Gene MTMR10 in Caenorhabditis elegans

Synonym: CELE_Y48G1C.10, Y48G1C.10

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP134_AA protein Get Run
CeleP134_AA_192-584 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR10_pd Subfamily MTMR10 193-583 8.9e-166 543.3 In-house 1-380 (380) alignment 
Range on Protein: 193-583
Range on HMM: 1-380/380.0
FNSYEAWRSELQRCQQKTDSTSVWKIVALNKEGFNYAAQGYPVYVVVSNFLDRVDIERQLQHYKQGRFPIWVWSRANGHSALFVSADHENNIAMPAILAK
..|.|||||||.|...|...|....||.|.|.....|||..|.|.||.|.|...|.||...|||..|||.||||.|.|...|..||..|...|......|
yaskeawrselerleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeek

MQESITRCHPNNekphVIKL-----DVDFVSNVGKAFDNLLSLCAIDSYEQYVTLQNGWNTKLSRTGWLHLVKLCLQTTYQTIQWIVDRDRSVILQEDEG
|.|....|||.|    ..||     .......|.||...| .||.||..|..|||...|...|..|.||..|.|||.|........|...|||||||.||
mlelvrkchpan....dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqeseg

SDMSIIVASLTQMCCDPFYRTTTGLQQLIEKMWIALGHPFGERlLGRTDDDPSRRGkpqnkmrtdvmPTWLLFLDCVSQLHRIYTFEFTFSPHVLIALWD
.|.|..||||.|...||.|||..|.|.||.|.|.|.|||| .| ||..........           |..|||||||.||......||.|....||||||
rDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldr.lghikpsekses...........pvfllFldcvdqlleqfpseFeFtetfLialwd

LSLTGMVPSMACNNLEEQLLAKVGGGPFPLDRYFEKSYSKLFGNIWHDAVLFMESIKKNQPVCAHSKFLQCEFIRPPTSFCDIQLWSECYLRWIPP
.| .|.......|. |..| |.|...|........|....|.........|..|.||......|....|..|.|||.....|||||.||||||.|.
sshsgifltflfnseeqrlkavvsssplliakselkendllkdeldyrqglyaeiiksirrlaaaksylrseiirPllqipdiqlWdeCYlRWvPs
0040695 (Phosphotyrosine protein) phosphatases II 190-582 6e-77 252.9 In-house 4-387 (388) alignment 
Range on Protein: 190-582
Range on HMM: 4-387/388.0
KTAFNSYEAWRSELQRCQQKTDstsVWKIVALNKEGfnYAAQGYPVYVVVSNFLDRVDIERQLQHYKQGRFPIWVWSRANGHSALFVSADHENNIAMPAI
.. ..|. ..  ||.|.. ..|   .|.|. .|...  . .. || ..|| ....  ...| ......||.|.......|....|. |... .....  .
leegwslydilrelkrlglgld...lwrisivNeny..elcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrs

LA--KMQESITRCHPNNEKPHVIKL------------------------------DVDFVSNVGKAFDNLLSLCaiD-SYEQYvtlqnGWNTKLSRTGWL
|.  |. |.|....||..| ....|                              ... ...| ... .||..|  . . . .      ....|. .|||
ledeklleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac..lnvpdsl.....nllslleesgwl

HLVKLCLQTTYQTIQWIVDRDRSVILQEDEGSDMSIIVASLTQMCCDPFYRTTTGLQQLIEKMWIALGHPFGERLLGRTDDDpsrrgkpqnkMRTDVMPT
.|.||.|.... ..... . . ||.... .| |.  .. ||.|...||.|||  |.| |||| |...||.| .||    ...           .....|.
dliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghlesei..........dskefsPv

WLLFLDCVSQLHRIYTFEFTFSPHVLIALWDLSLTGMVPSMACNNLEEQLLAKVGGGPFPLDRYFEKSYSKlFGNIWHDAVLfmesikknqpvcahskfl
.||||||| ||.| . ..| |....|. |.| .....  .. .|.  |.| ..|    ..| .|.    |. | |...|                     
FllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkse.flnplYdpss..................

qCEFIRPPTSFCDIQLWSECYLRWIP
 .|...| .|..|..||.|.||||.|
.levllpslsvldlllWleyylrwlp
Myotub-related Myotubularin-like phosphatase domain 292-501 2.6e-41 134.5 Pfam-A 150-346 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 292-501 2.6e-41 134.5 In-house 150-346 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 308-581 1.4e-33 108.7 In-house 149-387 (389) alignment 
Range on Protein: 308-581
Range on HMM: 149-387/389.0
HVIKLDVDFVSNVGKAFDNLLSLCAIDsyeqyvTLQNGWNTKLSRTGWLHLVKLCLQTTYQTIQWIVDRDRSVILQEDEGSDMSIIVASLTQMCCDPFYR
..| ||.. .  | .....|  |.  .      . .. | ..|  | ||. .|| |..... .. .     ||..  ..| |    . ||... .|..||
elifldihnihvvReslkklkelvlpn......vddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyR

TTTGLQQLIEKMWIALGHPFGERLlGRtdddpsrrgKPQNKMRTDVMPTWLLFLDCVSQLHRIYTFEFTFSPHVLIALWDLSLTGMVPSMACNNLEEQLL
| .|.. |||| |.. ||.| ||| |.           .|.  ..  | .| |.||| ||.| . . | |  . || | | . ...  .. .|. .|.  
tieGfevliekeWlsfGHkfkeRl.gh.........gdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervk

AKVGGGPFPLDRYFEKSYSKLFGNIWHDAVLfmesikknqpvcahskflqCEFIRPPTSFCDIQLWSECYLRWI
.||     .|  |...| .. . ..... .                     . . | .|.. ..||.| |||| 
ekvkektvslwsyvnsskeeftnplyaeele...................kkvlypkaslrrlelWkeyylrwn
subfamily_MTMR9_pd Subfamily MTMR9 338-512 3.7e-33 107.2 In-house 178-343 (393) alignment 
Range on Protein: 338-512
Range on HMM: 178-343/393.0
QYVTLQNGWNTKLSRTGWLHLVKLCLQTTYQTIQWIVDRDRSVILQEDEGSDMSIIVASLTQMCCDPFYRTTTGLQQLIEKMWIALGHPFGERLLGRTDD
.  . .. .  .| ..|||. |.  |... .  | . . . .|.... || | ...|.||.|.  || .||  |...|||. ||  |||| .|    .  
daglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaak

DpsRRGKPQNkmrtdvmPTWLLFLDCVSQLHRIYTFEFTFSPHVLIALWDLSLTGMVPSMACNNLEEQLLAKVGG
.  .. | .        |..||||||| |. . .  .| |. ..||.|.  | .    .. |.| .|.  .|.  
e..tkkklsg.......pvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkk
subfamily_MTMR5_pd Subfamily MTMR5 304-484 1.2e-29 95.5 In-house 225-393 (483) alignment 
Range on Protein: 304-484
Range on HMM: 225-393/483.0
NEKPHVIKLDVDFVSNVGKAFDNLLSLCAIDSYEQYVTLQNgWNTKLSRTGWLHLVKLCLQTTYQTIQWIVDRDRSVILQEDEGSDMSIIVASLTQMCCD
. |  .| ...  ...| ..|  ||  |  .   .  . |  .  ..    ||. ..  || .   .. .  .. ||..  ..|.|.  .|.||.|.. |
dskaefipvelveirqvkasfkkllraClpstaveeaesqs.FlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllld

PFYRTTTGLQQLIEKMWIALGHPFGERllgrTDDDPSRRGKpqnkmrtDVMPTWLLFLDCVSQLHRIYTFEFTFSPHVLIA
|.|||  | . |.|| |.|.|| | .|    .   .|  .         . |..| ||||| |..| .  .| |. . |  
pyYRtleGFkvLveKEWLafGHrFtkr....snqtlsaqss.......gfaPvFlqFLDcvhqvsrqfPlafefndfylkf
subfamily_MTMR3_pd Subfamily MTMR3 316-509 1e-26 86.7 In-house 214-391 (442) alignment 
Range on Protein: 316-509
Range on HMM: 214-391/442.0
FVSNVGKAFDNLLSLCAiDSYEQyvtlqNGWNTKLSRTGWLHLVKLCLQTTYQTIQWIVDRDRSVILQEDEGSDMSIIVASLTQMCCDPFYRTTTGLQQL
 .  | |.|..| .|.. .|...     . | ..|  | ||. .   |... . .. .    |.|..   .| |    . .|.... ||.|||  |.. |
nihavrksfnslralls.qspde.....snwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvl

IEKMWIALGHPFGERlLGRTDDdpsrrgkpqNKMRTDVMPTWLLFLDCVSQLHRIYTFEFTFSPHVLIALWDLSLTGMVPSMACNNLEEQLLAK
.|. |...|| | .|  |  ..          .   .  | .| .||.| ||.| .   | |.   |. |   .....  .. .|. .|.   |
vereWldfGhkfadr.cghgen.........vddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeek
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 314-580 1.1e-26 86.0 In-house 161-402 (404) alignment 
Range on Protein: 314-580
Range on HMM: 161-402/404.0
VDFVSNVGKAFDNLLSLCAIDsyEQYVTLQNGWNTKLSRTGWLHLVKLCLQTTYQTIQWIVDRDRSVILQEDEGSDMSIIVASLTQMCCDPFYRTTTGLQ
.  ..|. .  ..| .|  .   .. .. ...| ..|  ..||  .|| |... . .. | ..  ||...  .| |    ..||.|.. ||.||| .| .
flnienihelreslkklkkav..nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFi

QLIEKMWIALGHPFGERLLGrtdddpsrrgkPQNKMRTDVMPTWLLFLDCVSQLHRIYTFEFTFSPHVLIALWDLSLTGMVPSMACNNLEEQLLAKVGGG
 |||| |. .|| | .|               ..|   .  | .| |.||| || . .  .| |. ..|| . | .  .      ... .|   ...   
vliekewlsfGhkfaqRigq...........ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlake

PFPLDRYFEKSYSKLFGNIWHD-AVLFMESIKKNQPVCAHskflqcefirpptSFCDIQLWSECYLRW
   |  . |.  |... ...        |.|....   ..             .   |.|||| ||||
tvslWalleankseylnplyilekkeqkenitssessssa.............dikliklWseyylrw
3-PAP Myotubularin-associated protein 542-626 1e-22 70.9 Pfam-A 49-142 (142) alignment 
Range on Protein: 542-626
Range on HMM: 49-142/142.0
SIKKNQPVCAHSKFLQC---------EFIRPPTSFCDIQLWSECYLRWIPPANGKNSGKLGEELSLDEKMIEMAKKWNSSEWKMHLDLPEEYSS
|.....|..|.... ..         ....| ....|..|||.||||||| |. |..|. ...|.| |.. |.|| ..  |.....||||....
svsspspataseqlsktassvPadlhqlLlpqqlgldlslWsqcylRwiPeaeikgggqvqvdlklselleeiaklqrlleqrdmsdlpeanle
subfamily_MTMR6_pd Subfamily MTMR6 334-542 1.2e-22 72.8 In-house 180-365 (397) alignment 
Range on Protein: 334-542
Range on HMM: 180-365/397.0
DSYEQYVTLQNGWNTKLSRTGWLHLVKLCLQTTYQTIQWIVDRDRSVILQEDEGSDMSIIVASLTQMCCDPFYRTTTGLQQLIEKMWIALGHPFGERLlG
.  |.  . .. . . |  .|||. .|  |...    . . ... ||..   .| | .  |.||...  ||.|||  |.. |||| |...|| | ||  |
evvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfserc.G

RTdddpsrrgkpqNKMRTDVMPTWLLFLDCVSQLHRIYTFEFTFSPHVLIALWDLSLTGMVPSMACNNLEEQLLAKVGggpfpldryfEKSYSkLFGNIW
             ..   .| | .. ||.|| || . ..  | |. . |..| |   .    .. .|. ...  .|.           |...| |.. ..
ll...........dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklk..........ertks.lwayll

HDAVLFMES
..   ... 
erkddylnp
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 346-487 3.3e-18 57.7 In-house 203-331 (405) alignment 
Range on Protein: 346-487
Range on HMM: 203-331/405.0
WNTKLSRTGWLHLVKLCLQTTYQTIQWIVdRDRSVILQEDEGSDMSIIVASLTQMCCDPFYRTTTGLQQLIEKMWIALGHPFGERLlGRTdddpsrrgkP
.   .  |||.  .|  |...  . . |. .  |....  .| | .  ..||||.  ||.||| .|.| |||| |...|| |  || |           |
fwgyieetgwishiksileaatfsaelil.kgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrl.ghl.........p

QNKmrTDVMPTWLLFLDCVSQLHRIYTFEFTFSPHVLIALWD
 |.   .  | .  ||||. ||   . . | |.| .|. . |
gne..eerspifqqfldccfqllsqfpllfeftpslllfisd
subfamily_pats1_pd Subfamily pats1 343-442 1.9e-16 51.6 In-house 367-469 (691) alignment 
Range on Protein: 343-442
Range on HMM: 367-469/691.0
QNGWNtKLSRTGWLHLVKLCLQTTYQtIQWIVDRDRSVILQEDEG-SDMSII---VASLTQMCCDPFYRTTTGLQQLIEKMWIALGHPFGERLLGRTDDD
.. |. .. .  |.  ||| |... . .   .|. .||.|..     .. .    ..||.|.  ||||||  |.. |||| |.  |.|| ..   ...||
ddewk.eieeskwvdsvkllleaavk.vsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskinyhkesdd

-PSRR
     
lnnnn
Myotub-related Myotubularin-like phosphatase domain 194-274 9.7e-08 24.1 Pfam-A 21-97 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 194-274 9.7e-08 24.1 In-house 21-97 (353) alignment
subfamily_MTMR5_pd Subfamily MTMR5 211-284 3.6e-07 21.4 In-house 26-97 (483) alignment 
Range on Protein: 211-284
Range on HMM: 26-97/483.0
DSTSVWKIVALNKEgFNyAAQGYPVYVVVSNFLDRVDIERQLQHYKQGRFPIWVWSRANGHSALFVSADHENNI
 ..  ..| . ||. ..  .. ||  .|| . ..   |.|  ....|.|.|. .|  .   . |  |.  |.. 
skrgkfrisevNkk.yt.vcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskg
subfamily_MTMR1_pd Subfamily MTMR1 196-277 6.2e-06 17.7 In-house 10-86 (389) alignment 
Range on Protein: 196-277
Range on HMM: 10-86/389.0
YEAwRSELQRCQQKTDStsVWKIVALNKEgFnYAAQGYPVYVVVSNFLDRVDIERQLQHYKQGRFPIWVWSRANGHSALFVS
|..  .||.|    ..   .|.|. |||. .   .. ||  .|| .  .  |...  . ...||.|. .|   . ....  .
ydp.eaelerlgllnek..lWritklnkk.y.elcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilra