Gene PTPDC1 in Caenorhabditis elegans

Synonym: CELE_T12B3.1, T12B3.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP163_AA protein Get Run
CeleP163_AA_68-232 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPDC1_pd Subfamily PTPDC1 62-233 3.6e-85 279.0 In-house 7-177 (182) alignment 
Range on Protein: 62-233
Range on HMM: 7-177/182.0
EiQAIDGLYSTWITSDILAMARLQVEHFDSLGIVEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIV
| |||.||||||.|.||||.||...|..|......|||..||..||||||.|||..||.|. .||||||.|.||..|||.|||...|..... .|.||||
e.qaikGlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdiv

KVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRN
|||.|||..||.|||||||.||||..||....||  .....|...|||.|.|..|..|||....||.|.. .
kvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflip
0046846 (Phosphotyrosine protein) phosphatases II 66-232 8.2e-38 125.2 In-house 7-173 (176) alignment 
Range on Protein: 66-232
Range on HMM: 7-173/176.0
IDGLYSTWITSDILAMARLQVEHFD----SLGIVEKFKTNGIQSVINLQESGEHSFCGsgnltsgFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIV
...|....|. ......|  . . .        .| .| .||. |.||.|  |.....       . .... |...|| ....| ||..... . ||...
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk.......cpnywpeleklgiqylhlpwpDhgvpdlelllell

KVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMYA-LGMSPSQAVDTVRSRRA-KAVQSKEQVKTLHEFRLLIR
. .. ||..| ...|||.||.||||...||....   |.|. .|...||..|  .|||. ||.. |.|| ||..
efirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0038934 (Phosphotyrosine protein) phosphatases II 71-233 2.5e-34 114.0 In-house 13-178 (194) alignment 
Range on Protein: 71-233
Range on HMM: 13-178/194.0
STWITSDILAMARLQVEHFDSLgiVEKFKTNGIQSVINLQESGEHSFCGSGNLTS-GFSYDPENLMRNGIYHYNFPLPDFQAC-TPNRLLDIVKVVDF--
...|| ...|...   ...|.   .| .. ... ..... ..  .  .   .||  .. |||| ....||.....| ||. .. . . ||.....||.  
gdiitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl

-ALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRN
 . ..|..||||.||.||||...||...| ||||. .|....|..| .|... .... |...   .|.
nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
PTEN_1 93-231 2.6e-34 113.8 In-house 47-192 (196) alignment 
Range on Protein: 93-231
Range on HMM: 47-192/196.0
GIVEKFKTNGIQSVINLQESGEHSFCGSGNLT--SGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGM
|  ... .   . . ||.|.| .. .   .    ||.|||.|  ...|. ...|| .|..|.. ..|.||.|... .|.    .....|||.||.||.|.
glyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGt

VIAAWMMYALGMSPSQAVDTVRSRR-AKAVQSKEQVKTLHEFRLLI
|.||..||. .... .|.. ||..| . |..| .| . |..|. | 
vvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0043147 (Phosphotyrosine protein) phosphatases II 70-232 6.7e-34 112.5 In-house 14-161 (172) alignment 
Range on Protein: 70-232
Range on HMM: 14-161/172.0
YSTWITSDILAMARLQVEHFDSLgiVEKFKTNGIQSVINLQESgehsfcgsgnltsgfSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDF---
. ..|. ...|.  .  .....   .. .|..||. ..|| |                 ||||.|.|.|| .. .| ||. ..... ||.... .|    
dlyyipdrfiatqgplrntladf..wrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidella

ALSHGKIAVHCHAGHGRTGMVIAAWMMYaLGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIR
  ..|...|||.|| ||||...||..|. ||.|. .||..||..| .|||...| . |..|  |..
lspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0044763 (Phosphotyrosine protein) phosphatases II 57-235 2.1e-33 110.8 In-house 9-174 (178) alignment 
Range on Protein: 57-235
Range on HMM: 9-174/178.0
VTGQTEIQAIDGLYSTWITSDILAMARLQvehfdsLGIVEKFKTNGIQSVINLQESGEHSFCGsgnltsgfsYDPENLMRNGIYHYNFPLPDFQACT-PN
..    ....|... ..|. ......  .         .| .| .||....|| |  |. |..         .||. ....|| ....|.||. ... . 
lsnleglersdyinaseilpglylgslpp......addlellkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdlle

RLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAkAVQSKEQVKTLHEFRLLIRNNG
 .|..|. .. |   ..|...|||.|| ||.|...||..|. ||.|. .|.. ||.||  .|.. .|.. |.|| | .....
hflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
0036282 (Phosphotyrosine protein) phosphatases II 72-232 4.3e-33 109.8 In-house 13-170 (174) alignment 
Range on Protein: 72-232
Range on HMM: 13-170/174.0
TWITSDILAMARLQVehfdslgIVEKFKTNGIQSVINLQESGEHSFCGSGNLTSGfsyDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALSH-
..||. ..|..            .| .| .||..|..| |. |   ..  |...    ..| | |.|| .. .| ||... . . ||..|| |. |||. 
syitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpe...lredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

--GKIAVHCHAGHGRTGMVIAAWMMYALGM-SPSQAVDTVRSRR---AKAVQSKEQVKTLHEFRLLIR
  |...|||.|| ||||...||..|. ... |. .|.|.||..|    ..||. .| . |..|. |..
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
0041856 (Phosphotyrosine protein) phosphatases II 68-236 2e-32 107.6 In-house 16-175 (182) alignment 
Range on Protein: 68-236
Range on HMM: 16-175/182.0
GLYSTWITSDILAMARLQVEHFDS--------LGIVEKFKTNGIQSVINLQesgehsfcgsgnltsGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLD
......|.  ...... . .               .. .| .||....||                .. |.||.|.|.|| ....| ||. ..... |||
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...............eelywpellerlgiqylylpwpDhgvpdldelld

IVKVVDFalSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGG
... |    ..|...|||.|| ||||...||..|. ||.|. .||..||||| ..|.. .|   |. . |... .. 
fieevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
0048076 (Phosphotyrosine protein) phosphatases II 95-230 8e-30 98.8 In-house 22-141 (145) alignment 
Range on Protein: 95-230
Range on HMM: 22-141/145.0
VEKFKTNGIQSVINLqesgehsfcgsgnltsgfSYDPENLMRNGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWM
.| .| .||  |.||                  ....|.| |.|| ....|.||... .  . ||.... .. ||..| ...|||.|| ||||...||..
lellkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLL
|. ||.|. .|.. |||.| .||.. .|.. |.|| | 
mlllgvsleealelvrsqrpgavpnpgqlrflyefele
0045098 (Phosphotyrosine protein) phosphatases II 96-234 6.3e-29 96.6 In-house 82-274 (278) alignment 
Range on Protein: 96-234
Range on HMM: 82-274/278.0
EKFKTNGIQSVINLQESGEHSFCGSGNLTSG-------------------------------FSYDPENLMRNGIYHYNF-PLPDFQACTPN---RLLDI
. .. .||.....| |  | . .                                       ... .|.|. .|..|... | ||. . . .    .|..
rmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflel

VKVVDFAL---------------SHGKIAVHCHAGHGRTGMVIAAWMMYAL---GMSPSQAVDTVRSRRAK-AVQSKEQVKTLHEFRLLIRNN
.. .. ||               |.|...|||.|| ||||...||..|. |   |... .||...||.|   |||..|| . |.|| |.....
lefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0048179 (Phosphotyrosine protein) phosphatases II 95-227 7.9e-29 95.6 In-house 22-140 (144) alignment 
Range on Protein: 95-227
Range on HMM: 22-140/144.0
VEKFKTNGIQSVINLQESGEHSFCGSGnltsgfsydpenlmrnGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALS-HGKIAVHCHAGHGRTGMVIAAWM
.| .| .||  ||||.|. |. |..                  || ....|.||... .  . ||.... .. ||. .|...|||.|| ||||...||..
lellkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
|. ||.|. .|.. |||||  ||.. .|.. |.|.
mkklglsleealalvrsrrpgavpnpgqlrfLley
0037934 (Phosphotyrosine protein) phosphatases II 96-230 5.2e-28 93.7 In-house 66-240 (243) alignment 
Range on Protein: 96-230
Range on HMM: 66-240/243.0
EKFKTNGIQSVINLQESGEHSFCGSGNLTS---------------------------GFSYDPENLMRNGIYHYNFPLPDFQACT-PNRLLDIVKVVD--
. .. .||.....| |  |.. ..   . .                              .|...| |..| .. .| ||... . |. |||... |   
rmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevref

--------FALSHGKIAVHCHAGHGRTGMVIAAWMMYAL-GMSPSQAVDTVRSRRAK-AVQSKEQVKTLHEFRLL
         . |.|...|||.|| ||||..|||..|. | |... .||...|..|   |||. .| . |.|. | 
ieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0049260 (Phosphotyrosine protein) phosphatases II 96-228 9.6e-28 92.2 In-house 27-146 (152) alignment 
Range on Protein: 96-228
Range on HMM: 27-146/152.0
EKFKTNGIQSVINLQESGEHSFCGSGNLTsgfsydpenlmrngiYHYNFPLPDFQACTPNRLLDIVKVVD---FALSHGKIAVHCHAGHGRTGMVIAAWM
. .|..||. ...| |  |  ...  ..                 ....| ||. ...   ||...  ..      ..|...|||.|| ||||...||..
rmlkelgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

MYaLGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
|. ||.|. .||. ||..| .||....| . |.|| 
ml.lgvsleeavalvrekRpgavpnpgqlrflyefe
0042113 (Phosphotyrosine protein) phosphatases II 95-229 9.9e-28 92.6 In-house 65-240 (245) alignment 
Range on Protein: 95-229
Range on HMM: 65-240/245.0
VE----KFKTNGIQSVINLQESGEHSFCGSGNLTSG----------------------------FSYDPENLMRNGIYHYNFPLPDFQACT-PNRLLDIV
||     .. .||.....| |  |......    .                              ......  |..| .. .| ||..... .. |||..
vedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfl

KVVDFALS---HGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRL
. |. ||.   .|...|||.|| ||||..|||..|     . ||.|. .||. .||.| .|||. .| . |.|. |
efvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 98-231 2.1e-27 91.8 In-house 74-245 (249) alignment 
Range on Protein: 98-231
Range on HMM: 74-245/249.0
FKTNGIQSVINLQESGEHSFCGSG------------------------------NLTSGFSYDPENLMRNGIYHYNFPlpDFQAC-TPNRLLDIVKVVDF
.. .||.....| .  |. ...                                .|.  ..||.| .. ..|.....|  |.... ... |||... |. 
lwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrk

AL----SHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLI
||    ..|...|||.|| ||||..|||..|     . ||... .||...||.| .|||. || . |.|. | .
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 95-234 3.8e-27 90.9 In-house 118-291 (297) alignment 
Range on Protein: 95-234
Range on HMM: 118-291/297.0
VEKFKTNGIQSVINLQESGEHSF-CGSGNLTSGFSYD------PENLMRNGIYHYNFPL-----------------PDFQAC-TPNRLLDIVKVVDFAL-
 . .. .|......| .  |..  | .   ..|  |.       .  ...|........                 ||.... ... ||.... |. || 
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---SHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNN
   ..|...|||.|| ||||..|||..|     .  |... .||...|..| .|||. .| . |... |  ...
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040438 (Phosphotyrosine protein) phosphatases II 98-244 1.2e-26 89.1 In-house 106-288 (317) alignment 
Range on Protein: 98-244
Range on HMM: 106-288/317.0
FKTNGIQSVINLQESGEhsfcgsgnltsgF------SY--------------------DpenlmRNGIYHYNFPL-------------------PDFQAC
.. .|......| |. |            .       |                           .|| ......                   ||. . 
vweqgvtvivmLtelee............lgrekcaqYwplgetltygdftvtllseee.....lagitlrtlevedlgdsesrtvthfhytgWpdhgvp

-TPNRLLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGGMIIPKNKM
 .|. |||... |. ||.  .|...|||.|| ||||..|||..|     .  |... .||...|..|..|||. || . |... | . ..... .| .. 
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
0049772 (Phosphotyrosine protein) phosphatases II 102-228 3.9e-26 87.9 In-house 155-270 (314) alignment 
Range on Protein: 102-228
Range on HMM: 155-270/314.0
GiqsvinlqesGEHSFCGSGNLTsGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALSHGKIAVHCHAGHGRTG-MVIAAWMMYALGMSP
|          .| ...   .|  .  |||| . |.|| ....|.||..| ... ......... |  .|...|||.|| |||| .|.||..|..||.|.
g..........neptaadlellk.eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

SQAVDTVRSRRAkAVQSKEQVKTLHEFR
 .|.. ||..|  .  .. ....| .. 
eealedvrlkRp.inpnpgfieqleqye
0043336 (Phosphotyrosine protein) phosphatases II 98-228 1.2e-25 86.0 In-house 108-273 (278) alignment 
Range on Protein: 98-228
Range on HMM: 108-273/278.0
FKTNGIQSVINLQESGEHSFCG-----------------------------SGNLTSGFSYDPENLMRNGIYHYNFPlpDFQAC-TPNRLLDIVKVVDFA
.. .|......| |  |.. ..                               .|.    .|.| .. ........|  |.... ... |||..|.|. |
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrea

L--SHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
|  |.|...|||.|| ||||..||....     . .|... .||...|..|..|||. .| . |.|. 
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 98-230 2.2e-25 85.5 In-house 127-302 (307) alignment 
Range on Protein: 98-230
Range on HMM: 127-302/307.0
FKTNGIQSVINLQESGEHSFC---------------------------GSGNLTSGFSYDPENLMRNGIYHYNFPL---PDFQAC-TPNRLLDIVKVVDF
.. .|.. ...| |. |. .                             .|     .   . .   ...... |.    ||.... ... |||... |. 
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

AL----SHGKIAVHCHAGHGRTGMVIAAWMMYALG--------MSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLL
||    ..|...|||.|| ||||..|||..|. ..        ... .||...|..| .|||. || . |.|. | 
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 72-225 5.6e-24 79.9 In-house 9-146 (151) alignment 
Range on Protein: 72-225
Range on HMM: 9-146/151.0
TWITSDILAMARLqVEhfdslGIVEKFKTNGIQSVINLQESGEHSfcgsgnltsgfsYDPENLMRNGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALS-
...|. ..... .  .       .| .|..||....|| .  |.             |.|| | ..|| ....|..|... .    .  ........|. 
syvtgglyrsggp.la.....dflellkelgiktivnlrseeerg............ycpeylpelgievlhipildwpdpglplsfdavleflellldk

-HGKIAVHCHAGHGRTGMVIAAWMMYaLGMSPSQAVDTVRSRRAKAVQSKEQVKTLH
 .|...|||.|| ||||...|...|. ||.|. .|.. .|..|  .||...|   ..
kngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfql
0051429 (Phosphotyrosine protein) phosphatases II 97-229 7.1e-24 80.3 In-house 40-222 (272) alignment 
Range on Protein: 97-229
Range on HMM: 40-222/272.0
KFKTNGIQSVINLQESGEHSFCGSGNLTsgfsydpenlmrNGIYHYNFPLPDFQACTPN-----------------------------------------
..|..|| ....| .  |. ...   .              || ....|..|. | |..                                         
rlkelgiktivdLrseeErgrlkcdryw............pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

----------RLldIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYaLGMS--------------PSQAVDTVRSRRAKAVQSKEQVKTLHEFRL
              ....... |..|.. |||.|| .|||.|.|..... ||.|              . .||. .|..|..|||. ||.. |.|. |
tdwpdhgvpqea..llellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall
0036941 (Phosphotyrosine protein) phosphatases II 139-244 1.5e-22 75.7 In-house 170-289 (297) alignment 
Range on Protein: 139-244
Range on HMM: 170-289/297.0
IYHYNFP-LPDFQACT-PNRLLDIVKVVDFAL----SHGKIAVHCHAGHGRTGMVIAAWMM--------YALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
..|. ..  ||. . . |. |||... |. .|    |.|.. |||.|| ||.|..|||..|        .  |... .|| ..|..|. |||. || . |
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

HEFRLLIRNNGGMIIPKNKM
.|. |   ... ...| .|.
yeallellkkkltkepllkl
0047943 (Phosphotyrosine protein) phosphatases II 139-227 1.3e-21 72.8 In-house 168-267 (273) alignment 
Range on Protein: 139-227
Range on HMM: 168-267/273.0
IYHYNFP-LPDFQAC-TPNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
..|. ..  ||.... ... ||.....|. ||.    .|...|||.|| ||||..||....     .  |... .||  .||.|  .||. || . |.|.
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea
0046845 (Phosphotyrosine protein) phosphatases II 139-230 2.5e-21 71.8 In-house 167-272 (284) alignment 
Range on Protein: 139-230
Range on HMM: 167-272/284.0
IYHYNF-PLPDFQACT-PNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGMVIAAWMMYAL--------GMSPSQAVDTVRSRRAKAVQSKEQVKTL
..|. . . ||..... |. ||.... |. .|.    .|.|.|||.|| ||||..||..... .        |... .||  .|..|  .||. || . .
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

HEFRLL
.|. | 
yealle
0050432 (Phosphotyrosine protein) phosphatases II 139-229 1.3e-20 69.5 In-house 199-296 (308) alignment 
Range on Protein: 139-229
Range on HMM: 199-296/308.0
IYHYNFPL-PDFQACT-PNRLLDIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRL
..|. ..  ||..... |. |||... |.  |..|.|.|||.||.|||| .||....     .  |... .|| ..|..|. .||..|| . |..  |
vthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall
0051299 (Phosphotyrosine protein) phosphatases II 133-226 3.3e-19 64.9 In-house 179-280 (288) alignment 
Range on Protein: 133-226
Range on HMM: 179-280/288.0
NLMRNGIYHYNFPLPDFQACT-PNRLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
.  |. . .. .  ||... . |. |||... |. |   ..| ..|||.|| ||||..||....     .  |... .|| ..|..|  .||. || . .
gesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv

HE
.|
ye
DSPc Dual specificity phosphatase, catalytic domain 96-228 9.8e-17 56.1 Pfam-A 12-131 (133) alignment 
Range on Protein: 96-228
Range on HMM: 12-131/133.0
EKFKTNGIQSVINLQESGEHSfcgsgnltsgfsydpENLMRNGIYHYNFPLPD-FQACTPNRLLDIVKVVDFAL-SHGKIAVHCHAGHGRTGMVIAAWMM
.. . .||. |||.... ...                    . | . . |. |  .. . . | ..|.... |  ...|..||| ||  |....|.|..|
alleklgitlvinvtkevpnn...............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm

YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.  ..| ..|.. |..|| | ... .....| |..
ktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 96-228 9.8e-17 56.1 In-house 12-131 (133) alignment 
Range on Protein: 96-228
Range on HMM: 12-131/133.0
EKFKTNGIQSVINLQESGEHSfcgsgnltsgfsydpENLMRNGIYHYNFPLPD-FQACTPNRLLDIVKVVDFAL-SHGKIAVHCHAGHGRTGMVIAAWMM
.. . .||. |||.... ...                    . | . . |. |  .. . . | ..|.... |  ...|..||| ||  |....|.|..|
alleklgitlvinvtkevpnn...............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm

YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.  ..| ..|.. |..|| | ... .....| |..
ktknlslneAyefvkerrskispnagflrqLleye
subfamily_PTPMT1_pd Subfamily PTPMT1 132-228 1.5e-16 55.3 In-house 67-165 (171) alignment 
Range on Protein: 132-228
Range on HMM: 67-165/171.0
ENLMRNGIYHYNFPLPDFQ-ACTPNRLLDIVKVVDFALSHGK-IAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
|.  ..|. ..... .||  | . ..|.. |....   |.|| . |||.||.||.. ..|...|.   .|| .|.......| .    |.|.|.|.|..
eewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye
PTPc_motif_SM00404 96-228 2.1e-16 55.1 In-house 21-138 (140) alignment 
Range on Protein: 96-228
Range on HMM: 21-138/140.0
EKFKTNGIQSVINLQESGEHSfcgsgnltsgfsydpenLMRNGIYHYNFPLPD-FQACTPNRLLDIVKVVDFAL-SHGKIAVHCHAGHGRTGMVIAAWMM
.. | .||. |||..|. . .                    .|. . . || |  .. . . |  ...... |  ..||. ||| ||  |....|.|..|
allkklgithvinvteevslt.................kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.  ..| ..|.. |..|| .  .. . |..|.|..
ryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_CDC14_pd Subfamily CDC14 94-220 2.9e-16 54.2 In-house 204-313 (328) alignment 
Range on Protein: 94-220
Range on HMM: 204-313/328.0
IVEKFKTNGIQSVINLQESgehsfcgsgnltsgfSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFAlsHGKIAVHCHAGHGRTGMVIAAWMM
..| |..|....|. | .                 || ..   .|. |..    |    . . .   ..... |  .|.|||||.|| |||| .||...|
lleyfrknnvttvvrLnkk...............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka..eGaiavhCkaGLGrtGtLiacylm

YALGMSPSQAVDTVRSRRAKAVQSKEQ
.  ... ..|.  .|  |   | .. |
khyrftaaeaiawlricrPGsvigpqq
subfamily_DSP23_pd Subfamily DSP23 140-231 6.7e-14 46.8 In-house 53-145 (148) alignment 
Range on Protein: 140-231
Range on HMM: 53-145/148.0
YHYNFPLPDFQACTPNRLLDIVKVVDFALSHGK-IAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLI
  ... ..|..  ..... ..|.||. | .... ..|||  |.|||| ..| ...   ... ..|.  || .|  .|.. || | ....  .|
tlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi
0048567 (Phosphotyrosine protein) phosphatases II 165-231 1.4e-13 45.5 In-house 64-138 (157) alignment 
Range on Protein: 165-231
Range on HMM: 64-138/157.0
D-----FALSHGKIAVHCHAGH---GRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLI
.     . | ...|||||.||    |||...|...... ||..|..|.. .|  | . |   ..   |. . |..
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltl
PTPc_DSPc_SM00012 146-226 4.3e-13 44.7 In-house 10-101 (105) alignment 
Range on Protein: 146-226
Range on HMM: 10-101/105.0
LPDFQAC-TPNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGMVIAAWMMYAL----G--MSPSQAVDTVRSRRAKAVQSKEQVKTLHE
 ||...  ... .|.... |.   .    .. . |||.|| ||||...|. ...         .. .| |  .|..|...||..||.  |..
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
subfamily_PTEN_pd Subfamily PTEN 72-227 9.2e-13 43.6 In-house 23-175 (184) alignment 
Range on Protein: 72-227
Range on HMM: 23-175/184.0
TWITSDILAMArlqvehFDSlGIVEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYDPENLmRNGIYHYnfPLPDFQACTPNRLLDIVKVVDFALSHG
..||. |.||.      . .   .|.   | .. |... |.  .      ||.|. .|| ... .. . .|  |. | .. . . | .||. ..  |.. 
syiteniiamg......yPa.eklealyRnsledvvkflekkhkdhykiynlrserkydskkf.dgrvavy..pfdDhnppplelleeivediekwleed

K---IAVHCHAGHGRTGMVIAAWMMYALGMSPS-QAVDT---VRSRRAKAVQSKEQVKTLHEF
|   ..|||.||.||||..|.|.....| .. . .|..    .|.. .|.|.   | . .. .
kknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy
subfamily_PRL_pd Subfamily PRL 128-228 6.2e-12 39.8 In-house 45-146 (151) alignment 
Range on Protein: 128-228
Range on HMM: 45-146/151.0
SYDPENLMRNGIYHYNFPLPDFQACTPN---RLLDIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMyALGMSPSQAVDTVRSRRAKAVQSKeQVKTL
.|| |.| ..||   .... | .. . .   . |...|      ..  .|||| || ||. ...|  ..   ||.. .||. .|..|  |. || |.| |
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali.eaGmkyedavefirekrrgainsk.qlkfl

HEFR
....
ekyk
Y_phosphatase Protein-tyrosine phosphatase 148-226 9.3e-12 40.2 Pfam-A 145-231 (235) alignment 
Range on Protein: 148-226
Range on HMM: 145-231/235.0
DFQAC-TPNRLLDIVKVVDFAL--SHGKIAVHCHAGHGRTGMVIAAWMMYALGMS-----PSQAVDTVRSRRAKAVQSKEQVKTLHE
| ..  .|. |||... |      ..|.. ||| || ||||...|....     .       |.| ..|..|...||| || . |..
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 148-226 9.3e-12 40.2 In-house 145-231 (235) alignment 
Range on Protein: 148-226
Range on HMM: 145-231/235.0
DFQAC-TPNRLLDIVKVVDFAL--SHGKIAVHCHAGHGRTGMVIAAWMMYALGMS-----PSQAVDTVRSRRAKAVQSKEQVKTLHE
| ..  .|. |||... |      ..|.. ||| || ||||...|....     .       |.| ..|..|...||| || . |..
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
subfamily_CDKN3_pd Subfamily CDKN3 98-229 1.5e-11 38.2 In-house 66-193 (202) alignment 
Range on Protein: 98-229
Range on HMM: 66-193/202.0
FKTNGIQSVINLQESGEHSFCGSGNLTSGFsydpenlMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMY-A
.|. |.. |. |   || |     .|   .        . |.  . .|..|  .  .   |.|.. .  .|  . |  |||. | ||. .|||  ..|  
lksqgvedvfvlctrgelskyrvrrlldly.......qqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllyld

LGMSPSQAVDTVRSRR-AKAVQSKEQVKTLHEFRL
  ..| .|.| .|  . ..|.|.  |   |.||| 
dtiepkdaidklrdlkgsraiqtvkqynylsefrd
DSPc_SM00195 147-227 9.1e-10 33.7 In-house 169-257 (263) alignment 
Range on Protein: 147-227
Range on HMM: 169-257/263.0
PDFQAC-TPNRLLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMMYALG-----MSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
|| ..  ... .|.....|.   |  .| | |||.|| ||||..... ...        .. .. |  .|. |...||..|| ....| 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea
PTPc_SM00194 147-227 9.1e-10 33.7 In-house 169-257 (263) alignment 
Range on Protein: 147-227
Range on HMM: 169-257/263.0
PDFQAC-TPNRLLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMMYALG-----MSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
|| ..  ... .|.....|.   |  .| | |||.|| ||||..... ...        .. .. |  .|. |...||..|| ....| 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea
subfamily_DSP3_pd Subfamily DSP3 143-212 2.8e-09 30.8 In-house 67-139 (162) alignment 
Range on Protein: 143-212
Range on HMM: 67-139/162.0
NFPLPDFQACTPNRL-LDIVKVVDFALSH--GKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRA
 ... |....  ..     .| .| |||.  ||. |||..|  |   .. |..|    |.  .|. |||..|.
GlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe
subfamily_DSP12_pd Subfamily DSP12 164-228 3.3e-09 31.3 In-house 75-140 (155) alignment 
Range on Protein: 164-228
Range on HMM: 75-140/155.0
VDFAL-SHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.. ||  .|.. |||.||  |   ...|..|.  ..| ..|...|.. . ..   .  .. |. |.
ieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfe
subfamily_PTPRK_pd Subfamily PTPRK 156-244 9.9e-09 29.4 In-house 194-289 (314) alignment 
Range on Protein: 156-244
Range on HMM: 194-289/314.0
RLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSP-----SQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGGMIIPKNKM
 ||..|. |.     ..|.| ||| || ||||. ||  ..  .          .|| |.|||.   |. .|| | ...  |     |   ||  ..
gllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsef
subfamily_CG42327_pd Subfamily CG42327 169-223 2e-08 28.3 In-house 246-306 (319) alignment 
Range on Protein: 169-223
Range on HMM: 246-306/319.0
SHGKIAVHCHAGHGRTGMVIAAWM-MYALGMS-----PSQAVDTVRSRRAKAVQSKEQVKT
|.| ..|||  | ||||.|||. . .  |  |       | |  ||  ||.||..||| . 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyef
subfamily_Tensin_pd Subfamily Tensin 126-210 3.4e-08 26.2 In-house 60-145 (189) alignment 
Range on Protein: 126-210
Range on HMM: 60-145/189.0
GFSYDPENLMRNgIyhYNFPLPDFQACTPNRLLDIVKVVDFALSHG---KIAVHCHAGHGRTGMVIAAWMMYA-LGMSPSQAVDTVRSR
  .|| ..| .. .   .|  || .| . ..|  |.| .|  |..     ..|||. |.||.|.|..|.| |. .  | ..|.|.   .
ekrydisklnkk.v..ldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamk
subfamily_DSP19_pd Subfamily DSP19 161-215 5e-08 27.4 In-house 79-134 (152) alignment 
Range on Protein: 161-215
Range on HMM: 79-134/152.0
VKVVDFALSH-GKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAV
.. .. |.|. | . |||.||  |.  |. |..|    .| ..|...||. |  . 
ldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcik
subfamily_DSP8_pd Subfamily DSP8 168-215 5e-08 26.7 In-house 91-138 (159) alignment 
Range on Protein: 168-215
Range on HMM: 91-138/159.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAV
 ..|.. ||..||. |   |. |..|  | ||  .|   |...|.   
sengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptis
subfamily_DSP1_pd Subfamily DSP1 168-213 5.7e-08 27.0 In-house 93-138 (163) alignment 
Range on Protein: 168-213
Range on HMM: 93-138/163.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAK
 ..||. .||.||  |   .. |..|    .| ..| | |..||. 
kknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi
subfamily_RNGTT_pd Subfamily RNGTT 168-224 6.2e-08 26.5 In-house 111-167 (189) alignment 
Range on Protein: 168-224
Range on HMM: 111-167/189.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
 ..  |.|||. |. ||| .|.....    .| ..||.. .. | . .  .. .| |
npeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 157-234 7.1e-08 26.8 In-house 197-281 (288) alignment 
Range on Protein: 157-234
Range on HMM: 197-281/288.0
LLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMMYALgMSPS------QAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNN
||.... |. | .   |.| ||| || ||||  ||. ..    .  .       .|  .| .||  || ..|   ..|  | . ..
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalida.veeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_Laforin_pd Subfamily Laforin 95-215 8.6e-08 25.3 In-house 30-155 (183) alignment 
Range on Protein: 95-215
Range on HMM: 30-155/183.0
VEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYdPEN---LMR-NGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALSHGK-IAVHCHAGHGRTGMVI
| ..|..|| .||.|| . .     ||      .  |.    | . .|. .  .|..|. . .  . | . | ..   | .|. . ||| || ||.  ..
vidlksegitavislqtesdivknssgiyrynenl.pitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaiv

AAWMMYALGMSPSQAVDTVRSRRAKAV
  ...| || | ..    . ..|  . 
cgflqyvlgwslakvqyfllakrpvvy
subfamily_DSP11_pd Subfamily DSP11 170-226 9.5e-08 26.1 In-house 116-172 (178) alignment 
Range on Protein: 170-226
Range on HMM: 116-172/178.0
HGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHE
   |.|||  |  ||| .|  ...   |..|..|...  . |  ... .. .| |..
dkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk
subfamily_PTPN12_pd Subfamily PTPN12 147-226 1.9e-07 25.3 In-house 181-271 (290) alignment 
Range on Protein: 147-226
Range on HMM: 181-271/290.0
PDFQAC-TPNRLLDIVKVVDFALSHG--KIAVHCHAGHGRTGMVIA---AWMMYALGMSPS-----QAVDTVRSRRAKAVQSKEQVKTLHE
|| .   ....||.... |    ..    ..||| || |||| .||   ....   .. |.     . | ..| .|| .||.||| . ...
PDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyk
subfamily_VSP_pd Subfamily VSP 72-217 2.7e-07 24.7 In-house 37-176 (212) alignment 
Range on Protein: 72-217
Range on HMM: 37-176/212.0
TWITSDILAMArlqvehFDSLGIvEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYDPENLmRNGIYhyNFPLPDFQACTPNRLLDIVKVVDFALSHG
|..|  |.||.      | | |  ...  | |. |  . .   .      || |  .||.. . .| .   .  . | .  . ..|| . | |   |.. 
tyvteriiams......fpssGk.qslyrnpisevarfldtkhrdhykvvnlcseraydekyf.nnrvk..riliddhnvpkleellvftkevkewlekd

---KIAVHCHAGHGRTGMVIAAWMMYALGMSP-SQAVDTVRSRRAKAVQS
    .|.||  |.|||| .. |.....  ..   ...|   .||..  ..
lknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdkteg
subfamily_PTPRA_pd Subfamily PTPRA 152-222 5.3e-07 23.8 In-house 208-285 (330) alignment 
Range on Protein: 152-222
Range on HMM: 208-285/330.0
CTPNRLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMMYA----LG-MSPSQAVDTVRSRRAKAVQSKEQVK
 .|  .|...| |      | | | ||| || ||||  |.   . .     . .   ..|  .| .|.. ||..|| .
fepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqye
subfamily_PTPRB_pd Subfamily PTPRB 139-227 6e-07 23.8 In-house 181-280 (293) alignment 
Range on Protein: 139-227
Range on HMM: 181-280/293.0
IYHYNFP-LPDFQAC-TPNRLLDIVKVVDFAL----SHGKIAVHCHAGHGRTGMVIAAWMMYAlGMSPSQA------VDTVRSRRAKAVQSKEQVKTLHE
. .|.|   ||.    ... |||.|. |. |.    |.. | ||| || ||||  ||  ..    .. ..       |  .|..|.  ||...|   .|.
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllq.aieeedyvdifgivaelReeRnllvqtekqYifihq

F
 
c
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 137-226 6.2e-07 23.8 In-house 161-262 (274) alignment 
Range on Protein: 137-226
Range on HMM: 161-262/274.0
NGIYHYNFP-LPDFQAC-TPNRLLDIVKVVDFALSH-----GKIAVHCHAGHGRTGMVIAAWMMYaLGMSPSQAVDT------VRSRRAKAVQSKEQVKT
. ..|| ..  || ..   .| |||.|. |. . ..     . . ||| || ||||. ||. .     .  .. ||       .|  |   ||..|| . 
rsvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav.rqlreeivvdvlkivcnlrldrGGmvqtseqyel

LHE
.|.
ihr
subfamily_DSP6_pd Subfamily DSP6 165-227 8.3e-07 22.7 In-house 87-150 (158) alignment 
Range on Protein: 165-227
Range on HMM: 87-150/158.0
DFAL-SHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
| |  .. |. |||.||  |.  |. |..|  | .|  .| | |..|...     . .. | .|
dearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldf
subfamily_DSP15_pd Subfamily DSP15 168-224 1.5e-06 22.4 In-house 76-132 (151) alignment 
Range on Protein: 168-224
Range on HMM: 76-132/151.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
|  ... ||| ||  |   ...|..| .. ..  .|..... .|. |       . |
lkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrql
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 156-226 1.7e-06 22.4 In-house 196-274 (318) alignment 
Range on Protein: 156-226
Range on HMM: 196-274/318.0
RLLDIVKVVDF---ALSHGKIAVHCHAGHGRTGMVIAAWMMYA-LG----MSPSQAVDTVRSRRAKAVQSKEQVKTLHE
 |||.|. |.      ..| |.||| || ||||. ||  ..   .     .   | | ..|..|   || ..| . ...
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 162-282 1.7e-06 21.7 In-house 119-246 (440) alignment 
Range on Protein: 162-282
Range on HMM: 119-246/440.0
KVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQ-----AVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGGMIIPKNKMTHISEYVAYNQK
.  .   . | . ||| || ||||..||   .        |      ....|. | . ||. ||   .||  |     |  .| .. .|.  | . . . 
nesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdtliledditerveqiqwpnp

FISKP--ESRLYGKIPKIVYIAMRITLQ
.  |   .  . |   |  .|| .. |.
htdksplqqefegyskknafiatqmpld
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 173-227 1.8e-06 21.1 In-house 83-137 (145) alignment 
Range on Protein: 173-227
Range on HMM: 83-137/145.0
IAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
. ||| ||  |.  |  |..|   .|. |.|   |||.| .|.     .|.| ..
vfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnl
subfamily_PTPN13_pd Subfamily PTPN13 139-221 2.1e-06 22.2 In-house 168-258 (273) alignment 
Range on Protein: 139-221
Range on HMM: 168-258/273.0
IYHYNFP-LPDFQA-CTPNRLLDIVK-VVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYAL-----GMSPSQAVDTVRSRRAKAVQSKEQV
. | ||   || .   ... || .|. |  .. ..| |.||| || ||.|..|.  ..  |      .  .. | ..| .|   ||.|.| 
vahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqy
subfamily_DSP10_pd Subfamily DSP10 171-214 2.9e-06 21.3 In-house 93-136 (159) alignment 
Range on Protein: 171-214
Range on HMM: 93-136/159.0
GKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKA
 .. |||.||  |   |. |..|. |..| ..| . |...|.  
srvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpii
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 121-205 4.2e-06 19.5 In-house 14-100 (128) alignment 
Range on Protein: 121-205
Range on HMM: 14-100/128.0
GNLTSGFSYDPENLMRNGIYHYNFPLPDFQAC-TPNRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVD
 | | |  .||. | .. . .|   | |..|   |.|. |  ...         . |||  |  ||| |.|...|  .| .  .|..
tnvtlgdlidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 158-227 4.2e-06 21.1 In-house 201-278 (305) alignment 
Range on Protein: 158-227
Range on HMM: 201-278/305.0
LDIVKVVDFALSHG---KIAVHCHAGHGRTGMVIAA-WMMYALGMS----PSQAVDTVRSRRAKAVQSKEQVKTLHEF
|...| |  . ...    . ||| || ||||. ||   ..  |         . . ..||.| |.||...|   ||. 
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhda
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 121-205 4.5e-06 19.4 In-house 15-101 (128) alignment 
Range on Protein: 121-205
Range on HMM: 15-101/128.0
GNLTSGFSYDPENLMRNGIYHYNFPLPDFQAC-TPNRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVD
 | | |  .||. | .. . .|   | |..|   |.|. |  ...         . |||  |  ||| |.|...|  .| .  .|..
tnvtlgdlidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 156-226 6.2e-06 20.5 In-house 199-277 (319) alignment 
Range on Protein: 156-226
Range on HMM: 199-277/319.0
RLLDIVKVVDFALSH---GKIAVHCHAGHGRTGMVIAAWMMYAlGMSP------SQAVDTVRSRRAKAVQSKEQVKTLHE
 |||..| .  . ..   | | ||| || ||||  |.  .|    ..        . | ..|  |   || .|| | ..|
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamle.rvkeegvlDvfstvsrlRtqRnimvqrpeqYkfiye
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 150-228 7e-06 20.1 In-house 173-262 (283) alignment 
Range on Protein: 150-228
Range on HMM: 173-262/283.0
QACTP----NRL--LDIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPS-----QAVDTVRSRRAKAVQSKEQVKTLHEFR
  . .    | |  .. |.       .| | ||| .| |||.. |||       .. |     . |  .| .|  |||...| | .||  
leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 168-227 7.5e-06 20.1 In-house 210-274 (315) alignment 
Range on Protein: 168-227
Range on HMM: 210-274/315.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYA-LG----MSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
 | | | |||.|| ||||  |.   .   .     .   ...  ||. | |.||. || . ... 
nsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 173-229 8.4e-06 19.9 In-house 231-292 (297) alignment 
Range on Protein: 173-229
Range on HMM: 231-292/297.0
IAVHCHAGHGRTGMVIAAWMMYAL---GMSPSQ--AVDTVRSRRAKAVQSKEQVKTLHEFRL
. ||| || ||.|.|. . .. |    .  |     .  .|..||. ||. || . |... |
llvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 172-225 9.5e-06 19.8 In-house 199-257 (270) alignment 
Range on Protein: 172-225
Range on HMM: 199-257/270.0
KIAVHCHAGHGRTGMVIAA-WMMYALGM----SPSQAVDTVRSRRAKAVQSKEQVKTLH
 . ||| || ||||..||   .. .| .     . . .. .|  | . ||  ||.. |.
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefly