Gene Ptp69D in Drosophila melanogaster

Synonym: 69D, CG10975, CT30751, DPTP, DPTP69D, Dmel\CG10975, Dptp69D, PTP69D, PTPase, Ptp, Ptp69d, R-PTP 69D, dptp69D, dptp69d, ptp69D, ptp69d, Dmel_CG10975, Ptp69D

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Ptp69D
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP039_AA protein Get Run
DmelP039_AA_875-1158 phosphatase_domain Get Run
DmelP039_AA_1170-1452 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Ptp69D_pd Subfamily Ptp69D 871-1176 1.1e-155 512.4 In-house 2-305 (307) alignment 
Range on Protein: 871-1176
Range on HMM: 2-305/307.0
GPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPME
|.|...|||.|.|.|..|||.|...|||.|..|..|..||.|. ||||.||||.||||.|.|||||..||| ...|||||.|..||||.||||.||.|.|
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

STIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPE
.||.||||||.||....||||.||.|.|..|||||||.   |..|.||||||...|.|..|||.|.|.|||.|...||.||.|...||||..|||...||
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

HPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMA
...|..|.|.|....|.|.|.||.|||||||||.|..||||||.|||..||.|.|..||.|||.|||.|||||.||.||||||||. ..|.||...|...
vargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle

SAIESL
.|||.|
daierl
subfamily_Ptp69D_pd Subfamily Ptp69D 1169-1453 1.2e-127 420.3 In-house 9-288 (307) alignment 
Range on Protein: 1169-1453
Range on HMM: 9-288/307.0
MASAIESLKRKPNEGKCKlevEFEKLLATadEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENT
...|..| ||....|..|   |.||| |.  ||.||..|.|..||..|||...|...|..||.|......|.|.|||||||.||.....||.||||.|.|
leealksrkrdtdfglak...eyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

IGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWA-DDEVQYDHILVKYVHSESCPYYTRREFYVTNCK-----IDDTLKVTQFQYNGWPtvDGEVPEVC
||||||||.||.||..||.|.... .| ||..||. .|||||..||||.|..|....|..||..|...|     ..|. ||.|..|.||.  | .||||.
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPeva

RGIIELVDQAYNHYKNNknsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
||...|..|....||.|     |||..||||.|..||.||||...|.|.|..|..|||..|...|||||. |..|..||.||.||...||. 
rgllklieqvrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPRD_pd Subfamily PTPRD 872-1202 2.6e-116 384.5 In-house 4-326 (564) alignment 
Range on Protein: 872-1202
Range on HMM: 4-326/564.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRfSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMES
||.  .|.. ... ... |. | .||. . .. .  |..... ..|  |||| .| |||..||.|  ..| . .|||||.|. ||..||..| .|||...
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEH
||.|||||.|||. ..|||||.||| .| ||.||||||  .|...|.. |.. .| .  ||. ||....|.|     ... |...|.|.  | |  .||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..gtetygeltVtleeeeeladyeirtfklkkkk.....ssesreVrqFhFtsWPdhgvpes

PHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMAS
. .....||..... . ..|||.|||||||||||| ...|.......||. | ||..|  ||.|||..||. .||||...|.|.  ..|||.. .... .
atslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkq

AIESLKRK-PNEGKCKLEVEFEKLLaTADEIS
... |... ....  .||.||..|  ||.|| 
hlqkLaeveedtemtgleleFqrLa.takeie
0051299 (Phosphotyrosine protein) phosphatases II 872-1155 1.3e-97 322.0 In-house 4-284 (288) alignment 
Range on Protein: 872-1155
Range on HMM: 4-284/288.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMES
.|.  .|..........  .|.|.|.|.|.. . |.|.. . |.||  ||||.|| .||..|||| |..|  ..|||||... ||.  .|||..|||...
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnVGEEEDRRQITQYHYLTWKDFMAPEH
|..|||||.|||. ..|||||.|.|... |||.|||.   .....||| |..  | . .||. ||| |....  .. ..  |..|..||..| |. .|..
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldl.ldgdgesrtvthfhytnwpdhgvpds

PHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|  ...|.|....... . ||..||||||||||||..||| |..|||.|  |.....|. ||.||...||.. ||.|.|.|||.
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0040438 (Phosphotyrosine protein) phosphatases II 877-1191 7.2e-97 319.7 In-house 4-310 (317) alignment 
Range on Protein: 877-1191
Range on HMM: 4-310/317.0
DLENAYKNRHKDTDYGFLREYEMLPNRFSDrTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDF
||..|.. ..|   ...|.|.|.|.. . | |.. . |.||  |||||||  ||..|||| ...|   .|||||..| |.....|||..|||...|..||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGII
|||.|||....|||||.|||... |||.|||.   .|...||. |.. .| . .... ||| |...     .... |..|..||..| |. .|..|  ..
wrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.....gdsesrtvthfhytgWpdhgvppspdlll

KFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL
.|......... . ||.|||||||||||||..|.. ...|||.|  |.....|. ||.||.  ||.. ||.|||.|||.  ....|....   ....  |
dfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl

KRKPNEGKCKLEVEF
....  .. ||... 
liplalddvklkeke
subfamily_PTPRB_pd Subfamily PTPRB 872-1156 1.5e-96 317.9 In-house 6-284 (293) alignment 
Range on Protein: 872-1156
Range on HMM: 6-284/293.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMES
||.  ..|. .|. ..|.|..|  |||.| .  .|...| ..|..|..|||| .| .||..||||| ... ...||||||.. ||. ...|| .|||. .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTkQFGDILVKFAQERKTGDYIERTLNVSKnkanvgeEEDRRQITQYHYLTWKDFMAPEH
|.||||||.||.. .||||||.| |  | || .|||..  .. ..||| |.. .|... |.. |.|...|       |...|...|||...| |.  ||.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek.......ekeerkvrqyhftsWpdhgvPek

PHGIIKFIRQINSVY--SLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
.. ...|.|.....   . ...||.||||||||||||..||| |.|..|||| | |. .|..||..||.|||. |||||.....|| 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
0050432 (Phosphotyrosine protein) phosphatases II 870-1156 2.1e-96 318.2 In-house 23-298 (308) alignment 
Range on Protein: 870-1156
Range on HMM: 23-298/308.0
AGPIHRLDLENAYKNrhKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLavinGlQTTDYINANFVIGY--KERKKFICAQG
  ... ||| .....  ..  ... .|.| |.. . ..... . |.||  ||||.|| .||..||||    . ...|||||..| ||  | ..|||..||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqg

PMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVF-DTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeeDRRQITQYHYLTWKDF
|...|..|||||.|||. ..|||||.|.|... |||.|||...  .....|.. |..  | . .||. ||| ..... .     . |..|..||..|.|.
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.....esrtvthfhytnWpdh

MAPEHPHGIIKFIRQINSVYslQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
 .|..|  ...|........  . |||.||||||||||||..||| |..|||.|  |.....|. ||.||.. ||.. ||.|||||||. 
gvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 877-1194 4.2e-96 316.7 In-house 6-318 (318) alignment 
Range on Protein: 877-1194
Range on HMM: 6-318/318.0
DLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDF
|||.  .. ... .  . .|||.|    .  |. .|  . |. |||| .| |||.|||||  ..| ...||||||.. ||...|..| ||.|.  ||.||
dleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDf

WRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGII
|||.|||.  .|||||..||  |||...|||.|  .....|.. |.  .| ...||. |...|...     |||. ||. |||| .| |   ||.. ...
WrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrt.....eeeesrqvrqyhytsWpdegvpesgasll

KFIRQINSVY-SLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIES
...||....  . ..|||.|||||||||||. .|.|.|......|  | ...||  ||.||| .||  .||.|.| .||.  . |.|..  . ..| |. 
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LKR-KPNEGKCKLEVEFEKL
|.. .|. |. ....||..|
lreqdpesgttemdaefqrl
0036941 (Phosphotyrosine protein) phosphatases II 882-1168 2.6e-94 311.1 In-house 4-288 (297) alignment 
Range on Protein: 882-1168
Range on HMM: 4-288/297.0
YKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLaviNGlQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
.. ....  ...|.|.| |.... . ... . |.|| .||||.|| .||.|||||   .. . .|||||..| ||.  .|||..|||...|..|||||.|
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERK--TGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFI
||. ..|||||.|.|... |||.|||... .....||. |..  . .   .||. ||| |...     .... |..|..||..| |. .||.|  ...||
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.....gngesrtvthfhytgwpdhgvpespaslldfi

RQINSVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLE---EEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDT
.....|..|  . ||.||||||||||.||..|.| ..||||   .|  |.|...|. ||.||.. ||.| ||.|||.|||.   ...|..... 
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 873-1191 1.6e-93 308.2 In-house 5-318 (319) alignment 
Range on Protein: 873-1191
Range on HMM: 5-318/319.0
IHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDrTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMEST
|.  .|.. .|. .. .. .. .|...| .  .| |..... .||  ||||..|.|||.|||.|. ..| . .|||||.|. ||.||.||| .|.|.| |
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

IDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFdtKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEeedrRQITQYHYLTWKDFMAPEHP
|.|||||.||..  |.||||.| |  | |. |||||. |  ...| ..|.  .|... ||| | |.. |....|      |......|. | |   ||. 
iedfWrmvWeeessivvmltklveklkvklkkywpeenf..eeyGrlivtleeeeeledyiirklklnkkssevet....RevkhfqyteWpdhdvPeka

HGIIKFIRQIN-SVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMAS
 ........|. |.   | ||| |||||||||||| ..||  .....||  . ...||  || |||..||  .||.|.| |||.  ..|.|.| .. .  
tslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrd

AIESLKR-KPNEGKCKLEVEF
 . .|.  ... |. .|| ||
rlkqlaekvadtgetgleref
DSPc_SM00195 894-1155 1.4e-92 305.1 In-house 3-260 (263) alignment 
Range on Protein: 894-1155
Range on HMM: 3-260/263.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
 .|.| | .  |...|.... |.|  |||| .|. ||.|||||  ... ...||||||.. |....||.|..|||..||..|||||.||.. .||||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTG-DYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGP
 || .| ||..||||.  ....||.| ||. .. |.  ..| |||...|..      |. |..|||.| .|.|  .|.... .....|.... .| . ||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|.||||||||||||.|..|.....||||. |.| ..|. ||.||  .||.|.||.|.|.|.|.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 894-1155 1.4e-92 305.1 In-house 3-260 (263) alignment 
Range on Protein: 894-1155
Range on HMM: 3-260/263.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
 .|.| | .  |...|.... |.|  |||| .|. ||.|||||  ... ...||||||.. |....||.|..|||..||..|||||.||.. .||||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTG-DYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGP
 || .| ||..||||.  ....||.| ||. .. |.  ..| |||...|..      |. |..|||.| .|.|  .|.... .....|.... .| . ||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|.||||||||||||.|..|.....||||. |.| ..|. ||.||  .||.|.||.|.|.|.|.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0046845 (Phosphotyrosine protein) phosphatases II 892-1156 6.6e-92 303.2 In-house 1-273 (284) alignment 
Range on Protein: 892-1156
Range on HMM: 1-273/284.0
GFLREYEMLPNRFSDR--TTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL-QTTDYINANFVIGY-----KERKKFICAQGPMESTIDDFWRMIWEQ
|. .|.|.|.. . ..  ... . |.||  ||||.|| .||..|||| ...|  ...|||||..| ||     . .||||..|||...|..|||||.|||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

HLEIIVMLTNLEEYNKAKCAKYWPEKvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN
. ..|||||.|.|... |||.|||..  .....||. |..  | . .||. ||| ....    | ..  |..|..||..| |. .|..|  ...|.|...
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl....gytgesrtvthfhytswpdhgvppspedlleflrlvr

SVYS--LQRGPILVHCSAGVGRTGTLVALDSLIQQLEEED---SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
....   . |||.||||||||||||..||| |..|||.|.    |.....|. || ||.. ||.| ||.|.|.|||. 
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley
0047943 (Phosphotyrosine protein) phosphatases II 885-1154 8.3e-92 302.8 In-house 6-269 (273) alignment 
Range on Protein: 885-1154
Range on HMM: 6-269/273.0
RHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLavinGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQH
....  ...|.|.|.|.. . . |.. . |.||  ||||.|| .||..||||    | ...|||||..| ||.  .|||..|||...|..|||||.|||.
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

LEIIVMLTNLEEYNKAKCAKYWPEKVFD-TKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN
 ..|||||.|.| .. |||.|||... . ....|.. |..  | . .||. ||| .....      .. |..|..||..| |. .|...  ...||....
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.....tgesrtvthfhytgwpdhgvppslesllefielvr

SVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
....   . ||..||||||||||||..||| |..|||.|  |.....|. || ||   ||.. ||.|||.|||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 877-1155 2.6e-89 294.9 In-house 18-287 (297) alignment 
Range on Protein: 877-1155
Range on HMM: 18-287/297.0
DLENAYKNRHKDTDYGFLREYEMLPNRFSDrtTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL-QTTDYINANFVIGYKE-RKKFICAQGPMESTID
 |. ... ....  ...|.|.|.|.. . |  .. . |.||  ||||.|| .||..|||| ...|    .|||||..| ||.   .|||..|||...|..
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMIWEQHLEIIVMLTNLEEYNKaKCAKYWPEKVFdtkQFGDILVKFAQERKTGDYIERTLNVSKnkanvGE-EedrRQITQYHYLTWKDFMAPEHPH
|||||.|||. ..|||||.|.|... |||.||||..    ..||. |.. .. . ..|. |||.|..     .. .   |..|...|. | |. .|... 
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.....nges...rtvthfqytgwpdhgvppsle

GIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
 ...|.........   . ||.|||||||||||||..|.. ...|||.|  |.....|. || ||.  ||.. ||.|||.|||.
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_PTPRA_pd Subfamily PTPRA 862-1179 2.9e-89 294.2 In-house 6-317 (330) alignment 
Range on Protein: 862-1179
Range on HMM: 6-317/330.0
SGNHKGFdagPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKK
|||.| |   |.   .||.  . |  |    |  |.. ||    . | . .. .||  |||...|  || .|| |.|..| ...||||| |. ||||..|
sgnkkyf...plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdk

FICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTkqFGDILVKFAQERKTGDYIERTLNVSkNKANVGEEEDRRQITQYHYL
|| |||| | |..|||||||||.   |||||.|.| .. |||.|||..   |  .|.| |.  .|  . ||  | . |  ....  .|.. |...|.|. 
fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt..yGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhft

TWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGN
.| |.  | .| |..|........   . ||| ||||||||||||...||....... |  | ....|  || ||  .||...|| |.|..||.   .|.
swPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd

TDICIDTMASAIESLKRK
|.. . .. . ...|. |
teldvsslekhlqklynk
0043336 (Phosphotyrosine protein) phosphatases II 873-1154 4.1e-89 294.0 In-house 2-274 (278) alignment 
Range on Protein: 873-1154
Range on HMM: 2-274/278.0
IHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSdRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMEST
|.. ||..|.......  ...|.|.| |.. .   |.. . |.||  ||||.|| .||..|||| ...|   .|||||..| ||.  .|||..|||...|
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

IDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPekvFDTKQFGDILVKFAQERKTGDYIERTLNVSKnkanvGEEEDRRQITQYHYLTWKDFMAPEHP
..|||||.||.. ..|||||.|.|... |||.|||    .....||. |..  | . .||. |||.|..       .   |..|.|||| | |. .||..
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.....lgdgesrtvthyhylgwpdhgvpesl

HGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
  ...|......... . ||.|||||||||||||..||. |..||| |  |.....|..||.||   ||.. ||.|||.|||
sllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 872-1154 4.9e-89 294.3 In-house 8-301 (307) alignment 
Range on Protein: 872-1154
Range on HMM: 8-301/307.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFS--DRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL-QTTDYINANFV--------IGYKERK
.| .|.|. ... ...|  .|.|.|.|.|..       ... . |.||  ||||.|| .||.||||| ...|  ...|||||..|         ||.  .
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

KFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHY
|||..|||...|..|||||.|||. ..|||||.|.|... |||.|||..  .....|.. |..  | . ..|. |||.|. .    ....  |..|..||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl....dgtgesrtvthfhy

LTWKDFMAPEHPHGIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDS---VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
..| |. .|...  ...||........   . ||.|||||||||||||..|.. ...|||.|     |.....|. || ||   ||.. ||.|||.|||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_PTPRG_pd Subfamily PTPRG 884-1168 1e-88 293.0 In-house 12-298 (563) alignment 
Range on Protein: 884-1168
Range on HMM: 12-298/563.0
NRHKDTDYGFLREYEMLPNRFSDR--TTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTT-DYINANFVIGYKERKKFICAQGPMESTIDDFWRMI
. | |.| || .|.| | ..  ..  ... |. .||  |||| .| |||..||||. . | . . ||||||.. ||.  |.|| .|||...|.|||||||
slhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmi

WEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEE-EDRRQITQYHYLTWKDFMAPEHPHGIIKFI
|||. .||||.|||.| .. ||  |||.   .....| . |.  .| ..  | .||| . . | . ... .. ....|||| .| |  .|||.   ..|.
WeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifv

RQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDT
.. .     . |||.||||||||||||...||.|..|...|..| .....  .| |||||||.  |||||. |||.. . ..|..  . 
kkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 884-1155 7.1e-88 289.4 In-house 14-277 (288) alignment 
Range on Protein: 884-1155
Range on HMM: 14-277/288.0
NRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQ
. ....  || .||. |..  ...... . | .|| ||||..| .||..||||   .  ...|||||... |.|..||.|..|||. .|..|||....|.
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

HLEIIVMLTNLEEYNKAKCAKYWPEKVfDTKQFGDILVKFAQERKTGDYIERTLNVSknkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN
. . |||||.| | .| || .|||..  . |..|.. |.  ......|...|.| .         ......||||.||.| |   ||  . .....||..
ktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkllle.......kkkteleitqyqylaWpdhgvPeskapllellrqvk

SVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
   . . |||.|||||||||||| .||| ||...|||| . . .||. ||.||..||| ||||.|.|..||.
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
Y_phosphatase Protein-tyrosine phosphatase 917-1154 4e-86 283.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 917-1154
Range on HMM: 1-234/235.0
NACKNRYPDIKAYDQTRVKLaviNGLQT-TDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQ
|  ||||.|| .||.|||||   .| .. .||||||.| |||| ||||..|||..|||.|||||.|... ..|||||.||| .. |||.||||.  ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVKFA-QER-KTGDYIERTLNVSKNKANVgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSL
.||| |.   .|  .. .|. |.|...|.|..     ..|...|.|| .|.|  .||.|......||....  . ..||..||||||||||||.|||| |
ygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

IQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
..|||.|..|.....|. ||.||. .||||.||||||.|.|
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 917-1154 4e-86 283.6 In-house 1-234 (235) alignment 
Range on Protein: 917-1154
Range on HMM: 1-234/235.0
NACKNRYPDIKAYDQTRVKLaviNGLQT-TDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQ
|  ||||.|| .||.|||||   .| .. .||||||.| |||| ||||..|||..|||.|||||.|... ..|||||.||| .. |||.||||.  ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVKFA-QER-KTGDYIERTLNVSKNKANVgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSL
.||| |.   .|  .. .|. |.|...|.|..     ..|...|.|| .|.|  .||.|......||....  . ..||..||||||||||||.|||| |
ygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

IQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
..|||.|..|.....|. ||.||. .||||.||||||.|.|
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 879-1178 3.1e-82 271.2 In-house 10-304 (305) alignment 
Range on Protein: 879-1178
Range on HMM: 10-304/305.0
ENAYKNRHKDTDYGFLREYEMLPNRfsDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWR
..  |. ....| |.  .|..|...  . ...    ..|. |||. .|  .|. |..|.  . |. .|||||..| |||..||.| ||||...|..||||
aayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWr

MIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKF
.|.| . . |||||.| | .| || .||||.. ..|.||.. |.  .|... ||||| |..|...     ... |...||.  .| |   |. .  ....
liveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede....dkesrtvlqyqltdWPdhGvpqfatsllsl

IRQINSVYSLQRG-PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLK
|....  .. ..| |.||||||||||||. .|.|  ...|..|..| ... .  ||..|  .||.|.|| ||. || .  | |.|.| .. .  ... ||
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk

R
.
k
0040439 (Phosphotyrosine protein) phosphatases II 910-1154 6.8e-82 270.1 In-house 4-243 (249) alignment 
Range on Protein: 910-1154
Range on HMM: 4-243/249.0
KNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEk
. . |.||  ||||||| .||..|||| ...||  .|||||... ||.  ..||..|||...|..|||||.||.. ..|||||.|.|... |||.|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

vFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTL
  .....||. |.. .. . .||. ||| ....     .. . |......|. | |. .|...  ...||........   . ||.|||||||||||||.
.ggsleygdftvtllsvevkddytvrtleltnl.....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

VALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
.|.. ...|||.|  |.....|..||.||.  ||.. ||.|||.|||
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 878-1174 1.8e-81 268.9 In-house 21-308 (319) alignment 
Range on Protein: 878-1174
Range on HMM: 21-308/319.0
LENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKN-SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDF
.. . |.  .|    .  |.  ....  . .... ..|..|  |||. .| |.|...|||  ..| . .||||| || ||. ..|.| ||||.. |..||
qqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladf

WRMIWEQHLEIIVMLTnleeynKAKCAKYWPEKVFDTKQFGDILVKFAQERKTgdYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGII
||||||..   ||.||      | ||..||| |.  ... ... |.  .| .   |. | ...|..    |.|.| |.|||.|.| | |   |..|  ..
Wrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsed....gkekdirkitqfhflGwpdvGvpdypsdlm

KFIRQINSVYSLQ--RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIE
....... . | .  | .|.|||||||||||. ..|| |.....||. | .||.| ||| ||| |||.| || |.| |||.   ||..|...  . . .|
rlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 880-1155 1e-80 265.9 In-house 4-274 (281) alignment 
Range on Protein: 880-1155
Range on HMM: 4-274/281.0
NAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRM
.  |..... . || .||| | .   | |.. |  .||  |||| .| |||.||||..  .  ..||||||||| |||. |..| .|||. .....||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFdTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFI
.|||. ..|||.|.  | .| || .|||..   . ..||. ||. .|...  ||||.........      . |...| .|..| |  .|. .. ...| 
vweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresg......etreveqlaytaWPdhGvPattkellefr

RQINSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQLEEE-DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
...... . ..  |...||||||||||| .||| |....|.|  .... ..| .||..||..||.. || |.|.|.||
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 886-1164 5.3e-80 263.8 In-house 22-297 (298) alignment 
Range on Protein: 886-1164
Range on HMM: 22-297/298.0
HKDTDYGFLREYEMLPNRFS---DRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWE
.| .  |.  |.. | .  |   . ... .  .||  ||||.|| |.|..|| |  ... . .||||| |. .||.|. || .|.|...|. |||||..|
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

QHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQI
.. . ||||||||| .| |. ||||..   ....|.| |.  .. . .|.| |.|.|||.|     ||..|.. | |. .| |  .||. . .....|..
edigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkk.....eekerevrqlhftsWpdkgvpenatsvldllrkv

NSvYSLQRG--PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDI
.  .  | |  |..|.|||||||.|| .|.||.......| .| ....|  ||..|  .||. .||.|.| | |.  . .|..|
ra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 896-1177 8.7e-80 263.2 In-house 3-275 (284) alignment 
Range on Protein: 896-1177
Range on HMM: 3-275/284.0
EYEMLPNRFSDRTTKN-SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTnl
|.  ....  . |... ..|..|  |||. .| |.|...|||  . | . .||||| |. ||. ..|.| .|||.. |..||||||||..   ||.||  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

eeynKAKCAKYWPEKVFDTKQFGDILVKFAQERKTgdYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQ--RGP
    | ||..||| |.  ... ... |.  .| .   |. | ...|..    |.|.| |.|.|.|.| | |   |..|  ......... . | .  | .
....kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsed....gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhran

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLK
|.|||||||||||. ..|| |.....||. | .||.| ||| ||| |||.| || |.| |||.   ||..|...  ... .| | 
ivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
0042113 (Phosphotyrosine protein) phosphatases II 914-1154 1.2e-79 262.4 In-house 6-240 (245) alignment 
Range on Protein: 914-1154
Range on HMM: 6-240/245.0
LKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvFDT
|.||  ||||.|| .||.||||| ...|   .|||||..| ||.  .|||..|||...|..|||||.||.....|||||..||... |||.|||.   ..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

KQFGDILVKFAQERKTGDYIERTLNVSKNkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYS-LQRGPILVHCSAGVGRTGTLVALDS
...||. |..  | . .||. |||.|...      .   |....|||| | |. .|...  ...|.. ......  . ||.|||||||||||||..|.. 
ltygdftvtllseehlddytvrtlevtnl.....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

LIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...|||.|  ||....| .|| ||   ||.. ||.|||.|||
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 887-1155 1.7e-79 262.4 In-house 3-270 (278) alignment 
Range on Protein: 887-1155
Range on HMM: 3-270/278.0
KDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKlavinglqttDYINANFVIGYkeRKKFICAQGPMESTIDDFWRMIWEQHLE
.. .. .| |.| |.  ..  .  .. . .|. ||||.|| .||..|||          |||||... ||  .||||..|||..||..|||||.||.. .
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

IIVMLTNLEEYNKAKCAKYWPEkvFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEdRRQITQYHYLTWKDFMAPEHP--HGIIKFIRQINS
.|||||.|.|... |||.||||   .....||. |.. .|  ..||. |||.|     .  . |  | .|..|||.| |. .|..|    .......|..
vivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefire

VYSL-------------QRGPILVHCSAGVGRTGTLVALDSLIQQLeeEDSVSIYNTVCDLRHQRNF-LVQSLKQYIFLYRALLD
...|             . ||.||||||||||||||||.. ....|  |. |.....|. || ||..  ||.| ||.|||..||.
alkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPRK_pd Subfamily PTPRK 888-1191 1.7e-78 258.6 In-house 19-312 (314) alignment 
Range on Protein: 888-1191
Range on HMM: 19-312/314.0
DTDYGFLREYEMLPNRfSDrTTKNsdlKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEI
   ||| .||| |..   | ..|.   .||  |||. || |||..||.| .|.| . .|||||... .||  ..|| .|||...|. ||||......   
aegygfkeeyeslfeg.wd.aakk...denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencas

IVMLTNLEEYNKAKCAKYWPEkvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYS
|||||.| |  . || |||||   ||...||| |.. .     ... |...|.| .      |..|.. |...|.| |.  | . .|..|..|....   
ivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklar...gqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqe

LQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-KRKPNEGKCK
 . |.|.|||||| ||||| .|.|.... .|.|. | ..|.| .|| ..  .|.  .||.|.| ..|..   |.| | .  . ..  .  .  |.    .
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssq

LEVEF
|. ||
lkeef
subfamily_PTPN9_pd Subfamily PTPN9 889-1155 5.4e-75 247.2 In-house 14-288 (297) alignment 
Range on Protein: 889-1155
Range on HMM: 14-288/297.0
TDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEII
   |  .||. . |.    | ..| |. |  |||| |.  ||.|||.|| ... ...|||||||| |||..| || .|||.. |..|||||.|||.  .|
gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN---SV
|| | ..|  . ||..|||..  ....|||. |.  . ... || .|.|.... |     .|. |..| . .|.| |.  |.  . ........    ..
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.....teesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

Y----------SLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
            ..  ||.||||||.|||||...||  ...|||.. | . .||  || || | .|  .|| | | |.|.
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN12_pd Subfamily PTPN12 908-1155 6.6e-75 246.7 In-house 31-275 (290) alignment 
Range on Protein: 908-1155
Range on HMM: 31-275/290.0
TTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
.|.... .||  |||| ||  ||..||.|  |.. .  |||||||. | ......| ||||.  |.|||||||||...||.||. .. | .| ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

EKVFDTKQFGDILVKFAQERKTG-DYIERTLNVSKNkanvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGT
|.. .. .||.. |.  .|...  |.. |||.| ..       ...|...|.||  | |   |. .. ....|...... . .  |..||||||||||||
eegeeelefgefevtleeekavdddflirtLkveaq.......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGt

LVALDSLIQQLEEED---SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
..|.|   ..|..|    ...... | .||.||. |||. .|| ..|.|...
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0050432 (Phosphotyrosine protein) phosphatases II 1181-1452 1.1e-74 246.8 In-house 38-300 (308) alignment 
Range on Protein: 1181-1452
Range on HMM: 38-300/308.0
NEGKCKLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILtplpmRENSTYINASFIEGY--DNSETFIIAQDPLENTIGDFWRMISE
  .. .|| |||.||.. .  . ..||.. .||  |||.  |.|||..||.|      |.|.|||||.. ||  ... .||..| ||.||..|||||. |
aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

QSVTTLVMISEIGDGP-RKCPRYWAD----DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYN
| |.. ||. .. .    ||..|| .    . ..|... |.... |....||.|....||.. .....||.|.| .||  |. ||.  . ........ .
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrk

HYKNnknsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
....       .|  |||| |  |.  |.|. .|...|. |..||.. . .|||.|| | .... ||.||.||.. |  
slpg.......gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0051299 (Phosphotyrosine protein) phosphatases II 1161-1450 1.3e-74 246.6 In-house 2-285 (288) alignment 
Range on Protein: 1161-1450
Range on HMM: 2-285/288.0
NTDICIDTMASAIESLKrkpNEGKCKLEVEFEKLLATADEisKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFII
.|.| .. ...... |.     |...|. |||.||.       ..|..  .||  |||.. |.|||..||.|..|.  |.|.|||||.|.||... .||.
dteisveellklvlkll...angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

AQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWA-DDEVQYDHILVKYVHSESCPYYTRREFYVTNC----KIDDTLKVTQFQYNGWPtvD
.| ||.||..|||||. || |.. ||. .. .   .||..||  .. ..|..| |.... |....|| |...|||.    . . ...||.|.| .||  |
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..d

GEVPEVCRGIIELVDQAYNHYKnnknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
  ||.  . ..... .......      . .|  |||| | .|.  |.|. .|...|. |..||.. . ..||.|| |....  ||.|...|.. |
hgvpdspellldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0037934 (Phosphotyrosine protein) phosphatases II 912-1154 5.1e-74 244.1 In-house 5-239 (243) alignment 
Range on Protein: 912-1154
Range on HMM: 5-239/243.0
SDLKENACKNRYPDIKAYDQTRVKLaviNGlqtTDYINANFVIGYKerkKFICAQGPMESTIDD----FWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
. |.||  ||||.|| .||..||||   .|   .||||||.. ...   ..|. |||...|..|    ||||.||.. ..|||||.|.|... |||.|||
allpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

ekvfDTKQFGDILVKFAQERKTGDYIERTLNVSknkaNVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV--------YSLQRGPILVHCSA
    .....||. |.. .|. ..||. ||| ..    |.....  |....|||| | |. .|..|  ...|.......        .  . ||.||||||
....gevtygdftvtllseehlddytvrtllle....nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GVGRTGTLVALDSLIQQLeeedSVSIYNTVCDLRHQRNF-LVQSLKQYIFLYRALL
||||||||.|.. ....|    .|.....|..|| ||..  ||.. ||.|||.|||
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPRD_pd Subfamily PTPRD 1204-1451 1.7e-73 243.2 In-house 39-281 (564) alignment 
Range on Protein: 1204-1451
Range on HMM: 39-281/564.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWA
.... ....| .||| ..|..||..||.|....  |.| |||||||.||......| .| ||..|| |||||. || ..| ||.... .  . || .|| 
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

DD-EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKnnknsGCRSPLTVHCSLGTDRSSIF
.. . .|... |. ...|   .|. |.| ... | ... .|.||..  ||  |  |||  .....|...  .. .       . |..|||| |  |. .|
ekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWP..dhgvpesatslLdlirkvralne.....pdagPivVhCSaGVGRTGtf

VAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
... .... .. || |||  . ..||.||  .. .  || |.|.|| .. 
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
DSPc_SM00195 1187-1450 2.5e-73 242.0 In-house 2-261 (263) alignment 
Range on Protein: 1187-1450
Range on HMM: 2-261/263.0
LEVEFEKLLATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVM
|. |||||.. . .   ... .| ..|. |||...|.|||..||.|.. . .|.|.||||..|.|.......|..| ||..|. |||||..|. |.. ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ISEIGD-GPRKCPRYWADD---EVQYDHILVKYVHSESCP-YYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNNkns
..|  . | .|| ||| ..   . ....| || |. |...  ...|.. .|... ..| ||||.||..||    .||.  . ..||. .........   
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts...

gcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
   .|. |||| | .|. .||.. |....|. || |||... ..||.|| |.... .|| |...||..|
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1187-1450 2.5e-73 242.0 In-house 2-261 (263) alignment 
Range on Protein: 1187-1450
Range on HMM: 2-261/263.0
LEVEFEKLLATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVM
|. |||||.. . .   ... .| ..|. |||...|.|||..||.|.. . .|.|.||||..|.|.......|..| ||..|. |||||..|. |.. ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ISEIGD-GPRKCPRYWADD---EVQYDHILVKYVHSESCP-YYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNNkns
..|  . | .|| ||| ..   . ....| || |. |...  ...|.. .|... ..| ||||.||..||    .||.  . ..||. .........   
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvpdstksvlellravkksksts...

gcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
   .|. |||| | .|. .||.. |....|. || |||... ..||.|| |.... .|| |...||..|
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 915-1155 4.7e-73 240.5 In-house 7-240 (250) alignment 
Range on Protein: 915-1155
Range on HMM: 7-240/250.0
KENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAkCAKYWPEKVfdTK
 .|  |||| || |.|..|| |   .| . .||||| |. ||.||| || .|||...|| |||||..|.. . |||||||.| .|  . .||| ..  ..
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..ae

QFGDILVKFAQERKTGDYIERTLNVSKNKanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL-QRGPILVHCSAGVGRTGTLVALDSL
..||..|.  .. . .||. |.| .||.|     ..|.|.. |.|...| |   ||. . ..........     . .|..|.|||||||.|. .|.|..
kyGdvtvsllskeefadytkrklklskak.....kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

IQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
...|..|  | ... .  ||..|   |.||.||.|.|...| 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
0046845 (Phosphotyrosine protein) phosphatases II 1187-1451 2.1e-72 239.2 In-house 2-274 (284) alignment 
Range on Protein: 1187-1451
Range on HMM: 2-274/284.0
LEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMR-ENSTYINASFIEGY-----DNSETFIIAQDPLENTIGDFWRMISEQS
|| |||.||     .. |.||.  .||  |||.. |.|||..||.|..|. . |.|.|||||...||     ... .||..| ||.||..|||||. || 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VTTLVMISEIGDGPR-KCPRYWA--DDEVQYDHILVKYVHSESCPYYTRREFYVTNCK-IDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYK
|...||. |. .  | ||..||   .. ..|... |.... | ...||.|....||..  . ...||.|.| .||  |  ||.  . ..|..... ....
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrelle

NnknSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK---CVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|   ... .|  |||| |  |.  |.|. .| ..|. |.   .||.. . ..||.|| | .....||.|...|...| 
n...lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 883-1153 2.8e-72 238.3 In-house 18-293 (306) alignment 
Range on Protein: 883-1153
Range on HMM: 18-293/306.0
KNRHKDTDYGFLREYEMLPNR-FSDR-TTKNSDLKENACKNRYPDIKAYDQTRVKLAvINGLQTTDYINANFVIG--YKERKKFICAQGPMESTIDDFWR
|.... .  ||  |.| | ..  ... . |... .||..||||  |  .|.|||.|.  .... .||||||.. .   ...|..| .|| .|.|. ||||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKqFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKF
|.|... ..|||.|.  | .| |||.|||..  ... .|.| |.  .|... ||| |.|.|||.     .... |.. |||. .| |   |..|  ...|
mvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk....kkkkeerevfqyhfksWPdhgvpkdpgavLdf

IRQINSVYSLQR----GPILVHCSAGVGRTGTLVALDSLIQQLEEED---SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
....|. ..  .    |||.||||||.|||||.. .| |....|..     . |...|  .|.||. |||  .|| |.|.|.
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 884-1191 4.6e-72 237.6 In-house 17-314 (315) alignment 
Range on Protein: 884-1191
Range on HMM: 17-314/315.0
NRHKDTDYGFLREYEMLPNRFSD--RTTKNSdlkENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
...  |  || ..|| .|       ...|..   ||  |||| .| |||..||.| ...  . .||.||||. ||. ....|.||||  ....||||...
qkkastkngfkqdyesipggqlhpldvakki...enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvf

EQHLEIIVMLTNLEEYNKAKCAKYWPEKvfdTKQFGDILVKFAQERKTGDYIERTLnvsknkaNVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQ
|...  ||||||| | .| |. ||||.|      .| | |   .| .  .|  |||        |  ... |.. |.|| .| |   |..   ....||.
eedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl.......svvfgdnirevvqlhytswpdmgvpkytiplmnlirt

INSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-KRKP
..     . |.|.||||||||||||...||....|.| |. . .|| .  .|..|  .||...|| |.| |||.|   |.| |. |      .||    |
vkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapsp

NEGKCKLEVEF
. |   |. .|
dtgstllqeqf
0047943 (Phosphotyrosine protein) phosphatases II 1181-1450 8.7e-72 237.2 In-house 8-271 (273) alignment 
Range on Protein: 1181-1450
Range on HMM: 8-271/273.0
NEGKCKLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILtplpMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQS
  |. .|. |||.|| . .  . ..||.. .||  |||.. |.|||..||.|      ..| |||||...||. . .||..| ||.||..|||||. || 
llgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VTTLVMISEIGDG-PRKCPRYWADD----EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHY
|...||. |. .   .||..|| ..    ...|... |...  |....|| |....||.. .....||.|.| |||  |  ||.    ..|..... ...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkal

KNNKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
......   .|  |||| |  |.  |.|. .|...|. |..||.. . ..||||| | . .. ||.||..|...|
ealpsn...gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0036941 (Phosphotyrosine protein) phosphatases II 1184-1451 1.9e-71 236.1 In-house 12-277 (297) alignment 
Range on Protein: 1184-1451
Range on HMM: 12-277/297.0
KCKLEVEFEKLlaTADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILtplpMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
. .|. |||.|  .   .. |.||....||  |||.  |.|||..||.|      |.| |||||...||| . .||..| ||.||..|||||. || ||.
lalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

LVMISEIGD-GPRKCPRYWA---DDEVQYDHILVKYVHSES--CPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKN
.||..|  . |  ||..||    .....|... |.... |.  ...||.|.. ||. . .....||.|.| |||  |  |||  . ........ ...|.
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp..dhgvpespaslldfielvrkvlkl

NKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQHLR---LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
  ..   .|  |||| |  ||  |.|. ...| |.    |..|||. . .|||.|| | . .. ||.||..|.... 
lpsg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 915-1197 7.9e-71 233.7 In-house 41-317 (515) alignment 
Range on Protein: 915-1197
Range on HMM: 41-317/515.0
KENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTK
. |  |||| .|  ||..|||| |||     ||.|| .. ...  | .|..||| ....|||||......   |.|.|.|.| .| ||.||||.|  |. 
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

QFGDILVKFAQERKTGDYIERTLNVSKNkanvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLI
.|| | |.       .. | |.|.| |.       .| | .||.|.  | |  .|.|   ..|.|... .  .    |...|||||||||| ....|| .
kfGsikvelvsleactggikrkltvlkg.......ddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvv

QQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKP-NEGKCKLEVEFEKLLAT
 . .. ..| ..|.|  .| .| .|||   || |.| |.|.   . || | .  ..  .. |.     .|. |.  ||. | . 
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlksl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 882-1193 9.3e-71 233.2 In-house 11-314 (315) alignment 
Range on Protein: 882-1193
Range on HMM: 11-314/315.0
YKNRHKDTDYgFLREYEMLPNRFSDRTTKNsDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
. |. . |   | .|.  ||.    |..     ..|  |||| .|  .|..|||| ||.     ||||| .. .... | .|..||| ....||||||..
fvnknrhtal.fseefhdlpdPdiyrqrva.retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvl

EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLnVSKNkanvgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQ
...   |||.|...| .| ||..|||..  |. .|| | |.  .   ..| . | | | ..       |. |..||...  | |  ....   ..|.|..
qekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk......seesrtvtqfqftewPdkGvdkqtssllklike

INSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKP-
. .    .  ..|||||||||||| ....|. ..|.....|| ..|.|  || .| .|||. ..| |.| |.|.   . || | .  ..  .. |.    
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd

NEGKCKLEVEFEK
 .|..|.  |||.
gsgrskmtkefet
subfamily_PTPN3_pd Subfamily PTPN3 894-1154 5.1e-70 230.6 In-house 18-272 (280) alignment 
Range on Protein: 894-1154
Range on HMM: 18-272/280.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAviNgLQTtDYINANFVI----GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIV
| ..|.|  .  ....... . ||. |||| || .||.|||||   .  .| ||||||.|     . .  ...| .|||...|  |||.|.|||. ..||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk..e.set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLTNLEEYNKAKCAKYWPEkVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQ
|||.| |  . || .||||   |. ..|.. ||  .|..|  |. | | .......     ..|.|.|  || | |   |.... ...|....... | .
mlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketk.....eerkilqlqylaWpdhgvPddsadflefvervrklrsgk

RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
. |..||||||.|||| |..|.  .. .|....| . . |  .| ||  |||. .|| |.  |.|
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0043336 (Phosphotyrosine protein) phosphatases II 1182-1450 8.3e-70 230.7 In-house 17-276 (278) alignment 
Range on Protein: 1182-1450
Range on HMM: 17-276/278.0
EGKCKLEVEFEKLLATADeisKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSV
 .| .|. |||.||        ..|... .||  |||.  |.|||..||.|..|. ...|.|||||...||. ...||..| ||..|..|||||. |. |
nlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

TTLVMISEIGDGP-RKCPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKnnkn
||.||. |  .    || .|| .. ..|... |...  |....||.| . |||.. . ...||...| |||  |..|||    ..... .. ....    
ttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreale....

sGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
  . .|. |||| | .|.  |.|. .|...|. |..||.. . ..||.|| | . .  ||.||..|.. |
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0040438 (Phosphotyrosine protein) phosphatases II 1184-1450 3.7e-69 228.8 In-house 17-275 (317) alignment 
Range on Protein: 1184-1450
Range on HMM: 17-275/317.0
KCKLEVEFEKLLATADEiskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
. .|. |||.||    .   ..||.| .||  |||.  |.|||..||.|.||. ...|.|||||...|.. . .||..| ||.||..|||||. || ||.
ftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

LVMISEIGDG-PRKCPRYWA-DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKnnkns
.||. |  .   .|| .||  .....|... |...  | ....| |.. |.. . .....||.|.| |||  |. ||.  . ........ ....     
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp..dhgvppspdllldfleavreale.....

GCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.  .|. |||| | .|.  |.|. .....|. |..||.  . ..||.|| | . ...||.||..|...|
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1160-1451 3.8e-69 228.2 In-house 1-290 (298) alignment 
Range on Protein: 1160-1451
Range on HMM: 1-290/298.0
GNTDICIDTMASAIESLKR-KPNEGKCKLEVEFEKLLATADEISKS-CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSET
|||.|  ...  |.. |.  |....  ... ||..| .. .|| .   .|....||. ||| ..||..|  ||.|.     |.|.||||||...|.....
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWAD-DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDG
||..| ||..|. |||||..|. ..|.||. .. .  . |...|| |  . .|..| |.  ..|.   .. |.. |.. | ... .| |...  ||  | 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWp..dk

EVPEVCRGIIELVDQAYNhykNNKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
 |||. . ...|...      .....|  .|..|.|| |..||  |.|.  ...... |. ||.  . . || .|.|.... .|| |.. |.... 
gvpenatsvldllrkvra...sqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
0045450 (Phosphotyrosine protein) phosphatases II 1175-1450 8.1e-69 228.0 In-house 17-303 (307) alignment 
Range on Protein: 1175-1450
Range on HMM: 17-303/307.0
SLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMR-ENSTYINASFI--------EGYDNSETFIIAQDPL
 ..... ... .|. ||||||   .... ..|... .||  |||...|.|||..||.|..|. . |.| |||||..        .|||.. .||..| ||
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

ENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWADD--EVQYDHILVKYVHSESCPYYTRREFYVTNC-KIDDTLKVTQFQYNGWPtvDGEVPEVC
..|. |||||. || ||..||..|  . | .||..|| |.  |..|... |...  | ...||.| . ||.. . . ...||.|.| |||  |. ||.  
petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp..dhgvppsf

RGIIELVDQAYNHYKNNKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKC---VDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
  ........ .........   .|  |||| | .|.  |.|. .. ..|. |..   ||.  . ..||.|| | . .. ||.||..|.. .
eelldfieevrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 883-1165 1.6e-68 226.0 In-house 21-292 (297) alignment 
Range on Protein: 883-1165
Range on HMM: 21-292/297.0
KNRHKDTdygFLREYEMLPNRFSDRTTKnSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKErkKFICAQGPMESTIDDFWRMIWE
|||| |    |  |.  ||.     .|. .. | |  |.|| .|  ||. |||||..|     ||.|| || |.|.  ..|. | ||..|..|||.|...
knrhtdv...fseeflclpeaniqpqtv.aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvld

QHLEIIVMLTNLEEYNKaKCAKYWPEKVFDTkqFGDILVKFAQERKTGDYIERTLNVSKNKANVgeeedRRQITQYHYLTWKDFMAPE--HPHGIIKFIR
..  .||||....| .| |||.||..|   |  |||. |.     .   .|.|.|.|.|.|| .     || . ||... | |   ..  . . ..|.| 
eqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkaka.....rrvvkqyqfveWPdkaverkdsassllklis

QINSVYSLQRG-PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDIC
... ..| .   |.||||.||||||| |...|| . . ..|..| |...|  ||..| .|||  .|| |.| |.|..    .|.| 
evrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 879-1192 2.1e-68 225.9 In-house 12-324 (325) alignment 
Range on Protein: 879-1192
Range on HMM: 12-324/325.0
ENAYKNRHKDTDyGFLREYEMLPNRfSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWR
|.  |.. .| | || .|...||.     . | . . ||  |||.... |.|..|| |   .    .|||||...  .|... |. || |. .||.|.||
ehvekkkaqdqd.gfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWr

MIWEQHLEIIVMLTNLEEyNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvGEeedRRQITQYHYLTWKDFMAPEHPHGIIKF
.. . .  ..|.|  |.. .| .||.|||... ..|.|| . ||.    .  ||. | |.| . |   ||    | . |... .|.|.  ...|  .| .
lvldWrcsvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk..Ge...trsvkqfqlqswddmGvqkrpatlisi

IRQINSVYSLQR------GPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASA
.. .. |    .      .||||||||||||||....| |..... || .| |.. |  ||..|  .|..  |||..| || ..   ||||. . .. . 
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IESLK-RKPNEGKCKLEVEFE
. ||. |.|   | ..| |||
lsslqernpltqklniekefe
0039614 (Phosphotyrosine protein) phosphatases II 1180-1450 3.8e-68 225.5 In-house 27-288 (297) alignment 
Range on Protein: 1180-1450
Range on HMM: 27-288/297.0
PNEGKCKLEVEFEKLLATADEisksCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMR-ENSTYINASFIEGYDN-SETFIIAQDPLENTIGDFWRMIS
.  .| .|. |||.||   ..    .|... .||  |||...|.|||..||.|.|.. . ..|.|||||...|||  . .||..| ||..|..|||||. 
kansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

EQSVTTLVMISEIGDGPRKCPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNckIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKN
|| ||..||. .  .  |||..|| ... .|... |...  | ...||.|.. |||   . ...||.||| |||  |. ||.  . ..|..... .....
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp..dhgvppslellleflelvrealae

NknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.   .   |  |||| | .|.  |.|. .....|. |..||.  . ..||.|| | . .  ||.||..|.. .
l...pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1164-1450 2.2e-67 222.3 In-house 2-279 (318) alignment 
Range on Protein: 1164-1450
Range on HMM: 2-279/318.0
ICIDTMASAIESLKRkpnEGKCKLEVEFEKLLATADEISKSCSvgENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQD
| .. ..| .. |..   .|. .|. |.|.|  . .....  |   .. |..||| . |..||. || |..|   |.| ||||..|.|| .....| || 
isvedleshvrrlre...sGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqa

PLENTIGDFWRMISEQSVTTLVMISEIG-DGPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVC
|| .|| |||||. ||  ...||....   | .|. ||| ...  .|... |.  .. .. .|. ||| ||. . ... .| |..|  ||  |  |||  
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWp..degvpesg

RGIIELVDQAYNHyknNKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 ....|| |. .    ...|| ..|..|||| |  |  .|.|. ||..... |. ||.  | ..||.||  ..    ||||.. .....
aslldlvrqvska...qqksg.agpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 896-1154 1.4e-66 219.4 In-house 10-265 (274) alignment 
Range on Protein: 896-1154
Range on HMM: 10-265/274.0
EYEMLPNRFsdrTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQT-TDYINANFVIGYKER-KKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
|.  ||  |   .... |.  .. |||| .|   ...|| |   .. .  ..|||||.. ||.|. | .. .|||. .|..||||||.... ..|||||.
eflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LEEYNKAKCAKYWPEKVFD--TKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeedRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVY---SL
|.| |..|||.|.|..     ....||. .|. .  .. ||  |.| ... .        .|... | |  | |  .|.... ..........     . 
lkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.......ersvkhywytdWPdhksPddantlldlvleveesreeena

QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...|..||||||.||||  .| .  ..||.||  | . ..||.|| .|  .||. .|| ...||| 
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 883-1155 1.2e-64 212.9 In-house 12-281 (290) alignment 
Range on Protein: 883-1155
Range on HMM: 12-281/290.0
KNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQ--TTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMI
 | |.  . ||  ...|| .  |. |..    ..|  .||. .|  ||. |. |  |.| .  | .|||| .. ||||.|..| .|||...|. |||..|
anghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

WEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIR
|...  |||||||  | .| || .|||..  |||..| . .|  .|... .||||.|.| .....    ......|||.  .|..    ..|..|.  |.
wqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsa....gakqsvtqyqitnwdstgkvtnpqtillvie

QIN-SVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
...   .   ...|.||||..|||.....|..  |.. . |  . ... .  .| |.  .||. .|| .... .| 
emyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
Y_phosphatase Protein-tyrosine phosphatase 1213-1448 3.6e-64 211.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 1213-1448
Range on HMM: 1-234/235.0
NNMKNRSQEIIPYDRNRVILTPLPMRENstYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQY
|  |||...|.|||..|| |.  . ...  ||||....||.....||..| ||..||.|||||. .. |...||. .  . | .||..||    .....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DHILVKYV-HSE-SCPYYTRREFYVTNCKIDD-TLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnknSGCRSPLTVHCSLGTDRSSIFVAMC
..| |... ...  .  || |.. ... | .. . .|.|..|..||  | .|||  .....|...  ..      . ...|..|||| |. |. .|||. 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp..dhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvald

ILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
||...|. |..||.. . ..||.|| |...|..||.||..||.
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1213-1448 3.6e-64 211.8 In-house 1-234 (235) alignment 
Range on Protein: 1213-1448
Range on HMM: 1-234/235.0
NNMKNRSQEIIPYDRNRVILTPLPMRENstYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQY
|  |||...|.|||..|| |.  . ...  ||||....||.....||..| ||..||.|||||. .. |...||. .  . | .||..||    .....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DHILVKYV-HSE-SCPYYTRREFYVTNCKIDD-TLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnknSGCRSPLTVHCSLGTDRSSIFVAMC
..| |... ...  .  || |.. ... | .. . .|.|..|..||  | .|||  .....|...  ..      . ...|..|||| |. |. .|||. 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp..dhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvald

ILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
||...|. |..||.. . ..||.|| |...|..||.||..||.
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1172-1450 2e-63 209.1 In-house 8-278 (288) alignment 
Range on Protein: 1172-1450
Range on HMM: 8-278/288.0
AIESLKRKPNEGKCKLEVEFEKLlaTADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGD
 ..  ..|  ...  .. |...|  .| | .|| ..|.. .|. ||| ..|.||| .|| |. |.  ... |||||.|.|.......| .| || .|..|
pvakvakksarnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRMISEQSVTTLVMISEI-GDGPRKCPRYWADDEV--QYDHILVKYVHSESCPYYTRREFYVTncKIDDTLKVTQFQYNGWPTVDgeVPEVCRGIIELV
||... |. ..|.||..|.  .| .|| .|| |..   .| .. |. |.|.    .. |.. .   |  . |..||.|| .||  .  |||  . ..||.
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhg..vPeskapllell

DQAYNHYKNNknsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.|  .  ...       |..|||| |  |. .|.|.  |..... |. .|...|  ||| ||. |..   ||||....... 
rqvkvanqad.....tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 917-1169 2.2e-63 209.2 In-house 48-291 (439) alignment 
Range on Protein: 917-1169
Range on HMM: 48-291/439.0
NACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKakcakYWPEKvfDTKQF
.  |||| |. |.| ||| |  | |.  . |||||.. || . | .| .||| . | |||||...|..   ||||||| |  |     ||| .  .   .
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcy

GDILVKFAQERKTGDYIERTLNVSkNKANVGEEEdrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYS-LQRGPILVHCSAGVGRTGTLVALDSLIQ
||| |.  .. .  .|. | ..|  |. . .| |  | . |.||..| |   | .   ...|.| |||     . ||..||||||||||||..|||  ..
gdiavrvdrnielpnyvirgfkvf.nerdtteke..rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale

QLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTM
||  |. | |   |  ||.||. .||.| ||.|.| |.|.   .|.. . || .
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 913-1154 2.8e-63 208.4 In-house 16-261 (270) alignment 
Range on Protein: 913-1154
Range on HMM: 16-261/270.0
DLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVF
.   ..  ||| ||    .|||.|. ..  ..| |||||.| |... .||.|.|.||...|. .|||||||.. . |||.|.||| .. ||..|||... 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

D--TKQFGDILVKFAQERKTGDYIERTLNVSkNKanvGeeeDRRQITQYHYLTWKDFMAPEHPH------GIIKFIRQI-NSVYSLQRG-PILVHCSAGV
.  . ..|.| |   .|.|.  || . |..  .|   |   ..|... ..| || |  .|...        ..| .|.. .|  .|... |.||||||||
ekvkledgkikvlalseekeegyiltrlrle.ek...g...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
||||||.|||  .. |||. .| . . . .||..|  |||  .|| |||.|..
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPRG_pd Subfamily PTPRG 1181-1449 4.2e-63 208.4 In-house 15-285 (563) alignment 
Range on Protein: 1181-1449
Range on HMM: 15-285/563.0
NEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENS-TYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQ
 .|. ... |||.|  .  . .  ..  ...||  |||  .|..||| || |.|||  ...  ||||..|.||  |. ||..| ||..|. |||||| ||
adgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

SVTTLVMISE-IGDGPRKCPRYWADDEV-QYDHILVKYVHSESCPYYTRREFYVTNCKID------DTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQA
 |...|||..   .| |||..||  ||. .|... |. ...|   .|| |.. . | |..      . ..|.|..|  ||  |  |||     .  | ..
nvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP..dhgvPehslpvLifvkks

ynHYKNNKNSGcrsPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
   . |... |   |..|||| |. |. .....  |.. .. |. |..  . ...|.||  |...  || ||| |...
..saankaeaG...PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_PTPN13_pd Subfamily PTPN13 896-1155 1.5e-62 206.3 In-house 16-267 (273) alignment 
Range on Protein: 896-1155
Range on HMM: 16-267/273.0
EYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGlqttdYINANFVI--GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
|.. | .  .  |.. .  |||  |||| ..  ||.|||||    |     ||||...     |.. ..| .|||.  |..|||.|.|||. |.|.|.|.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

LEEYNKAKCAKYWPEKVFDTKQFGD-ILVKFAQERKTGDYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGP
  | .| || .||||.  .. .  . . |.  .  |  ..  |.|.|.....     .. |.... .. .| |   | ..  ...|....... . ..||
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.....gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagP

ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|.||||||.||.|||...| ... .| . .. . ..| .||.||. .||. .|||| |.|.|.
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1186-1450 1.8e-62 206.3 In-house 23-282 (305) alignment 
Range on Protein: 1186-1450
Range on HMM: 23-282/305.0
KLEVEFEKLLATadeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV
.||.....|  .    ..|. ||..|.|. |||..||...| .|.|||. .  ..| |||||...||......|.|| ||.||. ||||.| |  |.|.|
gleaqykslyee....eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MISEIGD-GPRKCPRYWADDEVQ---YDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKN
|.... . |  || .||.. . .   .... |.   ... . |. |.. ...  . ...  |.|.|   ||  |  ||.    ...|...  ...|..|.
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWP..dhGvpqfatsllslikrvqkdqkkdkg

sgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
     ||.|||| |  |. .|.|. | ...|. |. ||.   ...|||.| ..... .|| ||| |. ..
....vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
0040439 (Phosphotyrosine protein) phosphatases II 1204-1450 4.3e-62 205.3 In-house 2-245 (249) alignment 
Range on Protein: 1204-1450
Range on HMM: 2-245/249.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWA
..||.. .||  |||.. |.|||..||.|..|| .. | |||||.|.||. . .||..| ||..|..|||||. |. .|..||...       || .|| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNknsGCRSPLTVHCSLGTDRSSIF
 .....|... |.... |....||.|....|| . .....|...|| .||  |  ||.    ........ ......   .. .|. |||| | .|. .|
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleel...pkggpvlVHCsaGvgRtGtf

VAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.|. .....|. |..||.  . ..||||| | . .. ||.||..|.. .
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 882-1161 4.8e-62 204.5 In-house 11-282 (287) alignment 
Range on Protein: 882-1161
Range on HMM: 11-282/287.0
YKNRHKDTDYGFLREYEMLPN--RFSDRTTKNSDlKENACKNRYPDIKAYDQTRVKLAvingLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRM
 .. |.  . ||   . .| .  .  |  | |   ..|  |||. .|  .|. || |      .  ||||| |. ||||.|.|| |..|| .|. .||..
vakghakgnegfknqftvleqvtqredevthnia.sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

IWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgEEEDRRQITQYHYLTWKDFM-APEHPHGIIKF
|.... ..||||....| .. .| .||||.  ..  .|.  ... .| .. .||||.|.| ...    ...|..|..||.. .|..    .|.   .. .
iddrnvtaivmlcqekendeevcyqyWpee..ksvvlGeyniellneevnagyierklevknkn....kagdkqqvkqyqitnWdstgkvtepqtillvi

IRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGN
 ... . .   ...|.||||..|||.....| .  |.. ..|  . ... .   | |.   ||  .||.|.. ..|   . ..
eemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1177-1453 5.8e-62 204.6 In-house 15-285 (319) alignment 
Range on Protein: 1177-1453
Range on HMM: 15-285/319.0
KRKPNEGKCKLEVEFEKLlATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMI
|.  . |. .|| ||..|  .|..   . .  ..|||. ||| |.|..||| ||.|..|.  |.|.|||||||.||.. | || .| |||||| |||||.
kalastgetllekefkll.keavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

SEQSVTTLVMISEIGD-GPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVtNCKIDD--TLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAY
 |. . ..||.... . .  |. .|| . . ..| ...|.  . |    |  |.. . | | ..  | .|..|||. ||  | .|||  .....|. .  
WeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWp..dhdvPekatslldllkrir

NHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
.  .....     |..|||| |  |   |... . ......|  .|.  | ..|| ||  ...  .||.|.. |.... . 
ksrektqs....gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPN23_pd Subfamily PTPN23 909-1155 8e-62 203.6 In-house 35-278 (288) alignment 
Range on Protein: 909-1155
Range on HMM: 35-278/288.0
TKNSDLKENACKNRYPDIKAYDQTRVKLAvingLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
.  .  | .. |||. ||  ||..||||      .. ||||| || .      .||..|.|..||. |||.|..||. ..||||.. || .| |...|||
rsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

EKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR----GPILVHCSAGVGR
|.  .|..|||. |   ..|.|. ..||.|... ..|     .  ....  .. .| .. .|. |. ...|. ...| |. ..     |..|||||||||
edkgetvkfgdlsvtlksvretethvervlkletlda.....davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

TGTLVALDSLIQQLEEEDSV-SIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
||..  . . ...||... .  | . |  ||.|| | ||  .|. |.| | | 
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPRB_pd Subfamily PTPRB 1176-1450 1.7e-61 202.8 In-house 16-284 (293) alignment 
Range on Protein: 1176-1450
Range on HMM: 16-284/293.0
LKRKPNEGKCKLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRM
.|.. .. ....  |.|.| |     ...... |...|. ||| ..|.||| .|| |..|  ...| ||||..|.||     || .| || .|. |||||
vkkmkadsdlrfseeyeelkavgk..dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrm

ISEQSVTTLVMISEIGD-GPRKCPRYWADD--EVQYDHILVKYVHSESCPYYTRREFYVTNckIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAY
. |. ....||. .. . |  || .|| .|  .|.| .| |. |..|.   .. ||. ...   ... ||.|...  ||  | .|||  . ....| .  
vwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWp..dhgvPektktlldfvrtvr

NHYKNNKNsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.. .....   ..|..|||| |  |. .|.|.  |.|... | .|||...  .||..|. |. . .|| |.|......
eaiektas...krPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_PTPRA_pd Subfamily PTPRA 1178-1450 2.4e-61 202.4 In-house 25-294 (330) alignment 
Range on Protein: 1178-1450
Range on HMM: 25-294/330.0
RKPNEGKCKLEVEFEKLLATadEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMIS
..  .   ..  ||. | |.  .|  .. . ..|||. |||  .|.||| .||||...   |.| |||||||.|| . ..|| || |.|.|. |||||| 
irsaddnklfreefnalPag..piqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

EQSVTTLVMISEIGD-GPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVT----NCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQA
||  .|.||..|. .    || .|| |.  | | .| |.  ... .  || |.| |.    ... ...  |.|| ...|| |   ||   .|...|. . 
eqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv..GvPfepiGmlkllkkv

YnhyKNNKNSGCrsPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
    | |..|.   |..|||| |. |.  |...  ... .. |. ||.  . ..|| ||. ....  ||||..... .|
k...klnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN14_pd Subfamily PTPN14 894-1154 6.7e-61 200.9 In-house 26-293 (300) alignment 
Range on Protein: 894-1154
Range on HMM: 26-293/300.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLqTTDYINANFV---IGYkERKKFICAQGPMESTIDDFWRMIWEQHLEIIVM
  ||| .|..  | ... . |.||| |||..|.  |...||.|.  .   .|.||||  .   .|  .....| ||||.| |. |||.|.|||....|||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvgg.kersyivaqgPleltvqdfWqmvWeqgvqlivm

LTNLEEYNKAKCAKYWPEK--VFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAnvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL
||. ||  | |. ||.|..    .| .||   |     .... .| ..|..    .     ...|..    |  | |   || ..| ........||   
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlps.....keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

---------QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
         .. |.|||||||||||| |.  | ||. || .... | ...  ||.|| .|||.| || |.|..|.
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPN1_pd Subfamily PTPN1 902-1166 2.2e-60 198.8 In-house 17-280 (290) alignment 
Range on Protein: 902-1166
Range on HMM: 17-280/290.0
NRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGlqttDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAK
.  || .|....|.||  .||| |.. || .|.||   .     |||||..|   . ....| .|||. .|.| ||.|.|||.   .||| .. | .. |
keasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CAKYWPEKVF-DTKQFG--DILVKFAQERKTGDYIERTLNVSKnkanvGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL--QRGPILVH
||.|||..   .. ..    . ||. .| ..  |. |.|.. .      . .. |.|...||.|| ||  || |   .||. .. .  ||  . || ..|
caqywPqgeeekellledtklkvkliseerksyytvrllelen.....lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRTGTLVALDSLIQQLEEEDS---VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICI
||||.||.||.. .|... ..|..|    | | .....||..|  |.|  .|  | | |.|.   . ..|  .
csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
0042113 (Phosphotyrosine protein) phosphatases II 1205-1450 4.5e-60 198.4 In-house 1-242 (245) alignment 
Range on Protein: 1205-1450
Range on HMM: 1-242/245.0
CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWA-
.||.. .||  |||. .|.|||..||.|.| . .. |.|||||.. ||. ...||..| ||..|..|||||. |. .||.||..|  .    ||..||  
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNnknsGCRSPLTVHCSLGTDRSSIFV
.....|... |...  |....||.|.. ||| . | ...|....| .||  |. ||.  . ...... . .....    .   |. |||| | .|.  |.
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp..dhgvpdllellldflefvrkalae....dsngpvlVHCsaGvgRtGtfi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
|. .....|. |..|..  . ..||||| | . .  ||.||..|....
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1175-1450 8.1e-60 197.8 In-house 24-290 (319) alignment 
Range on Protein: 1175-1450
Range on HMM: 24-290/319.0
SLKRKPNEGKCKLEVEFEKLLATADEISKScSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWR
| |.. .. . |||||| ..   . . ..  .  . ..|  |||  .|...|.|.| | .|   | | ||||||..|| . . .| || ||.||. ||||
snksdfdddltklevefrracklgvnladq.tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWr

MISEQSVTTLVMISeigdgPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAy
|| |. ..|.|...       || .||  .  .....  ||    | .  |. |.. ...  |  |  |.||| . ||| |   ||.    .. ||..  
miweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdv..Gvpdypsdlmrlvkkv.

NHYKNNKNSgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
.| .. .|   | .. |||| |. |. ..... .|.. .. || ||.  . | || ||  |.....|| |.. |... 
rhltskenh..ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPRK_pd Subfamily PTPRK 1206-1449 1e-59 196.9 In-house 36-275 (314) alignment 
Range on Protein: 1206-1449
Range on HMM: 36-275/314.0
SVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADD
 .  ..||..||||..|..||| ||.|...    .| ||||..|..| ... ||..| ||..|. ||||.. ..  ...||..|. .    || .|| .|
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

EVQYDHILVKYVHSESCPYYTRREFYVTN--CKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNnknsgCRSPLTVHCSLGTDRSSIFV
  .|..| |..|..|    .  | | |..   . ... .| |||. |||.   .||   .|...|| .  .. ..        .. |||| |. |. .|.
tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.....eaGrivvhCsaGaGrtGtfi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
|..|... .. |. ||.  . ..|||... ...   || |.. .|..
aidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0045098 (Phosphotyrosine protein) phosphatases II 1201-1450 1.5e-59 197.0 In-house 21-271 (278) alignment 
Range on Protein: 1201-1450
Range on HMM: 21-271/278.0
ISKSCSVGENEENNMKNRSQEIIPYDRNRVIltplpmrensTYINASFIEGYdnSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPR
|  .....  ..|  |||  .|.|||..||.           |||||.|.||  . .||..| ||..|. |||||. |. .|..||. | . .|  ||..
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNC----KIDDTLKVTQFQYNGWPtvDGEVPEVC--RGIIELVDQAYNHYKNNKNS--------GCR
|| ... ..|... |...  | ...|| | ..|||.    . . ...||...| .||  |..||.    . ..||...  ...|.  .         .  
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwp..dhgvpslpilksflellefirealkllaslllsslllldsg

SPLTVHCSLGTDRSSIFVAMCILVQHLrlEKCVDICATTRKLRSQRTG-LINSYAQYEFLHRAIINY
 |  |||| | .|.  .||. .. ..|  |. ||.  . ..||||| |  . .  ||.||..... .
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1206-1452 9.9e-59 193.5 In-house 2-243 (250) alignment 
Range on Protein: 1206-1452
Range on HMM: 2-243/250.0
SVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWA-DD
||... .|. |||  .||..|  ||.| .    ..| ||||||..|||....||..| ||..|| |||||. |. ..|.||.... .  .....||  . 
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek

EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNhykNNKNSGcRSPLTVHCSLGTDRSSIFVAM
  .| ...|.   .|    || |.. ... |  |   | |...  ||  |  |||| . ..||...      .....|  .|. |.|| |. ||  |.|.
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWP..dkgvPevatavLellkkvqa...sqqqag.naPvivqCsaGvgrsGafiai

CILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
  ....|. || ||.    ..|| .| . ..| .|| |....|... |
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_CG7180_pd Subfamily CG7180 893-1155 4.4e-57 188.0 In-house 19-288 (296) alignment 
Range on Protein: 893-1155
Range on HMM: 19-288/296.0
FLREYEMLPNrFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLT
.  |... |. ..  . .    |||  |||....  ||..|| |  ..| ...||||| .| ..   |..|  ..|...|.|.|||...... . .|.||
yklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

NLEEYNKaKCAKYWPEKVfdTKQFGDILVKFAQERKTGDYIERTLNVSKN-----KANVGEEEDRRQITQYHYLTWKD-FMAPEHPHGIIKFIRQINSVY
.  ...| .. .|||.|    .|.|.|.|.  .|..  .   ||. . |.     . . ... . | ...... .|.     |    ..|...|..... 
ktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

SLQ-----RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
        .||..|..| |..|.|  .|.|  ....|.|. | ... |  ||..|. ||.. ..| ..|  ||.
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1209-1451 4.5e-57 188.7 In-house 21-255 (284) alignment 
Range on Protein: 1209-1451
Range on HMM: 21-255/284.0
ENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISeigdgPRKCPRYWADDE-VQ
. ..|  |||  .|...|.|.| | .|   | | |||||||.|| . . .| .| ||.||. |||||| |. ..|.|...       || .||  .  ..
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivik

YDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAyNHYKNNKNSgcRSPLTVHCSLGTDRSSIFVAMCI
...  ||    | .  |. |.. ...  |  |  |..|| . ||| |   ||.    .. ||..  .| .. .|   |... |||| |. |. ..... .
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdv..gvpdypsdlmrlvkkv.rhltskenh..ranivvhcsagvgrtgvyivldv

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|.. .. || ||.  . |.|| ||. |.....|| |.. |...  
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
0037934 (Phosphotyrosine protein) phosphatases II 1205-1450 6.1e-57 188.3 In-house 2-241 (243) alignment 
Range on Protein: 1205-1450
Range on HMM: 2-241/243.0
CSVGENEENNMKNRSQEIIPYDRNRVILtplpmrENSTYINASFIEGYDNsetFIIAQDPLENTIGD----FWRMISEQSVTTLVMISEIG-DGPRKCPR
.|..  .||  ||| . |.|||..||.|      |.| ||||..|.....   .|. | ||..|. |    ||||. |. .|..||. |    |  ||..
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWAdDEVQYDHILVKYVHSESCPYYTRREFYVTNCK-IDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKN-----NKNSGcrSPLTVHCSL
||  .||.|... |.....|....|| |.....|..  | |. |....| .||  |. ||. .  .....|........     . .||  .|. |||| 
ywp.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp..dhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsa

GTDRSSIFVAMCILVQHLrlekCVDICATTRKLRSQRTG-LINSYAQYEFLHRAIINY
| .|.  ..|. .. ..|    .||.  . ..||.|| |  . .. ||.||..|.. .
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 916-1154 1.6e-55 182.9 In-house 2-236 (237) alignment 
Range on Protein: 916-1154
Range on HMM: 2-236/237.0
ENACKNRYPDIKAYDQTRVKLAVINGLqtTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVfDTK
||  |||| .|.|||..|| |    .   .|||||... |.    ||.|.||||.||. ||||.|.|...  .||||| | | |. || ||||.   . .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpa

QFGDILVKFAQERKTGDYIERTLNVSKNKANVgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN--SVYSLQRGPILVHCSAGVGRTGTLVALDS
 .| . | . .. .  ||  |.| .||.        . | | ||.. .| |   |..   ...| ..|   | .  . || ..|||||||||| .. .|.
aygvltvslkkkeefsdytvrslllskrltlk....evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida

LIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...| .|.  | ||| |  .  .| ...|.  ||.|.....|
mlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1182-1452 3.4e-55 181.9 In-house 17-284 (290) alignment 
Range on Protein: 1182-1452
Range on HMM: 17-284/290.0
EGKCKLEVEFEKLLAtaDEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMREN--STYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQ
.|. . . .|..| .   | ...  ||  ..|. .||...|..|| ||..| |.. ...    ||||..|.|| ... .|..| |..||. |||..| ..
kgnegfrnqfkmlds..gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

SVTTLVMISE-IGDGPRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNCKI-DDTLKVTQFQYNGWPTvDGEVPEVcRGIIELVdqaYNHYK
.|| .||. . | .|  ||  ||.| .  .|... .| .. |.. .|..|.. |.| .  ... .|||.|   |.  .|.|..   .|. ..   .. ||
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwds.tgkvtnp.qtillvi...eemyk

NNKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
... .| . .. |||| .  ||..|.|. . ... . |  .|. .  ...|.|. |....  ||..... ...| |
tqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 910-1154 3.5e-55 181.8 In-house 31-274 (287) alignment 
Range on Protein: 910-1154
Range on HMM: 31-274/287.0
KNSDLKENACKNRYPDIKAYDQTRVkLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEK
|...   .. |||| |.  .|.||| | . .| . .||||||.| .|.. ..||.||||. .|. ||||...|..   ....|   |  . || |||||.
kaaeelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

VFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR-----GPILVHCSAGVGRT
    .  |  .| . .. |  .|  |.| . . ...     . | . |...|.| |  ..    |.|.|. ...    |.|     ||..||...|.||.
evPmrvGGysvvlldydikePeygvralrlidletr.....earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrs

GTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
|.|.|.  |...||.   | . ..|  || .|. |||.  |. .|| || 
GillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1184-1452 1.1e-54 180.5 In-house 14-277 (281) alignment 
Range on Protein: 1184-1452
Range on HMM: 14-277/281.0
KCKLEVEFEKLLATadEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
.  .  |.||| |   ..... .  ...|| .||| . |. ||  || .||    .|. ||||.|..||.. . .|..| |. ... .||.|. ||.|..
naGfieeyeklaai..gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

LVMIS-EIGDGPRKCPRYWADDE--VQYDHILVKYVHSESCPYYTRREFYVtNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKN
.||.  ||  |  || ||| ||.  ..| .. || ...|. . | .|.| . . .  .| .|.|..|  ||  |  ||.  . ..|  .. ..  .....
ivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWP..dhGvPattkellefrkevlkltekktk

sgcrSPLTVHCSLGTDRSSIFVAMCILVQHLR-LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
     || .||| |  |.  ..|.  ||...   .. .|..|. ..|| .|. .. . .||||...|.... |
....aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPRN_pd Subfamily PTPRN 894-1153 9.1e-54 177.2 In-house 32-288 (297) alignment 
Range on Protein: 894-1153
Range on HMM: 32-288/297.0
LREYEMLPNRFSDRTT-KNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERK-KFICAQGPMESTIDDFWRMIWEQHLEIIVML
 .|.| | .  .. .| . .. ..|. |||. .. .||..||||   .  ...||||| ...    |.  .| .|||. ||. |||.|.|||   .||.|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

TNLEEYNKAKCAKYWPEKVFDTKQFGDILVkFAQERKTGDYIERTLNVsKnkaNVgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRG
|.||| .  .|..|||..  .. .. .. .  ..   . ||. |.. . |   |. . .. | .||.|.|.|..  .|  .. ...| |..|  |  .  
trleeegvkqckrywpdeGsevyhiyevhl.vsehiwcddylvrsfyl.k...nl.qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrsc

PILVHCSAGVGRTGTLVALDSLIQQLEE-EDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
||.||||.|.||||. ...| ....|      . |  |.  || ||. ||.. .|. | . |.
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 883-1178 1.4e-53 176.7 In-house 15-257 (392) alignment 
Range on Protein: 883-1178
Range on HMM: 15-257/392.0
KNRHKDTdygFLREYEMLPNRFSDRTTkNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWE
||||      |  |.  ||.    ..|  .  . |  |||| .|  ||..|||| ||.    .||.|| .. ...  | .|..|||  ...||||||...
knrhsal...ffeefhdlpgpdiypqt.vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfq

QHLEIIVMLTNLEEYNkakcakywpekvfdtkqfgdilvkfaqerktgdyiertlnvsknkanvgEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQI
..   |.|.|.|.| .                                                   .| | ..|.|.  | |   |.|   ..|||...
envttiamvtklkegd.................................................kgddartvaqfhftewPdkdvpkhtssllkfikev

NSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKR
.. .     |...|||||||||| ....||.. . ..   | ..| | ..|..| ..||. .|| |.| |.|.   . || | .  ..  .. |. 
kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 906-1169 3.4e-53 175.4 In-house 22-278 (283) alignment 
Range on Protein: 906-1169
Range on HMM: 22-278/283.0
DRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGlqttDYINANFVI---GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKC
|. .. .  .||  |||. .| ..|| ||.|   .     ||||| |..    ||. ||.| ||.|.. |. |||.|.....   |||||.| | .. ||
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

AKYWPEKvfDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGEEEDRRQITQYHYLTWkdfmAPEHPHGIIKFIRQINSVYSLQ----RGPILVHCS
..|||..   ....|.  |   .|     .| . | . .|    .  ..   .. | .  |        .  ||  . ..| | |||    .|||.||||
sqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvn....ssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCs

AGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTM
.|.|||....|. . ....  |  | ....|  .| ||  .||.| || ... . |.    |.|.|    .
tgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_PTPN9_pd Subfamily PTPN9 1209-1451 4.8e-53 175.1 In-house 38-290 (297) alignment 
Range on Protein: 1209-1451
Range on HMM: 38-290/297.0
ENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DD
.   |  ||| .... ||. || |. ..  |.| ||||.|..|| . ..|| .| ||..|. |||||. ||.| ..||.  . . | .|| .||    ..
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYK--------NNKNSGCRSPLTVHCSLGTD
  .. .. |. |. |.   |. | . ..| | ... ||| ||. .||  |  ||. .  ........ ..          ..|      |. |||| |  
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWP..dyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|.  |... | ...|. .  ||.. | ..||.||.  |    |||| . |...|.
rtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 884-1153 6.7e-53 174.3 In-house 11-289 (301) alignment 
Range on Protein: 884-1153
Range on HMM: 11-289/301.0
NRHKDTdygFLREYEMLPNRFSDRtTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGL--QTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW
. |...   |  .|. | .  ... .. .  .||.  ||. .|. ||. |. |.  . |  ....||||... ||.|.|||| |||||..|. ||||.||
akhsnk...feeqykelkegedks.ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVS----------KNKANVGEEEDRRQITQYHYLTWKDFMAPEH
...   |||.|||.|  |.|| .|||.   ....|| . |.. .|    |.. | |||           . | .| .. . ....|..   | .      
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

PHGIIKFIR-QINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
|. ... |  .|    .   ||..||||..|.|.|. ....  . |   |  | ... .  .|...   |. |.||...| ..
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_PTPN12_pd Subfamily PTPN12 1186-1451 9e-53 174.0 In-house 9-277 (290) alignment 
Range on Protein: 1186-1451
Range on HMM: 9-277/290.0
KLEVEFEKLLATADEIS----KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSV
... ||.|| .....       | ..||.|||  ||| ..|.||| .|| |.     |.| ||||.||.| ... ..| || || .|. |||||| |..|
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

TTLVMIS-EIGDGPRKCPRYWADD---EVQYDHILVKYVHSESCP-YYTRREFYVTNCkiDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYK
. .||.  |.  |  || |||..    |...... |.  . . .   .. | . |..   ... ||.||.|. ||  | .||.    ..||.... .. .
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWP..DhgvPssaksllelielvrelqe

nnknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKC---VDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
        .|| |||| |  |  . .|. .  . |. ||    .|.    ..|| ||. |. .  |||....|.... 
.....sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN6_pd Subfamily PTPN6 1172-1452 9.6e-53 174.1 In-house 12-298 (306) alignment 
Range on Protein: 1172-1452
Range on HMM: 12-298/306.0
AIESLKR-KPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTpLPMRENSTYINASFIEG--YDNSETFIIAQDPLENT
 .. |.. . . .|  .| |||.|  .. .   | . |.  ||. ||| . |.|.| .||||.  |   .|.||||..|..   ......| .|  ||.|
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett

IGDFWRMISEQSVTTLVMIS-EIGDGPRKCPRYWADDEVQ--YDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQFQYNGWPtvDGEVPEVCRGI
. |||||. ... . .||.  |.  |  || ||| | | .  | .| |. |...|  .|. ||. |..  | ... .| |.... ||  |  ||.    .
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWP..dhgvpkdpgav

IELVDQAYNHYKNNKNSgCRSPLTVHCSLGTDRSSIFVAMCILVQHLR---LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
......  ..... ...    |. |||| |  |   |. . ||.. ..   |.  .||  . ...|.|| ||..  .|| |...|| .| .
Ldfledvnrkqeeleea.eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1206-1448 4.1e-52 172.1 In-house 42-276 (315) alignment 
Range on Protein: 1206-1448
Range on HMM: 42-276/315.0
SVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADD
 |  . ||  |||  .||.||. || |  |   ..| |.||.||.||.  . .| || |. ....||||.. |. ....||.... .|  ||. .|| |.
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

EVQYDHILVKYVHSESCPYYTRREFYVTNckIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKnsgcrSPLTVHCSLGTDRSSIFVAM
.| | .| |  .  |    || | . |.    |.  .| |..|  ||  | .||. .  ...|. ..  | .|.      ... |||| |  |.  |...
kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswp..dmgvpkytiplmnlirtvkqhhtnsv.....gaivvhcsaGvGrtGtfitl

CILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
  .....  |. .|.    ...|..| ..... .||.|.. |..
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
0051429 (Phosphotyrosine protein) phosphatases II 943-1178 8.8e-52 171.7 In-house 2-245 (272) alignment 
Range on Protein: 943-1178
Range on HMM: 2-245/272.0
QTTDYINANFVIGYKE---RKKFICAQGPMESTIDDFWRMiWEQHLEIIVMLTNLEEYNKAKCAKYWP----------EKVFDTKQFGDILVKFAQERKT
....||||..| ||     ........||.. |..||||. .|...  ||.|...||... || .|||          . .. |  .|.. |.. .|  .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GDYIERTLNVSKNKANVGEeedrRQITQYHYLTWKDFMAPEHPhgIIKFIRQINSvyslqRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVS-----
 ||| |.| ...   .       |.....||. | |. .|...  ..........      ||.|||||||..||||.|||. |......|. |      
ldyilrellltlllsagea....revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---IYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTgTFGNTDICIDTMASAIESLKR
   ....|  || ||   ||.  ||.|||.|||.    . ...  .....|.. ...
nlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1213-1451 1.1e-51 170.5 In-house 28-268 (274) alignment 
Range on Protein: 1213-1451
Range on HMM: 28-268/274.0
NNMKNRSQEIIPYDRNRVILTPL-PMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADDEVQ--
.. ||| ..|.| .. ||.|..  .  |.|.|||| .| |||.  .... .| || ||. |||||| ...|. .||. .. .  . || .|. |.|    
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

---YDHILVKYVHSESCPYYTRREFYVTNCKIddTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAM
   |... .| ..  ..  |. |.... ...   . .|. . |  ||  | ..|.  . ...||..   . ......  ..|  |||| |  |  .|.|.
serygdveikvekiverndysvrklvlkyler..ersvkhywytdWP..dhksPddantlldlvlev..eesreeenaklapvvvhCsaGiGrtGcfiai

CILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
 | |..|| |. ||.  .. .|| .| |....  |||..|||.. | 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_CG7180_pd Subfamily CG7180 1184-1448 1.4e-51 169.9 In-house 12-287 (296) alignment 
Range on Protein: 1184-1448
Range on HMM: 12-287/296.0
KCKLEVEFEKLLATADEIS-KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVT
. | .||....| .. ...   |  | ..||  |||  ...||| |||.|. |   |.| ||||......   . .|. . | ..|...|||.. .. . 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TLVMISEIGDGPRKCPRYWADD-EVQYDHILVKYVHSESCPYYTRREFYVTNC---------K-IDDTLKVTQFQYNGWPTvDGEVPEVCRGIIELVDQA
..|.... .|  ...| ||  . . || .|.|..|.... .  . |.| .|           .   .|  |..||.  |.  . .|| .  ..|||. ..
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWel.edkvPlstnalielrrrv

YNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
    .....   ..|. |..| |. || ...|. . .. .. |..||.    ..|| .| .|...  .| ..   . 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1195-1453 4.4e-51 168.6 In-house 29-280 (287) alignment 
Range on Protein: 1195-1453
Range on HMM: 29-280/287.0
LATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDG
|   ..  ..  ..  ..|. |||...|...| .||.|      |.  ||||.||.|| ..  ||||. |. ||. .||..| .. ||..||...   . 
leqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekend

PRKCPRYWADDE-VQYDHILVKYVHSESCPYYTRREFYVTNCK-IDDTLKVTQFQYNGWPTvDGEVPEVCRGIIELVDqaynHYKNNKNSGcRSPLTVHC
 ..| .||.... | . .  .. .. |    |. |.. |.| .  .|...|.|.|.  |.   |.|.|    .. . .     ||... .| .... |||
eevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWds.tgkvtepqtillviee....myktqrkrg.ntsivvhC

SLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
| .  ||..|.|. . ... . |  .|.    .. | |. | .   .||.|.  ....| | 
sdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
0041856 (Phosphotyrosine protein) phosphatases II 917-1162 7.9e-51 167.5 In-house 1-176 (182) alignment 
Range on Protein: 917-1162
Range on HMM: 1-176/182.0
NACKNRYPDIKAYDQTRvklavinglqTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTnleeynkakCAKYWPEKVfdtkqf
|  ||||.||  ||..|            ||||||...|.   ..||..|||. ||. ||.||..|..  .||.||         .  ||||..      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdilvkfaqerktgdyiertlnvsknkanvgeeedRRQITQYHYLTWKDFMAPEhPHGIIKFIRQINSvyslQRGPILVHCSAGVGRTGTLVALDSLIQQ
                                    |...||.|| | |. .|. .. ...||.....    . ||.||||||||||||||||.. ....
...................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl

leeedSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNT
     .||....|. .| .|.  |... ||.||..|||.   ...|
.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_PTPN23_pd Subfamily PTPN23 1173-1451 4.5e-50 165.1 In-house 3-280 (288) alignment 
Range on Protein: 1173-1451
Range on HMM: 3-280/288.0
IESLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGY-DNSETFIIAQDPLENTIGD
.| |.||  .|| .|. .|..|  . |. ... |.   . .  ||||..|.|||.||| |      ..  ||||||...    . .||..| ||..|..|
veelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnD

FWRMISEQSVTTLVMISEIGD-GPRKCPRYWAD---DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdGeVPEVCRGIIEL
||.|. || . ..||. .  . |  |. |||     . |..... |   . .. ... .|.. ..  . | . .|.  |.. || . | ||.    ....
FWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpel.G.vPasPetllqf

VDQAYNHYKNNKNSgCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK-CVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
.|.. ..|.....  .. || |||| | .|. .|  .   |. |. ..  .||    ..|| ||   ..  .|..|.  |.... 
ldevesayeavqrk.sktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1188-1450 1.5e-49 163.7 In-house 26-283 (297) alignment 
Range on Protein: 1188-1450
Range on HMM: 26-283/297.0
EVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNseTFIIAQDPLENTIGDFWRMISEQSVTTLVMI
.|. |..| .     ..  | |.  |  |.| . |.|||..||.|  .    .| |.||||..|. .   .|  | | ..|. |||.|. .. |.|.||.
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

SEIGDGPRKCPRYWADDEV-QYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSgcrsP
..  .. .|| |||.|. | .. .. |.    ...  . .||. ||. |   .  | |.|.  ||. . |  .  . ...|...  .....|...    |
nddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg....P

LTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
| |||. |  | ......   | . . || |||  . .||| .|  |.    ||.|.. |....
llvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1205-1450 3.3e-49 162.4 In-house 36-276 (315) alignment 
Range on Protein: 1205-1450
Range on HMM: 36-276/315.0
CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWAD
  |. ...|  ||| ..|.|.|..||.|  .    .| |||||.|...|. ...| .| ||. .. |||||. .. |||.||...  .| . || .|| |
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd

---DEVQYDHILVKYVHSESCPYYTRREFyVTnCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHykNNKNsgcRSPLTVHCSLGTDRSSI
   | |..  | |. .  |..   . |.. ||  | ... .|||||...||  |  |..    ...|. .      |.|.     .| |||| |. |. .
rkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewP..dkGvdkqtssllklikevkad..ngkk...efsllvhcsaGvGrtGv

FVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
....   |.... .. ||.  . ..||..|  |...  .| |.. |. ..
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1207-1450 1.5e-48 160.2 In-house 37-275 (515) alignment 
Range on Protein: 1207-1450
Range on HMM: 37-275/515.0
VGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRK-CPRYWAD--
| ..| |  ||| ..|.|||..||.|  .    .| |.|||.|...||  ..| .| |.. .. ||||.. .. |||..|...  .| .  | .|| |  
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

-DEVQYDHILVKYVHSESCPYYTRREFYVTncKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNSGCrSPLTVHCSLGTDRSSIFV
 | |.. .| |. |  |.|   ..|.. |.  | ||.  ||||....||  |  ||. .. .. |. .     | ...     || .||| |  |  ...
gdsvkfGsikvelvsleactggikrkltvl..kgddsrtvtqfhfteWP..dkGvpkhtssllklikev....kadhgqyt.hpliihcsaGvGrtGvvi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
..   | | .  . ||.  . ...| .|  |.    || |.. |. ..
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_PTPN14_pd Subfamily PTPN14 1174-1450 2.9e-48 159.4 In-house 14-295 (300) alignment 
Range on Protein: 1174-1450
Range on HMM: 14-295/300.0
ESLKRKPNEGKckLEVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMReNSTYINASFIEGYDN--SETFIIAQDPLENTIGD
. |..| .|||  . .|.|..          .|.....||. ||| ....||. ||| |.|     .. ||||| |.      . ..|.|| |||.|. |
kilekkleegk..vfteyeripkkre..dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqd

FWRMISEQSVTTLVMISEI-GDGPRKCPRYWADD-----EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGII
||.|. || |. .||. |.  ||  |. .|. ..     .|....  |    ||. . .. . . .      .  .|  .||. ||  | .|||  .| .
fWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp..dhgvPeDvkgfl

ELVDQAYNH-YKNNKN---SGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
. ...     .| |..      . |. |||| |  |. . .   .|.. |  .. .||  . ..|| ||  |... |||.|.....|.|
syLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_PTPRN_pd Subfamily PTPRN 1183-1449 3.9e-48 158.7 In-house 27-290 (297) alignment 
Range on Protein: 1183-1449
Range on HMM: 27-290/297.0
GKCKLEVEFEKLLATADEiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSV
 | .|| |.| | |   |  ....|...|.|  ||||....||| .|| |.    .|.| |||||.|   |    ..| .| || .|. |||.|. || |
nkdrlekewealcayeae.pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

TTLVMISEIGD-GPRKCPRYWADDEVQYDHILVKYVHSES--CPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKnn
. .|..... . | ..| ||| |.  .  ||    . ||   |  |  | ||. | . ..|  |||| .  ||    .||   . ..|.  .    |.  
vvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee..gvPasaksllefrrkvnksyr..

knsGCRSPLTVHCSLGTDRSSIFVAMCILVQHL-RLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
   |  .|. |||| |. |. ..... .....| .  | .||.||  .|| ||.||... .|.||   |...
...GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 916-1155 5.5e-48 158.2 In-house 6-238 (239) alignment 
Range on Protein: 916-1155
Range on HMM: 6-238/239.0
ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfdTK
 | .|||| .| .||..|| |  ..    .|||||...  |    | .|..|| .| .  |||||.|...  .||||| | |  | || .|||.    | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGDILVKFAQERKTGDYIERTLNVSKnkanVGEEEDrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLI
.. .. | . .     ||| ||. .|.    ||. |. | . |||.  | |   |..   .. . |.|         | ..||||||||||... .|...
kycnlrvtlrktevfadyiirtfvmsq....vgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

QQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
.| ... .| |.| |  .| .| ..||. .||.|.. |.|.
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1194-1450 7.7e-48 158.3 In-house 31-287 (325) alignment 
Range on Protein: 1194-1450
Range on HMM: 31-287/325.0
LLATADEISKScsVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG
|| . | |.|   |    ||  ||| ......|..||.|  .    .| |||||... . . ..|. || || .||.|.||.. .   . .|.. |.  |
llpsddgiakk..vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlg

PRKCPRYWADD---EVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWP-TVDGEVPEVCRGIIELVDQAYNHYKNNknSGCRSPLTV
  .|  || ..    ...  . || .  |    |  | . | . |  .|. | |||. .|.     . |     |..||..  .  . |  . . .|. |
kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan..tkastpilv

HCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
||| |  |. .|...  .....  |  |||    .||| .|  ....  || ... |....
hcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
0049772 (Phosphotyrosine protein) phosphatases II 902-1155 7.9e-48 159.1 In-house 31-278 (314) alignment 
Range on Protein: 902-1155
Range on HMM: 31-278/314.0
NRFSDRTTKNSDLKENACKNRYPDIKAYDqTRVKLAVINGlQTTDYINANFVIGYkerKKFICAQGPMESTIDDF----------WRMI--WEQHLEIIV
.  .. |.. .|| .|  ||||.||  .| .||.|   .. ...|||||..| |.   .|||..|||.| |..||          |||.  ..... .||
svlpeltilvadlflnrdknryldilpad.nrvilpglpv.sgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LTNLEEYNkakcaKYWPEKVFDTKQfgdilvkfaqerktgdyiertlnvsknkaNVG--EEEDRRQITQYHYLTWKDF
|                     |..| ...      ..... ... .                             ..    |   |.. .|... . |.
msrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.............................eelydpelferlgikylripvpDg

MAPeHPHGIIKFIRQINSVysLQRGPILVHCSAGVGRTGTLVALDSLIQQLeeedSVSIYNTVCDLRHQRN-----FLVQSLKQYIFLYRALLD
 ||  .  . .|.. |...   . ||.||||.||.|||||.|... |. .|     ||.  .. |.| .|       ....|.||.| ..|||.
sap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 916-1154 7.9e-48 157.7 In-house 7-238 (239) alignment 
Range on Protein: 916-1154
Range on HMM: 7-238/239.0
ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKE-RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKvfdTK
 | .|||| .| .||..|| |  ..    .|||||...  |    | .|..|| .| .  |||||.|...  .||||| | |  | || .|||.    | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGDILVKFAQERKTGDYIERTLNVSKnkanVGEEEDrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLI
.. .. | . .     ||| ||. .|.    ||. |. | . |||.  | |   |..   .. . |.|         | ..||||||||||... .|...
kycnlrvtlrktevfadyiirtfvmsq....vgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

QQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
.| ... .| |.| |  .| .| ..||. .||.|.. |.|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 898-1155 9.3e-48 157.8 In-house 23-275 (307) alignment 
Range on Protein: 898-1155
Range on HMM: 23-275/307.0
EMLPNRFSDRTTKnSDLKENACKNRYPDIKAYDQTRVKLAvINGLqTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEY
..| ..  .  |    .. |. |||| |.|. |..|. .  ..|| ..||| ||..    . |||||||||.|.|. .|| |. ....| ..|| .. | 
rvlakktpegvtv.eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviel

NKAKCAKYWPEKVFDTKQFGDILVKFAQE---RKTGDYIERTLNVSKNKANVGEeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvyslQRGPIL
 | || .||| .  ... ||.     . .    |.    |  .||.. | . ..  . | |... .  | |  .|.   . | ..  ..     .. |..
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaq..ksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvv

VHCSAGVGRTGTLVALDSLIQQ-LEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
|||||||||.||.||.  . .. .. ..  .. . | .|| ||.. .|.  ||..|.| ||.
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_PTPN3_pd Subfamily PTPN3 1188-1451 1.7e-47 156.7 In-house 18-275 (280) alignment 
Range on Protein: 1188-1451
Range on HMM: 18-275/280.0
EVEFEKLLATADEIskSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIE----GYDNSETFIIAQDPLENTIGDFWRMISEQSVTT
 ..||.|     ..  ..|.    ||  ||| ..|.|||  ||.|.     ... ||||....    . . .  .|..| ||..|  |||.|. ||....
laqfeqlyrkkpgl..aisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

LVMISEI-GDGPRKCPRYWA--DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnkn
.||. ..  .|  || .||   .||..| .. ||  ....   |  ||..... . ..  |..|.||  ||  | .||.    ..|.|..  .       
ivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWp..dhgvPddsadflefvervrklr.....

SGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
|| ..|. |||| | .|. ..... . .. .  .. | . .  |..| ||. |... .||.|.  ||.. .
sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1203-1449 6.6e-47 154.7 In-house 23-264 (283) alignment 
Range on Protein: 1203-1449
Range on HMM: 23-264/283.0
KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMrensTYINASFIE---GYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCP
... .  ..||. ||| |||.|.|..|| | ...     .||||.||     |.... .|||| ||..|. |||.|. .. .|..||.... .. | || 
ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

RYWADD-EVQYDHILVKYVHSESCPYYTRREFYVTNC-KIDDTLKVTQFQYNGWptvdG---EVPEvcrgIIELVdqAYNHYKNNKNSGCRSPLTVHCSL
.||  .  ..|    |   .  .   ....|. . .     .|| .. .|...|        | .     |  ||   .|  . ...   ..|. |||| 
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqai....inslv..kfnkvislqteskkgPivvhCst

GTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
|  |...|.|.   |.... |  ||. |. . .| || ... .  || ..| ....
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 913-1158 1.1e-46 153.8 In-house 52-284 (290) alignment 
Range on Protein: 913-1158
Range on HMM: 52-284/290.0
DLKENACKNRYPDIKAYDQTRVKLAviNGlQTTDYINANFVIGYKerKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFD
|   .  |||| |.   |.||| |   .| .  ||. ||.| | |    || .||....|. |.|||. ...   |||| .| |  ||||..|.|||  .
dkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

TKQFGDILVKFAQERKT-GDYIERTLNVSKNKaNvGEEedrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVyslqRGPILVHCSAGVGRTGTLVALD
.  ||.| |  ..| .   . | .|| | . . . | |    ..  ..  .| |   .     ... .| .  .     ||. ||||||.|||||.||..
vltfGeitvlcseeddkdaniikktlsvrdkd.s.Gke...hklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaie

SLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGT
  .| | .  .. . ..|  ||. |   ||   ||. | ..||| | 
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1186-1451 9.1e-46 150.9 In-house 11-277 (287) alignment 
Range on Protein: 1186-1451
Range on HMM: 11-277/287.0
KLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV
... |...|   ..  .      |.  .  |||  ...|.| .||.|.  . .  | |||| .. .| . |.|| || |.  |..||||.. |. .....
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MI-SEIGDGPRKCPRYWADDEVQY---DHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKNS
..  |. ..  || .|| . ||      . .|   ..   | |. | . . . .  ..  | |...  ||  |. ..  . |.| .| .  .| . ....
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswP..dkvlaPtavglirfvldvkqhielarda

GCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
    || ||.. |  || |..|. .||. |     ||. |.  .|| .|..|...  |. .|  |.. | 
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
0036282 (Phosphotyrosine protein) phosphatases II 945-1150 1.1e-45 150.7 In-house 2-163 (174) alignment 
Range on Protein: 945-1150
Range on HMM: 2-163/174.0
TDYINANFVIGYKERKKFICAQGPMEstiddFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvfdtkqfgdilvkfaqerktgdyiertlnvsknka
.|||||... ..   ...|. |||..     ||.|..|......|||....| .. ||  ||||                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

nvGEEEDRRQITQYHYLTWKDFMAPEHPHgIIKFIRQINSVYSL-QRGPILVHCSAGVGRTGTLVALDSLIQQLEeEDSVSIYNTVCDLRHQRNFLVQSL
    |  .| . ||.|| | |. .|. .  ...|........|  . ||.||||||||||||||||.. ....|. |. | ....|  || ||   ||. 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

KQYIFLY
 ||.|||
sQyrfly
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 895-1155 2.8e-45 149.6 In-house 23-269 (288) alignment 
Range on Protein: 895-1155
Range on HMM: 23-269/288.0
REYEMLPNRFSDRTTKNsdLKENACKNRYPDIKAYDQTRVKLAvingLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNL
.||.  ||  | .. ..    .|....|| ..   | |||||       .  ||.|| |   | ....|||| |...||. .|.|. |. .| ||||..|
keyrdspneasidiids..fianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcel

EEYNKAKCAKYWPEKVFDTKQFGDIlVKFAQERKtgDYIERTLNVSKNKANVGEeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQInsvYSLQRgPIL
 |  | | |.|.| |. .. ..| .  .  ....  . |.....||  . .    |..  . . |.| |.|   ||     ....  .    |||. ||.
lekGkeksaeyfPsklGekarigrl.ctvvkkkr..adidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevl...kslqk.Piv

VHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
||.||||||||||.     ...|  .| ..| . .  || .|   .|. .||....| .|.
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1205-1452 4.8e-45 148.6 In-house 12-265 (270) alignment 
Range on Protein: 1205-1452
Range on HMM: 12-265/270.0
CSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA
 .. |   ..  ||...|.|  . ||.| .|   ....|||| ...|.|.. ...| |. ||..|. .||||| |. ||..||.... . | .|| |||.
sdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKID---DTLKVTQFQYNGWP--TVDGE--VPEVCRGIIELVDQAYNHYKNNKNSGcrsPLTVHCSLGT
 .  .  ..    ..  ..    .. . .|. ..    .. ... |.|| ||  .|  |       . ..... .  .. |. ....   || |||| | 
aepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae...PllvHcsaGv

DRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
.|. ...|. | |. |  .| ||. |  ..|| .|. |..   |||||..|...| .
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 902-1155 9.5e-45 147.6 In-house 32-285 (305) alignment 
Range on Protein: 902-1155
Range on HMM: 32-285/305.0
NRFSDRTtKNSDLK--ENACKNRYPDIKAYDQTRVKLaviNGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNK
.|| |   |   .|  ..| |||| |.   |. ||||   .|    .|| ||.|    . |.|||.| |.| |  ||| | .....| | || || |   
krfndfe.kmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekga

AKCAKYWPEKVFDTKQFG----DILVKFAQERKTGDYIERTLNVSKNKANV-GEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvyslQRGPIL
 ||..|.. |  |. .|      | |||    .     .   .|.. .  . |  |. |..|.||.  | |   |     |.... .  .     .||| 
kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp....skgpiv

VHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNT-VCDLRHQRNFLVQSLKQYIFLYRALLD
||||||.||||..| |. ...|| . . .   .  .  .| |||  .|. .||.|... .|.
vhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 888-1155 1.2e-43 144.1 In-house 3-257 (267) alignment 
Range on Protein: 888-1155
Range on HMM: 3-257/267.0
DTDYGFLREYEMLpNRFSDRTTK--NSDLKENACKNRYPDIKAYDQTRVKLAVinglQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHL
| .  . .|.|.. .. || ...   |  ..|. .||. |   ||.||| |      .. .|||| .| ||| ...||  |.|.. || ||. .| .|..
deeceiekefeli.kkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkv

EIIVMLTNLEEYNkakCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVsKNKanvgeEEDRRQITQYHYLTWKdFMAPEHPHgiIKFIRQINSV
 .||.||.  . |     ..|| |. ..|.. |. |... |..  ||   ||.. | |     .|  ...| |.|  |.   . ..|.  .| .  | . 
pvivlltkvftdn...irlfwPPkmgqakkyqdltvehslekeendyqiitlel.kfk.....nesahnvtlyyykkwn.intnnkpy..lkplfgilak

YSLQRG--PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
  |. |  |..|.||.||||.||.. .|| .... .|. . |.. .  .|.||  ||... .||.... | .
nqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1196-1455 1.3e-43 143.8 In-house 23-297 (301) alignment 
Range on Protein: 1196-1455
Range on HMM: 23-297/301.0
ATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPM--RENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG
.  .. .|||.|| .|||.. || ..| .|| ||.||.| |     . .|||||.|.|| ... ||.||.|...|. ||||.| .. ....||. .  .|
elkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkeg

-PRKCPRYWADDEV---QYDHILVKYVHSESCPYYTRREFYVT-----------------NCKidDTLKVTQFQYNGWPTvDGEVPEVcRGIIELVDQAY
   || .|| . |    .. .. |. |..   | .. |.. |.                 . |  .. .|.|.|   ||. || |.|  | ... .|.  
tkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpq.dGvvrep.rtvLqviddvi

nhYKNNKNSGcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLHH
  ....| .|  .|. |||| .  || ..... | .   . |  ||.   |. .| .. | .    || ... .|  |  |..
..hrqqkigg..gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
0046846 (Phosphotyrosine protein) phosphatases II 945-1153 1.5e-42 140.6 In-house 12-169 (176) alignment 
Range on Protein: 945-1153
Range on HMM: 12-169/176.0
TDYINANFVIGYkerkKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEkvfdTKQ--Fgdilvkfaqerktgdyiertlnvskn
 ||||||...|.    ..|. |||...|. ||..|..|.. ...|.||.. |... ||. ||||     ..  .                          
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..........................

kanvgeeedrrqitQYHYLTWKDFMAPEHpHGIIKFIRQINSVYSLQrGPILVHCSAGVGRTGTLVALDsliqQLEEEDSVSIYNTVCDLRHQRN-FLVQ
              ||..| | |. .|..   .......|.....   ||.|||||||.||||||||..     || |  .|...... .| ||  . ||
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

SLKQYIFLYRAL
. .|| |||...
tpeQyrflyefe
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 892-1158 1.6e-42 140.1 In-house 12-270 (281) alignment 
Range on Protein: 892-1158
Range on HMM: 12-270/281.0
GFLREYEMLPNR-FSDRTTKNsDLKENACKNRYPDIKAYDQTRVKLAV-INGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIV
 | .|.  ||    ||  |   .   |  |||| .| . | .||.| | .   ..|||| ||..     .. .| .||| . |  |||||||..    ||
dfkqefsnlpgdppsdlctvf.nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERktgdyIERTLNVskNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvyslQ
|| .. | |. |||.|.| .     ||  . |.. .       ....|     . |.  | . | ||.. .  | |.  ||    ..| .|.| .    .
mlcqfletnrekcaeyfprnahcclqfdklsvsyedst.....vnkslvt..trlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....r

RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSV-SIYNTVCDLRH-QRNFLVQSLKQYIFLYRALLDTGT
  | ..||||||||.|||.|..  .| .    ..  | . |  ||   |   ||.|.||..... ||| | 
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1188-1449 4.3e-42 139.1 In-house 23-277 (439) alignment 
Range on Protein: 1188-1449
Range on HMM: 23-277/439.0
EVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMI
. .|||. .|  . .  .|.  .| .. ||| ... ..|  ||.|  .|    | |||| .|.|| . . .| .| | ..|  ||||.. |. ..|.||.
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

SEIGDGPRkcprYW-ADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKiDDT---LKVTQFQYNGWPtvDGEVPEVCRGIIELVdQAYNHYKNNKNSGc
... .  .    || .|.|| |  | |.  .    | |. | | | | . | |     | ||.|  ||  | .||  .  ..... .| |  ..... | 
tnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfner.dttekertvlqfhyiawp..dknvpaqashvldfl.rainsandkeeyg.

rsPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
  |. |||| |  |.   .|. | ...|.||. |||    . || ||. .... .|| |.. |...
..pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_ptpA1_pd Subfamily ptpA1 894-1117 1.3e-41 137.7 In-house 24-256 (418) alignment 
Range on Protein: 894-1117
Range on HMM: 24-256/418.0
LREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKeRKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
  |. .| .      | . | | |. |||| .|   ..|||.|  |.  . .||||||.. |    |.|||.|||.  || |||||.||..  |||||. 
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsr

LEEYNKAKCAKYWPEKVFdTKQFG------DILVKFAQERK-TGDYIERTLnvSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQI----
  |  . || .||||..   .||       ...  .. |     .  || .     .  .  | . |.||||.|  | |.  |.| . . .... |    
esencrikcdrywpeqig.geqfsiygngnevfgtysvelveviqdperei..itrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

-NSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQL
 . . | .|  ||.||||||||||||...   ....|
nqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_PTPN13_pd Subfamily PTPN13 1202-1449 1.5e-41 137.5 In-house 26-267 (273) alignment 
Range on Protein: 1202-1449
Range on HMM: 26-267/273.0
SKSCSVGENEENNMKNRSQEIIPYDRNRVILTplpmrENSTYINASFIEGYDN--SETFIIAQDPLENTIGDFWRMISEQSVTTLVMI-SEIGDGPRKCP
 ..|.||...||. ||| ....|||. ||.|      ....|||||.|.   .    ..|..| || .|. |||.|. ||... ..|. .|  .|  || 
ldtcevgkkkenkdknryrnvlPydetrvklg.....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

RYWADDEVQ----YDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAyNHYKNnknsgCRSPLTVHCSLG
||| . . .    .. . |. .. .    .. |.. |.. .  .. .|.....  ||  | .||     ....| .  .. ..      ..|. |||| |
rywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwP..dhgvPssaaellqfvaev.rrlqt.....dagPivvhcsaG

TDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
  || ..... .... .  .| .|.  . |||| || |.. .  || | ..||..
iGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 914-1155 1.8e-41 136.7 In-house 52-287 (305) alignment 
Range on Protein: 914-1155
Range on HMM: 52-287/305.0
LKENACKNRYPDIKAYDQTRVKLAVINglqTTDYINANFVIG-YKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFD
 . .  |||| |. . ||. |||.  .    .||| ||.|       |.|||||||.. |||.|| |. ....| |||| .  |  | |||.|||    .
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

TKQFGD-ILVKFAQERKtgdYIERTLNVSKNKANVGEEEDRRqiTQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALD
 ...   |.|.     |    .||  ..     |.    |..      .| | ..     |   .  .  . ..    . ||.||||||.|||||.||..
klelksgivvenvsgsk...pmerdaeiqitllnltysgdqk..msvrhlqwtewpdrgvppckltslellsairg.skvpivvhcsagigrtgtivaie

SLIQQLEEEDS-VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
 ..... |. .   . . |  || || | .|.  ||.|..| .|.
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0043147 (Phosphotyrosine protein) phosphatases II 944-1150 3.8e-41 136.0 In-house 4-154 (172) alignment 
Range on Protein: 944-1150
Range on HMM: 4-154/172.0
TTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLeeynkakcakywpekvfdtkqfgdilvkfaqerktgdyiertlnvsknk
 .|||||... .|   ..||. |||. .|..|||||..|..  .||.||.|                                                 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

aNVGEEEDRRQITQYHYLTWKDFMAPeHPHGIIKFIRQINS-VYSLQRGPILVHCSAGVGRTGTLVALDSLIqqleeeDSVSIYNTVCDLRHQRNFLVQS
  .  |   |.. ||.|| | |. .| ..  ...|...|.. .   . ||.||||||||||||||||.. ..       ..|....|. .|..|.  ||.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

LKQYIFLY
  ||.|||
psqyrfly
0049260 (Phosphotyrosine protein) phosphatases II 954-1150 4e-40 132.3 In-house 3-143 (152) alignment 
Range on Protein: 954-1150
Range on HMM: 3-143/152.0
IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWpekvfdtkqfgdilvkfaqerktgdyiertlnvsknkanvgeeedrr
 ||.  ..||..|||.. |..|||||..|..  .|||||.|.| .| ||..|.                                               
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................

qitQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIqqleeeDSVSIYNTVCDLRHQRNFLVQSLKQYIFLY
   ||..| | |. .|...  .. ... |.  .  . ||.||||||||||||||||.. ..        ||....|  .| .|.  |..  |..|||
...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPN1_pd Subfamily PTPN1 1193-1451 1e-39 131.0 In-house 10-271 (290) alignment 
Range on Protein: 1193-1451
Range on HMM: 10-271/290.0
KLLATADEISK--SCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEI
... . .. ..  .... ...||. .|| ... |||  |..|     |..  |||||..|  .    .|..| || ||.. ||.|. ||   ..||. ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

-GDGPRKCPRYWA----DDEVQYD--HILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKNSGc
   .  || .||     ..|....  .. ||... |.  |||.| . ..| | ..| ....| |  ||  |  |||     .... .  .    ... | 
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwp..dfgvpespaaflkflfkvresGslssdvG.

rsPLTVHCSLGTDRSSIFVA-MCILVQHLRLEK--CVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
  |  .||| |  ||  |.   ..||.  . ..  .|||  .  .||..|.|||    | .| . ||.. .
..pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1182-1452 1.6e-38 127.2 In-house 3-260 (267) alignment 
Range on Protein: 1182-1452
Range on HMM: 3-260/267.0
EGKCKLEVEFEKLLATADEISK-SCSVGenEENNMKNRSQEIIPYDRNRVILTplpMRENStYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQS
. .|..| |||..   .|. |. |.|..  |.|. .|| .. .||| .||||     .|.  |||||..|||   ..||. ||||.|||.||. .| .| 
deeceiekefelikkisdtsstisqsia..eknqernrlddnlpyddtrvilr...tkeee.yinasyvegyktknafivtqdplkntitdfltvihdqk

VTTLVMISEIGDGprKCPRYWADD---EVQYDHILVKYVHSESCPYYTRREFyVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVcRGIIELVdqAynhyKN
|.. |..  .. .  . ...|        .|. . |..   .    |    .   . | . . .|| . |. |     . | . . .. ..  |    ||
vpvivlltkvftd..nirlfwPPkmgqakkyqdltvehslekeendyqiitl.elkfknesahnvtlyyykkwnintnnkpyl.kplfgil..a....kn

NKNSGcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
. . |   || |.|| |  ||  |. .   .. .. |  .||    ||.|||| ||...  .| ..|. . .|..
qleng.nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
0044763 (Phosphotyrosine protein) phosphatases II 929-1152 3e-38 126.6 In-house 2-166 (178) alignment 
Range on Protein: 929-1152
Range on HMM: 2-166/178.0
YDQTRVKLAVINGLQTTDYINANFVIGYkerkKFICAQGPmestiDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFdtkqfgdilvkfaqerk
.| |||.|  . ||...|||||......     ......|      |......|...  ||.||.  |... || .||||.                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tgdyiertlnvsknkanvgeeedrrqiTQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQleeedSVSIYNT
                            ||... . |. .|. .  . .|.. |..... . ||.||||||||||.|||||.. ....     ..|... 
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleea

VCDLRHQRNfLVQSLKQYIFLYRA
.  .| .|.  |..  |. .||. 
ielvrerRp.ivpnpgqlrqLyef
0051429 (Phosphotyrosine protein) phosphatases II 1240-1451 2.2e-37 124.5 In-house 3-225 (272) alignment 
Range on Protein: 1240-1451
Range on HMM: 3-225/272.0
NSTYINASFIEGYDN---SETFIIAQDPLENTIGDFWRMiSEQSVTTLVMISEIGDGP-RKCPRYWA-------------DDEVQYDHILVKYVHSESCP
 |.||||... || .     ... .. ||..|. ||||.  |. ..| |.. .    .  ||.|||.             . .. | .. |.... | ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

YYTRREFYVTNC-KIDDTLKVTQFQYNGWPTVDGEVpEVCRGIIELVDQaynhyknnknsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVD---
.|. ||...|.. . .....|....| .||.      | .. ..||. .               |. |||| | ||. ..||. .|.. . ||  ||   
dyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld.............ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----ICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
     . .. ..||.|| | . ...||.||..|.... 
ltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 912-1085 4.6e-37 122.5 In-house 26-196 (297) alignment 
Range on Protein: 912-1085
Range on HMM: 26-196/297.0
SDLKENAC--KNRYPDIKAYDQTRVKLAviNGLQTTDYINANFVIGYKERK--KFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP
|  | |..  |||| || |.|.|||||   ..   .|||||..|.  .| .  |.|.||||...|.||||....|| . .|||...|.|  . ||| |||
ssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

EKVFDTKQFGDILVKFAQERkTGDYiERtLNVskNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV
. | . .. ||..|.|  .  . .. .| . .   . ..   ...|...   .|.| |   |   . . .|  |. |.
svvqerlkagdvvveflsst.sdef.dr.vil..telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 892-1164 1.1e-36 121.0 In-house 28-296 (310) alignment 
Range on Protein: 892-1164
Range on HMM: 28-296/310.0
GFLREYEMLPNRFsDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAvINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVML
|. ..|  |  .  | .      |..  |||| |.   |..||||  |.  .  ||| ||.|     |. |||.|||.. || ||||||...  | |..|
glvkqyrkldakq.dssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TNLEEYNKAKCAKYWPEkVFDTKQFGDILVKFAQERKtGDYIERTLNVSKNKANVGEEEDRRQITQ--YHYLTWKDFMAPEHPHGIIKFIRQiNSVYSLQ
 .  |  . ||  |||  .  |. .| | |    |    ..    | |.    ||  .|.  .. .     . | ..     |    . . |   .  ..
ckvgeegrpkcvgywps.lgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rllaqvr

RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTgTFGNTDI
 || .||||||..|....|||.  |..|.. . | . . . .|...|   .|.  ||... |  .   . |.|..
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif.argetev
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 916-1154 1.6e-36 120.8 In-house 46-341 (350) alignment 
Range on Protein: 916-1154
Range on HMM: 46-341/350.0
ENACKNRYPDIKAYDQTRVKLA--------VINGLQTTDYINANFVIG----YKERKKF--ICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAK
|   |||| .|  |...||||         .   |.| ||||||..       .   .|  | .|.|. ||.|||...| . . ..|..||.. |.|  |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAKYWPEKVFDTKQFgDILVKFAQERKTGD----------------YIERTLNVSKNKANVG---EEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIR--
| .||.|  .| ..   .  |  .   . |                 |.   .. .|. ..       |   . | ..  |||     .|. |.. .   
cyrYWqegsydditv.klaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevk

-----Q-INSVYS--LQRGPILVHCSAGVGRTGTLVALDSLIQ---QLE--EEDS----------VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
     . .   ..   .  |||||||||||||||||.||||..    ||  ...|            |  .|  ||.||  .||.|.|.||.| |||
ndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_egg_pd Subfamily egg 893-1154 2.9e-36 119.7 In-house 16-267 (307) alignment 
Range on Protein: 893-1154
Range on HMM: 16-267/307.0
FLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLT
. | .|.| .   . . ...  ..|  | | . ..  | .|||| . .|  . |.| || | |     .||.|| |.  | ||||||..... . |||||
lerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlt

NLEEYnkAKCAKYWPEKVFDTKQF--GDILVKFAQERKTGDYIertLNVSKNKAnVGEEEDRRQITQYHYlTWKDFMAPEHPHGIIKFIRQINSvyslqr
   |    .|  |||    |. ..  | . ..  .  .. | .   ..|.| |  || ... | .  . .  ..       |  ... .|..        
srkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklkl.vGgddeerflehwqg.dvnnssdvysplrvlrklrnlsk......

gPILVHCSAGVGRTGTLVALDSLIQQLEEE--DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
 |..|..  || ...||||..  . .|         . ..|  || .|.. |.|  .|.|.|| .|
.pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0051082 (Phosphotyrosine protein) phosphatases II 945-1153 4.4e-36 119.1 In-house 3-149 (151) alignment 
Range on Protein: 945-1153
Range on HMM: 3-149/151.0
TDYINANFVIGYkerkkFICAQGPMEstidDFWRMIWEQHLEIIVMLTNLEEYNkaKCAKYWPEKVfdtkqfgdilvkfaqerktgdyiertlnvsknka
.||||...| |.     ... .||..    ||.....|...  ||.|...||..  .|..|.||                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

nvgeeedrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSvysLQRGPILVHCSAGVGRTGTLVALDSLIQQleeedsVSIYNTVCDLRHQRNFLVQSLK
        ........| |.|.  |.... ...|......    . ||.|||||||.|||||||||. ....      ||.. .. ..| .|  .||.  
........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

QYIFLYRAL
|..|...||
qflfqlfal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1204-1449 6.8e-36 118.5 In-house 36-234 (392) alignment 
Range on Protein: 1204-1449
Range on HMM: 36-234/392.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPrkcprywad
  .|...| |  ||| ..|.|||..||.|  .    .| |.|||.|...|| ...| .| |   .. |||||. .. |||..|.... .|          
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

devqydhilvkyvhsescpyytrrefyvtncKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYknnknsGCR-SPLTVHCSLGTDRSSIFV
                               | ||.  |.||..  ||  | .||.    ..... .   ..      |    || .||| |  |. . .
...............................kgddartvaqfhftewP..dkdvpkhtssllkfikevkadf......Gqythpliihcsagvgrtgvvi

AMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
..  .| | .  . ||.     ..| .|  ....  || |.. |...
sidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 915-1155 2e-35 117.1 In-house 33-268 (285) alignment 
Range on Protein: 915-1155
Range on HMM: 33-268/285.0
KENACKNRYPDIKAYDQTRVKLAVinglQTTDYINANFV-IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDT
. |   ||| |... ..||| |      .  ||| |... .  |..  .| .|||.  |. |||.||.....  ..||  | |    ||| |.|||. . 
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

KQFGDILVKFA--QERKTGDYIERTLNVSKNKANVGEeEdrRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALD
 .||   . ..  .|      |  .| | . .    |      . . .   | | .|||  . .|.. . .. |   .  || |||||||||| |.| .|
vkfgkyeitlteckeeaiagtilnaltvintedasse.p..lymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgid

SLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
    .. |.  . . . | ..|  |   |||  |..|||  |..
yatirimenpniemldivremramrfqavqshmqflflyvvlme
PTPc_DSPc_SM00012 1055-1154 2.3e-35 116.3 In-house 2-104 (105) alignment 
Range on Protein: 1055-1154
Range on HMM: 2-104/105.0
ITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR--GPILVHCSAGVGRTGTLVALDSLIQQLEEE-DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
...|||..|.|. .||... |....|....... .   .|..||||||||||||.|||| |.||||.| ..|.|...|. ||.||. .||.. ||.||||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALL
|||
all
0049772 (Phosphotyrosine protein) phosphatases II 1202-1452 1.4e-34 115.6 In-house 35-281 (314) alignment 
Range on Protein: 1202-1452
Range on HMM: 35-281/314.0
SKSCSVGENEENNMKNRSQEIIPYDrNRVILTPLPMREnSTYINASFIEGYdnsETFIIAQDPLENTIGDF----------WRMI--SEQSVTTLVM---
.... |.  ..|  |||...|.|.| |||||  ||..  | |||||.. |.    .||..| |||.|. ||          |||.  ... | ..||   
eltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ISEIGDGPrkcprywaddevqydhilvK----------YvhsescpyytrrefyvtnCKIDDTL--KVTQFQYNGWPTVDGE
                  . ..  ..                                                   ..|    . . ..|  .|. ||.
evladelsrLdaAlgKtpllildgng...................neptaadlellk..................eelydpelferlgikylripvpDgs

VPevcrgIIELVDQAYNHYKNNknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLrlekCVDICATTRKLRSQRT-----GLINSYAQYEFLHRAIINYS
.|     ..| .|..... ...      .|. |||. | .|.  ||....|. .|     |..  . . .|..|.     |.|... |||| ..|. .| 
ap.....lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleyl

D
.
k
0041856 (Phosphotyrosine protein) phosphatases II 1213-1450 5.7e-34 112.7 In-house 1-170 (182) alignment 
Range on Protein: 1213-1450
Range on HMM: 1-170/182.0
NNMKNRSQEIIPYDRNRviltplpmreNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISeigdgprkCPRYWADDEvqydhil
|  ||| ..|.|||..|          ...||||... |.  . .||..| || .|. ||.||. |. .||.|...        ...||....       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

vkyvhsescpyytrrefyvtnckiddtlKVTQFQYNGWPTVDGEVPEvCRGIIELVDQAYNhyknnknsgCRSPLTVHCSLGTDRSSIFVAMCILVQHlr
                            . . .||  .|  |..||.  . ..........            |  |||| | .|.  .||. .. ..  
............................erlgiqylylpwpDhgvpd.ldelldfieevle.........eggpvlVHCsaGvgRtgtlvaaylmkkl..

lekCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
    |..  . . .||.| | . .  || ||..|.  .
...gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1212-1448 5.3e-33 109.2 In-house 2-236 (237) alignment 
Range on Protein: 1212-1448
Range on HMM: 2-236/237.0
ENNMKNRSQEIIPYDRNRVILTPlpMRENSTYINASFIEGYDNS-ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWAD--DEVQ
||..|||  .|. || .||.|       .| ||||....|.| .  ..| || |||..  |||.|. ..  . .||.. . .|   || .|| .  .   
enkiknrygnivaydhsrvvlkg..agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YDHILVKYVHSESCPYYTRREFYVTNCKIDDTLK-VTQFQYNGWPtvDGEVPEVCRGIIELVDQAYNHYKNNKNSGcrsPLTVHCSLGTDRSSIFVAMCI
|  . |   . |    || | . ...      .. . |.|.  ||  |  ||. .  .. .  .  |. .   .||   |  .||| |  |. ||. .  
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswp..drgvpqqtaallrfrkniinrsphvsesg...pwiihcsagvgrtgiflvida

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
.... . .| |||      .  .|  .|..  || |.|..|.
mlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1213-1448 2.8e-32 106.8 In-house 7-237 (239) alignment 
Range on Protein: 1213-1448
Range on HMM: 7-237/239.0
NNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSE-TFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADDEVQYDH
|. |||  .|. ||..||.|  |     | |||||..  || |  ..| .|  .| . ||||||. ..    .||.. . .|  .|| .|| |   .|  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

ILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNSGCRsPLTVHCSLGTDRSSIFVAMCILVQH
. |   ..|    |  | | ...    .   | |...  ||  |  ||. .  .. |  .      ..   |.| |  .||| |  |.  |. .  ....
lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp..dkgvpqyatavlglrrki....tkdslpgar.pwvihcsagvgrtgaflvidamlrq

LRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
 . .| |||    . .| .|  ....  || |.| |..
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1212-1448 3.1e-32 106.7 In-house 7-238 (239) alignment 
Range on Protein: 1212-1448
Range on HMM: 7-238/239.0
ENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSE-TFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADDEVQYD
 |. |||  .|. ||..||.|  |     | |||||..  || |  ..| .|  .| . ||||||. ..    .||.. . .|  .|| .|| |   .| 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

HILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNSGCRsPLTVHCSLGTDRSSIFVAMCILVQ
 . |   ..|    |  | | ...    .   | |...  ||  |  ||. .  .. |  .      ..   |.| |  .||| |  |.  |. .  ...
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp..dkgvpqyatavlglrrki....tkdslpgar.pwvihcsagvgrtgaflvidamlr

HLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
. . .| |||    . .| .|  ....  || |.| |..
qakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 919-1147 6.3e-32 105.5 In-house 52-271 (301) alignment 
Range on Protein: 919-1147
Range on HMM: 52-271/301.0
CKNRYPDIKAYDQTRVKLaVINGLQTTdyINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGD
 |.||| .    .| |.. . .| .    | ||..    . ..||..|||...| .||| |.   ..| ||||..  |... ||..| | |. .. . | 
dkhryptvPckPstavev.ivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

ILVKFAQERK--TGDYIERTLNVSKNKanvgEEEDRRQITQYHYLTWKDFMAPEHPhgiIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALDSLIQQ
  .|  .. .    . ..|||.|        .. . | .| | | .| |   |.     ..    .. |    . ||.||||||.||. .... . | ..
fkikiknkelilnkkiskrtlevedst....gkfatrtvthyqysewtdrgvPksh...aelfdlmelvkk.sekPivvhcsaGiGrsvafigteylare

LEEEDSVSIYNTVCDLRHQRNFLVQSLKQYI
.| .  . . ... .||..|   ||  .|  
veadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 894-1155 8.5e-31 101.8 In-house 22-274 (312) alignment 
Range on Protein: 894-1155
Range on HMM: 22-274/312.0
LREYEMLPNRFSDRTTKnSDLKENaCKNRYPDIKAYDQTRVKLAVinglQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN
 .||  . | .||     . || .   ||||.|. .|. |  ||     .   || ||||      ..|.|.|||.|.|.  ||..        |..|. 
tkeykavgnivsdsect.aflkfk.dlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

LEEYNKAKCAKYWPEKVF-----DTKQFGDILVKFAQERKTGDYIertlNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIrqinSVYSL
. |    |||||  . |      | . . .   .     |. | |         |  |    .  .. .| . .| |   |.      ...    |    
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdki....thrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll....savkk

QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
.. |.. ||||||||||||. ..|.|  |       . ..   ||..|   |. . ||..  |..|.
dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1188-1448 9.9e-30 98.4 In-house 10-292 (297) alignment 
Range on Protein: 1188-1448
Range on HMM: 10-292/297.0
EVEFEKLLATADeiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPmrENSTYINASFIEGYDNSE--TFIIAQDPLENTIGDFWRMISEQSVTTLV
| | . ||  |   ..| |.   .    ||| ..|. .| .|| |   .   .. |||| ..   |. .   .|.|| ||..|. |||... || | ..|
eaekdllldear..gesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrviv

MISEIG-DGPRKCPRYWAD---DEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVP----EVCRG-------------I
|....  ||  ||  || .   .  .  ...|... | |  . .     ..    ... .|.  |. .||  |  ||    .. |              .
mvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswp..dhGvpsdledlvrfqaqvcscciavpmm

IELVD----QAYNHYKNNKNSGCR-SPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
. ||.      .   .  .    |  .| |||| |  || . |   .... || ..  |. |  ..||.||. |...  |.|.|. |..
lalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
0046846 (Phosphotyrosine protein) phosphatases II 1232-1450 1.1e-29 98.8 In-house 3-172 (176) alignment 
Range on Protein: 1232-1450
Range on HMM: 3-172/176.0
LTPLPMRENSTYINASFIEGYdnseTFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADdEVQYDHilvkyvhsescpyytrrefy
|..|  .....||||..| |.     .|. | ||..|. ||..|. |. .|..|.. |  .  | |||.|| . . ....                    
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi....................

vtnckiddtlkvtqfQYNGWPTVDGEVPEVcRGIIELVDQAYNHYKNNknsgcrSPLTVHCSLGTDRSSIFVAmCILVQHlrlEKCVDICATTRKLRSQR
               ||  .|..|. ||.  . ..||... ....|..       |  |||| |  |.  .|| . |...   ||....  . ...|.||
...............qylhlpwpDhgvpdl.elllellefirealkeg......gpvlVHCsaGigRtgtlva.ayllel...ekglsveealalvreqR

T-GLINSYAQYEFLHRAIINY
  | . . .||.||....  .
plgavqtpeQyrflyefelll
0036282 (Phosphotyrosine protein) phosphatases II 1241-1444 3.9e-29 97.0 In-house 2-163 (174) alignment 
Range on Protein: 1241-1444
Range on HMM: 2-163/174.0
STYINASFIEGYDNSETFIIAQDPLEntigdFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADdevqydhilvkyvhsescpyytrrefyvtnckIDDT
|.|||||.. ..  .. .|. | ||.     ||.|. |...||.||  |       ||..|| .                                  . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

LKVTQFQYNGWPTVDGEVPEVCRgIIELVDQAYNHYKNnknsGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRlEKCVDICATTRKLRSQRTGLINSYAQ
|. . .||  .|..|..||..   ..|.|.........    .   |. |||| | .|. ..||. .. ..|. |. ||.... |.||.|| | . .  |
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YEFLH
|.||.
yrfly
0043147 (Phosphotyrosine protein) phosphatases II 1239-1444 2.4e-28 94.4 In-house 3-154 (172) alignment 
Range on Protein: 1239-1444
Range on HMM: 3-154/172.0
ENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIgdgprkcprywaddevqydhilvkyvhsescpyytrrefyvtnCKIDD
|.|.|||||....|     ||. | || ||. |||||. |. .|..|.. |                                            ... .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

TLKVTQFQYNGWPTVDGEVPeVCRGIIELVDQAYNHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVqhlrleKCVDICATTRKLRSQRTGLINSYA
 |. . .||  .|  |. ||   . ..|.... .... ....     |  |||| | .|.  .||. ..       .....  . . .|..| | . .  
llerlgiqylylpwpDhgvp.llellleflefidellalspg....gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYEFLH
|| ||.
qyrfly
subfamily_CG42327_pd Subfamily CG42327 918-1088 2.6e-28 93.6 In-house 27-199 (319) alignment 
Range on Protein: 918-1088
Range on HMM: 27-199/319.0
AC--KNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKER-KKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKV--FD
..  |.|. ..    .||| |  |   . . |..|..| ||..    .|.|| ..|..  ||||..|||   .|| ||.| |    .||.|.| |    .
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TKQFGDILVKFAQERKTGDYIERTLNVSKnkanVgEEEDRRQITQYHYlTWKDFMAPEHPHGIIKFIRQINSV---YSL
|. .||||| . .      |.  || . .    | ..|  |..| | |  | .   | ..  .|  . ...|    |||
tslyGdilvtlkgrevkdryaistlllkr....v.dkeesrelthywy.kwleaevPaeeaaliamllevrsslksysl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1179-1450 1.4e-27 91.5 In-house 10-276 (307) alignment 
Range on Protein: 1179-1450
Range on HMM: 10-276/307.0
KPNEGKCKLEVEFEKLlatADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISE
  . |  .|  ||..|   |.   .. .|   . |. ||| |..   |..|....       | || | ..    .   || || |||||. .|| |. .
tldkgvqalvdefrvl...akktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiq

QSVTTLVMISEIG-DGPRKCPRYWADDEVQYdHILVKYVHSESCPYYTR-------REFYVTNCKID---DTLKVTQFQYNGWPtvDGEVPEVCRGIIEL
. | ...|. ..   .  || .||  .| |   . ..  .. |                 ||. |.|   ..  ....|.. ||  |  ||..  . |.|
ekvesvimlckvielakikceqywpleegqk.lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwp..drgvpqinltainl

VDQAyNhYKNNknsgcrsPLTVHCSLGTDRSSIFVAMCILVQ-HLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
..   . |..|       |. |||| |  ||   ||.... .  .. . | |.    ..|||||   |.. ||| .||| ...|
leav.r.ydtn.......pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1187-1455 1.4e-27 91.2 In-house 24-291 (305) alignment 
Range on Protein: 1187-1455
Range on HMM: 24-291/305.0
LEVEFEKLLAtADEISKSCSVGENEEnNMKNRSQEIIPYDRNRVILTPLPMrenSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVM
|  ||  .    ... |  .  | .| . ||| ...   |.||| | .        || | ..    |.. || .| |||.|  ||| |  .. | .. |
lraefvamkr.fndfekmkafkeaqe.agknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifm

ISEI-GDGPRKCPRYWAD---DEVQY----DHILVKYVHSESCPYYTRREFYVTNCKI------DDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAy
. ..   | .||  |.|    |....    ..| ||.  |..  . .  .  ||. ..       ...|||.. .. ||  |  ||     |.||. .| 
lcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwp..drgvpaadlailelleka.

nhyknnknSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRL-EKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLHH
           . |..|||| |  |.   | .  ... |   ..  |     .|.| ||   |.. ||| |.|. |.||   ..
........rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkk
subfamily_ptpA1_pd Subfamily ptpA1 1181-1411 4.6e-27 89.8 In-house 15-256 (418) alignment 
Range on Protein: 1181-1411
Range on HMM: 15-256/418.0
NEGKCKLE--VEFeKLLATADEiSKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDnSETFIIAQDPLENTIGDFWRMISE
|  ||  .   || .||  .       | |... |  |||  .|.| .. || |  .  .| | |||| .|.|    . || .| || ||| |||||. |
nhikcihkikeef.rlleesvg.psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwe

QSVTTLVMISEIGDGPR-KCPRYWADDEV--QY------DHILVKY-VHSESCPYYTRREFYVTNCKI---DDTLKVTQFQYNGWPtvDGEVPEVCRGII
. .  .||.|   .  | || ||| ..    |.      . ..  | |          ||    | ..    .|  .||.||.|||  | ..|.  . . 
nrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwp..dhnipdhtqpfr

ELVDQAYNHYKNNKNSGC-RSPLTVHCSLGTDRSSIFVAMCILVQHL
.|.    |. ..   |     |. |||| |  |.  |..  |....|
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 909-1150 4.8e-27 89.8 In-house 10-252 (290) alignment 
Range on Protein: 909-1150
Range on HMM: 10-252/290.0
TKNSD-LKENACKNRYpDIKAYDQTRVKLAVINGLQTTDYINANFVIgYKERKKFICAQGPM-------ESTIDDFWRMIWEQHLEIIVMLTNLEEYNKA
....| .|... ..|. ..    .||| | .     . ||| ||.|. . .  ..|  | |        .||| .|| |. . . . .||| . || .. 
llktdyvkkhemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksan

----KCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKanvgeeEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINsvysLQRGPILVH
     |||| ||.| .  .|... ||  .  |  | ..|.| |  ..      |   ..| . .  |..  ..|..  ... |....     .. |..||
tslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd......eeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivH

CSAGVGRTGTLVALDSLIQQLE-EEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLY
|  |. |  .| |..   | .   ..||.. . . .||.||. ...| ... |  
cvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd
PTPc_DSPc_SM00012 1341-1448 9e-26 85.5 In-house 1-104 (105) alignment 
Range on Protein: 1341-1448
Range on HMM: 1-104/105.0
KVTQFQYNGWPTVdgEVPEVCRGIIELVDQAYNHYKNNKNsgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLE-KCVDICATTRKLRSQRTGLINSYAQ
.|....|.|||    .||| .  |.||...  ........   ..|. |||| | .|. .|||..||.|.|. | |.|||. . ..||.|| |......|
tvkhyhytgwpdh..gvPeesdsilellravkknknkses...skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq

YEFLHRAII
| ||.||..
ylflyrall
0048076 (Phosphotyrosine protein) phosphatases II 1005-1153 1.2e-25 85.3 In-house 2-139 (145) alignment 
Range on Protein: 1005-1153
Range on HMM: 2-139/145.0
YWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVsknkaNVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQrGPILVHCSAGVGRT
||| ....   .|.. .    |.     | . ||.        .|   |...||.|| | |. .|. .  ...|...|.....   ||.|||||||||||
ywpseilpglylgslptaldlellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRt

GTLVALDSLIQqleeeDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
|||||.. ...      .||.....  .| || . |..  |..|||...
gtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 916-1155 2.6e-25 83.5 In-house 47-342 (349) alignment 
Range on Protein: 916-1155
Range on HMM: 47-342/349.0
ENACKNRYPDIKAYDQTRVKLA-------VIN-------GLQTTDYINANFVI--GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNK
|  .|||| ||  |. .||||        ||.       . .  ||||||..    ..  ||.|. | |. ||.|||...|  . ..... |.. .| . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

AKCAKYWPEKVFDTKQF------------GDILVKFAQERKTG---DYIERTLNVSKNKANVGEEEDRR---QITQYHYLTWKDFMAPEHPHGIIKFIR-
 || .|| |  .. ..                 ... ....|    | ...  .  ..  .     . .   .. |  .  | |      |  |.. .  
ekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalev

------QINSVYS---LQRGPILVHCSAGVGRTGTLVALDSLIQ--QLEEEDSVS----------IYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
      . ..       |  ..||||||| ||||.|| ||.|..  .  ...|.           |. .|  || ||  .|| |.|.|..| ||| 
kndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 911-1154 3e-25 83.2 In-house 45-282 (302) alignment 
Range on Protein: 911-1154
Range on HMM: 45-282/302.0
NSDLKENACKNRYPDIKAYDQTRVKLAVinglQTTDYINANFVIGYKERKKFICAQGPMESTI---DDFWRMIWEQHLEIIVMLTNLEEYNKaKCAKYWP
 .  |.|  ||. .|....|...|||.     .  .|.||  |   . ... | || |  ..    ..||||.....   .|.|   || .|    ...|
Ckafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfp

EKVFDTKQFGDILVKFAQERKTGDYI-ERTLNVSKNKANvgeeeDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGT
.|  | |..|.. |   .  |. .   . .. |  .        .   .. |.   ||.   |..   .|| . ..    .    ....    |.|| |.
kksgdykeygkmfvNnrkVekaeeektryviEvlPegcs.....nsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRaga

LVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
...|   ...|.... . | ..|  .| ||   |.|||||..||.|||
fltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1212-1451 3.5e-25 83.2 In-house 55-283 (290) alignment 
Range on Protein: 1212-1451
Range on HMM: 55-283/290.0
ENNMKNRSQEIIPYDRNRVILTPlpmRENSTYINASFIEGYDNseTFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPRYWADDEVQ---
 .  ||| ....  |. ||||       .  |. | ...| .   .||..| .|..|. |.|||. .. |...||. | | ||  || .|. . | .   
tefkknrykdvvcndktrvilkd...GydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YDHILVKYVHSESCP-YYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVdqaynhYKNNKNSGcrsPLTVHCSLGTDRSSIFVAMCI
. .| |    ...      .. . | . .     |.  ..   ||  |  |.     .. ..      .   | ||   |..|||| |  |.  |||. .
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp..dksvalstlallrtl......rilrkasG...pvvvhcsaGiGrtGtfvaiev

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYS
 .| |   | .|.  . | ||  | . ..   ||  | ...... 
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 957-1151 4.3e-25 83.0 In-house 2-198 (199) alignment 
Range on Protein: 957-1151
Range on HMM: 2-198/199.0
KERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeEEDRRQIT
| ....|..| |.  |. |||.|.||     |||. . .  ..|  . |||     | ..| . |         ||   .| ...| .        |.|.
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta...ppstreis

QYHYLTWKDFMAPEHP--HGIIKFIRQINSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQLEEED--SVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
.| . .||.  .|.     |..   |..   |  ..  |..|||| | | || .||||  ..  ||     | ...    ||  |  .. ||..| |.|.
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 958-1151 6.6e-25 82.4 In-house 2-197 (198) alignment 
Range on Protein: 958-1151
Range on HMM: 2-197/198.0
ERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANvgeEEDRRQITQ
 ....|..| |.  |. |||.|.||     |||. . .  ..|  . |||     | ..| . |         ||   .| ...| .        |.|..
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta...ppstreish

YHYLTWKDFMAPEHP--HGIIKFIRQINSVYSLQR-GPILVHCSAGVGRTGTLVALDSLIQQLEEED--SVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
| . .||.  .|.     |..   |..   |  ..  |..|||| | | || .||||  ..  ||     | ...    ||  |  .. ||..| |.|.
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 963-1149 9.3e-25 81.7 In-house 92-280 (302) alignment 
Range on Protein: 963-1149
Range on HMM: 92-280/302.0
IC--AQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQ-ERKTGDYIER---TLNVSKNKANVGEEEDRRQIT
.      |  ||.. .| .| . .  |.| |... | .. |||.|. .|| .. .||   ||  . . .  .. ..   .|   . | .  ... .. . 
vskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvd

QYHYLTWKDFMAPEHPHGIIKFIRQINSvYslqRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFL
  .. .| |  ||....  .. ..  .| |   .  .||||||||||||||||.   ||   ...   . . |. .|. |   ||. .| |.|
ilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
0044763 (Phosphotyrosine protein) phosphatases II 1224-1446 2.3e-24 81.4 In-house 1-166 (178) alignment 
Range on Protein: 1224-1446
Range on HMM: 1-166/178.0
PYDRNRVILTPLPMRENSTYINASFIEGYdnsetFIIAQDPLEntigDFWRMISEQSVTTLVMISEIGDGP-RKCPRYWADDEVqydhilvkyvhsescp
|.||.||.|..|.. | | |||||.| ..     ..... | .    |..... |. .|..|...|   ..  ||..|| ...                 
pldrtrvllsnleglersdyinaseilpg.....lylgslppa....ddlellkelgithivnlteelelgflkcdpywpeeag................

yytrrefyvtnckiddtlkvtqFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYK-NNknsgcrSPLTVHCSLGTDRSSIFVAMCILVQHlrlekCVDICA
                      .||  .|..|. ||.. . . |.|.   .... ..      .|  |||| | .||  .||. .. ..      ... .
......................iqylhipipDhgvpdllehflefvefieealdekg......gpvlVHCsaGvgRsgtlvaaylmkkl.....glslee

TTRKLRSQRTgLINSYAQYEFLHRA
  . .|..|   . .  |...|.. 
aielvrerRp.ivpnpgqlrqLyef
0049260 (Phosphotyrosine protein) phosphatases II 1248-1444 4.6e-24 80.2 In-house 1-143 (152) alignment 
Range on Protein: 1248-1444
Range on HMM: 1-143/152.0
FIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDG-PRKCPRYWaddevqydhilvkyvhsescpyytrrefyvtnckiddtlkvtqfQ
||.|| ..  ||..| |..||. |||||. |. .||.||. |  .    ||..|.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNsgcrsPLTVHCSLGTDRSSIFVAMCILVqhlrleKCVDICATTRKLRSQRTGLINSYAQYEFLH
|  .|. |. ||.    ...|..    .......     |  |||| | .|.  .||. ..       . |..  . . .|..| | . .  |..||.
ylhlpwpDhgvpdlsqlllflllfieklaldkgg.....pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0048179 (Phosphotyrosine protein) phosphatases II 1005-1151 8.8e-24 79.3 In-house 2-139 (144) alignment 
Range on Protein: 1005-1151
Range on HMM: 2-139/144.0
YWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRT
..| ....   .|.. .    |.     |   .|.. .      |.  |...||..| | |. .|.... ...|.. |..... . ||.|||||||||||
snpseilpglylgslptaldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRt

GTLVALDSLIqqleeEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYR
|||||.. ..     .  .|.....  .| .| . |..  |..||..
gtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1211-1450 3.5e-23 76.7 In-house 53-288 (305) alignment 
Range on Protein: 1211-1450
Range on HMM: 53-288/305.0
EENNMKNRSQEIIPYDRNRVILTPLPmreNSTYINASFIEGYD-NSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPRYWADDEVQ-
. .  ||| |..   |.. | |   .    | || | ..         || || ||..|| .|| |. .. |  .||.   .  |  || .||     . 
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

--Y-DHILVKYVhSESCPYYTRREFYVTNCKI----DDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnknSGCRSPLTVHCSLGTDRSSI
      |.|. | | | |     |  .|  ..    |... | ..|.. ||  |  || .    .||.             | . |. |||| |  |.  
lelksgivvenv.sgskpmerdaeiqitllnltysgdqkmsvrhlqwtewp..drgvppckltslellsai.........rgskvpivvhcsagigrtgt

FVAMCILVQHLR-LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 ||.  .....    .|  .    . || ||.  |..  || |.|| ..||
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1051-1192 6.6e-23 75.7 In-house 87-230 (440) alignment 
Range on Protein: 1051-1192
Range on HMM: 87-230/440.0
DRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV-YSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFL
. | . ||||  | |   |.    ..|.|...|        ||.|||||||.|||| ..|.||.... .  | . |.. .  .| .|  .||. .|| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YRALLDTGTFGNTDICIDTMASAIESLKR-KPNEGKCKLEVEFE
. |.|.    |.| |  | ..  .| ..  .|.  |. |. |||
heavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 971-1154 1.5e-22 74.9 In-house 38-218 (255) alignment 
Range on Protein: 971-1154
Range on HMM: 38-218/255.0
S-TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQerKTGDYIERTLNVSknkANVGEEEDRRQITQYHYLTWKDFMAP
| |.| |...|  .  | .|||....| .. || .|.| .  . ... |. |  ..   . | . |||..    ...||    .... |.|  | . .||
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleit...stlgekkkthtvkhysykGWieknaP

EHPHGIIKFIRQINSVyslqrGPILVHCSAGVGRTGTLVALDSLIQ----QLEEEDSVSI--YNTVCDLRHQRNFLVQSLKQYIFLYRALL
| .. | . .. .         ...||||.|.||. ..|  ... |    .|.. . | .   . . .||..|.  ..   |  |    .|
elareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
0051082 (Phosphotyrosine protein) phosphatases II 1241-1447 7.9e-22 72.9 In-house 3-149 (151) alignment 
Range on Protein: 1241-1447
Range on HMM: 3-149/151.0
STYINASFIEGYdnsetFIIAQDPLEntigDFWRMISEQSVTTLVMISEIGDGPrKCPRYWADDEvqydhilvkyvhsescpyytrrefyvtnckiddtL
|.|||.|...|.     ... . ||.    ||.... |. ..| |.. .    . .||.|. . .                                  .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................i

KVTQFQYNGWPTVDgeVPEVCRGIIELVDQAYNhyknnknsgC-RSPLTVHCSLGTDRSSIFVAMCILVQHlrlekcVDICATTRKLRSQRTGLINSYAQ
.|..... .||. .  .|.    ..|..... .         .   |. |||| | .|. ..||. .. ..      |.. .. . .|..|.|....  |
evlhipildwpdpg..lplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YEFLHRAI
. |...|.
flfqlfal
subfamily_CG42327_pd Subfamily CG42327 1193-1376 1.5e-21 71.4 In-house 16-195 (319) alignment 
Range on Protein: 1193-1376
Range on HMM: 16-195/319.0
KLLATADEISKSCsvgeneenNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSET-FIIAQDPLENTIGDFWRMISEQSVTTLVMISEIG
.|.| |||.  ..        . |.|  ...|    ||.|   .  ... |..||.. |||.... .| || .||..  ||||.. ||   ..| .... 
qliaradevPvts........kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

D-GPRKCPRYWA-----DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYnGWPtvDGEVPEVCRGIIELVDQAYNHYK
. | ..|..|.      |..  | .|||   . |.   |    . . . . . . ..| . |  |.  . |||   . .| .. .. .  |
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwl..eaevPaeeaaliamllevrsslk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 897-1161 6.1e-20 66.0 In-house 28-282 (303) alignment 
Range on Protein: 897-1161
Range on HMM: 28-282/303.0
YEMLPNRFSDRTTKNSdLKENACKNRYPDIKAYDQTRVKLAvinglqTTDYINANFViGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEE
.| . . .  . .||  . .|  |||. |.   |...|||.       . || |...   . .|| | .| |.  |  |||.|| ||..  ...|    |
fekvvsylppsvsknq.fvknmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdse

YNKAKCAKYWPEKvFDTKQFGDILVKFAQERKTGdyIERTLNVskNKANVGEEEDRRQITQYHYLTWKDFMAPEH-PHGIIKFIRQINSV---YSLQrGP
|.|      .|..  |  .| .  ..  . ..    .    ..  .   | . . .  .  .|| .|     | .    ..| | |..||   ||    |
ydklggdsvfprn.qdflkfeersirvgefkrve..lgdgwvl..kvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds.tp

ILVHCSAGVGRTGTLVALDSLIQQLE-EEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRaLLDTGTFGN
 .    .|.||.||.  ...    |  |. |. . . .  .|  |   || | |. ..|  ||    ..|
tvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt.llaehvldn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1197-1450 1.8e-19 64.5 In-house 21-268 (281) alignment 
Range on Protein: 1197-1450
Range on HMM: 21-268/281.0
TADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTP-LPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR
  |  |  |.| ..  || |||  .|   |  || |   .| .. . || | .|        .|..| | ..|  |||||| ..  |..||. .. .  |
pgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr

-KCPRYWADD---EVQYDHILVKYVHSESCPYYTRREFYVtnCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnknSGCRSPLTVHC
 ||  |.  .    .|.|.. |.|  |          . .      .|  .|.. .. ||  | .|||    ..... .              .|  .||
ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewp..dwqvpessevmlkilrki.........rarstppvihc

SLGTDRSSIFVAMCILVQHLRLEK-CVDICATTRKLRS-QRTGLINSYAQYEFLHRAIINY
| |  ||  ..|. | .| ..      ||     .||   |.  ...  || .. . ....
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_hpo-7_pd Subfamily hpo-7 970-1150 6.9e-19 62.8 In-house 44-220 (263) alignment 
Range on Protein: 970-1150
Range on HMM: 44-220/263.0
ESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKtgDYIERTLNVSKnkaNVGEEEDRRQITQYHYLTWKDFMAP
  ||| |...|  .  | .|||.. .| .. || .|.| .  . ... .. |  ..  .  | . .||.. .   ..||    .....| |  | . ..|
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlells...tlgeKkkthtvkhysykgWiekndp

EHPHGIIKFIRQINSVyslqrGPILVHCSAGVGRTGTLVALDSLIQ----QLEEEDSVSI--YNTVCDLRHQRNFLVQSLKQYIFLY
| .. |.. ..           .. ||||.|.||.   .  ... |    .|.. . | .   . . .||..|.  ..   |  |  
elareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
subfamily_egg_pd Subfamily egg 1196-1450 7.5e-19 62.5 In-house 25-270 (307) alignment 
Range on Protein: 1196-1450
Range on HMM: 25-270/307.0
ATADEISKSCSVgeNEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDgPR
 ..||||   ..  ...|  | ||. .   |  || |     .    .| |  ..|    ..||.|| || ||  |||||. .. |  .||..   . . 
esvdeislttaa..sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrke.se

KCPRYWADDEVQYDHILVKYVHSEScpyytrrefYVTNCKIDDTLKVTQFQYNGWPtVDGEVPEVCRGIIELVDQAYNHYKNN-KNSGCRSPLTVHCSLG
.|. ||   | .   ..   .. |.         .  . | |  ..||...  |    .    |  .| .. . . |  ..   |      |  |.. ||
rceyywpkaesdslvtvpGslrien.........lkvdskadplfrvtklklvGgd.deerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilG

TDRSSIFVAMCILVQHL-RLE-KCVDICATTRKLRSQRTGLINSYAQYEFLHRAII-NY
  ... .||. | . .| |       .  .   || .|   ..|  .| |..| ..  .
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1213-1448 5.5e-18 60.1 In-house 19-256 (290) alignment 
Range on Protein: 1213-1448
Range on HMM: 19-256/290.0
NNMKNRSQEIIpYDRNRVILTPLPMRENSTYINASFIEgYDNSETFIIAQDPLEN-------TIGDFWRMISEQSVTTLVMISEIGDGPRK-----CPRY
..|..| .  .    .||.|     | |. || |...  . |   .|. | |.|.       || .|| |. .  |. .||. |  .  ..     | .|
hemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

W---ADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKiDDTLKVTQFQYNGWPTVdgEVPEVCRGIIELVDQAynhyKNNKnsgcrSPLTVHCSLGTDR
    ...|.... . ||  . |      .||  |.  . .  ..||  ...|| ..  .|.|  . ...|...     |..|     .|  |||  |  |
vpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnkl..nvqedtktllsliqkv....kask.....tpvivHcvdGiSr

SSIFVAMCILVQHLR-LEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAII
| .. |. .  | .  ... | . .   .||.||  .| |. .. |   .|.
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1209-1459 7e-18 59.2 In-house 48-299 (310) alignment 
Range on Protein: 1209-1459
Range on HMM: 48-299/310.0
ENEENNMKNRSQEIIPYDRNRVILTPLPMReNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIG-DGPRKCPRYWADDEVQ
  ...  |||  ...  |  || |.    |    || | ..      .||| .| ||. || |||||| ..   .....  .| .|  ||  ||    | 
aykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

--YDHILVKYVhSESCPYYTRREFYV----TNCKIDD------TLKVTQFQYNGWPtvDGEVP-EVCRGIIELVDQAYNHyknnknsgcrSPLTVHCSLG
  |  | |  . |||   .   .. |     |  .|.       |.|.  ..  ||  |  || | |  . . .     |           |  |||| |
etygcirvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwp..drgvpdekchtvpqrllaqvrh..........gpcvvhcsag

TDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY-SDLHHIAES
 ||  . ||. . ...|.  . ||.     .|. .|.  |..  || ...|  | .    ...||.
kdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetevaek
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1212-1450 9.2e-18 59.3 In-house 42-270 (288) alignment 
Range on Protein: 1212-1450
Range on HMM: 42-270/288.0
ENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEI-GDGPRKCPRYWADDEVQYDH
.|  ..| ...   |  || |.     .   ||.|  .    . . .| || ||. ||. .|.|. |. |  .||..|.   | .|   |.     .  .
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

ILVKYVHSESCPYYTRREFYVTNCKIDDTLK----VTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnknSGCRSPLTVHCSLGTDRSSIFVAMCI
|               .   |.  .|  . .    | .  .. |.  |  |||     . |..             .. |. ||.| |. |.  .. . |
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWd..ddgvPenylsplrllevl.........kslqkPivvhssaGvGrtgtlilili

LVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 .. |||.  . |     ||| .|   |..  || ..|| . ..
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1184-1452 1e-17 58.5 In-house 25-286 (302) alignment 
Range on Protein: 1184-1452
Range on HMM: 25-286/302.0
KCKLEVEFEKLLATADEISKsCSVGENeeNNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTI---GDFWRMISEQS
. ... ||.|. ..  .. | |..  .  |  ||.|...  .| |.|.|.     |.  |.||| .|  . ... |.|| |  ..     .||||. ...
taevkkefkkidtmkvdlek.Ckafkk..nlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

VTTLVMISEIGDGPRKCPRYWA---DDEVQYDHILVKYVHSESCPYYTrREFYV--TNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhy
....|..    .  .    ..    .| ..|... |     |.    .  ....      . ... ..    . |.  . .||.    .|. . .     
ivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWk..qkkvpvkyaeliktaakv....

kNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
  .|.. . ... .    |. | ..|... . |..|  .| . |  . ...||||.  ..|. || .|..|.. |  
.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_CG42327_pd Subfamily CG42327 1088-1153 2.3e-17 57.6 In-house 245-311 (319) alignment 
Range on Protein: 1088-1153
Range on HMM: 245-311/319.0
LQRGPILVHCSAGVGRTGTLVALDSLIQQLEEE-DSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL
 ..||. |||| ||||||...| |  |..|||   || | ..|  .|..|   |.. .|| |.|. |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1244-1439 7.9e-17 55.9 In-house 78-269 (301) alignment 
Range on Protein: 1244-1439
Range on HMM: 78-269/301.0
INASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISE-IGDGPRKCPRYWA---DDEVQYDHILVKYVHSESC--PYYTRREFYVTNCKI-
| | .|.   ... ||..| ||.||  ||| |.    | ..||... . .  .||  | .    .... .   .| ...|.      ..|.. |..    
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

DDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyknnKNSgcRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINS
 .|  || .||. |.  | .||.    . .|.. .       |.|  . |. |||| |  ||  |..  .| ...  .. ...  . ..|| .|   .. 
fatrtvthyqysewt..drgvPkshaelfdlmelv.......kks..ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt

YAQ
  |
nsq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1204-1452 8.7e-17 56.0 In-house 26-271 (285) alignment 
Range on Protein: 1204-1452
Range on HMM: 26-271/285.0
SCSVGENEENNMKNRSQEIIPYDRNRVILTplpmRENSTYINASFIE--GYDNSeTFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRY
 |.    | |   ||  ..   .  ||.|       .  || ||..   | |.| |.| .| || .|. |||.|| .. .. ..|.  . . |  ||  |
nctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WADD---EVQYD--HILVKYVHSESCPYYTRREFYVTNCK--IDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELvdqaYNHYKnnKNSGCRSPLTVHCSL
. .     |..    | .  .. |.        . |.| .    . | . . |   ||  |   || .| .|||    |.  |  |      |. |||| 
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwp..dqlapedarpmiel....ykwvk..kvnpkekpicvhcsa

GTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
|  |.. || .     ..  .  ...    |..|. |   ..|. |. ||.  ...|  
gvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_eak_pd Subfamily eak 1203-1450 1.5e-15 51.5 In-house 42-304 (332) alignment 
Range on Protein: 1203-1450
Range on HMM: 42-304/332.0
KSCSVGENEENNMKNrSQEIIPYDRNRVILTPlPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMIS-EIGDGPRKCPRYW
.| |...  |.  .|   .|.||||. | ||.  ....  ||||| .|  .  . .|..  . |. .  ||.|. ||   ..|..  ..  .  |  .|.
lsisetarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

ADDE---VQYDHILVK---YVHSEscpYYTRREFYVTncKIDDTLKVTQFQYNGWPTVDGEVPE-------VC--RGIIELVDQAYNHYKNNKNSGCRSP
 |.    ... .. |.   .|. .    .  | . ..  | ..| .|  ... ||  ..  . |       |    |.. |.  . . ..   .    .|
pdktreelkfGildverkefvkrn...iletrllels..kGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtp

LT----VHCSLGTDRSSIFVAMCILVQHL--RLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 .    . .. |. |. .|| . .|.. .  . .    .     | .|.|   .    |. |.. ....|
psfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_eak_pd Subfamily eak 907-1155 1.7e-15 51.3 In-house 42-303 (332) alignment 
Range on Protein: 907-1155
Range on HMM: 42-303/332.0
RTTKNSDLKENACKNrYPDIKAYDQTRVKLAViNGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYW
.. ....  |.  .|   .|  ||.  |.|.    |    ||||  .   .  .|.| .  . |. .  ||.|. ||.   ||.| .  | .  |  ||.
lsisetarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSK-NKANVGEEEDRRQITQYHYLTWKDFMAPEH---PHGIIKFIRQINSVYSL--QR--------GP
|.|  .  .|| . |.  .  | . .  | | .|| |..           |..    ..||.|  .     |....|   ....|   ..         |
pdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap

IlVHCSAGVGRTGTLVALDSLIQQLEE--EDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD
| . .. |  |.|..| .| ||. ...  ... |. . .   ...|.  |   .|. |.| ..||
i.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivld
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1207-1314 2.6e-15 51.0 In-house 41-161 (350) alignment 
Range on Protein: 1207-1314
Range on HMM: 41-161/350.0
VGENEENNMKNRSQEIIPYDRNRVILT--PLP------MRENSTYINASFIEGY-----DNSET-FIIAQDPLENTIGDFWRMISEQSVTTLVMIS-EIG
. |  |   ||| ..|.||...||.|   . .        . . ||||....        |..  .| .| || .|. ||...| .  |. ..... .. 
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

DGPRKCPRYWADDEvqYDHILVK
 . .|| ||| . .  || | ||
lnlekcyrYWqegs..ydditvk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1191-1289 3.3e-15 50.4 In-house 17-118 (347) alignment 
Range on Protein: 1191-1289
Range on HMM: 17-118/347.0
FEKLLATAdeISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPM-----RENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV
|.. ||.       ... | | .  ||||..    |  ||.|.|         .  |||||| |   . |. .|..| || .|. |||.|.|   || .|
fdenlany..spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

MISE
 | |
tife
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1217-1450 5.2e-15 49.9 In-house 47-275 (312) alignment 
Range on Protein: 1217-1450
Range on HMM: 47-275/312.0
NRSQEIIPYDRNRVILTplpmRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMIS-EIGDGPRKCPRYWADdEVQYDHILVKY
||  .|  .|| |  |.     ..  || | |.    . | |...| |||||.  ||..    . |......  . ||  || .| .|  | . ..  . 
nrypniqcwdrgrftla....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd.ivgfvdledhr

VHSESCP----------YYTRREFYVTNCKIDDTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAynhyKNNKNsgcrsPLTVHCSLGTDRSSIFVAMC
|..|.|             | | . |      .  |. ..|.  ||  |  .|. |     |.       |..|.     |.  ||| |  |.  .. . 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswp..dhgmpdscdtalrllsav....kkdkk.....pviahcsagvgrtgtlalie

ILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
 ..  ||  .  ..  .   || .|.  .. ..|| .  |.....
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1256-1444 7.6e-15 49.6 In-house 5-197 (199) alignment 
Range on Protein: 1256-1444
Range on HMM: 5-197/199.0
ETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADDEV---QYDHILVKYVHSESCPYYTRREFYVTNCKI--DDTLKVTQFQYNG
  .| .| || .|. |||.|. |     .||. .         | ||.  |    .|  . |      . | ||   . .||       | .....|.  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPTVDgeVPEVC--RGIIELVDQAYNHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK--CVDICATTRKLRSQRTGLINSYAQYEFLH
|       |.|.   |..    .  ..|...|.    .|. |||| |   . .|||. | |.     |   ||.   ...||  | |.| |  .|.|..
wkekt..tpnvalfvgfvvasrevskkyeqekd....apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1257-1444 8.2e-15 49.5 In-house 5-196 (198) alignment 
Range on Protein: 1257-1444
Range on HMM: 5-196/198.0
TFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYWADDEV---QYDHILVKYVHSESCPYYTRREFYVTNCKI--DDTLKVTQFQYNGW
 .| .| || .|. |||.|. |     .||. .         | ||.  |    .|  . |      . | ||   . .||       | .....|.  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PTVDgeVPEVC--RGIIELVDQAYNHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQHLRLEK--CVDICATTRKLRSQRTGLINSYAQYEFLH
       |.|.   |..    .  ..|...|.    .|. |||| |   . .|||. | |.     |   ||.   ...||  | |.| |  .|.|..
kekt..tpnvalfvgfvvasrevskkyeqekd....apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1210-1305 1.4e-14 48.3 In-house 93-182 (244) alignment 
Range on Protein: 1210-1305
Range on HMM: 93-182/244.0
NEENNMKNRSQEIIPYDRNRVILTPLPMreNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGprkcPRYWADDE
| .|. |||    .|.| ||| |.   |    |||||||.     .  .|..| || .|  |||.|. |. |  ||..  . .       || | |
npnnswknregaglpfdfnrvplskgsm..gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee....deywpdse
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 956-1155 1.8e-13 43.8 In-house 111-307 (346) alignment 
Range on Protein: 956-1155
Range on HMM: 111-307/346.0
YKERKKFICAQGP---MESTIDDFWRMIWEQHLEIIVMLTNLEEYnKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNkanvGeEEDR
..  .|.| || |    || ..||| ||........ ..   .   |   .  . ..    .  | ....  .   .||  | |..|  .    | . | 
fqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddkl.kntttslfndenggyqytgkmfinnrradvsgdpkeytievlpe....g.nsds

RQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRA
     .|.  || .  | .   |||.| |. |   .|   . |    | ||. ...     |.||..     |.. . ... ||   |.|. ||  .|  
vicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

LLD
..|
vfd
0048076 (Phosphotyrosine protein) phosphatases II 1334-1448 2.3e-13 45.6 In-house 37-140 (145) alignment 
Range on Protein: 1334-1448
Range on HMM: 37-140/145.0
CKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNnknsGcrSPLTVHCSLGTDRSSIFVAMCILVQhlrleKCVDICATTRKLRSQRTGL
.   . |. . .||  .|. | .||.  . ..|....  ...|.    |   |  |||| | .|.  .||.... .     . |..  . ...|||| | 
tselellerlgiqylylpwpDhgvpdllellleflefieealke....g..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpga

INSYAQYEFLHRAII
. .  |..||.... 
vpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 1333-1445 6.9e-13 44.0 In-house 48-139 (144) alignment 
Range on Protein: 1333-1445
Range on HMM: 48-139/144.0
NckiddtlkvtQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNknsgcrSPLTVHCSLGTDRSSIFVAMCILVqhlrlEKCVDICATTRKLRSQRTG
.           .||  .|. | .||.    ..|...   ......       |  |||| | .|.  .||.....     .. ...  . . .||.| |
e..........giqylhlpwpDhgvpdllellleflefieealeeg......gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpg

LINSYAQYEFLHR
 . .  |..||..
avpnpgqlrfLle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1091-1154 8.7e-13 42.8 In-house 229-292 (297) alignment 
Range on Protein: 1091-1154
Range on HMM: 229-292/297.0
GPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL
 ..||||||||||.| .|  | ....|  .    .   .  ||.||  |||.|.|. .|| | |
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
fn3 Fibronectin type III domain 340-425 1.2e-12 40.9 Pfam-A 6-85 (85) alignment 
Range on Protein: 340-425
Range on HMM: 6-85/85.0
VETTGSTASTITIGWNPPPpDLIDYIQYYELIVSESGEVPkvieEAIYQQNSRNL-PYMFDKLKTATDYEFRVRACSDLTktCGPWS
.  .. |....|. |.||. |  . |..||. ..|.|.      |   ....|.   ... .||  |.|||||.|... .  .||.|
lsvsevtstsltlsWsppk.dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngag..egpeS
fn3 Fibronectin type III domain 244-320 4e-12 39.3 Pfam-A 8-84 (85) alignment 
Range on Protein: 244-320
Range on HMM: 8-84/85.0
AKAVGANKIYLNWTVN-DGNDPIQKFFITLQEAGTPTftYHKDFINGSHT-SYILDHFKPNTTYFLRIVGKNSIGNGQP
...|..... |.|.   ||..||... ....|.|..   ..| | . ..| |..| . ||.|.| .|.   |  |.|..
vsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 915-1008 1.1e-11 38.8 In-house 94-180 (244) alignment 
Range on Protein: 915-1008
Range on HMM: 94-180/244.0
KENACKNRYPDIKAYDQTRVKLAviNGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNkakcaKYWPE
 .|. |||      .|  || |.  .|     |||| ||       ..| .| |.  |  |||.|. |.|....|.|  .|| .     .|||.
pnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1265-1435 2.5e-11 38.1 In-house 39-205 (255) alignment 
Range on Protein: 1265-1435
Range on HMM: 39-205/255.0
LenTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGevPEV
|  |.  |...|  .  ...||...  . |  || .|.    |.  .. .. |   .| . .    .|   |  .   | .|. ..|.||.   .  || 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna..Pel

CRGIIELvdqaynhYKNNKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQ----HLRLEKCVDI--CATTRKLRSQRTGLIN
 | | ..       .|  ..|    .. |||| |  ||. || . .. |     |.  . |..      ..|||.|.. |.
areilni.......lkvvrds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih
PTEN_1 1034-1109 3.3e-11 38.4 In-house 69-149 (196) alignment 
Range on Protein: 1034-1109
Range on HMM: 69-149/196.0
ERTLNVSKNKAN----VGEEEDRRQITQYHYLTWKDFMAPEhPHGIIKFIRQINSVYSL--QRGPILVHCSAGVGRTGTLVA
   .|.|  ...      .|| ...  .|. . ..|. ||   . ........ . ...  ... .|||| ||.||.||.||
tlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1094-1156 5.8e-11 36.6 In-house 2-64 (69) alignment 
Range on Protein: 1094-1156
Range on HMM: 2-64/69.0
LVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
.||||.| |||||..|.   . ..  |  | |.| |  .|  |  .|    .|||.. || ..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1338-1449 7.2e-11 36.1 In-house 87-192 (440) alignment 
Range on Protein: 1338-1449
Range on HMM: 87-192/440.0
DTLKVTQFQYNGWPtvDGEVPEVCRGIIELVDQAyNHyknNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSY
..  . |..|.|||  |  ||...  .......  |.   ...    .|| |||| |. |... .|.  .... .    .|| .    .|..|  .... 
esrtlkqyhyqgwp..dkgvpkfagpvlkmiqdv.ne...sqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

AQYEFLHRAIIN
 || |.| |...
eqyafvheavle
subfamily_CG42327_pd Subfamily CG42327 1384-1452 7.5e-11 36.3 In-house 247-316 (319) alignment 
Range on Protein: 1384-1452
Range on HMM: 247-316/319.0
RSPLTVHCSLGTDRSSIFVAMCILVQHLRLE-KCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD
. ||.|||| |. |. . .|  | ...|    . |||  .   .| .|.  . .  ||||... . .|. 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 915-1001 7.6e-11 36.1 In-house 32-117 (332) alignment 
Range on Protein: 915-1001
Range on HMM: 32-117/332.0
KENACKNRYPDIKAYDQTRVKLAVINGlqTTDYINANFVIGYKERKKFICAQGPMESTI-DDFWRMIWEQHLEIIVMLTNLEEYNKAK
 .|   || | . ..|..||.||  .|    |. ||..| || ..  .| || |..      ||||. |..  .|... ...| .| |
lnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1223-1358 1.8e-10 35.3 In-house 3-128 (130) alignment 
Range on Protein: 1223-1358
Range on HMM: 3-128/130.0
IPYDRNRVIltplpmreNSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGprkcPRYWADDEVQY---DHILVKYVHSE
.... .|.         . |||||||.   ...  .. .| || .|  |||.|. |. |  ||..  . .       || | |      ..|.|   . .
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee....deywpdsePlewyeediivtltdrd

SCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTvDGEVP
   .    .. . .  ..    .| ||   ||. ||  |
efknikasnleiesdlneshqaltmfqisnwps.dgttp
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1203-1262 1.9e-10 34.8 In-house 38-94 (95) alignment 
Range on Protein: 1203-1262
Range on HMM: 38-94/95.0
KSCSVGENEENNMKNRSQEIIPYDRNRVILTplpMRENSTYINASFIEGYDNSETFIIAQ
 . .||  | |  |||  .|.|||  ||.||    . .| |||| |..||   . .| ||
apytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 955-1021 2.2e-10 34.5 In-house 231-293 (440) alignment 
Range on Protein: 955-1021
Range on HMM: 231-293/440.0
GYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLeeyNKAKCAKYWPEKVFdTKQFGDILV
||  .. ||..| |..||. ||||.. . ..  |.|| .|   |   |. ||| .   .  || . |
gyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntr.svtfgpftv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1095-1156 2.5e-10 34.5 In-house 2-63 (69) alignment 
Range on Protein: 1095-1156
Range on HMM: 2-63/69.0
VHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDT
||||.| |||||..|.   . ..  |  | |.| |  .|  |  .|    .|.|.. || ..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 939-1033 8e-10 33.1 In-house 7-95 (130) alignment 
Range on Protein: 939-1033
Range on HMM: 7-95/130.0
INGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNkakcaKYWPEKVFDTKQFGDILVKFAqERKTGDYI
.. ||  .||||.||      .... .| |.  |  |||.|. |......|.|  .|| .     .|||.         ||.|  . .|.  ..|
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtlt.drdefkni
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1208-1287 1.3e-09 32.1 In-house 42-114 (303) alignment 
Range on Protein: 1208-1287
Range on HMM: 42-114/303.0
GENEENNMKNRSQEIIPYDRNRVILTplpmreNSTYINASFIEgYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMI
 .  .|  |||  ..|  |  .| |.      .|.|| ||..|  | |   |..| ||  |  |||.|| || |  ....
nqfvknmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 872-967 2.1e-09 31.4 In-house 4-95 (95) alignment 
Range on Protein: 872-967
Range on HMM: 4-95/95.0
PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDlKENACKNRYPDIKAYDQTRVKLAVingLQTTDYINANFVIGYKERKKFICAQG
|||   .     . | ..|  |  |.  ..       |  |  . |  |||. .|  || ||| |.     . .||||| || ||  .. .|.|||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgss.eanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 911-1034 2.4e-09 31.2 In-house 31-165 (347) alignment 
Range on Protein: 911-1034
Range on HMM: 31-165/347.0
NSDLKENACKNRYPDIKAYDQTRVKLAVINGLQ-----TTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLT------NLEEYNK
 .. . .  |||  | |  |.||| |.  .  .     .  ||||  .   . .|..| .| |. .|. |||.|.   ..  .| .        .||...
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefan

AKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIE
|  .   |     .|. |   |   |  .  . ||
atlslvapaptasskdigsspvpidqiarereqie
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 891-959 4.5e-09 30.1 In-house 22-89 (440) alignment 
Range on Protein: 891-959
Range on HMM: 22-89/440.0
YGFLREYEMLPNRFSDRTTkNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKER
  |  |. .||. .|. .   . | .|  |||| .| |||..|| |  ..|.  .||||| .. | . |
rafedewsllpsglsqpsd.iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1213-1298 5.5e-09 29.9 In-house 33-119 (332) alignment 
Range on Protein: 1213-1298
Range on HMM: 33-119/332.0
NNM-KNRSQEIIPYDRNRVILTPLPMREnsTYINASFIEGYDNSETFIIAQDPLEN-TIGDFWRMISEQSVTTLVMISEIGDGP-RKCP
|||  ||   .  .|..|| |.|   ..   . |||...|| .  ..|.|| |... |   ||||.||.  . .... .| .   ||.|
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
0038934 (Phosphotyrosine protein) phosphatases II 1057-1109 6.2e-09 31.3 In-house 81-134 (194) alignment 
Range on Protein: 1057-1109
Range on HMM: 81-134/194.0
QYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL-QRGPILVHCSAGVGRTGTLVA
.|. | ..|....     . .|.. .. ...  . | ..||| ||.||||||||
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1207-1315 9.5e-09 29.0 In-house 42-165 (349) alignment 
Range on Protein: 1207-1315
Range on HMM: 42-165/349.0
VGENEENNMKNRSQEIIPYDRNRVILTPLPM----RENS----------TYINASFIE--GYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV-MISE
. |  |   ||| ..|.||.  ||.|   .      ..|           |||| ...   ..  . .|  | ||  |. ||...|  . |  .. . ..
lseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLndd

IGDGPRKCPRYWAddEVQYDHILVKY
   . .|| .||   | .|. | || 
kelslekcdiywq..elsysnitvkl
Ig_2 Immunoglobulin domain 35-126 1.1e-08 27.0 Pfam-A 11-78 (80) alignment 
Range on Protein: 35-126
Range on HMM: 11-78/80.0
AEIGKNVSLECASENE---AVAWKLGNQTINKNhtrykirteplksnddgsE-NndsqdfikyknvLALLDVNIKDSGNYTCTAQT--GQNHSTEFQV
.. |.|| | |....     | |..........                  . .            | .  |. .|||.|||.|.   |.. |. ..|
vtegenvtLtCqapgnptpkvqwykdgeelsqs..................qna............lfipnvsaedsGtYtCrasnsegskqsnsvev
fn3 Fibronectin type III domain 452-532 2.2e-08 27.3 Pfam-A 11-83 (85) alignment 
Range on Protein: 452-532
Range on HMM: 11-83/85.0
VtRGNSIAINWDVPKTPNGKVVSYLIHLlgNPMSTVDremwGPKIRRIDEPHHKTLYESVSPNTNYTVTVSAITRHKkNGE
| . .|. ..|. ||...|....| ...   .... .     .| ........    .   |.|.|...| |....  .|.
v.tstsltlsWsppkdgggpitgYevey..rekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngag.egp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1250-1302 4e-08 27.0 In-house 230-280 (440) alignment 
Range on Protein: 1250-1302
Range on HMM: 230-280/440.0
EGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDgpRKCPRYWA
||| . ..|| .| ||. |. ||||.. .  ..|..|. .. |  . |  || 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..ktcsiywp
subfamily_hpo-7_pd Subfamily hpo-7 1265-1433 7.4e-08 26.6 In-house 43-209 (263) alignment 
Range on Protein: 1265-1433
Range on HMM: 43-209/263.0
LENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWA---DDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGevPEV
| .||  |...|  .  ...||...  . |  || .|.    |.  .. .. |   .. | .    .|.  |  .   | .|....|.||. . .  || 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd..pel

CRGIIELVDQAynhyknnKNSgcrSPLTVHCSLGTDRSSIFVAMCILVQ----HLRLEKCVDI--CATTRKLRSQRTGL
 | |..... |       .||    .| |||| |  ||. |. . .. |     |.  . |..      ..|||.|.. 
areilnilkva.......rns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkra
V-set Immunoglobulin V-set domain 35-119 8.1e-08 23.1 Pfam-A 13-102 (114) alignment 
Range on Protein: 35-119
Range on HMM: 13-102/114.0
AEIGKNVSLECASE---NE-AVAWKLGNQ------TINKNHTRYKIRTEPLKSNDDGSENNDSqdfiKYKNVLALLDVNIKDSGNYTCTAQTGqN
.. |..|.|.|  .   |. .. |  ...       |....   . .... .|..    .| |    |..  | . ... .||| |||.. .  |
vaeGgsvtLpCfysssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngs....ksdfsLtiqnlrleDsGtYtCavsds.n
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1388-1449 8.3e-08 26.5 In-house 2-63 (69) alignment 
Range on Protein: 1388-1449
Range on HMM: 2-63/69.0
TVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN
 |||| || |.  |.|. . .  .. || |||    . .|  |  ..    .| |.| |...
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_PTPDC1_pd Subfamily PTPDC1 1052-1143 1.1e-07 26.4 In-house 80-162 (182) alignment 
Range on Protein: 1052-1143
Range on HMM: 80-162/182.0
RRQITqYHYLTWKDFMAPEhPHGIIKFIRQINSvySLQRGPILVHCSAGVGRTGTLVALdSLIQQLEeedsVSIYNTVCDLRHQRNFLVQSL
...|. .. ..|||. ..   . |.  .. ...  .||.| . ||| || |||| |.|   |. . .    ..  ...  .|..|   .|. 
eqgiy.vynfgwkDygvas.leriLdivkvvaf..alqegkvavhChaGlGrtGvliac.ylvyakr....ltaekaiklvrskrpksiqtr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1357-1453 1.1e-07 25.7 In-house 242-340 (347) alignment 
Range on Protein: 1357-1453
Range on HMM: 242-340/347.0
VPEVCRGIIELVDQAYNHYKNN--KNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL
 |.  . .. ||   ...  .    | . ..|. | | || |||.  |   |... .   |  |  .  .|.| ||.|..     | .  || . |  |
ypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylkl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1389-1450 1.4e-07 25.8 In-house 2-63 (69) alignment 
Range on Protein: 1389-1450
Range on HMM: 2-63/69.0
VHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY
|||| || |.  |.|. . .  .. || |||    . .|  |  ..    .| |.| |... 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 912-1010 1.7e-07 24.3 In-house 22-88 (169) alignment 
Range on Protein: 912-1010
Range on HMM: 22-88/169.0
SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINAnfvigykerkkficaqgpmestiddfwRMIWEQHLEIIVMLTNLEEYNkakcaKYWPEKV
..|  |  |||     |  .|||||  .     .|||||                           |||||    .||.| . .. |      .|||| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 912-1010 2.3e-07 23.8 In-house 21-87 (169) alignment 
Range on Protein: 912-1010
Range on HMM: 21-87/169.0
SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINAnfvigykerkkficaqgpmestiddfwRMIWEQHLEIIVMLTNLEEYNkakcaKYWPEKV
..|  |  |||     |  .|||||  .     .|||||                           |||||    .||.| . .. |      .|||| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpeke
0048567 (Phosphotyrosine protein) phosphatases II 1056-1110 3.6e-07 24.7 In-house 28-97 (157) alignment 
Range on Protein: 1056-1110
Range on HMM: 28-97/157.0
TQYHYL------TWKDFMAPE---HPHGIIKFIRQINSVY---SLQRGPILVHCSAGV---GRTGTLVAL
 ...|.       . || ..    . . ...||...|...   .|....| |||.||    |||.||...
ynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1338-1454 9e-07 22.9 In-house 213-347 (350) alignment 
Range on Protein: 1338-1454
Range on HMM: 213-347/350.0
DTLKVTQFQYNGWPTV-DGEVPEVCRGIIE----LVDQAY--NHYKNNKNsgcrSPLTVHCSLGTDRSSIFVAMCILVQ-HLRL-------------EKC
| . | |.|.. |. .     ||    ..|    |.|. .  .|..|..     ||. |||| |  |  ..|..  |..  . |              | 
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars....spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaakt

VD-ICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLH
 | |  .  .||.||  .. .  |. |.. |. .|  |.
rDlisiivnelrkqrismvqnldqfifiYeallfyfaLr
subfamily_DSP23_pd Subfamily DSP23 1058-1145 9.6e-07 23.6 In-house 54-134 (148) alignment 
Range on Protein: 1058-1145
Range on HMM: 54-134/148.0
YHYLTWKDFMAPeHPHGIIKFIRQINSVYSlQRGPILVHCSAGVGRTGTLVALDsLIQqleeEDSVSIYNTVCDLRHQRNFLVQSLKQ
.. |  .|.. |  .. . .|.| ..   . .   . |||  | |||||..|   |..    |  ..  ... ..|..|   |....|
lvrlriddyhpp.aleqvvefvrvveeaee.kneavsvhcllgrgrtgtmlacy.lvk....erklaaaeaiaevrrlrpgsvetveq
PTPc_motif_SM00404 1036-1109 1.8e-06 22.9 In-house 31-99 (140) alignment 
Range on Protein: 1036-1109
Range on HMM: 31-99/140.0
TLNVSKNKA-NvgEEEDRRQITQYHyltWKDFMAPEHPH---GIIKFIRQInsvySLQRGPILVHCSAGVGRTGTLVA
 .||....  .  .|. ..|| |.     .|    .  .    ...||...      ..| .|||| ||| |..||..
vinvteevslt..kensgfqilqip...lddnekdklskyldkvldfiena....ekkggkvlVHCqaGvSRSatlii
Ig_2 Immunoglobulin domain 135-233 1.9e-06 19.8 Pfam-A 4-80 (80) alignment 
Range on Protein: 135-233
Range on HMM: 4-80/80.0
LQSTPDRIkrKIKQDVMLYCLIEmypQNETTNrnLKWLKDGSQFEfldtfssisklndTHLN--FTlefTEVYKKENGTYKCTVfDDTGLEITSKEITLF
|...| ..    ...| | | ..   .|.|..  ..| |||....             .. |  |.    .|  ...||| |..   ... ..|. ....
lsapptvv..tegenvtLtCqap...gnptpk..vqwykdgeels.............qsqnalfi...pnvsaedsGtYtCra.snsegskqsnsvevt

V
|
v
V-set_CD47 CD47 immunoglobulin-like domain 22-119 2.1e-06 15.0 Pfam-A 11-109 (130) alignment 
Range on Protein: 22-119
Range on HMM: 11-109/130.0
CAICVQGSVKQEWAEIGKNVSLECASEN----E----AVAWKLGNQTINKNHTRYKIRT-EPLKSNDDgsenndsQDFIKYKNVLAlLDVNIKDSGNYTC
  ....  .. |     . |...|  .|    .     | ||. |. |.....  |. | |   |          ....| .  |  || . . ||||||
aqlvfnkvksveytvCndtvvipCdvdnleyknisevyvkWkfknkdififnktekkstsesfpsakl.......sellkgdasLk.ldfsdalsGnYtC

TAQTGQN
 .   .|
evtelsn
DSPc Dual specificity phosphatase, catalytic domain 1034-1109 2.6e-06 22.3 Pfam-A 20-92 (133) alignment 
Range on Protein: 1034-1109
Range on HMM: 20-92/133.0
ERTLNVSKNKANVgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVySLQRGPILVHCSAGVGRTGTLVA
. ..||.|.. |    ..  .  .|  .  .|.   .    . . .. |...   ... .|||| ||. |..||..
tlvinvtkevpnn..naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 1034-1109 2.6e-06 22.3 In-house 20-92 (133) alignment 
Range on Protein: 1034-1109
Range on HMM: 20-92/133.0
ERTLNVSKNKANVgeEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVySLQRGPILVHCSAGVGRTGTLVA
. ..||.|.. |    ..  .  .|  .  .|.   .    . . .. |...   ... .|||| ||. |..||..
tlvinvtkevpnn..naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1001-1143 4.3e-06 20.4 In-house 148-288 (332) alignment 
Range on Protein: 1001-1143
Range on HMM: 148-288/332.0
K-CAKYWPEKVfDTKQFGDILVKFAQERKTGdYIeRTLNVSknkanVGEEEDRRQITQYHYLTWKDFM-APEHPHGI-----IKFIRQINSvYSLQRGPI
| | |.||||    |.|  . .. ....    .. .|.|..     | |... .|    |.  | |    ||.   .     ...||  .    .  |||
kicrkfwpekr.skkdfpalsiqasddhset.hm.ktfnlt.....vtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskk.tgvcigpi

LVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSL
.. |..|| .     ..| .. .. ||  | . .|.  .. ||   ....
mlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtv
subfamily_Paladin_pd Subfamily Paladin 1056-1115 6e-06 15.4 In-house 202-264 (314) alignment 
Range on Protein: 1056-1115
Range on HMM: 202-264/314.0
TQYHYLTWKDFMAPEHP--HGIIKFIRQINSVYSLQRGPILV-HCSAGVGRTGTLVALDSLIQ
 .|| .   .. ||.      ... .....|..| . ||.||  |  |.||| |  ..  || 
lsyhriplpeqkapleedldqllevlkevpsllskedgpalvFschsGkgrTttamvvavLil
I-set Immunoglobulin I-set domain 136-222 8.4e-06 17.5 Pfam-A 4-81 (90) alignment 
Range on Protein: 136-222
Range on HMM: 4-81/90.0
QSTPDRIKRKIKQDVMLYCLIEMYPQNEttnrnLKWLKDGSQFEFldtfSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGL
. ...... .. ..| | | .|  |. .      .|.||||. .     |.  |.. .. . ||....| ....|.|.|..   .| 
tqklkdvevseGesvelectveGepeps.....vsWakdgselks....sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagk
subfamily_CDC14_pd Subfamily CDC14 1079-1110 8.8e-06 19.8 In-house 252-283 (328) alignment 
Range on Protein: 1079-1110
Range on HMM: 252-283/328.0
IRQINSVYSLQRGPILVHCSAGVGRTGTLVAL
...  ..    .| | ||| ||.||||||.| 
vkkfleiaekaeGaiavhCkaGLGrtGtLiac