLKPNR
...| .  .. | ...|. |....| ||.| | .| .   .                                           ...  |...  |||..
nlsvsev.tstsltlsWsppkdgggpitgYeveyrekggge................................ewkeft...vprttt.svtltgLkpgt

NYTVTVWAENSAGRS
.|...| | | || .
eYefrVqavngageg
subfamily_PTEN_pd Subfamily PTEN 1038-1104 6.7e-06 21.2 In-house 111-178 (184) alignment 
Range on Protein: 1038-1104
Range on HMM: 111-178/184.0
QFNNSPVVIHCSAGVGRTGTFISIdSMLDQCLAEDKANIFEFVCNLRRQRNLMVQ--SLEQYVFIYKAL
. ..  ||.|| || ||||. |.   .| ..| |.. .. |.  . | . .  |.  |   ||  |..|
edkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1238-1285 7.7e-06 19.5 In-house 238-283 (440) alignment 
Range on Protein: 1238-1285
Range on HMM: 238-283/440.0
YIAAQDPVsEGTAFDFWRMIADQNVTTVVMLSDETDWSdVEKYWPIDG
.||.| |. . | .||||.. | ...|..|| .  | . .  |||.. 
fiatqmpl.dstvldfwrlvhdyristiimlnqlndkt.csiywpvnt
0038934 (Phosphotyrosine protein) phosphatases II 1013-1060 8e-06 21.1 In-house 87-134 (194) alignment 
Range on Protein: 1013-1060
Range on HMM: 87-134/194.0
NWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFIS
  .|. .|  .. |  .    . | . ..  |..|| ||.|||||.. 
fpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva