Gene PTPDC1 in Caenorhabditis elegans

Synonym: CELE_T12B3.1, T12B3.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP163_AA protein Get Run
CeleP163_AA_68-232 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPDC1_pd Subfamily PTPDC1 62-233 3.6e-85 279.0 In-house 7-177 (182) alignment
Range on Protein: 62-233
Range on HMM: 7-177/182.0
EiQAIDGLYSTWITSDILAMARLQVEHFDSLGIVEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIV
| |||.||||||.|.||||.||...|..|......|||..||..||||||.|||..||.|. .||||||.|.||..|||.|||...|..... .|.||||
e.qaikGlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdiv

KVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRN
|||.|||..||.|||||||.||||..||....||  .....|...|||.|.|..|..|||....||.|.. .
kvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflip

0046846 (Phosphotyrosine protein) phosphatases II 66-232 8.2e-38 125.2 In-house 7-173 (176) alignment
Range on Protein: 66-232
Range on HMM: 7-173/176.0
IDGLYSTWITSDILAMARLQVEHFD----SLGIVEKFKTNGIQSVINLQESGEHSFCGsgnltsgFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIV
...|....|. ......|  . . .        .| .| .||. |.||.|  |.....       . .... |...|| ....| ||..... . ||...
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk.......cpnywpeleklgiqylhlpwpDhgvpdlelllell

KVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMYA-LGMSPSQAVDTVRSRRA-KAVQSKEQVKTLHEFRLLIR
. .. ||..| ...|||.||.||||...||....   |.|. .|...||..|  .|||. ||.. |.|| ||..
efirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll

0038934 (Phosphotyrosine protein) phosphatases II 71-233 2.5e-34 114.0 In-house 13-178 (194) alignment
Range on Protein: 71-233
Range on HMM: 13-178/194.0
STWITSDILAMARLQVEHFDSLgiVEKFKTNGIQSVINLQESGEHSFCGSGNLTS-GFSYDPENLMRNGIYHYNFPLPDFQAC-TPNRLLDIVKVVDF--
...|| ...|...   ...|.   .| .. ... ..... ..  .  .   .||  .. |||| ....||.....| ||. .. . . ||.....||.  
gdiitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl

-ALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRN
 . ..|..||||.||.||||...||...| ||||. .|....|..| .|... .... |...   .|.
nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk

PTEN_1 93-231 2.6e-34 113.8 In-house 47-192 (196) alignment
Range on Protein: 93-231
Range on HMM: 47-192/196.0
GIVEKFKTNGIQSVINLQESGEHSFCGSGNLT--SGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGM
|  ... .   . . ||.|.| .. .   .    ||.|||.|  ...|. ...|| .|..|.. ..|.||.|... .|.    .....|||.||.||.|.
glyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGt

VIAAWMMYALGMSPSQAVDTVRSRR-AKAVQSKEQVKTLHEFRLLI
|.||..||. .... .|.. ||..| . |..| .| . |..|. | 
vvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell

0043147 (Phosphotyrosine protein) phosphatases II 70-232 6.7e-34 112.5 In-house 14-161 (172) alignment
Range on Protein: 70-232
Range on HMM: 14-161/172.0
YSTWITSDILAMARLQVEHFDSLgiVEKFKTNGIQSVINLQESgehsfcgsgnltsgfSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDF---
. ..|. ...|.  .  .....   .. .|..||. ..|| |                 ||||.|.|.|| .. .| ||. ..... ||.... .|    
dlyyipdrfiatqgplrntladf..wrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidella

ALSHGKIAVHCHAGHGRTGMVIAAWMMYaLGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIR
  ..|...|||.|| ||||...||..|. ||.|. .||..||..| .|||...| . |..|  |..
lspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll

0044763 (Phosphotyrosine protein) phosphatases II 57-235 2.1e-33 110.8 In-house 9-174 (178) alignment
Range on Protein: 57-235
Range on HMM: 9-174/178.0
VTGQTEIQAIDGLYSTWITSDILAMARLQvehfdsLGIVEKFKTNGIQSVINLQESGEHSFCGsgnltsgfsYDPENLMRNGIYHYNFPLPDFQACT-PN
..    ....|... ..|. ......  .         .| .| .||....|| |  |. |..         .||. ....|| ....|.||. ... . 
lsnleglersdyinaseilpglylgslpp......addlellkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdlle

RLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAkAVQSKEQVKTLHEFRLLIRNNG
 .|..|. .. |   ..|...|||.|| ||.|...||..|. ||.|. .|.. ||.||  .|.. .|.. |.|| | .....
hflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes

0036282 (Phosphotyrosine protein) phosphatases II 72-232 4.3e-33 109.8 In-house 13-170 (174) alignment
Range on Protein: 72-232
Range on HMM: 13-170/174.0
TWITSDILAMARLQVehfdslgIVEKFKTNGIQSVINLQESGEHSFCGSGNLTSGfsyDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALSH-
..||. ..|..            .| .| .||..|..| |. |   ..  |...    ..| | |.|| .. .| ||... . . ||..|| |. |||. 
syitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpe...lredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

--GKIAVHCHAGHGRTGMVIAAWMMYALGM-SPSQAVDTVRSRR---AKAVQSKEQVKTLHEFRLLIR
  |...|||.|| ||||...||..|. ... |. .|.|.||..|    ..||. .| . |..|. |..
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls

0041856 (Phosphotyrosine protein) phosphatases II 68-236 2e-32 107.6 In-house 16-175 (182) alignment
Range on Protein: 68-236
Range on HMM: 16-175/182.0
GLYSTWITSDILAMARLQVEHFDS--------LGIVEKFKTNGIQSVINLQesgehsfcgsgnltsGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLD
......|.  ...... . .               .. .| .||....||                .. |.||.|.|.|| ....| ||. ..... |||
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...............eelywpellerlgiqylylpwpDhgvpdldelld

IVKVVDFalSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGG
... |    ..|...|||.|| ||||...||..|. ||.|. .||..||||| ..|.. .|   |. . |... .. 
fieevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

0048076 (Phosphotyrosine protein) phosphatases II 95-230 8e-30 98.8 In-house 22-141 (145) alignment
Range on Protein: 95-230
Range on HMM: 22-141/145.0
VEKFKTNGIQSVINLqesgehsfcgsgnltsgfSYDPENLMRNGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWM
.| .| .||  |.||                  ....|.| |.|| ....|.||... .  . ||.... .. ||..| ...|||.|| ||||...||..
lellkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLL
|. ||.|. .|.. |||.| .||.. .|.. |.|| | 
mlllgvsleealelvrsqrpgavpnpgqlrflyefele

0045098 (Phosphotyrosine protein) phosphatases II 96-234 6.3e-29 96.6 In-house 82-274 (278) alignment
Range on Protein: 96-234
Range on HMM: 82-274/278.0
EKFKTNGIQSVINLQESGEHSFCGSGNLTSG-------------------------------FSYDPENLMRNGIYHYNF-PLPDFQACTPN---RLLDI
. .. .||.....| |  | . .                                       ... .|.|. .|..|... | ||. . . .    .|..
rmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflel

VKVVDFAL---------------SHGKIAVHCHAGHGRTGMVIAAWMMYAL---GMSPSQAVDTVRSRRAK-AVQSKEQVKTLHEFRLLIRNN
.. .. ||               |.|...|||.|| ||||...||..|. |   |... .||...||.|   |||..|| . |.|| |.....
lefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr

0048179 (Phosphotyrosine protein) phosphatases II 95-227 7.9e-29 95.6 In-house 22-140 (144) alignment
Range on Protein: 95-227
Range on HMM: 22-140/144.0
VEKFKTNGIQSVINLQESGEHSFCGSGnltsgfsydpenlmrnGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALS-HGKIAVHCHAGHGRTGMVIAAWM
.| .| .||  ||||.|. |. |..                  || ....|.||... .  . ||.... .. ||. .|...|||.|| ||||...||..
lellkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
|. ||.|. .|.. |||||  ||.. .|.. |.|.
mkklglsleealalvrsrrpgavpnpgqlrfLley

0037934 (Phosphotyrosine protein) phosphatases II 96-230 5.2e-28 93.7 In-house 66-240 (243) alignment
Range on Protein: 96-230
Range on HMM: 66-240/243.0
EKFKTNGIQSVINLQESGEHSFCGSGNLTS---------------------------GFSYDPENLMRNGIYHYNFPLPDFQACT-PNRLLDIVKVVD--
. .. .||.....| |  |.. ..   . .                              .|...| |..| .. .| ||... . |. |||... |   
rmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevref

--------FALSHGKIAVHCHAGHGRTGMVIAAWMMYAL-GMSPSQAVDTVRSRRAK-AVQSKEQVKTLHEFRLL
         . |.|...|||.|| ||||..|||..|. | |... .||...|..|   |||. .| . |.|. | 
ieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle

0049260 (Phosphotyrosine protein) phosphatases II 96-228 9.6e-28 92.2 In-house 27-146 (152) alignment
Range on Protein: 96-228
Range on HMM: 27-146/152.0
EKFKTNGIQSVINLQESGEHSFCGSGNLTsgfsydpenlmrngiYHYNFPLPDFQACTPNRLLDIVKVVD---FALSHGKIAVHCHAGHGRTGMVIAAWM
. .|..||. ...| |  |  ...  ..                 ....| ||. ...   ||...  ..      ..|...|||.|| ||||...||..
rmlkelgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

MYaLGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
|. ||.|. .||. ||..| .||....| . |.|| 
ml.lgvsleeavalvrekRpgavpnpgqlrflyefe

0042113 (Phosphotyrosine protein) phosphatases II 95-229 9.9e-28 92.6 In-house 65-240 (245) alignment
Range on Protein: 95-229
Range on HMM: 65-240/245.0
VE----KFKTNGIQSVINLQESGEHSFCGSGNLTSG----------------------------FSYDPENLMRNGIYHYNFPLPDFQACT-PNRLLDIV
||     .. .||.....| |  |......    .                              ......  |..| .. .| ||..... .. |||..
vedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfl

KVVDFALS---HGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRL
. |. ||.   .|...|||.|| ||||..|||..|     . ||.|. .||. .||.| .|||. .| . |.|. |
efvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

0040439 (Phosphotyrosine protein) phosphatases II 98-231 2.1e-27 91.8 In-house 74-245 (249) alignment
Range on Protein: 98-231
Range on HMM: 74-245/249.0
FKTNGIQSVINLQESGEHSFCGSG------------------------------NLTSGFSYDPENLMRNGIYHYNFPlpDFQAC-TPNRLLDIVKVVDF
.. .||.....| .  |. ...                                .|.  ..||.| .. ..|.....|  |.... ... |||... |. 
lwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrk

AL----SHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLI
||    ..|...|||.|| ||||..|||..|     . ||... .||...||.| .|||. || . |.|. | .
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0039614 (Phosphotyrosine protein) phosphatases II 95-234 3.8e-27 90.9 In-house 118-291 (297) alignment
Range on Protein: 95-234
Range on HMM: 118-291/297.0
VEKFKTNGIQSVINLQESGEHSF-CGSGNLTSGFSYD------PENLMRNGIYHYNFPL-----------------PDFQAC-TPNRLLDIVKVVDFAL-
 . .. .|......| .  |..  | .   ..|  |.       .  ...|........                 ||.... ... ||.... |. || 
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---SHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNN
   ..|...|||.|| ||||..|||..|     .  |... .||...|..| .|||. .| . |... |  ...
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0040438 (Phosphotyrosine protein) phosphatases II 98-244 1.2e-26 89.1 In-house 106-288 (317) alignment
Range on Protein: 98-244
Range on HMM: 106-288/317.0
FKTNGIQSVINLQESGEhsfcgsgnltsgF------SY--------------------DpenlmRNGIYHYNFPL-------------------PDFQAC
.. .|......| |. |            .       |                           .|| ......                   ||. . 
vweqgvtvivmLtelee............lgrekcaqYwplgetltygdftvtllseee.....lagitlrtlevedlgdsesrtvthfhytgWpdhgvp

-TPNRLLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGGMIIPKNKM
 .|. |||... |. ||.  .|...|||.|| ||||..|||..|     .  |... .||...|..|..|||. || . |... | . ..... .| .. 
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel





0049772 (Phosphotyrosine protein) phosphatases II 102-228 3.9e-26 87.9 In-house 155-270 (314) alignment
Range on Protein: 102-228
Range on HMM: 155-270/314.0
GiqsvinlqesGEHSFCGSGNLTsGFSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALSHGKIAVHCHAGHGRTG-MVIAAWMMYALGMSP
|          .| ...   .|  .  |||| . |.|| ....|.||..| ... ......... |  .|...|||.|| |||| .|.||..|..||.|.
g..........neptaadlellk.eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

SQAVDTVRSRRAkAVQSKEQVKTLHEFR
 .|.. ||..|  .  .. ....| .. 
eealedvrlkRp.inpnpgfieqleqye

0043336 (Phosphotyrosine protein) phosphatases II 98-228 1.2e-25 86.0 In-house 108-273 (278) alignment
Range on Protein: 98-228
Range on HMM: 108-273/278.0
FKTNGIQSVINLQESGEHSFCG-----------------------------SGNLTSGFSYDPENLMRNGIYHYNFPlpDFQAC-TPNRLLDIVKVVDFA
.. .|......| |  |.. ..                               .|.    .|.| .. ........|  |.... ... |||..|.|. |
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrea

L--SHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
|  |.|...|||.|| ||||..||....     . .|... .||...|..|..|||. .| . |.|. 
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

0045450 (Phosphotyrosine protein) phosphatases II 98-230 2.2e-25 85.5 In-house 127-302 (307) alignment
Range on Protein: 98-230
Range on HMM: 127-302/307.0
FKTNGIQSVINLQESGEHSFC---------------------------GSGNLTSGFSYDPENLMRNGIYHYNFPL---PDFQAC-TPNRLLDIVKVVDF
.. .|.. ...| |. |. .                             .|     .   . .   ...... |.    ||.... ... |||... |. 
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

AL----SHGKIAVHCHAGHGRTGMVIAAWMMYALG--------MSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLL
||    ..|...|||.|| ||||..|||..|. ..        ... .||...|..| .|||. || . |.|. | 
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0051082 (Phosphotyrosine protein) phosphatases II 72-225 5.6e-24 79.9 In-house 9-146 (151) alignment
Range on Protein: 72-225
Range on HMM: 9-146/151.0
TWITSDILAMARLqVEhfdslGIVEKFKTNGIQSVINLQESGEHSfcgsgnltsgfsYDPENLMRNGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALS-
...|. ..... .  .       .| .|..||....|| .  |.             |.|| | ..|| ....|..|... .    .  ........|. 
syvtgglyrsggp.la.....dflellkelgiktivnlrseeerg............ycpeylpelgievlhipildwpdpglplsfdavleflellldk

-HGKIAVHCHAGHGRTGMVIAAWMMYaLGMSPSQAVDTVRSRRAKAVQSKEQVKTLH
 .|...|||.|| ||||...|...|. ||.|. .|.. .|..|  .||...|   ..
kngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfql

0051429 (Phosphotyrosine protein) phosphatases II 97-229 7.1e-24 80.3 In-house 40-222 (272) alignment
Range on Protein: 97-229
Range on HMM: 40-222/272.0
KFKTNGIQSVINLQESGEHSFCGSGNLTsgfsydpenlmrNGIYHYNFPLPDFQACTPN-----------------------------------------
..|..|| ....| .  |. ...   .              || ....|..|. | |..                                         
rlkelgiktivdLrseeErgrlkcdryw............pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

----------RLldIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYaLGMS--------------PSQAVDTVRSRRAKAVQSKEQVKTLHEFRL
              ....... |..|.. |||.|| .|||.|.|..... ||.|              . .||. .|..|..|||. ||.. |.|. |
tdwpdhgvpqea..llellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall

0036941 (Phosphotyrosine protein) phosphatases II 139-244 1.5e-22 75.7 In-house 170-289 (297) alignment
Range on Protein: 139-244
Range on HMM: 170-289/297.0
IYHYNFP-LPDFQACT-PNRLLDIVKVVDFAL----SHGKIAVHCHAGHGRTGMVIAAWMM--------YALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
..|. ..  ||. . . |. |||... |. .|    |.|.. |||.|| ||.|..|||..|        .  |... .|| ..|..|. |||. || . |
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

HEFRLLIRNNGGMIIPKNKM
.|. |   ... ...| .|.
yeallellkkkltkepllkl

0047943 (Phosphotyrosine protein) phosphatases II 139-227 1.3e-21 72.8 In-house 168-267 (273) alignment
Range on Protein: 139-227
Range on HMM: 168-267/273.0
IYHYNFP-LPDFQAC-TPNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
..|. ..  ||.... ... ||.....|. ||.    .|...|||.|| ||||..||....     .  |... .||  .||.|  .||. || . |.|.
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea





0046845 (Phosphotyrosine protein) phosphatases II 139-230 2.5e-21 71.8 In-house 167-272 (284) alignment
Range on Protein: 139-230
Range on HMM: 167-272/284.0
IYHYNF-PLPDFQACT-PNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGMVIAAWMMYAL--------GMSPSQAVDTVRSRRAKAVQSKEQVKTL
..|. . . ||..... |. ||.... |. .|.    .|.|.|||.|| ||||..||..... .        |... .||  .|..|  .||. || . .
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

HEFRLL
.|. | 
yealle

0050432 (Phosphotyrosine protein) phosphatases II 139-229 1.3e-20 69.5 In-house 199-296 (308) alignment
Range on Protein: 139-229
Range on HMM: 199-296/308.0
IYHYNFPL-PDFQACT-PNRLLDIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRL
..|. ..  ||..... |. |||... |.  |..|.|.|||.||.|||| .||....     .  |... .|| ..|..|. .||..|| . |..  |
vthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

0051299 (Phosphotyrosine protein) phosphatases II 133-226 3.3e-19 64.9 In-house 179-280 (288) alignment
Range on Protein: 133-226
Range on HMM: 179-280/288.0
NLMRNGIYHYNFPLPDFQACT-PNRLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMM-----YALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
.  |. . .. .  ||... . |. |||... |. |   ..| ..|||.|| ||||..||....     .  |... .|| ..|..|  .||. || . .
gesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv

HE
.|
ye

DSPc Dual specificity phosphatase, catalytic domain 96-228 9.8e-17 56.1 Pfam-A 12-131 (133) alignment
Range on Protein: 96-228
Range on HMM: 12-131/133.0
EKFKTNGIQSVINLQESGEHSfcgsgnltsgfsydpENLMRNGIYHYNFPLPD-FQACTPNRLLDIVKVVDFAL-SHGKIAVHCHAGHGRTGMVIAAWMM
.. . .||. |||.... ...                    . | . . |. |  .. . . | ..|.... |  ...|..||| ||  |....|.|..|
alleklgitlvinvtkevpnn...............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm

YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.  ..| ..|.. |..|| | ... .....| |..
ktknlslneAyefvkerrskispnagflrqLleye

DSPc Dual specificity phosphatase, catalytic domain 96-228 9.8e-17 56.1 In-house 12-131 (133) alignment
Range on Protein: 96-228
Range on HMM: 12-131/133.0
EKFKTNGIQSVINLQESGEHSfcgsgnltsgfsydpENLMRNGIYHYNFPLPD-FQACTPNRLLDIVKVVDFAL-SHGKIAVHCHAGHGRTGMVIAAWMM
.. . .||. |||.... ...                    . | . . |. |  .. . . | ..|.... |  ...|..||| ||  |....|.|..|
alleklgitlvinvtkevpnn...............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm

YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.  ..| ..|.. |..|| | ... .....| |..
ktknlslneAyefvkerrskispnagflrqLleye

subfamily_PTPMT1_pd Subfamily PTPMT1 132-228 1.5e-16 55.3 In-house 67-165 (171) alignment
Range on Protein: 132-228
Range on HMM: 67-165/171.0
ENLMRNGIYHYNFPLPDFQ-ACTPNRLLDIVKVVDFALSHGK-IAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
|.  ..|. ..... .||  | . ..|.. |....   |.|| . |||.||.||.. ..|...|.   .|| .|.......| .    |.|.|.|.|..
eewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye

PTPc_motif_SM00404 96-228 2.1e-16 55.1 In-house 21-138 (140) alignment
Range on Protein: 96-228
Range on HMM: 21-138/140.0
EKFKTNGIQSVINLQESGEHSfcgsgnltsgfsydpenLMRNGIYHYNFPLPD-FQACTPNRLLDIVKVVDFAL-SHGKIAVHCHAGHGRTGMVIAAWMM
.. | .||. |||..|. . .                    .|. . . || |  .. . . |  ...... |  ..||. ||| ||  |....|.|..|
allkklgithvinvteevslt.................kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

YALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.  ..| ..|.. |..|| .  .. . |..|.|..
ryrqlslaeayefvkerRpiispnlnfvrqLieye

subfamily_CDC14_pd Subfamily CDC14 94-220 2.9e-16 54.2 In-house 204-313 (328) alignment
Range on Protein: 94-220
Range on HMM: 204-313/328.0
IVEKFKTNGIQSVINLQESgehsfcgsgnltsgfSYDPENLMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFAlsHGKIAVHCHAGHGRTGMVIAAWMM
..| |..|....|. | .                 || ..   .|. |..    |    . . .   ..... |  .|.|||||.|| |||| .||...|
lleyfrknnvttvvrLnkk...............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka..eGaiavhCkaGLGrtGtLiacylm

YALGMSPSQAVDTVRSRRAKAVQSKEQ
.  ... ..|.  .|  |   | .. |
khyrftaaeaiawlricrPGsvigpqq

subfamily_DSP23_pd Subfamily DSP23 140-231 6.7e-14 46.8 In-house 53-145 (148) alignment
Range on Protein: 140-231
Range on HMM: 53-145/148.0
YHYNFPLPDFQACTPNRLLDIVKVVDFALSHGK-IAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLI
  ... ..|..  ..... ..|.||. | .... ..|||  |.|||| ..| ...   ... ..|.  || .|  .|.. || | ....  .|
tlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi

0048567 (Phosphotyrosine protein) phosphatases II 165-231 1.4e-13 45.5 In-house 64-138 (157) alignment
Range on Protein: 165-231
Range on HMM: 64-138/157.0
D-----FALSHGKIAVHCHAGH---GRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFRLLI
.     . | ...|||||.||    |||...|...... ||..|..|.. .|  | . |   ..   |. . |..
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltl

PTPc_DSPc_SM00012 146-226 4.3e-13 44.7 In-house 10-101 (105) alignment
Range on Protein: 146-226
Range on HMM: 10-101/105.0
LPDFQAC-TPNRLLDIVKVVDFALS----HGKIAVHCHAGHGRTGMVIAAWMMYAL----G--MSPSQAVDTVRSRRAKAVQSKEQVKTLHE
 ||...  ... .|.... |.   .    .. . |||.|| ||||...|. ...         .. .| |  .|..|...||..||.  |..
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

subfamily_PTEN_pd Subfamily PTEN 72-227 9.2e-13 43.6 In-house 23-175 (184) alignment
Range on Protein: 72-227
Range on HMM: 23-175/184.0
TWITSDILAMArlqvehFDSlGIVEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYDPENLmRNGIYHYnfPLPDFQACTPNRLLDIVKVVDFALSHG
..||. |.||.      . .   .|.   | .. |... |.  .      ||.|. .|| ... .. . .|  |. | .. . . | .||. ..  |.. 
syiteniiamg......yPa.eklealyRnsledvvkflekkhkdhykiynlrserkydskkf.dgrvavy..pfdDhnppplelleeivediekwleed

K---IAVHCHAGHGRTGMVIAAWMMYALGMSPS-QAVDT---VRSRRAKAVQSKEQVKTLHEF
|   ..|||.||.||||..|.|.....| .. . .|..    .|.. .|.|.   | . .. .
kknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy

subfamily_PRL_pd Subfamily PRL 128-228 6.2e-12 39.8 In-house 45-146 (151) alignment
Range on Protein: 128-228
Range on HMM: 45-146/151.0
SYDPENLMRNGIYHYNFPLPDFQACTPN---RLLDIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMyALGMSPSQAVDTVRSRRAKAVQSKeQVKTL
.|| |.| ..||   .... | .. . .   . |...|      ..  .|||| || ||. ...|  ..   ||.. .||. .|..|  |. || |.| |
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali.eaGmkyedavefirekrrgainsk.qlkfl

HEFR
....
ekyk

Y_phosphatase Protein-tyrosine phosphatase 148-226 9.3e-12 40.2 Pfam-A 145-231 (235) alignment
Range on Protein: 148-226
Range on HMM: 145-231/235.0
DFQAC-TPNRLLDIVKVVDFAL--SHGKIAVHCHAGHGRTGMVIAAWMMYALGMS-----PSQAVDTVRSRRAKAVQSKEQVKTLHE
| ..  .|. |||... |      ..|.. ||| || ||||...|....     .       |.| ..|..|...||| || . |..
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk

Y_phosphatase Protein-tyrosine phosphatase 148-226 9.3e-12 40.2 In-house 145-231 (235) alignment
Range on Protein: 148-226
Range on HMM: 145-231/235.0
DFQAC-TPNRLLDIVKVVDFAL--SHGKIAVHCHAGHGRTGMVIAAWMMYALGMS-----PSQAVDTVRSRRAKAVQSKEQVKTLHE
| ..  .|. |||... |      ..|.. ||| || ||||...|....     .       |.| ..|..|...||| || . |..
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk

subfamily_CDKN3_pd Subfamily CDKN3 98-229 1.5e-11 38.2 In-house 66-193 (202) alignment
Range on Protein: 98-229
Range on HMM: 66-193/202.0
FKTNGIQSVINLQESGEHSFCGSGNLTSGFsydpenlMRNGIYHYNFPLPDFQACTPNRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMY-A
.|. |.. |. |   || |     .|   .        . |.  . .|..|  .  .   |.|.. .  .|  . |  |||. | ||. .|||  ..|  
lksqgvedvfvlctrgelskyrvrrlldly.......qqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllyld

LGMSPSQAVDTVRSRR-AKAVQSKEQVKTLHEFRL
  ..| .|.| .|  . ..|.|.  |   |.||| 
dtiepkdaidklrdlkgsraiqtvkqynylsefrd

DSPc_SM00195 147-227 9.1e-10 33.7 In-house 169-257 (263) alignment
Range on Protein: 147-227
Range on HMM: 169-257/263.0
PDFQAC-TPNRLLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMMYALG-----MSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
|| ..  ... .|.....|.   |  .| | |||.|| ||||..... ...        .. .. |  .|. |...||..|| ....| 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea

PTPc_SM00194 147-227 9.1e-10 33.7 In-house 169-257 (263) alignment
Range on Protein: 147-227
Range on HMM: 169-257/263.0
PDFQAC-TPNRLLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMMYALG-----MSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
|| ..  ... .|.....|.   |  .| | |||.|| ||||..... ...        .. .. |  .|. |...||..|| ....| 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea

subfamily_DSP3_pd Subfamily DSP3 143-212 2.8e-09 30.8 In-house 67-139 (162) alignment
Range on Protein: 143-212
Range on HMM: 67-139/162.0
NFPLPDFQACTPNRL-LDIVKVVDFALSH--GKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRA
 ... |....  ..     .| .| |||.  ||. |||..|  |   .. |..|    |.  .|. |||..|.
GlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe

subfamily_DSP12_pd Subfamily DSP12 164-228 3.3e-09 31.3 In-house 75-140 (155) alignment
Range on Protein: 164-228
Range on HMM: 75-140/155.0
VDFAL-SHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEFR
.. ||  .|.. |||.||  |   ...|..|.  ..| ..|...|.. . ..   .  .. |. |.
ieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfe

subfamily_PTPRK_pd Subfamily PTPRK 156-244 9.9e-09 29.4 In-house 194-289 (314) alignment
Range on Protein: 156-244
Range on HMM: 194-289/314.0
RLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSP-----SQAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGGMIIPKNKM
 ||..|. |.     ..|.| ||| || ||||. ||  ..  .          .|| |.|||.   |. .|| | ...  |     |   ||  ..
gllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsef

subfamily_CG42327_pd Subfamily CG42327 169-223 2e-08 28.3 In-house 246-306 (319) alignment
Range on Protein: 169-223
Range on HMM: 246-306/319.0
SHGKIAVHCHAGHGRTGMVIAAWM-MYALGMS-----PSQAVDTVRSRRAKAVQSKEQVKT
|.| ..|||  | ||||.|||. . .  |  |       | |  ||  ||.||..||| . 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyef

subfamily_Tensin_pd Subfamily Tensin 126-210 3.4e-08 26.2 In-house 60-145 (189) alignment
Range on Protein: 126-210
Range on HMM: 60-145/189.0
GFSYDPENLMRNgIyhYNFPLPDFQACTPNRLLDIVKVVDFALSHG---KIAVHCHAGHGRTGMVIAAWMMYA-LGMSPSQAVDTVRSR
  .|| ..| .. .   .|  || .| . ..|  |.| .|  |..     ..|||. |.||.|.|..|.| |. .  | ..|.|.   .
ekrydisklnkk.v..ldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamk

subfamily_DSP19_pd Subfamily DSP19 161-215 5e-08 27.4 In-house 79-134 (152) alignment
Range on Protein: 161-215
Range on HMM: 79-134/152.0
VKVVDFALSH-GKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAV
.. .. |.|. | . |||.||  |.  |. |..|    .| ..|...||. |  . 
ldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcik

subfamily_DSP8_pd Subfamily DSP8 168-215 5e-08 26.7 In-house 91-138 (159) alignment
Range on Protein: 168-215
Range on HMM: 91-138/159.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAV
 ..|.. ||..||. |   |. |..|  | ||  .|   |...|.   
sengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptis

subfamily_DSP1_pd Subfamily DSP1 168-213 5.7e-08 27.0 In-house 93-138 (163) alignment
Range on Protein: 168-213
Range on HMM: 93-138/163.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAK
 ..||. .||.||  |   .. |..|    .| ..| | |..||. 
kknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi

subfamily_RNGTT_pd Subfamily RNGTT 168-224 6.2e-08 26.5 In-house 111-167 (189) alignment
Range on Protein: 168-224
Range on HMM: 111-167/189.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
 ..  |.|||. |. ||| .|.....    .| ..||.. .. | . .  .. .| |
npeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkel

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 157-234 7.1e-08 26.8 In-house 197-281 (288) alignment
Range on Protein: 157-234
Range on HMM: 197-281/288.0
LLDIVKVVDFALS--HGKIAVHCHAGHGRTGMVIAAWMMYALgMSPS------QAVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNN
||.... |. | .   |.| ||| || ||||  ||. ..    .  .       .|  .| .||  || ..|   ..|  | . ..
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalida.veeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

subfamily_Laforin_pd Subfamily Laforin 95-215 8.6e-08 25.3 In-house 30-155 (183) alignment
Range on Protein: 95-215
Range on HMM: 30-155/183.0
VEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYdPEN---LMR-NGIYHYNFPLPDFQACTP-NRLLDIVKVVDFALSHGK-IAVHCHAGHGRTGMVI
| ..|..|| .||.|| . .     ||      .  |.    | . .|. .  .|..|. . .  . | . | ..   | .|. . ||| || ||.  ..
vidlksegitavislqtesdivknssgiyrynenl.pitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaiv

AAWMMYALGMSPSQAVDTVRSRRAKAV
  ...| || | ..    . ..|  . 
cgflqyvlgwslakvqyfllakrpvvy

subfamily_DSP11_pd Subfamily DSP11 170-226 9.5e-08 26.1 In-house 116-172 (178) alignment
Range on Protein: 170-226
Range on HMM: 116-172/178.0
HGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHE
   |.|||  |  ||| .|  ...   |..|..|...  . |  ... .. .| |..
dkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk

subfamily_PTPN12_pd Subfamily PTPN12 147-226 1.9e-07 25.3 In-house 181-271 (290) alignment
Range on Protein: 147-226
Range on HMM: 181-271/290.0
PDFQAC-TPNRLLDIVKVVDFALSHG--KIAVHCHAGHGRTGMVIA---AWMMYALGMSPS-----QAVDTVRSRRAKAVQSKEQVKTLHE
|| .   ....||.... |    ..    ..||| || |||| .||   ....   .. |.     . | ..| .|| .||.||| . ...
PDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyk

subfamily_VSP_pd Subfamily VSP 72-217 2.7e-07 24.7 In-house 37-176 (212) alignment
Range on Protein: 72-217
Range on HMM: 37-176/212.0
TWITSDILAMArlqvehFDSLGIvEKFKTNGIQSVINLQESGEHSFCGSGNLTSGFSYDPENLmRNGIYhyNFPLPDFQACTPNRLLDIVKVVDFALSHG
|..|  |.||.      | | |  ...  | |. |  . .   .      || |  .||.. . .| .   .  . | .  . ..|| . | |   |.. 
tyvteriiams......fpssGk.qslyrnpisevarfldtkhrdhykvvnlcseraydekyf.nnrvk..riliddhnvpkleellvftkevkewlekd

---KIAVHCHAGHGRTGMVIAAWMMYALGMSP-SQAVDTVRSRRAKAVQS
    .|.||  |.|||| .. |.....  ..   ...|   .||..  ..
lknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdkteg

subfamily_PTPRA_pd Subfamily PTPRA 152-222 5.3e-07 23.8 In-house 208-285 (330) alignment
Range on Protein: 152-222
Range on HMM: 208-285/330.0
CTPNRLLDIVKVVDFA--LSHGKIAVHCHAGHGRTGMVIAAWMMYA----LG-MSPSQAVDTVRSRRAKAVQSKEQVK
 .|  .|...| |      | | | ||| || ||||  |.   . .     . .   ..|  .| .|.. ||..|| .
fepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqye

subfamily_PTPRB_pd Subfamily PTPRB 139-227 6e-07 23.8 In-house 181-280 (293) alignment
Range on Protein: 139-227
Range on HMM: 181-280/293.0
IYHYNFP-LPDFQAC-TPNRLLDIVKVVDFAL----SHGKIAVHCHAGHGRTGMVIAAWMMYAlGMSPSQA------VDTVRSRRAKAVQSKEQVKTLHE
. .|.|   ||.    ... |||.|. |. |.    |.. | ||| || ||||  ||  ..    .. ..       |  .|..|.  ||...|   .|.
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllq.aieeedyvdifgivaelReeRnllvqtekqYifihq

F
 
c

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 137-226 6.2e-07 23.8 In-house 161-262 (274) alignment
Range on Protein: 137-226
Range on HMM: 161-262/274.0
NGIYHYNFP-LPDFQAC-TPNRLLDIVKVVDFALSH-----GKIAVHCHAGHGRTGMVIAAWMMYaLGMSPSQAVDT------VRSRRAKAVQSKEQVKT
. ..|| ..  || ..   .| |||.|. |. . ..     . . ||| || ||||. ||. .     .  .. ||       .|  |   ||..|| . 
rsvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav.rqlreeivvdvlkivcnlrldrGGmvqtseqyel

LHE
.|.
ihr

subfamily_DSP6_pd Subfamily DSP6 165-227 8.3e-07 22.7 In-house 87-150 (158) alignment
Range on Protein: 165-227
Range on HMM: 87-150/158.0
DFAL-SHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
| |  .. |. |||.||  |.  |. |..|  | .|  .| | |..|...     . .. | .|
dearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldf

subfamily_DSP15_pd Subfamily DSP15 168-224 1.5e-06 22.4 In-house 76-132 (151) alignment
Range on Protein: 168-224
Range on HMM: 76-132/151.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTL
|  ... ||| ||  |   ...|..| .. ..  .|..... .|. |       . |
lkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrql

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 156-226 1.7e-06 22.4 In-house 196-274 (318) alignment
Range on Protein: 156-226
Range on HMM: 196-274/318.0
RLLDIVKVVDF---ALSHGKIAVHCHAGHGRTGMVIAAWMMYA-LG----MSPSQAVDTVRSRRAKAVQSKEQVKTLHE
 |||.|. |.      ..| |.||| || ||||. ||  ..   .     .   | | ..|..|   || ..| . ...
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 162-282 1.7e-06 21.7 In-house 119-246 (440) alignment
Range on Protein: 162-282
Range on HMM: 119-246/440.0
KVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQ-----AVDTVRSRRAKAVQSKEQVKTLHEFRLLIRNNGGMIIPKNKMTHISEYVAYNQK
.  .   . | . ||| || ||||..||   .        |      ....|. | . ||. ||   .||  |     |  .| .. .|.  | . . . 
nesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdtliledditerveqiqwpnp

FISKP--ESRLYGKIPKIVYIAMRITLQ
.  |   .  . |   |  .|| .. |.
htdksplqqefegyskknafiatqmpld

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 173-227 1.8e-06 21.1 In-house 83-137 (145) alignment
Range on Protein: 173-227
Range on HMM: 83-137/145.0
IAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
. ||| ||  |.  |  |..|   .|. |.|   |||.| .|.     .|.| ..
vfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnl

subfamily_PTPN13_pd Subfamily PTPN13 139-221 2.1e-06 22.2 In-house 168-258 (273) alignment
Range on Protein: 139-221
Range on HMM: 168-258/273.0
IYHYNFP-LPDFQA-CTPNRLLDIVK-VVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYAL-----GMSPSQAVDTVRSRRAKAVQSKEQV
. | ||   || .   ... || .|. |  .. ..| |.||| || ||.|..|.  ..  |      .  .. | ..| .|   ||.|.| 
vahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqy

subfamily_DSP10_pd Subfamily DSP10 171-214 2.9e-06 21.3 In-house 93-136 (159) alignment
Range on Protein: 171-214
Range on HMM: 93-136/159.0
GKIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVDTVRSRRAKA
 .. |||.||  |   |. |..|. |..| ..| . |...|.  
srvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpii

subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 121-205 4.2e-06 19.5 In-house 14-100 (128) alignment
Range on Protein: 121-205
Range on HMM: 14-100/128.0
GNLTSGFSYDPENLMRNGIYHYNFPLPDFQAC-TPNRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVD
 | | |  .||. | .. . .|   | |..|   |.|. |  ...         . |||  |  ||| |.|...|  .| .  .|..
tnvtlgdlidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 158-227 4.2e-06 21.1 In-house 201-278 (305) alignment
Range on Protein: 158-227
Range on HMM: 201-278/305.0
LDIVKVVDFALSHG---KIAVHCHAGHGRTGMVIAA-WMMYALGMS----PSQAVDTVRSRRAKAVQSKEQVKTLHEF
|...| |  . ...    . ||| || ||||. ||   ..  |         . . ..||.| |.||...|   ||. 
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhda

subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 121-205 4.5e-06 19.4 In-house 15-101 (128) alignment
Range on Protein: 121-205
Range on HMM: 15-101/128.0
GNLTSGFSYDPENLMRNGIYHYNFPLPDFQAC-TPNRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMYALGMSPSQAVD
 | | |  .||. | .. . .|   | |..|   |.|. |  ...         . |||  |  ||| |.|...|  .| .  .|..
tnvtlgdlidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 156-226 6.2e-06 20.5 In-house 199-277 (319) alignment
Range on Protein: 156-226
Range on HMM: 199-277/319.0
RLLDIVKVVDFALSH---GKIAVHCHAGHGRTGMVIAAWMMYAlGMSP------SQAVDTVRSRRAKAVQSKEQVKTLHE
 |||..| .  . ..   | | ||| || ||||  |.  .|    ..        . | ..|  |   || .|| | ..|
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamle.rvkeegvlDvfstvsrlRtqRnimvqrpeqYkfiye

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 150-228 7e-06 20.1 In-house 173-262 (283) alignment
Range on Protein: 150-228
Range on HMM: 173-262/283.0
QACTP----NRL--LDIVKVVDFALSHGKIAVHCHAGHGRTGMVIAAWMMYALGMSPS-----QAVDTVRSRRAKAVQSKEQVKTLHEFR
  . .    | |  .. |.       .| | ||| .| |||.. |||       .. |     . |  .| .|  |||...| | .||  
leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 168-227 7.5e-06 20.1 In-house 210-274 (315) alignment
Range on Protein: 168-227
Range on HMM: 210-274/315.0
LSHGKIAVHCHAGHGRTGMVIAAWMMYA-LG----MSPSQAVDTVRSRRAKAVQSKEQVKTLHEF
 | | | |||.|| ||||  |.   .   .     .   ...  ||. | |.||. || . ... 
nsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 173-229 8.4e-06 19.9 In-house 231-292 (297) alignment
Range on Protein: 173-229
Range on HMM: 231-292/297.0
IAVHCHAGHGRTGMVIAAWMMYAL---GMSPSQ--AVDTVRSRRAKAVQSKEQVKTLHEFRL
. ||| || ||.|.|. . .. |    .  |     .  .|..||. ||. || . |... |
llvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 172-225 9.5e-06 19.8 In-house 199-257 (270) alignment
Range on Protein: 172-225
Range on HMM: 199-257/270.0
KIAVHCHAGHGRTGMVIAA-WMMYALGM----SPSQAVDTVRSRRAKAVQSKEQVKTLH
 . ||| || ||||..||   .. .| .     . . .. .|  | . ||  ||.. |.
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefly