Gene dep-1 in Caenorhabditis elegans

Synonym: CELE_F44G4.8, dep-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP049_AA protein Get Run
CeleP049_AA_1054-1336 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 1047-1338 4.3e-129 424.7 In-house 2-288 (293) alignment 
Range on Protein: 1047-1338
Range on HMM: 2-288/293.0
NKSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQG
.||.|...|.|..||. |.||||.||||||.....||  |.|.|.||..|| |||.||| .||||||||.. .. .| |||||||.||..|.|||||.||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKsgpdGRVTRFVRHWHYMAWPDFGAPS
|||.|.|.||.|.||... .|. ||..||||. ||..|||..|. |||||||.||.|||.| ...|||....||    .. .| ||..|...|||.| |.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPe

HPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGS
... ...| |..|... .. ...|..|||||||||.||||..|||||. .  | .|.||.|.|.| ||...||.|.|||||| |.|..|. .
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPRD_pd Subfamily PTPRD 1049-1336 7.6e-107 353.3 In-house 2-282 (564) alignment 
Range on Protein: 1049-1336
Range on HMM: 2-282/564.0
SRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVgVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPL
|.|. ......||. . |.||..|.|||  ...     .. |.. |.|..|||. ||  ||||||.||. .. || |||||... |. .|...||.||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRvtRFVRHWHYMAWPDFGAPSHP
..| . ||.| |||..  |. |||..|||..|||.|||.. . .  ||...||...|.|. ...||...|.|.  .    | ||..|...||| |.| ..
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkksses..reVrqFhFtsWPdhgvpesa

NGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
...... |  |.. .  |.. |..|||||||||.|||| || .|.     . .|....| ..| .|  |||.|.||||||. ||. |.
tslLdlirkvralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0051299 (Phosphotyrosine protein) phosphatases II 1049-1334 3.1e-96 317.5 In-house 2-285 (288) alignment 
Range on Protein: 1049-1334
Range on HMM: 2-285/288.0
SRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPL
......|.....|. . |..  .. ||....... .  .. |. || |..|||...|. |||||||||.....||.|||||.|..|. . |.|||.||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSG--PDGRVTRFVRHWHYMAWPDFGAPS
|.| ..||.| |||... |. |||.||.|| ||.||||.  . .. |||| ||.. |...|....| ..... .    .  .|.|.|.||..|||.|.|.
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

HPNGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
.|. ...| |..|..|.  ... |..|||||||||.|||| .| ||.   ..  .||...|. .|  |..|||...||.|.....|  
spellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0050432 (Phosphotyrosine protein) phosphatases II 1038-1335 4.3e-93 307.3 In-house 12-299 (308) alignment 
Range on Protein: 1038-1335
Range on HMM: 12-299/308.0
YTVVTGANTNKSRPVRIEDFADHVrlMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLsnpnNiEGGDYINANYVPGF--
....    ...| .....|.. ..  ..|..  ...||.  ...| .  .  ...|| |..|||...|. ||||||||    . || |||||.||.|.  
llfrdtsilvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyss

SSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHEN-VPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHW
 ..|.|||.|||||.| ..||.| |||... |. |||.||.|| ||.||||. ..  .. ||.. ||.. |...|....| ..|...| .   .|.|.|.
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthf

HYMAWPDFGAPSHPNGIIQFSRMFRHHLphspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
||..|||.|.|..|. ...| .. |..|     . |..|||||||||.|||| .| ||.    .  .|||..|. .|  |..|||...||.|.....|  
hytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

L
|
l
0040438 (Phosphotyrosine protein) phosphatases II 1055-1336 6.1e-92 303.5 In-house 3-277 (317) alignment 
Range on Protein: 1055-1336
Range on HMM: 3-277/317.0
EDFADHVRLMSADSDFRFSEEYDMMRNVGVGqSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDH
.|. ... .. . .  ...||. ..... .  .   .||| |..|||...|. |||||||||....... |||||.||.|.. .|.|||.||||| | ..
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQF
||.| |||..  |. ||...|.|| ||.||||.  . .. |||. ||.. |.| .....| ...|..  ..  .|.|.|.||..|||.|.|..|. ...|
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldf

SRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 .. |..|.  ... |..|||||||||.|||| ....|.    .  .||. .|.|.|  |...||...||.|.....|. |.
leavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1052-1338 2.4e-91 301.1 In-house 2-283 (318) alignment 
Range on Protein: 1052-1338
Range on HMM: 2-283/318.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
. .||...||| . .. .  .||||...  .    .   |  |.|. |||..|| .|||.||||.. .. || |||||||..|. .....||||.||| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHEnvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGI
 . ||.| |||..  |. ||...|.|..|.|.|||...  .  ||.. |..  |.|....|.| ....... .   .| || .|| .||| | |... ..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteee..esrqvrqyhytsWpdegvpesgasl

IQFSRMFRHhLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGS
... |  ..   ... . |..||||||||| |.|| .| ||.       .|||.|| ..| .|  ||| |.||.||.  .|. |.  
ldlvrqvsk.aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
0046845 (Phosphotyrosine protein) phosphatases II 1072-1335 8.1e-90 296.3 In-house 2-274 (284) alignment 
Range on Protein: 1072-1335
Range on HMM: 2-274/284.0
FSEEYDMMRNVGVGQ--SVAASELPINRPKNRFTNIPSYDHSRVKLSNPNN-IEGGDYINANYVPGF-----SSRREFIAAQGPLPTTRDHFWQMTWEQQ
. ||. ..... | .  |. .. || |. |||...|. ||||||||..... .|..|||||.||.|.      ....|||.|||||.| ..||.| |||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CPAIIALTKCVEKGRDKCHQYWPDHeNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLP
.. |. ||..||.|| ||.||||.  . .. |||. ||.. |...| ...| ..|.. |..|  .|.|.|.||..|||.|.|..|. ...| |. |..|.
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytg.esrtvthfhytswpdhgvppspedlleflrlvrelle

HSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGD---PIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
..| . |..|||||||||.|||| .| ||.    ..    .||...|. .|  |..|||...||.|.....|  |
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1063-1335 2e-89 295.1 In-house 6-277 (297) alignment 
Range on Protein: 1063-1335
Range on HMM: 6-277/297.0
LMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLsnPNniEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQ
|.....  ....|.. . .. .  |  ...|| |..|||...|. |||.||||  ..  || |||||.||.|..  |.|||.|||||.| ..||.| |||
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..dd..egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

QCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKE--FDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRH
... |. ||..||.|| ||.||||. |. .. |||. || . ...  .|....| ..... | .   .|.|.|.||. |||.|.|..|. ...| ...|.
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng..esrtvthfhytgwpdhgvpespaslldfielvrk

HLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSS---FGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
.|...| . |..|||||||||||||| .| .||          .|.. .|...|  |...||...||.|.....|. |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 1063-1334 4.4e-89 293.8 In-house 5-271 (273) alignment 
Range on Protein: 1063-1334
Range on HMM: 5-271/273.0
LMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLsnpnNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQ
|.....  .. ||....... .  .  ...|| |. |||...|. ||||||||    . .| |||||.||.|. . |.|||.||||| | ..||.| |||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

QCPAIIALTKCVEKGRDKCHQYWPDHENV-PVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHH
... |. ||..||.|| ||.||||. ..  .. ||.. ||.. |...| ...| ..|...| .   .|.|.|.||. |||.|.|.... ...| .. |..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrka

LPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
| ..|.| |..|||||||||.|||| .| ||.    .  .||. .|. .|  |. |||...||.|.....|  
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 1048-1336 4.7e-88 290.8 In-house 10-290 (297) alignment 
Range on Protein: 1048-1336
Range on HMM: 10-290/297.0
KSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGqsVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNI-EGGDYINANYVPGFSS-RREFIAAQ
.| |.... .. ...|. |.|  .. .|. .. .. .      ..|| |..|||...|. ||||||||. ...  .. |||||.||.|..   |.|||.|
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRdKCHQYWPDHENvpvLYGDIEVTIVAEKEFDEFVIRDIRLEKsgpdGRVTRFVRHWHYMAWPDFGAP
|||| | ..||.| |||....|. |||.||.|| ||.||||. ..    |||. || . ... | ...| .....    .  .|.|.|..|. |||.|.|
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvp

SHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.... ...| .. |..| ..| . |..|||||||||.|||| ....|.    .  .||. .|.|.|  |...||...||.|.....|. |.
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 1045-1335 7e-88 290.6 In-house 2-304 (307) alignment 
Range on Protein: 1045-1335
Range on HMM: 2-304/307.0
NTNKSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGV--GQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNI-EGGDYINANYV--------P
... |........  .|.|. .|.  .. .|. ....| |    .  ...|| |..|||...|. |||.|||||....  |..|||||.||        .
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgPDGRVTRFVRH
|. . |.|||.||||| | ..||.| |||.. .|. ||..||.|| ||.|||||  . .. ||.. || . |.. |....| .... .      .|.|.|
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvth

WHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDP---IDVFGTVCEMRYERCQMVQNEQQYIFIHYC
.|| .|||.|.|.... ...| .. |..| ..| . |..|||||||||.|||| .. .|.    .     .|.. .|...|  |...|||..||.|....
fhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea

ILQVL
.|. |
llell
0043336 (Phosphotyrosine protein) phosphatases II 1052-1333 1.7e-86 285.4 In-house 2-275 (278) alignment 
Range on Protein: 1052-1333
Range on HMM: 2-275/278.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVgQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
....|...... . ...  ....|.  .... .  .   ..|| |..|||...|. |||||||||. .. .. |||||.||.|..  |.|||.||||| |
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPdheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRvtRFVRHWHYMAWPDFGAPSHPNGI
 ..||.| ||.... |. ||..||.|| ||.||||   . .. |||. || . |...| ...|...... | .    |.|.|.||..|||.|.|.... .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsll

IQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
..| ...|..|.  . | |..|||||||||.|||| ...||.    .  .|.. .|.|.|  |...||...||.|.....|.
ldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
DSPc_SM00195 1072-1335 2.1e-84 278.3 In-house 2-262 (263) alignment 
Range on Protein: 1072-1335
Range on HMM: 2-262/263.0
FSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
..||.. ...    ...  .| . |. |||..||. |||.||||..... || |||||||. | ......||.|||||.| ..||.| ||.... |. ||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFD-EFVIRDIRLEKSGPdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSphNAP
...|.|. ||..|||. .. .  .|.|.|..| ... . |...|...|.| |.  . ||.|....| .||| |.|.... .... |.....  .|  ..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
..|||||||||.|||..|| .|.. . .. .|.| .|.|.| .|..|||...||.||. .||...
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1072-1335 2.1e-84 278.3 In-house 2-262 (263) alignment 
Range on Protein: 1072-1335
Range on HMM: 2-262/263.0
FSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
..||.. ...    ...  .| . |. |||..||. |||.||||..... || |||||||. | ......||.|||||.| ..||.| ||.... |. ||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFD-EFVIRDIRLEKSGPdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSphNAP
...|.|. ||..|||. .. .  .|.|.|..| ... . |...|...|.| |.  . ||.|....| .||| |.|.... .... |.....  .|  ..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
..|||||||||.|||..|| .|.. . .. .|.| .|.|.| .|..|||...||.||. .||...
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1054-1337 2.4e-84 277.8 In-house 6-281 (288) alignment 
Range on Protein: 1054-1337
Range on HMM: 6-281/288.0
IEDFaDHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRD
|..  ..|  .||..   |||||. . ...  .|| |..|. | .|||. || .||. |||| . .. .| |||||.|. |  .....||.||||. | .
ispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn

HFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrvtRFVRHWHYMAWPDFGAPSHPNGIIQ
.||.. .|..   |. ||. ||.|. ||..|||| .. |..||...||.| .|| ..|| | . |||.. .    . . ...|.|||| | |   . ...
dfWelvyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrklllekkkte....leitqyqylaWpdhgvPeskaplle

FSRMFRHHLPHSphNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
. |.     .      | ||||||||||.||||..| |..     | |||.|||...| .| ..||...||.||. ..|.. . 
llrqvkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1060-1336 2.2e-82 271.4 In-house 5-277 (281) alignment 
Range on Protein: 1060-1336
Range on HMM: 5-277/281.0
HVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMT
|.. .|....  | |||. ....||...  ||. . |. |||..|| .||..|||... .. .  ||||||.|||... .|.||.|||.|.. ..|||| 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WEQQCPAIIALTKCVEKGRDKCHQYWPdHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFR
|||.  ||. .|. .|.|. |||.|||  .|  . |||. |. .||.|  ... | ..||... .   || |.. .|.|||| |.|. .. ...| .  .
weqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresge...treveqlaytaWPdhGvPattkellefrkevl

HHlPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS-SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.   .. ..|| ..||||||||.||.|..|||...  .   ..||  .| |.| ||  |||   || |..  .|..|.
kl.tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1050-1336 8.6e-80 263.2 In-house 3-284 (319) alignment 
Range on Protein: 1050-1336
Range on HMM: 3-284/319.0
RPVRIEDFADHVRLMSADSDFRFSEEYDMMRNvGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLP
............. . . ..  . .|. .... .| ...  .. ..|..|||..|| .||..||.||. ...|| |||||... |.  |..|||.|.|| 
teievqeLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

TTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHEnvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrV-TRFVRHWHYMAWPDFGAPSHP
.| . ||.| ||...  .. ||| |||.. |...|||...  .. || . ||.  |.| ....||.. |.|   .  | || | |..|..||| . | . 
ntiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkksse..vetRevkhfqyteWpdhdvPeka

NGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 ..... .  |.   . ... | .||||||||| |||| .|  |.  .    .||| || ..|  |  |||...||.||.. .|....
tslldllkrirksr.ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0040439 (Phosphotyrosine protein) phosphatases II 1090-1334 3.2e-79 261.3 In-house 5-245 (249) alignment 
Range on Protein: 1090-1334
Range on HMM: 5-245/249.0
ASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDhe
 ..|| |..|||...|. |||||||||  .. ...|||||.|..|. . |.|||.||||| | ..||.| ||... .|. ||..||.|| ||.||||.  
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

NVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISID
. .. |||. || . ....|....| ..|...      .| |.|..|  |||.|.|.... ...| .. |..| . | . |..|||||||||.|||| ..
ggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 .|.       .|.. .|...|  |...|||..||.|.....|. 
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 1096-1332 1.3e-78 259.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 1096-1332
Range on HMM: 1-234/235.0
NRPKNRFTNIPSYDHSRVKLsnpNNIEG-GDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVL
|. |||...|. ||..||||   .. ||  |||||||| |... ..|||.||||. | ..||.| |.... .|. ||...|||| ||.||||..|. .. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIEVTIV-AEK-EFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLphSPHNAPTIVHCSAGVGRSGTFISIDRLL
||||.|...  || . .|...|...|.|.. .   .| |...|| .||| |.|..|...... |.....   .....|..|||||||||.|||...| ||
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
.. . .. .||. .|.|.| .|..|||...||||.. .||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1096-1332 1.3e-78 259.0 In-house 1-234 (235) alignment 
Range on Protein: 1096-1332
Range on HMM: 1-234/235.0
NRPKNRFTNIPSYDHSRVKLsnpNNIEG-GDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVL
|. |||...|. ||..||||   .. ||  |||||||| |... ..|||.||||. | ..||.| |.... .|. ||...|||| ||.||||..|. .. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIEVTIV-AEK-EFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLphSPHNAPTIVHCSAGVGRSGTFISIDRLL
||||.|...  || . .|...|...|.|.. .   .| |...|| .||| |.|..|...... |.....   .....|..|||||||||.|||...| ||
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
.. . .. .||. .|.|.| .|..|||...||||.. .||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 1066-1335 4.9e-78 257.6 In-house 3-272 (278) alignment 
Range on Protein: 1066-1335
Range on HMM: 3-272/278.0
ADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKlsnpnnieggDYINANYVPGFssRREFIAAQGPLPTTRDHFWQMTWEQQCP
|... ... |..  .  |  ...  . .. |..|||...|. |||||||          |||||.|..|.  ...|||.|||||.| ..||.| ||....
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

AIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKS--GPDGRVTRFVRHWHYMAWPDFGAPSHP--NGIIQFSRMFRHH
.|. ||..||.|| ||.||||.  . .. |||..||.. |...|....|.....     . .  .|.|.|.||. |||.|.||.|  . .... .. |..
vivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirea

LP-----------HSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSsfGDPIDVFGTVCEMRYERCQ-MVQNEQQYIFIHYCILQVL
|            . ... |..|||||||||.||.. .. .|.    .. .|.. .|.|.|  |.. .|||..||.|.....|..|
lkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0042113 (Phosphotyrosine protein) phosphatases II 1092-1335 2.1e-77 255.1 In-house 5-243 (245) alignment 
Range on Protein: 1092-1335
Range on HMM: 5-243/245.0
ELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNV
.|| |..|||...|. |||.|||||.... .. |||||.||.|.   . |||.||||| | ..||.| ||... .|. ||...|.|| ||.||||.  . 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

PVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHsPHNAPTIVHCSAGVGRSGTFISIDRL
.. |||. || . |. .|....| .....       .|.|.|.||. |||.|.|.... ...| .. |..|   . | |..|||||||||.|||| ....
sltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylm

LQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
|.       .... .| |.|  |...||...||.|.....|. |
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRG_pd Subfamily PTPRG 1052-1337 1.2e-76 253.2 In-house 1-289 (563) alignment 
Range on Protein: 1052-1337
Range on HMM: 1-289/563.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQ--SVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGG-DYINANYVPGFSSRREFIAAQGPL
| ...|| ||  . ||.| .||||.. . .  . .   . .|. | |. ||| .|| .||.||||||.  ....  |||||||. |.   ..|||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEF-----DEFVIRDIRLEKSgPDGRVTRFVRHWHYMAWPDFG
..| | ||.| |||.   |. .|. ||.|| ||..|||   . .. || ..||...|. .      ..||....|.|   .    . ||..||  ||| |
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkk.kqcdteklvrqyhytkWPdhg

APSHPNGIIQFSRmfRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
.|.|.   ..| .  ..   .  .  |..|||||||||.||.| .| ||.     . ..|||..  .| .|  .||.| ||||.|  .|.....
vPehslpvLifvk..kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPRA_pd Subfamily PTPRA 1046-1334 1.4e-76 252.5 In-house 7-294 (330) alignment 
Range on Protein: 1046-1334
Range on HMM: 7-294/330.0
TN-KSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAA
.| |  |. .|.. . .|  |||   .| ||.. .    .  .. ...   |. |||. ||  ||.||| ||. . .|  ||||| .. |.  . .||||
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaa

QGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEkSGPDG---RVTRFVRHWHYMAWPD
|||.  | . ||.| |||.  .|. ||.  |. ..||.|||||.    | ||.| |..  |..  .. .|.. ..   ||.   . .| || .|. .|||
qGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPd

FGAPSHPNGIIQFSRMFRHHLPHSPHnaPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
.| |..| |.... .  ..  . |    | .|||||||||.|||| .| .|.       .|||..| ..|  |.|||| ..|| ||.  .|. 
vGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Ptp69D_pd Subfamily Ptp69D 1051-1334 1e-74 246.5 In-house 3-285 (307) alignment 
Range on Protein: 1051-1334
Range on HMM: 3-285/307.0
PVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPT
.. |.| .. ..    |.|| . .||... .  . .|  .||   |  |||. .| ..|. ||||.. |  |  |||||... |.  ...|||||.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHenVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSG---PDGRVTRFVRHWHYMAWPDFGAPSH
| . ||.| .||.   |. |..  || |.||..|||.     | |||| |..| |.. ....||.. . | .   ..   .| |  .||..|.|. .| .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PNGIIQFSRMFRHHLPHSphNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
..|.... .. |..  ..  ..| .|||||||||||.|...| |||     | .|.| ||...| .|  .||. .||.|..  .|. 
argllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1058-1337 1.2e-73 243.0 In-house 15-292 (298) alignment 
Range on Protein: 1058-1337
Range on HMM: 15-292/298.0
ADHVRLMSADSDFRFSEEYDMMRNVGV---GQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDH
   .  . . .  ....|.  ...|      ..  ... | |. |||...| ..|.||| |.. .. | .||||| .. ... |  |||.|.||..|   
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetved

FWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQF
||.| .|..  .|. ||. .|... |.|.||||...    ||.|.|.. ...|| ....| . ..|.  .   .| ||. |.. ||| |.|.. . ....
FWrmvteedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldl

SRMFRHhLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
 |  |   ..   |.| ||.|||||||||||| || .|.       .||| .|  .| .|...|| |.||.||.. .|..|. 
lrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
0037934 (Phosphotyrosine protein) phosphatases II 1091-1333 6.7e-73 240.5 In-house 5-240 (243) alignment 
Range on Protein: 1091-1333
Range on HMM: 5-240/243.0
SELPINRPKNRFTNIPSYDHSRVKLsnpnniEGGDYINANYVPGFssRReFIAAQGPLPTTRDH----FWQMTWEQQCPAIIALTKCVEKGRDKCHQYWP
. || |..|||...|. ||||||||      ||.||||||.....  .| .|| ||||| | ..    ||.| ||... .|. ||..||.|| ||.||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dhENVpvLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVtRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPH------SPHNAPTIVHCSAGVG
  ..|   |||..||.. |...|....| ..||  ..|. . |.|.|.||..|||.|.|..|. ...| .. | ..         ... |..||||||||
..gev..tygdftvtllseehlddytvrtlllenldlddlt.rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RSGTFISIDRLLQSSsfgDpIDVFGTVCEMRYERCQ-MVQNEQQYIFIHYCILQ
|.||.| .. .|.     . .|.. .|...|  |.. .||...||.|.....|.
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 1071-1337 5.5e-71 234.1 In-house 27-299 (306) alignment 
Range on Protein: 1071-1337
Range on HMM: 27-299/306.0
RFSEEYDMMRNVGVGQS--VAASELPINRPKNRFTNIPSYDHSRVKLSnPNNIEGGDYINANYVPG--FSSRREFIAAQGPLPTTRDHFWQMTWEQQCPA
 |.||.. ...  . .      .. | |. |||. ||  .||.||.|.  ... | |||||||. .   .|....||.|| |.||   ||.| |....  
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IIALTKCVEKGRDKCHQYWPDHENVPVlYGDIEVTIVAEKEFDEFVIRDIRLEKSgPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSP
|. .|| ||.|..|| .||||.|. .  ||.|.|| |.||. .....|.....|   ... .| |...|. .||| | |..|. ...| .  ...  .. 
ivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

--HNAPTIVHCSAGVGRSGTFISIDRLLQ---SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
  .. |..||||||.|| |||| || ||.   .. .  .||.  .|  .|  | ..|| |||| |... | . .. 
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN12_pd Subfamily PTPN12 1089-1336 5.5e-71 233.8 In-house 33-278 (290) alignment 
Range on Protein: 1089-1336
Range on HMM: 33-278/290.0
AASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDH
.|.| . |. |||. .|  ||.|||.||. .. || ||||||.. | ... |.||||||||.| | ||.| ||..   .. . . || |. ||..|||..
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

ENVPVLYGDIEVTIVAEKEFD-EFVIRDIRLEKSgpdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFIS
 . .. .|..|||  .|| .| .|.|| ...|..    . .| |. .||.|||| | || .. .... ...|..     ..|| .||||||||| || |.
geeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

ID---RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
||   .||..    . .|||  | |.| .|  .|| ..|| ... ......|
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN9_pd Subfamily PTPN9 1054-1333 6.2e-71 233.8 In-house 3-288 (297) alignment 
Range on Protein: 1054-1333
Range on HMM: 3-288/297.0
IEDFADHVRLMSADSdfrFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRD
||.. ..|. .        |.||  .||  |   . ||.|. |  |||.|..  ||..||.|.. .. |  ||||||.| |.  .. |||.||||. | .
ieelvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

HFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQ
 ||.| |||..  |.  |..||.|| || ||||..|.    .||..|. |  .| .....| . ....  . . .| | |. ...|||.| ||  . ...
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv..kteesrkvthfqflsWPdyGvPssaaslld

FSRMFRHHL-----------PHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
. .. |..               |.. | .||||||.||.||||..|  |.     . .||. ||  .|  |  ..| ..|| | . ..|.
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPRK_pd Subfamily PTPRK 1052-1348 1.1e-70 233.0 In-house 4-291 (314) alignment 
Range on Protein: 1052-1348
Range on HMM: 4-291/314.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVgvgqsVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
.|..|  ... |. .   . | |||. . .        |.    || |||...| .||.|||.|   ..    |||||... ..   ..||..||||. |
irvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqet

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVpvlYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGI
   ||.. ....| .|. ||. ||.|| || .|||.. .|   ||||.|..|  .   |.|.|  |.||.      .| ||......|||.. | . .|.
vkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

IQFSRMFRHHLPHspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ-VLQGSSPSPTSTSTG
... |   .. ..  .. ...|||||| ||.|||| || .|.     . .||| .| ..| ..  ||. |.||.||.  ||. .| | .  |.|    
lklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefka
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1067-1337 7.9e-70 230.7 In-house 31-294 (319) alignment 
Range on Protein: 1067-1337
Range on HMM: 31-294/319.0
DSDFRFSEEYDMMRNVGVG-QSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCP
|   ..  |.  . ..||     . ..|. |. |||..|| ..|...||| . . .|. ||||| .| |. ..  .|||||||. | . ||.| ||..| 
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

AIIALTkcvekgRDKCHQYWPDHENVPVLYGDIEVTIVAEKEfdEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHS
.|. ||      .||| |||| . ..    ....|. | | .  |.|.|||.| . |   .  | .. .|.. ||| | | .|  .... .  ||   . 
tivllt......kdkcsqywplkivikeerfkvkvdsveeta..eyvvrdielsedgke.kdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

PHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ-VLQG
 |.|. .|||||||||.|..| .| ||.     . .||. .| ..| .| ..||.  || ||.  .|.  | |
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1080-1337 4e-68 225.0 In-house 8-258 (284) alignment 
Range on Protein: 1080-1337
Range on HMM: 8-258/284.0
RNVGV-GQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTkcvekgR
 ..|| |   . ..|. |. |||...| ..|...||| .   .|. ||||| .. |. ..  .||.||||. | . ||.| ||..| .|. ||      .
cklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

DKCHQYWPDHENVPVLYGDIEVTIVAEKEfdEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAG
||| |||| . ..    ....|. | | |  |.|.|||.| . |   .  | .| .|.. ||| | | .|  .... .  ||   .  |.|. .||||||
dkcsqywplkivikeerfkvkvdsveese..eyvvrdielsedgke.kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

VGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ-VLQG
|||.|..| .| ||.     . .||. .| ..| .| ..||.  || ||.  .|.  | |
vgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1051-1336 5e-68 224.5 In-house 3-284 (305) alignment 
Range on Protein: 1051-1336
Range on HMM: 3-284/305.0
PVRIEDFADHVRLMSADSDFRFSEEYDMMRNVgvGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPT
.. ..|.| ... ....||  . ..|... .   ..|.   .   |. |||...|  .|..|..|.. .. .  |||||.|| |.... ..|.|||||..
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdGRVTRFVRHWHYMAWPDFGAPSHPNG
| . ||.. .| .   |. ||| || |.|||.||||. .. .. .|...|..  ||.. ....|.... .     . .| | ...   ||| | |  .  
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfats

IIQFSRMFRHHLPHSpHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.... .  ...  .. .. | .|||||||||.|.||..|  |.     . .|||. . ..| .| .|||. .|| |.|  . . ..
llslikrvqkdqkkd.kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN1_pd Subfamily PTPN1 1076-1333 3.8e-67 221.0 In-house 12-269 (290) alignment 
Range on Protein: 1076-1333
Range on HMM: 12-269/290.0
YDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVE
|  .|.     ......|| ||..||. ..  |||||.|| . .|    |||||. |     .|..| .||||| | |||||| |||.. |.. | |.||
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

KGRDKCHQYWPDHENVPVLY-G--DIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTI
|.. ||.|||| .|..  |      ..|....|.. .....| ..||.     . || . |.||..||||| |. |.  ..|    |.    |..  |..
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl..ktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpav

VHCSAGVGRSGTFISIDRLLQS-SSFGD--PIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
.|||||.||||||. .| .|      .|   .|.  ...|.|  |  ..|  .|  | .  ||.
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1092-1337 1.7e-66 219.0 In-house 5-244 (250) alignment 
Range on Protein: 1092-1337
Range on HMM: 5-244/250.0
ELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDkCHQYWP-DHen
. | |. |||...| ..|.||| | . .  .  ||||| .. |.. |. |||.||||..|  .||.| .|..  .|. ||. .|...  .||||| ..  
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..

vPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSpHNAPTIVHCSAGVGRSGTFISIDR
 .  |||. |..  ..|| ....| . | |    .   | ||. |...||| | | . . .... .  .   ... .||| ||.|||||||||.|| || 
.aekyGdvtvsllskeefadytkrklklskakkad..erivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaida

LLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
.|.       .|||  .  .| .| ..|. ..||.|..  ||. |. 
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN3_pd Subfamily PTPN3 1075-1336 2.5e-66 218.4 In-house 20-276 (280) alignment 
Range on Protein: 1075-1336
Range on HMM: 20-276/280.0
EYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYV----PGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
.....     | .. |. .| | .|||. .| .||. ||||.. ..    ||||||||    |. .    .||.||||..|  .||||.|||..  |. |
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TKCVEKGRDKCHQYWPDHENVpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGpdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
|  ||.|| |||||||..|.  . ||...|..  |.|  ..|.|.. |...    .  | . .  |.|||| | |.... ...| .  |.   .| .. |
ttlverGrvkChqyWPetede.leygefsvkcekedetksyvlrelvlkdke..tkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeeP

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
..||||||.||.| .| ..  |.     .|. .   | .||  |  .||...|| |.  .||.| .
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPN13_pd Subfamily PTPN13 1073-1336 4.1e-63 208.2 In-house 14-270 (273) alignment 
Range on Protein: 1073-1336
Range on HMM: 14-270/273.0
SEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNpnniEGGdYINANYVP--GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
.||.. .|..   ...  ..   |. |||. |.  ||..||||..    ||| ||||...       . |.||.|||||.| . |||| |||..  |. .
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgd....egg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TKCVEKGRDKCHQYWPDHENVPVLYGD-IEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSpHNA
|. .|||. |||.|||...| ..   . .||. .  .. |.||.|.. ...|  . . .| | | ....||| | ||... ..|| .  |.   .. ...
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds..esgesrevahlnfvkwPdhgvPssaaellqfvaevrrl..qt.dag

PTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
| .||||||.|||||.|.|| .|.  .   ..||  .| ..|  |  .|| ..||||..  ||.||.
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1050-1334 1.4e-62 206.4 In-house 4-278 (315) alignment 
Range on Protein: 1050-1334
Range on HMM: 4-278/315.0
RPVRIEDFADHVRLMSADSDFRFSEEYDMMRNvGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLP
.|. ....  .|    | .   | ..|. .   |  . .  .    |. |||. || .||.|||.|   .| .. ||.|||...|.. .| .||||||..
qpipldqlityvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

TTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHenvPVLYGDIEVTIVAEKEFDEFVIRDIrlekSGPDGRVTRFVRHWHYMAWPDFGAPSHPN
.. . ||.. .|...  |. ||. ||. . |. .||||.    |.|| | || . |. ..|. .| .    |   |   | |  .|| .||| | | .  
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswpdmgvpkyti

GIIQFSRMFRHHLPHSPhnAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 .... |  . |   |   .. .|||||||||.||||..| .|.     . |||.  .  .|  | .|||  .|| ||.  .|. 
plmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1090-1333 1.6e-62 206.1 In-house 22-266 (274) alignment 
Range on Protein: 1090-1333
Range on HMM: 22-266/274.0
ASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEG-GDYINANYVPGFSSR-REFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPD
  ... .  |||...|   ..||| |.. .. .   .||||||. |.. . . ..|.|||||.| . ||.| ...... |. |||  |. ..||..|.||
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

HENV--PVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPH-SPHNAPTIVHCSAGVGRSGT
.|..     |||.|....  .| ... .| . |...      .| | |. | .|||  .| ..| .... .  ..   . . . ||..||||||.|| | 
aedyeiserygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

FISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
||.|.  ..       .||...||..| .|  |||...|| .||  . .
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1096-1333 1.5e-61 202.7 In-house 20-262 (270) alignment 
Range on Protein: 1096-1333
Range on HMM: 20-262/270.0
NRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSS-RREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENV--P
..  ||...|    ..||.|.. .. .   |||||||.||.. ....|||.||||||  .||.| ||.. .||. .|. .||||.|| .||| . .    
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

VLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrvTRFVrHWHYMAWPDFGAPSHPN------GIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFI
. .|.|.|. ..|.  . .... .|||..|      | | |..| .||| |.|....       ...  |  |..  .  .. |..|||||||||.||.|
ledgkikvlalseekeegyiltrlrleekgee...rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

SIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
 .|  ..  .    .||   . |.| .|...||  .|| |..  ...
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1052-1336 1.6e-61 202.7 In-house 2-284 (290) alignment 
Range on Protein: 1052-1336
Range on HMM: 2-284/290.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIE--GGDYINANYVPGFSSRREFIAAQGPLP
.....|...|    |  . .| ... |. .    ..|     . |...|||.||  ||  |. | . .. .    .|||| |. |.. ....||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVlYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPN
 |  .||.. |......|. ||. .|.|..||.|||||. ..   || ...... |....|...| ......  .   .. | ...  .|.. |   .|.
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpq

G-IIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
. ......| . .  . . | . .||||..||||..|....  ..       ||||  . ..|  . ..|| .||| .|.. .|. |.
tillvieemyktq..rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1056-1344 1.8e-60 199.7 In-house 9-298 (325) alignment 
Range on Protein: 1056-1344
Range on HMM: 9-298/325.0
DFADHVRLMSADSDFRFSEEYDMMRNVGvGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHF
.. .||    |. .  |. |.... ... |..  .. .| |. |||| |. ..|.||| |   ..    |||||.|.  .  .  |.||| ||..| . .
nlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WQMTWEQQCPAIIaLTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDirLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFS
|..  . .|. .. ..  ...| |.| .|||..    . .| .|| ... .|. ..| |   |.  ....  || |. .....|.|.| . .|  .| . 
WrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrv..ldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RMFRHHLP----HSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL-QGSSPSPTS
..  .        .   .| .|||||||||.|.|||.  .|.       .|.|| |  .| .| .||.   |||.|. .. ...  | .  | |
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1071-1336 1.8e-60 199.4 In-house 20-278 (315) alignment 
Range on Protein: 1071-1336
Range on HMM: 20-278/315.0
RFSEEYDMMRNVGVGQSVAASElPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
 ||||.  . .  . .  .| | .|| .|||. ||  .|..||||   ...   ||||| |.... . . .||.||||... | ||.| ....  .|. .
lfseefhdlpdPdiyrqrvare.tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFvrhwHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
||  |  . || |||||..   | .| |.|...  .   . |.| . . ||    .||.|    ..  ||| |.. .   .... .  .    . ... .
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqf....qftewPdkGvdkqtssllklikevkad..ngkkefs

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 .|||||||||.| .||||  ..    .. .||| .| ..| .| ..|| |..| ||.  .|. |.
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1072-1335 5.7e-60 197.8 In-house 20-276 (515) alignment 
Range on Protein: 1072-1335
Range on HMM: 20-276/515.0
FSEEYDMMR-NVGVGQSVAASElpINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
||||.  .       |.||  |  || .|||. ||  || .||||   |.    ||.|| |.|.| . . .||.|||.... | ||.. ....  .|. .
fseefhdlpgpniypqtvaqee..infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
||  |  . || .||||.    | .| |.| .|. .   . ..| ... |.      .| |  .|.  ||| |.| | . .... .  .    |.  . |
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkad..hgqythp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
 |.|||||||| | .||||  .     .. .||| .|  .| .| ..|| ..|| ||.  .|. |
liihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1096-1332 2.9e-59 195.2 In-house 3-236 (237) alignment 
Range on Protein: 1096-1332
Range on HMM: 3-236/237.0
NRPKNRFTNIPSYDHSRVKLSNPNNieGGDYINANYVPGFSS-RREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVL
|. |||. || .|||||| |  . .  | |||||.|. ||    ...||||||| .. | |||| |...|  |. ||  .|. . |||.|||.  . |  
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaa

YGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQS
|| . |..  ..|| .. .| . | | .      |..  ... .||| | | .   ...| .   .. || .. .| |.||||||||.| |. || .|. 
ygvltvslkkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

SSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
.     .|..  |  .  .|  ..| ..||.|||  ||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1053-1336 3e-58 192.1 In-house 3-279 (287) alignment 
Range on Protein: 1053-1336
Range on HMM: 3-279/287.0
RIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQ-SVAASELPINRPKNRFTNIPSYDHSRVKLSnpnnIEGGDYINANYVPGFSSRREFIAAQGPLPTT
 .| |.. |.   | ..  |.. . .. .|.  . .|  .  . |..|||.|.|  .|  || |      |  ||||| .. |......||.|..|.  |
pvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRvTRFVRHWHYMAWPDFG-APSHPNG
   ||.. .... .||. |..  |. ...|.||||....  |..|. ..... |.  .....|........ .|  .. |. ... .|.. |  ...   
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtepqti

IIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.... .|.. .  . . |.. .||||..||||..|....  .. .     ||||  . ..|  . ..||  .||.||   .|. |.
llvieemyktq..rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1048-1336 1.7e-57 189.8 In-house 6-285 (297) alignment 
Range on Protein: 1048-1336
Range on HMM: 6-285/297.0
KSRPVRIEDFADHVRlMSADSDFRFSEEYDMMRNVGVGQSVAasELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSrrEFIAAQGP
. ||. . |||  |.  . ..|.   |  .. .     | ||  |  .| .|.|..||  || |||||   |.    ||.|| .|.|.    ..|. | |
errpiplsdfatlvq.knrhtdvfseeflclpeaniqpqtva..ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmP

LPTTRDHFWQMTWEQQCPAIIALTKCVEKGRdKCHQYWPDHENVPvlYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdgRVTRFVRHWHYMAWPDFGAPS-
 ..| . ||.| ...|  .|. |..  |. . || .||.|.  ..  .||. |.. . .|   |. |.. ..|. .  ...|.|. .... |||   .  
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgka..karrvvkqyqfveWPdkaverk

-HPNGIIQFSRMFRHHlpHSPHNA-PTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 . . ....    |..  .| ..  | .|||.||||| | ...||  .      . .|.||.|  .| || ..|| ..|| |..  .|..| 
dsassllklisevrkd..fsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPN23_pd Subfamily PTPN23 1085-1333 1.3e-54 180.0 In-house 34-278 (288) alignment 
Range on Protein: 1085-1333
Range on HMM: 34-278/288.0
GQSVAASELpiNRPKNRFTNIPSYDHSRVKLSnpnnIEGGDYINANYVPGFSSR-REFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQ
..|.|...|  .  |||...|  |||.||||      .  ||||| .| . |.   .|||.|.||..|   ||.| .||. . |. |..  |.|. |...
krsiaiakl..yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRH--HLPHSPHNAPTIVHCSAGVGR
||| ... .| .||..||.  ..| ...| |...||  ..|   .. |.| ....||..|.|. |. ..||    ..  .  . . ..| .|||||||||
YwPedkgetvkfgdlsvtlksvretethvervlkletldad..avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

SGTFISIDRLLQSSSFGDPI-DVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
.|.|  .   ..  . |. . |.   |  .| .|  |||...|. |    .|.
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPN14_pd Subfamily PTPN14 1074-1338 8.5e-52 171.0 In-house 27-299 (300) alignment 
Range on Protein: 1074-1338
Range on HMM: 27-299/300.0
EEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIeGGDYINANYVP--GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
 ||. . .      . ...|| | .|||| ..  |...||.||  ..    .||||  .     ...|..|.|||||..|   |||| |||.   |. ||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

KCVEKGRDKCHQYWPDH--ENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgPdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFR---HHLPHSP
.  |.|..|...|.|..  ..  | .|  .||    .. | .. . ..|.   |  .  | | |  |. ||| | |. ..| ... ....   ..  .. 
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.p.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

----HNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGS
    .. | .|||||||||.|  |  | |...   .. ||.  ..  .|  |  .||.  || |..  ... |. |
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_CG7180_pd Subfamily CG7180 1071-1332 1.1e-51 170.3 In-house 18-287 (296) alignment 
Range on Protein: 1071-1332
Range on HMM: 18-287/296.0
RFSEEYDMMRNVGVGQSVAASELpINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
 .  |. .  ..  |.  .. ..  || |||  ..  ||. || |.. .  |  ||||| || .|   .|.|  ..|   | | ||.. ..... |.. |
eyklelkltprleigdCagglrk.enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvL

TKCVEKGRdKCHQYWPDHEnvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKS--------GPDGRVTRFVRHWHYMAWPD-FGAPSHPNGIIQFSRMFRHH
||  .  . ....||| .      ||.|.| || ||.. ...|| ..| |          .    || |.. ..  |.     |.  |..|.. |. |  
tktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlw

LPHS---PHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
  .    |...|..|..| |..||| ...||  |.  .  . .|||. |  .| .| |.|.| ..| .|   .|
rekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1054-1355 4.3e-51 168.7 In-house 4-299 (439) alignment 
Range on Protein: 1054-1355
Range on HMM: 4-299/439.0
IEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASEL--PINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
 ..| .||  .  . .  |.|.....  .    .. || .    ...|||. .. ..||.|| | .   .    ||||||. |.   . .||.|||   |
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

RDHFWQMTWEQQCPAIIALTKCVEKGRdkchqYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGI
 |.||.. .|...  |. ||. ||  .     |||  ..  | |||| | .  . |. ..||| ... .    ..  | | ..||.||||   |..   .
tddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv

IQFSRMFRHHlPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGSSPSPTSTSTGAHH
..| |        .    | .|||||||||.|| |..|  |.     . .|. | |  .| .| ||||.  ||.||. ..|. ..    . |      . 
ldflrainsa.ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef

NAGF
||||
nagf
0051429 (Phosphotyrosine protein) phosphatases II 1121-1336 1.7e-50 167.4 In-house 1-226 (272) alignment 
Range on Protein: 1121-1336
Range on HMM: 1-226/272.0
IEGGDYINANYVPGFSS---RREFIAAQGPLPTTRDHFWQMtWEQQCPAIIALTKCVEKGRDKCHQYWP----------DHENVPVLYGDIEVTIVAEKE
.. ..||||..|.|. .   .. .....|||| | ..||.. .|... .|. |....|.||.||..|||          |..  ..|||.. ||.. |. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

FDEFVIRDIRLEKSGPDGRVtRFVRHWHYMAWPDFGAPSHPngIIQFSRMFRHhlphsphNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPID-----
.. ...| ..|..  . | . | |.|.||..|||.|.|...  .... .....       . | .||||||..|.||.. ...||.  |  . .|     
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
   ....| |.|  | ..||.|.||.|.. ..|..| 
nlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1095-1331 2.9e-50 165.7 In-house 37-273 (287) alignment 
Range on Protein: 1095-1331
Range on HMM: 37-273/287.0
INRPKNRFTNIPSYDHSRVKLSNPNNiEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVL
 .  |||....  .|..|| ||.  .  | ||||||||...    .|||||||...|   ||.. .|..  ..| .|. ||..| ||..|||.. .||..
aavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

YGDIEVTIVAEKEF-DEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPH---SPHNAPTIVHCSAGVGRSGTFISIDR
 |   |...  .    |. .| .|| .   ..| .| |.  ....||| ...    |.|.|    ..|.     .    | .||...|.||||.....  
vGGysvvlldydikePeygvralrlidl..etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

LLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCI
|..       .||  .|  .|  |  .||   |. ..   .
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1095-1333 6.2e-50 164.6 In-house 6-238 (239) alignment 
Range on Protein: 1095-1333
Range on HMM: 6-238/239.0
INRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFS-SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpv
.|. |||..|| .|||||| | . .|    |||||.|.  .  | . .||.|| . ..   ||.| |...   |. ||  .|  . ||||||||  .   
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...

LYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQ
 | .. ||.   . | ...|| . . . |      |.| ..|.  ||| | | .   .. . |   .     |   | ..||||||||.|.|. || .|.
kycnlrvtlrktevfadyiirtfvmsqvgqt..eeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlr

SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
 .     .|.|  |  .| .| .|||  .||.||| ..|.
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1094-1332 7.2e-50 164.4 In-house 6-238 (239) alignment 
Range on Protein: 1094-1332
Range on HMM: 6-238/239.0
PINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFS-SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvp
 .|. |||..|| .|||||| | . .|    |||||.|.  .  | . .||.|| . ..   ||.| |...   |. ||  .|  . ||||||||  .  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

vLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLL
  | .. ||.   . | ...|| . . . |      |.| ..|.  ||| | | .   .. . |   .     |   | ..||||||||.|.|. || .|
.kycnlrvtlrktevfadyiirtfvmsqvgqt..eeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidaml

QSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
. .     .|.|  |  .| .| .|||  .||.||| ..|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1076-1335 4.9e-49 161.7 In-house 12-267 (283) alignment 
Range on Protein: 1076-1335
Range on HMM: 12-267/283.0
YDMMRNVGVGQSVAASE-LPINRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYVP---GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
........| .  |  .    |..|||. .| ..|  ||.| . ..    ||||| ..|        ...|.||.||  |.  ||.| ....  ||. ||
revlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

KCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHspHNAPT
|  |  | || |||| .    . ||.  ||.  |   . |.|. . | ...   . | .. |. .  | ..|  .  | ...| ..      .  ...| 
klqedlrikCsqyWPkrGs..edyGeftvtlrkettsnsfiikelllrvnss.akstlllahyqvidWleygeqaiinslvkfnkvislqtes..kkgPi

IVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL-QVL
.||||.|.||...||..   ..       .||| .|  || .|  .||. .|| ..|  .| | |
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_PTPRN_pd Subfamily PTPRN 1078-1333 1.7e-48 159.8 In-house 37-290 (297) alignment 
Range on Protein: 1078-1333
Range on HMM: 37-290/297.0
MMRNVGVGQSVA-ASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRR-EFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVE
 . .    .|.. ... . |  ||| ... .||||||||.. .. |  |||||  .     |.  .||.||||..|  .|||| ||| .  |..||.  |
alcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrlee

KGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEF-DEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVH
.|  .|..||||. .   .|.  || .|.|. . |....| . |     . . || |  .|...||. |.|. .. ...| |       .    .| .||
egvkqckrywpdeGs..evyhiyevhlvsehiwcddylvrsfylknl..qtsetrtvtqfhflswpeegvPasaksllefrrkvnks..yrGrscpivvh

CSAGVGRSGTFISIDRLLQSSSFG-DPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
||.|.||.|..| || .|.    |   ||.  |.  .| .| ..|. ..|. |.  .. .
csdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0041856 (Phosphotyrosine protein) phosphatases II 1096-1336 5.5e-48 158.3 In-house 1-172 (182) alignment 
Range on Protein: 1096-1336
Range on HMM: 1-172/182.0
NRPKNRFTNIPSYDHSRvklsnpnnieGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTkcvekgrdkCHQYWPDHEnvpvly
|..|||...|. |||||          . ||||||.. |    ..|||.||||. |  .|..| .|... .|. ||         ...|||...      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdievtivaekefdefvirdirleksgpdgrvTRFVRHWHYMAWPDFGAPShPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRLLQSs
                                .| . ...|. |||.|.|. .. ...| .. ..      .. |..|||||||||.||.. .. ...  
................................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.

sfgdPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
     .... .|...|  |..||....||.|.....|..|.
....gvsleeavklvrsrRpgmvitpnqyfflqlallelll
0036282 (Phosphotyrosine protein) phosphatases II 1123-1329 1.5e-46 153.6 In-house 1-164 (174) alignment 
Range on Protein: 1123-1329
Range on HMM: 1-164/174.0
GGDYINANYVPGFSSRREFIAAQGPLPttrdhFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDhenvpvlygdievtivaekefdefvirdirleksg
| |||||... ..   ...|| ||||.     ||.| .|... ... |....|.|. ||..|||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

PDGRVTRFVRHWHYMAWPDFGAPSHPNgIIQFSRMFRHHLPHsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSfGDPIDVFGTVCEMRYERCQMVQNEQ
     .|.. ...|. |||.|.|. .  ...| .  ...| . ... |..|||||||||.||.. ....|.     ...|.. .| |.|. |..|||...
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYIFIHY
||.|..|
Qyrflyy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1071-1334 6.2e-44 145.0 In-house 21-235 (392) alignment 
Range on Protein: 1071-1334
Range on HMM: 21-235/392.0
RFSEEYDMMRNVGVGQSVAAsELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
 |.||.  . .  . .  .| . .|| .|||. ||  || .||||   ..|   ||.|| |.|.| . . .||.||| ... | ||.| ....  .|. .
lffeefhdlpgpdiypqtva.qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TKCVEKGrdkchqywpdhenvpvlygdievtivaekefdefvirdirleksgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
||  |                                                 |  .| |  .|.  ||| . | | . ...| .  . .  .  .  |
tklkegd..............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad..fGqythp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 |.||||||||.|  |||| ..  .     .|||  | ..| .|  ||| ..|| ||. ..|. 
liihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
0049772 (Phosphotyrosine protein) phosphatases II 1086-1336 8.4e-42 139.3 In-house 36-281 (314) alignment 
Range on Protein: 1086-1336
Range on HMM: 36-281/314.0
QSVAASELPINRPKNRFTNIPSYDhSRVKLsNPNNIEGGDYINANYVPGFssrREFIAAQGPLPTTRDHF----------WQMT--WEQQCPAIIA----
... .. |. || |||...|. .| .||.| .  ...| |||||.|| ||   . |||.||||. | . |          |.|.  .....  |      
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTKCVEKGRDKCHQYWPDHEnvpvlygdievtivaekefdefvirdirlEKSGPDGRVTRFVRHWHYMAWPDFGAPsHPNGII
                 |... ..|   . .......                             |   .. ...| . ..... .||..||  .. . 
vladelsrLdaAlgKtpllildgngneptaadlellk.............................eelydpelferlgikylripvpDgsap.lledfd

QFSRMFRHHlphsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFgDPIDVFGTVCEMRYeRC---QMVQNEQQYIFIHYCILQVLQ
.| .... .    . . |..|||.||.||.|||. .. |.    . .. ...  | ..|.  .    .... .||.||....|. |.
eflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1068-1336 1.8e-41 136.8 In-house 16-294 (301) alignment 
Range on Protein: 1068-1336
Range on HMM: 16-294/301.0
SdfrFSEEYDMMRNVGVgQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNN--IEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCP
.   |.|.|. ....   .|   .    |.. ||| ||  ||. |. |.. .|  .   .||||.|. |.|....|||||||.  |   ||.. |...  
k...feeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIR--LEKSGPDGRVTRFV-----------RHWHYMAWPDFGAPSHPNGII
.|. .|.  |. ..||.||||. |.    .| ..||.| |. . .||||..   ....  .|.. | .             ..   ||. |    |. ..
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

QFSRMFRHHlPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
|      |   ...  .| .||||..|.|||...|..  |        .|||. .  .|  .  .|.  .||..|.  | . ||
qviddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0046846 (Phosphotyrosine protein) phosphatases II 1125-1335 6.6e-41 135.3 In-house 13-173 (176) alignment 
Range on Protein: 1125-1335
Range on HMM: 13-173/176.0
DYINANYVPGFssrrEFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVlygdievtivaekefdefvirdirleksgpd
||||||.. |      .|| ||||| |  .|..| .|... |.. ||..||.|| ||..|||. |.. .                               
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................

grvtrfvrHWHYMAWPDFGAPSHpNGIIQFSRMFRHHLPHSphnAPTIVHCSAGVGRSGTFISIDRLLQsssfGDPIDVFGTVCEMRYERC-QMVQNEQQ
        ..... |||.|.|.. . .... .. | .| .     |..||||||.||.||.. .. |      .  ..|. .....|  |. ..||...|
........qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YIFIHYCILQVL
| |.....|..|
yrflyefellll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1087-1333 7.4e-41 135.1 In-house 32-275 (307) alignment 
Range on Protein: 1087-1333
Range on HMM: 32-275/307.0
SVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNieGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWP
.|..  .  |  |||.....  |..|. .  .      ||| |||.      . ||.||||| .|. .|| |. ...  ..| | |..| .. ||.||||
gvtveafsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywp

DHENVPVLYGDIEVTIVA------EKEFDEFVIRDIRLEKSGpdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVG
  |     .|.   ||        .   || .|    |.     .. .| ..|. .  ||| |.|    . | .    |       .. | .||||||||
leegqklvfgeapntisvanlgakklapdedlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvvvhcsaGvG

RSGTFISIDRLLQSSSFGDP-IDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
|||| ..|  . .    |    |.   | |.| .|   .|.| ||...|  .|.
rsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0043147 (Phosphotyrosine protein) phosphatases II 1122-1329 5.9e-40 132.1 In-house 3-155 (172) alignment 
Range on Protein: 1122-1329
Range on HMM: 3-155/172.0
EGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCvekgrdkchqywpdhenvpvlygdievtivaekefdefvirdirlekS
|| |||||.|...    ..||| ||||. | ..||.| .|... .|. ||..                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

GPDGRVTRFVRHWHYMAWPDFGAPsHPNGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLqsssfgDPIDVFGTVCEMRYERCQMVQNE
 .   ..|.. ...|. |||.|.| ... ...| .  ...| .   . |..|||||||||.||.. .. .|        .... .|...|  |...|||.
ydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

QQYIFIHY
.||.|..|
sqyrflyy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1098-1333 7.4e-40 131.4 In-house 58-281 (290) alignment 
Range on Protein: 1098-1333
Range on HMM: 58-281/290.0
PKNRFTNIPSYDHSRVKLSNPNNiegGDYINANYVPGFSSrrEFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGD
 |||. ...  | .|| |..  .   |||. |||| |  .   || .||.|  |   .|.|  ...  ||. | . .|.|. ||.||.|..|   . .|.
kknrykdvvcndktrvilkdGyd...GdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

IEVTIVAEKEFDEFVIRDIRLEKSGPDGRvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSF
| |.   |.. |. .|. .   .   .|.    ..|.. ..|||   .     ...  |. |.       . | .||||||.||.|||..|.  ||    
itvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglqilld

GDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
|  .|. ..|  .|  | . || . ||. .   .|.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1087-1333 6.2e-39 128.3 In-house 28-267 (281) alignment 
Range on Protein: 1087-1333
Range on HMM: 28-267/281.0
SVAASELPINRPKNRFTNIPSYDHSRVKLSN-PNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYW
 ... . |.|  |||..|||  | |||.|     | .  ||| |||.     .| .| .|||   ||  ||.| |...  ||. | . .|  |.|| .|.
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGpdgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTF
|    . . .  . |.         .|   . |   |     ||.. || .  |||.  |   . ...  |  |       . .| ..|||||||||||.
prnahcclqfdklsvsyedstvnkslvttrlnlsyeg....etrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtl

ISIDRLLQS--SSFGDPiDVFGTVCEMRY-ERCQMVQNEQQYIFIHYCILQ
....  |||  | |  | |.   |  .|   |.  ||  |||..|   .|.
maveialqsihshftlp.dikqivshlrvtgraasvqtlqqymliwkvlld
0049260 (Phosphotyrosine protein) phosphatases II 1132-1329 4.4e-38 125.7 In-house 2-144 (152) alignment 
Range on Protein: 1132-1329
Range on HMM: 2-144/152.0
VPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWpdhenvpvlygdievtivaekefdefvirdirleksgpdgrvtrfv
..|.   .||||.|||.| | ..||.| .|... .|. ||...|.|..||.||.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

rHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLqsssfgDPIDVFGTVCEMRYERCQMVQNEQQYIFIHY
 ..... |||.|.|...  .... .. ...      . |..|||||||||.||.. .. .|        .... .|  .|  | ..|.|..|..|...
.qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_ptpA1_pd Subfamily ptpA1 1073-1287 5.4e-38 125.8 In-house 24-248 (418) alignment 
Range on Protein: 1073-1287
Range on HMM: 24-248/418.0
SEEYDMMRNvGVGQS-VAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSsRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
 ||. .. .  || |  .  .   |  |||.|||   .|.||.| . .. || |||||||. |    ..||..||||| |   ||.| ||..|  |. |.
keefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmls

KCVEKGRDKCHQYWPDHE---------NVPVLYGD--IEVTIVAEKEFDEFVIRDIRLEKSGPdgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMF--
.  |. | || .|||..          |   ..|   .|.  | .    | . |.|||   |     || . ...|  |||.  | | . . |. .    
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfege....trditqyqyegwpdhnipdhtqpfrqllhsitn

--RHHLPHSPHNAPTIVHCSAGVGRSGTFIS
   . .| | .| | ||||||||||.||| .
rqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1067-1332 7e-37 121.9 In-house 3-256 (267) alignment 
Range on Protein: 1067-1332
Range on HMM: 3-256/267.0
DSDFRFSEEYDMMRNVGVGQSVAASELPI-NRPKNRFTNIPSYDHSRVKLSNPNNIeggdYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCP
|..  . .|.......   .|  .  ..  |. .||. .   ||..|| |.. ..     |||| || |.  .. ||. |.||  |  .|...  .|..|
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

AIIALTKCvekGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpdGRVTRFVRHWHYMAWpDFGAPSHPNGIIQFSRMFRHHLPHs
 |. |||    . |. ...|| .      | |. |    ||| ... |  . |.        .. |  ..|  | .  .  .|     |  . . .|   
vivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk...nesahnvtlyyykkw.nintnnkpylkplfgilaknqlen.

pHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
  | | .|.||.||||||||. ||  |.     .  |.|  . ..|  |  .|.  ..||.||  . 
.gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1093-1333 5.3e-36 118.8 In-house 52-287 (305) alignment 
Range on Protein: 1093-1333
Range on HMM: 52-287/305.0
LPINRPKNRFTNIPSYDHSRVKLSNPNnieGGDYINANYVPG-FSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDH--E
  |.  |||....|  |.| |||..|.     ||| ||||   .   . ||.|||||  | |.|| |  ...   |. | | || |. || ||||    |
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

NVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISID
.. .  | .   .   | ..     .| | .    |  .  ||| ..  ||| | |      ...    |        . | .||||||.||.|| ..|.
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg......skvpivvhcsagigrtgtivaie

RLLQSSSFGDPIDVF-GTVCEMRYERCQMVQNEQQYIFIHYCILQ
 .|.  .   |   .   |  .| .|.  .||. ||.|||  .|.
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1092-1335 3.2e-35 116.3 In-house 44-287 (305) alignment 
Range on Protein: 1092-1335
Range on HMM: 44-287/305.0
ELPINRPKNRFTNIPSYDHSRVKLSNPNNiegGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENV
    .. |||. ..   |. |||| .|      .|| ||||   .  . || .| ||  |   || | ....  ||. | . .|||  ||..|.. ... 
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

PVLYG--DIEVTIVAEK----EF---DEFVIRDIRLEKSGPdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRhhlphsPHNAPTIVHCSAGVGRS
 . .   .  ...  |     .|    . ....  |   || |  .| | |.|.. ||| | |.  . |...    |      |   |..||||||.||.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrt

GTFISIDRLLQSSSFGDPIDVFGT-VCEMRYERCQMVQNEQQYIFIHYCILQVL
|. . .. .|.    |. |.     .  .| .| . .| ..||.|.|  ||. .
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0044763 (Phosphotyrosine protein) phosphatases II 1108-1337 2.2e-34 114.0 In-house 2-173 (178) alignment 
Range on Protein: 1108-1337
Range on HMM: 2-173/178.0
YDHSRVKLSNPNNIEGGDYINANYVPGFssrrEFIAAQGPlpttrDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpvlygdievtivaeke
.|..||.|||. ..|..|||||... ..     ......|      ..... .|. . .|. ||. .| |. ||..|||. ..                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

fdefvirdirleksgpdgrvtrfvRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSssfgdPIDVFGTV
                         ..... .||.|.|. .  . .| .. ...|.  ... |..||||||||||||.. .. ...       ....  .
........................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

CEMRYERCqMVQNEQQYIFIHYCILQVLQG
 ..|  |. .|.|. |. ..... |..|. 
elvrerRp.ivpnpgqlrqLyefelrllke
0051082 (Phosphotyrosine protein) phosphatases II 1124-1332 1e-33 111.4 In-house 3-150 (151) alignment 
Range on Protein: 1124-1332
Range on HMM: 3-150/151.0
GDYINANYVPGFssrreFIAAQGPLPttrdHFWQMTWEQQCPAIIALTKCVEKGrdKCHQYWPDHEnvpvlygdievtivaekefdefvirdirleksgp
 ||||..|| |.     ... .|||.    .|... .|... .|. |.. .| |  .|..|.|...                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

dgrvtRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphsPHNAPTIVHCSAGVGRSGTFISIDRLLQSssfgdpIDVFGTVCEMRYERCQMVQNEQQ
     . |.|.... |||.| | ... ...| .....     . | |..||||||.||.||.. ....|.       .... .. |.|  |. .|| .||
.....ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YIFIHYCIL
..|.....|
flfqlfall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1096-1335 1.1e-33 111.6 In-house 43-271 (288) alignment 
Range on Protein: 1096-1335
Range on HMM: 43-271/288.0
NRPKNRFTNIPSYDHSRVKLSnpnnIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLY
|  ..|..|.|  | .|||||     .   ||.|| |.    .| .| || || .| . .|.|  |..   |. |.. .|||..|  .|.| .    . .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDIeVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFrhhlphSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS
| .  |.| .|  |   .  . | .    |  . .|.. |.  |.| | |      ...  ..        .. | .||.||||||.||.| |   |.| 
grl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialesl

SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
   | . .   . ..| || . .| |.||...| |.|. |
rlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1074-1254 2.5e-33 110.2 In-house 11-189 (297) alignment 
Range on Protein: 1074-1254
Range on HMM: 11-189/297.0
EEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNpnNIEGGDYINANYV--PGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
.|.|.. .   |.| ...  .    |||...| ..| .|||| .   | . |||||.||  |   .   .| ||||| .| | ||.. .||.  .|. ..
aekdllldeargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmva

KCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAE--KEFDEFVIRDIRLEKSgpdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQF
|  | |||||  |||. ..     ||. |  ...   |||  .. ...|         .| |||  ...||| | ||  . . .|
klqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrf
PTPc_DSPc_SM00012 1231-1332 4e-33 109.1 In-house 2-104 (105) alignment 
Range on Protein: 1231-1332
Range on HMM: 2-104/105.0
VRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFG-DPIDVFGTVCEMRYERCQMVQNEQQYIFIHY
|.| ||..|||.|.|.... |... | ....  .| ...|..|||||||||.|||. .| |||. . . . .|.| .|.|.| .| .|||.|.||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CIL
..|
all
subfamily_egg_pd Subfamily egg 1095-1334 9e-32 105.0 In-house 39-269 (307) alignment 
Range on Protein: 1095-1334
Range on HMM: 39-269/307.0
INRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKgrDKCHQYWPDHENVPVL
 |. | |   ..  | |||||  ..    .|.| ||.| |     ||| || ||  | | ||.| ...... |. ||  .|   ..|. |||  |. .. 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

Y--GDIEVTIVA--EKEFDEFVIRDIRLekSGPDgRVTRFVRHWHYmAWPDFGAPSHPNGIIqfsRMFRHHlphsphNAPTIVHCSAGVGRSGTFISIDR
.  | .... .   .|    | .  ..|   |.| .  ||. || .  .   .    |  ..   |. |.         |..|..  || ...|...|. 
tvpGslrienlkvdskadplfrvtklkl..vGgd.deerflehwqg.dvnnssdvysplrvl...rklrnl......skpvvvqdilGvskaatlvaiei

LLQSSSFGdPID---VFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 | |   | ||    |  .|  .| .|   |.   .|.|..  .| .
allsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1098-1337 3.8e-31 102.8 In-house 54-292 (310) alignment 
Range on Protein: 1098-1337
Range on HMM: 54-292/310.0
PKNRFTNIPSYDHSRVKLSNPNnIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVLYGD
 |||....   | |||||   .    .||| ||||     |  || .||||  |   ||.| ..... .|. | | .|.|| ||  |||    |   || 
hknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtetygc

IEVTIVAEKEfDEFVIRDIRLEKS--------GPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQfSRMfrhhLPHSPHnAPTIVHCSAGVGRSGTFISID
| || ..|   .|| | .. .            |       |   ..  ||| | |      .   |.    |    |  | .||||||..| .. ....
irvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrl....laqvrh.gpcvvhcsagkdrlyvvvalk

RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
  .. .  |. .|.   . |.. .| . .|.| ||..|..  .   .|
lkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarg
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1094-1327 1.3e-28 94.6 In-house 48-273 (301) alignment 
Range on Protein: 1094-1327
Range on HMM: 48-273/301.0
PINRPKNRFTNIPSYDHSRVKLS-NPNNIEggdyINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVP
 ... |.|. ..|   .. |..  . . .     | ||..|     . |||.||||. |.. || |    .   |. |.. |||  .||..| | . .  
ylpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

VLYGDIEVTIVAEKEF--DEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphSphNAPTIVHCSAGVGRSGTFISIDR
.  |  ...|. ..    .. . | ...| |  .   || | |. |. |.| | |     . ..  . ..    |  . | .||||||.||| .||. . 
ldigrfkikiknkelilnkkiskrtlevedstgk.fatrtvthyqysewtdrgvPkshaelfdlmelvkk....s..ekPivvhcsaGiGrsvafigtey

LLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFI
| .       |..  .. ..| .| . ||...|  ..
lareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1096-1335 9.9e-28 91.9 In-house 35-270 (285) alignment 
Range on Protein: 1096-1335
Range on HMM: 35-270/285.0
NRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYV--PGfSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPV
|   ||....   . .|| | | .     ||| |...  ||   .  .|..||||| |   ||.| ....   .. |   .| | .||  |.|..    |
npdlnryadvrcieetrvvlknhdr....dyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

LYGDIEVTIVAEKE--FDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlpHSPHNAPTIVHCSAGVGRSGTFISIDRL
 .|  |.|.   ||      ..  . . ..        .. | .   |||  ||     .|.. .  ..     |.. |  |||||||||. ||. ||  
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk...vnpkekpicvhcsagvgrtatfvgidya

LQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
         |...  | |||  | | ||.  |..|..  ... .
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_CG42327_pd Subfamily CG42327 1086-1253 4.8e-27 89.4 In-house 16-185 (319) alignment 
Range on Protein: 1086-1253
Range on HMM: 16-185/319.0
QSVAAS-ELPI-NRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFS-SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCH
| .| . |.|.  ..|.|. |.    ..|| | .  . .   |..|.|| |.  ..  .|||| .|  .   ||.. ||||   |. ||.  |.| ..| 
qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvca

QYWPDHENVP--VLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYmAWPDFGAPSHPNGIIQ
.|.| .|  .   ||||| ||.   .  |...|  . | .   |.  .| . |. |  |.. . |.... .| 
eylPtketldntslyGdilvtlkgrevkdryaistlllkrv..dkeesrelthywy.kwleaevPaeeaalia
0048076 (Phosphotyrosine protein) phosphatases II 1226-1334 4.9e-24 80.1 In-house 42-142 (145) alignment 
Range on Protein: 1226-1334
Range on HMM: 42-142/145.0
RVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHsphNAPTIVHCSAGVGRSGTFISIDRLLQsssfgDPIDVFGTVCEMRYERCQMVQNEQQYI
 ..|.. ...|. |||.|.|. .. ...| .. ...|..   . |..|||||||||.||.. .. .|.       .... .. ..|  | ..|.|..|..
llerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlr

FIHYCILQV
|.....|..
flyefelel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1072-1336 9.2e-24 78.7 In-house 21-277 (312) alignment 
Range on Protein: 1072-1336
Range on HMM: 21-277/312.0
FSEEYDMMRNVgVGQSVAASELPInRPKNRFTNIPSYDHSRVKLSNPNNIeggdYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
.. ||  . |. | .|  .. | . .  ||. ||  .|  |  |.  .|.    || ||.|   .    |...||||  |  ||||..    . .|| |.
ltkeykavgni.vsdsectaflkf.kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

KCVEKGRDKCHQYWPDHEN------VPVlYGDIE-VTIVAEKEFDEFVIRDIRLEKSgPDGRVTRfVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlph
  || | .|| .|  |           | | .      .  |  |    | ...      |. .. . |. . .||| | |   .   ..    ..    
gfvedgsekcakyisdivgfvdledhrv.yteycteieiggkskdkithrvlkvvvk.atgqesk.lnhyqwaswpdhgmpdscdtalrllsavkk....

spHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
   . | | ||||||||.||.. |. .. .       .|  .   .| .|.. |.   ||..   |.|..| 
..dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
0048179 (Phosphotyrosine protein) phosphatases II 1222-1329 1.4e-23 78.7 In-house 40-139 (144) alignment 
Range on Protein: 1222-1329
Range on HMM: 40-139/144.0
GPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPhspHNAPTIVHCSAGVGRSGTFISIDRLLqssSFGdpIDVFGTVCEMRYERCQMVQNE
 .   ..|.. ..... |||.|.|.... ...| ......|.   .. |..|||||||||.||.. .....    .|  .... .. ..|  |...|.|.
yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpgavpnp

QQYIFIHY
.|..|...
gqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1099-1188 1.1e-21 71.9 In-house 50-153 (350) alignment 
Range on Protein: 1099-1188
Range on HMM: 50-153/350.0
KNRFTNIPSYDHSRVKLS--------NPNNIEGGDYINANYV--P--GFSSRREF--IAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQY
|||..||  |.||||||             ... |||||||.  .  . .   .|  ||.|.||| | | |...  . . . |..||. || ...||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPDH
|.. 
Wqeg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1227-1335 3.9e-19 63.3 In-house 87-194 (440) alignment 
Range on Protein: 1227-1335
Range on HMM: 87-194/440.0
VTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIF
 .| ....|| .||| | |     .... .   .   .   |.| .||||||.||.|  |..| .|. .   | ||.|  .  || .| ||||  .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesq.ekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHYCILQVL
.| ..|. |
vheavlegl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1137-1328 6.4e-19 62.9 In-house 3-197 (199) alignment 
Range on Protein: 1137-1328
Range on HMM: 3-197/199.0
SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHY
..| .||.| ||  |   |||| ||     |. .     .       |||  |.    || . ||  .     ...|  . | ..      || . |. .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

MAWPDFGAPSHP--NGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS--SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIH
 .| .  .|      |..  ||   ..     ..|| ||||| | | .| |...|  ..|   |    .|.|     .|  || ..   |.| ||.
tswkekttpnvalfvgfvvasrevskky.eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1138-1328 6.7e-19 62.8 In-house 3-196 (198) alignment 
Range on Protein: 1138-1328
Range on HMM: 3-196/198.0
RREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYM
.| .||.| ||  |   |||| ||     |. .     .       |||  |.    || . ||  .     ...|  . | ..      || . |. . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDFGAPSHP--NGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS--SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIH
.| .  .|      |..  ||   ..     ..|| ||||| | | .| |...|  ..|   |    .|.|     .|  || ..   |.| ||.
swkekttpnvalfvgfvvasrevskky.eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1147-1335 1.4e-18 61.4 In-house 99-288 (302) alignment 
Range on Protein: 1147-1335
Range on HMM: 99-288/302.0
PLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIV-AEKEFDEF------VIRDIRLEKSGPDGRVTRFVRHWHYMAW
|   |.. .| .  . .   .. |.. ||..  || .|. |. .  . .|   |. |  .....||      ..  . .. .    .| . |   .. ||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
|| ||| ...  ..  .          .    .|||||||||.||...|   .|  |  .  |.   |. .|  |   ||.||| |..  |. . |
pdhGapkeaytaldilkfces......ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1087-1331 9.7e-18 58.8 In-house 38-275 (303) alignment 
Range on Protein: 1087-1331
Range on HMM: 38-275/303.0
SVAASELPINRPKNRFTNIPSYDHSRVKLSNpnniegGDYINANYVPgFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWP
||.  ..  |  ||||...   |||.||||.        || |.|.  . |..  | .| ||. |   ||||  ||.   .. |    |  .   .  .|
svsknqfvknmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

DHENVpvLygDIEVTIVAEKEFDEFVIRDIRLEK--SGPDGRVTRFVRHWHYMAWPDFGAPSH--PNGIIQFSRMfRHHLPHSPHNAPTIVHCSAGVGRS
  ..   |  ..|   .   || .  . |    |  |  .|    |.   || |||    ||.  |. . |  .. .  | .  .. ||.    .|.||.
rnqdf..l..kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwql.qsvlrkysdstptvymslsgcgra

GTFISIDRLLQS-SSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCI
|||  ..    |  |    .|.   .  .|  | . |||  |. ...  .
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1151-1335 6.2e-17 56.5 In-house 40-221 (255) alignment 
Range on Protein: 1151-1335
Range on HMM: 40-221/255.0
TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAekEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNG
| |.|.|.   ..   .. |.   |.|..||..|.|   .    . |..||        . |.| ...     . . |. |.|..|  |..  ||  .. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

IIQFSRMFRHhlphSphnAPTIVHCSAGVGRSGTFISIDRLLQ------SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
| .  .. |.    |    . .||||.|.||| .|. .. . |        .    .|    . |.| .| . ...  |  |  . .|...
ilnilkvvrd....s...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1103-1335 3.8e-15 50.8 In-house 25-259 (290) alignment 
Range on Protein: 1103-1335
Range on HMM: 25-259/290.0
TNIPSYDHSRVKLSNPNNIEGGDYINANYVpGFSSRREFIAAQGPLPTT-------RDHFWQMTWEQQCPAIIALTKCVEKGRD----KCHQYWPDHENV
...|   ..|| | .  .    ||| ||.|  ...  ..|. | |.  .         .|| |  . .   .. | .  || ..     | .| |.... 
levpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

PVLYGDIEVTIVAEKEFDEFVIRDIRLEKsgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRL
 . .....|      . |.. .| . ..    |...   | |  .  | .  .. ..  ...  .. .       ...| ||||  |. || .. .|.  
elkfkgltvkCkskekeddvetRelvvkf...ddeeeftvtHsllkgWnklnvqedtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilg

LQSSS-FGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
 |      . . .   . ..| .| ......... |. . |.  .
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1096-1335 1.3e-14 48.3 In-house 51-285 (302) alignment 
Range on Protein: 1096-1335
Range on HMM: 51-285/302.0
NRPKNRFTNIPSYDHSRVKLSNpnniEGGDYINANYV--PGFSsrREFIAAQGPLPTTR---DHFWQMTWEQQCPAIIALTKCVEKGRdKCHQYWPDHEN
|  ||. ...| .|. .|||..    |  .|.||  |  | ..  |. | || |  ..    ..||.| .....  .  | .  |  .   ....| . .
nlkknqsedvpildsnlvklea....epdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

VPVLYGDIEVTIVAEKEFDEFViRDIRLEKSgPDG-RVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFrhHLPHSPHNAPTIVHCSAGVGRSGTFISID
  . ||.. | .   .. .| .     .|   |.|   . ..   .   |..   | . . .|.       .  ... ...|..    |.|| |.|..  
dykeygkmfvNnrkVekaeeek.tryviEvl.PegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltla

RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
  ...   |.   .  .|  .| .|...|.. .||.... ..|  .
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1098-1188 1.3e-14 48.4 In-house 50-156 (349) alignment 
Range on Protein: 1098-1188
Range on HMM: 50-156/349.0
PKNRFTNIPSYDHSRVKLSN----PNNIE----------GGDYINANYV--PGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKC
 |||. .|  |.|||||| .    .. |.            |||||||.  . .|  . .|| | |||.| | |...   .. . ...|..  |.. .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPDH
..|| . 
diywqel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1231-1333 5.4e-14 46.7 In-house 217-342 (350) alignment 
Range on Protein: 1231-1333
Range on HMM: 217-342/350.0
VRHWHYMAWPDFGAPSHPNGIIQFSR--------MFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQS-----------------SSFGDPIdvFG
| . ..  |.| .   .|. |.|           .| .   .. . .| .||||||||| ||....| ||.                  .   |.|  . 
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli..si

TVCEMRYERCQMVQNEQQYIFIHYCILQ
.| |.|  | .|||| .|.|||. ..| 
ivnelrkqrismvqnldqfifiYeallf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1050-1146 5.6e-14 46.1 In-house 3-95 (95) alignment 
Range on Protein: 1050-1146
Range on HMM: 3-95/95.0
RPVRIEDFADHVRLMSADSDFRFSEEYDMMR-NVGVGQSVAASElpINRPKNRFTNIPSYDHSRVKLSNPNNiegGDYINANYVPGFSSRREFIAAQG
.|. .  |  ||  | ..||  | .|.  .    |   .| .||   | ||||| ||  || .|| |.   .    ||||| .| |.. .  .|||||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsse..anipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_eak_pd Subfamily eak 1100-1246 1.6e-13 44.8 In-house 56-196 (332) alignment 
Range on Protein: 1100-1246
Range on HMM: 56-196/332.0
NrFTNIPSYDHSRVKLSNPNnIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIE
|   .|  ||.  |.|..    .   ||||  .      |..| .  .  .    ||||  ||. |||. | . ||.. .|  .|.||.    . .| ..
n.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTIVAEKEFDEFVIRDIRLEKsgpdGRVTRFVRHWHYMAWPDFGAPS
|.     . . .  | . |.|    |  |  | |...  | ..  | 
verkefvkrniletrllelsk....GnethrvlhykvfGwtettlpk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1042-1219 2.3e-13 44.3 In-house 36-212 (244) alignment 
Range on Protein: 1042-1219
Range on HMM: 36-212/244.0
TGANTNKSRPVRIEDFADHVRLMSA----DSDFRFSEEYDMMRNVGV-GQSVAA-SELPINRPKNRFTNIPSYDHSRVKLSNPNniEGGDYINANYVPGF
  ||. |.| . |  | .   ..|.     ||.  ..  .  .|.     ||   .  | |  |||      .| .|| ||. .   |  |||| .|  .
lsanatknryinilpfdetrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgs..mgntyinasfvgcl

SSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKcVEKGrdkcHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLE
    |.| .| ||  |   ||.|  |.    .. |   ||.      .|||| | .     || ||.    || .    .. .|
grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeeditvtltdrdefknikasnleie
fn3 Fibronectin type III domain 642-730 2.7e-13 43.0 Pfam-A 2-85 (85) alignment 
Range on Protein: 642-730
Range on HMM: 2-85/85.0
AVQDLKVEPLNSYSVMLTWLPPALPNGILTHYAVNVTKIGSDEtrtidVGVSSNRSDHTVQVVIDELFGGHTYSFSVRAVTEAGFGENS
|...|.|.. .| |..|.| ||. ..| .|.| | . . |. |     . .. ... .| .|.. .|  | .|.|.|.||..|| |. |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1272-1335 8.9e-13 42.4 In-house 2-65 (69) alignment 
Range on Protein: 1272-1335
Range on HMM: 2-65/69.0
IVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
.||||.| ||.||||.|   .        .|.|  |  ||  |  || ||..|||||  . . |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_hpo-7_pd Subfamily hpo-7 1151-1335 1.3e-12 42.2 In-house 46-227 (263) alignment 
Range on Protein: 1151-1335
Range on HMM: 46-227/263.0
TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEfdEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNG
| | |.|.   ..   .. |.   |.|..|| .|.|   .    . ...|.    ..  . ... . | .   . . |. |.|. |  |..  .|  .. 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

IIQFSRMFRHhlphSphnAPTIVHCSAGVGRSGTFISIDRLLQ------SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
|..  .. |.    |    . .||||.|.|||  |  .. . |        .    .|    . |.| .| . ...  |  |  . .|...
ilnilkvarn....s...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1272-1335 3.6e-12 40.4 In-house 1-64 (69) alignment 
Range on Protein: 1272-1335
Range on HMM: 1-64/69.0
IVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
.||||.| ||.||||.|   .        .|.|  |  ||  |  || || .|.|||  . . |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1049-1138 1.3e-11 38.6 In-house 3-89 (440) alignment 
Range on Protein: 1049-1138
Range on HMM: 3-89/440.0
SRPVRIEDFADHVRLMSadSDFRFSEEYDMMrNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSR
 ||. . ||||.|.         | .|. ..   |. |    . || |. |||. || .|||||| | . . .   ||||| |. |  ||
qrpiivadfadyvqnnr..rsrafedewsll.psglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_CG42327_pd Subfamily CG42327 1267-1329 3e-11 37.6 In-house 246-309 (319) alignment 
Range on Protein: 1267-1329
Range on HMM: 246-309/319.0
HNAPTIVHCSAGVGRSGTFISIDRLLQSSSFG-DPIDVFGTVCEMRYERCQMVQNEQQYIFIHY
.. | .|||| ||||.|. |. |  ..|       .|.  .|  .| .|.. |.. .|| ||. 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1265-1334 2.7e-10 34.6 In-house 225-294 (297) alignment 
Range on Protein: 1265-1334
Range on HMM: 225-294/297.0
SPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 | ||...|||||||||||  .  | .|.    .   ||   .  .| .| ..||  .|. ...  .|. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1109-1219 8.5e-10 33.0 In-house 6-103 (130) alignment 
Range on Protein: 1109-1219
Range on HMM: 6-103/130.0
DHSRVKlsnpnnieGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKcVEKGrdkcHQYWPDHENVPVLYGDIEVTIVAEKEF
. ||..        | .||||..|      .|.. .| ||  |  .||.|  |.    .. |   ||.      .|||| | .     || ||.   .||
evsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdrdef

DEFVIRDIRLE
..     .. |
knikasnleie
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1267-1333 2.1e-08 27.9 In-house 264-342 (349) alignment 
Range on Protein: 1267-1333
Range on HMM: 264-342/349.0
HNAPTIVHCSAGVGRSGTFISIDRLLQ--------------SSSFGDPIdvFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
. .. .|||||| ||.|... .| ||.               .   |.|  . .| |.|  | .|||| .|.|.|. ..|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli..siivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1098-1181 3.6e-08 27.2 In-house 36-118 (332) alignment 
Range on Protein: 1098-1181
Range on HMM: 36-118/332.0
PKNRFTNIPSYDHSRVKLSNPNNieGGDYINANYVPGFSSRREFIAAQGPLPT-TRDHFWQMTWEQQCPAIIALTKCVEKGRDKC
  ||   .  .|||||.|.  .     |. ||..| |.| .  .| || |.   |   ||.|  |..   |. .    || . |.
dmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
0038934 (Phosphotyrosine protein) phosphatases II 1228-1287 1.9e-07 26.4 In-house 76-134 (194) alignment 
Range on Protein: 1228-1287
Range on HMM: 76-134/194.0
TRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNaPTIVHCSAGVGRSGTFIS
..   ... . .||.|..   . . .| ..  ..|  .|..    ||| ||.||.||.. 
ekagieylklpfpddgtvPsleillrfldlvdeflnedpgg.vvaVHCkaGlgRtGtlva
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1077-1249 8.4e-07 22.0 In-house 9-158 (169) alignment 
Range on Protein: 1077-1249
Range on HMM: 9-158/169.0
DMMRNVGVGQSvaASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINAnyvpgfssrrefiaaqgplpttrdhfwQMTWEQQCPAIIALTKCvek
..|. .   .    .|| .|  ||| .   .  | ||||    .  | |||||                           .| || .   |. |  .   
efmktieynnf..maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt...

grDKCHQYWPDHENVP----VLYGDIEV--TIVAEKEFD-----EFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPN
  |   ..||..|.      |. |.       |    ..        . .. | .   |  ||. .. .|| .||. | |  | 
..ddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1077-1248 1.3e-06 21.4 In-house 10-158 (169) alignment 
Range on Protein: 1077-1248
Range on HMM: 10-158/169.0
DMMRNVGVGQSvaASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINAnyvpgfssrrefiaaqgplpttrdhfwQMTWEQQCPAIIALTKCvek
..|. .   .    .|| .|  ||| .   .  | ||||    .  | |||||                           .| || .   |. |  .   
efmktieynnf..maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt...

grDKCHQYWPDHENVPVlygdIEVTIVAEKEFDEFVIRDIRLEK--SG-------------PDGRVTRFVRHWHYMAWPDFGAPSHP
  |   ..||..|.  .        |. |   | . .|  ....  ||              |  ||  .. .|| .||. | |  |
..ddknnfwpekedyql....hpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqsp
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1092-1170 4.2e-06 20.5 In-house 33-116 (347) alignment 
Range on Protein: 1092-1170
Range on HMM: 33-116/347.0
ELPINRPKNRFTNIPSYDHSRVKLSnPNNIEGG------DYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
|   .  |||  .    | .|| || |.. . .       |||| ..    ...|.| .| ||| |   ||.|    .   ....
ewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
PTEN_1 1234-1286 5.7e-06 21.3 In-house 97-148 (196) alignment 
Range on Protein: 1234-1286
Range on HMM: 97-148/196.0
WHYMAWPDFGAPShPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFI
.. . ..|.||||  . .. . . | . |   |..   .||| ||.||||| .
ylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv