Gene Y54F10BM.13 in Caenorhabditis elegans

Synonym: CELE_Y54F10BM.13, Y54F10BM.13

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP221_AA protein Get Run
CeleP221_AA_80-222 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP19_pd Subfamily DSP19 72-220 4.9e-66 215.8 In-house 1-150 (152) alignment
Range on Protein: 72-220
Range on HMM: 1-150/152.0
GFIVDLEPDLVVGEALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGI
||..||..|| |||. |.|..||||||||  ||...|||||.||.||.||.|||.|.||.|.|||||||....|......||...|...|.|..|||||.
gfveDlkedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGv

SRSATFVVAYLMKNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
||||..|.|||||. ..|..||....||.| .|.||.||..||||||| |
SRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

subfamily_DSP1_pd Subfamily DSP1 86-219 9.3e-45 146.6 In-house 21-155 (163) alignment
Range on Protein: 86-219
Range on HMM: 21-155/163.0
ALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKN
 |. | .||. ||..| ||.. .||.|.|| . ..|.|.. ||| .. . | |.  |  .||.| ||||.|....| |.|||.||||||.|...|||||.
ildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmkt

LKISCREAMDKCRETRSI-RPNTGFAQQLKEYEAI
 ..|  ||.| ... ||| .||.|| .||..||  
krvsleeafdfvkqrRsiisPnagFvlqLlnyekk

subfamily_DSP12_pd Subfamily DSP12 85-222 6.5e-39 127.8 In-house 4-145 (155) alignment
Range on Protein: 85-222
Range on HMM: 4-145/155.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTG-IPNHFPKK--FEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAY
. || |..|.   ... . |.. ||||.. | .  .|.| .||   ....|.||| ||. |.........||.. ...|| |..||.||.|||.|.|.||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMKNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILVS
|||. |.|. .|... .| . .|.||.|| .||| .|.. ..
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck

PTPc_motif_SM00404 86-218 8.3e-39 127.7 In-house 5-139 (140) alignment
Range on Protein: 86-218
Range on HMM: 5-139/140.0
ALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPN-HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMK
 ||.| .||.. | ....|.. .|||..||.. ...    ..|..|||.. |  .. . .|...| .||.......| |..|| ||.|||||...||||.
ilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr

NLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEA
  ..| .||..  .| |. |.||..| .|| ||| 
yrqlslaeayefvkerRpiispnlnfvrqLieyek

0044763 (Phosphotyrosine protein) phosphatases II 75-222 1.3e-38 127.8 In-house 19-172 (178) alignment
Range on Protein: 75-222
Range on HMM: 19-172/178.0
VDLEPDLVVgealPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKK---------FEYLQIDILDLPETRIIDYFERVFEFIDKVR-QNEGIVF
  . .. ..    |.|. ||.  |.||. | . .||||||. . ....|.|          ..||.| | | ... ....|....|||.... ...| |.
dyinaseil....pglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvl

IHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRSIRPNTGFAQQLKEYEAILVS
.||.||..||.|.|.||||| |..|  ||..  || |.| || |. .||.|.| .| .
VHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllk

subfamily_Slingshot_pd Subfamily Slingshot 90-221 2.5e-38 125.1 In-house 26-158 (169) alignment
Range on Protein: 90-221
Range on HMM: 26-158/169.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKIS
. .||.  |..|  |.......|.||   | |.||.|||||.| . | .|| ...|... ..||.|.....  |..||  |.||||. |.|| ||. ..|
vylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeygls

CREAMDKCRETRS-IRPNTGFAQQLKEYEAILV
  ||..  .| || |.||.|| .||.||| || 
leealeyvkerrsvikPnkgflkqleeyeGile

subfamily_DSP10_pd Subfamily DSP10 85-220 3.1e-38 125.2 In-house 16-153 (159) alignment
Range on Protein: 85-220
Range on HMM: 16-153/159.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPK-KFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLM
. || |..||.  |||| .|.. .||...|| | .||.| . ...| .|.. |  .  .  |||  .|||...|...  |..||.||||||||.|.||||
qvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlm

KNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
|.|..| ..| .  .|.|. | || .|  ||.|.|  |
khlnlslndaykfvkekrpiisPnLnfmGqLlefekel

subfamily_LRR-DSP_pd Subfamily LRR-DSP 81-221 6.8e-38 124.2 In-house 118-259 (263) alignment
Range on Protein: 81-221
Range on HMM: 118-259/263.0
LVVGEALPDLLFGSQDVAADLPILENRKITHI-VNVGTGIPnHFPKKFEYLQI-DILDLPETRIIDYFERVFEFIDKVRQNEGiVFIHCNAGISRSATFV
 |  | ...| .|..| | . .||..  .||| . |.   |  ||| | || | || | .|  |  .||..  ||.. |.. | |..|| ||.|||.| |
svPdeiidklflGgldsannksilkdlgvthillavadfeP.lfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlv

VAYLMKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAILV
..||||. ..  .||.|   . |. |.||.|| .||| ||. |.
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf

subfamily_DSP14_pd Subfamily DSP14 91-219 2.1e-36 119.3 In-house 14-143 (157) alignment
Range on Protein: 91-219
Range on HMM: 14-143/157.0
LFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISC
|| |  .| .   |...|||.|.|| . .||.  |..|.... . | ||... ..|..| . |..|....| . .|| ||.||||....|||||  |.| 
LflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsL

REAMDKCRETRS-IRPNTGFAQQLKEYEAI
|||    ...|. ||||.|| .|| .||  
reayklvksaRpiirPNvGFwkqlidyEkk

DSPc Dual specificity phosphatase, catalytic domain 92-218 9.9e-36 117.5 Pfam-A 3-132 (133) alignment
Range on Protein: 92-218
Range on HMM: 3-132/133.0
FGSQDVAAdLPILENRKITHIVNVGTGIPN-HF--PKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
.||.  |  |..||. .||...|| . .|| ..  ....|||.| . |  || | ...|.. |||.|..|... |..||.||||||||...|||||  ..
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl

SCREAMDKCRETRS-IRPNTGFAQQLKEYEA
| .||..  .| || |.||.|| .|| ||| 
slneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 92-218 9.9e-36 117.5 In-house 3-132 (133) alignment
Range on Protein: 92-218
Range on HMM: 3-132/133.0
FGSQDVAAdLPILENRKITHIVNVGTGIPN-HF--PKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
.||.  |  |..||. .||...|| . .|| ..  ....|||.| . |  || | ...|.. |||.|..|... |..||.||||||||...|||||  ..
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl

SCREAMDKCRETRS-IRPNTGFAQQLKEYEA
| .||..  .| || |.||.|| .|| ||| 
slneAyefvkerrskispnagflrqLleyer

subfamily_DSP15_pd Subfamily DSP15 85-218 1e-34 113.8 In-house 4-137 (151) alignment
Range on Protein: 85-218
Range on HMM: 4-137/151.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTgIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMK
. ||.|  |   .. |   |....||||..|    .... |..||. | . | |.. .  .|.   ||| | | .|. |..|| ||.|||.| |||||| 
kvlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

NLKISCREAMDKCRETRSI-RPNTGFAQQLKEYEA
 .... |.|..  ...||.  ||.|| .|||||| 
vtelnwrdalevikaaRsvanPnfGfkrqlkeyek

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 90-217 1.1e-34 113.1 In-house 10-149 (154) alignment
Range on Protein: 90-217
Range on HMM: 10-149/154.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKK---------FEYLQIDILDLPETRIIDYFERVFEFIDKVR--QNEGIVFIHCNAGISRSATFV
|  .|.| | .   |....|..|.|||.||.| |...         .|||.... | ..  ||. ....|||||.     ... |..|...|.||||...
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

VAYLMKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYE
..|||..||||  .|.   ...|  |.||.|| .||. .|
isylmdklkislslalellkdsryiikPnqGflkqleife

0048076 (Phosphotyrosine protein) phosphatases II 85-220 2e-34 113.7 In-house 6-142 (145) alignment
Range on Protein: 85-220
Range on HMM: 6-142/145.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMK
| ||.| .||. .| ||. |.. .||...|. . ....... ..||.... | ..  .........|||.......| |..||.||..|..|.|.||||.
eilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylml

NLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
 |..|  ||... |. |. . || |. ..|.|.| .|
llgvsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_DSP6_pd Subfamily DSP6 85-220 3.6e-34 111.6 In-house 16-154 (158) alignment
Range on Protein: 85-220
Range on HMM: 16-154/158.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPK--KFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYL
| || | .||.. |..| .|.. || ...|| . .|| | .  ...|||| | |  .. .  .|   .||||. |...  |..|| |||||| | ..|||
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
||.|..|  .| |  .. .| | ||  | .||...|  |
mkklalslndaydlvkkrksnisPnfnfmgqlldfersl

0048179 (Phosphotyrosine protein) phosphatases II 85-220 3.4e-33 109.7 In-house 6-144 (144) alignment
Range on Protein: 85-220
Range on HMM: 6-144/144.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKF--EYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYL
| ||.| .||. .| ||. | . .||...|. .. ...|....  .||.... | .   .........|||.......| |..||.||..|..|.|.|||
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
|| |..|  ||..  |. |. . || |. ..|.||| .|
mkklglsleealalvrsrrpgavpnpgqlrfLleyekll

subfamily_DSP3_pd Subfamily DSP3 83-220 3.7e-33 108.5 In-house 11-157 (162) alignment
Range on Protein: 83-220
Range on HMM: 11-157/162.0
VGEALPDLLFGSQDVAADLPILENRKITHIVNVGTGI-------PNHFP-KKFEYLQIDILDLPETRIIDYFERVFEFIDK-VRQNEGIVFIHCNAGISR
| |  |.|  | ..|| |   |..  |||..|   |        ....   ...|| ... | ||. .  |||....|||. . |.|| |..||..|.||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SATFVVAYLMKNLKISCREAMDKCRETRSIRPNTGFAQQLKEYEAIL
||| |.||||   |..  ||. . |. |.|.||.|| .||.|..  |
satlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeel

0041856 (Phosphotyrosine protein) phosphatases II 74-221 1.5e-32 108.0 In-house 10-173 (182) alignment
Range on Protein: 74-221
Range on HMM: 10-173/182.0
IVDLEPDLVVGEALPDLLFGSQDV--------------AADLPILENRKITHIVNVGtgIPNHFPKKF-----EYLQIDILDLPETRiidyFERVFEFID
|.  .....  . .. |. ||.                |..|. | ...||.|||.    ....|...     .||.. . | . .     .. ...||.
ilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfie

KVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS---IRPNTGFAQQLKEYEAILV
.|....| |..||.||..|..|.|.||||| |..| .||..  |. |.   |.|| .|  ||...| .|.
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_MKPLT_pd Subfamily MKPLT 90-220 6.9e-32 104.2 In-house 29-160 (164) alignment
Range on Protein: 90-220
Range on HMM: 29-160/164.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKIS
|  |  . | .  .|.. |||||||| ..  . ||| .||||... | .........||. .|. .  .. | |..||. | |||..  ||.|.|  .  
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

CREAMDKCRETRSI-RPNTGFAQQLKEYEAIL
 .|| .  .| ||| .|| || .|| ..| ..
lkeayeylkerrsivapnrGflkqlakfeeli

subfamily_MKPLV_pd Subfamily MKPLV 90-220 6.9e-32 104.2 In-house 29-160 (164) alignment
Range on Protein: 90-220
Range on HMM: 29-160/164.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKIS
|  |  . | .  .|.. |||||||| ..  . ||| .||||... | .........||. .|. .  .. | |..||. | |||..  ||.|.|  .  
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

CREAMDKCRETRSI-RPNTGFAQQLKEYEAIL
 .|| .  .| ||| .|| || .|| ..| ..
lkeayeylkerrsivapnrGflkqlakfeeli

0049772 (Phosphotyrosine protein) phosphatases II 82-220 2.7e-31 104.9 In-house 155-273 (314) alignment
Range on Protein: 82-220
Range on HMM: 155-273/314.0
VvgealpdllfgSQDVAADLPILEnrkithivnvgTGI--PNHFPKK-FEYLQIDILDlPETRIIDYFERVFEFIDKVrQNEGIVFIHCNAGISRSATF-
            .. .||||. |.           . .  |..|..  ..||.|.. | ... ....|....|||... ...| |..||.||..|..|| 
g...........neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfv

VVAYLMKNLKISCREAMDKCRETRSIRPNTGFAQQLKEYEAIL
|.||||| |..| .||..  |..|.|.|| || .||..|| ||
vaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefil

0045098 (Phosphotyrosine protein) phosphatases II 77-222 1e-30 102.5 In-house 16-273 (278) alignment
Range on Protein: 77-222
Range on HMM: 16-273/278.0
LEPDLVVGEALPDLLFGSQD-----------------------------------------VAADLPILENRKITHIVNVG-------------------
| .   ..| .| |. |..|                                         ||...  | . .||.||..                    
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

---------------------------------TGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ--------------NEGIVFIHCNA
                                 ....... . . || ..  . |.. |...| ...|||.....              ..| |..||.|
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GISRSATFVVAYLMKNL---KISCREAMDKCRETRS--IRPNTGFAQQLKEYEAILVS
|..|..|.|.||||. |   ...  || .. |. |   . .| .. ..| |... |..
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_STYX_pd Subfamily STYX 85-221 1e-30 100.0 In-house 14-158 (166) alignment
Range on Protein: 85-221
Range on HMM: 14-158/166.0
EALPDLLFGSQDVA--ADLPILENRKITHIVNVGTG-----IPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATF
| || | .|    |  . |..|... ||||| .        |   ||..| || .|. | .   || |. .| ||||.  |. | |..| ||||||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

VVAYLMKNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILV
|.||.|.   .  |||.   .| |  | || ||..|||||||| .
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyl

subfamily_DSP8_pd Subfamily DSP8 85-220 3.7e-30 98.6 In-house 17-154 (159) alignment
Range on Protein: 85-220
Range on HMM: 17-154/159.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIP-NHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLM
. |. | .||| .. .  .|..  |....|. .  |  .. |. ..|.. . |  . .....|.. .|||||.....| |..|. |||||||| ..||.|
rilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayim

KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
|.|..|  ||    .| | .| ||  | .|| |||  |
ktlemsldeayrfvkekrptispnlnflgqLleyekel

0043147 (Phosphotyrosine protein) phosphatases II 87-220 9e-30 99.0 In-house 23-160 (172) alignment
Range on Protein: 87-220
Range on HMM: 23-160/172.0
LPDLLFGSQDVAADLPILENRKITHIVNVGTG---IPNHFPKKFEYLQIDILDLPETrIIDYFERVFEFIDK--VRQNEGIVFIHCNAGISRSATFVVAY
.. .  .. ..| ..  | ...||||||. .     .. ..  ..|| . . | . . .........||||.  .....| | .|| ||..|..|.|.||
iatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

LMKnLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
||. |..|  ||..  || |. . .| .. ..|...| .|
lml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

PTEN_1 95-221 1.4e-29 98.3 In-house 54-192 (196) alignment
Range on Protein: 95-221
Range on HMM: 54-192/196.0
QDVAADLPILENRKITHIVNVGTGIPN---------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ--NEGIVFIHCNAGISRSATFVVAYLM
 ||||||  |. ..||..||.  . ..         .| ...|||...| | .   .   |. . .||. ...  |...| .|| ||..||.| | ||||
kdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLm

KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILV
.  | . .||..  || |  ..||... ..|.||.| | 
ykgkltadeAlelvrekRppgapnspsqerlleyfaell

0040439 (Phosphotyrosine protein) phosphatases II 94-220 3.7e-29 97.5 In-house 64-245 (249) alignment
Range on Protein: 94-220
Range on HMM: 64-245/249.0
SQDVAADLPILENRKITHIVNVGTGIPN-------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVF
.. |....  | . .||.||.. .  ..                                            .......|.| ..|.|.. . ..|| ..
petvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedll

EFIDKVRQ------NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
.||..||.      ..| |..||.||..|..||..||||     |.|...  ||... |. |  . .| .. ..| |... |
dfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0046846 (Phosphotyrosine protein) phosphatases II 84-220 4.8e-27 90.2 In-house 13-172 (176) alignment
Range on Protein: 84-220
Range on HMM: 13-172/176.0
GEALPDLLFGSQD----------VAADLPILENRKITHIVNVGTGI-------PN----HFPKKFEYLQIDILDLPETRIiDYFERVFEFIDKVRQNEGI
 . ...|..||            .|..|  | . .||..||. . .       ||        ...||.... |     . .......|||...... | 
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggp

VFIHCNAGISRSATFVVAYLMKN-LKISCREAMDKCRETR--SIRPNTGFAQQLKEYEAIL
| .|| |||.|..|.|.|||..    .|  ||... || |   . .. .. ..|.|.|  |
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll

0049260 (Phosphotyrosine protein) phosphatases II 88-219 6.4e-27 89.5 In-house 13-148 (152) alignment
Range on Protein: 88-219
Range on HMM: 13-148/152.0
PDLLFGSQDVAADLPILENRKITHIVNVGTGIPNH---FPKKFEYLQIDILDLPETRIIDYFERVFEFIDK-VRQNEGIVFIHCNAGISRSATFVVAYLM
. .  |....| ..  | . .||.||.. .  ...   ... ..||.. . | .   ...... ...||.|  ....| |..|| ||..|..|.|.||||
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

KnLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAI
. |..|  ||..  || |. . || |. ..|.|.| .
l.lgvsleeavalvrekRpgavpnpgqlrflyefekl

0051082 (Phosphotyrosine protein) phosphatases II 87-216 4.2e-26 86.8 In-house 12-149 (151) alignment
Range on Protein: 87-216
Range on HMM: 12-149/151.0
LPDLLFGSQDVAADLPILENRKITHIVNVGTGI-----PNHFPK-KFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN-EGIVFIHCNAGISRSATFVV
 . |. ...  |..|. |.. .|..|||. .       |. .|.  .|.|.| ||| |.. . ..|. | ||....... .| |..||.||..|..|.|.
tgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlva

AYLMKnLKISCREAMDKCRETR--SIRPNTGFAQQLKEY
.|||. |..|  ||..  |..|  ...||..|  ||...
lylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal

0037934 (Phosphotyrosine protein) phosphatases II 85-219 5.1e-26 87.1 In-house 43-240 (243) alignment
Range on Protein: 85-219
Range on HMM: 43-240/243.0
EalPDLLFGSQ--------DVAADLPILENRKITHIVNVGTGI---------------------------------------------PNHFPKKFEYLQ
   | |  ...        |.|...  | . .||.||.. . .                                             ....   . |..
t..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IDILD----LPETRIIDYFERVFEFIDK-----VRQNEGIVFIHCNAGISRSATFVVAYLMKNL-KISCREAMDKCRETRS--IRPNTGFAQQLKEYEAI
. . |       . ..|... | |||..     .. ..| | .|| ||..|..|...||||. | ...  ||... || |.  . .. .. ..| |... 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle





subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 90-217 7.3e-25 81.2 In-house 15-144 (148) alignment
Range on Protein: 90-217
Range on HMM: 15-144/148.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKK-FEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
|  ||.  ||||  |..  .|.|||     .| . ..  |||.. . | |.  .  .|| . .|..|.... . | .|.. |.|||.  ....|..  ..
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SCREAMDKCRE-TRSIRPNTGFAQQLKEYE
| .||..  .. .| ..|| || .|| |.|
slkealalvkskrryvdpnlgfLkqLaele

0036282 (Phosphotyrosine protein) phosphatases II 88-219 9.3e-25 82.7 In-house 17-168 (174) alignment
Range on Protein: 88-219
Range on HMM: 17-168/174.0
PDLLFGSQDVAaDLPILENRKITHIVNVGTGIPNH---------------FPKKFEYLQIDILDLPETRIIDyFERVFEFIDKVRQN--EGIVFIHCNAG
| |. |.   | ... | . .||..|.. . ....                .  ..||.. . |  .  .   ......|.......  .| | .||.||
prliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaG

ISRSATFVVAYLMKNLKI-SCREAMDKCRETR----SIRPNTGFAQQLKEYEAI
..|..|.|.||||. ... | ..|.|  || |     . .. .. ..| ..| .
vgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl

0045450 (Phosphotyrosine protein) phosphatases II 104-220 1e-24 83.3 In-house 127-303 (307) alignment
Range on Protein: 104-220
Range on HMM: 127-303/307.0
LENRKITHIVNVGTGIPNHF----------------------------PKKFEYLQIDILDL-----------------PETRIIDYFERVFEFIDKVRQ
| . ..|.||.. . ... .                             ... .... . ||                 |.. . ..|| ...||..||.
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

------NEGIVFIHCNAGISRSATFVVAYLMKNLK--------ISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
      ..| | .||.||..|..||..||||. .         .. .||... || |  . .| .. ..| |... |
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0040438 (Phosphotyrosine protein) phosphatases II 104-221 2.4e-23 78.3 In-house 106-276 (317) alignment
Range on Protein: 104-221
Range on HMM: 106-276/317.0
LENRKITHIVNVGTGIPNH---------------------------FPKKFEYLQIDILDL----------------PETRIIDYFERVFEFIDKVRQN-
. . ..|.||.. .  ..                              . ...... . ||                |.  . .... ...|...||.. 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---EGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAILV
   .| | .||.||..|..||..||||     |. ...  ||... || |. . .. .. ..| .... ..
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0042113 (Phosphotyrosine protein) phosphatases II 89-220 3.2e-23 77.8 In-house 53-242 (245) alignment
Range on Protein: 89-220
Range on HMM: 53-242/245.0
DLLFGSQDVAADLP----ILENRKITHIVNVGTGIPNHFPK----------------------------------------------KFEYLQIDILDLP
 .. ...  . ...     | . .||.||.. .  .....|                                               . |..... | .
kfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhg

ETRIIDYFERVFEFIDKVRQ--NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
.. .........||..|...  ..| |..||.||..|..||..||||     |.|..|  ||... |. |  .... .. ..| |... |
vpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0036941 (Phosphotyrosine protein) phosphatases II 106-221 6e-23 77.0 In-house 100-277 (297) alignment
Range on Protein: 106-221
Range on HMM: 100-277/297.0
NRKITHIVNVGTGIPNHFPKKFEYLQ-----------------------------------------------IDILDLPETRIIDYFERVFEFIDKVRQ
. ..|.||.. . ... ..| ..|                                                 . ... |.  . .... ...||..||.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------NEGIVFIHCNAGISRSATFVVAYLM--------KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILV
      ..| | .||.||..||.||..|.||        |. ...  ||. | || |  . .. .. ..| |... |.
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_STYXL1_pd Subfamily STYXL1 85-220 1.2e-22 73.9 In-house 13-153 (157) alignment
Range on Protein: 85-220
Range on HMM: 13-153/157.0
EALPDLLF-GSQDVAADLPILENRKITHIVNVGTG---IPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVA
| ||. |. |    | .  | .. |.   ||| .    . .  ..  . |.|.. | .|. ... .... .||.| .... .|..  | ||||||. ..|
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviia

YLMKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
||| . ||. ..|... .. .. ..|| .| .||.|.|  |
ylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql

0039614 (Phosphotyrosine protein) phosphatases II 104-222 3.5e-21 71.4 In-house 121-290 (297) alignment
Range on Protein: 104-222
Range on HMM: 121-290/297.0
LENRKITHIVNVGTGIPNHFpKKFEYL-------------------------------------------QIDILDLPETRIIDYFERVFEFIDKVRQ--
. . ..|.||.. . ...   | ..|                                             ... |     ..... ...|.......  
vweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILVS
 ..| | .||.||..|..||..||||     |. ...  ||... || |  .... .. ..| .... |..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_PTPMT1_pd Subfamily PTPMT1 89-220 3.8e-19 63.8 In-house 39-168 (171) alignment
Range on Protein: 89-220
Range on HMM: 39-168/171.0
DLLFGSQDVAADLPILENRKITHIVNVGTGIPNHfpkKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
. |. ...|.| ... |. ......|      ..     |.||. . |  |.  ..  |.  |||.||...   |..||.|| .|||| | .||||. |.
keLiekenvkavvslneeyelkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkekl

SCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
|  ||..  .. |. || ..   ..|.|||  |
speeAlkalkkkRkiirlakkqwkalqeyeekl

0051429 (Phosphotyrosine protein) phosphatases II 85-218 7.1e-19 64.0 In-house 18-222 (272) alignment
Range on Protein: 85-218
Range on HMM: 18-222/272.0
EALPDLLFGSQDV----AADLPILENRKITHIVNVGTGIPNHFPK------KFEYLQIDILDLPETRIIDYF----------------------------
. .|..|. |.      |||.. |.. .|..||.. .     . |       ..||...|||  ...|  ..                            
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------ERVFEFIDKVRQnEGIVFIHCNAGISRSATFVVAYLMKnLKIS--------------CREAMDKCRETR-SIRPNTGFAQ
                    | . |... ... .| | .||.||..|..|.|...|.  | .|               .||... |. |  .... .. .
earevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLKEYEA
.| |...
flyeall

0043336 (Phosphotyrosine protein) phosphatases II 104-218 1.6e-18 62.6 In-house 108-274 (278) alignment
Range on Protein: 104-218
Range on HMM: 108-274/278.0
LENRKITHIVNVGTGIPN------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ---
. . ..|.||.. .   .                                            ..... ...  |. |.  . . .. ...|. .||.   
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

-NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEA
 ..| | .||.||..|..||...||.     |.....  ||... || | .. ..  . ..| |...
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0038934 (Phosphotyrosine protein) phosphatases II 105-216 1.8e-18 62.3 In-house 53-172 (194) alignment
Range on Protein: 105-216
Range on HMM: 53-172/194.0
ENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRI--IDYFERVFEFIDKV-----RQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKC
 |.|.......    .   |..|| . |..|.||      .  .| ...|.| |     ....|.| .|| ||..|..|.|.|||.. |..| .||..  
lnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialf

RETR-SIRPNTGFAQQLKEY
|| | .. || .. ..| ..
rekRpgaipnqdyleallkr

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 90-216 1.9e-18 60.0 In-house 6-137 (145) alignment
Range on Protein: 90-216
Range on HMM: 6-137/145.0
LLFGSQDVAADLPILENRKITHIVNVGTGI----PNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKN
|. ||   | |.|.|..  |. |||. .|      .   ...| | |   ||    . ..|. | .|||| ...   ||.|| ||.||| |  ||.||| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LKISCREAMDKCRETRS-IRPNTGFAQQLKEY
 ...  ||  . |  |    ||  | ..| . 
cnmtlseaarqvrsnrllaypnvtflknllnl

0047943 (Phosphotyrosine protein) phosphatases II 107-202 4.5e-17 57.8 In-house 100-252 (273) alignment
Range on Protein: 107-202
Range on HMM: 100-252/273.0
RKITHIVNVGTGIPN----------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ--
 ....|| . . . .                                              ........ ..  .. |.  . ...| ..|||..||.  
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

----NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETRS
    ..| | .||.||..|..||....|.     |. ...  ||. . |. | 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRp

0051299 (Phosphotyrosine protein) phosphatases II 105-202 7.7e-17 57.1 In-house 160-266 (288) alignment
Range on Protein: 105-202
Range on HMM: 160-266/288.0
ENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN----EGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMD
.. .....  . .....   ..... ..  .. |.  . |..| ...|. .||.     .| | .||.||..|..||....|.     |. ...  ||. 
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavk

KCRETRS
. || | 
rlreqRp

0050432 (Phosphotyrosine protein) phosphatases II 119-203 1.2e-15 53.1 In-house 143-280 (308) alignment
Range on Protein: 119-203
Range on HMM: 143-280/308.0
IPN----------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN--EGIVFIHCNAG
. |                                                .. ... ..  .. |.  . ...| ...|...||.   .| . .||.||
vengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaG

ISRSATFVVAYLM-----KNLKISCREAMDKCRETRSI
..|..||....|.     |. ...  ||. | || |  
vGRtGtfialdllleqlekeggvdvfeavkklReqRpg

subfamily_MSG5_pd Subfamily MSG5 139-220 6.8e-15 48.6 In-house 78-160 (165) alignment
Range on Protein: 139-220
Range on HMM: 78-160/165.0
ETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRE-TRSIRPNTGFAQQLKEYEAIL
...|.  . |. . |   . ..  ...||. |.||||...|||.||  ..| |.| || .  .  | |. |.  || |.|..|
dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval

0046845 (Phosphotyrosine protein) phosphatases II 123-207 2.2e-14 49.0 In-house 161-254 (284) alignment
Range on Protein: 123-207
Range on HMM: 161-254/284.0
FPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN------EGIVFIHCNAGISRSATFVVAYLMKNL--------KISCREAMDKCRETRsirpnT
  . ..  .. ... |.  . ...| ..||...||.       .| . .|| ||..|..||....|....        ...  ||. . || |      
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR.....p

PTPc_DSPc_SM00012 126-206 1.1e-10 36.9 In-house 4-88 (105) alignment
Range on Protein: 126-206
Range on HMM: 4-88/105.0
KFEYLQIDILDLPETRiidyfERVFEFIDKVRQNE------GIVFIHCNAGISRSATFVVAYLMKNLKISCR---EAMDKCRETRSIRPN
...|...    .||.      . ..|....|..|.      . | .|| ||..|..|||..... .   . .   .  . ..| |. ||.
hyhytgwpdhgvPees.....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpg

0048567 (Phosphotyrosine protein) phosphatases II 138-201 1.2e-10 36.0 In-house 52-118 (157) alignment
Range on Protein: 138-201
Range on HMM: 52-118/157.0
PETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGI---SRSATFVVAYLMKNLKISCREAMDKCRETR
. ....... .. .|.. .. ... . .|| ||    .|.||.. .||.. |... .||..  |  |
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr

subfamily_CDC14_pd Subfamily CDC14 149-201 2.4e-09 31.5 In-house 252-304 (328) alignment
Range on Protein: 149-201
Range on HMM: 252-304/328.0
VFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETR
| .|.. . . || . .|| ||. |  |.. .||||. ...  ||.   | .|
vkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr

Y_phosphatase Protein-tyrosine phosphatase 136-219 7.6e-09 30.7 Pfam-A 142-229 (235) alignment
Range on Protein: 136-219
Range on HMM: 142-229/235.0
DLPETRIIDYFERVFEFIDKVRQNE----GIVFIHCNAGISRSATFVVAYLMKNLKIS--CREAMDKCRETRSIRPntGFAQQLKEYEAI
. |.  . .  . ....|.||....    | | .|| ||..|..|||.. .. .   .  . . .. ..| |. ||  |  |.|..|...
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp..gmvqsleqYifl

Y_phosphatase Protein-tyrosine phosphatase 136-219 7.6e-09 30.7 In-house 142-229 (235) alignment
Range on Protein: 136-219
Range on HMM: 142-229/235.0
DLPETRIIDYFERVFEFIDKVRQNE----GIVFIHCNAGISRSATFVVAYLMKNLKIS--CREAMDKCRETRSIRPntGFAQQLKEYEAI
. |.  . .  . ....|.||....    | | .|| ||..|..|||.. .. .   .  . . .. ..| |. ||  |  |.|..|...
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp..gmvqsleqYifl

subfamily_DSP11_pd Subfamily DSP11 138-202 1.7e-08 28.5 In-house 93-158 (178) alignment
Range on Protein: 138-202
Range on HMM: 93-158/178.0
PETRIIDY-FERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS
|.  ...   |.| ||..|  .|. .. .||  |. |.  ..  ||..   .. ..|...  |.| 
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG

subfamily_DSP23_pd Subfamily DSP23 130-202 2.3e-08 28.8 In-house 57-126 (148) alignment
Range on Protein: 130-202
Range on HMM: 57-126/148.0
LQIDILDLPETRIIDYFERVfefIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS
|.||    |    .. | ||   ...  ...  | .||  |  |. |..  ||.|. |..  ||. . |. | 
lriddyhppaleqvvefvrv...veeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp

subfamily_RNGTT_pd Subfamily RNGTT 137-202 9.3e-08 26.0 In-house 91-155 (189) alignment
Range on Protein: 137-202
Range on HMM: 91-155/189.0
LPETRIIDYFERVFEFIDKvRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS
 ||.  .. | .. |   | .. | .. .||  |  |.  ..|.||... ..| ..|..  ...| 
aPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp

DSPc_SM00195 127-202 2.2e-07 25.8 In-house 158-242 (263) alignment
Range on Protein: 127-202
Range on HMM: 158-242/263.0
FEYLQIDILDLPETRIIDYFERVFEFIDKVRQN----EGIVFIHCNAGISRSATFVVAYLM-KNL----KISCREAMDKCRETRS
..  |. . . |.  . |  . |.|.. .|..     .| . .|| ||..|..|||.. .. ..|    |... | . . |. | 
rkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRp

PTPc_SM00194 127-202 2.2e-07 25.8 In-house 158-242 (263) alignment
Range on Protein: 127-202
Range on HMM: 158-242/263.0
FEYLQIDILDLPETRIIDYFERVFEFIDKVRQN----EGIVFIHCNAGISRSATFVVAYLM-KNL----KISCREAMDKCRETRS
..  |. . . |.  . |  . |.|.. .|..     .| . .|| ||..|..|||.. .. ..|    |... | . . |. | 
rkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRp

subfamily_PTEN_pd Subfamily PTEN 147-202 2.2e-07 26.0 In-house 103-157 (184) alignment
Range on Protein: 147-202
Range on HMM: 103-157/184.0
ERVFEFIDKvrQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCR-EAMDKCRETRS
| . .....  ... .| .||.||  |. . .||||.|.|...   ||..   |.|.
ediekwlee..dkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt

subfamily_VSP_pd Subfamily VSP 120-193 2.7e-07 24.7 In-house 89-162 (212) alignment
Range on Protein: 120-193
Range on HMM: 89-162/212.0
PNHFPKKFEYLQIDILDLPETR-IIDYFERVFEFIDKVRQNegIVFIHCNAGISRSATFVVAYLMKNLKIS-CREA
...| .. . ..||  ..|. . .. . ..| |...|  .|  ...|||  |  |. | | |.|..   ..  .|.
ekyfnnrvkriliddhnvpkleellvftkevkewlekdlkn..vlaihckGGkgrtGtivcalllaseifetakes

subfamily_PTPDC1_pd Subfamily PTPDC1 159-205 4.1e-07 24.6 In-house 113-161 (182) alignment
Range on Protein: 159-205
Range on HMM: 113-161/182.0
NEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS--IRP
.|| | .|| ||  |    . .||. . ...  .|... |. |.  |..
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqt

subfamily_Laforin_pd Subfamily Laforin 130-191 6e-07 22.5 In-house 80-141 (183) alignment
Range on Protein: 130-191
Range on HMM: 80-141/183.0
LQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCR
. . . ||     .. . .   ..  . ..  ||..|||||. ||.. |. .|.  |. | .
iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwsla

subfamily_Ptp69D_pd Subfamily Ptp69D 140-218 1.9e-06 22.2 In-house 195-277 (307) alignment
Range on Protein: 140-218
Range on HMM: 195-277/307.0
TRIIDYFERVFEFIDKV----RQNEGIVFIHCNAGISRSATFVVAYLMKNlKISCREAMDKCRETRSIRPN-TGFAQQLKEYEA
. . .  . ....|..|    ..|.. . .||.|| .||..||   .. . ..   . .| .  .. .| . . . |.|. |. 
skvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllq.qlkaedkvdifetvkdLrsqRnllvqsleqYvf

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 151-205 3.9e-06 21.1 In-house 200-257 (307) alignment
Range on Protein: 151-205
Range on HMM: 200-257/307.0
EFIDKVRQNEGIVFIHCNAGISRSATFVV-AYLMKNL--KISCREAMDKCRETRSIRP
.... || ..  | .|| ||. || | |  ....  .   | |..  .  .| || |.
nlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrh

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 149-181 5.1e-06 20.8 In-house 180-212 (290) alignment
Range on Protein: 149-181
Range on HMM: 180-212/290.0
VFEFIDKVRQNEGIVFIHCNAGISRSATFVVAY
. . |.||....  | .||  ||||||..    
llsliqkvkasktpvivHcvdGiSrsAalaaii

subfamily_PTPN6_pd Subfamily PTPN6 141-187 6.2e-06 20.4 In-house 207-255 (306) alignment
Range on Protein: 141-187
Range on HMM: 207-255/306.0
RIIDYFERVFEFIDKVR-QNEGIVFIHCNAGISRSATFVVAY-LMKNLK
 ..|..| | .  .... ...| . .||.||| |  ||.|   |.|...
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillklie

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 147-206 7e-06 19.9 In-house 203-264 (290) alignment
Range on Protein: 147-206
Range on HMM: 203-264/290.0
ERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCRE--AMDKCRETRSIRPN
  ..  .  .|.  | | .|| ||| |. |||      .. .  .|   .| .|  |  | |
lallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrln

subfamily_PTPRD_pd Subfamily PTPRD 138-183 9e-06 19.6 In-house 188-237 (564) alignment
Range on Protein: 138-183
Range on HMM: 188-237/564.0
PETRIIDYFERVFEFIDKVR----QNEGIVFIHCNAGISRSATFVVAYLM
|.. . .. . . ..|.|||    ...| . .||.||. |. ||.|   |
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividam