Gene Ptp69D in Drosophila melanogaster

Synonym: 69D, CG10975, CT30751, DPTP, DPTP69D, Dmel\CG10975, Dptp69D, PTP69D, PTPase, Ptp, Ptp69d, R-PTP 69D, dptp69D, dptp69d, ptp69D, ptp69d, Dmel_CG10975, Ptp69D

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Ptp69D
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP039_AA protein Get Run
DmelP039_AA_875-1158 phosphatase_domain Get Run
DmelP039_AA_1170-1452 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Ptp69D_pd Subfamily Ptp69D 871-1176 1.1e-155 512.4 In-house 2-305 (307) alignment
Range on Protein: 871-1176
Range on HMM: 2-305/307.0
GPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPME
|.|...|||.|.|.|..|||.|...|||.|..|..|..||.|. ||||.||||.||||.|.|||||..||| ...|||||.|..||||.||||.||.|.|
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

STIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPE
.||.||||||.||....||||.||.|.|..|||||||.   |..|.||||||...|.|..|||.|.|.|||.|...||.||.|...||||..|||...||
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

HPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMA
...|..|.|.|....|.|.|.||.|||||||||.|..||||||.|||..||.|.|..||.|||.|||.|||||.||.||||||||. ..|.||...|...
vargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle

SAIESL
.|||.|
daierl

subfamily_Ptp69D_pd Subfamily Ptp69D 1169-1453 1.2e-127 420.3 In-house 9-288 (307) alignment
Range on Protein: 1169-1453
Range on HMM: 9-288/307.0
MASAIESLKRKPNEGKCKlevEFEKLLATadEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENT
...|..| ||....|..|   |.||| |.  ||.||..|.|..||..|||...|...|..||.|......|.|.|||||||.||.....||.||||.|.|
leealksrkrdtdfglak...eyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

IGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWA-DDEVQYDHILVKYVHSESCPYYTRREFYVTNCK-----IDDTLKVTQFQYNGWPtvDGEVPEVC
||||||||.||.||..||.|.... .| ||..||. .|||||..||||.|..|....|..||..|...|     ..|. ||.|..|.||.  | .||||.
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPeva

RGIIELVDQAYNHYKNNknsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
||...|..|....||.|     |||..||||.|..||.||||...|.|.|..|..|||..|...|||||. |..|..||.||.||...||. 
rgllklieqvrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_PTPRD_pd Subfamily PTPRD 872-1202 2.6e-116 384.5 In-house 4-326 (564) alignment
Range on Protein: 872-1202
Range on HMM: 4-326/564.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRfSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMES
||.  .|.. ... ... |. | .||. . .. .  |..... ..|  |||| .| |||..||.|  ..| . .|||||.|. ||..||..| .|||...
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEH
||.|||||.|||. ..|||||.||| .| ||.||||||  .|...|.. |.. .| .  ||. ||....|.|     ... |...|.|.  | |  .||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..gtetygeltVtleeeeeladyeirtfklkkkk.....ssesreVrqFhFtsWPdhgvpes

PHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMAS
. .....||..... . ..|||.|||||||||||| ...|.......||. | ||..|  ||.|||..||. .||||...|.|.  ..|||.. .... .
atslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkq

AIESLKRK-PNEGKCKLEVEFEKLLaTADEIS
... |... ....  .||.||..|  ||.|| 
hlqkLaeveedtemtgleleFqrLa.takeie

0051299 (Phosphotyrosine protein) phosphatases II 872-1155 1.3e-97 322.0 In-house 4-284 (288) alignment
Range on Protein: 872-1155
Range on HMM: 4-284/288.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMES
.|.  .|..........  .|.|.|.|.|.. . |.|.. . |.||  ||||.|| .||..|||| |..|  ..|||||... ||.  .|||..|||...
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnVGEEEDRRQITQYHYLTWKDFMAPEH
|..|||||.|||. ..|||||.|.|... |||.|||.   .....||| |..  | . .||. ||| |....  .. ..  |..|..||..| |. .|..
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldl.ldgdgesrtvthfhytnwpdhgvpds

PHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|  ...|.|....... . ||..||||||||||||..||| |..|||.|  |.....|. ||.||...||.. ||.|.|.|||.
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0040438 (Phosphotyrosine protein) phosphatases II 877-1191 7.2e-97 319.7 In-house 4-310 (317) alignment
Range on Protein: 877-1191
Range on HMM: 4-310/317.0
DLENAYKNRHKDTDYGFLREYEMLPNRFSDrTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDF
||..|.. ..|   ...|.|.|.|.. . | |.. . |.||  |||||||  ||..|||| ...|   .|||||..| |.....|||..|||...|..||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGII
|||.|||....|||||.|||... |||.|||.   .|...||. |.. .| . .... ||| |...     .... |..|..||..| |. .|..|  ..
wrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.....gdsesrtvthfhytgWpdhgvppspdlll

KFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL
.|......... . ||.|||||||||||||..|.. ...|||.|  |.....|. ||.||.  ||.. ||.|||.|||.  ....|....   ....  |
dfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl

KRKPNEGKCKLEVEF
....  .. ||... 
liplalddvklkeke

subfamily_PTPRB_pd Subfamily PTPRB 872-1156 1.5e-96 317.9 In-house 6-284 (293) alignment
Range on Protein: 872-1156
Range on HMM: 6-284/293.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMES
||.  ..|. .|. ..|.|..|  |||.| .  .|...| ..|..|..|||| .| .||..||||| ... ...||||||.. ||. ...|| .|||. .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTkQFGDILVKFAQERKTGDYIERTLNVSKnkanvgeEEDRRQITQYHYLTWKDFMAPEH
|.||||||.||.. .||||||.| |  | || .|||..  .. ..||| |.. .|... |.. |.|...|       |...|...|||...| |.  ||.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek.......ekeerkvrqyhftsWpdhgvPek

PHGIIKFIRQINSVY--SLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
.. ...|.|.....   . ...||.||||||||||||..||| |.|..|||| | |. .|..||..||.|||. |||||.....|| 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

0050432 (Phosphotyrosine protein) phosphatases II 870-1156 2.1e-96 318.2 In-house 23-298 (308) alignment
Range on Protein: 870-1156
Range on HMM: 23-298/308.0
AGPIHRLDLENAYKNrhKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLavinGlQTTDYINANFVIGY--KERKKFICAQG
  ... ||| .....  ..  ... .|.| |.. . ..... . |.||  ||||.|| .||..||||    . ...|||||..| ||  | ..|||..||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqg

PMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVF-DTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeeDRRQITQYHYLTWKDF
|...|..|||||.|||. ..|||||.|.|... |||.|||...  .....|.. |..  | . .||. ||| ..... .     . |..|..||..|.|.
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.....esrtvthfhytnWpdh

MAPEHPHGIIKFIRQINSVYslQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
 .|..|  ...|........  . |||.||||||||||||..||| |..|||.|  |.....|. ||.||.. ||.. ||.|||||||. 
gvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 877-1194 4.2e-96 316.7 In-house 6-318 (318) alignment
Range on Protein: 877-1194
Range on HMM: 6-318/318.0
DLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDF
|||.  .. ... .  . .|||.|    .  |. .|  . |. |||| .| |||.|||||  ..| ...||||||.. ||...|..| ||.|.  ||.||
dleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDf

WRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGII
|||.|||.  .|||||..||  |||...|||.|  .....|.. |.  .| ...||. |...|...     |||. ||. |||| .| |   ||.. ...
WrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrt.....eeeesrqvrqyhytsWpdegvpesgasll

KFIRQINSVY-SLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIES
...||....  . ..|||.|||||||||||. .|.|.|......|  | ...||  ||.||| .||  .||.|.| .||.  . |.|..  . ..| |. 
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LKR-KPNEGKCKLEVEFEKL
|.. .|. |. ....||..|
lreqdpesgttemdaefqrl

0036941 (Phosphotyrosine protein) phosphatases II 882-1168 2.6e-94 311.1 In-house 4-288 (297) alignment
Range on Protein: 882-1168
Range on HMM: 4-288/297.0
YKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLaviNGlQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
.. ....  ...|.|.| |.... . ... . |.|| .||||.|| .||.|||||   .. . .|||||..| ||.  .|||..|||...|..|||||.|
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERK--TGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFI
||. ..|||||.|.|... |||.|||... .....||. |..  . .   .||. ||| |...     .... |..|..||..| |. .||.|  ...||
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.....gngesrtvthfhytgwpdhgvpespaslldfi

RQINSVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLE---EEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDT
.....|..|  . ||.||||||||||.||..|.| ..||||   .|  |.|...|. ||.||.. ||.| ||.|||.|||.   ...|..... 
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 873-1191 1.6e-93 308.2 In-house 5-318 (319) alignment
Range on Protein: 873-1191
Range on HMM: 5-318/319.0
IHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDrTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMEST
|.  .|.. .|. .. .. .. .|...| .  .| |..... .||  ||||..|.|||.|||.|. ..| . .|||||.|. ||.||.||| .|.|.| |
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

IDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFdtKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEeedrRQITQYHYLTWKDFMAPEHP
|.|||||.||..  |.||||.| |  | |. |||||. |  ...| ..|.  .|... ||| | |.. |....|      |......|. | |   ||. 
iedfWrmvWeeessivvmltklveklkvklkkywpeenf..eeyGrlivtleeeeeledyiirklklnkkssevet....RevkhfqyteWpdhdvPeka

HGIIKFIRQIN-SVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMAS
 ........|. |.   | ||| |||||||||||| ..||  .....||  . ...||  || |||..||  .||.|.| |||.  ..|.|.| .. .  
tslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrd

AIESLKR-KPNEGKCKLEVEF
 . .|.  ... |. .|| ||
rlkqlaekvadtgetgleref

DSPc_SM00195 894-1155 1.4e-92 305.1 In-house 3-260 (263) alignment
Range on Protein: 894-1155
Range on HMM: 3-260/263.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
 .|.| | .  |...|.... |.|  |||| .|. ||.|||||  ... ...||||||.. |....||.|..|||..||..|||||.||.. .||||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTG-DYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGP
 || .| ||..||||.  ....||.| ||. .. |.  ..| |||...|..      |. |..|||.| .|.|  .|.... .....|.... .| . ||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|.||||||||||||.|..|.....||||. |.| ..|. ||.||  .||.|.||.|.|.|.|.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 894-1155 1.4e-92 305.1 In-house 3-260 (263) alignment
Range on Protein: 894-1155
Range on HMM: 3-260/263.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
 .|.| | .  |...|.... |.|  |||| .|. ||.|||||  ... ...||||||.. |....||.|..|||..||..|||||.||.. .||||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTG-DYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGP
 || .| ||..||||.  ....||.| ||. .. |.  ..| |||...|..      |. |..|||.| .|.|  .|.... .....|.... .| . ||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|.||||||||||||.|..|.....||||. |.| ..|. ||.||  .||.|.||.|.|.|.|.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0046845 (Phosphotyrosine protein) phosphatases II 892-1156 6.6e-92 303.2 In-house 1-273 (284) alignment
Range on Protein: 892-1156
Range on HMM: 1-273/284.0
GFLREYEMLPNRFSDR--TTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL-QTTDYINANFVIGY-----KERKKFICAQGPMESTIDDFWRMIWEQ
|. .|.|.|.. . ..  ... . |.||  ||||.|| .||..|||| ...|  ...|||||..| ||     . .||||..|||...|..|||||.|||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

HLEIIVMLTNLEEYNKAKCAKYWPEKvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN
. ..|||||.|.|... |||.|||..  .....||. |..  | . .||. ||| ....    | ..  |..|..||..| |. .|..|  ...|.|...
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl....gytgesrtvthfhytswpdhgvppspedlleflrlvr

SVYS--LQRGPILVHCSAGVGRTGTLVALDSLIQQLEEED---SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
....   . |||.||||||||||||..||| |..|||.|.    |.....|. || ||.. ||.| ||.|.|.|||. 
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley

0047943 (Phosphotyrosine protein) phosphatases II 885-1154 8.3e-92 302.8 In-house 6-269 (273) alignment
Range on Protein: 885-1154
Range on HMM: 6-269/273.0
RHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLavinGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQH
....  ...|.|.|.|.. . . |.. . |.||  ||||.|| .||..||||    | ...|||||..| ||.  .|||..|||...|..|||||.|||.
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

LEIIVMLTNLEEYNKAKCAKYWPEKVFD-TKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN
 ..|||||.|.| .. |||.|||... . ....|.. |..  | . .||. ||| .....      .. |..|..||..| |. .|...  ...||....
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.....tgesrtvthfhytgwpdhgvppslesllefielvr

SVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
....   . ||..||||||||||||..||| |..|||.|  |.....|. || ||   ||.. ||.|||.|||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

0039614 (Phosphotyrosine protein) phosphatases II 877-1155 2.6e-89 294.9 In-house 18-287 (297) alignment
Range on Protein: 877-1155
Range on HMM: 18-287/297.0
DLENAYKNRHKDTDYGFLREYEMLPNRFSDrtTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL-QTTDYINANFVIGYKE-RKKFICAQGPMESTID
 |. ... ....  ...|.|.|.|.. . |  .. . |.||  ||||.|| .||..|||| ...|    .|||||..| ||.   .|||..|||...|..
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMIWEQHLEIIVMLTNLEEYNKaKCAKYWPEKVFdtkQFGDILVKFAQERKTGDYIERTLNVSKnkanvGE-EedrRQITQYHYLTWKDFMAPEHPH
|||||.|||. ..|||||.|.|... |||.||||..    ..||. |.. .. . ..|. |||.|..     .. .   |..|...|. | |. .|... 
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.....nges...rtvthfqytgwpdhgvppsle

GIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
 ...|.........   . ||.|||||||||||||..|.. ...|||.|  |.....|. || ||.  ||.. ||.|||.|||.
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

subfamily_PTPRA_pd Subfamily PTPRA 862-1179 2.9e-89 294.2 In-house 6-317 (330) alignment
Range on Protein: 862-1179
Range on HMM: 6-317/330.0
SGNHKGFdagPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKK
|||.| |   |.   .||.  . |  |    |  |.. ||    . | . .. .||  |||...|  || .|| |.|..| ...||||| |. ||||..|
sgnkkyf...plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdk

FICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTkqFGDILVKFAQERKTGDYIERTLNVSkNKANVGEEEDRRQITQYHYL
|| |||| | |..|||||||||.   |||||.|.| .. |||.|||..   |  .|.| |.  .|  . ||  | . |  ....  .|.. |...|.|. 
fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt..yGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhft

TWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGN
.| |.  | .| |..|........   . ||| ||||||||||||...||....... |  | ....|  || ||  .||...|| |.|..||.   .|.
swPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd

TDICIDTMASAIESLKRK
|.. . .. . ...|. |
teldvsslekhlqklynk

0043336 (Phosphotyrosine protein) phosphatases II 873-1154 4.1e-89 294.0 In-house 2-274 (278) alignment
Range on Protein: 873-1154
Range on HMM: 2-274/278.0
IHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSdRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMEST
|.. ||..|.......  ...|.|.| |.. .   |.. . |.||  ||||.|| .||..|||| ...|   .|||||..| ||.  .|||..|||...|
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

IDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPekvFDTKQFGDILVKFAQERKTGDYIERTLNVSKnkanvGEEEDRRQITQYHYLTWKDFMAPEHP
..|||||.||.. ..|||||.|.|... |||.|||    .....||. |..  | . .||. |||.|..       .   |..|.|||| | |. .||..
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.....lgdgesrtvthyhylgwpdhgvpesl

HGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
  ...|......... . ||.|||||||||||||..||. |..||| |  |.....|..||.||   ||.. ||.|||.|||
sllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0045450 (Phosphotyrosine protein) phosphatases II 872-1154 4.9e-89 294.3 In-house 8-301 (307) alignment
Range on Protein: 872-1154
Range on HMM: 8-301/307.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFS--DRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL-QTTDYINANFV--------IGYKERK
.| .|.|. ... ...|  .|.|.|.|.|..       ... . |.||  ||||.|| .||.||||| ...|  ...|||||..|         ||.  .
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

KFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHY
|||..|||...|..|||||.|||. ..|||||.|.|... |||.|||..  .....|.. |..  | . ..|. |||.|. .    ....  |..|..||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl....dgtgesrtvthfhy

LTWKDFMAPEHPHGIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDS---VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
..| |. .|...  ...||........   . ||.|||||||||||||..|.. ...|||.|     |.....|. || ||   ||.. ||.|||.|||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

subfamily_PTPRG_pd Subfamily PTPRG 884-1168 1e-88 293.0 In-house 12-298 (563) alignment
Range on Protein: 884-1168
Range on HMM: 12-298/563.0
NRHKDTDYGFLREYEMLPNRFSDR--TTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTT-DYINANFVIGYKERKKFICAQGPMESTIDDFWRMI
. | |.| || .|.| | ..  ..  ... |. .||  |||| .| |||..||||. . | . . ||||||.. ||.  |.|| .|||...|.|||||||
slhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmi

WEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEE-EDRRQITQYHYLTWKDFMAPEHPHGIIKFI
|||. .||||.|||.| .. ||  |||.   .....| . |.  .| ..  | .||| . . | . ... .. ....|||| .| |  .|||.   ..|.
WeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifv

RQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDT
.. .     . |||.||||||||||||...||.|..|...|..| .....  .| |||||||.  |||||. |||.. . ..|..  . 
kkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 884-1155 7.1e-88 289.4 In-house 14-277 (288) alignment
Range on Protein: 884-1155
Range on HMM: 14-277/288.0
NRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQ
. ....  || .||. |..  ...... . | .|| ||||..| .||..||||   .  ...|||||... |.|..||.|..|||. .|..|||....|.
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

HLEIIVMLTNLEEYNKAKCAKYWPEKVfDTKQFGDILVKFAQERKTGDYIERTLNVSknkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN
. . |||||.| | .| || .|||..  . |..|.. |.  ......|...|.| .         ......||||.||.| |   ||  . .....||..
ktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkllle.......kkkteleitqyqylaWpdhgvPeskapllellrqvk

SVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
   . . |||.|||||||||||| .||| ||...|||| . . .||. ||.||..||| ||||.|.|..||.
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

Y_phosphatase Protein-tyrosine phosphatase 917-1154 4e-86 283.6 Pfam-A 1-234 (235) alignment
Range on Protein: 917-1154
Range on HMM: 1-234/235.0
NACKNRYPDIKAYDQTRVKLaviNGLQT-TDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQ
|  ||||.|| .||.|||||   .| .. .||||||.| |||| ||||..|||..|||.|||||.|... ..|||||.||| .. |||.||||.  ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVKFA-QER-KTGDYIERTLNVSKNKANVgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSL
.||| |.   .|  .. .|. |.|...|.|..     ..|...|.|| .|.|  .||.|......||....  . ..||..||||||||||||.|||| |
ygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

IQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
..|||.|..|.....|. ||.||. .||||.||||||.|.|
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 917-1154 4e-86 283.6 In-house 1-234 (235) alignment
Range on Protein: 917-1154
Range on HMM: 1-234/235.0
NACKNRYPDIKAYDQTRVKLaviNGLQT-TDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQ
|  ||||.|| .||.|||||   .| .. .||||||.| |||| ||||..|||..|||.|||||.|... ..|||||.||| .. |||.||||.  ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVKFA-QER-KTGDYIERTLNVSKNKANVgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSL
.||| |.   .|  .. .|. |.|...|.|..     ..|...|.|| .|.|  .||.|......||....  . ..||..||||||||||||.|||| |
ygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

IQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
..|||.|..|.....|. ||.||. .||||.||||||.|.|
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 879-1178 3.1e-82 271.2 In-house 10-304 (305) alignment
Range on Protein: 879-1178
Range on HMM: 10-304/305.0
ENAYKNRHKDTDYGFLREYEMLPNRfsDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWR
..  |. ....| |.  .|..|...  . ...    ..|. |||. .|  .|. |..|.  . |. .|||||..| |||..||.| ||||...|..||||
aayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWr

MIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKF
.|.| . . |||||.| | .| || .||||.. ..|.||.. |.  .|... ||||| |..|...     ... |...||.  .| |   |. .  ....
liveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede....dkesrtvlqyqltdWPdhGvpqfatsllsl

IRQINSVYSLQRG-PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLK
|....  .. ..| |.||||||||||||. .|.|  ...|..|..| ... .  ||..|  .||.|.|| ||. || .  | |.|.| .. .  ... ||
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk

R
.
k

0040439 (Phosphotyrosine protein) phosphatases II 910-1154 6.8e-82 270.1 In-house 4-243 (249) alignment
Range on Protein: 910-1154
Range on HMM: 4-243/249.0
KNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEk
. . |.||  ||||||| .||..|||| ...||  .|||||... ||.  ..||..|||...|..|||||.||.. ..|||||.|.|... |||.|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

vFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTL
  .....||. |.. .. . .||. ||| ....     .. . |......|. | |. .|...  ...||........   . ||.|||||||||||||.
.ggsleygdftvtllsvevkddytvrtleltnl.....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

VALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
.|.. ...|||.|  |.....|..||.||.  ||.. ||.|||.|||
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 878-1174 1.8e-81 268.9 In-house 21-308 (319) alignment
Range on Protein: 878-1174
Range on HMM: 21-308/319.0
LENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKN-SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDF
.. . |.  .|    .  |.  ....  . .... ..|..|  |||. .| |.|...|||  ..| . .||||| || ||. ..|.| ||||.. |..||
qqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladf

WRMIWEQHLEIIVMLTnleeynKAKCAKYWPEKVFDTKQFGDILVKFAQERKTgdYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGII
||||||..   ||.||      | ||..||| |.  ... ... |.  .| .   |. | ...|..    |.|.| |.|||.|.| | |   |..|  ..
Wrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsed....gkekdirkitqfhflGwpdvGvpdypsdlm

KFIRQINSVYSLQ--RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIE
....... . | .  | .|.|||||||||||. ..|| |.....||. | .||.| ||| ||| |||.| || |.| |||.   ||..|...  . . .|
rlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle





subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 880-1155 1e-80 265.9 In-house 4-274 (281) alignment
Range on Protein: 880-1155
Range on HMM: 4-274/281.0
NAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRM
.  |..... . || .||| | .   | |.. |  .||  |||| .| |||.||||..  .  ..||||||||| |||. |..| .|||. .....||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFdTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFI
.|||. ..|||.|.  | .| || .|||..   . ..||. ||. .|...  ||||.........      . |...| .|..| |  .|. .. ...| 
vweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresg......etreveqlaytaWPdhGvPattkellefr

RQINSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQLEEE-DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
...... . ..  |...||||||||||| .||| |....|.|  .... ..| .||..||..||.. || |.|.|.||
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 886-1164 5.3e-80 263.8 In-house 22-297 (298) alignment
Range on Protein: 886-1164
Range on HMM: 22-297/298.0
HKDTDYGFLREYEMLPNRFS---DRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWE
.| .  |.  |.. | .  |   . ... .  .||  ||||.|| |.|..|| |  ... . .||||| |. .||.|. || .|.|...|. |||||..|
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

QHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQI
.. . ||||||||| .| |. ||||..   ....|.| |.  .. . .|.| |.|.|||.|     ||..|.. | |. .| |  .||. . .....|..
edigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkk.....eekerevrqlhftsWpdkgvpenatsvldllrkv

NSvYSLQRG--PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDI
.  .  | |  |..|.|||||||.|| .|.||.......| .| ....|  ||..|  .||. .||.|.| | |.  . .|..|
ra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 896-1177 8.7e-80 263.2 In-house 3-275 (284) alignment
Range on Protein: 896-1177
Range on HMM: 3-275/284.0
EYEMLPNRFSDRTTKN-SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTnl
|.  ....  . |... ..|..|  |||. .| |.|...|||  . | . .||||| |. ||. ..|.| .|||.. |..||||||||..   ||.||  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

eeynKAKCAKYWPEKVFDTKQFGDILVKFAQERKTgdYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQ--RGP
    | ||..||| |.  ... ... |.  .| .   |. | ...|..    |.|.| |.|.|.|.| | |   |..|  ......... . | .  | .
....kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsed....gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhran

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLK
|.|||||||||||. ..|| |.....||. | .||.| ||| ||| |||.| || |.| |||.   ||..|...  ... .| | 
ivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

0042113 (Phosphotyrosine protein) phosphatases II 914-1154 1.2e-79 262.4 In-house 6-240 (245) alignment
Range on Protein: 914-1154
Range on HMM: 6-240/245.0
LKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDT
|.||  ||||.|| .||.||||| ...|   .|||||..| ||.  .|||..|||...|..|||||.||.....|||||..||... |||.|||.   ..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

KQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYS-LQRGPILVHCSAGVGRTGTLVALDS
...||. |..  | . .||. |||.|...      .   |....|||| | |. .|...  ...|.. ......  . ||.|||||||||||||..|.. 
ltygdftvtllseehlddytvrtlevtnl.....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

LIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...|||.|  ||....| .|| ||   ||.. ||.|||.|||
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

0045098 (Phosphotyrosine protein) phosphatases II 887-1155 1.7e-79 262.4 In-house 3-270 (278) alignment
Range on Protein: 887-1155
Range on HMM: 3-270/278.0
KDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKlavinglqttDYINANFVIGYkeRKKFICAQGPMESTIDDFWRMIWEQHLE
.. .. .| |.| |.  ..  .  .. . .|. ||||.|| .||..|||          |||||... ||  .||||..|||..||..|||||.||.. .
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

IIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEdRRQITQYHYLTWKDFMAPEHP--HGIIKFIRQINS
.|||||.|.|... |||.||||   .....||. |.. .|  ..||. |||.|     .  . |  | .|..|||.| |. .|..|    .......|..
vivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefire

VYSL-------------QRGPILVHCSAGVGRTGTLVALDSLIQQLeeEDSVSIYNTVCDLRHQRNF-LVQSLKQYIFLYRALLD
...|             . ||.||||||||||||||||.. ....|  |. |.....|. || ||..  ||.| ||.|||..||.
alkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_PTPRK_pd Subfamily PTPRK 888-1191 1.7e-78 258.6 In-house 19-312 (314) alignment
Range on Protein: 888-1191
Range on HMM: 19-312/314.0
DTDYGFLREYEMLPNRfSDrTTKNsdlKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEI
   ||| .||| |..   | ..|.   .||  |||. || |||..||.| .|.| . .|||||... .||  ..|| .|||...|. ||||......   
aegygfkeeyeslfeg.wd.aakk...denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencas

IVMLTNLEEYNKAKCAKYWPEkvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYS
|||||.| |  . || |||||   ||...||| |.. .     ... |...|.| .      |..|.. |...|.| |.  | . .|..|..|....   
ivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklar...gqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqe

LQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-KRKPNEGKCK
 . |.|.|||||| ||||| .|.|.... .|.|. | ..|.| .|| ..  .|.  .||.|.| ..|..   |.| | .  . ..  .  .  |.    .
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssq

LEVEF
|. ||
lkeef

subfamily_PTPN9_pd Subfamily PTPN9 889-1155 5.4e-75 247.2 In-house 14-288 (297) alignment
Range on Protein: 889-1155
Range on HMM: 14-288/297.0
TDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEII
   |  .||. . |.    | ..| |. |  |||| |.  ||.|||.|| ... ...|||||||| |||..| || .|||.. |..|||||.|||.  .|
gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN---SV
|| | ..|  . ||..|||..  ....|||. |.  . ... || .|.|.... |     .|. |..| . .|.| |.  |.  . ........    ..
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.....teesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

Y----------SLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
            ..  ||.||||||.|||||...||  ...|||.. | . .||  || || | .|  .|| | | |.|.
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_PTPN12_pd Subfamily PTPN12 908-1155 6.6e-75 246.7 In-house 31-275 (290) alignment
Range on Protein: 908-1155
Range on HMM: 31-275/290.0
TTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
.|.... .||  |||| ||  ||..||.|  |.. .  |||||||. | ......| ||||.  |.|||||||||...||.||. .. | .| ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

EKVFDTKQFGDILVKFAQERKTG-DYIERTLNVSKNkanvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGT
|.. .. .||.. |.  .|...  |.. |||.| ..       ...|...|.||  | |   |. .. ....|...... . .  |..||||||||||||
eegeeelefgefevtleeekavdddflirtLkveaq.......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGt

LVALDSLIQQLEEED---SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
..|.|   ..|..|    ...... | .||.||. |||. .|| ..|.|...
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

0050432 (Phosphotyrosine protein) phosphatases II 1181-1452 1.1e-74 246.8 In-house 38-300 (308) alignment
Range on Protein: 1181-1452
Range on HMM: 38-300/308.0
NEGKCKLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILtplpmRENSTYINASFIEGY--DNSETFIIAQDPLENTIGDFWRMISE
  .. .|| |||.||.. .  . ..||.. .||  |||.  |.|||..||.|      |.|.|||||.. ||  ... .||..| ||.||..|||||. |
aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

QSVTTLVMISEIGDGP-RKCPRYWAD----DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYN
| |.. ||. .. .    ||..|| .    . ..|... |.... |....||.|....||.. .....||.|.| .||  |. ||.  . ........ .
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrk

HYKNnknsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
....       .|  |||| |  |.  |.|. .|...|. |..||.. . .|||.|| | .... ||.||.||.. |  
slpg.......gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0051299 (Phosphotyrosine protein) phosphatases II 1161-1450 1.3e-74 246.6 In-house 2-285 (288) alignment
Range on Protein: 1161-1450
Range on HMM: 2-285/288.0
NTDICIDTMASAIESLKrkpNEGKCKLEVEFEKLLATADEisKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFII
.|.| .. ...... |.     |...|. |||.||.       ..|..  .||  |||.. |.|||..||.|..|.  |.|.|||||.|.||... .||.
dteisveellklvlkll...angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

AQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWA-DDEVQYDHILVKYVHSESCPYYTRREFYVTNC----KIDDTLKVTQFQYNGWPtvD
.| ||.||..|||||. || |.. ||. .. .   .||..||  .. ..|..| |.... |....|| |...|||.    . . ...||.|.| .||  |
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..d

GEVPEVCRGIIELVDQAYNHYKnnknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
  ||.  . ..... .......      . .|  |||| | .|.  |.|. .|...|. |..||.. . ..||.|| |....  ||.|...|.. |
hgvpdspellldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0037934 (Phosphotyrosine protein) phosphatases II 912-1154 5.1e-74 244.1 In-house 5-239 (243) alignment
Range on Protein: 912-1154
Range on HMM: 5-239/243.0
SDLKENACKNRYPDIKAYDQTRVKLaviNGlqtTDYINANFVIGYKerkKFICAQGPMESTIDD----FWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
. |.||  ||||.|| .||..||||   .|   .||||||.. ...   ..|. |||...|..|    ||||.||.. ..|||||.|.|... |||.|||
allpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

ekvfDTKQFGDILVKFAQERKTGDYIERTLNVSknkaNVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV--------YSLQRGPILVHCSA
    .....||. |.. .|. ..||. ||| ..    |.....  |....|||| | |. .|..|  ...|.......        .  . ||.||||||
....gevtygdftvtllseehlddytvrtllle....nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GVGRTGTLVALDSLIQQLeeedSVSIYNTVCDLRHQRNF-LVQSLKQYIFLYRALL
||||||||.|.. ....|    .|.....|..|| ||..  ||.. ||.|||.|||
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_PTPRD_pd Subfamily PTPRD 1204-1451 1.7e-73 243.2 In-house 39-281 (564) alignment
Range on Protein: 1204-1451
Range on HMM: 39-281/564.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWA
.... ....| .||| ..|..||..||.|....  |.| |||||||.||......| .| ||..|| |||||. || ..| ||.... .  . || .|| 
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

DD-EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKnnknsGCRSPLTVHCSLGTDRSSIF
.. . .|... |. ...|   .|. |.| ... | ... .|.||..  ||  |  |||  .....|...  .. .       . |..|||| |  |. .|
ekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWP..dhgvpesatslLdlirkvralne.....pdagPivVhCSaGVGRTGtf

VAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
... .... .. || |||  . ..||.||  .. .  || |.|.|| .. 
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal

DSPc_SM00195 1187-1450 2.5e-73 242.0 In-house 2-261 (263) alignment
Range on Protein: 1187-1450
Range on HMM: 2-261/263.0
LEVEFEKLLATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVM
|. |||||.. . .   ... .| ..|. |||...|.|||..||.|.. . .|.|.||||..|.|.......|..| ||..|. |||||..|. |.. ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ISEIGD-GPRKCPRYWADD---EVQYDHILVKYVHSESCP-YYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNNkns
..|  . | .|| ||| ..   . ....| || |. |...  ...|.. .|... ..| ||||.||..||    .||.  . ..||. .........   
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts...

gcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
   .|. |||| | .|. .||.. |....|. || |||... ..||.|| |.... .|| |...||..|
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 1187-1450 2.5e-73 242.0 In-house 2-261 (263) alignment
Range on Protein: 1187-1450
Range on HMM: 2-261/263.0
LEVEFEKLLATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVM
|. |||||.. . .   ... .| ..|. |||...|.|||..||.|.. . .|.|.||||..|.|.......|..| ||..|. |||||..|. |.. ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ISEIGD-GPRKCPRYWADD---EVQYDHILVKYVHSESCP-YYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNNkns
..|  . | .|| ||| ..   . ....| || |. |...  ...|.. .|... ..| ||||.||..||    .||.  . ..||. .........   
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts...

gcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
   .|. |||| | .|. .||.. |....|. || |||... ..||.|| |.... .|| |...||..|
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 915-1155 4.7e-73 240.5 In-house 7-240 (250) alignment
Range on Protein: 915-1155
Range on HMM: 7-240/250.0
KENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAkCAKYWPEKVfdTK
 .|  |||| || |.|..|| |   .| . .||||| |. ||.||| || .|||...|| |||||..|.. . |||||||.| .|  . .||| ..  ..
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..ae

QFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL-QRGPILVHCSAGVGRTGTLVALDSL
..||..|.  .. . .||. |.| .||.|     ..|.|.. |.|...| |   ||. . ..........     . .|..|.|||||||.|. .|.|..
kyGdvtvsllskeefadytkrklklskak.....kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

IQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
...|..|  | ... .  ||..|   |.||.||.|.|...| 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk

0046845 (Phosphotyrosine protein) phosphatases II 1187-1451 2.1e-72 239.2 In-house 2-274 (284) alignment
Range on Protein: 1187-1451
Range on HMM: 2-274/284.0
LEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMR-ENSTYINASFIEGY-----DNSETFIIAQDPLENTIGDFWRMISEQS
|| |||.||     .. |.||.  .||  |||.. |.|||..||.|..|. . |.|.|||||...||     ... .||..| ||.||..|||||. || 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VTTLVMISEIGDGPR-KCPRYWA--DDEVQYDHILVKYVHSESCPYYTRREFYVTNCK-IDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYK
|...||. |. .  | ||..||   .. ..|... |.... | ...||.|....||..  . ...||.|.| .||  |  ||.  . ..|..... ....
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrelle

NnknSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK---CVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|   ... .|  |||| |  |.  |.|. .| ..|. |.   .||.. . ..||.|| | .....||.|...|...| 
n...lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

subfamily_PTPN6_pd Subfamily PTPN6 883-1153 2.8e-72 238.3 In-house 18-293 (306) alignment
Range on Protein: 883-1153
Range on HMM: 18-293/306.0
KNRHKDTDYGFLREYEMLPNR-FSDR-TTKNSDLKENACKNRYPDIKAYDQTRVKLAvINGLQTTDYINANFVIG--YKERKKFICAQGPMESTIDDFWR
|.... .  ||  |.| | ..  ... . |... .||..||||  |  .|.|||.|.  .... .||||||.. .   ...|..| .|| .|.|. ||||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKqFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKF
|.|... ..|||.|.  | .| |||.|||..  ... .|.| |.  .|... ||| |.|.|||.     .... |.. |||. .| |   |..|  ...|
mvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk....kkkkeerevfqyhfksWPdhgvpkdpgavLdf

IRQINSVYSLQR----GPILVHCSAGVGRTGTLVALDSLIQQLEEED---SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
....|. ..  .    |||.||||||.|||||.. .| |....|..     . |...|  .|.||. |||  .|| |.|.|.
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 884-1191 4.6e-72 237.6 In-house 17-314 (315) alignment
Range on Protein: 884-1191
Range on HMM: 17-314/315.0
NRHKDTDYGFLREYEMLPNRFSD--RTTKNSdlkENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
...  |  || ..|| .|       ...|..   ||  |||| .| |||..||.| ...  . .||.||||. ||. ....|.||||  ....||||...
qkkastkngfkqdyesipggqlhpldvakki...enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvf

EQHLEIIVMLTNLEEYNKAKCAKYWPEKvfdTKQFGDILVKFAQERKTGDYIERTLnvsknkaNVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQ
|...  ||||||| | .| |. ||||.|      .| | |   .| .  .|  |||        |  ... |.. |.|| .| |   |..   ....||.
eedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl.......svvfgdnirevvqlhytswpdmgvpkytiplmnlirt

INSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-KRKP
..     . |.|.||||||||||||...||....|.| |. . .|| .  .|..|  .||...|| |.| |||.|   |.| |. |      .||    |
vkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapsp

NEGKCKLEVEF
. |   |. .|
dtgstllqeqf

0047943 (Phosphotyrosine protein) phosphatases II 1181-1450 8.7e-72 237.2 In-house 8-271 (273) alignment
Range on Protein: 1181-1450
Range on HMM: 8-271/273.0
NEGKCKLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILtplpMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQS
  |. .|. |||.|| . .  . ..||.. .||  |||.. |.|||..||.|      ..| |||||...||. . .||..| ||.||..|||||. || 
llgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VTTLVMISEIGDG-PRKCPRYWADD----EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHY
|...||. |. .   .||..|| ..    ...|... |...  |....|| |....||.. .....||.|.| |||  |  ||.    ..|..... ...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkal

KNNKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
......   .|  |||| |  |.  |.|. .|...|. |..||.. . ..||||| | . .. ||.||..|...|
ealpsn...gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0036941 (Phosphotyrosine protein) phosphatases II 1184-1451 1.9e-71 236.1 In-house 12-277 (297) alignment
Range on Protein: 1184-1451
Range on HMM: 12-277/297.0
KCKLEVEFEKLlaTADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILtplpMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
. .|. |||.|  .   .. |.||....||  |||.  |.|||..||.|      |.| |||||...||| . .||..| ||.||..|||||. || ||.
lalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

LVMISEIGD-GPRKCPRYWA---DDEVQYDHILVKYVHSES--CPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKN
.||..|  . |  ||..||    .....|... |.... |.  ...||.|.. ||. . .....||.|.| |||  |  |||  . ........ ...|.
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp..dhgvpespaslldfielvrkvlkl

NKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQHLR---LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
  ..   .|  |||| |  ||  |.|. ...| |.    |..|||. . .|||.|| | . .. ||.||..|.... 
lpsg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 915-1197 7.9e-71 233.7 In-house 41-317 (515) alignment
Range on Protein: 915-1197
Range on HMM: 41-317/515.0
KENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTK
. |  |||| .|  ||..|||| |||     ||.|| .. ...  | .|..||| ....|||||......   |.|.|.|.| .| ||.||||.|  |. 
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

QFGDILVKFAQERKTGDYIERTLNVSKNkanvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLI
.|| | |.       .. | |.|.| |.       .| | .||.|.  | |  .|.|   ..|.|... .  .    |...|||||||||| ....|| .
kfGsikvelvsleactggikrkltvlkg.......ddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvv

QQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKP-NEGKCKLEVEFEKLLAT
 . .. ..| ..|.|  .| .| .|||   || |.| |.|.   . || | .  ..  .. |.     .|. |.  ||. | . 
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlksl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 882-1193 9.3e-71 233.2 In-house 11-314 (315) alignment
Range on Protein: 882-1193
Range on HMM: 11-314/315.0
YKNRHKDTDYgFLREYEMLPNRFSDRTTKNsDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
. |. . |   | .|.  ||.    |..     ..|  |||| .|  .|..|||| ||.     ||||| .. .... | .|..||| ....||||||..
fvnknrhtal.fseefhdlpdPdiyrqrva.retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvl

EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLnVSKNkanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQ
...   |||.|...| .| ||..|||..  |. .|| | |.  .   ..| . | | | ..       |. |..||...  | |  ....   ..|.|..
qekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk......seesrtvtqfqftewPdkGvdkqtssllklike

INSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKP-
. .    .  ..|||||||||||| ....|. ..|.....|| ..|.|  || .| .|||. ..| |.| |.|.   . || | .  ..  .. |.    
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd

NEGKCKLEVEFEK
 .|..|.  |||.
gsgrskmtkefet

subfamily_PTPN3_pd Subfamily PTPN3 894-1154 5.1e-70 230.6 In-house 18-272 (280) alignment
Range on Protein: 894-1154
Range on HMM: 18-272/280.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAviNgLQTtDYINANFVI----GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIV
| ..|.|  .  ....... . ||. |||| || .||.|||||   .  .| ||||||.|     . .  ...| .|||...|  |||.|.|||. ..||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk..e.set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLTNLEEYNKAKCAKYWPEkVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQ
|||.| |  . || .||||   |. ..|.. ||  .|..|  |. | | .......     ..|.|.|  || | |   |.... ...|....... | .
mlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketk.....eerkilqlqylaWpdhgvPddsadflefvervrklrsgk

RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
. |..||||||.|||| |..|.  .. .|....| . . |  .| ||  |||. .|| |.  |.|
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

0043336 (Phosphotyrosine protein) phosphatases II 1182-1450 8.3e-70 230.7 In-house 17-276 (278) alignment
Range on Protein: 1182-1450
Range on HMM: 17-276/278.0
EGKCKLEVEFEKLLATADeisKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSV
 .| .|. |||.||        ..|... .||  |||.  |.|||..||.|..|. ...|.|||||...||. ...||..| ||..|..|||||. |. |
nlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

TTLVMISEIGDGP-RKCPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKnnkn
||.||. |  .    || .|| .. ..|... |...  |....||.| . |||.. . ...||...| |||  |..|||    ..... .. ....    
ttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreale....

sGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
  . .|. |||| | .|.  |.|. .|...|. |..||.. . ..||.|| | . .  ||.||..|.. |
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

0040438 (Phosphotyrosine protein) phosphatases II 1184-1450 3.7e-69 228.8 In-house 17-275 (317) alignment
Range on Protein: 1184-1450
Range on HMM: 17-275/317.0
KCKLEVEFEKLLATADEiskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
. .|. |||.||    .   ..||.| .||  |||.  |.|||..||.|.||. ...|.|||||...|.. . .||..| ||.||..|||||. || ||.
ftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

LVMISEIGDG-PRKCPRYWA-DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKnnkns
.||. |  .   .|| .||  .....|... |...  | ....| |.. |.. . .....||.|.| |||  |. ||.  . ........ ....     
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp..dhgvppspdllldfleavreale.....

GCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.  .|. |||| | .|.  |.|. .....|. |..||.  . ..||.|| | . ...||.||..|...|
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1160-1451 3.8e-69 228.2 In-house 1-290 (298) alignment
Range on Protein: 1160-1451
Range on HMM: 1-290/298.0
GNTDICIDTMASAIESLKR-KPNEGKCKLEVEFEKLLATADEISKS-CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSET
|||.|  ...  |.. |.  |....  ... ||..| .. .|| .   .|....||. ||| ..||..|  ||.|.     |.|.||||||...|.....
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWAD-DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDG
||..| ||..|. |||||..|. ..|.||. .. .  . |...|| |  . .|..| |.  ..|.   .. |.. |.. | ... .| |...  ||  | 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWp..dk

EVPEVCRGIIELVDQAYNhykNNKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
 |||. . ...|...      .....|  .|..|.|| |..||  |.|.  ...... |. ||.  . . || .|.|.... .|| |.. |.... 
gvpenatsvldllrkvra...sqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

0045450 (Phosphotyrosine protein) phosphatases II 1175-1450 8.1e-69 228.0 In-house 17-303 (307) alignment
Range on Protein: 1175-1450
Range on HMM: 17-303/307.0
SLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMR-ENSTYINASFI--------EGYDNSETFIIAQDPL
 ..... ... .|. ||||||   .... ..|... .||  |||...|.|||..||.|..|. . |.| |||||..        .|||.. .||..| ||
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

ENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWADD--EVQYDHILVKYVHSESCPYYTRREFYVTNC-KIDDTLKVTQFQYNGWPtvDGEVPEVC
..|. |||||. || ||..||..|  . | .||..|| |.  |..|... |...  | ...||.| . ||.. . . ...||.|.| |||  |. ||.  
petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp..dhgvppsf

RGIIELVDQAYNHYKNNKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKC---VDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
  ........ .........   .|  |||| | .|.  |.|. .. ..|. |..   ||.  . ..||.|| | . .. ||.||..|.. .
eelldfieevrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 883-1165 1.6e-68 226.0 In-house 21-292 (297) alignment
Range on Protein: 883-1165
Range on HMM: 21-292/297.0
KNRHKDTdygFLREYEMLPNRFSDRTTKnSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKErkKFICAQGPMESTIDDFWRMIWE
|||| |    |  |.  ||.     .|. .. | |  |.|| .|  ||. |||||..|     ||.|| || |.|.  ..|. | ||..|..|||.|...
knrhtdv...fseeflclpeaniqpqtv.aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvld

QHLEIIVMLTNLEEYNKaKCAKYWPEKVFDTkqFGDILVKFAQERKTGDYIERTLNVSKNKANVgeeedRRQITQYHYLTWKDFMAPE--HPHGIIKFIR
..  .||||....| .| |||.||..|   |  |||. |.     .   .|.|.|.|.|.|| .     || . ||... | |   ..  . . ..|.| 
eqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkaka.....rrvvkqyqfveWPdkaverkdsassllklis

QINSVYSLQRG-PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDIC
... ..| .   |.||||.||||||| |...|| . . ..|..| |...|  ||..| .|||  .|| |.| |.|..    .|.| 
evrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 879-1192 2.1e-68 225.9 In-house 12-324 (325) alignment
Range on Protein: 879-1192
Range on HMM: 12-324/325.0
ENAYKNRHKDTDyGFLREYEMLPNRfSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWR
|.  |.. .| | || .|...||.     . | . . ||  |||.... |.|..|| |   .    .|||||...  .|... |. || |. .||.|.||
ehvekkkaqdqd.gfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWr

MIWEQHLEIIVMLTNLEEyNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvGEeedRRQITQYHYLTWKDFMAPEHPHGIIKF
.. . .  ..|.|  |.. .| .||.|||... ..|.|| . ||.    .  ||. | |.| . |   ||    | . |... .|.|.  ...|  .| .
lvldWrcsvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk..Ge...trsvkqfqlqswddmGvqkrpatlisi

IRQINSVYSLQR------GPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASA
.. .. |    .      .||||||||||||||....| |..... || .| |.. |  ||..|  .|..  |||..| || ..   ||||. . .. . 
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IESLK-RKPNEGKCKLEVEFE
. ||. |.|   | ..| |||
lsslqernpltqklniekefe

0039614 (Phosphotyrosine protein) phosphatases II 1180-1450 3.8e-68 225.5 In-house 27-288 (297) alignment
Range on Protein: 1180-1450
Range on HMM: 27-288/297.0
PNEGKCKLEVEFEKLLATADEisksCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMR-ENSTYINASFIEGYDN-SETFIIAQDPLENTIGDFWRMIS
.  .| .|. |||.||   ..    .|... .||  |||...|.|||..||.|.|.. . ..|.|||||...|||  . .||..| ||..|..|||||. 
kansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

EQSVTTLVMISEIGDGPRKCPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNckIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKN
|| ||..||. .  .  |||..|| ... .|... |...  | ...||.|.. |||   . ...||.||| |||  |. ||.  . ..|..... .....
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp..dhgvppslellleflelvrealae

NknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.   .   |  |||| | .|.  |.|. .....|. |..||.  . ..||.|| | . .  ||.||..|.. .
l...pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1164-1450 2.2e-67 222.3 In-house 2-279 (318) alignment
Range on Protein: 1164-1450
Range on HMM: 2-279/318.0
ICIDTMASAIESLKRkpnEGKCKLEVEFEKLLATADEISKSCSvgENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQD
| .. ..| .. |..   .|. .|. |.|.|  . .....  |   .. |..||| . |..||. || |..|   |.| ||||..|.|| .....| || 
isvedleshvrrlre...sGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqa

PLENTIGDFWRMISEQSVTTLVMISEIG-DGPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVC
|| .|| |||||. ||  ...||....   | .|. ||| ...  .|... |.  .. .. .|. ||| ||. . ... .| |..|  ||  |  |||  
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWp..degvpesg

RGIIELVDQAYNHyknNKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 ....|| |. .    ...|| ..|..|||| |  |  .|.|. ||..... |. ||.  | ..||.||  ..    ||||.. .....
aslldlvrqvska...qqksg.agpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 896-1154 1.4e-66 219.4 In-house 10-265 (274) alignment
Range on Protein: 896-1154
Range on HMM: 10-265/274.0
EYEMLPNRFsdrTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQT-TDYINANFVIGYKER-KKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
|.  ||  |   .... |.  .. |||| .|   ...|| |   .. .  ..|||||.. ||.|. | .. .|||. .|..||||||.... ..|||||.
eflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LEEYNKAKCAKYWPEKVFD--TKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeedRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVY---SL
|.| |..|||.|.|..     ....||. .|. .  .. ||  |.| ... .        .|... | |  | |  .|.... ..........     . 
lkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.......ersvkhywytdWPdhksPddantlldlvleveesreeena

QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...|..||||||.||||  .| .  ..||.||  | . ..||.|| .|  .||. .|| ...||| 
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 883-1155 1.2e-64 212.9 In-house 12-281 (290) alignment
Range on Protein: 883-1155
Range on HMM: 12-281/290.0
KNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQ--TTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMI
 | |.  . ||  ...|| .  |. |..    ..|  .||. .|  ||. |. |  |.| .  | .|||| .. ||||.|..| .|||...|. |||..|
anghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

WEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIR
|...  |||||||  | .| || .|||..  |||..| . .|  .|... .||||.|.| .....    ......|||.  .|..    ..|..|.  |.
wqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsa....gakqsvtqyqitnwdstgkvtnpqtillvie

QIN-SVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
...   .   ...|.||||..|||.....|..  |.. . |  . ... .  .| |.  .||. .|| .... .| 
emyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt

Y_phosphatase Protein-tyrosine phosphatase 1213-1448 3.6e-64 211.8 Pfam-A 1-234 (235) alignment
Range on Protein: 1213-1448
Range on HMM: 1-234/235.0
NNMKNRSQEIIPYDRNRVILTPLPMRENstYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQY
|  |||...|.|||..|| |.  . ...  ||||....||.....||..| ||..||.|||||. .. |...||. .  . | .||..||    .....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DHILVKYV-HSE-SCPYYTRREFYVTNCKIDD-TLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnknSGCRSPLTVHCSLGTDRSSIFVAMC
..| |... ...  .  || |.. ... | .. . .|.|..|..||  | .|||  .....|...  ..      . ...|..|||| |. |. .|||. 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp..dhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvald

ILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
||...|. |..||.. . ..||.|| |...|..||.||..||.
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1213-1448 3.6e-64 211.8 In-house 1-234 (235) alignment
Range on Protein: 1213-1448
Range on HMM: 1-234/235.0
NNMKNRSQEIIPYDRNRVILTPLPMRENstYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQY
|  |||...|.|||..|| |.  . ...  ||||....||.....||..| ||..||.|||||. .. |...||. .  . | .||..||    .....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DHILVKYV-HSE-SCPYYTRREFYVTNCKIDD-TLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnknSGCRSPLTVHCSLGTDRSSIFVAMC
..| |... ...  .  || |.. ... | .. . .|.|..|..||  | .|||  .....|...  ..      . ...|..|||| |. |. .|||. 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp..dhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvald

ILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
||...|. |..||.. . ..||.|| |...|..||.||..||.
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1172-1450 2e-63 209.1 In-house 8-278 (288) alignment
Range on Protein: 1172-1450
Range on HMM: 8-278/288.0
AIESLKRKPNEGKCKLEVEFEKLlaTADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGD
 ..  ..|  ...  .. |...|  .| | .|| ..|.. .|. ||| ..|.||| .|| |. |.  ... |||||.|.|.......| .| || .|..|
pvakvakksarnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRMISEQSVTTLVMISEI-GDGPRKCPRYWADDEV--QYDHILVKYVHSESCPYYTRREFYVTncKIDDTLKVTQFQYNGWPTVDgeVPEVCRGIIELV
||... |. ..|.||..|.  .| .|| .|| |..   .| .. |. |.|.    .. |.. .   |  . |..||.|| .||  .  |||  . ..||.
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhg..vPeskapllell

DQAYNHYKNNknsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.|  .  ...       |..|||| |  |. .|.|.  |..... |. .|...|  ||| ||. |..   ||||....... 
rqvkvanqad.....tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 917-1169 2.2e-63 209.2 In-house 48-291 (439) alignment
Range on Protein: 917-1169
Range on HMM: 48-291/439.0
NACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKakcakYWPEKvfDTKQF
.  |||| |. |.| ||| |  | |.  . |||||.. || . | .| .||| . | |||||...|..   ||||||| |  |     ||| .  .   .
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcy

GDILVKFAQERKTGDYIERTLNVSkNKANVGEEEdrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYS-LQRGPILVHCSAGVGRTGTLVALDSLIQ
||| |.  .. .  .|. | ..|  |. . .| |  | . |.||..| |   | .   ...|.| |||     . ||..||||||||||||..|||  ..
gdiavrvdrnielpnyvirgfkvf.nerdtteke..rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale

QLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTM
||  |. | |   |  ||.||. .||.| ||.|.| |.|.   .|.. . || .
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 913-1154 2.8e-63 208.4 In-house 16-261 (270) alignment
Range on Protein: 913-1154
Range on HMM: 16-261/270.0
DLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVF
.   ..  ||| ||    .|||.|. ..  ..| |||||.| |... .||.|.|.||...|. .|||||||.. . |||.|.||| .. ||..|||... 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

D--TKQFGDILVKFAQERKTGDYIERTLNVSkNKanvGeeeDRRQITQYHYLTWKDFMAPEHPH------GIIKFIRQI-NSVYSLQRG-PILVHCSAGV
.  . ..|.| |   .|.|.  || . |..  .|   |   ..|... ..| || |  .|...        ..| .|.. .|  .|... |.||||||||
ekvkledgkikvlalseekeegyiltrlrle.ek...g...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
||||||.|||  .. |||. .| . . . .||..|  |||  .|| |||.|..
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

subfamily_PTPRG_pd Subfamily PTPRG 1181-1449 4.2e-63 208.4 In-house 15-285 (563) alignment
Range on Protein: 1181-1449
Range on HMM: 15-285/563.0
NEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENS-TYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQ
 .|. ... |||.|  .  . .  ..  ...||  |||  .|..||| || |.|||  ...  ||||..|.||  |. ||..| ||..|. |||||| ||
adgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

SVTTLVMISE-IGDGPRKCPRYWADDEV-QYDHILVKYVHSESCPYYTRREFYVTNCKID------DTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQA
 |...|||..   .| |||..||  ||. .|... |. ...|   .|| |.. . | |..      . ..|.|..|  ||  |  |||     .  | ..
nvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP..dhgvPehslpvLifvkks

ynHYKNNKNSGcrsPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
   . |... |   |..|||| |. |. .....  |.. .. |. |..  . ...|.||  |...  || ||| |...
..saankaeaG...PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle

subfamily_PTPN13_pd Subfamily PTPN13 896-1155 1.5e-62 206.3 In-house 16-267 (273) alignment
Range on Protein: 896-1155
Range on HMM: 16-267/273.0
EYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGlqttdYINANFVI--GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
|.. | .  .  |.. .  |||  |||| ..  ||.|||||    |     ||||...     |.. ..| .|||.  |..|||.|.|||. |.|.|.|.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

LEEYNKAKCAKYWPEKVFDTKQFGD-ILVKFAQERKTGDYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGP
  | .| || .||||.  .. .  . . |.  .  |  ..  |.|.|.....     .. |.... .. .| |   | ..  ...|....... . ..||
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.....gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagP

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|.||||||.||.|||...| ... .| . .. . ..| .||.||. .||. .|||| |.|.|.
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1186-1450 1.8e-62 206.3 In-house 23-282 (305) alignment
Range on Protein: 1186-1450
Range on HMM: 23-282/305.0
KLEVEFEKLLATadeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV
.||.....|  .    ..|. ||..|.|. |||..||...| .|.|||. .  ..| |||||...||......|.|| ||.||. ||||.| |  |.|.|
gleaqykslyee....eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MISEIGD-GPRKCPRYWADDEVQ---YDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKN
|.... . |  || .||.. . .   .... |.   ... . |. |.. ...  . ...  |.|.|   ||  |  ||.    ...|...  ...|..|.
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWP..dhGvpqfatsllslikrvqkdqkkdkg

sgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
     ||.|||| |  |. .|.|. | ...|. |. ||.   ...|||.| ..... .|| ||| |. ..
....vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel

0040439 (Phosphotyrosine protein) phosphatases II 1204-1450 4.3e-62 205.3 In-house 2-245 (249) alignment
Range on Protein: 1204-1450
Range on HMM: 2-245/249.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWA
..||.. .||  |||.. |.|||..||.|..|| .. | |||||.|.||. . .||..| ||..|..|||||. |. .|..||...       || .|| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNknsGCRSPLTVHCSLGTDRSSIF
 .....|... |.... |....||.|....|| . .....|...|| .||  |  ||.    ........ ......   .. .|. |||| | .|. .|
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleel...pkggpvlVHCsaGvgRtGtf

VAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.|. .....|. |..||.  . ..||||| | . .. ||.||..|.. .
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 882-1161 4.8e-62 204.5 In-house 11-282 (287) alignment
Range on Protein: 882-1161
Range on HMM: 11-282/287.0
YKNRHKDTDYGFLREYEMLPN--RFSDRTTKNSDlKENACKNRYPDIKAYDQTRVKLAvingLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRM
 .. |.  . ||   . .| .  .  |  | |   ..|  |||. .|  .|. || |      .  ||||| |. ||||.|.|| |..|| .|. .||..
vakghakgnegfknqftvleqvtqredevthnia.sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

IWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgEEEDRRQITQYHYLTWKDFM-APEHPHGIIKF
|.... ..||||....| .. .| .||||.  ..  .|.  ... .| .. .||||.|.| ...    ...|..|..||.. .|..    .|.   .. .
iddrnvtaivmlcqekendeevcyqyWpee..ksvvlGeyniellneevnagyierklevknkn....kagdkqqvkqyqitnWdstgkvtepqtillvi

IRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGN
 ... . .   ...|.||||..|||.....| .  |.. ..|  . ... .   | |.   ||  .||.|.. ..|   . ..
eemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1177-1453 5.8e-62 204.6 In-house 15-285 (319) alignment
Range on Protein: 1177-1453
Range on HMM: 15-285/319.0
KRKPNEGKCKLEVEFEKLlATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMI
|.  . |. .|| ||..|  .|..   . .  ..|||. ||| |.|..||| ||.|..|.  |.|.|||||||.||.. | || .| |||||| |||||.
kalastgetllekefkll.keavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

SEQSVTTLVMISEIGD-GPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVtNCKIDD--TLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAY
 |. . ..||.... . .  |. .|| . . ..| ...|.  . |    |  |.. . | | ..  | .|..|||. ||  | .|||  .....|. .  
WeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWp..dhdvPekatslldllkrir

NHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
.  .....     |..|||| |  |   |... . ......|  .|.  | ..|| ||  ...  .||.|.. |.... . 
ksrektqs....gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_PTPN23_pd Subfamily PTPN23 909-1155 8e-62 203.6 In-house 35-278 (288) alignment
Range on Protein: 909-1155
Range on HMM: 35-278/288.0
TKNSDLKENACKNRYPDIKAYDQTRVKLAvingLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
.  .  | .. |||. ||  ||..||||      .. ||||| || .      .||..|.|..||. |||.|..||. ..||||.. || .| |...|||
rsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

EKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR----GPILVHCSAGVGR
|.  .|..|||. |   ..|.|. ..||.|... ..|     .  ....  .. .| .. .|. |. ...|. ...| |. ..     |..|||||||||
edkgetvkfgdlsvtlksvretethvervlkletlda.....davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

TGTLVALDSLIQQLEEEDSV-SIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
||..  . . ...||... .  | . |  ||.|| | ||  .|. |.| | | 
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_PTPRB_pd Subfamily PTPRB 1176-1450 1.7e-61 202.8 In-house 16-284 (293) alignment
Range on Protein: 1176-1450
Range on HMM: 16-284/293.0
LKRKPNEGKCKLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRM
.|.. .. ....  |.|.| |     ...... |...|. ||| ..|.||| .|| |..|  ...| ||||..|.||     || .| || .|. |||||
vkkmkadsdlrfseeyeelkavgk..dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrm

ISEQSVTTLVMISEIGD-GPRKCPRYWADD--EVQYDHILVKYVHSESCPYYTRREFYVTNckIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAY
. |. ....||. .. . |  || .|| .|  .|.| .| |. |..|.   .. ||. ...   ... ||.|...  ||  | .|||  . ....| .  
vwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWp..dhgvPektktlldfvrtvr

NHYKNNKNsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.. .....   ..|..|||| |  |. .|.|.  |.|... | .|||...  .||..|. |. . .|| |.|......
eaiektas...krPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

subfamily_PTPRA_pd Subfamily PTPRA 1178-1450 2.4e-61 202.4 In-house 25-294 (330) alignment
Range on Protein: 1178-1450
Range on HMM: 25-294/330.0
RKPNEGKCKLEVEFEKLLATadEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMIS
..  .   ..  ||. | |.  .|  .. . ..|||. |||  .|.||| .||||...   |.| |||||||.|| . ..|| || |.|.|. |||||| 
irsaddnklfreefnalPag..piqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

EQSVTTLVMISEIGD-GPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVT----NCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQA
||  .|.||..|. .    || .|| |.  | | .| |.  ... .  || |.| |.    ... ...  |.|| ...|| |   ||   .|...|. . 
eqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv..GvPfepiGmlkllkkv

YnhyKNNKNSGCrsPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
    | |..|.   |..|||| |. |.  |...  ... .. |. ||.  . ..|| ||. ....  ||||..... .|
k...klnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_PTPN14_pd Subfamily PTPN14 894-1154 6.7e-61 200.9 In-house 26-293 (300) alignment
Range on Protein: 894-1154
Range on HMM: 26-293/300.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLqTTDYINANFV---IGYkERKKFICAQGPMESTIDDFWRMIWEQHLEIIVM
  ||| .|..  | ... . |.||| |||..|.  |...||.|.  .   .|.||||  .   .|  .....| ||||.| |. |||.|.|||....|||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvgg.kersyivaqgPleltvqdfWqmvWeqgvqlivm

LTNLEEYNKAKCAKYWPEK--VFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL
||. ||  | |. ||.|..    .| .||   |     .... .| ..|..    .     ...|..    |  | |   || ..| ........||   
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlps.....keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

---------QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
         .. |.|||||||||||| |.  | ||. || .... | ...  ||.|| .|||.| || |.|..|.
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

subfamily_PTPN1_pd Subfamily PTPN1 902-1166 2.2e-60 198.8 In-house 17-280 (290) alignment
Range on Protein: 902-1166
Range on HMM: 17-280/290.0
NRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGlqttDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAK
.  || .|....|.||  .||| |.. || .|.||   .     |||||..|   . ....| .|||. .|.| ||.|.|||.   .||| .. | .. |
keasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CAKYWPEKVF-DTKQFG--DILVKFAQERKTGDYIERTLNVSKnkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL--QRGPILVH
||.|||..   .. ..    . ||. .| ..  |. |.|.. .      . .. |.|...||.|| ||  || |   .||. .. .  ||  . || ..|
caqywPqgeeekellledtklkvkliseerksyytvrllelen.....lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRTGTLVALDSLIQQLEEEDS---VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICI
||||.||.||.. .|... ..|..|    | | .....||..|  |.|  .|  | | |.|.   . ..|  .
csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv

0042113 (Phosphotyrosine protein) phosphatases II 1205-1450 4.5e-60 198.4 In-house 1-242 (245) alignment
Range on Protein: 1205-1450
Range on HMM: 1-242/245.0
CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWA-
.||.. .||  |||. .|.|||..||.|.| . .. |.|||||.. ||. ...||..| ||..|..|||||. |. .||.||..|  .    ||..||  
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNnknsGCRSPLTVHCSLGTDRSSIFV
.....|... |...  |....||.|.. ||| . | ...|....| .||  |. ||.  . ...... . .....    .   |. |||| | .|.  |.
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp..dhgvpdllellldflefvrkalae....dsngpvlVHCsaGvgRtGtfi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
|. .....|. |..|..  . ..||||| | . .  ||.||..|....
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1175-1450 8.1e-60 197.8 In-house 24-290 (319) alignment
Range on Protein: 1175-1450
Range on HMM: 24-290/319.0
SLKRKPNEGKCKLEVEFEKLLATADEISKScSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWR
| |.. .. . |||||| ..   . . ..  .  . ..|  |||  .|...|.|.| | .|   | | ||||||..|| . . .| || ||.||. ||||
snksdfdddltklevefrracklgvnladq.tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWr

MISEQSVTTLVMISeigdgPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAy
|| |. ..|.|...       || .||  .  .....  ||    | .  |. |.. ...  |  |  |.||| . ||| |   ||.    .. ||..  
miweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdv..Gvpdypsdlmrlvkkv.

NHYKNNKNSgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.| .. .|   | .. |||| |. |. ..... .|.. .. || ||.  . | || ||  |.....|| |.. |... 
rhltskenh..ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_PTPRK_pd Subfamily PTPRK 1206-1449 1e-59 196.9 In-house 36-275 (314) alignment
Range on Protein: 1206-1449
Range on HMM: 36-275/314.0
SVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADD
 .  ..||..||||..|..||| ||.|...    .| ||||..|..| ... ||..| ||..|. ||||.. ..  ...||..|. .    || .|| .|
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

EVQYDHILVKYVHSESCPYYTRREFYVTN--CKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNnknsgCRSPLTVHCSLGTDRSSIFV
  .|..| |..|..|    .  | | |..   . ... .| |||. |||.   .||   .|...|| .  .. ..        .. |||| |. |. .|.
tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.....eaGrivvhCsaGaGrtGtfi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
|..|... .. |. ||.  . ..|||... ...   || |.. .|..
aidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

0045098 (Phosphotyrosine protein) phosphatases II 1201-1450 1.5e-59 197.0 In-house 21-271 (278) alignment
Range on Protein: 1201-1450
Range on HMM: 21-271/278.0
ISKSCSVGENEENNMKNRSQEIIPYDRNRVIltplpmrensTYINASFIEGYdnSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPR
|  .....  ..|  |||  .|.|||..||.           |||||.|.||  . .||..| ||..|. |||||. |. .|..||. | . .|  ||..
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNC----KIDDTLKVTQFQYNGWPtvDGEVPEVC--RGIIELVDQAYNHYKNNKNS--------GCR
|| ... ..|... |...  | ...|| | ..|||.    . . ...||...| .||  |..||.    . ..||...  ...|.  .         .  
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwp..dhgvpslpilksflellefirealkllaslllsslllldsg

SPLTVHCSLGTDRSSIFVAMCILVQHLrlEKCVDICATTRKLRSQRTG-LINSYAQYEFLHRAIINY
 |  |||| | .|.  .||. .. ..|  |. ||.  . ..||||| |  . .  ||.||..... .
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1206-1452 9.9e-59 193.5 In-house 2-243 (250) alignment
Range on Protein: 1206-1452
Range on HMM: 2-243/250.0
SVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWA-DD
||... .|. |||  .||..|  ||.| .    ..| ||||||..|||....||..| ||..|| |||||. |. ..|.||.... .  .....||  . 
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek

EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNhykNNKNSGcRSPLTVHCSLGTDRSSIFVAM
  .| ...|.   .|    || |.. ... |  |   | |...  ||  |  |||| . ..||...      .....|  .|. |.|| |. ||  |.|.
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWP..dkgvPevatavLellkkvqa...sqqqag.naPvivqCsaGvgrsGafiai

CILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
  ....|. || ||.    ..|| .| . ..| .|| |....|... |
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_CG7180_pd Subfamily CG7180 893-1155 4.4e-57 188.0 In-house 19-288 (296) alignment
Range on Protein: 893-1155
Range on HMM: 19-288/296.0
FLREYEMLPNrFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLT
.  |... |. ..  . .    |||  |||....  ||..|| |  ..| ...||||| .| ..   |..|  ..|...|.|.|||...... . .|.||
yklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

NLEEYNKaKCAKYWPEKVfdTKQFGDILVKFAQERKTGDYIERTLNVSKN-----KANVGEEEDRRQITQYHYLTWKD-FMAPEHPHGIIKFIRQINSVY
.  ...| .. .|||.|    .|.|.|.|.  .|..  .   ||. . |.     . . ... . | ...... .|.     |    ..|...|..... 
ktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

SLQ-----RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
        .||..|..| |..|.|  .|.|  ....|.|. | ... |  ||..|. ||.. ..| ..|  ||.
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1209-1451 4.5e-57 188.7 In-house 21-255 (284) alignment
Range on Protein: 1209-1451
Range on HMM: 21-255/284.0
ENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISeigdgPRKCPRYWADDE-VQ
. ..|  |||  .|...|.|.| | .|   | | |||||||.|| . . .| .| ||.||. |||||| |. ..|.|...       || .||  .  ..
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivik

YDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAyNHYKNNKNSgcRSPLTVHCSLGTDRSSIFVAMCI
...  ||    | .  |. |.. ...  |  |  |..|| . ||| |   ||.    .. ||..  .| .. .|   |... |||| |. |. ..... .
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdv..gvpdypsdlmrlvkkv.rhltskenh..ranivvhcsagvgrtgvyivldv

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|.. .. || ||.  . |.|| ||. |.....|| |.. |...  
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

0037934 (Phosphotyrosine protein) phosphatases II 1205-1450 6.1e-57 188.3 In-house 2-241 (243) alignment
Range on Protein: 1205-1450
Range on HMM: 2-241/243.0
CSVGENEENNMKNRSQEIIPYDRNRVILtplpmrENSTYINASFIEGYDNsetFIIAQDPLENTIGD----FWRMISEQSVTTLVMISEIG-DGPRKCPR
.|..  .||  ||| . |.|||..||.|      |.| ||||..|.....   .|. | ||..|. |    ||||. |. .|..||. |    |  ||..
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWAdDEVQYDHILVKYVHSESCPYYTRREFYVTNCK-IDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKN-----NKNSGcrSPLTVHCSL
||  .||.|... |.....|....|| |.....|..  | |. |....| .||  |. ||. .  .....|........     . .||  .|. |||| 
ywp.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp..dhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsa

GTDRSSIFVAMCILVQHLrlekCVDICATTRKLRSQRTG-LINSYAQYEFLHRAIINY
| .|.  ..|. .. ..|    .||.  . ..||.|| |  . .. ||.||..|.. .
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 916-1154 1.6e-55 182.9 In-house 2-236 (237) alignment
Range on Protein: 916-1154
Range on HMM: 2-236/237.0
ENACKNRYPDIKAYDQTRVKLAVINGLqtTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVfDTK
||  |||| .|.|||..|| |    .   .|||||... |.    ||.|.||||.||. ||||.|.|...  .||||| | | |. || ||||.   . .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpa

QFGDILVKFAQERKTGDYIERTLNVSKNKANVgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN--SVYSLQRGPILVHCSAGVGRTGTLVALDS
 .| . | . .. .  ||  |.| .||.        . | | ||.. .| |   |..   ...| ..|   | .  . || ..|||||||||| .. .|.
aygvltvslkkkeefsdytvrslllskrltlk....evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida

LIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...| .|.  | ||| |  .  .| ...|.  ||.|.....|
mlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1182-1452 3.4e-55 181.9 In-house 17-284 (290) alignment
Range on Protein: 1182-1452
Range on HMM: 17-284/290.0
EGKCKLEVEFEKLLAtaDEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMREN--STYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQ
.|. . . .|..| .   | ...  ||  ..|. .||...|..|| ||..| |.. ...    ||||..|.|| ... .|..| |..||. |||..| ..
kgnegfrnqfkmlds..gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

SVTTLVMISE-IGDGPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNCKI-DDTLKVTQFQYNGWPTvDGEVPEVcRGIIELVdqaYNHYK
.|| .||. . | .|  ||  ||.| .  .|... .| .. |.. .|..|.. |.| .  ... .|||.|   |.  .|.|..   .|. ..   .. ||
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwds.tgkvtnp.qtillvi...eemyk

NNKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
... .| . .. |||| .  ||..|.|. . ... . |  .|. .  ...|.|. |....  ||..... ...| |
tqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 910-1154 3.5e-55 181.8 In-house 31-274 (287) alignment
Range on Protein: 910-1154
Range on HMM: 31-274/287.0
KNSDLKENACKNRYPDIKAYDQTRVkLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEK
|...   .. |||| |.  .|.||| | . .| . .||||||.| .|.. ..||.||||. .|. ||||...|..   ....|   |  . || |||||.
kaaeelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

VFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR-----GPILVHCSAGVGRT
    .  |  .| . .. |  .|  |.| . . ...     . | . |...|.| |  ..    |.|.|. ...    |.|     ||..||...|.||.
evPmrvGGysvvlldydikePeygvralrlidletr.....earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrs

GTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
|.|.|.  |...||.   | . ..|  || .|. |||.  |. .|| || 
GillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1184-1452 1.1e-54 180.5 In-house 14-277 (281) alignment
Range on Protein: 1184-1452
Range on HMM: 14-277/281.0
KCKLEVEFEKLLATadEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
.  .  |.||| |   ..... .  ...|| .||| . |. ||  || .||    .|. ||||.|..||.. . .|..| |. ... .||.|. ||.|..
naGfieeyeklaai..gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

LVMIS-EIGDGPRKCPRYWADDE--VQYDHILVKYVHSESCPYYTRREFYVtNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKN
.||.  ||  |  || ||| ||.  ..| .. || ...|. . | .|.| . . .  .| .|.|..|  ||  |  ||.  . ..|  .. ..  .....
ivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWP..dhGvPattkellefrkevlkltekktk

sgcrSPLTVHCSLGTDRSSIFVAMCILVQHLR-LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
     || .||| |  |.  ..|.  ||...   .. .|..|. ..|| .|. .. . .||||...|.... |
....aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_PTPRN_pd Subfamily PTPRN 894-1153 9.1e-54 177.2 In-house 32-288 (297) alignment
Range on Protein: 894-1153
Range on HMM: 32-288/297.0
LREYEMLPNRFSDRTT-KNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERK-KFICAQGPMESTIDDFWRMIWEQHLEIIVML
 .|.| | .  .. .| . .. ..|. |||. .. .||..||||   .  ...||||| ...    |.  .| .|||. ||. |||.|.|||   .||.|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

TNLEEYNKAKCAKYWPEKVFDTKQFGDILVkFAQERKTGDYIERTLNVsKnkaNVgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRG
|.||| .  .|..|||..  .. .. .. .  ..   . ||. |.. . |   |. . .. | .||.|.|.|..  .|  .. ...| |..|  |  .  
trleeegvkqckrywpdeGsevyhiyevhl.vsehiwcddylvrsfyl.k...nl.qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrsc

PILVHCSAGVGRTGTLVALDSLIQQLEE-EDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
||.||||.|.||||. ...| ....|      . |  |.  || ||. ||.. .|. | . |.
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 883-1178 1.4e-53 176.7 In-house 15-257 (392) alignment
Range on Protein: 883-1178
Range on HMM: 15-257/392.0
KNRHKDTdygFLREYEMLPNRFSDRTTkNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWE
||||      |  |.  ||.    ..|  .  . |  |||| .|  ||..|||| ||.    .||.|| .. ...  | .|..|||  ...||||||...
knrhsal...ffeefhdlpgpdiypqt.vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfq

QHLEIIVMLTNLEEYNkakcakywpekvfdtkqfgdilvkfaqerktgdyiertlnvsknkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQI
..   |.|.|.|.| .                                                   .| | ..|.|.  | |   |.|   ..|||...
envttiamvtklkegd.................................................kgddartvaqfhftewPdkdvpkhtssllkfikev

NSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKR
.. .     |...|||||||||| ....||.. . ..   | ..| | ..|..| ..||. .|| |.| |.|.   . || | .  ..  .. |. 
kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 906-1169 3.4e-53 175.4 In-house 22-278 (283) alignment
Range on Protein: 906-1169
Range on HMM: 22-278/283.0
DRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGlqttDYINANFVI---GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKC
|. .. .  .||  |||. .| ..|| ||.|   .     ||||| |..    ||. ||.| ||.|.. |. |||.|.....   |||||.| | .. ||
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

AKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHYLTWkdfmAPEHPHGIIKFIRQINSVYSLQ----RGPILVHCS
..|||..   ....|.  |   .|     .| . | . .|    .  ..   .. | .  |        .  ||  . ..| | |||    .|||.||||
sqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvn....ssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCs

AGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTM
.|.|||....|. . ....  |  | ....|  .| ||  .||.| || ... . |.    |.|.|    .
tgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl

subfamily_PTPN9_pd Subfamily PTPN9 1209-1451 4.8e-53 175.1 In-house 38-290 (297) alignment
Range on Protein: 1209-1451
Range on HMM: 38-290/297.0
ENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DD
.   |  ||| .... ||. || |. ..  |.| ||||.|..|| . ..|| .| ||..|. |||||. ||.| ..||.  . . | .|| .||    ..
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYK--------NNKNSGCRSPLTVHCSLGTD
  .. .. |. |. |.   |. | . ..| | ... ||| ||. .||  |  ||. .  ........ ..          ..|      |. |||| |  
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWP..dyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|.  |... | ...|. .  ||.. | ..||.||.  |    |||| . |...|.
rtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 884-1153 6.7e-53 174.3 In-house 11-289 (301) alignment
Range on Protein: 884-1153
Range on HMM: 11-289/301.0
NRHKDTdygFLREYEMLPNRFSDRtTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL--QTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
. |...   |  .|. | .  ... .. .  .||.  ||. .|. ||. |. |.  . |  ....||||... ||.|.|||| |||||..|. ||||.||
akhsnk...feeqykelkegedks.ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVS----------KNKANVGEEEDRRQITQYHYLTWKDFMAPEH
...   |||.|||.|  |.|| .|||.   ....|| . |.. .|    |.. | |||           . | .| .. . ....|..   | .      
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

PHGIIKFIR-QINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
|. ... |  .|    .   ||..||||..|.|.|. ....  . |   |  | ... .  .|...   |. |.||...| ..
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

subfamily_PTPN12_pd Subfamily PTPN12 1186-1451 9e-53 174.0 In-house 9-277 (290) alignment
Range on Protein: 1186-1451
Range on HMM: 9-277/290.0
KLEVEFEKLLATADEIS----KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSV
... ||.|| .....       | ..||.|||  ||| ..|.||| .|| |.     |.| ||||.||.| ... ..| || || .|. |||||| |..|
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

TTLVMIS-EIGDGPRKCPRYWADD---EVQYDHILVKYVHSESCP-YYTRREFYVTNCkiDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYK
. .||.  |.  |  || |||..    |...... |.  . . .   .. | . |..   ... ||.||.|. ||  | .||.    ..||.... .. .
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWP..DhgvPssaksllelielvrelqe

nnknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKC---VDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
        .|| |||| |  |  . .|. .  . |. ||    .|.    ..|| ||. |. .  |||....|.... 
.....sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_PTPN6_pd Subfamily PTPN6 1172-1452 9.6e-53 174.1 In-house 12-298 (306) alignment
Range on Protein: 1172-1452
Range on HMM: 12-298/306.0
AIESLKR-KPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTpLPMRENSTYINASFIEG--YDNSETFIIAQDPLENT
 .. |.. . . .|  .| |||.|  .. .   | . |.  ||. ||| . |.|.| .||||.  |   .|.||||..|..   ......| .|  ||.|
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett

IGDFWRMISEQSVTTLVMIS-EIGDGPRKCPRYWADDEVQ--YDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPtvDGEVPEVCRGI
. |||||. ... . .||.  |.  |  || ||| | | .  | .| |. |...|  .|. ||. |..  | ... .| |.... ||  |  ||.    .
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWP..dhgvpkdpgav

IELVDQAYNHYKNNKNSgCRSPLTVHCSLGTDRSSIFVAMCILVQHLR---LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
......  ..... ...    |. |||| |  |   |. . ||.. ..   |.  .||  . ...|.|| ||..  .|| |...|| .| .
Ldfledvnrkqeeleea.eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1206-1448 4.1e-52 172.1 In-house 42-276 (315) alignment
Range on Protein: 1206-1448
Range on HMM: 42-276/315.0
SVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADD
 |  . ||  |||  .||.||. || |  |   ..| |.||.||.||.  . .| || |. ....||||.. |. ....||.... .|  ||. .|| |.
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

EVQYDHILVKYVHSESCPYYTRREFYVTNckIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKnsgcrSPLTVHCSLGTDRSSIFVAM
.| | .| |  .  |    || | . |.    |.  .| |..|  ||  | .||. .  ...|. ..  | .|.      ... |||| |  |.  |...
kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswp..dmgvpkytiplmnlirtvkqhhtnsv.....gaivvhcsaGvGrtGtfitl

CILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
  .....  |. .|.    ...|..| ..... .||.|.. |..
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

0051429 (Phosphotyrosine protein) phosphatases II 943-1178 8.8e-52 171.7 In-house 2-245 (272) alignment
Range on Protein: 943-1178
Range on HMM: 2-245/272.0
QTTDYINANFVIGYKE---RKKFICAQGPMESTIDDFWRMiWEQHLEIIVMLTNLEEYNKAKCAKYWP----------EKVFDTKQFGDILVKFAQERKT
....||||..| ||     ........||.. |..||||. .|...  ||.|...||... || .|||          . .. |  .|.. |.. .|  .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GDYIERTLNVSKNKANVGEeedrRQITQYHYLTWKDFMAPEHPhgIIKFIRQINSvyslqRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVS-----
 ||| |.| ...   .       |.....||. | |. .|...  ..........      ||.|||||||..||||.|||. |......|. |      
ldyilrellltlllsagea....revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---IYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTgTFGNTDICIDTMASAIESLKR
   ....|  || ||   ||.  ||.|||.|||.    . ...  .....|.. ...
nlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1213-1451 1.1e-51 170.5 In-house 28-268 (274) alignment
Range on Protein: 1213-1451
Range on HMM: 28-268/274.0
NNMKNRSQEIIPYDRNRVILTPL-PMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADDEVQ--
.. ||| ..|.| .. ||.|..  .  |.|.|||| .| |||.  .... .| || ||. |||||| ...|. .||. .. .  . || .|. |.|    
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

---YDHILVKYVHSESCPYYTRREFYVTNCKIddTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAM
   |... .| ..  ..  |. |.... ...   . .|. . |  ||  | ..|.  . ...||..   . ......  ..|  |||| |  |  .|.|.
serygdveikvekiverndysvrklvlkyler..ersvkhywytdWP..dhksPddantlldlvlev..eesreeenaklapvvvhCsaGiGrtGcfiai

CILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
 | |..|| |. ||.  .. .|| .| |....  |||..|||.. | 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_CG7180_pd Subfamily CG7180 1184-1448 1.4e-51 169.9 In-house 12-287 (296) alignment
Range on Protein: 1184-1448
Range on HMM: 12-287/296.0
KCKLEVEFEKLLATADEIS-KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVT
. | .||....| .. ...   |  | ..||  |||  ...||| |||.|. |   |.| ||||......   . .|. . | ..|...|||.. .. . 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TLVMISEIGDGPRKCPRYWADD-EVQYDHILVKYVHSESCPYYTRREFYVTNC---------K-IDDTLKVTQFQYNGWPTvDGEVPEVCRGIIELVDQA
..|.... .|  ...| ||  . . || .|.|..|.... .  . |.| .|           .   .|  |..||.  |.  . .|| .  ..|||. ..
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWel.edkvPlstnalielrrrv

YNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
    .....   ..|. |..| |. || ...|. . .. .. |..||.    ..|| .| .|...  .| ..   . 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1195-1453 4.4e-51 168.6 In-house 29-280 (287) alignment
Range on Protein: 1195-1453
Range on HMM: 29-280/287.0
LATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDG
|   ..  ..  ..  ..|. |||...|...| .||.|      |.  ||||.||.|| ..  ||||. |. ||. .||..| .. ||..||...   . 
leqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekend

PRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNCK-IDDTLKVTQFQYNGWPTvDGEVPEVCRGIIELVDqaynHYKNNKNSGcRSPLTVHC
 ..| .||.... | . .  .. .. |    |. |.. |.| .  .|...|.|.|.  |.   |.|.|    .. . .     ||... .| .... |||
eevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWds.tgkvtepqtillviee....myktqrkrg.ntsivvhC

SLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
| .  ||..|.|. . ... . |  .|.    .. | |. | .   .||.|.  ....| | 
sdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

0041856 (Phosphotyrosine protein) phosphatases II 917-1162 7.9e-51 167.5 In-house 1-176 (182) alignment
Range on Protein: 917-1162
Range on HMM: 1-176/182.0
NACKNRYPDIKAYDQTRvklavinglqTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTnleeynkakCAKYWPEKVfdtkqf
|  ||||.||  ||..|            ||||||...|.   ..||..|||. ||. ||.||..|..  .||.||         .  ||||..      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdilvkfaqerktgdyiertlnvsknkanvgeeedRRQITQYHYLTWKDFMAPEhPHGIIKFIRQINSvyslQRGPILVHCSAGVGRTGTLVALDSLIQQ
                                    |...||.|| | |. .|. .. ...||.....    . ||.||||||||||||||||.. ....
...................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl

leeedSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNT
     .||....|. .| .|.  |... ||.||..|||.   ...|
.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_PTPN23_pd Subfamily PTPN23 1173-1451 4.5e-50 165.1 In-house 3-280 (288) alignment
Range on Protein: 1173-1451
Range on HMM: 3-280/288.0
IESLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGY-DNSETFIIAQDPLENTIGD
.| |.||  .|| .|. .|..|  . |. ... |.   . .  ||||..|.|||.||| |      ..  ||||||...    . .||..| ||..|..|
veelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnD

FWRMISEQSVTTLVMISEIGD-GPRKCPRYWAD---DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdGeVPEVCRGIIEL
||.|. || . ..||. .  . |  |. |||     . |..... |   . .. ... .|.. ..  . | . .|.  |.. || . | ||.    ....
FWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpel.G.vPasPetllqf

VDQAYNHYKNNKNSgCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK-CVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
.|.. ..|.....  .. || |||| | .|. .|  .   |. |. ..  .||    ..|| ||   ..  .|..|.  |.... 
ldevesayeavqrk.sktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1188-1450 1.5e-49 163.7 In-house 26-283 (297) alignment
Range on Protein: 1188-1450
Range on HMM: 26-283/297.0
EVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNseTFIIAQDPLENTIGDFWRMISEQSVTTLVMI
.|. |..| .     ..  | |.  |  |.| . |.|||..||.|  .    .| |.||||..|. .   .|  | | ..|. |||.|. .. |.|.||.
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

SEIGDGPRKCPRYWADDEV-QYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSgcrsP
..  .. .|| |||.|. | .. .. |.    ...  . .||. ||. |   .  | |.|.  ||. . |  .  . ...|...  .....|...    |
nddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg....P

LTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
| |||. |  | ......   | . . || |||  . .||| .|  |.    ||.|.. |....
llvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1205-1450 3.3e-49 162.4 In-house 36-276 (315) alignment
Range on Protein: 1205-1450
Range on HMM: 36-276/315.0
CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWAD
  |. ...|  ||| ..|.|.|..||.|  .    .| |||||.|...|. ...| .| ||. .. |||||. .. |||.||...  .| . || .|| |
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd

---DEVQYDHILVKYVHSESCPYYTRREFyVTnCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHykNNKNsgcRSPLTVHCSLGTDRSSI
   | |..  | |. .  |..   . |.. ||  | ... .|||||...||  |  |..    ...|. .      |.|.     .| |||| |. |. .
rkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewP..dkGvdkqtssllklikevkad..ngkk...efsllvhcsaGvGrtGv

FVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
....   |.... .. ||.  . ..||..|  |...  .| |.. |. ..
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1207-1450 1.5e-48 160.2 In-house 37-275 (515) alignment
Range on Protein: 1207-1450
Range on HMM: 37-275/515.0
VGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRK-CPRYWAD--
| ..| |  ||| ..|.|||..||.|  .    .| |.|||.|...||  ..| .| |.. .. ||||.. .. |||..|...  .| .  | .|| |  
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

-DEVQYDHILVKYVHSESCPYYTRREFYVTncKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNSGCrSPLTVHCSLGTDRSSIFV
 | |.. .| |. |  |.|   ..|.. |.  | ||.  ||||....||  |  ||. .. .. |. .     | ...     || .||| |  |  ...
gdsvkfGsikvelvsleactggikrkltvl..kgddsrtvtqfhfteWP..dkGvpkhtssllklikev....kadhgqyt.hpliihcsaGvGrtGvvi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
..   | | .  . ||.  . ...| .|  |.    || |.. |. ..
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_PTPN14_pd Subfamily PTPN14 1174-1450 2.9e-48 159.4 In-house 14-295 (300) alignment
Range on Protein: 1174-1450
Range on HMM: 14-295/300.0
ESLKRKPNEGKckLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMReNSTYINASFIEGYDN--SETFIIAQDPLENTIGD
. |..| .|||  . .|.|..          .|.....||. ||| ....||. ||| |.|     .. ||||| |.      . ..|.|| |||.|. |
kilekkleegk..vfteyeripkkre..dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqd

FWRMISEQSVTTLVMISEI-GDGPRKCPRYWADD-----EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGII
||.|. || |. .||. |.  ||  |. .|. ..     .|....  |    ||. . .. . . .      .  .|  .||. ||  | .|||  .| .
fWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp..dhgvPeDvkgfl

ELVDQAYNH-YKNNKN---SGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
. ...     .| |..      . |. |||| |  |. . .   .|.. |  .. .||  . ..|| ||  |... |||.|.....|.|
syLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_PTPRN_pd Subfamily PTPRN 1183-1449 3.9e-48 158.7 In-house 27-290 (297) alignment
Range on Protein: 1183-1449
Range on HMM: 27-290/297.0
GKCKLEVEFEKLLATADEiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSV
 | .|| |.| | |   |  ....|...|.|  ||||....||| .|| |.    .|.| |||||.|   |    ..| .| || .|. |||.|. || |
nkdrlekewealcayeae.pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

TTLVMISEIGD-GPRKCPRYWADDEVQYDHILVKYVHSES--CPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKnn
. .|..... . | ..| ||| |.  .  ||    . ||   |  |  | ||. | . ..|  |||| .  ||    .||   . ..|.  .    |.  
vvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee..gvPasaksllefrrkvnksyr..

knsGCRSPLTVHCSLGTDRSSIFVAMCILVQHL-RLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
   |  .|. |||| |. |. ..... .....| .  | .||.||  .|| ||.||... .|.||   |...
...GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 916-1155 5.5e-48 158.2 In-house 6-238 (239) alignment
Range on Protein: 916-1155
Range on HMM: 6-238/239.0
ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfdTK
 | .|||| .| .||..|| |  ..    .|||||...  |    | .|..|| .| .  |||||.|...  .||||| | |  | || .|||.    | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGDILVKFAQERKTGDYIERTLNVSKnkanVGEEEDrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLI
.. .. | . .     ||| ||. .|.    ||. |. | . |||.  | |   |..   .. . |.|         | ..||||||||||... .|...
kycnlrvtlrktevfadyiirtfvmsq....vgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

QQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
.| ... .| |.| |  .| .| ..||. .||.|.. |.|.
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1194-1450 7.7e-48 158.3 In-house 31-287 (325) alignment
Range on Protein: 1194-1450
Range on HMM: 31-287/325.0
LLATADEISKScsVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG
|| . | |.|   |    ||  ||| ......|..||.|  .    .| |||||... . . ..|. || || .||.|.||.. .   . .|.. |.  |
llpsddgiakk..vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlg

PRKCPRYWADD---EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWP-TVDGEVPEVCRGIIELVDQAYNHYKNNknSGCRSPLTV
  .|  || ..    ...  . || .  |    |  | . | . |  .|. | |||. .|.     . |     |..||..  .  . |  . . .|. |
kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan..tkastpilv

HCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
||| |  |. .|...  .....  |  |||    .||| .|  ....  || ... |....
hcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea

0049772 (Phosphotyrosine protein) phosphatases II 902-1155 7.9e-48 159.1 In-house 31-278 (314) alignment
Range on Protein: 902-1155
Range on HMM: 31-278/314.0
NRFSDRTTKNSDLKENACKNRYPDIKAYDqTRVKLAVINGlQTTDYINANFVIGYkerKKFICAQGPMESTIDDF----------WRMI--WEQHLEIIV
.  .. |.. .|| .|  ||||.||  .| .||.|   .. ...|||||..| |.   .|||..|||.| |..||          |||.  ..... .||
svlpeltilvadlflnrdknryldilpad.nrvilpglpv.sgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LTNLEEYNkakcaKYWPEKVFDTKQfgdilvkfaqerktgdyiertlnvsknkaNVG--EEEDRRQITQYHYLTWKDF
|                     |..| ...      ..... ... .                             ..    |   |.. .|... . |.
msrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.............................eelydpelferlgikylripvpDg

MAPeHPHGIIKFIRQINSVysLQRGPILVHCSAGVGRTGTLVALDSLIQQLeeedSVSIYNTVCDLRHQRN-----FLVQSLKQYIFLYRALLD
 ||  .  . .|.. |...   . ||.||||.||.|||||.|... |. .|     ||.  .. |.| .|       ....|.||.| ..|||.
sap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 916-1154 7.9e-48 157.7 In-house 7-238 (239) alignment
Range on Protein: 916-1154
Range on HMM: 7-238/239.0
ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfdTK
 | .|||| .| .||..|| |  ..    .|||||...  |    | .|..|| .| .  |||||.|...  .||||| | |  | || .|||.    | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGDILVKFAQERKTGDYIERTLNVSKnkanVGEEEDrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLI
.. .. | . .     ||| ||. .|.    ||. |. | . |||.  | |   |..   .. . |.|         | ..||||||||||... .|...
kycnlrvtlrktevfadyiirtfvmsq....vgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

QQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
.| ... .| |.| |  .| .| ..||. .||.|.. |.|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 898-1155 9.3e-48 157.8 In-house 23-275 (307) alignment
Range on Protein: 898-1155
Range on HMM: 23-275/307.0
EMLPNRFSDRTTKnSDLKENACKNRYPDIKAYDQTRVKLAvINGLqTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEY
..| ..  .  |    .. |. |||| |.|. |..|. .  ..|| ..||| ||..    . |||||||||.|.|. .|| |. ....| ..|| .. | 
rvlakktpegvtv.eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviel

NKAKCAKYWPEKVFDTKQFGDILVKFAQE---RKTGDYIERTLNVSKNKANVGEeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvyslQRGPIL
 | || .||| .  ... ||.     . .    |.    |  .||.. | . ..  . | |... .  | |  .|.   . | ..  ..     .. |..
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaq..ksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvv

VHCSAGVGRTGTLVALDSLIQQ-LEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|||||||||.||.||.  . .. .. ..  .. . | .|| ||.. .|.  ||..|.| ||.
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_PTPN3_pd Subfamily PTPN3 1188-1451 1.7e-47 156.7 In-house 18-275 (280) alignment
Range on Protein: 1188-1451
Range on HMM: 18-275/280.0
EVEFEKLLATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIE----GYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
 ..||.|     ..  ..|.    ||  ||| ..|.|||  ||.|.     ... ||||....    . . .  .|..| ||..|  |||.|. ||....
laqfeqlyrkkpgl..aisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

LVMISEI-GDGPRKCPRYWA--DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnkn
.||. ..  .|  || .||   .||..| .. ||  ....   |  ||..... . ..  |..|.||  ||  | .||.    ..|.|..  .       
ivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWp..dhgvPddsadflefvervrklr.....

SGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|| ..|. |||| | .|. ..... . .. .  .. | . .  |..| ||. |... .||.|.  ||.. .
sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1203-1449 6.6e-47 154.7 In-house 23-264 (283) alignment
Range on Protein: 1203-1449
Range on HMM: 23-264/283.0
KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMrensTYINASFIE---GYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCP
... .  ..||. ||| |||.|.|..|| | ...     .||||.||     |.... .|||| ||..|. |||.|. .. .|..||.... .. | || 
ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

RYWADD-EVQYDHILVKYVHSESCPYYTRREFYVTNC-KIDDTLKVTQFQYNGWptvdG---EVPEvcrgIIELVdqAYNHYKNNKNSGCRSPLTVHCSL
.||  .  ..|    |   .  .   ....|. . .     .|| .. .|...|        | .     |  ||   .|  . ...   ..|. |||| 
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqai....inslv..kfnkvislqteskkgPivvhCst

GTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
|  |...|.|.   |.... |  ||. |. . .| || ... .  || ..| ....
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 913-1158 1.1e-46 153.8 In-house 52-284 (290) alignment
Range on Protein: 913-1158
Range on HMM: 52-284/290.0
DLKENACKNRYPDIKAYDQTRVKLAviNGlQTTDYINANFVIGYKerKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFD
|   .  |||| |.   |.||| |   .| .  ||. ||.| | |    || .||....|. |.|||. ...   |||| .| |  ||||..|.|||  .
dkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

TKQFGDILVKFAQERKT-GDYIERTLNVSKNKaNvGEEedrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVyslqRGPILVHCSAGVGRTGTLVALD
.  ||.| |  ..| .   . | .|| | . . . | |    ..  ..  .| |   .     ... .| .  .     ||. ||||||.|||||.||..
vltfGeitvlcseeddkdaniikktlsvrdkd.s.Gke...hklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaie

SLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGT
  .| | .  .. . ..|  ||. |   ||   ||. | ..||| | 
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1186-1451 9.1e-46 150.9 In-house 11-277 (287) alignment
Range on Protein: 1186-1451
Range on HMM: 11-277/287.0
KLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV
... |...|   ..  .      |.  .  |||  ...|.| .||.|.  . .  | |||| .. .| . |.|| || |.  |..||||.. |. .....
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MI-SEIGDGPRKCPRYWADDEVQY---DHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKNS
..  |. ..  || .|| . ||      . .|   ..   | |. | . . . .  ..  | |...  ||  |. ..  . |.| .| .  .| . ....
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswP..dkvlaPtavglirfvldvkqhielarda

GCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
    || ||.. |  || |..|. .||. |     ||. |.  .|| .|..|...  |. .|  |.. | 
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

0036282 (Phosphotyrosine protein) phosphatases II 945-1150 1.1e-45 150.7 In-house 2-163 (174) alignment
Range on Protein: 945-1150
Range on HMM: 2-163/174.0
TDYINANFVIGYKERKKFICAQGPMEstiddFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvfdtkqfgdilvkfaqerktgdyiertlnvsknka
.|||||... ..   ...|. |||..     ||.|..|......|||....| .. ||  ||||                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

nvGEEEDRRQITQYHYLTWKDFMAPEHPHgIIKFIRQINSVYSL-QRGPILVHCSAGVGRTGTLVALDSLIQQLEeEDSVSIYNTVCDLRHQRNFLVQSL
    |  .| . ||.|| | |. .|. .  ...|........|  . ||.||||||||||||||||.. ....|. |. | ....|  || ||   ||. 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

KQYIFLY
 ||.|||
sQyrfly

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 895-1155 2.8e-45 149.6 In-house 23-269 (288) alignment
Range on Protein: 895-1155
Range on HMM: 23-269/288.0
REYEMLPNRFSDRTTKNsdLKENACKNRYPDIKAYDQTRVKLAvingLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNL
.||.  ||  | .. ..    .|....|| ..   | |||||       .  ||.|| |   | ....|||| |...||. .|.|. |. .| ||||..|
keyrdspneasidiids..fianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcel

EEYNKAKCAKYWPEKVFDTKQFGDIlVKFAQERKtgDYIERTLNVSKNKANVGEeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQInsvYSLQRgPIL
 |  | | |.|.| |. .. ..| .  .  ....  . |.....||  . .    |..  . . |.| |.|   ||     ....  .    |||. ||.
lekGkeksaeyfPsklGekarigrl.ctvvkkkr..adidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevl...kslqk.Piv

VHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
||.||||||||||.     ...|  .| ..| . .  || .|   .|. .||....| .|.
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1205-1452 4.8e-45 148.6 In-house 12-265 (270) alignment
Range on Protein: 1205-1452
Range on HMM: 12-265/270.0
CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA
 .. |   ..  ||...|.|  . ||.| .|   ....|||| ...|.|.. ...| |. ||..|. .||||| |. ||..||.... . | .|| |||.
sdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKID---DTLKVTQFQYNGWP--TVDGE--VPEVCRGIIELVDQAYNHYKNNKNSGcrsPLTVHCSLGT
 .  .  ..    ..  ..    .. . .|. ..    .. ... |.|| ||  .|  |       . ..... .  .. |. ....   || |||| | 
aepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae...PllvHcsaGv

DRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
.|. ...|. | |. |  .| ||. |  ..|| .|. |..   |||||..|...| .
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 902-1155 9.5e-45 147.6 In-house 32-285 (305) alignment
Range on Protein: 902-1155
Range on HMM: 32-285/305.0
NRFSDRTtKNSDLK--ENACKNRYPDIKAYDQTRVKLaviNGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNK
.|| |   |   .|  ..| |||| |.   |. ||||   .|    .|| ||.|    . |.|||.| |.| |  ||| | .....| | || || |   
krfndfe.kmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekga

AKCAKYWPEKVFDTKQFG----DILVKFAQERKTGDYIERTLNVSKNKANV-GEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvyslQRGPIL
 ||..|.. |  |. .|      | |||    .     .   .|.. .  . |  |. |..|.||.  | |   |     |.... .  .     .||| 
kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp....skgpiv

VHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNT-VCDLRHQRNFLVQSLKQYIFLYRALLD
||||||.||||..| |. ...|| . . .   .  .  .| |||  .|. .||.|... .|.
vhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 888-1155 1.2e-43 144.1 In-house 3-257 (267) alignment
Range on Protein: 888-1155
Range on HMM: 3-257/267.0
DTDYGFLREYEMLpNRFSDRTTK--NSDLKENACKNRYPDIKAYDQTRVKLAVinglQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHL
| .  . .|.|.. .. || ...   |  ..|. .||. |   ||.||| |      .. .|||| .| ||| ...||  |.|.. || ||. .| .|..
deeceiekefeli.kkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkv

EIIVMLTNLEEYNkakCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVsKNKanvgeEEDRRQITQYHYLTWKdFMAPEHPHgiIKFIRQINSV
 .||.||.  . |     ..|| |. ..|.. |. |... |..  ||   ||.. | |     .|  ...| |.|  |.   . ..|.  .| .  | . 
pvivlltkvftdn...irlfwPPkmgqakkyqdltvehslekeendyqiitlel.kfk.....nesahnvtlyyykkwn.intnnkpy..lkplfgilak

YSLQRG--PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
  |. |  |..|.||.||||.||.. .|| .... .|. . |.. .  .|.||  ||... .||.... | .
nqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1196-1455 1.3e-43 143.8 In-house 23-297 (301) alignment
Range on Protein: 1196-1455
Range on HMM: 23-297/301.0
ATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPM--RENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG
.  .. .|||.|| .|||.. || ..| .|| ||.||.| |     . .|||||.|.|| ... ||.||.|...|. ||||.| .. ....||. .  .|
elkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkeg

-PRKCPRYWADDEV---QYDHILVKYVHSESCPYYTRREFYVT-----------------NCKidDTLKVTQFQYNGWPTvDGEVPEVcRGIIELVDQAY
   || .|| . |    .. .. |. |..   | .. |.. |.                 . |  .. .|.|.|   ||. || |.|  | ... .|.  
tkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpq.dGvvrep.rtvLqviddvi

nhYKNNKNSGcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLHH
  ....| .|  .|. |||| .  || ..... | .   . |  ||.   |. .| .. | .    || ... .|  |  |..
..hrqqkigg..gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns

0046846 (Phosphotyrosine protein) phosphatases II 945-1153 1.5e-42 140.6 In-house 12-169 (176) alignment
Range on Protein: 945-1153
Range on HMM: 12-169/176.0
TDYINANFVIGYkerkKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvfdTKQ--Fgdilvkfaqerktgdyiertlnvskn
 ||||||...|.    ..|. |||...|. ||..|..|.. ...|.||.. |... ||. ||||     ..  .                          
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..........................

kanvgeeedrrqitQYHYLTWKDFMAPEHpHGIIKFIRQINSVYSLQrGPILVHCSAGVGRTGTLVALDsliqQLEEEDSVSIYNTVCDLRHQRN-FLVQ
              ||..| | |. .|..   .......|.....   ||.|||||||.||||||||..     || |  .|...... .| ||  . ||
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

SLKQYIFLYRAL
. .|| |||...
tpeQyrflyefe

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 892-1158 1.6e-42 140.1 In-house 12-270 (281) alignment
Range on Protein: 892-1158
Range on HMM: 12-270/281.0
GFLREYEMLPNR-FSDRTTKNsDLKENACKNRYPDIKAYDQTRVKLAV-INGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIV
 | .|.  ||    ||  |   .   |  |||| .| . | .||.| | .   ..|||| ||..     .. .| .||| . |  |||||||..    ||
dfkqefsnlpgdppsdlctvf.nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERktgdyIERTLNVskNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvyslQ
|| .. | |. |||.|.| .     ||  . |.. .       ....|     . |.  | . | ||.. .  | |.  ||    ..| .|.| .    .
mlcqfletnrekcaeyfprnahcclqfdklsvsyedst.....vnkslvt..trlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....r

RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSV-SIYNTVCDLRH-QRNFLVQSLKQYIFLYRALLDTGT
  | ..||||||||.|||.|..  .| .    ..  | . |  ||   |   ||.|.||..... ||| | 
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1188-1449 4.3e-42 139.1 In-house 23-277 (439) alignment
Range on Protein: 1188-1449
Range on HMM: 23-277/439.0
EVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMI
. .|||. .|  . .  .|.  .| .. ||| ... ..|  ||.|  .|    | |||| .|.|| . . .| .| | ..|  ||||.. |. ..|.||.
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

SEIGDGPRkcprYW-ADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKiDDT---LKVTQFQYNGWPtvDGEVPEVCRGIIELVdQAYNHYKNNKNSGc
... .  .    || .|.|| |  | |.  .    | |. | | | | . | |     | ||.|  ||  | .||  .  ..... .| |  ..... | 
tnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfner.dttekertvlqfhyiawp..dknvpaqashvldfl.rainsandkeeyg.

rsPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
  |. |||| |  |.   .|. | ...|.||. |||    . || ||. .... .|| |.. |...
..pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_ptpA1_pd Subfamily ptpA1 894-1117 1.3e-41 137.7 In-house 24-256 (418) alignment
Range on Protein: 894-1117
Range on HMM: 24-256/418.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKeRKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
  |. .| .      | . | | |. |||| .|   ..|||.|  |.  . .||||||.. |    |.|||.|||.  || |||||.||..  |||||. 
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsr

LEEYNKAKCAKYWPEKVFdTKQFG------DILVKFAQERK-TGDYIERTLnvSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQI----
  |  . || .||||..   .||       ...  .. |     .  || .     .  .  | . |.||||.|  | |.  |.| . . .... |    
esencrikcdrywpeqig.geqfsiygngnevfgtysvelveviqdperei..itrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

-NSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQL
 . . | .|  ||.||||||||||||...   ....|
nqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_PTPN13_pd Subfamily PTPN13 1202-1449 1.5e-41 137.5 In-house 26-267 (273) alignment
Range on Protein: 1202-1449
Range on HMM: 26-267/273.0
SKSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmrENSTYINASFIEGYDN--SETFIIAQDPLENTIGDFWRMISEQSVTTLVMI-SEIGDGPRKCP
 ..|.||...||. ||| ....|||. ||.|      ....|||||.|.   .    ..|..| || .|. |||.|. ||... ..|. .|  .|  || 
ldtcevgkkkenkdknryrnvlPydetrvklg.....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

RYWADDEVQ----YDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAyNHYKNnknsgCRSPLTVHCSLG
||| . . .    .. . |. .. .    .. |.. |.. .  .. .|.....  ||  | .||     ....| .  .. ..      ..|. |||| |
rywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwP..dhgvPssaaellqfvaev.rrlqt.....dagPivvhcsaG

TDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
  || ..... .... .  .| .|.  . |||| || |.. .  || | ..||..
iGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 914-1155 1.8e-41 136.7 In-house 52-287 (305) alignment
Range on Protein: 914-1155
Range on HMM: 52-287/305.0
LKENACKNRYPDIKAYDQTRVKLAVINglqTTDYINANFVIG-YKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFD
 . .  |||| |. . ||. |||.  .    .||| ||.|       |.|||||||.. |||.|| |. ....| |||| .  |  | |||.|||    .
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

TKQFGD-ILVKFAQERKtgdYIERTLNVSKNKANVGEEEDRRqiTQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALD
 ...   |.|.     |    .||  ..     |.    |..      .| | ..     |   .  .  . ..    . ||.||||||.|||||.||..
klelksgivvenvsgsk...pmerdaeiqitllnltysgdqk..msvrhlqwtewpdrgvppckltslellsairg.skvpivvhcsagigrtgtivaie

SLIQQLEEEDS-VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
 ..... |. .   . . |  || || | .|.  ||.|..| .|.
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

0043147 (Phosphotyrosine protein) phosphatases II 944-1150 3.8e-41 136.0 In-house 4-154 (172) alignment
Range on Protein: 944-1150
Range on HMM: 4-154/172.0
TTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLeeynkakcakywpekvfdtkqfgdilvkfaqerktgdyiertlnvsknk
 .|||||... .|   ..||. |||. .|..|||||..|..  .||.||.|                                                 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

aNVGEEEDRRQITQYHYLTWKDFMAPeHPHGIIKFIRQINS-VYSLQRGPILVHCSAGVGRTGTLVALDSLIqqleeeDSVSIYNTVCDLRHQRNFLVQS
  .  |   |.. ||.|| | |. .| ..  ...|...|.. .   . ||.||||||||||||||||.. ..       ..|....|. .|..|.  ||.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

LKQYIFLY
  ||.|||
psqyrfly

0049260 (Phosphotyrosine protein) phosphatases II 954-1150 4e-40 132.3 In-house 3-143 (152) alignment
Range on Protein: 954-1150
Range on HMM: 3-143/152.0
IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWpekvfdtkqfgdilvkfaqerktgdyiertlnvsknkanvgeeedrr
 ||.  ..||..|||.. |..|||||..|..  .|||||.|.| .| ||..|.                                               
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................

qitQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIqqleeeDSVSIYNTVCDLRHQRNFLVQSLKQYIFLY
   ||..| | |. .|...  .. ... |.  .  . ||.||||||||||||||||.. ..        ||....|  .| .|.  |..  |..|||
...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_PTPN1_pd Subfamily PTPN1 1193-1451 1e-39 131.0 In-house 10-271 (290) alignment
Range on Protein: 1193-1451
Range on HMM: 10-271/290.0
KLLATADEISK--SCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEI
... . .. ..  .... ...||. .|| ... |||  |..|     |..  |||||..|  .    .|..| || ||.. ||.|. ||   ..||. ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

-GDGPRKCPRYWA----DDEVQYD--HILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKNSGc
   .  || .||     ..|....  .. ||... |.  |||.| . ..| | ..| ....| |  ||  |  |||     .... .  .    ... | 
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwp..dfgvpespaaflkflfkvresGslssdvG.

rsPLTVHCSLGTDRSSIFVA-MCILVQHLRLEK--CVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
  |  .||| |  ||  |.   ..||.  . ..  .|||  .  .||..|.|||    | .| . ||.. .
..pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1182-1452 1.6e-38 127.2 In-house 3-260 (267) alignment
Range on Protein: 1182-1452
Range on HMM: 3-260/267.0
EGKCKLEVEFEKLLATADEISK-SCSVGenEENNMKNRSQEIIPYDRNRVILTplpMRENStYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQS
. .|..| |||..   .|. |. |.|..  |.|. .|| .. .||| .||||     .|.  |||||..|||   ..||. ||||.|||.||. .| .| 
deeceiekefelikkisdtsstisqsia..eknqernrlddnlpyddtrvilr...tkeee.yinasyvegyktknafivtqdplkntitdfltvihdqk

VTTLVMISEIGDGprKCPRYWADD---EVQYDHILVKYVHSESCPYYTRREFyVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVcRGIIELVdqAynhyKN
|.. |..  .. .  . ...|        .|. . |..   .    |    .   . | . . .|| . |. |     . | . . .. ..  |    ||
vpvivlltkvftd..nirlfwPPkmgqakkyqdltvehslekeendyqiitl.elkfknesahnvtlyyykkwnintnnkpyl.kplfgil..a....kn

NKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
. . |   || |.|| |  ||  |. .   .. .. |  .||    ||.|||| ||...  .| ..|. . .|..
qleng.nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

0044763 (Phosphotyrosine protein) phosphatases II 929-1152 3e-38 126.6 In-house 2-166 (178) alignment
Range on Protein: 929-1152
Range on HMM: 2-166/178.0
YDQTRVKLAVINGLQTTDYINANFVIGYkerkKFICAQGPmestiDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFdtkqfgdilvkfaqerk
.| |||.|  . ||...|||||......     ......|      |......|...  ||.||.  |... || .||||.                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tgdyiertlnvsknkanvgeeedrrqiTQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQleeedSVSIYNT
                            ||... . |. .|. .  . .|.. |..... . ||.||||||||||.|||||.. ....     ..|... 
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleea

VCDLRHQRNfLVQSLKQYIFLYRA
.  .| .|.  |..  |. .||. 
ielvrerRp.ivpnpgqlrqLyef

0051429 (Phosphotyrosine protein) phosphatases II 1240-1451 2.2e-37 124.5 In-house 3-225 (272) alignment
Range on Protein: 1240-1451
Range on HMM: 3-225/272.0
NSTYINASFIEGYDN---SETFIIAQDPLENTIGDFWRMiSEQSVTTLVMISEIGDGP-RKCPRYWA-------------DDEVQYDHILVKYVHSESCP
 |.||||... || .     ... .. ||..|. ||||.  |. ..| |.. .    .  ||.|||.             . .. | .. |.... | ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

YYTRREFYVTNC-KIDDTLKVTQFQYNGWPTVDGEVpEVCRGIIELVDQaynhyknnknsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVD---
.|. ||...|.. . .....|....| .||.      | .. ..||. .               |. |||| | ||. ..||. .|.. . ||  ||   
dyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld.............ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----ICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
     . .. ..||.|| | . ...||.||..|.... 
ltnlyleeaveelraqrpgavqteeqylflyeallell

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 912-1085 4.6e-37 122.5 In-house 26-196 (297) alignment
Range on Protein: 912-1085
Range on HMM: 26-196/297.0
SDLKENAC--KNRYPDIKAYDQTRVKLAviNGLQTTDYINANFVIGYKERK--KFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
|  | |..  |||| || |.|.|||||   ..   .|||||..|.  .| .  |.|.||||...|.||||....|| . .|||...|.|  . ||| |||
ssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

EKVFDTKQFGDILVKFAQERkTGDYiERtLNVskNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV
. | . .. ||..|.|  .  . .. .| . .   . ..   ...|...   .|.| |   |   . . .|  |. |.
svvqerlkagdvvveflsst.sdef.dr.vil..telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 892-1164 1.1e-36 121.0 In-house 28-296 (310) alignment
Range on Protein: 892-1164
Range on HMM: 28-296/310.0
GFLREYEMLPNRFsDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAvINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVML
|. ..|  |  .  | .      |..  |||| |.   |..||||  |.  .  ||| ||.|     |. |||.|||.. || ||||||...  | |..|
glvkqyrkldakq.dssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TNLEEYNKAKCAKYWPEkVFDTKQFGDILVKFAQERKtGDYIERTLNVSKNKANVGEEEDRRQITQ--YHYLTWKDFMAPEHPHGIIKFIRQiNSVYSLQ
 .  |  . ||  |||  .  |. .| | |    |    ..    | |.    ||  .|.  .. .     . | ..     |    . . |   .  ..
ckvgeegrpkcvgywps.lgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rllaqvr

RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTgTFGNTDI
 || .||||||..|....|||.  |..|.. . | . . . .|...|   .|.  ||... |  .   . |.|..
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif.argetev

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 916-1154 1.6e-36 120.8 In-house 46-341 (350) alignment
Range on Protein: 916-1154
Range on HMM: 46-341/350.0
ENACKNRYPDIKAYDQTRVKLA--------VINGLQTTDYINANFVIG----YKERKKF--ICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAK
|   |||| .|  |...||||         .   |.| ||||||..       .   .|  | .|.|. ||.|||...| . . ..|..||.. |.|  |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAKYWPEKVFDTKQFgDILVKFAQERKTGD----------------YIERTLNVSKNKANVG---EEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIR--
| .||.|  .| ..   .  |  .   . |                 |.   .. .|. ..       |   . | ..  |||     .|. |.. .   
cyrYWqegsydditv.klaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevk

-----Q-INSVYS--LQRGPILVHCSAGVGRTGTLVALDSLIQ---QLE--EEDS----------VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
     . .   ..   .  |||||||||||||||||.||||..    ||  ...|            |  .|  ||.||  .||.|.|.||.| |||
ndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_egg_pd Subfamily egg 893-1154 2.9e-36 119.7 In-house 16-267 (307) alignment
Range on Protein: 893-1154
Range on HMM: 16-267/307.0
FLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLT
. | .|.| .   . . ...  ..|  | | . ..  | .|||| . .|  . |.| || | |     .||.|| |.  | ||||||..... . |||||
lerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlt

NLEEYnkAKCAKYWPEKVFDTKQF--GDILVKFAQERKTGDYIertLNVSKNKAnVGEEEDRRQITQYHYlTWKDFMAPEHPHGIIKFIRQINSvyslqr
   |    .|  |||    |. ..  | . ..  .  .. | .   ..|.| |  || ... | .  . .  ..       |  ... .|..        
srkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklkl.vGgddeerflehwqg.dvnnssdvysplrvlrklrnlsk......

gPILVHCSAGVGRTGTLVALDSLIQQLEEE--DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
 |..|..  || ...||||..  . .|         . ..|  || .|.. |.|  .|.|.|| .|
.pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

0051082 (Phosphotyrosine protein) phosphatases II 945-1153 4.4e-36 119.1 In-house 3-149 (151) alignment
Range on Protein: 945-1153
Range on HMM: 3-149/151.0
TDYINANFVIGYkerkkFICAQGPMEstidDFWRMIWEQHLEIIVMLTNLEEYNkaKCAKYWPEKVfdtkqfgdilvkfaqerktgdyiertlnvsknka
.||||...| |.     ... .||..    ||.....|...  ||.|...||..  .|..|.||                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

nvgeeedrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvysLQRGPILVHCSAGVGRTGTLVALDSLIQQleeedsVSIYNTVCDLRHQRNFLVQSLK
        ........| |.|.  |.... ...|......    . ||.|||||||.|||||||||. ....      ||.. .. ..| .|  .||.  
........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

QYIFLYRAL
|..|...||
qflfqlfal

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1204-1449 6.8e-36 118.5 In-house 36-234 (392) alignment
Range on Protein: 1204-1449
Range on HMM: 36-234/392.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPrkcprywad
  .|...| |  ||| ..|.|||..||.|  .    .| |.|||.|...|| ...| .| |   .. |||||. .. |||..|.... .|          
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

devqydhilvkyvhsescpyytrrefyvtncKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnknsGCR-SPLTVHCSLGTDRSSIFV
                               | ||.  |.||..  ||  | .||.    ..... .   ..      |    || .||| |  |. . .
...............................kgddartvaqfhftewP..dkdvpkhtssllkfikevkadf......Gqythpliihcsagvgrtgvvi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
..  .| | .  . ||.     ..| .|  ....  || |.. |...
sidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 915-1155 2e-35 117.1 In-house 33-268 (285) alignment
Range on Protein: 915-1155
Range on HMM: 33-268/285.0
KENACKNRYPDIKAYDQTRVKLAVinglQTTDYINANFV-IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDT
. |   ||| |... ..||| |      .  ||| |... .  |..  .| .|||.  |. |||.||.....  ..||  | |    ||| |.|||. . 
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

KQFGDILVKFA--QERKTGDYIERTLNVSKNKANVGEeEdrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALD
 .||   . ..  .|      |  .| | . .    |      . . .   | | .|||  . .|.. . .. |   .  || |||||||||| |.| .|
vkfgkyeitlteckeeaiagtilnaltvintedasse.p..lymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgid

SLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
    .. |.  . . . | ..|  |   |||  |..|||  |..
yatirimenpniemldivremramrfqavqshmqflflyvvlme

PTPc_DSPc_SM00012 1055-1154 2.3e-35 116.3 In-house 2-104 (105) alignment
Range on Protein: 1055-1154
Range on HMM: 2-104/105.0
ITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR--GPILVHCSAGVGRTGTLVALDSLIQQLEEE-DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
...|||..|.|. .||... |....|....... .   .|..||||||||||||.|||| |.||||.| ..|.|...|. ||.||. .||.. ||.||||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALL
|||
all

0049772 (Phosphotyrosine protein) phosphatases II 1202-1452 1.4e-34 115.6 In-house 35-281 (314) alignment
Range on Protein: 1202-1452
Range on HMM: 35-281/314.0
SKSCSVGENEENNMKNRSQEIIPYDrNRVILTPLPMREnSTYINASFIEGYdnsETFIIAQDPLENTIGDF----------WRMI--SEQSVTTLVM---
.... |.  ..|  |||...|.|.| |||||  ||..  | |||||.. |.    .||..| |||.|. ||          |||.  ... | ..||   
eltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ISEIGDGPrkcprywaddevqydhilvK----------YvhsescpyytrrefyvtnCKIDDTL--KVTQFQYNGWPTVDGE
                  . ..  ..                                                   ..|    . . ..|  .|. ||.
evladelsrLdaAlgKtpllildgng...................neptaadlellk..................eelydpelferlgikylripvpDgs

VPevcrgIIELVDQAYNHYKNNknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLrlekCVDICATTRKLRSQRT-----GLINSYAQYEFLHRAIINYS
.|     ..| .|..... ...      .|. |||. | .|.  ||....|. .|     |..  . . .|..|.     |.|... |||| ..|. .| 
ap.....lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleyl

D
.
k

0041856 (Phosphotyrosine protein) phosphatases II 1213-1450 5.7e-34 112.7 In-house 1-170 (182) alignment
Range on Protein: 1213-1450
Range on HMM: 1-170/182.0
NNMKNRSQEIIPYDRNRviltplpmreNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISeigdgprkCPRYWADDEvqydhil
|  ||| ..|.|||..|          ...||||... |.  . .||..| || .|. ||.||. |. .||.|...        ...||....       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

vkyvhsescpyytrrefyvtnckiddtlKVTQFQYNGWPTVDGEVPEvCRGIIELVDQAYNhyknnknsgCRSPLTVHCSLGTDRSSIFVAMCILVQHlr
                            . . .||  .|  |..||.  . ..........            |  |||| | .|.  .||. .. ..  
............................erlgiqylylpwpDhgvpd.ldelldfieevle.........eggpvlVHCsaGvgRtgtlvaaylmkkl..

lekCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
    |..  . . .||.| | . .  || ||..|.  .
...gvsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1212-1448 5.3e-33 109.2 In-house 2-236 (237) alignment
Range on Protein: 1212-1448
Range on HMM: 2-236/237.0
ENNMKNRSQEIIPYDRNRVILTPlpMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWAD--DEVQ
||..|||  .|. || .||.|       .| ||||....|.| .  ..| || |||..  |||.|. ..  . .||.. . .|   || .|| .  .   
enkiknrygnivaydhsrvvlkg..agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YDHILVKYVHSESCPYYTRREFYVTNCKIDDTLK-VTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKNSGcrsPLTVHCSLGTDRSSIFVAMCI
|  . |   . |    || | . ...      .. . |.|.  ||  |  ||. .  .. .  .  |. .   .||   |  .||| |  |. ||. .  
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswp..drgvpqqtaallrfrkniinrsphvsesg...pwiihcsagvgrtgiflvida

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
.... . .| |||      .  .|  .|..  || |.|..|.
mlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1213-1448 2.8e-32 106.8 In-house 7-237 (239) alignment
Range on Protein: 1213-1448
Range on HMM: 7-237/239.0
NNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSE-TFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADDEVQYDH
|. |||  .|. ||..||.|  |     | |||||..  || |  ..| .|  .| . ||||||. ..    .||.. . .|  .|| .|| |   .|  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

ILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNSGCRsPLTVHCSLGTDRSSIFVAMCILVQH
. |   ..|    |  | | ...    .   | |...  ||  |  ||. .  .. |  .      ..   |.| |  .||| |  |.  |. .  ....
lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp..dkgvpqyatavlglrrki....tkdslpgar.pwvihcsagvgrtgaflvidamlrq

LRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
 . .| |||    . .| .|  ....  || |.| |..
akkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1212-1448 3.1e-32 106.7 In-house 7-238 (239) alignment
Range on Protein: 1212-1448
Range on HMM: 7-238/239.0
ENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSE-TFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADDEVQYD
 |. |||  .|. ||..||.|  |     | |||||..  || |  ..| .|  .| . ||||||. ..    .||.. . .|  .|| .|| |   .| 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

HILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNSGCRsPLTVHCSLGTDRSSIFVAMCILVQ
 . |   ..|    |  | | ...    .   | |...  ||  |  ||. .  .. |  .      ..   |.| |  .||| |  |.  |. .  ...
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp..dkgvpqyatavlglrrki....tkdslpgar.pwvihcsagvgrtgaflvidamlr

HLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
. . .| |||    . .| .|  ....  || |.| |..
qakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 919-1147 6.3e-32 105.5 In-house 52-271 (301) alignment
Range on Protein: 919-1147
Range on HMM: 52-271/301.0
CKNRYPDIKAYDQTRVKLaVINGLQTTdyINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGD
 |.||| .    .| |.. . .| .    | ||..    . ..||..|||...| .||| |.   ..| ||||..  |... ||..| | |. .. . | 
dkhryptvPckPstavev.ivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

ILVKFAQERK--TGDYIERTLNVSKNKanvgEEEDRRQITQYHYLTWKDFMAPEHPhgiIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALDSLIQQ
  .|  .. .    . ..|||.|        .. . | .| | | .| |   |.     ..    .. |    . ||.||||||.||. .... . | ..
fkikiknkelilnkkiskrtlevedst....gkfatrtvthyqysewtdrgvPksh...aelfdlmelvkk.sekPivvhcsaGiGrsvafigteylare

LEEEDSVSIYNTVCDLRHQRNFLVQSLKQYI
.| .  . . ... .||..|   ||  .|  
veadptieltealkhlrehrwngvqtnsqly

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 894-1155 8.5e-31 101.8 In-house 22-274 (312) alignment
Range on Protein: 894-1155
Range on HMM: 22-274/312.0
LREYEMLPNRFSDRTTKnSDLKENaCKNRYPDIKAYDQTRVKLAVinglQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
 .||  . | .||     . || .   ||||.|. .|. |  ||     .   || ||||      ..|.|.|||.|.|.  ||..        |..|. 
tkeykavgnivsdsect.aflkfk.dlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

LEEYNKAKCAKYWPEKVF-----DTKQFGDILVKFAQERKTGDYIertlNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIrqinSVYSL
. |    |||||  . |      | . . .   .     |. | |         |  |    .  .. .| . .| |   |.      ...    |    
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdki....thrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll....savkk

QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
.. |.. ||||||||||||. ..|.|  |       . ..   ||..|   |. . ||..  |..|.
dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1188-1448 9.9e-30 98.4 In-house 10-292 (297) alignment
Range on Protein: 1188-1448
Range on HMM: 10-292/297.0
EVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPmrENSTYINASFIEGYDNSE--TFIIAQDPLENTIGDFWRMISEQSVTTLV
| | . ||  |   ..| |.   .    ||| ..|. .| .|| |   .   .. |||| ..   |. .   .|.|| ||..|. |||... || | ..|
eaekdllldear..gesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrviv

MISEIG-DGPRKCPRYWAD---DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVP----EVCRG-------------I
|....  ||  ||  || .   .  .  ...|... | |  . .     ..    ... .|.  |. .||  |  ||    .. |              .
mvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswp..dhGvpsdledlvrfqaqvcscciavpmm

IELVD----QAYNHYKNNKNSGCR-SPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
. ||.      .   .  .    |  .| |||| |  || . |   .... || ..  |. |  ..||.||. |...  |.|.|. |..
lalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

0046846 (Phosphotyrosine protein) phosphatases II 1232-1450 1.1e-29 98.8 In-house 3-172 (176) alignment
Range on Protein: 1232-1450
Range on HMM: 3-172/176.0
LTPLPMRENSTYINASFIEGYdnseTFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADdEVQYDHilvkyvhsescpyytrrefy
|..|  .....||||..| |.     .|. | ||..|. ||..|. |. .|..|.. |  .  | |||.|| . . ....                    
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi....................

vtnckiddtlkvtqfQYNGWPTVDGEVPEVcRGIIELVDQAYNHYKNNknsgcrSPLTVHCSLGTDRSSIFVAmCILVQHlrlEKCVDICATTRKLRSQR
               ||  .|..|. ||.  . ..||... ....|..       |  |||| |  |.  .|| . |...   ||....  . ...|.||
...............qylhlpwpDhgvpdl.elllellefirealkeg......gpvlVHCsaGigRtgtlva.ayllel...ekglsveealalvreqR

T-GLINSYAQYEFLHRAIINY
  | . . .||.||....  .
plgavqtpeQyrflyefelll

0036282 (Phosphotyrosine protein) phosphatases II 1241-1444 3.9e-29 97.0 In-house 2-163 (174) alignment
Range on Protein: 1241-1444
Range on HMM: 2-163/174.0
STYINASFIEGYDNSETFIIAQDPLEntigdFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADdevqydhilvkyvhsescpyytrrefyvtnckIDDT
|.|||||.. ..  .. .|. | ||.     ||.|. |...||.||  |       ||..|| .                                  . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

LKVTQFQYNGWPTVDGEVPEVCRgIIELVDQAYNHYKNnknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRlEKCVDICATTRKLRSQRTGLINSYAQ
|. . .||  .|..|..||..   ..|.|.........    .   |. |||| | .|. ..||. .. ..|. |. ||.... |.||.|| | . .  |
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YEFLH
|.||.
yrfly

0043147 (Phosphotyrosine protein) phosphatases II 1239-1444 2.4e-28 94.4 In-house 3-154 (172) alignment
Range on Protein: 1239-1444
Range on HMM: 3-154/172.0
ENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIgdgprkcprywaddevqydhilvkyvhsescpyytrrefyvtnCKIDD
|.|.|||||....|     ||. | || ||. |||||. |. .|..|.. |                                            ... .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

TLKVTQFQYNGWPTVDGEVPeVCRGIIELVDQAYNHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVqhlrleKCVDICATTRKLRSQRTGLINSYA
 |. . .||  .|  |. ||   . ..|.... .... ....     |  |||| | .|.  .||. ..       .....  . . .|..| | . .  
llerlgiqylylpwpDhgvp.llellleflefidellalspg....gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYEFLH
|| ||.
qyrfly

subfamily_CG42327_pd Subfamily CG42327 918-1088 2.6e-28 93.6 In-house 27-199 (319) alignment
Range on Protein: 918-1088
Range on HMM: 27-199/319.0
AC--KNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKER-KKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKV--FD
..  |.|. ..    .||| |  |   . . |..|..| ||..    .|.|| ..|..  ||||..|||   .|| ||.| |    .||.|.| |    .
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TKQFGDILVKFAQERKTGDYIERTLNVSKnkanVgEEEDRRQITQYHYlTWKDFMAPEHPHGIIKFIRQINSV---YSL
|. .||||| . .      |.  || . .    | ..|  |..| | |  | .   | ..  .|  . ...|    |||
tslyGdilvtlkgrevkdryaistlllkr....v.dkeesrelthywy.kwleaevPaeeaaliamllevrsslksysl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1179-1450 1.4e-27 91.5 In-house 10-276 (307) alignment
Range on Protein: 1179-1450
Range on HMM: 10-276/307.0
KPNEGKCKLEVEFEKLlatADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISE
  . |  .|  ||..|   |.   .. .|   . |. ||| |..   |..|....       | || | ..    .   || || |||||. .|| |. .
tldkgvqalvdefrvl...akktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiq

QSVTTLVMISEIG-DGPRKCPRYWADDEVQYdHILVKYVHSESCPYYTR-------REFYVTNCKID---DTLKVTQFQYNGWPtvDGEVPEVCRGIIEL
. | ...|. ..   .  || .||  .| |   . ..  .. |                 ||. |.|   ..  ....|.. ||  |  ||..  . |.|
ekvesvimlckvielakikceqywpleegqk.lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwp..drgvpqinltainl

VDQAyNhYKNNknsgcrsPLTVHCSLGTDRSSIFVAMCILVQ-HLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
..   . |..|       |. |||| |  ||   ||.... .  .. . | |.    ..|||||   |.. ||| .||| ...|
leav.r.ydtn.......pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1187-1455 1.4e-27 91.2 In-house 24-291 (305) alignment
Range on Protein: 1187-1455
Range on HMM: 24-291/305.0
LEVEFEKLLAtADEISKSCSVGENEEnNMKNRSQEIIPYDRNRVILTPLPMrenSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVM
|  ||  .    ... |  .  | .| . ||| ...   |.||| | .        || | ..    |.. || .| |||.|  ||| |  .. | .. |
lraefvamkr.fndfekmkafkeaqe.agknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifm

ISEI-GDGPRKCPRYWAD---DEVQY----DHILVKYVHSESCPYYTRREFYVTNCKI------DDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAy
. ..   | .||  |.|    |....    ..| ||.  |..  . .  .  ||. ..       ...|||.. .. ||  |  ||     |.||. .| 
lcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwp..drgvpaadlailelleka.

nhyknnknSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRL-EKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLHH
           . |..|||| |  |.   | .  ... |   ..  |     .|.| ||   |.. ||| |.|. |.||   ..
........rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkk

subfamily_ptpA1_pd Subfamily ptpA1 1181-1411 4.6e-27 89.8 In-house 15-256 (418) alignment
Range on Protein: 1181-1411
Range on HMM: 15-256/418.0
NEGKCKLE--VEFeKLLATADEiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDnSETFIIAQDPLENTIGDFWRMISE
|  ||  .   || .||  .       | |... |  |||  .|.| .. || |  .  .| | |||| .|.|    . || .| || ||| |||||. |
nhikcihkikeef.rlleesvg.psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwe

QSVTTLVMISEIGDGPR-KCPRYWADDEV--QY------DHILVKY-VHSESCPYYTRREFYVTNCKI---DDTLKVTQFQYNGWPtvDGEVPEVCRGII
. .  .||.|   .  | || ||| ..    |.      . ..  | |          ||    | ..    .|  .||.||.|||  | ..|.  . . 
nrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwp..dhnipdhtqpfr

ELVDQAYNHYKNNKNSGC-RSPLTVHCSLGTDRSSIFVAMCILVQHL
.|.    |. ..   |     |. |||| |  |.  |..  |....|
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 909-1150 4.8e-27 89.8 In-house 10-252 (290) alignment
Range on Protein: 909-1150
Range on HMM: 10-252/290.0
TKNSD-LKENACKNRYpDIKAYDQTRVKLAVINGLQTTDYINANFVIgYKERKKFICAQGPM-------ESTIDDFWRMIWEQHLEIIVMLTNLEEYNKA
....| .|... ..|. ..    .||| | .     . ||| ||.|. . .  ..|  | |        .||| .|| |. . . . .||| . || .. 
llktdyvkkhemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksan

----KCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINsvysLQRGPILVH
     |||| ||.| .  .|... ||  .  |  | ..|.| |  ..      |   ..| . .  |..  ..|..  ... |....     .. |..||
tslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd......eeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivH

CSAGVGRTGTLVALDSLIQQLE-EEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLY
|  |. |  .| |..   | .   ..||.. . . .||.||. ...| ... |  
cvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

PTPc_DSPc_SM00012 1341-1448 9e-26 85.5 In-house 1-104 (105) alignment
Range on Protein: 1341-1448
Range on HMM: 1-104/105.0
KVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNNKNsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLE-KCVDICATTRKLRSQRTGLINSYAQ
.|....|.|||    .||| .  |.||...  ........   ..|. |||| | .|. .|||..||.|.|. | |.|||. . ..||.|| |......|
tvkhyhytgwpdh..gvPeesdsilellravkknknkses...skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq

YEFLHRAII
| ||.||..
ylflyrall

0048076 (Phosphotyrosine protein) phosphatases II 1005-1153 1.2e-25 85.3 In-house 2-139 (145) alignment
Range on Protein: 1005-1153
Range on HMM: 2-139/145.0
YWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVsknkaNVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQrGPILVHCSAGVGRT
||| ....   .|.. .    |.     | . ||.        .|   |...||.|| | |. .|. .  ...|...|.....   ||.|||||||||||
ywpseilpglylgslptaldlellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRt

GTLVALDSLIQqleeeDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
|||||.. ...      .||.....  .| || . |..  |..|||...
gtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 916-1155 2.6e-25 83.5 In-house 47-342 (349) alignment
Range on Protein: 916-1155
Range on HMM: 47-342/349.0
ENACKNRYPDIKAYDQTRVKLA-------VIN-------GLQTTDYINANFVI--GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNK
|  .|||| ||  |. .||||        ||.       . .  ||||||..    ..  ||.|. | |. ||.|||...|  . ..... |.. .| . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

AKCAKYWPEKVFDTKQF------------GDILVKFAQERKTG---DYIERTLNVSKNKANVGEEEDRR---QITQYHYLTWKDFMAPEHPHGIIKFIR-
 || .|| |  .. ..                 ... ....|    | ...  .  ..  .     . .   .. |  .  | |      |  |.. .  
ekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalev

------QINSVYS---LQRGPILVHCSAGVGRTGTLVALDSLIQ--QLEEEDSVS----------IYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
      . ..       |  ..||||||| ||||.|| ||.|..  .  ...|.           |. .|  || ||  .|| |.|.|..| ||| 
kndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 911-1154 3e-25 83.2 In-house 45-282 (302) alignment
Range on Protein: 911-1154
Range on HMM: 45-282/302.0
NSDLKENACKNRYPDIKAYDQTRVKLAVinglQTTDYINANFVIGYKERKKFICAQGPMESTI---DDFWRMIWEQHLEIIVMLTNLEEYNKaKCAKYWP
 .  |.|  ||. .|....|...|||.     .  .|.||  |   . ... | || |  ..    ..||||.....   .|.|   || .|    ...|
Ckafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfp

EKVFDTKQFGDILVKFAQERKTGDYI-ERTLNVSKNKANvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGT
.|  | |..|.. |   .  |. .   . .. |  .        .   .. |.   ||.   |..   .|| . ..    .    ....    |.|| |.
kksgdykeygkmfvNnrkVekaeeektryviEvlPegcs.....nsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRaga

LVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...|   ...|.... . | ..|  .| ||   |.|||||..||.|||
fltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1212-1451 3.5e-25 83.2 In-house 55-283 (290) alignment
Range on Protein: 1212-1451
Range on HMM: 55-283/290.0
ENNMKNRSQEIIPYDRNRVILTPlpmRENSTYINASFIEGYDNseTFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPRYWADDEVQ---
 .  ||| ....  |. ||||       .  |. | ...| .   .||..| .|..|. |.|||. .. |...||. | | ||  || .|. . | .   
tefkknrykdvvcndktrvilkd...GydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YDHILVKYVHSESCP-YYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVdqaynhYKNNKNSGcrsPLTVHCSLGTDRSSIFVAMCI
. .| |    ...      .. . | . .     |.  ..   ||  |  |.     .. ..      .   | ||   |..|||| |  |.  |||. .
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp..dksvalstlallrtl......rilrkasG...pvvvhcsaGiGrtGtfvaiev

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
 .| |   | .|.  . | ||  | . ..   ||  | ...... 
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 957-1151 4.3e-25 83.0 In-house 2-198 (199) alignment
Range on Protein: 957-1151
Range on HMM: 2-198/199.0
KERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeEEDRRQIT
| ....|..| |.  |. |||.|.||     |||. . .  ..|  . |||     | ..| . |         ||   .| ...| .        |.|.
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta...ppstreis

QYHYLTWKDFMAPEHP--HGIIKFIRQINSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQLEEED--SVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
.| . .||.  .|.     |..   |..   |  ..  |..|||| | | || .||||  ..  ||     | ...    ||  |  .. ||..| |.|.
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq





subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 958-1151 6.6e-25 82.4 In-house 2-197 (198) alignment
Range on Protein: 958-1151
Range on HMM: 2-197/198.0
ERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeEEDRRQITQ
 ....|..| |.  |. |||.|.||     |||. . .  ..|  . |||     | ..| . |         ||   .| ...| .        |.|..
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta...ppstreish

YHYLTWKDFMAPEHP--HGIIKFIRQINSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQLEEED--SVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
| . .||.  .|.     |..   |..   |  ..  |..|||| | | || .||||  ..  ||     | ...    ||  |  .. ||..| |.|.
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 963-1149 9.3e-25 81.7 In-house 92-280 (302) alignment
Range on Protein: 963-1149
Range on HMM: 92-280/302.0
IC--AQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQ-ERKTGDYIER---TLNVSKNKANVGEEEDRRQIT
.      |  ||.. .| .| . .  |.| |... | .. |||.|. .|| .. .||   ||  . . .  .. ..   .|   . | .  ... .. . 
vskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvd

QYHYLTWKDFMAPEHPHGIIKFIRQINSvYslqRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFL
  .. .| |  ||....  .. ..  .| |   .  .||||||||||||||||.   ||   ...   . . |. .|. |   ||. .| |.|
ilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

0044763 (Phosphotyrosine protein) phosphatases II 1224-1446 2.3e-24 81.4 In-house 1-166 (178) alignment
Range on Protein: 1224-1446
Range on HMM: 1-166/178.0
PYDRNRVILTPLPMRENSTYINASFIEGYdnsetFIIAQDPLEntigDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADDEVqydhilvkyvhsescp
|.||.||.|..|.. | | |||||.| ..     ..... | .    |..... |. .|..|...|   ..  ||..|| ...                 
pldrtrvllsnleglersdyinaseilpg.....lylgslppa....ddlellkelgithivnlteelelgflkcdpywpeeag................

yytrrefyvtnckiddtlkvtqFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYK-NNknsgcrSPLTVHCSLGTDRSSIFVAMCILVQHlrlekCVDICA
                      .||  .|..|. ||.. . . |.|.   .... ..      .|  |||| | .||  .||. .. ..      ... .
......................iqylhipipDhgvpdllehflefvefieealdekg......gpvlVHCsaGvgRsgtlvaaylmkkl.....glslee

TTRKLRSQRTgLINSYAQYEFLHRA
  . .|..|   . .  |...|.. 
aielvrerRp.ivpnpgqlrqLyef

0049260 (Phosphotyrosine protein) phosphatases II 1248-1444 4.6e-24 80.2 In-house 1-143 (152) alignment
Range on Protein: 1248-1444
Range on HMM: 1-143/152.0
FIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWaddevqydhilvkyvhsescpyytrrefyvtnckiddtlkvtqfQ
||.|| ..  ||..| |..||. |||||. |. .||.||. |  .    ||..|.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNsgcrsPLTVHCSLGTDRSSIFVAMCILVqhlrleKCVDICATTRKLRSQRTGLINSYAQYEFLH
|  .|. |. ||.    ...|..    .......     |  |||| | .|.  .||. ..       . |..  . . .|..| | . .  |..||.
ylhlpwpDhgvpdlsqlllflllfieklaldkgg.....pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

0048179 (Phosphotyrosine protein) phosphatases II 1005-1151 8.8e-24 79.3 In-house 2-139 (144) alignment
Range on Protein: 1005-1151
Range on HMM: 2-139/144.0
YWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRT
..| ....   .|.. .    |.     |   .|.. .      |.  |...||..| | |. .|.... ...|.. |..... . ||.|||||||||||
snpseilpglylgslptaldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRt

GTLVALDSLIqqleeEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
|||||.. ..     .  .|.....  .| .| . |..  |..||..
gtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1211-1450 3.5e-23 76.7 In-house 53-288 (305) alignment
Range on Protein: 1211-1450
Range on HMM: 53-288/305.0
EENNMKNRSQEIIPYDRNRVILTPLPmreNSTYINASFIEGYD-NSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPRYWADDEVQ-
. .  ||| |..   |.. | |   .    | || | ..         || || ||..|| .|| |. .. |  .||.   .  |  || .||     . 
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

--Y-DHILVKYVhSESCPYYTRREFYVTNCKI----DDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnknSGCRSPLTVHCSLGTDRSSI
      |.|. | | | |     |  .|  ..    |... | ..|.. ||  |  || .    .||.             | . |. |||| |  |.  
lelksgivvenv.sgskpmerdaeiqitllnltysgdqkmsvrhlqwtewp..drgvppckltslellsai.........rgskvpivvhcsagigrtgt

FVAMCILVQHLR-LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 ||.  .....    .|  .    . || ||.  |..  || |.|| ..||
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1051-1192 6.6e-23 75.7 In-house 87-230 (440) alignment
Range on Protein: 1051-1192
Range on HMM: 87-230/440.0
DRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV-YSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFL
. | . ||||  | |   |.    ..|.|...|        ||.|||||||.|||| ..|.||.... .  | . |.. .  .| .|  .||. .|| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YRALLDTGTFGNTDICIDTMASAIESLKR-KPNEGKCKLEVEFE
. |.|.    |.| |  | ..  .| ..  .|.  |. |. |||
heavlegllcgdtliledditerveqiqwpnphtdksplqqefe

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 971-1154 1.5e-22 74.9 In-house 38-218 (255) alignment
Range on Protein: 971-1154
Range on HMM: 38-218/255.0
S-TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQerKTGDYIERTLNVSknkANVGEEEDRRQITQYHYLTWKDFMAP
| |.| |...|  .  | .|||....| .. || .|.| .  . ... |. |  ..   . | . |||..    ...||    .... |.|  | . .||
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleit...stlgekkkthtvkhysykGWieknaP

EHPHGIIKFIRQINSVyslqrGPILVHCSAGVGRTGTLVALDSLIQ----QLEEEDSVSI--YNTVCDLRHQRNFLVQSLKQYIFLYRALL
| .. | . .. .         ...||||.|.||. ..|  ... |    .|.. . | .   . . .||..|.  ..   |  |    .|
elareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

0051082 (Phosphotyrosine protein) phosphatases II 1241-1447 7.9e-22 72.9 In-house 3-149 (151) alignment
Range on Protein: 1241-1447
Range on HMM: 3-149/151.0
STYINASFIEGYdnsetFIIAQDPLEntigDFWRMISEQSVTTLVMISEIGDGPrKCPRYWADDEvqydhilvkyvhsescpyytrrefyvtnckiddtL
|.|||.|...|.     ... . ||.    ||.... |. ..| |.. .    . .||.|. . .                                  .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................i

KVTQFQYNGWPTVDgeVPEVCRGIIELVDQAYNhyknnknsgC-RSPLTVHCSLGTDRSSIFVAMCILVQHlrlekcVDICATTRKLRSQRTGLINSYAQ
.|..... .||. .  .|.    ..|..... .         .   |. |||| | .|. ..||. .. ..      |.. .. . .|..|.|....  |
evlhipildwpdpg..lplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YEFLHRAI
. |...|.
flfqlfal

subfamily_CG42327_pd Subfamily CG42327 1193-1376 1.5e-21 71.4 In-house 16-195 (319) alignment
Range on Protein: 1193-1376
Range on HMM: 16-195/319.0
KLLATADEISKSCsvgeneenNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSET-FIIAQDPLENTIGDFWRMISEQSVTTLVMISEIG
.|.| |||.  ..        . |.|  ...|    ||.|   .  ... |..||.. |||.... .| || .||..  ||||.. ||   ..| .... 
qliaradevPvts........kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

D-GPRKCPRYWA-----DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYnGWPtvDGEVPEVCRGIIELVDQAYNHYK
. | ..|..|.      |..  | .|||   . |.   |    . . . . . . ..| . |  |.  . |||   . .| .. .. .  |
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwl..eaevPaeeaaliamllevrsslk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 897-1161 6.1e-20 66.0 In-house 28-282 (303) alignment
Range on Protein: 897-1161
Range on HMM: 28-282/303.0
YEMLPNRFSDRTTKNSdLKENACKNRYPDIKAYDQTRVKLAvinglqTTDYINANFViGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEE
.| . . .  . .||  . .|  |||. |.   |...|||.       . || |...   . .|| | .| |.  |  |||.|| ||..  ...|    |
fekvvsylppsvsknq.fvknmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdse

YNKAKCAKYWPEKvFDTKQFGDILVKFAQERKTGdyIERTLNVskNKANVGEEEDRRQITQYHYLTWKDFMAPEH-PHGIIKFIRQINSV---YSLQrGP
|.|      .|..  |  .| .  ..  . ..    .    ..  .   | . . .  .  .|| .|     | .    ..| | |..||   ||    |
ydklggdsvfprn.qdflkfeersirvgefkrve..lgdgwvl..kvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds.tp

ILVHCSAGVGRTGTLVALDSLIQQLE-EEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRaLLDTGTFGN
 .    .|.||.||.  ...    |  |. |. . . .  .|  |   || | |. ..|  ||    ..|
tvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt.llaehvldn

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1197-1450 1.8e-19 64.5 In-house 21-268 (281) alignment
Range on Protein: 1197-1450
Range on HMM: 21-268/281.0
TADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTP-LPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR
  |  |  |.| ..  || |||  .|   |  || |   .| .. . || | .|        .|..| | ..|  |||||| ..  |..||. .. .  |
pgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr

-KCPRYWADD---EVQYDHILVKYVHSESCPYYTRREFYVtnCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnknSGCRSPLTVHC
 ||  |.  .    .|.|.. |.|  |          . .      .|  .|.. .. ||  | .|||    ..... .              .|  .||
ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewp..dwqvpessevmlkilrki.........rarstppvihc

SLGTDRSSIFVAMCILVQHLRLEK-CVDICATTRKLRS-QRTGLINSYAQYEFLHRAIINY
| |  ||  ..|. | .| ..      ||     .||   |.  ...  || .. . ....
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_hpo-7_pd Subfamily hpo-7 970-1150 6.9e-19 62.8 In-house 44-220 (263) alignment
Range on Protein: 970-1150
Range on HMM: 44-220/263.0
ESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKtgDYIERTLNVSKnkaNVGEEEDRRQITQYHYLTWKDFMAP
  ||| |...|  .  | .|||.. .| .. || .|.| .  . ... .. |  ..  .  | . .||.. .   ..||    .....| |  | . ..|
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlells...tlgeKkkthtvkhysykgWiekndp

EHPHGIIKFIRQINSVyslqrGPILVHCSAGVGRTGTLVALDSLIQ----QLEEEDSVSI--YNTVCDLRHQRNFLVQSLKQYIFLY
| .. |.. ..           .. ||||.|.||.   .  ... |    .|.. . | .   . . .||..|.  ..   |  |  
elareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

subfamily_egg_pd Subfamily egg 1196-1450 7.5e-19 62.5 In-house 25-270 (307) alignment
Range on Protein: 1196-1450
Range on HMM: 25-270/307.0
ATADEISKSCSVgeNEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDgPR
 ..||||   ..  ...|  | ||. .   |  || |     .    .| |  ..|    ..||.|| || ||  |||||. .. |  .||..   . . 
esvdeislttaa..sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrke.se

KCPRYWADDEVQYDHILVKYVHSEScpyytrrefYVTNCKIDDTLKVTQFQYNGWPtVDGEVPEVCRGIIELVDQAYNHYKNN-KNSGCRSPLTVHCSLG
.|. ||   | .   ..   .. |.         .  . | |  ..||...  |    .    |  .| .. . . |  ..   |      |  |.. ||
rceyywpkaesdslvtvpGslrien.........lkvdskadplfrvtklklvGgd.deerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilG

TDRSSIFVAMCILVQHL-RLE-KCVDICATTRKLRSQRTGLINSYAQYEFLHRAII-NY
  ... .||. | . .| |       .  .   || .|   ..|  .| |..| ..  .
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1213-1448 5.5e-18 60.1 In-house 19-256 (290) alignment
Range on Protein: 1213-1448
Range on HMM: 19-256/290.0
NNMKNRSQEIIpYDRNRVILTPLPMRENSTYINASFIEgYDNSETFIIAQDPLEN-------TIGDFWRMISEQSVTTLVMISEIGDGPRK-----CPRY
..|..| .  .    .||.|     | |. || |...  . |   .|. | |.|.       || .|| |. .  |. .||. |  .  ..     | .|
hemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

W---ADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKiDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAynhyKNNKnsgcrSPLTVHCSLGTDR
    ...|.... . ||  . |      .||  |.  . .  ..||  ...|| ..  .|.|  . ...|...     |..|     .|  |||  |  |
vpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnkl..nvqedtktllsliqkv....kask.....tpvivHcvdGiSr

SSIFVAMCILVQHLR-LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
| .. |. .  | .  ... | . .   .||.||  .| |. .. |   .|.
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1209-1459 7e-18 59.2 In-house 48-299 (310) alignment
Range on Protein: 1209-1459
Range on HMM: 48-299/310.0
ENEENNMKNRSQEIIPYDRNRVILTPLPMReNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIG-DGPRKCPRYWADDEVQ
  ...  |||  ...  |  || |.    |    || | ..      .||| .| ||. || |||||| ..   .....  .| .|  ||  ||    | 
aykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

--YDHILVKYVhSESCPYYTRREFYV----TNCKIDD------TLKVTQFQYNGWPtvDGEVP-EVCRGIIELVDQAYNHyknnknsgcrSPLTVHCSLG
  |  | |  . |||   .   .. |     |  .|.       |.|.  ..  ||  |  || | |  . . .     |           |  |||| |
etygcirvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwp..drgvpdekchtvpqrllaqvrh..........gpcvvhcsag

TDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY-SDLHHIAES
 ||  . ||. . ...|.  . ||.     .|. .|.  |..  || ...|  | .    ...||.
kdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetevaek

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1212-1450 9.2e-18 59.3 In-house 42-270 (288) alignment
Range on Protein: 1212-1450
Range on HMM: 42-270/288.0
ENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEI-GDGPRKCPRYWADDEVQYDH
.|  ..| ...   |  || |.     .   ||.|  .    . . .| || ||. ||. .|.|. |. |  .||..|.   | .|   |.     .  .
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

ILVKYVHSESCPYYTRREFYVTNCKIDDTLK----VTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnknSGCRSPLTVHCSLGTDRSSIFVAMCI
|               .   |.  .|  . .    | .  .. |.  |  |||     . |..             .. |. ||.| |. |.  .. . |
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWd..ddgvPenylsplrllevl.........kslqkPivvhssaGvGrtgtlilili

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 .. |||.  . |     ||| .|   |..  || ..|| . ..
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1184-1452 1e-17 58.5 In-house 25-286 (302) alignment
Range on Protein: 1184-1452
Range on HMM: 25-286/302.0
KCKLEVEFEKLLATADEISKsCSVGENeeNNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTI---GDFWRMISEQS
. ... ||.|. ..  .. | |..  .  |  ||.|...  .| |.|.|.     |.  |.||| .|  . ... |.|| |  ..     .||||. ...
taevkkefkkidtmkvdlek.Ckafkk..nlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

VTTLVMISEIGDGPRKCPRYWA---DDEVQYDHILVKYVHSESCPYYTrREFYV--TNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhy
....|..    .  .    ..    .| ..|... |     |.    .  ....      . ... ..    . |.  . .||.    .|. . .     
ivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWk..qkkvpvkyaeliktaakv....

kNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
  .|.. . ... .    |. | ..|... . |..|  .| . |  . ...||||.  ..|. || .|..|.. |  
.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

subfamily_CG42327_pd Subfamily CG42327 1088-1153 2.3e-17 57.6 In-house 245-311 (319) alignment
Range on Protein: 1088-1153
Range on HMM: 245-311/319.0
LQRGPILVHCSAGVGRTGTLVALDSLIQQLEEE-DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
 ..||. |||| ||||||...| |  |..|||   || | ..|  .|..|   |.. .|| |.|. |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1244-1439 7.9e-17 55.9 In-house 78-269 (301) alignment
Range on Protein: 1244-1439
Range on HMM: 78-269/301.0
INASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPRYWA---DDEVQYDHILVKYVHSESC--PYYTRREFYVTNCKI-
| | .|.   ... ||..| ||.||  ||| |.    | ..||... . .  .||  | .    .... .   .| ...|.      ..|.. |..    
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

DDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnKNSgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINS
 .|  || .||. |.  | .||.    . .|.. .       |.|  . |. |||| |  ||  |..  .| ...  .. ...  . ..|| .|   .. 
fatrtvthyqysewt..drgvPkshaelfdlmelv.......kks..ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt

YAQ
  |
nsq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1204-1452 8.7e-17 56.0 In-house 26-271 (285) alignment
Range on Protein: 1204-1452
Range on HMM: 26-271/285.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIE--GYDNSeTFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRY
 |.    | |   ||  ..   .  ||.|       .  || ||..   | |.| |.| .| || .|. |||.|| .. .. ..|.  . . |  ||  |
nctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WADD---EVQYD--HILVKYVHSESCPYYTRREFYVTNCK--IDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELvdqaYNHYKnnKNSGCRSPLTVHCSL
. .     |..    | .  .. |.        . |.| .    . | . . |   ||  |   || .| .|||    |.  |  |      |. |||| 
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwp..dqlapedarpmiel....ykwvk..kvnpkekpicvhcsa

GTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
|  |.. || .     ..  .  ...    |..|. |   ..|. |. ||.  ...|  
gvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi

subfamily_eak_pd Subfamily eak 1203-1450 1.5e-15 51.5 In-house 42-304 (332) alignment
Range on Protein: 1203-1450
Range on HMM: 42-304/332.0
KSCSVGENEENNMKNrSQEIIPYDRNRVILTPlPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMIS-EIGDGPRKCPRYW
.| |...  |.  .|   .|.||||. | ||.  ....  ||||| .|  .  . .|..  . |. .  ||.|. ||   ..|..  ..  .  |  .|.
lsisetarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

ADDE---VQYDHILVK---YVHSEscpYYTRREFYVTncKIDDTLKVTQFQYNGWPTVDGEVPE-------VC--RGIIELVDQAYNHYKNNKNSGCRSP
 |.    ... .. |.   .|. .    .  | . ..  | ..| .|  ... ||  ..  . |       |    |.. |.  . . ..   .    .|
pdktreelkfGildverkefvkrn...iletrllels..kGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtp

LT----VHCSLGTDRSSIFVAMCILVQHL--RLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 .    . .. |. |. .|| . .|.. .  . .    .     | .|.|   .    |. |.. ....|
psfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy

subfamily_eak_pd Subfamily eak 907-1155 1.7e-15 51.3 In-house 42-303 (332) alignment
Range on Protein: 907-1155
Range on HMM: 42-303/332.0
RTTKNSDLKENACKNrYPDIKAYDQTRVKLAViNGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYW
.. ....  |.  .|   .|  ||.  |.|.    |    ||||  .   .  .|.| .  . |. .  ||.|. ||.   ||.| .  | .  |  ||.
lsisetarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSK-NKANVGEEEDRRQITQYHYLTWKDFMAPEH---PHGIIKFIRQINSVYSL--QR--------GP
|.|  .  .|| . |.  .  | . .  | | .|| |..           |..    ..||.|  .     |....|   ....|   ..         |
pdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap

IlVHCSAGVGRTGTLVALDSLIQQLEE--EDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
| . .. |  |.|..| .| ||. ...  ... |. . .   ...|.  |   .|. |.| ..||
i.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivld

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1207-1314 2.6e-15 51.0 In-house 41-161 (350) alignment
Range on Protein: 1207-1314
Range on HMM: 41-161/350.0
VGENEENNMKNRSQEIIPYDRNRVILT--PLP------MRENSTYINASFIEGY-----DNSET-FIIAQDPLENTIGDFWRMISEQSVTTLVMIS-EIG
. |  |   ||| ..|.||...||.|   . .        . . ||||....        |..  .| .| || .|. ||...| .  |. ..... .. 
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

DGPRKCPRYWADDEvqYDHILVK
 . .|| ||| . .  || | ||
lnlekcyrYWqegs..ydditvk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1191-1289 3.3e-15 50.4 In-house 17-118 (347) alignment
Range on Protein: 1191-1289
Range on HMM: 17-118/347.0
FEKLLATAdeISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPM-----RENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV
|.. ||.       ... | | .  ||||..    |  ||.|.|         .  |||||| |   . |. .|..| || .|. |||.|.|   || .|
fdenlany..spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

MISE
 | |
tife

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1217-1450 5.2e-15 49.9 In-house 47-275 (312) alignment
Range on Protein: 1217-1450
Range on HMM: 47-275/312.0
NRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMIS-EIGDGPRKCPRYWADdEVQYDHILVKY
||  .|  .|| |  |.     ..  || | |.    . | |...| |||||.  ||..    . |......  . ||  || .| .|  | . ..  . 
nrypniqcwdrgrftla....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd.ivgfvdledhr

VHSESCP----------YYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNsgcrsPLTVHCSLGTDRSSIFVAMC
|..|.|             | | . |      .  |. ..|.  ||  |  .|. |     |.       |..|.     |.  ||| |  |.  .. . 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswp..dhgmpdscdtalrllsav....kkdkk.....pviahcsagvgrtgtlalie

ILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 ..  ||  .  ..  .   || .|.  .. ..|| .  |.....
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1256-1444 7.6e-15 49.6 In-house 5-197 (199) alignment
Range on Protein: 1256-1444
Range on HMM: 5-197/199.0
ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADDEV---QYDHILVKYVHSESCPYYTRREFYVTNCKI--DDTLKVTQFQYNG
  .| .| || .|. |||.|. |     .||. .         | ||.  |    .|  . |      . | ||   . .||       | .....|.  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPTVDgeVPEVC--RGIIELVDQAYNHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK--CVDICATTRKLRSQRTGLINSYAQYEFLH
|       |.|.   |..    .  ..|...|.    .|. |||| |   . .|||. | |.     |   ||.   ...||  | |.| |  .|.|..
wkekt..tpnvalfvgfvvasrevskkyeqekd....apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1257-1444 8.2e-15 49.5 In-house 5-196 (198) alignment
Range on Protein: 1257-1444
Range on HMM: 5-196/198.0
TFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADDEV---QYDHILVKYVHSESCPYYTRREFYVTNCKI--DDTLKVTQFQYNGW
 .| .| || .|. |||.|. |     .||. .         | ||.  |    .|  . |      . | ||   . .||       | .....|.  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PTVDgeVPEVC--RGIIELVDQAYNHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK--CVDICATTRKLRSQRTGLINSYAQYEFLH
       |.|.   |..    .  ..|...|.    .|. |||| |   . .|||. | |.     |   ||.   ...||  | |.| |  .|.|..
kekt..tpnvalfvgfvvasrevskkyeqekd....apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1210-1305 1.4e-14 48.3 In-house 93-182 (244) alignment
Range on Protein: 1210-1305
Range on HMM: 93-182/244.0
NEENNMKNRSQEIIPYDRNRVILTPLPMreNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGprkcPRYWADDE
| .|. |||    .|.| ||| |.   |    |||||||.     .  .|..| || .|  |||.|. |. |  ||..  . .       || | |
npnnswknregaglpfdfnrvplskgsm..gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee....deywpdse

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 956-1155 1.8e-13 43.8 In-house 111-307 (346) alignment
Range on Protein: 956-1155
Range on HMM: 111-307/346.0
YKERKKFICAQGP---MESTIDDFWRMIWEQHLEIIVMLTNLEEYnKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGeEEDR
..  .|.| || |    || ..||| ||........ ..   .   |   .  . ..    .  | ....  .   .||  | |..|  .    | . | 
fqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddkl.kntttslfndenggyqytgkmfinnrradvsgdpkeytievlpe....g.nsds

RQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRA
     .|.  || .  | .   |||.| |. |   .|   . |    | ||. ...     |.||..     |.. . ... ||   |.|. ||  .|  
vicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

LLD
..|
vfd

0048076 (Phosphotyrosine protein) phosphatases II 1334-1448 2.3e-13 45.6 In-house 37-140 (145) alignment
Range on Protein: 1334-1448
Range on HMM: 37-140/145.0
CKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNnknsGcrSPLTVHCSLGTDRSSIFVAMCILVQhlrleKCVDICATTRKLRSQRTGL
.   . |. . .||  .|. | .||.  . ..|....  ...|.    |   |  |||| | .|.  .||.... .     . |..  . ...|||| | 
tselellerlgiqylylpwpDhgvpdllellleflefieealke....g..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpga

INSYAQYEFLHRAII
. .  |..||.... 
vpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 1333-1445 6.9e-13 44.0 In-house 48-139 (144) alignment
Range on Protein: 1333-1445
Range on HMM: 48-139/144.0
NckiddtlkvtQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNknsgcrSPLTVHCSLGTDRSSIFVAMCILVqhlrlEKCVDICATTRKLRSQRTG
.           .||  .|. | .||.    ..|...   ......       |  |||| | .|.  .||.....     .. ...  . . .||.| |
e..........giqylhlpwpDhgvpdllellleflefieealeeg......gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpg

LINSYAQYEFLHR
 . .  |..||..
avpnpgqlrfLle

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1091-1154 8.7e-13 42.8 In-house 229-292 (297) alignment
Range on Protein: 1091-1154
Range on HMM: 229-292/297.0
GPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
 ..||||||||||.| .|  | ....|  .    .   .  ||.||  |||.|.|. .|| | |
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

fn3 Fibronectin type III domain 340-425 1.2e-12 40.9 Pfam-A 6-85 (85) alignment
Range on Protein: 340-425
Range on HMM: 6-85/85.0
VETTGSTASTITIGWNPPPpDLIDYIQYYELIVSESGEVPkvieEAIYQQNSRNL-PYMFDKLKTATDYEFRVRACSDLTktCGPWS
.  .. |....|. |.||. |  . |..||. ..|.|.      |   ....|.   ... .||  |.|||||.|... .  .||.|
lsvsevtstsltlsWsppk.dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngag..egpeS

fn3 Fibronectin type III domain 244-320 4e-12 39.3 Pfam-A 8-84 (85) alignment
Range on Protein: 244-320
Range on HMM: 8-84/85.0
AKAVGANKIYLNWTVN-DGNDPIQKFFITLQEAGTPTftYHKDFINGSHT-SYILDHFKPNTTYFLRIVGKNSIGNGQP
...|..... |.|.   ||..||... ....|.|..   ..| | . ..| |..| . ||.|.| .|.   |  |.|..
vsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 915-1008 1.1e-11 38.8 In-house 94-180 (244) alignment
Range on Protein: 915-1008
Range on HMM: 94-180/244.0
KENACKNRYPDIKAYDQTRVKLAviNGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNkakcaKYWPE
 .|. |||      .|  || |.  .|     |||| ||       ..| .| |.  |  |||.|. |.|....|.|  .|| .     .|||.
pnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpd

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1265-1435 2.5e-11 38.1 In-house 39-205 (255) alignment
Range on Protein: 1265-1435
Range on HMM: 39-205/255.0
LenTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGevPEV
|  |.  |...|  .  ...||...  . |  || .|.    |.  .. .. |   .| . .    .|   |  .   | .|. ..|.||.   .  || 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna..Pel

CRGIIELvdqaynhYKNNKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQ----HLRLEKCVDI--CATTRKLRSQRTGLIN
 | | ..       .|  ..|    .. |||| |  ||. || . .. |     |.  . |..      ..|||.|.. |.
areilni.......lkvvrds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih

PTEN_1 1034-1109 3.3e-11 38.4 In-house 69-149 (196) alignment
Range on Protein: 1034-1109
Range on HMM: 69-149/196.0
ERTLNVSKNKAN----VGEEEDRRQITQYHYLTWKDFMAPEhPHGIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTLVA
   .|.|  ...      .|| ...  .|. . ..|. ||   . ........ . ...  ... .|||| ||.||.||.||
tlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1094-1156 5.8e-11 36.6 In-house 2-64 (69) alignment
Range on Protein: 1094-1156
Range on HMM: 2-64/69.0
LVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
.||||.| |||||..|.   . ..  |  | |.| |  .|  |  .|    .|||.. || ..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1338-1449 7.2e-11 36.1 In-house 87-192 (440) alignment
Range on Protein: 1338-1449
Range on HMM: 87-192/440.0
DTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAyNHyknNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSY
..  . |..|.|||  |  ||...  .......  |.   ...    .|| |||| |. |... .|.  .... .    .|| .    .|..|  .... 
esrtlkqyhyqgwp..dkgvpkfagpvlkmiqdv.ne...sqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

AQYEFLHRAIIN
 || |.| |...
eqyafvheavle

subfamily_CG42327_pd Subfamily CG42327 1384-1452 7.5e-11 36.3 In-house 247-316 (319) alignment
Range on Protein: 1384-1452
Range on HMM: 247-316/319.0
RSPLTVHCSLGTDRSSIFVAMCILVQHLRLE-KCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
. ||.|||| |. |. . .|  | ...|    . |||  .   .| .|.  . .  ||||... . .|. 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 915-1001 7.6e-11 36.1 In-house 32-117 (332) alignment
Range on Protein: 915-1001
Range on HMM: 32-117/332.0
KENACKNRYPDIKAYDQTRVKLAVINGlqTTDYINANFVIGYKERKKFICAQGPMESTI-DDFWRMIWEQHLEIIVMLTNLEEYNKAK
 .|   || | . ..|..||.||  .|    |. ||..| || ..  .| || |..      ||||. |..  .|... ...| .| |
lnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1223-1358 1.8e-10 35.3 In-house 3-128 (130) alignment
Range on Protein: 1223-1358
Range on HMM: 3-128/130.0
IPYDRNRVIltplpmreNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGprkcPRYWADDEVQY---DHILVKYVHSE
.... .|.         . |||||||.   ...  .. .| || .|  |||.|. |. |  ||..  . .       || | |      ..|.|   . .
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee....deywpdsePlewyeediivtltdrd

SCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTvDGEVP
   .    .. . .  ..    .| ||   ||. ||  |
efknikasnleiesdlneshqaltmfqisnwps.dgttp

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1203-1262 1.9e-10 34.8 In-house 38-94 (95) alignment
Range on Protein: 1203-1262
Range on HMM: 38-94/95.0
KSCSVGENEENNMKNRSQEIIPYDRNRVILTplpMRENSTYINASFIEGYDNSETFIIAQ
 . .||  | |  |||  .|.|||  ||.||    . .| |||| |..||   . .| ||
apytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 955-1021 2.2e-10 34.5 In-house 231-293 (440) alignment
Range on Protein: 955-1021
Range on HMM: 231-293/440.0
GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLeeyNKAKCAKYWPEKVFdTKQFGDILV
||  .. ||..| |..||. ||||.. . ..  |.|| .|   |   |. ||| .   .  || . |
gyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntr.svtfgpftv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1095-1156 2.5e-10 34.5 In-house 2-63 (69) alignment
Range on Protein: 1095-1156
Range on HMM: 2-63/69.0
VHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
||||.| |||||..|.   . ..  |  | |.| |  .|  |  .|    .|.|.. || ..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 939-1033 8e-10 33.1 In-house 7-95 (130) alignment
Range on Protein: 939-1033
Range on HMM: 7-95/130.0
INGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNkakcaKYWPEKVFDTKQFGDILVKFAqERKTGDYI
.. ||  .||||.||      .... .| |.  |  |||.|. |......|.|  .|| .     .|||.         ||.|  . .|.  ..|
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtlt.drdefkni

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1208-1287 1.3e-09 32.1 In-house 42-114 (303) alignment
Range on Protein: 1208-1287
Range on HMM: 42-114/303.0
GENEENNMKNRSQEIIPYDRNRVILTplpmreNSTYINASFIEgYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMI
 .  .|  |||  ..|  |  .| |.      .|.|| ||..|  | |   |..| ||  |  |||.|| || |  ....
nqfvknmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 872-967 2.1e-09 31.4 In-house 4-95 (95) alignment
Range on Protein: 872-967
Range on HMM: 4-95/95.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDlKENACKNRYPDIKAYDQTRVKLAVingLQTTDYINANFVIGYKERKKFICAQG
|||   .     . | ..|  |  |.  ..       |  |  . |  |||. .|  || ||| |.     . .||||| || ||  .. .|.|||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgss.eanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 911-1034 2.4e-09 31.2 In-house 31-165 (347) alignment
Range on Protein: 911-1034
Range on HMM: 31-165/347.0
NSDLKENACKNRYPDIKAYDQTRVKLAVINGLQ-----TTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLT------NLEEYNK
 .. . .  |||  | |  |.||| |.  .  .     .  ||||  .   . .|..| .| |. .|. |||.|.   ..  .| .        .||...
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefan

AKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIE
|  .   |     .|. |   |   |  .  . ||
atlslvapaptasskdigsspvpidqiarereqie

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 891-959 4.5e-09 30.1 In-house 22-89 (440) alignment
Range on Protein: 891-959
Range on HMM: 22-89/440.0
YGFLREYEMLPNRFSDRTTkNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKER
  |  |. .||. .|. .   . | .|  |||| .| |||..|| |  ..|.  .||||| .. | . |
rafedewsllpsglsqpsd.iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1213-1298 5.5e-09 29.9 In-house 33-119 (332) alignment
Range on Protein: 1213-1298
Range on HMM: 33-119/332.0
NNM-KNRSQEIIPYDRNRVILTPLPMREnsTYINASFIEGYDNSETFIIAQDPLEN-TIGDFWRMISEQSVTTLVMISEIGDGP-RKCP
|||  ||   .  .|..|| |.|   ..   . |||...|| .  ..|.|| |... |   ||||.||.  . .... .| .   ||.|
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap

0038934 (Phosphotyrosine protein) phosphatases II 1057-1109 6.2e-09 31.3 In-house 81-134 (194) alignment
Range on Protein: 1057-1109
Range on HMM: 81-134/194.0
QYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL-QRGPILVHCSAGVGRTGTLVA
.|. | ..|....     . .|.. .. ...  . | ..||| ||.||||||||
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1207-1315 9.5e-09 29.0 In-house 42-165 (349) alignment
Range on Protein: 1207-1315
Range on HMM: 42-165/349.0
VGENEENNMKNRSQEIIPYDRNRVILTPLPM----RENS----------TYINASFIE--GYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV-MISE
. |  |   ||| ..|.||.  ||.|   .      ..|           |||| ...   ..  . .|  | ||  |. ||...|  . |  .. . ..
lseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLndd

IGDGPRKCPRYWAddEVQYDHILVKY
   . .|| .||   | .|. | || 
kelslekcdiywq..elsysnitvkl

Ig_2 Immunoglobulin domain 35-126 1.1e-08 27.0 Pfam-A 11-78 (80) alignment
Range on Protein: 35-126
Range on HMM: 11-78/80.0
AEIGKNVSLECASENE---AVAWKLGNQTINKNhtrykirteplksnddgsE-NndsqdfikyknvLALLDVNIKDSGNYTCTAQT--GQNHSTEFQV
.. |.|| | |....     | |..........                  . .            | .  |. .|||.|||.|.   |.. |. ..|
vtegenvtLtCqapgnptpkvqwykdgeelsqs..................qna............lfipnvsaedsGtYtCrasnsegskqsnsvev

fn3 Fibronectin type III domain 452-532 2.2e-08 27.3 Pfam-A 11-83 (85) alignment
Range on Protein: 452-532
Range on HMM: 11-83/85.0
VtRGNSIAINWDVPKTPNGKVVSYLIHLlgNPMSTVDremwGPKIRRIDEPHHKTLYESVSPNTNYTVTVSAITRHKkNGE
| . .|. ..|. ||...|....| ...   .... .     .| ........    .   |.|.|...| |....  .|.
v.tstsltlsWsppkdgggpitgYevey..rekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngag.egp

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1250-1302 4e-08 27.0 In-house 230-280 (440) alignment
Range on Protein: 1250-1302
Range on HMM: 230-280/440.0
EGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDgpRKCPRYWA
||| . ..|| .| ||. |. ||||.. .  ..|..|. .. |  . |  || 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..ktcsiywp

subfamily_hpo-7_pd Subfamily hpo-7 1265-1433 7.4e-08 26.6 In-house 43-209 (263) alignment
Range on Protein: 1265-1433
Range on HMM: 43-209/263.0
LENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGevPEV
| .||  |...|  .  ...||...  . |  || .|.    |.  .. .. |   .. | .    .|.  |  .   | .|....|.||. . .  || 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd..pel

CRGIIELVDQAynhyknnKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQ----HLRLEKCVDI--CATTRKLRSQRTGL
 | |..... |       .||    .| |||| |  ||. |. . .. |     |.  . |..      ..|||.|.. 
areilnilkva.......rns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkra

V-set Immunoglobulin V-set domain 35-119 8.1e-08 23.1 Pfam-A 13-102 (114) alignment
Range on Protein: 35-119
Range on HMM: 13-102/114.0
AEIGKNVSLECASE---NE-AVAWKLGNQ------TINKNHTRYKIRTEPLKSNDDGSENNDSqdfiKYKNVLALLDVNIKDSGNYTCTAQTGqN
.. |..|.|.|  .   |. .. |  ...       |....   . .... .|..    .| |    |..  | . ... .||| |||.. .  |
vaeGgsvtLpCfysssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngs....ksdfsLtiqnlrleDsGtYtCavsds.n

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1388-1449 8.3e-08 26.5 In-house 2-63 (69) alignment
Range on Protein: 1388-1449
Range on HMM: 2-63/69.0
TVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
 |||| || |.  |.|. . .  .. || |||    . .|  |  ..    .| |.| |...
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_PTPDC1_pd Subfamily PTPDC1 1052-1143 1.1e-07 26.4 In-house 80-162 (182) alignment
Range on Protein: 1052-1143
Range on HMM: 80-162/182.0
RRQITqYHYLTWKDFMAPEhPHGIIKFIRQINSvySLQRGPILVHCSAGVGRTGTLVALdSLIQQLEeedsVSIYNTVCDLRHQRNFLVQSL
...|. .. ..|||. ..   . |.  .. ...  .||.| . ||| || |||| |.|   |. . .    ..  ...  .|..|   .|. 
eqgiy.vynfgwkDygvas.leriLdivkvvaf..alqegkvavhChaGlGrtGvliac.ylvyakr....ltaekaiklvrskrpksiqtr

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1357-1453 1.1e-07 25.7 In-house 242-340 (347) alignment
Range on Protein: 1357-1453
Range on HMM: 242-340/347.0
VPEVCRGIIELVDQAYNHYKNN--KNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
 |.  . .. ||   ...  .    | . ..|. | | || |||.  |   |... .   |  |  .  .|.| ||.|..     | .  || . |  |
ypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylkl

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1389-1450 1.4e-07 25.8 In-house 2-63 (69) alignment
Range on Protein: 1389-1450
Range on HMM: 2-63/69.0
VHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
|||| || |.  |.|. . .  .. || |||    . .|  |  ..    .| |.| |... 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 912-1010 1.7e-07 24.3 In-house 22-88 (169) alignment
Range on Protein: 912-1010
Range on HMM: 22-88/169.0
SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINAnfvigykerkkficaqgpmestiddfwRMIWEQHLEIIVMLTNLEEYNkakcaKYWPEKV
..|  |  |||     |  .|||||  .     .|||||                           |||||    .||.| . .. |      .|||| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpeke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 912-1010 2.3e-07 23.8 In-house 21-87 (169) alignment
Range on Protein: 912-1010
Range on HMM: 21-87/169.0
SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINAnfvigykerkkficaqgpmestiddfwRMIWEQHLEIIVMLTNLEEYNkakcaKYWPEKV
..|  |  |||     |  .|||||  .     .|||||                           |||||    .||.| . .. |      .|||| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpeke

0048567 (Phosphotyrosine protein) phosphatases II 1056-1110 3.6e-07 24.7 In-house 28-97 (157) alignment
Range on Protein: 1056-1110
Range on HMM: 28-97/157.0
TQYHYL------TWKDFMAPE---HPHGIIKFIRQINSVY---SLQRGPILVHCSAGV---GRTGTLVAL
 ...|.       . || ..    . . ...||...|...   .|....| |||.||    |||.||...
ynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1338-1454 9e-07 22.9 In-house 213-347 (350) alignment
Range on Protein: 1338-1454
Range on HMM: 213-347/350.0
DTLKVTQFQYNGWPTV-DGEVPEVCRGIIE----LVDQAY--NHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQ-HLRL-------------EKC
| . | |.|.. |. .     ||    ..|    |.|. .  .|..|..     ||. |||| |  |  ..|..  |..  . |              | 
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars....spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaakt

VD-ICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLH
 | |  .  .||.||  .. .  |. |.. |. .|  |.
rDlisiivnelrkqrismvqnldqfifiYeallfyfaLr

subfamily_DSP23_pd Subfamily DSP23 1058-1145 9.6e-07 23.6 In-house 54-134 (148) alignment
Range on Protein: 1058-1145
Range on HMM: 54-134/148.0
YHYLTWKDFMAPeHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALDsLIQqleeEDSVSIYNTVCDLRHQRNFLVQSLKQ
.. |  .|.. |  .. . .|.| ..   . .   . |||  | |||||..|   |..    |  ..  ... ..|..|   |....|
lvrlriddyhpp.aleqvvefvrvveeaee.kneavsvhcllgrgrtgtmlacy.lvk....erklaaaeaiaevrrlrpgsvetveq

PTPc_motif_SM00404 1036-1109 1.8e-06 22.9 In-house 31-99 (140) alignment
Range on Protein: 1036-1109
Range on HMM: 31-99/140.0
TLNVSKNKA-NvgEEEDRRQITQYHyltWKDFMAPEHPH---GIIKFIRQInsvySLQRGPILVHCSAGVGRTGTLVA
 .||....  .  .|. ..|| |.     .|    .  .    ...||...      ..| .|||| ||| |..||..
vinvteevslt..kensgfqilqip...lddnekdklskyldkvldfiena....ekkggkvlVHCqaGvSRSatlii

Ig_2 Immunoglobulin domain 135-233 1.9e-06 19.8 Pfam-A 4-80 (80) alignment
Range on Protein: 135-233
Range on HMM: 4-80/80.0
LQSTPDRIkrKIKQDVMLYCLIEmypQNETTNrnLKWLKDGSQFEfldtfssisklndTHLN--FTlefTEVYKKENGTYKCTVfDDTGLEITSKEITLF
|...| ..    ...| | | ..   .|.|..  ..| |||....             .. |  |.    .|  ...||| |..   ... ..|. ....
lsapptvv..tegenvtLtCqap...gnptpk..vqwykdgeels.............qsqnalfi...pnvsaedsGtYtCra.snsegskqsnsvevt

V
|
v

V-set_CD47 CD47 immunoglobulin-like domain 22-119 2.1e-06 15.0 Pfam-A 11-109 (130) alignment
Range on Protein: 22-119
Range on HMM: 11-109/130.0
CAICVQGSVKQEWAEIGKNVSLECASEN----E----AVAWKLGNQTINKNHTRYKIRT-EPLKSNDDgsenndsQDFIKYKNVLAlLDVNIKDSGNYTC
  ....  .. |     . |...|  .|    .     | ||. |. |.....  |. | |   |          ....| .  |  || . . ||||||
aqlvfnkvksveytvCndtvvipCdvdnleyknisevyvkWkfknkdififnktekkstsesfpsakl.......sellkgdasLk.ldfsdalsGnYtC

TAQTGQN
 .   .|
evtelsn

DSPc Dual specificity phosphatase, catalytic domain 1034-1109 2.6e-06 22.3 Pfam-A 20-92 (133) alignment
Range on Protein: 1034-1109
Range on HMM: 20-92/133.0
ERTLNVSKNKANVgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVySLQRGPILVHCSAGVGRTGTLVA
. ..||.|.. |    ..  .  .|  .  .|.   .    . . .. |...   ... .|||| ||. |..||..
tlvinvtkevpnn..naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii

DSPc Dual specificity phosphatase, catalytic domain 1034-1109 2.6e-06 22.3 In-house 20-92 (133) alignment
Range on Protein: 1034-1109
Range on HMM: 20-92/133.0
ERTLNVSKNKANVgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVySLQRGPILVHCSAGVGRTGTLVA
. ..||.|.. |    ..  .  .|  .  .|.   .    . . .. |...   ... .|||| ||. |..||..
tlvinvtkevpnn..naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1001-1143 4.3e-06 20.4 In-house 148-288 (332) alignment
Range on Protein: 1001-1143
Range on HMM: 148-288/332.0
K-CAKYWPEKVfDTKQFGDILVKFAQERKTGdYIeRTLNVSknkanVGEEEDRRQITQYHYLTWKDFM-APEHPHGI-----IKFIRQINSvYSLQRGPI
| | |.||||    |.|  . .. ....    .. .|.|..     | |... .|    |.  | |    ||.   .     ...||  .    .  |||
kicrkfwpekr.skkdfpalsiqasddhset.hm.ktfnlt.....vtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskk.tgvcigpi

LVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSL
.. |..|| .     ..| .. .. ||  | . .|.  .. ||   ....
mlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtv

subfamily_Paladin_pd Subfamily Paladin 1056-1115 6e-06 15.4 In-house 202-264 (314) alignment
Range on Protein: 1056-1115
Range on HMM: 202-264/314.0
TQYHYLTWKDFMAPEHP--HGIIKFIRQINSVYSLQRGPILV-HCSAGVGRTGTLVALDSLIQ
 .|| .   .. ||.      ... .....|..| . ||.||  |  |.||| |  ..  || 
lsyhriplpeqkapleedldqllevlkevpsllskedgpalvFschsGkgrTttamvvavLil

I-set Immunoglobulin I-set domain 136-222 8.4e-06 17.5 Pfam-A 4-81 (90) alignment
Range on Protein: 136-222
Range on HMM: 4-81/90.0
QSTPDRIKRKIKQDVMLYCLIEMYPQNEttnrnLKWLKDGSQFEFldtfSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGL
. ...... .. ..| | | .|  |. .      .|.||||. .     |.  |.. .. . ||....| ....|.|.|..   .| 
tqklkdvevseGesvelectveGepeps.....vsWakdgselks....sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagk

subfamily_CDC14_pd Subfamily CDC14 1079-1110 8.8e-06 19.8 In-house 252-283 (328) alignment
Range on Protein: 1079-1110
Range on HMM: 252-283/328.0
IRQINSVYSLQRGPILVHCSAGVGRTGTLVAL
...  ..    .| | ||| ||.||||||.| 
vkkfleiaekaeGaiavhCkaGLGrtGtLiac