Gene mkpB-2 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP011_AA protein Get Run
DdisP011_AA_207-352 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 205-355 1.4e-67 220.9 In-house 12-163 (163) alignment 
Range on Protein: 205-355
Range on HMM: 12-163/163.0
SQLY-PSEIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTT
..|| |.|.|.||||||....|.|...| .|.||...|...|||.|...|..|....|.|.|||.|...||.||.||...||..|.|||||..|||||.|
lklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

VVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTLEWEKQ
..||||||........||.|.||.||.|.||.|||.||..|...|.||.||.
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllleleka
subfamily_DSP19_pd Subfamily DSP19 212-348 3e-44 145.0 In-house 14-150 (152) alignment 
Range on Protein: 212-348
Range on HMM: 14-150/152.0
IIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMK
 ... ||||  . | ....| . ||||..|.| ....|.|. ..|   .. | |.... .... ...||.. ... |.||.||  |.|||..||.|||||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

EDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
. ......|.. ....| ||.|| ||.||||.|...|
keelsleealelvrearpcikPneGFikqLkeyeael
subfamily_LRR-DSP_pd Subfamily LRR-DSP 208-349 1.5e-42 139.5 In-house 119-259 (263) alignment 
Range on Protein: 208-349
Range on HMM: 119-259/263.0
YPSEIIKDfLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRA-NLDDRPKANIYEHFEPVIQFINDCKKQGGrVLIHCAMGISRSTTVVL
 |.|||.. |.||| . | |.  | .| .||..   .... ..|.|.||.   ...| ..|.|. ||| .  ||.. .|.|| ||.||  |.|||.|.|.
vPdeiidk.lflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvi

AYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLT
.|||| ..... .|. . ..||. |.|| ||..||| |...| 
sylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_Slingshot_pd Subfamily Slingshot 206-358 3.2e-42 137.8 In-house 15-167 (169) alignment 
Range on Protein: 206-358
Range on HMM: 15-167/169.0
QLYPSEIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVV
||  .  | |..|||   || | ..| . ......|.. |.|. .|. ..|.. .. | ..........   .||. .||.| .||.|| ||.|||...|
qldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastv

LAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTLEWEKQEKL
.|| ||| .... .|... |..||.|.|| ||.|||. |.  |. . ....||
iayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrhnkl
subfamily_DSP14_pd Subfamily DSP14 213-349 8.5e-42 136.8 In-house 10-145 (157) alignment 
Range on Protein: 213-349
Range on HMM: 10-145/157.0
IKDFLYLGgAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKE
|.. |.|. .  | ....| . |||. .|.. || .   .  .. .  ..|.|.|....||..|.. |.. ||.||..|.||..|.||| ...|||||| 
itpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmky

DHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLT
 ...  .|..  |..|. |.|| || ||| || ..|.
eklsLreayklvksaRpiirPNvGFwkqlidyEkklk
subfamily_DSP6_pd Subfamily DSP6 207-350 8.6e-41 133.1 In-house 12-156 (158) alignment 
Range on Protein: 207-350
Range on HMM: 12-156/158.0
LYPSEIIKdFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLY--KYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTV
 .| ||.. .|||| |..| |.. | .||| ...|.. .|.... .    ||..  ..|. ..|. ..|   |.||.. ...   ||.||  ||||| ||
efpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

VLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTL
.||||||. ...  ||. . |...| | ||| |..||.|....|.|
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_MKPLT_pd Subfamily MKPLT 206-346 1.1e-40 132.8 In-house 18-158 (164) alignment 
Range on Protein: 206-346
Range on HMM: 18-158/164.0
QLYPSEIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVV
. ||| ...| |||| |..| |.. | .||||| ||.. |  | .|.  .| . ...| .. .. ...| . .|. |  . |||||.|| .| |||..| 
kiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

LAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQ
.|.|.|    |. .|. . |..||...|| ||.|||  ...
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 206-346 1.1e-40 132.8 In-house 18-158 (164) alignment 
Range on Protein: 206-346
Range on HMM: 18-158/164.0
QLYPSEIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVV
. ||| ...| |||| |..| |.. | .||||| ||.. |  | .|.  .| . ...| .. .. ...| . .|. |  . |||||.|| .| |||..| 
kiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

LAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQ
.|.|.|    |. .|. . |..||...|| ||.|||  ...
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
PTPc_motif_SM00404 209-346 1.1e-40 133.7 In-house 2-139 (140) alignment 
Range on Protein: 209-346
Range on HMM: 2-139/140.0
PSEIIKDfLYLGGAENAGNRQQLINLKITHLVNMAGELDD-VYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLA
||.| .. ||||....| |...| .|.||| .|.. | .       ... . .|||  |... .... |..||....|.||.||.||..|.||| |...|
psrilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQ
|||.........|. | |..|..|.||..||.|| .|..
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0044763 (Phosphotyrosine protein) phosphatases II 204-349 5.1e-40 132.3 In-house 18-171 (178) alignment 
Range on Protein: 204-349
Range on HMM: 18-171/178.0
GSQLYPSEIIkDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHL---------YKYYRANLDDRPKANIYEHFEPVIQFINDCK-KQGGRVLIH
. ....|||. ..||||.. .| ....| .|.|||.||...||   ....         ..|.. ...| .  ...|||. ...||...  ..||.||.|
sdyinaseil.pglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRScINPNFGFVKQLKDYQQHLT
| .|..||.|.|.|||||. .... .|. . ...|. |.||.|...||......| 
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP10_pd Subfamily DSP10 211-349 3.5e-39 128.2 In-house 15-154 (159) alignment 
Range on Protein: 211-349
Range on HMM: 15-154/159.0
EIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPH-LYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYL
  .  ||.|| ...| . . | .|.||...|.. ..   . .   || | .. |  | |. ..||  ..||.. .|.| |||.||  |||||.|||.|||
sqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYl

MKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLT
||. ... .||. | |.||. | ||..|. ||... ..|.
mkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_DSP15_pd Subfamily DSP15 211-355 1e-38 126.8 In-house 4-146 (151) alignment 
Range on Protein: 211-355
Range on HMM: 4-146/151.0
EIIKDfLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHlYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLM
..... ||||. ... ....| . .|||....  .   . ..  .|   ...| |.|.. ..|.  ..|| .|. ... ||.||..|.|||.|.| ||||
kvlpg.lylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTLEWEKQ
   .. . ||... |..||. |||||| .|||.|... . |..||
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkq
DSPc Dual specificity phosphatase, catalytic domain 217-346 3.9e-38 125.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 217-346
Range on HMM: 1-132/133.0
LYLGGAENAGnRQQLINLKITHLVNMAGELDD---VYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKED
||||....|   ..| .|.||. .|.. | .      .  ..| |  ..|  ...| ...| ...||......|..||.||..||||| |...|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQ
......|. | |..||.|.||.||..|| .|..
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 217-346 3.9e-38 125.3 In-house 1-132 (133) alignment 
Range on Protein: 217-346
Range on HMM: 1-132/133.0
LYLGGAENAGnRQQLINLKITHLVNMAGELDD---VYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKED
||||....|   ..| .|.||. .|.. | .      .  ..| |  ..|  ...| ...| ...||......|..||.||..||||| |...|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQ
......|. | |..||.|.||.||..|| .|..
nlslneAyefvkerrskispnagflrqLleyer
0048076 (Phosphotyrosine protein) phosphatases II 208-348 5.2e-38 125.3 In-house 3-142 (145) alignment 
Range on Protein: 208-348
Range on HMM: 3-142/145.0
YPSEIIKDfLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLA
.||||. . ||||.  .| ....| .|.||...|.. ||...... ..|.. ...|..  ...|... ...||... |.||.||.|| .|..|..|.|.|
wpseilpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
|||.. .... .|. . ...|....||.|....|......|
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 207-346 1.7e-36 119.0 In-house 5-145 (148) alignment 
Range on Protein: 207-346
Range on HMM: 5-145/148.0
LYPSEIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHL-YKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVV
 .|||| . ||.||  . | . ..| .| .|..||.. | | .. .   .|.  .||| || ..   ||..|.|..  |..|.|||.|. ||.|||. ..
tfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

LAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQ
|..|.. ....  .|. . |.||  ..|| ||.||| ...|
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0048179 (Phosphotyrosine protein) phosphatases II 209-348 3.1e-36 119.6 In-house 4-144 (144) alignment 
Range on Protein: 209-348
Range on HMM: 4-144/144.0
PSEIIkDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLY--KYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVL
||||. . ||||.   | . ..| .|.||...|.. | .  ..  .  .|.. ...|..  ...|... ...||... ..||.||.|| .|..|..|.|.
pseil.pglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
|||||. .... .|. . ...|....||.|....|..|...|
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_DSP3_pd Subfamily DSP3 215-349 6.4e-36 117.4 In-house 16-158 (162) alignment 
Range on Protein: 215-349
Range on HMM: 16-158/162.0
DFLYLGGAENAGNRQQLINLKITHLVNMAG-ELDDV--YPHLY-----KYYRANLDDRPKANIYEHFEPVIQFINDCKKQ-GGRVLIHCAMGISRSTTVV
. ||.|... | ....| .| |||..| |  .. .|   .. |     ||.  ..|| |.... ..||.. .||..  .|  |.||.||..|.|||.|.|
pklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlv

LAYLMKEDHMTYSDAFTFCKQKRsCINPNFGFVKQLKDYQQHLT
|||||   .||  .| .  ..|| .| || ||.|||......|.
layLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
subfamily_DSP12_pd Subfamily DSP12 213-349 7e-36 118.0 In-house 5-144 (155) alignment 
Range on Protein: 213-349
Range on HMM: 5-144/155.0
IKDFLYLGGAENAGNRQQLINLKITHLVNMAGE-LDDVYPHLYK--YYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYL
|.. |||||.|.. . ..| .|||||.. .. | |..  ..  |  .   ...|.|...| .|.. ...||... ...| ||.||..|.||| |.|.|||
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLT
||....  ..|. . |.|.. |.|| ||..||| ...  .
mkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
0049772 (Phosphotyrosine protein) phosphatases II 232-378 4.4e-34 114.0 In-house 167-303 (314) alignment 
Range on Protein: 232-378
Range on HMM: 167-303/314.0
InlkithlvnmaGEL---DDVYPHLYKYYRANLDDrPKANIYEHFEPVIQFINDCkKQGGRVLIHCAMGISRSTT-VVLAYLMKEDHMTYSDAFTFCKQK
            .||   ...  . .||.| ...| . |.. |.|. ...||... ..||.||.||..|..|..| ||.|||||  .... .|. . ..|
k...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlk

RScINPNFGFVKQLKDYQQHLTLEWEKQEKLKKQQQQTLNINNNNTGIPLS
|. ||||.||..||..|...|    |....|||  . . ..  .. ... |
Rp.inpnpgfieqleqyefilealleylkflkkfyeyleenlldglqllis
0043147 (Phosphotyrosine protein) phosphatases II 214-350 1.3e-32 108.3 In-house 23-162 (172) alignment 
Range on Protein: 214-350
Range on HMM: 23-162/172.0
KDFLYLGGAENAGNRQQLINLKITHLVNMAGE---LDDVYPHLYKYYRANLDDRPKAnIYEHFEPVIQFIND--CKKQGGRVLIHCAMGISRSTTVVLAY
 .......   | ....| .|.|||.||. ..    ...... ..|.. . .| .   . |... ...||..  ....||.||.|| .|..|. |.|.||
iatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

LMKeDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTL
||.  .... .|. . ..||... .|... ..|......| |
lml.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
subfamily_STYXL1_pd Subfamily STYXL1 207-348 3.6e-31 101.5 In-house 9-153 (157) alignment 
Range on Protein: 207-348
Range on HMM: 9-153/157.0
LYPSEIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPH---LYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTT
 ||.|.. ..||||  ..| |..   .||.   ||.. . |...       |  . ...| ..|.. |... ..|||.. ||.|  ||.    |||||..
tyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

VVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
|..|||| . ..|. .|... |. .. ..|| .||.||......|
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
subfamily_DSP8_pd Subfamily DSP8 212-349 4.2e-31 101.7 In-house 17-155 (159) alignment 
Range on Protein: 212-349
Range on HMM: 17-155/159.0
IIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDD-VYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLM
 | ..||||  ... ... | .| |.. .|.  .  .    .  |. |  . |. . .. . |.  ..||. .|.. ||||.|.  |||||.||..||.|
rilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayim

KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLT
|. .|.. .|..| |.||  |.||. |..|| .|...|.
ktlemsldeayrfvkekrptispnlnflgqLleyekelk
0041856 (Phosphotyrosine protein) phosphatases II 210-348 4.3e-31 103.3 In-house 19-172 (182) alignment 
Range on Protein: 210-348
Range on HMM: 19-172/182.0
SEIIKDFLYLGGAEN--------------AGNRQQLINLKITHLVNMAGEL---DDVYPHLYKYYRANLDDRPKANiyehFEPVIQFINDCKKQGGRVLI
.  | . ||||.  .              | . ..| .|.||..||...||   .... . ..|.. . .| .  .    .. ...||......||.||.
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlV

HCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRS--CINPNFGFVKQLKDYQQHL
|| .|..|. |.|.|||||. .... .|. . ...|.  .|.||..|. ||. .. .|
HCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
PTEN_1 209-348 4.6e-31 103.1 In-house 36-191 (196) alignment 
Range on Protein: 209-348
Range on HMM: 36-191/196.0
PSE----IIKDFLYLGGAENA-GNRQQLINLKITHLVNMAGELDD---------VYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKK--QGGRVLI
||.     | ..||.| .. .  ....|   .||..||.. | ..          . . ..|..   .| .. .. |.|. . .||. ...  .|. ||.
psrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlV

HCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
||. |..|| ||| ||||.   .|. .|. . ..||....|| .. ..|. |.. |
HCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0049260 (Phosphotyrosine protein) phosphatases II 213-348 7.8e-30 99.0 In-house 11-149 (152) alignment 
Range on Protein: 213-348
Range on HMM: 11-149/152.0
IKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVY---PHLYKYYRANLDDRPKANIYEHFEPVIQFIND-CKKQGGRVLIHCAMGISRSTTVVLAY
.  ....|.   | . ..| .|.||..|..  .|.. .   .....|.. . .| .  .. .... ...||.  ....||.||.||  |..|. |.|.||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMKeDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
||.  .... .|. . ..||....||.|. ..|......|
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0045098 (Phosphotyrosine protein) phosphatases II 205-351 7.2e-29 96.5 In-house 18-274 (278) alignment 
Range on Protein: 205-351
Range on HMM: 18-274/278.0
SQLYPSEiIKDFLYLGGAE-----------------------------------------NAGNRQQLINLKITHLVNMAGELDD---------------
.. .||| | ..||||...                                          | . ..| .|.||..|........               
llgipse.itpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsl

-------------------------------------VYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKK--------------QGGRVLIHCAMG
                                      . . ..|.     . |  .|. .|  ...||... |              .||.||.|| .|
tygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

ISRSTTVVLAYLMKED---HMTYSDAFTFCKQKRSC-INPNFGFVKQLKDYQQHLTLE
..|. |.|.||||.|    .... .|... ...| . . .|... ..| .....| | 
vgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_STYX_pd Subfamily STYX 229-347 1.2e-28 93.3 In-house 33-156 (166) alignment 
Range on Protein: 229-347
Range on HMM: 33-156/166.0
QQLINLKITHLVNMAGE-----LDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTF
..| .  |||.| .  .     .   .|. ..|   .. | .  ||  ..  | .||.|. ..||.||.|   |||||...|.||.|.   . | .||..
evlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafay

CKQKRSCINPNFGFVKQLKDYQQH
 ...| ||||| |||.|||.|.  
vqerrfcinpnegfvsqlkeyeai
0046846 (Phosphotyrosine protein) phosphatases II 211-348 1.8e-28 94.9 In-house 13-172 (176) alignment 
Range on Protein: 211-348
Range on HMM: 13-172/176.0
EIIKDFLYLGGAE----------NAGNRQQLINLKITHLVNMAGEL-----------DDVYPHLYKYYRANLDDRPKANIyEHFEPVIQFINDCKKQGGR
  | . |.||..            | . ..| .|.||..||.  |            .... . ..|.. . .|    .. |... ...||... |.||.
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggp

VLIHCAMGISRSTTVVLAYLMKE-DHMTYSDAFTFCKQKRS-CINPNFGFVKQLKDYQQHL
||.|| .||.|. |.|.|||..   .... .|. . ...|. .. ........|... ..|
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0040439 (Phosphotyrosine protein) phosphatases II 227-348 7.1e-27 90.0 In-house 70-245 (249) alignment 
Range on Protein: 227-348
Range on HMM: 70-245/249.0
NRQQLINLKITHLVNMAGELDD-------------------------------------------VYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDC
....| .|.||..|..  .                                               ..  ....  .  | |  .. ..||....||. .
fwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieav

KK------QGGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
.|      .||.||.|| .|..|. |...||||     || .... .|. . ...|... .|... ..| .. ..|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0036282 (Phosphotyrosine protein) phosphatases II 212-347 1.1e-26 89.0 In-house 14-168 (174) alignment 
Range on Protein: 212-347
Range on HMM: 14-168/174.0
IIKDFLYLGGAENAgNRQQLINLKITHLVNMAGEL---------------DDVYPHLYKYYRANLDDRPKANIYEhFEPVIQFINDCKKQ--GGRVLIHC
.| . |..|..  | . ..| .|.||..|..  |                .| ... ..|.. . .|.   .. . .. ...|.... ..  || ||.||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

AMGISRSTTVVLAYLMKEDHM-TYSDAFTFCKQKR---SCINPNFGFVKQLKDYQQH
 .|..|. |.|.||||.  .. .. ||. . ...|   ... ..... ..| .... 
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0037934 (Phosphotyrosine protein) phosphatases II 211-348 3.2e-26 87.8 In-house 41-241 (243) alignment 
Range on Protein: 211-348
Range on HMM: 41-241/243.0
EIIkDFLYLGGA--------ENAGNRQQLINLKITHLVNMAGEL---------------------------------------------DDVYPHLYKYY
..  . |.....          | . . | .|.||..|..  .                                              ||.. . ..|.
yvt.prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

RANLDD----RPKANIYEHFEPVIQFIND-----CKKQGGRVLIHCAMGISRSTTVVLAYLMKED-HMTYSDAFTFCKQKRSC-INPNFGFVKQLKDYQQ
. .  |       ........ |..||..     . ..||.||.|| .|..|. |...||||..  .... .|. . ...|.. . ..... ..| .. .
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

HL
.|
el
0045450 (Phosphotyrosine protein) phosphatases II 229-348 6.1e-26 87.3 In-house 125-303 (307) alignment 
Range on Protein: 229-348
Range on HMM: 125-303/307.0
QQLINLKITHLVNMAGELDD-------VY---------------------PHLYKYYRANLDDR-----------------PKANIYEHFEPVIQFINDC
..| ....|..|.. .. ..        .                      . |.... .. |                  |  .. ..||....||. .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KK------QGGRVLIHCAMGISRSTTVVLAYLMKEDH--------MTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
.|      .||.||.|| .|..|. |...||||.. .        ... .|. . ...|... .|... ..| .. ..|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 215-347 1.2e-25 83.7 In-house 8-151 (154) alignment 
Range on Protein: 215-347
Range on HMM: 8-151/154.0
DFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHL---------YKYYRANLDDRPKANIYEHFEPVIQFINDCK--KQGGRVLIHCAMGISRSTT
 |||..  . | |. .| . .|....|..   ......          ..| . .| | .. .| |... . .||.|     . ..||.|.  |.|||..
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

VVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQH
....|||.. ....| |. . |. |  |.|| ||.|||. ....
llisylmdklkislslalellkdsryiikPnqGflkqleifeke
0042113 (Phosphotyrosine protein) phosphatases II 213-347 1.8e-24 81.9 In-house 50-241 (245) alignment 
Range on Protein: 213-347
Range on HMM: 50-241/245.0
IKDFLYLGGAENAGNRQ----QLINLKITHLVNMAGEL----------------------------------------------DDVYPHLYKYYRANLD
|.. ......  ... .    .| .|.||..|..  |                                               || . . . |.. . .
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DRPKANIYEHFEPVIQFINDCKK--QGGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQH
| . ... |... ...|.... .  ..|.||.|| .|..|. |...||||     ||  ..  .|. . ...|... ..... ..| .. ..
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 212-344 1.6e-23 78.4 In-house 10-149 (151) alignment 
Range on Protein: 212-344
Range on HMM: 10-149/151.0
IIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLY------KYYRANLDDRPKANIYEHFEPVIQFINDCKKQ-GGRVLIHCAMGISRSTTV
 . ..||..|.  | . ..| .|.|.. ||. .|    | . |      ....  ..| |  .. ..|. |..|.. . .. .| ||.|| .|..|. |.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

VLAYLMKeDHMTYSDAFTFCKQKRS-CINPNFGFVKQLKDY
|..|||.  .... .|. . ..||  ...|| .|..||...
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0040438 (Phosphotyrosine protein) phosphatases II 229-351 3.4e-23 77.8 In-house 104-278 (317) alignment 
Range on Protein: 229-351
Range on HMM: 104-278/317.0
QQLINLKITHLVNMAGELDD---------------------------VYPHLYKYYRANLDDR----------------PKANIYEHFEPVIQFINDCKK
. . ....|..|..  . ..                           .. . .....  . |                 |  .. ........|.. ...
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

Q----GGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTLE
.    || ||.|| .|..|. |...||||     || .... .|. . ...|... ..... ..| |. ... . 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0039614 (Phosphotyrosine protein) phosphatases II 229-349 6.1e-21 70.6 In-house 119-289 (297) alignment 
Range on Protein: 229-349
Range on HMM: 119-289/297.0
QQLINLKITHLVNMAGELDDVYpHLYKYY-------------------------------------------RANLDDRPKANIYEHFEPVIQFINDCKK
. . ....|..|..  . ..   . ..|.                                             .  |    .. |..  ........ .
rmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---QGGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLT
   .||.||.|| .|..|. |...||||     || .... .|. . ...|... ..... ..| |. ..| 
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0036941 (Phosphotyrosine protein) phosphatases II 231-350 1e-20 69.7 In-house 98-278 (297) alignment 
Range on Protein: 231-350
Range on HMM: 98-278/297.0
LINLKITHLVNMAGELDDVYPHLYKYYRAN-----------------------------------------------LDDRPKANIYEHFEPVIQFINDC
. ....|..|..  . ..  .  ..|.  .                                                 . |  .. |.......||. .
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

KK------QGGRVLIHCAMGISRSTTVVLAYLM--------KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTL
.|      .||.||.|| .|..|| |...|.||        ||  ... .|. . ...| .. ..... ..| .. ..| .
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 217-348 7.6e-20 64.5 In-house 6-141 (145) alignment 
Range on Protein: 217-348
Range on HMM: 6-141/145.0
LYLGGAENAGNRQQLINLKITHLVNMAGE----LDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKE
|| | | .| .   | .| |. .||||       .... . ..      .|    .. .||. | .||.  |..|  |..||  |.||| || .|.||| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

DHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
  || |.|    . .|    ||  |.|.| . .. |
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0051429 (Phosphotyrosine protein) phosphatases II 208-350 9.3e-20 66.8 In-house 15-226 (272) alignment 
Range on Protein: 208-350
Range on HMM: 15-226/272.0
YPSEIIKDFLYLGGAE---NAGNRQQLINLKITHLVNMAGEL------DDVYPHLYKYYRANLDDRPKANIYEHF-------------------------
| .......||..|.    .| . ..| .|.|.. |.. .|        | |..  .|.. .. |.    |  ..                         
ygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlll

-----------------------EPVIQFINDCKKqGGRVLIHCAMGISRSTTVVLAYLMKeDHMT--------------YSDAFTFCKQKRSCINPNFG
                       |....... . . ||.||.||. |..|. |||...|.    ..              . .|    ...| ..... .
sagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee

FVKQLKDYQQHLTL
....| .. ..|  
qylflyeallellr
0038934 (Phosphotyrosine protein) phosphatases II 246-349 1.4e-18 62.7 In-house 72-177 (194) alignment 
Range on Protein: 246-349
Range on HMM: 72-177/194.0
LDDVYPHLYKYYRANLDDR---PKANIYEHFEPVIQFINdCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLK
 .... . ..|..    |.   |  .|. .|  ......  ...|| |..|| .|..|. |.| |||..  .|.. .|  . ..||  . || .....| 
peefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleall

DYQQHLT
 . ..| 
krykelr
subfamily_PTPMT1_pd Subfamily PTPMT1 257-348 4.2e-17 57.1 In-house 77-168 (171) alignment 
Range on Protein: 257-348
Range on HMM: 77-168/171.0
YRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHL
.. .  |  .|   |. |  ..||.. ...| || .||  | .||.|.| .||||.....  .| .. |.||. |. .   .|.|. |...|
lqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0043336 (Phosphotyrosine protein) phosphatases II 229-346 1.1e-16 56.5 In-house 106-274 (278) alignment 
Range on Protein: 229-346
Range on HMM: 106-274/278.0
QQLINLKITHLVNMAGELDD---------------------------------------------VYPHLYKYYRANLDDRPKA-NIYEHFEPVIQFIND
. . .|..|..|.. .. ..                                              . . . |.  .  |     ..  ... . .... 
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

CKKQGGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQ
.....| ||.||  |..|. |....||.     || .... .|. . ...| .. ... . ..| .. .
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_MSG5_pd Subfamily MSG5 240-348 3.3e-15 49.6 In-house 52-160 (165) alignment 
Range on Protein: 240-348
Range on HMM: 52-160/165.0
VNMAGELDDVY---PHlYKYYRANLDDrpKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFG
.|.| |..|.    |   |||  . .   ...|   .  . . |   . .. ..|.||  |.|||.....||.||   ..  ||.   | .   |.|..|
invakeindlellvpa.vkyyhieweh..dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsig

FVKQLKDYQQHL
.. || ...  |
lifqlmeweval
0047943 (Phosphotyrosine protein) phosphatases II 233-341 4.8e-15 51.2 In-house 99-264 (273) alignment 
Range on Protein: 233-341
Range on HMM: 99-264/273.0
NLKITHLVNMAGELDDVYPHLYKYYRANLDD----------------------------------------------RPKANIYEHFEPVIQFINDCKK-
. .....| .  . ..  .  ..|.  . ..                                               |  .. ...|....||....| 
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

-----QGGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNFGFVKQL
     ..| |..||  |..|. |.....|.     ||  ... .|. . ...| .. ... . ..|
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 262-335 9.8e-13 43.7 In-house 190-272 (288) alignment 
Range on Protein: 262-335
Range on HMM: 190-272/288.0
DDRPKANIYEHFEPVIQFINDCKKQ----GGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNF
 . |  .. ...|....|.....|.    || |..||  |..|. |.....|.     || .... .|. . ...| .. ...
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 233-335 1.1e-12 43.3 In-house 130-285 (308) alignment 
Range on Protein: 233-335
Range on HMM: 130-285/308.0
NLKITHLVNMAGELDDVYPHLYKYYRANLD----------------------------------------------DRPKANIYEHFEPVIQFINDCKKQ
. .... | .  . ..  .  ..|.  .|.                                              . |  .. ...|....|.. ..|.
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

--GGRVLIHCAMGISRSTTVVLAYLM-----KEDHMTYSDAFTFCKQKRSCINPNF
  || ...||  |..|. |.....|.     || .... .|. . ...| .  ...
lpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 263-333 3.2e-10 35.3 In-house 174-258 (284) alignment 
Range on Protein: 263-333
Range on HMM: 174-258/284.0
DRPKANIYEHFEPVIQFINDCKKQ------GGRVLIHCAMGISRSTTVVLAYLMKED--------HMTYSDAFTFCKQKRSCINP
. |  .. ...|....|.......      || ...||  |..|. |.....|..|         .... .|. . ...| .   
swpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq
0048567 (Phosphotyrosine protein) phosphatases II 265-330 9.4e-10 33.1 In-house 52-120 (157) alignment 
Range on Protein: 265-330
Range on HMM: 52-120/157.0
PKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGI---SRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSC
. | .|. .  . .|.......|... .|| .|    .|. |.. .||..  ..| ..|. . .. |  
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpg
PTPc_DSPc_SM00012 260-346 7e-09 31.2 In-house 9-87 (105) alignment 
Range on Protein: 260-346
Range on HMM: 9-87/105.0
NLDDRpkaNIYEHFEPVIQFINDCKKQG------GRVLIHCAMGISRSTTVVLAYLMKEDHMTYSdaftfckqkrsCINPNFGFVKQLKDYQQ
.  |    .. |. ..........||.       . |..||  |..|. |.|..... ..... .                | .||.|.....
gwpdh...gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket...........kevdifqivkelrkqRp
subfamily_DSP23_pd Subfamily DSP23 231-329 4.7e-08 27.8 In-house 27-126 (148) alignment 
Range on Protein: 231-329
Range on HMM: 27-126/148.0
LINLKITHLVNMAGEL---DDVYPHLyKYYRANLDDRPkANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQK
|..| . .|| .. |     .  | |  ..| ..||       |  .  .. ... ....  | .||..|  |. |..  ||.|| ... ..| .  ...
lldlgvrylvslteegrphveatpnl.tlvrlriddyh.ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RS
| 
rp
Rhodanese Rhodanese-like domain 30-65 5.2e-08 25.4 Pfam-A 7-49 (113) alignment 
Range on Protein: 30-65
Range on HMM: 7-49/113.0
QDI-GSSKIIIDLRTKEQYEKNHIRTSVNIPP------PPSTT
. . ... ...| |..|.|.| ||. .||.|.       ....
ellekekvvllDvRspeeyakghIpgAvnvpldslyprrdlff
subfamily_PTPDC1_pd Subfamily PTPDC1 280-352 1.5e-07 26.0 In-house 108-179 (182) alignment 
Range on Protein: 280-352
Range on HMM: 108-179/182.0
INDCKKQGgRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTLEW
.. . ..| .| .||  |  |   .. .||.  ...| ..| .. ..||.      . |. .|.....|.  .
vafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfliplr
subfamily_DSP11_pd Subfamily DSP11 265-341 3.3e-07 24.4 In-house 93-170 (178) alignment 
Range on Protein: 265-341
Range on HMM: 93-170/178.0
PKANIYEHFEPVI-QFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQL
|| .....|. .. .|....|...  . .||. |. |.  ..  ||.. . .  .||    .. |        ..|.|
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdL
subfamily_CDC14_pd Subfamily CDC14 276-328 5.5e-07 23.7 In-house 252-304 (328) alignment 
Range on Protein: 276-328
Range on HMM: 252-304/328.0
VIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKR
| .|.. ..|  | . .||  |. |  |.. .||||. ..| ..| .. .  |
vkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
subfamily_RNGTT_pd Subfamily RNGTT 234-329 1.7e-06 21.8 In-house 61-155 (189) alignment 
Range on Protein: 234-329
Range on HMM: 61-155/189.0
LKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDcKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRS
|  |.    . ||..   .  |   |   ..|.|.  ..|  ...  .. |.    . .||  |  |.  .. .||... ..  ..| .  .. | 
ltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp
Y_phosphatase Protein-tyrosine phosphatase 265-330 2e-06 22.8 Pfam-A 144-215 (235) alignment 
Range on Protein: 265-330
Range on HMM: 144-215/235.0
PKANIYEHFEPVIQFINDCKKQG----GRVLIHCAMGISRSTTVVLAYLMKEDHMT--YSDAFTFCKQKRSC
|. .. |. ......|....|.     | |..||  |..|. |.|.. .. |   .    | . ..|. |..
pdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkq
Y_phosphatase Protein-tyrosine phosphatase 265-330 2e-06 22.8 In-house 144-215 (235) alignment 
Range on Protein: 265-330
Range on HMM: 144-215/235.0
PKANIYEHFEPVIQFINDCKKQG----GRVLIHCAMGISRSTTVVLAYLMKEDHMT--YSDAFTFCKQKRSC
|. .. |. ......|....|.     | |..||  |..|. |.|.. .. |   .    | . ..|. |..
pdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkq
DSPc_SM00195 260-314 3.7e-06 21.8 In-house 164-222 (263) alignment 
Range on Protein: 260-314
Range on HMM: 164-222/263.0
NLDDRPKANIYEHFEPVIQFINDCKKQ----GGRVLIHCAMGISRSTTVVLAYLMKEDH
.  . |. .. .. ..|..... .||.     | ...||  |..|. |.|.. .. .  
qyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskl
PTPc_SM00194 260-314 3.7e-06 21.8 In-house 164-222 (263) alignment 
Range on Protein: 260-314
Range on HMM: 164-222/263.0
NLDDRPKANIYEHFEPVIQFINDCKKQ----GGRVLIHCAMGISRSTTVVLAYLMKEDH
.  . |. .. .. ..|..... .||.     | ...||  |..|. |.|.. .. .  
qyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskl
subfamily_PRL_pd Subfamily PRL 284-346 4.5e-06 20.8 In-house 87-147 (151) alignment 
Range on Protein: 284-346
Range on HMM: 87-147/151.0
KKQGGRVLIHCAMGISRSTTVVlAYLMKEDHMTYSDAFTFCKQKRS-CINPNfgFVKQLKDYQQ
.. .  | .||  |. |.  .| |  . |. |.| ||  | ..||  .|| .   .| |..|..
eepkstvavhcvaGlGraPvlv.alalieaGmkyedavefirekrrgainsk..qlkflekyka
PTPlike_phytase Inositol hexakisphosphate 254-310 8e-06 20.5 Pfam-A 93-147 (149) alignment 
Range on Protein: 254-310
Range on HMM: 93-147/149.0
YKYYRANLDDRpKANIYEHFEPVIQFINDCkKQGGRVLIHCAMGISRSTTVVLAYLM
.||.|  . |  .|   |... ....|..  ..   ....| .|  |.||..  . .
vkYvRipitde.qapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 254-310 8e-06 20.5 In-house 93-147 (149) alignment 
Range on Protein: 254-310
Range on HMM: 93-147/149.0
YKYYRANLDDRpKANIYEHFEPVIQFINDCkKQGGRVLIHCAMGISRSTTVVLAYLM
.||.|  . |  .|   |... ....|..  ..   ....| .|  |.||..  . .
vkYvRipitde.qapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL