Gene Ptp10D in Drosophila melanogaster

Synonym: 10D, CG1817, CT4920, DPTP, DPTP10D, DPTP[[10D]], Dmel\CG1817, PTP10D, Ptp10, R-PTP 10D, dptp, ptp10D, Dmel_CG1817, Ptp10D

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP047_AA protein Get Run
DmelP047_AA_1254-1529 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 1247-1533 9.2e-141 463.0 In-house 2-290 (293) alignment 
Range on Protein: 1247-1533
Range on HMM: 2-290/293.0
EQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQG
....|| ...|.||.. |.||||.|||||.||||.||.|| ...|.|..|| |||.||||||||||.||....|..|||||||||.||.|||||||.|||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTL
||..|.||||||.||..|..|||||...|||..||..|||.|. ||.||||||........ |||. |.......|.| .|..|||.|||.|||. ..||
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

VRFVRAFRDRI--GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
..|||..|..|   |..|||||||||||||.||||.|||.||.|...|||||||||...|.||...||||.|||.||||.|..|. ||.
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_PTPRD_pd Subfamily PTPRD 1250-1530 2.6e-113 374.6 In-house 3-283 (564) alignment 
Range on Protein: 1250-1530
Range on HMM: 3-283/564.0
RPILIKNFAEHYRLMSADSDFRFSEEFEELKHVgRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLH
.|| .....||.. . |.||..|.||......  .  ... |. |.|..|||. ||..||||| .|..|. |||||||||... |.......| |||||.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

STRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLV
.| .|||||.|| ||. |||||.. |||..||..|||... .  ||...|.. .  ..|| ....| | .   ||.|  |.|||| ||| |||. ...|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

RFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
...|  |.    .. ||||||||||||.||||..| .|..|.... |||...| |.||.|  |||||.||| ||. .|  |. 
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0051299 (Phosphotyrosine protein) phosphatases II 1249-1527 2.6e-102 337.4 In-house 2-285 (288) alignment 
Range on Protein: 1249-1527
Range on HMM: 2-285/288.0
NRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL
...| ......... . |..  .. |||||| ..  | ....| ||.|..|||...|||||||| ||...|..||||||||.|..|.|..|.||.|||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

HSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdTVPVFYGDIKVQILNDSHYADWVMTEFMLC------RGSEQRILRHFHFTTWPDFGVPNP
..| .|||||.|| |.| |||||...|.|||||.||||.   .. ||||.| .|.  ...|........        ..| |. .|||.|.|||.|||. 
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

PQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|. |..|.|..|. . . . |.||||||||||.||||.|| .|.|...   ||....|  .|. |  ||||..||. ....||  
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0050432 (Phosphotyrosine protein) phosphatases II 1243-1531 1.7e-100 331.6 In-house 17-302 (308) alignment 
Range on Protein: 1243-1531
Range on HMM: 17-302/308.0
DSVIEQNRPILIKNFAEHYrlMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLqpvddDEGSDYINANYVPGH--NSPRE
.|.   . .. ........  ..|..  ...|||||| .|  . ....| ||.|..|||...|||||||| ||     |||||||||.||.|.  ..||.
tsilvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprk

FIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND--TVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPD
||.|||||..| .|||||.|| |.| |||||...|.|||||.||||..    .. ||...| .|.  ...|.......|.   ..| |...|||.|.|||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

FGVPNPPQTLVRFVRAFRDRIgaEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
.|||. |. |..|... |...  .. ||||||||||||.||||.|| .|.|...   ||.|..|. .|. |  ||||..||. ....||  |. |
hgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0040438 (Phosphotyrosine protein) phosphatases II 1255-1528 3.9e-98 323.9 In-house 3-276 (317) alignment 
Range on Protein: 1255-1528
Range on HMM: 3-276/317.0
KNFAEHYRLMSADSDFRFSEEFEELKHVGRDqPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDD
... ... .. . .  ...||||.| ..  | ....| ||.|..|||...|||||||| ||.|.. |..||||||.||.|.| .|.||.||||| .| .|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRA
||||.|| ... |||||...|.|||||.||||.   .. |||..|..|.  ..|.........   ..||.|...|||.|.|||.|||  |..|..|..|
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

FRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
 |. .  .. |..|||||||||.||||.....|.|...   ||.. .|. .|. |  .|||..||. ....||  |
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0036941 (Phosphotyrosine protein) phosphatases II 1262-1533 1.9e-96 318.1 In-house 5-282 (297) alignment 
Range on Protein: 1262-1533
Range on HMM: 5-282/297.0
RLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLqpvdDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWE
.|.....  ....||||| ..  . ... | ||.|..|||...||||||.| ||    ||||||||||.||.|.. .|.||.|||||..| .|||||.||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

SNSRAIVMLTRCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSH--YADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR
 |.. |||||...|.|||||.||||..   .. |||..|. |. ..  ..|...... .    ..|.|...|||.|.|||.|||. |..|..|....|..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

IGA--EQRPIVVHCSAGVGRSGTFITLDRILQQIN---TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
. .  .. |..||||||||||||||..| .|||..   .   |||. .|  .|. | ..|||..||. ....||  |  |..
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1252-1533 7.4e-96 315.9 In-house 2-285 (318) alignment 
Range on Protein: 1252-1533
Range on HMM: 2-285/318.0
ILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHST
| ......| | . .. .  .|||.|.|... .    . .  |.|. |||..|||.|||.| |||.....||||||||||..|... ...| .|.||  |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

RDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCRG--SEQRILRHFHFTTWPDFGVPNPPQTLVRF
 .||||| || ||. |||||.. |.|..|...|||..  .  ||...|.. .. ...|.|. || . |   .|.|. | .|.|.||| |||. . .|. .
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

VRAFRDRI-GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
||  .     ....|||||||||||| |.||..| .|..|.    ||.|..|  .|..|  |||||.||. |.. ||  |.  . 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
0039614 (Phosphotyrosine protein) phosphatases II 1246-1528 1e-95 315.8 In-house 8-289 (297) alignment 
Range on Protein: 1246-1528
Range on HMM: 8-289/297.0
IEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDqpCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDD-DEGSDYINANYVPGHNS-PREFIV
. .. || .. .. ...|. |.|  .. .|||||. .  |  ...| ||.|..|||...|||||||| ||.|.|. |..||||||.||.|..  .|.||.
llesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

TQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGReKCDQYWPNDTVpvFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPP
|||||..| .|||||.|| ....|||||...|.|| ||.||||...    |||..|  |.  |......... . ...| |...||..| |||.|||. .
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

QTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..| .|... |... .  ...|..|||||||||.||||.....|.|...   ||.. .|  .|. | ..|||..||. ....||  |
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0046845 (Phosphotyrosine protein) phosphatases II 1272-1529 1.9e-95 314.8 In-house 2-275 (284) alignment 
Range on Protein: 1272-1529
Range on HMM: 2-275/284.0
FSEEFEELKHVGRDQ--PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDD-EGSDYINANYVPGH-----NSPREFIVTQGPLHSTRDDFWRMCWESN
. |||||| ..  ..  ....| ||.|. |||...|||||||| ||...|.| |.||||||.||.|.     .....||.||||| .| .|||||.|| |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG--
.| |||||...|.|||||.||||..  .. |||..| .|.  .. |.......| .   ..| |...|||.|.|||.|||  |. |..|.|. |. .   
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSD---YVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
  . ||||||||||||.||||.|| .|.|... .    ||....|. .|. |  ||||..||. ....||  | 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0043336 (Phosphotyrosine protein) phosphatases II 1254-1525 4.8e-94 310.2 In-house 4-274 (278) alignment 
Range on Protein: 1254-1525
Range on HMM: 4-274/278.0
IKNFAEHYRLMSADSDFRFSEEFEELKHVGRdQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRD
.|....... . ...  ....||||| ..    ....| ||.|..|||...|||||||| ||.... |..||||||.||.|.| ||.||.|||||..| .
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPndTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVR
|||||.|| ... |||||...|.||.||.||||    .. |||..|  |.  |..|.... . .   . .| |. .|.|.. |||.||| ....|..|..
dFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
|.|...  .. |..|||||||||.||||.|...|.|...   ||.. .|  .|. | ..|||..||. ....||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0047943 (Phosphotyrosine protein) phosphatases II 1262-1526 2.3e-93 307.9 In-house 4-270 (273) alignment 
Range on Protein: 1262-1526
Range on HMM: 4-270/273.0
RLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLqpvdDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWE
.|.....  .. ||||.|. .  . ....| ||.|. |||...|||||||| ||    .|.|||||||.||.|.|..|.||.||||| .| .|||||.||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

SNSRAIVMLTRCFEKGREKCDQYWPNDTV--PVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRI
 |.| |||||...|.|||||.||||..    .. ||...| .|.  ...|.......| .   .| |. .|||.|.|||.|||  .. |..|... |. .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GA--EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
 |  .. |.||||||||||.||||.|| .|.|...   ||.. .|. .|. |  ||||..||. ....|| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1251-1529 1.1e-92 305.2 In-house 3-280 (288) alignment 
Range on Protein: 1251-1529
Range on HMM: 3-280/288.0
PILIKNFaEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHS
||.|..  ..   .||..   ||||.. |  .....  | . |. | .|||. ||||||. | ||. ... .|.|||||.|. |... ...| ||||| .
pihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPlad

TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFV
| .|||.. .| ..  |||||   |.|..||..|||..  |. ||...|..... .  |.|. ...| .  ... . ......||| |||.  . |. ..
tvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllell

RAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|       |.. ||.|||||||||.||||.|| ........||.|..|.|  .||.|  .|||..||. |...|| . |
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
0045450 (Phosphotyrosine protein) phosphatases II 1250-1528 1.4e-92 306.0 In-house 7-304 (307) alignment 
Range on Protein: 1250-1528
Range on HMM: 7-304/307.0
RPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGR--DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDD-EGSDYINANYV--------PGHNSP
..| ....  ...|. .|.  .. .|||.|..|      ....| ||.|..|||...||||||.| ||...|.. |.||||||.||        .|....
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLC---RGSEQRILRHFHFTTWP
|.||.|||||..| .|||||.|| ....|||||...|.|||||.||||..  .. ||...|  |. .|....... . .      .| |...|||.|.||
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DFGVPNPPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|.|||  ...|..|... |. ...  .. |..|||||||||.||||... .|.|...      ||.. .|  .|. | ..||...||. ....||  |
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 1272-1528 2.3e-91 301.2 In-house 2-262 (263) alignment 
Range on Protein: 1272-1528
Range on HMM: 2-262/263.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
..||||.|.    ....| |. . |. |||..|||||||.| ||.. ...||||||||||. |.|.....|.||||| || .|||||.|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYA-DWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVH
...|.|.||||.|||..   .  .|.|.|.. .  ..  ....... |      |.| ........||| |||. .. .....||.. .   .. |||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|||||||.|||.|.| ||..... . |||| || ..||.|  ||||..||. |....|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1272-1528 2.3e-91 301.2 In-house 2-262 (263) alignment 
Range on Protein: 1272-1528
Range on HMM: 2-262/263.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
..||||.|.    ....| |. . |. |||..|||||||.| ||.. ...||||||||||. |.|.....|.||||| || .|||||.|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYA-DWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVH
...|.|.||||.|||..   .  .|.|.|.. .  ..  ....... |      |.| ........||| |||. .. .....||.. .   .. |||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|||||||.|||.|.| ||..... . |||| || ..||.|  ||||..||. |....|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRG_pd Subfamily PTPRG 1253-1536 7.6e-88 290.1 In-house 2-295 (563) alignment 
Range on Protein: 1253-1536
Range on HMM: 2-295/563.0
LIKNFAEHYRLMSADSDFRFSEEFE--ELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGS-DYINANYVPGHNSPREFIVTQGPLH
 .|.||.|   . ||.| .||||||  . ... .| ...... |.|. ||| .||..||.|| ||.|. . ... |||||||. |..  ..||.|||||.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

STRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCR-----GSE---QRILRHFHFTTWPDFGVPN
.| |||||| || |.  |||.|   |.||.|||.|||.|. .. || ..|.. .  . |   . ....       ...   ..  |..|.|.||| |||.
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkde.setygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

PPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVG
 .   . ||.       ||  ||||||||||||.||.| || .|.||.. . |..||..  .| .|  .|||| ||| .|. || .. .||. . 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1249-1531 9.9e-84 276.1 In-house 2-286 (319) alignment 
Range on Protein: 1249-1531
Range on HMM: 2-286/319.0
NRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDqPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL
...| .....|... . . ..  . .||..||. . |   . |. . |..|||..|||.||..| .|...|. ||||||||... |..  ..|| ||.||
dteievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPl

HSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ---RILRHFHFTTWPDFGVPNPPQT
. | .||||| || .|  .||||.  ||.. |. .|||. . .. || . |..... . .|... ...| . |..   | . ||..| ||| .||.  ..
entiedfWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LVRFVRAFRDRIGA-EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
|. ...  |      ...|||||||||||| ||||.|| .|....    .|.| .|  .|  |  |||...||. |.. ||...|  
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1260-1529 2.2e-83 274.6 In-house 5-277 (281) alignment 
Range on Protein: 1260-1529
Range on HMM: 5-277/281.0
HYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMC
| . .|....  | ||.|.|...|.|.. | .  . |. |||..||  ||..| |..| .... .||||||.||| ....|.|.||||. .. ..||.| 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML-CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG
|| . .||||.||  |.|. || .|||.|.  . |||..|. .. .. | ..  .|.|  ...|.| ......|.||| |||. .. |. | .. .    
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklte

A-EQRPIVVHCSAGVGRSGTFITLDRILQQINT-SDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
  .. |.|.||||||||.||.|.|||.......    .|.  .|  .|||| .||||  ||  ... .| .|.
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0040439 (Phosphotyrosine protein) phosphatases II 1287-1526 2.7e-83 274.7 In-house 2-244 (249) alignment 
Range on Protein: 1287-1526
Range on HMM: 2-244/249.0
PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP
....| ||.|..|||...||||||||.||..... ..||||||.|..| ...|.||.|||||..| .|||||.|| ....|||||...|.|||||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NdTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLD
.   .. |||..|. |.  ...|.......|     .| |  .|...| |||.|||  ...|..|..| |. . .  .. |..|||||||||.||||...
l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
 .|.|...   ||.. .|  .|. | ..||...||. ....|| 
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 1249-1534 5.2e-83 273.6 In-house 11-302 (330) alignment 
Range on Protein: 1249-1534
Range on HMM: 11-302/330.0
NRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL
  |. .... |  |  |||   .| |||. |     .  .  |.   |. |||. ||||||.||  |....  | |||||| .. |..   .|| .|||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

HSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLC------RGSEQRILRHFHFTTWPDFGVPNP
. | .||||| || .| .|||||   |. .||| ||||.. . | ||.|.|.. ..    |. . .|..       |  ..|..| ||||.|||.|||  
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

PQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV-LEGKENI
|. ....... .     .  ||||||||||||.||||.|| .|.....   ||.|..|  .|. |  ||||..||  |.. ||   | |  ..
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel
0042113 (Phosphotyrosine protein) phosphatases II 1288-1527 8.6e-83 272.7 In-house 1-242 (245) alignment 
Range on Protein: 1288-1527
Range on HMM: 1-242/245.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPN
...| ||.|..|||...||||||.|.||.|.. |..||||||.||.|.. .. ||.|||||..| .|||||.|| ....|||||...|.||.||.||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

dTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG-AEQRPIVVHCSAGVGRSGTFITLDRI
   .. |||..|. |.  |..|........   . .|.|  .|.|.. |||.|||. ...|..|... |. .   .. |..|||||||||.||||.....
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|.|...   |... .|. .|. | ..|||..||. ....||  
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 1266-1530 3.8e-82 271.1 In-house 3-274 (278) alignment 
Range on Protein: 1266-1530
Range on HMM: 3-274/278.0
ADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKlqpvdddegsDYINANYVPGHnsPREFIVTQGPLHSTRDDFWRMCWESNSR
|... ... |||.| . |  . .|.| ...|..|||...|||||||| |          |||||.|..|.  |..||.||||| || .|||||.|| ...
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

AIVMLTRCFEKGREKCDQYWPNdTVPVFYGDIKVQILNDSHYADWVMTEFMLC------RGSEQRILRHFHFTTWPDFGVPNPP--QTLVRFVRAFRDRI
.|||||...|.|||||.||||.   .. |||..| .|. ... |.... ....       . |.| ..|.|...|||.|||. |  . . ....  |...
vivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefireal

GA-------------EQRPIVVHCSAGVGRSGTFITLDRILQQIntSDYVDIFGIVYAMRKERVW-MVQTEQQYICIHQCLLAVLEG
 .             .. |..|||||||||.||.. .. .|...   . ||.. .|  .|. |   .||...||. ....|| .|. 
kllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
Y_phosphatase Protein-tyrosine phosphatase 1296-1525 4.1e-81 267.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 1296-1525
Range on HMM: 1-234/235.0
NRPKNRFTNILPYDHSRFKLqpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-NDTVPVFY
|. |||...|||||..| ||   .... ||||||||| |......||.||||| || .|||||.|. ....|||||.. |||||||.|||| ..  .. |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIKVQIL-NDS-HYADWVMTEFMLCRGSEQ---RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN
|||||..  . . . ........ |    |.   |.....|.|.||| |||. |. |....|... .  |.. |.||||||||||.|||..|| .|.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
. . ||.. ||  .||.|  |||...||| .....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1296-1525 4.1e-81 267.2 In-house 1-234 (235) alignment 
Range on Protein: 1296-1525
Range on HMM: 1-234/235.0
NRPKNRFTNILPYDHSRFKLqpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-NDTVPVFY
|. |||...|||||..| ||   .... ||||||||| |......||.||||| || .|||||.|. ....|||||.. |||||||.|||| ..  .. |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIKVQIL-NDS-HYADWVMTEFMLCRGSEQ---RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN
|||||..  . . . ........ |    |.   |.....|.|.||| |||. |. |....|... .  |.. |.||||||||||.|||..|| .|.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
. . ||.. ||  .||.|  |||...||| .....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1253-1530 6.8e-81 266.8 In-house 10-292 (298) alignment 
Range on Protein: 1253-1530
Range on HMM: 10-292/298.0
LIKNFAEHYRLMSADSDFRFSEEFEELKHVGR---DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLH
|.. . .    . . .  ....||..|..|     ..  . |  | |. |||...|...|.||  |. .|.|| |||||| .. ...    ||.||.||.
lkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt

STRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDtVPVFYGDIKVQILNDSHYADWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLV
.|  ||||| .| .. .|||||   |... |. .|||..     ||.|.|..|.. ..|| ....... . .  ..| .|..|||.||| |||.  ....
etvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvl

RFVRAFRD-RIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
 ..|  |  .  | ..|..|.|||||||||||| .| .|......  ||.| .| ..||.|. .||||.||. |..  | .|. 
dllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_PTPRK_pd Subfamily PTPRK 1258-1534 1.5e-79 262.1 In-house 10-284 (314) alignment 
Range on Protein: 1258-1534
Range on HMM: 10-284/314.0
AEHYRLMSADSDFRFSEEFEELKHVgrdqpCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWR
 ..  |. .   . | ||.| |           |    || |||...||.||.|| .|...|.|  ||||||... ... |..||||||||..|  ||||
lqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWr

MCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPvfYGDIKVQILNDSHYADWVMTEFMLCR----GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF
. .. |. .|||||   |.|| || .|||.||    ||||||.... .  |. |.  | ...     .|.|..|.|.|..|||..||.  ..|...||  
lvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

RDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENI
      |. .|||||||| ||.||||..| .|. |.. . ||.| .| ..|...| ||.||.||. |.. .|  .| |.  |
kksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetai
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1251-1535 4.4e-77 254.2 In-house 3-291 (305) alignment 
Range on Protein: 1251-1535
Range on HMM: 3-291/305.0
PILIKNFAEHYRLMSADSDFRFSEEFEELKHVgrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHS
.| ....|.. . ....||  . .....| .   ....       |. |||...| ..|..|..|.. .... ||||||.|| |...  ..||.||||..
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP-VFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTL
| .||||. .|   . |||||.  | |..|| ||||. .   . .|...|.. . ....|... .. ..     .|.| . ....|.||| |||. . .|
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

VRFVRAFRDRIGAEQR-PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE-NIV
.....  . .   ..  |..|||||||||.|.||..|  |..... . ||.|... ..|..|. |||| .||  .|. |   ..  . .|.
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsii
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1292-1532 7.2e-77 253.0 In-house 5-246 (250) alignment 
Range on Protein: 1292-1532
Range on HMM: 5-246/250.0
DLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREkCDQYWPNDTvP
  | |. |||...|...|.||  |.... |. |||||| .. |..  . ||.|||||..|  ||||| .| .| .|||||   |.... . |||| .. .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.a

VFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ--RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA-EQRPIVVHCSAGVGRSGTFITLDRILQQI
  |||..|..|.. ..||.......| . ...  ||.|..||..||| |||.  .. . ...  .      ...|..|.|||||||||.||..| .|...
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

NTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
...  ||.| .. ..||.|. .|....||. ... .|  |.  |
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_PTPN9_pd Subfamily PTPN9 1273-1526 1.2e-76 252.5 In-house 19-288 (297) alignment 
Range on Protein: 1273-1526
Range on HMM: 19-288/297.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTR
|.|..|...       . . |..|  |||.|..| ||..| .|. ||.|| |||||||.| |.. .. || |||||. | .||||| ||.. . ||| ||
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

CFEKGREKCDQYWP-NDTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR-------IGA---
. |.|| || |||| ..     .||..|. ... .. |.... . .   . .|.| . || |..|||.|||.  ..|. .... |..       .|.   
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewk

---EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
   .. |||||||||.||.|||||||  |..... . ||..  |  .|. | ...||..||   ....| 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN12_pd Subfamily PTPN12 1271-1529 2.1e-76 251.6 In-house 9-278 (290) alignment 
Range on Protein: 1271-1529
Range on HMM: 9-278/290.0
RFSEEFEELKHVGR----DQ--PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNS
.|..||..||.. .    ..  . . .. . |. |||. .|||||.|| .|.  ...|||||||||.. | ... |.| .||||  | |||||| || | 
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

RAIVMLTRCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYA-DWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQR
. .||. | .| |. ||..|||.    .. .|...|.  .. .   |...  . . . .|.|... ||.| ||| |||. ...|.......|..  .|. 
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqeseda

PIVVHCSAGVGRSGTFITLDRILQQINTS---DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|.|||||||||| || |..| . .....    . .|.| .|  .||.|. .|||..||  ...... ...
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0037934 (Phosphotyrosine protein) phosphatases II 1288-1525 3.1e-76 251.4 In-house 2-239 (243) alignment 
Range on Protein: 1288-1525
Range on HMM: 2-239/243.0
CTFADLPCNRPKNRFTNILPYDHSRFKLqpvdddEGSDYINANYVPGHnsPReFIVTQGPLHSTRDD----FWRMCWESNSRAIVMLTRCFEKGREKCDQ
...| ||.|..|||...|||||||| ||      |||||||||....   || .|.||||| .| .|    ||||.|| ....|||||...|.|||||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPnDTVpvFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA--------EQRPIVVHCSAGV
||| ..|   |||..|..|. .|..|.......|..   . ..|  .|.|.. |||.|||. |. |..|... |. | .        ...|..|||||||
ywp.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRSGTFITLDRILQQIntsDyVDIFGIVYAMRKERVW-MVQTEQQYICIHQCLL
||.||.|... .|...   . ||.. .|  .|. |   .|||..||. ....||
gRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Ptp69D_pd Subfamily Ptp69D 1251-1528 3.8e-76 251.2 In-house 3-286 (307) alignment 
Range on Protein: 1251-1528
Range on HMM: 3-286/307.0
PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHS
.| |.. .| ..    |.|| . .|.|.|..   |. .....   |  |||. .| ..|. | ||...  .| ||||||... |..  ..||. |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDtVPVFYGDIKVQILNDSHYADWVMTEFMLCRGS-------EQRILRHFHFTTWPDFGVPNPP
| .||||| .| ..  ||||.   || |.||..|||..   | |||| |.. . ..  |... |. . .         ..| .  .|.|.|.|. ||. .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

QTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..|.....  |.    .. ||||||||||||||.|..|| .|||... | |||| .|  .|..|  .||  .||. ... ||   
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPN6_pd Subfamily PTPN6 1270-1532 5.7e-75 247.2 In-house 26-301 (306) alignment 
Range on Protein: 1270-1532
Range on HMM: 26-301/306.0
FRFSEEFEELKHVGRDQPC--TFADLPCNRPKNRFTNILPYDHSRFKLQpVDDDEGSDYINANYVP--GHNSPREFIVTQGPLHSTRDDFWRMCWESNSR
  |.||||||..    .    . .. | |. |||. ||||.||.| .|.  ..  |||||||||.    ..| ...| ||| |..|  ||||| |. |||
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

AIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLC---RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG----
 |||.|.  |.|.||| .|||. .    ||.|.|. ..... ||... |....   ...|.| ....||..||| |||. |.... |..  . .      
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
||..|||||||||.|| |||| .| .|..|... .   .||  .|  .|. |  .|||||||  ... . . .| |.
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1252-1535 5.3e-73 241.1 In-house 11-299 (319) alignment 
Range on Protein: 1252-1535
Range on HMM: 11-299/319.0
ILIKNFAEHYRLMSADSDF-----RFSEEFEELKHVGRDQ-PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQ
. ...|  .|. .|  |||     ..  ||  . ..| .    |||.|. |. |||..|||..|... ||....  |.|||||| .| |. ..  .| .|
vavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaq

GPLHSTRDDFWRMCWESNSRAIVMLTrcfekgREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNP
|||  | .||||| ||.|. .||.||      ..|| ||||...| . ..  ||..      |..|. .. | .     ..| .. |||  ||| |||. 
GPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy

PQTLVRFVRAFRDRIG--AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENIV
|  |.|.|.  |       ....|||||||||||.|..|.|| .|....  . ||.. .|  .|..|  .||   ||  |.  ||   | |. ...
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1272-1530 2e-72 238.9 In-house 20-278 (515) alignment 
Range on Protein: 1272-1530
Range on HMM: 20-278/515.0
FSEEFEELKHVgRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
||||| .|       | | |.   | .|||. |||||| .| ||. ..|.  |||.|| |.|. .. . .| .|||.... |||||. .. |  .|.|.|
fseefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

RCFEKGREKCDQYWPN-DTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSA
.  |  . || .|||.  .  | .| |||...  .  .. .  .. . .|.. | .  |||| ||| |||.  ..|...... .   |  . |...||||
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsa

GVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
|||| | .|..| .. ...|.. ||.| .|  .|..|. .|||..||  |.. .|  |  
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1288-1536 2.9e-71 235.3 In-house 17-264 (284) alignment 
Range on Protein: 1288-1536
Range on HMM: 17-264/284.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTrcfekgREKCDQYWPN
 |||.|. |. |||...||..|... ||....  |.|||||| .. |. ..  .| |||||  | .||||| ||.|. .||.||      ..|| ||||.
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

DTVpVFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRI--GAEQRPIVVHCSAGVGRSGTFITLD
..| . ..  ||..   .  ...|. .. | .     ..| .| |||  ||| |||. |  |.|.|.  |       ....|||||||||||.|..|.||
kiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENIVG
 .|....  . ||.. .|  .|..|  .||   ||  |.  ||   | |. ... 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdval
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1271-1531 3.4e-71 234.6 In-house 20-280 (315) alignment 
Range on Protein: 1271-1531
Range on HMM: 20-280/315.0
RFSEEFEELKHVGrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 ||||| .|       . . |  . | .|||. ||||.|..| ||. .||.  |||||| |... .. . .| .||||... |||||| ....  .|||.
lfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TRCFEKGREKCDQYWPN-DTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCS
|   |  . || ||||. ..  | .| |||..|. .  .| |. .... .. |.| .  |.|| ||| ||..   .|...... .   | .. ...||||
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcs

AGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
|||||.| .|..| ...||. .. ||.| .|  .|..|. .||||..|  |.. .|  |  .
aGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
subfamily_PTPN3_pd Subfamily PTPN3 1275-1529 9.1e-70 229.8 In-house 20-276 (280) alignment 
Range on Protein: 1275-1529
Range on HMM: 20-276/280.0
EFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvdDDEGsDYINANYV----PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
.||.|    ..  .. | .| | .|||. .|||||. | ||.   . |  ||||||||    |...    .|.|||||..|  |||.| || .|. ||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHC
|   |.|| || ||||. .  . ||...|.. ....   .|. |..|.. .  |.| . .. .. ||| |||. .. ...||.  |.   ....|.||||
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|||.||.| .|.|.  |. |.... | .  ||  ||  |  .|||..||  . ...|.| |
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPN1_pd Subfamily PTPN1 1270-1537 2e-69 228.5 In-house 6-277 (290) alignment 
Range on Protein: 1270-1537
Range on HMM: 6-277/290.0
FRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDdegsDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM
 ...| ......  .| |.. |.|| ||..||. .. |||||| ||.  |     |||||. |  ..  |..|.||||| .| | ||.| || .|.|.||
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTRCFEKGREKCDQYWPNDT--VPVFYG--DIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR--IGAEQ
| .. ||.. || ||||..     . .    .||....  ..  ...  . |      | | . |||.|||||||||. |.....|.   |.   .  ..
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdv

RPIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIVYAMRKERVWMVQTEQQyicIHQCLLAVLEGKENIVGP
 | |.|||||.||||||. .| .| .|. .|    |||   . ..|| |. ..|| .|   ..   ||.|||   | |.
GpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadq...lrfsylaileGakvikgd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1270-1527 2e-69 228.9 In-house 24-278 (315) alignment 
Range on Protein: 1270-1527
Range on HMM: 24-278/315.0
FRFSEEFEELKhVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM
  | ...| .   |. .|   |    |. |||. ||..||.|| .|  .. |..|||.|||...|.| .| .| .|||. .. .||||. .| .   |||
ngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivm

LTRCFEKGREKCDQYWPNDtvPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCS
||   |. ..|...|||..   | || | |   .. .. .. .  .    |.. | .  .|.|.||| |||.   .|. ..|  .    ..  .||||||
ltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcs

AGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|||||.||||||| .|.|... . .|.. ..  .|. |. |||. .||  |.. ||  
aGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1254-1529 2.5e-68 225.1 In-house 4-284 (290) alignment 
Range on Protein: 1254-1529
Range on HMM: 4-284/290.0
IKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEG--SDYINANYVPGHNSPREFIVTQGPLHST
...|.|.     |  . .| ..|. |.   ...  | .  . |...|||.||..||  |  |.|. ...    .|||| |. |..  ...|.||||...|
vdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt

RDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVfYGDIKVQILNDSHYADWVMTEFMLCRGSE---QRILRHFHFTTWPDFG-VPNPPQTLV
  |||.. |. .. .|||||   |.|..|| ||||.  .   || .....||.... . . ... .   ..   .... ....|.|.. | |.||   |.
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

RFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
 . .  . .    ...||||||..||||..|....  ... .|   .|.| ... .|  .  .|||.|||  |.| .|  |.
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1248-1532 9.1e-68 223.5 In-house 6-288 (297) alignment 
Range on Protein: 1248-1532
Range on HMM: 6-288/297.0
QNRPILIKNFAEHYRlMSADSDFrFSEEFEELkHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSprEFIVTQGP
. ||| . .||   .  . ..|. |||||  |      || | |.   | .|.|..|||||| || ||. |.||  |||.|| .|.| .   ..| || |
errpiplsdfatlvq.knrhtdv.fseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmP

LHSTRDDFWRMCWESNSRAIVMLTRCfEKGREKCDQYWPNDTVPVfYGDIKVQILNDSHYADWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPN--PP
 ..| .|||.| .. .  .||||.   ... .|| .||....|   .||. |..|  |.    .  |. . .|.   .|... ..|. |||  |..    
mkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

QTLVRFVRAFRDRIGAEQR-PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
..|. ..   |.  . ..  |..|||.||||| | ..|.| .. ...  . |||||.|  .|.||. .|||..||  ... .| .|  ..
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1294-1526 2.3e-66 218.6 In-house 18-262 (270) alignment 
Range on Protein: 1294-1526
Range on HMM: 18-262/270.0
PCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPG-HNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND---T
  ..  ||...|||  ..| .|.....|. . |||||||.| .......| ..||| .|  .|||| ||....||||.|   ||||.||..|||..   .
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

VPVFYGDIKVQILNDSHYADWVMTEFMLC-RGSEQRILrHFHFTTWPDFGVPNPPQ------TLVRFVRAFRDRIGAE-Q-RPIVVHCSAGVGRSGTFIT
| . .|.|||  |....   ...|.  |  .|.|.|.. ||...|||| |||. ..       |.. .|| |       .  |..|||||||||.||.|.
vkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

LDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
|| ... ....  ||.  |. ..||.|. .||. .||  ... .. 
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1291-1525 7.4e-66 217.0 In-house 23-265 (274) alignment 
Range on Protein: 1291-1525
Range on HMM: 23-265/274.0
ADLPCNRPKNRFTNILPYDHSRFKLQP-VDDDEGSDYINANYVPGHNS-PREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND
 |.. .  |||...||| ..||  |..   .|| |.||||||. | .   . .. ||||| .| .||||| .. ... |||||.  |. ..|| .|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

TV---PVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR---IGAEQRPIVVHCSAGVGRSGTFITLD
.       |||..... .  .  |. .....|   ...| . |. .| |||  .|. ..||...|.  ..      |.  |.|||||||.|| | ||. .
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
  ..|.. .  ||...||  .| .|  ||||..||  ||. | 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_PTPN13_pd Subfamily PTPN13 1273-1529 7.8e-66 217.1 In-house 14-270 (273) alignment 
Range on Protein: 1273-1529
Range on HMM: 14-270/273.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvddDEGSdYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
.|||.||...   . |. .    |. |||. |.||||..| ||.    |||. ||||...  |  .   |.|..||||  | .|||.| || ... |.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TRCFEKGREKCDQYWPNDTV-PVF-YGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRdRIGAEQRPIVV
|   |||. ||..|||. .  ..  .. ..|. |.  .. ..|. ....   . .| | . |..|..||| |||. .. |..||.  | |.  .. ||||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr.rlqtdagPivv

HCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|||||.|||||.||.| .|. |.    .|.  ||  .|. |  .|||..||| ... .| ||.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1254-1532 1.9e-65 215.7 In-house 4-282 (287) alignment 
Range on Protein: 1254-1532
Range on HMM: 4-282/287.0
IKNFAEHYRLMSADSDFRFSEEFEELKHVGR-DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvddDEGSDYINANYVPGHNSPREFIVTQGPLHSTR
...|.|  .   | ..  |.. |  |..|.. ..  | .  . |..|||.|.||..|  |  |.    .|  ||||| .. |... ..||....|. .| 
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnta

DDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLCRG---SEQRILRHFHFTTWPDFG-VPNPPQTLVR
 .||.. .. |  |||||..  |. .|.| ||||...  | .|. ....||. ..|.... .. . .    .... .. ...|.|.. | |..|   |. 
rnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

FVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
. . .. .    . .||||||..||||..|.  .  ... .|   .|.| ..  .|  .  .||| .||. | . .|. |.  |
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1252-1528 4e-65 215.1 In-house 5-288 (325) alignment 
Range on Protein: 1252-1528
Range on HMM: 5-288/325.0
ILIKNFAEHYRLMSADSDFRFSEEFEELKHVGrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHST
| . |. ||     |. .  |. ||. |  ..  .  . | .| |. |||| |....|.||  |.  .||  ||||||.|.  .     |. .| || .|
iavvnlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat

RDDFWRMC--WEsnsRAIVMLTRCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTL
 .|.||.   |.    ..|...  ...| ..| .|||..    . .| ..|..    ...|.|.  . .   .. | | .. |.. .|.|.||.. | ||
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatl

VR---FVRAFRDRIGA---EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
.     | |  .|. |      ||.|||||||||.|.||.|  .|... .   ||||| |  .||.|  ||.|  ||| |...|  ..
isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPN23_pd Subfamily PTPN23 1273-1530 4.5e-61 201.2 In-house 22-279 (288) alignment 
Range on Protein: 1273-1530
Range on HMM: 22-279/288.0
SEEFEELKHVGRDQPCTFADlpCNRPKNRFTNILPYDHSRFKLQpvddDEGSDYINANYVPGHN--SPrEFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 |  .. ..  |.. .. |   ..  |||...||||||.| ||.    ..  ||||| .| .    .| .||.||.||.||  |||.| .|  |. ||||
keleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVml

TRCFEKGREKCDQYWPNDT-VPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRD----RIGAEQRP
.   |.|..|.|.|||.|.  .| .||..| . .  .   .|  .. |   . .. . ..| ..|.||..|||. |.||..|. . ..    .    . |
lskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktP

IVVHCSAGVGRSGTFITLDRILQQINTSDY-VDIFGIVYAMRKERVWMVQTEQQYiciHQCLLAVLEG
.||||||||||.|.|  .  ....... .  .||  .|  .|..| .|||...|.   .... |||| 
lvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql...kfsyeavlea
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1296-1525 1.3e-59 196.4 In-house 3-236 (237) alignment 
Range on Protein: 1296-1525
Range on HMM: 3-236/237.0
NRPKNRFTNILPYDHSRFKLQPVDDDegSDYINANYVPGHN-SPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFY
|. |||. ||  |||||  |.    .  ||||||.|. | . .|...| .|||| |. ||||.| |. .   |||||   |. ..|| .|||.   |  |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDIKVQILNDSHYADWVMTEFMLCRGS---EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLDRILQQIN
| . | .  . ...|. .  ..| .     | |..  ..||.||| |||.   .|.|| .   .|     |  | ..||||||||.| |. .| .|.| .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
    |||.  ||.. ..| ...||..||. ||| .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1295-1527 9.3e-58 190.2 In-house 6-236 (239) alignment 
Range on Protein: 1295-1527
Range on HMM: 6-236/239.0
CNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGH-NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpvF
 |. |||..||. |||||  |. . .|  ||||||.|.  .  ||. .| ||| .  .  ||||| |.     |||||   |  ..|| ||||. |    
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..k

YGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS
| ...| . .   .||...  |.. .   .|.| . ..||| ||| |||.   ... . |          || |.||||||||.|.|. .| .|.| .  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DYVDIFGIVYAMRKERVWMVQTEQQYICIHqclLAV
  ||||  | |.|..|  |||| .||. ||   |||
ktvdifnyvkairedrphmvqtseqyvfih...lav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1295-1525 1.2e-57 189.8 In-house 7-238 (239) alignment 
Range on Protein: 1295-1525
Range on HMM: 7-238/239.0
CNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGH-NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpvF
 |. |||..||. |||||  |. . .|  ||||||.|.  .  ||. .| ||| .  .  ||||| |.     |||||   |  ..|| ||||. |    
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..k

YGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS
| ...| . .   .||...  |.. .   .|.| . ..||| ||| |||.   ... . |          || |.||||||||.|.|. .| .|.| .  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
  ||||  | |.|..|  |||| .||. || ..|
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_CG7180_pd Subfamily CG7180 1287-1525 2.4e-57 188.8 In-house 33-287 (296) alignment 
Range on Protein: 1287-1525
Range on HMM: 33-287/296.0
PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGReKCDQYWP
 |  .    || |||  ...|||. |  |. .| .| |||||| || ..  ..|.|||..| ..| |.|||. .. .. |.|.||. |.  . .. .|||
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

NDTvPVFYGDIKVQILNDSHYADWVMTEFMLCRG------------SEQRILRHFHFTTWPD-FGVPNPPQTLV---RFVRAFRDRI--GAEQRPIVVHC
|..    ||.| |.|..  .||. .. .| | .              |.||...|..|.|.    ||   ..|.   | || .|...    |. |.||..
nks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
| |..||| ....|  |....  . ||.|. |  .|..|  .|.. ..|  | . ||
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1275-1525 7.8e-56 184.0 In-house 11-263 (283) alignment 
Range on Protein: 1275-1525
Range on HMM: 11-263/283.0
EFEELKHVG-RDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDdegsDYINANYVP---GHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 .| ||...  |.... |    |..|||. .|.|.|  | .|..       ||||| ..|    ..  ...|..|.||. |. |||.| .. .  |||||
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TRCFEKGREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLCRG---SEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVH
|.  |  |.|| ||||..   . ||.  | . ..     ... |..|       .. .| |. .  | ..|   .  .||.| .    .   .. |||||
tklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvh

CSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
||.|.||...||..   .... |.  ||.| .|  ||..|. .||| .||  .|.  |
CstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1256-1528 1.4e-55 183.6 In-house 6-279 (439) alignment 
Range on Protein: 1256-1528
Range on HMM: 6-279/439.0
NFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCT--FADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRD
.| ||   .  . .  |.|.||... .  |  |   .|    ...|||. .. ..||.|  || .     | ||||||. |.  .. .| |||| . | |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMCWESNSRAIVMLTRCFEKGRekcdqYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLC----RGSEQRILRHFHFTTWPDFGVPNPPQTLVRF
||||. .| ..  |||||  .|  .     ||| |.  |.|||| |..  .    ..|.  | .     ..  .| . .||...|||  ||     .. |
dfwrlviekktvtivmltnlvesyk.....ywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

VRAFRDRIG-AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
.||        |  |.||||||||||.|| |.||  |.|... . ||| |||  .||.|  |||.  ||. |....|  .
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0051429 (Phosphotyrosine protein) phosphatases II 1323-1529 5.4e-55 182.2 In-house 3-226 (272) alignment 
Range on Protein: 1323-1529
Range on HMM: 3-226/272.0
GSDYINANYVPGHNS---PREFIVTQGPLHSTRDDFWRMcWESNSRAIVMLTRCFEKGREKCDQYWP-----------NDTVPVFYGDIKVQILNDSHYA
 |.||||..|.| ..   |. .. ..|||. | .||||. .| . ..||.|....|.||.|||.|||           ... ...||.. | .|  ... 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DWVMTEFMLC---RGSEQRILRHFHFTTWPDFGVPNPPqtLVRFVRAFRDrigaeQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVD--------IF
|....|..|      .| | ..|.|.| |||.|||  .  |........|     ..|..||||||..|.||.. |...|.... .. ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

GIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
..|  .|. | ..||||.||......||..|.
eaveelraqrpgavqteeqylflyeallellr
subfamily_PTPN14_pd Subfamily PTPN14 1273-1528 3.7e-54 178.8 In-house 26-296 (300) alignment 
Range on Protein: 1273-1528
Range on HMM: 26-296/300.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDeGSDYINANYVPG--HNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
  |.|....   |  .. | || | .|||| ..|||...| .|.|  ..  ..||||  .      . |..||.||||. |  |||.| ||.. . ||||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TRCFEKGREKCDQYWPND---TVPVFYGDIKVQ--ILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF---RDRIGAEQ-
|.  |.|.||. .|.|..      | .|  ||.    .||.       ..     .|.| . |. .| ||| |||. ... . ... .   | .   |. 
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

-----RPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
      |..|||||||||.|  |. | ... ... . .||  ..  .|. |  .|||  ||  ... |.  |
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1271-1529 4.1e-54 178.5 In-house 21-237 (392) alignment 
Range on Protein: 1271-1529
Range on HMM: 21-237/392.0
RFSEEFEELKHVGrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 |.||| .|       | | |  . | .|||. |||||| .| ||. .||   |||.|| |.|. .. . .| .|||  .. |||||| .. |  .|.|.
lffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TRCFEKGrekcdqywpndtvpvfygdikvqilndshyadwvmtefmlcRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSA
|.  |                                           .| ..|    |||| ||| .||.   .|..|..  .   |   .|...||||
tklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsa

GVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
||||.|  |..| .. . ...  ||.| .|  .|..| .||||..||  |. ..|  | 
gvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1273-1524 4.8e-54 178.1 In-house 13-273 (287) alignment 
Range on Protein: 1273-1524
Range on HMM: 13-273/287.0
SEEFEELKHVGRDQPCTF--ADLPCNRPKNRFTNILPYDHSRFKLQpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 .|.. ||.  .  . ||  |.   .  |||....||.|..|  |   . . ||||||||||....   .||..|||. .|  ||||. .| .| .....
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

TRCFEKGREKCDQYWPNDTVPVFYGDIKVQILN-DSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF-----RDRIGAEQR
||  |..| || .|||.  ||.  |   | .|. |    .. .  . |    . | |... ... .||| ...     |.|||          | ..|  
treveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCL
|.|||...|.||||.....  .... .    ||.  .|  .|. |  .||.  |.  . . |
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
0041856 (Phosphotyrosine protein) phosphatases II 1296-1533 3.4e-51 168.7 In-house 1-176 (182) alignment 
Range on Protein: 1296-1533
Range on HMM: 1-176/182.0
NRPKNRFTNILPYDHSRfklqpvdddeGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTrcfekgrekCDQYWPndtvpvfyg
|..|||...||||||||          ..||||||.. |   ...||.||||| ||  ||.|| .| . ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dikvqilndshyadwvmtefmlcrGSEQRILRHFHFTTWPDFGVPNpPQTLVRFVRAFRDrigaEQRPIVVHCSAGVGRSGTFITLDRILQQintsdYVD
                          ..|   ..... |||.|||. ...|..|... ..    |..|..|||||||||.||.. .. ....      |.
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
.. .|  .|. |  ||.|..||. ....|| .|..|..
leeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1268-1529 7.7e-50 164.3 In-house 14-294 (301) alignment 
Range on Protein: 1268-1529
Range on HMM: 14-294/301.0
SDFrFSEEFEELKHvGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVD--DDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSR
|.  |.|...|||. |.|..||      |.. ||| || .||. |. |.|    |    .||||.|. | .. ..||..|||...|  ||||. |.    
snk.feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLTRCFEKGREKCDQYWPN-DTVPVFYGDIKVQILNDSHYADWVMTEFM--LCRGSE-QRIL--------------RHFHFTTWPDFGVPNPPQTLV
.|||.|   |. ..|| ||||| ..    .| ..|.. |.  | |.|. ..   .  ||. ..|                 .. | ||. ||   |.| .
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

RFVRAF-RDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
. .      .   .  |.|||||..|.|||......  | |      ||.|... |.|. .  .|.| .||. |.. .   |.
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1272-1526 4.4e-49 161.6 In-house 13-267 (281) alignment 
Range on Protein: 1272-1526
Range on HMM: 13-267/281.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQP-VDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
| .|| .|      . ||  . | |  |||..||   | || .|.  . . . .||| |||.      | .|.|||| . || ||||| |. |. |||||
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TRCFEKGREKCDQYWPNDTVPV-FYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRigaeQRPIVVHCS
 .  |  |||| .|.| ..  .  .  . |.  . .     | | . |    | |.. |. .  |||. ||.  . ... .|  | |      | |.|||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcs

AGVGRSGTFITLDRILQQINTS-DYVDIFGIVYAMRK-ERVWMVQTEQQYICIHQCLLA
||||||||.....  || | .     ||  ||  .|   |   ||| |||. | . || 
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_PTPRN_pd Subfamily PTPRN 1271-1523 1e-48 160.6 In-house 30-287 (297) alignment 
Range on Protein: 1271-1523
Range on HMM: 30-287/297.0
RFSEEFEELKHVGRDQPCT-FADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNsPRE--FIVTQGPLHSTRDDFWRMCWESNSRAI
|...|.| |..   .. ..  |. . |  ||| ...||||||| ||.   ..| ||||||  .  |. ||.  .| ||||| ||  |||.| ||. .  |
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd.prapayiatqgplastvadfwqmvweqGvvvi

VMLTRCFEKGREKCDQYWPNDTVPVfYGDIKVQILNDSHYA-DWVMTEFML--CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPI
|.|||  |.| ..|..|||..   | |.  .|... .  .. |...  | |   . || | .  ||| .||. |||  ...|. | |           ||
vnltrleeegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpi

VVHCSAGVGRSGTFITLDRILQQINT-SDYVDIFGIVYAMRKERVWMVQTEQQYICIHQC
|||||.|.||.|..| .| .|....     .||   .  .| .|  .|.|..|.  . ..
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
0036282 (Phosphotyrosine protein) phosphatases II 1323-1522 8.5e-48 157.6 In-house 1-164 (174) alignment 
Range on Protein: 1323-1522
Range on HMM: 1-164/174.0
GSDYINANYVPGHNSPREFIVTQGPLHstrddFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdtvpvfygdikvqilndshyadwvmtefmlCRGSE
|||||||... ..  ....|..||||      ||.|..| .....|||....|.|..|| .|||                                | ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

QRILRHFHFTTWPDFGVPNPPQtLVRFVRAFRDRIGA-EQRPIVVHCSAGVGRSGTFITLDRILQQINtSDYVDIFGIVYAMRKERVWMVQTEQQYICIH
 |   ..... |||.|||. .. | .||.. .. .   ...|..|||||||||.||.. ....|...  ...||.. .|...|. | .||||..||. ..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
0049772 (Phosphotyrosine protein) phosphatases II 1284-1536 1.3e-46 155.1 In-house 34-288 (314) alignment 
Range on Protein: 1284-1536
Range on HMM: 34-288/314.0
RDQPCTFADLPCNRPKNRFTNILPYDhSRFKLqPVDDDEGSDYINANYVPGHnspREFIVTQGPLHSTRDDF----------WRMC--WESNSRAIVM--
... ...|||..|| |||...|||.| .| .| |  . .|||||||.|| |.   . ||.|||||  | .||          |||   .. |.| |||  
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LTRCFEKGrekcdqywpN---------DTvpvfygdikvqilndshY-------AdwvmtefmlcrgsEQRIlRHFHFTTW
                   |... ..|         |                                                  |...  ... . .
devladelsrLdaAlgKtpllildgng.........neptaadlellk.................eelydpelf.............erlg.ikylripv

PDFGVPnPPQTLVRFVRAFRDRigAEQRPIVVHCSAGVGRSGTFITLDRILQQINtsdyVDIFGIVYAMRKERV-----WMVQTEQQYICIHQCLLAVLE
||...| ... . .|......    ...|..|||.||.||.|||.... .. . .    |..  ..  .|. |       .... .||. |...||  |.
pDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk

GKENIVG
 ...  .
flkkfye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1275-1526 3.2e-46 152.7 In-house 21-275 (307) alignment 
Range on Protein: 1275-1526
Range on HMM: 21-275/307.0
EFEELKHVGRDqPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCF
||..| .   .   |   . .|  |||....   |..|  ..   |   |||| |||.     |. ||..||||..|. .|| |. . .  ...|| .. 
efrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EKGREKCDQYWPNDT-VPVFYGD----IKVQILNDSHYA---DW-VMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRdrigAEQRPIV
| .. ||.|||| .      .|.    | |. |   . |   |   .|.. .  ... | ..|. .. ||| |||.   | . .. | |     .. |.|
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvv

VHCSAGVGRSGTFITLDRILQQ-INTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
|||||||||||| ...  . .. |.  .  |.  .|  .|..| . .||| ||. .|. || 
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1298-1526 3.8e-45 148.8 In-house 58-281 (290) alignment 
Range on Protein: 1298-1526
Range on HMM: 58-281/290.0
PKNRFTNILPYDHSRFKLQpvdDDEGSDYINANYVPGHNSPreFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPV-FYGD
 |||. ..   | .|  |.   |    ||. |||| | ...  ||.|||.|..|  |.|||  . .  |||||   .|.|. ||.||.|.    |  .|.
kknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

IKVQILNDSHYADWVMTEF---MLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGaeqrPIVVHCSAGVGRSGTFITLDRILQQINTSDY
| |   ....  . ..      .      . .|.|..  .|||  |..   .|.| .|. |   |    |.|||||||.||.|||....  || .     
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldGke

VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
.|. ..| |.|. |.  || . ||. . . || 
ldlldlvralrnsrlnsvqvdiqylalveilld
0043147 (Phosphotyrosine protein) phosphatases II 1321-1522 2.5e-43 143.1 In-house 2-155 (172) alignment 
Range on Protein: 1321-1522
Range on HMM: 2-155/172.0
DEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfekgrekcdqywpndtvpvfygdikvqilndshyadwvmtefMLCRG
|||||||||.|....  |..||.||||| .| .|||||..| . ..||.||..                                          .. . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

SEQRILRHFHFTTWPDFGVPnPPQTLVRFVRAFRD-RIGAEQRPIVVHCSAGVGRSGTFITLDRILqqintsDYVDIFGIVYAMRKERVWMVQTEQQYIC
 ..|   ..... |||.||| ... | .|..  ..  .  .. |..|||||||||.||.. .. .|        .... .|  .|. | ..||...||..
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IHQ
...
lyy
0046846 (Phosphotyrosine protein) phosphatases II 1316-1528 3.7e-43 142.6 In-house 4-173 (176) alignment 
Range on Protein: 1316-1528
Range on HMM: 4-173/176.0
QPVDDDEGSDYINANYVPGHnsprEFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdtvpV----Fygdikvqilndshyadwv
..  .|...||||||.. |.     .|.|||||..|  ||..| .| . .|.|.|| ..|.|| ||..|||     .    .                  
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..................

mtefmlcrgseqrilrHFHFTTWPDFGVPNPpQTLVRFVRAFRDRIGAEqRPIVVHCSAGVGRSGTFITLDRILQqintSDYVDIFGIVYAMRKERV-WM
                ..... |||.|||.  . | ..... |... .  .|..||||||.||.||.. .. .      .  .... ... .|. |  ..
................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplga

VQTEQQYICIHQCLLAVL
|||..||  .....| .|
vqtpeQyrflyefellll
subfamily_ptpA1_pd Subfamily ptpA1 1273-1485 6.8e-42 138.7 In-house 24-253 (418) alignment 
Range on Protein: 1273-1485
Range on HMM: 24-253/418.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHnSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTR
 |||  |.        .  |   |  |||.||||| .|.| .|. ..| ||||||||||. |   |..||.|||||  |  ||||| ||   | ||||.|
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsr

CFEKGREKCDQYWPNDTVP---VFY-------GDIK---VQILNDSHyADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR---
  |. | |||.|||..        |       |      |....|    . .  .  |    | | . ....  |||. .|.  | . .....  .|   
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe.reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnq

-IGAEQ--RPIVVHCSAGVGRSGTFITLDRIL
 | . .   ||.|||||||||.||| |   ..
iipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1267-1526 8.2e-42 138.0 In-house 3-257 (267) alignment 
Range on Protein: 1267-1526
Range on HMM: 3-257/267.0
DSDFRFSEEFEELKHVGRDQPCTFADLP-CNRPKNRFTNILPYDHSRFKLQPVDDDegsdYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSR
|..  . .|||..|..  ..      ..  |. .||. . ||||..|  |.  ...    |||| || |..  . |||||.||. |  ||. .  . .  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

AIVMLTRCFEkgrEKCDQYWPND-TVPVFYGDIKVQILNDSHYADWVMTEFMLC-RGSEQRILRHFHFTTWpDFGVPNPPQTLVRFVRAFRDRIGAEQRP
 ||.||. |.   ..  ..||        | |. |.   .    |. .  . |  .    . .  ...  | .  . | |     |    ....   .||
vivlltkvft...dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw.nintnnkpylkplfgilaknqlengnrP

IVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
.||.||.||||||||...|  |... | . .|||  .  .|. |. .|.| ..|| ||. |  
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1296-1534 1.2e-40 134.2 In-house 48-293 (305) alignment 
Range on Protein: 1296-1534
Range on HMM: 48-293/305.0
NRPKNRFTNILPYDHSRFKLQPVDddeGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFY-
.. |||. ..   |. | ||..       .|| ||||     |. || || ||. |  ||| ||.. .  || ||    ||| .|| .|.. .  .|.  
eagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

--GDIKVQILNDS---------HYADWVMTEFML-CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGaeqrPIVVHCSAGVGRSGTFITLD
  .. |...  .|           |.   |....   |...|   |.|.  ||| |||   .... ..   |   |    |||||||||.||.|. . |.
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmle

RILQQINTSDYVD-IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENI
 ||.|. . . ..    |.  .|..|   .||..||. .|| .|  .. |. .
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll
0049260 (Phosphotyrosine protein) phosphatases II 1331-1522 2.4e-40 133.0 In-house 1-144 (152) alignment 
Range on Protein: 1331-1522
Range on HMM: 1-144/152.0
YVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWpndtvpvfygdikvqilndshyadwvmtefmlcrgseqrilrHFH
...|.. |.||| ||||.  | .||||| .| . ..|||||...|.|..||.||.                                          ...
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILqqintsDYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
.. |||.|||. .| |  .... . ..  .. |..|||||||||.||.. .. .|        |... .|  .|. |  .|....|.. ...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1296-1529 2.8e-40 133.2 In-house 43-272 (288) alignment 
Range on Protein: 1296-1529
Range on HMM: 43-272/288.0
NRPKNRFTNILPYDHSRFKLQpvddDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP----
|  ..|..|.   | .| ||.    |.   ||.|| |. .. .| .| .| ||..| . .|.|  ||. . ||||..  |||.|| ..|.|         
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

-VFYGDIKVQIlNDSHyADWVMTEFMLCRGSE-QRILRHFHFTTWPDFGVPNPPQTLVRFVRAFrdriGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN
  .  ..|..  .| .    ... .   .  | . |... |.  |.| |||.  .. .|..  .     . |.|||||.||||||.||.|    .|... 
grlctvvkkkr.adid.klvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslr

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
 .|.. |  ..  .|.||   .|||.||. .|.|.|  | 
lddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1296-1527 9.4e-39 127.8 In-house 55-288 (305) alignment 
Range on Protein: 1296-1527
Range on HMM: 55-288/305.0
NRPKNRFTNILPYDHSRFKLqpvDDDEGSDYINANYVPGHNSP-REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTV--PV
.  |||....   |.|  ||   |.   |||| ||||     | . ||..||||  | |.|| |  . .   |||| .  | |. || ||||        
aitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

FYGDIKVQILNDSHY----ADWVMTEFMLCR-GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRdrigAEQRPIVVHCSAGVGRSGTFITLDRILQQ
. . | |. .  |.     |.  .| . |.  |...  .||...| ||| |||    | . .. | |      . |||||||||.||.|| .... ||..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair....gskvpivvhcsagigrtgtivaieyilek

INTSDY-VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|        .  .| |.| .| . .|.. ||. ||. .|  
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1294-1449 1.2e-36 121.1 In-house 31-189 (297) alignment 
Range on Protein: 1294-1449
Range on HMM: 31-189/297.0
PCNRPKNRFTNILPYDHSRFKLQPVDddEGSDYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND-TV
.    |||...|| .| .| ||. |    ..|||||.||  |  ...  .|..||||..| ||||.. .| . |.|||...  | ||.||  |||.    
nsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

PVFYGDIKVQILND--SHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRF
    ||. |. | .   ..   ..||. |   ||.| .||  | .||| |||.  . ||||
rlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
0051082 (Phosphotyrosine protein) phosphatases II 1323-1524 1.5e-36 120.6 In-house 2-149 (151) alignment 
Range on Protein: 1323-1524
Range on HMM: 2-149/151.0
GSDYINANYVPGHnspreFIVTQGPLHstrdDFWRMCWESNSRAIVMLTRCFEKGreKCDQYWPNDTvpvfygdikvqilndshyadwvmtefmlcrgse
 |||||..|| |.     .....|||.    ||... .| . ..||.|.  .| |  .| .|.|.                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDrigAEQRPIVVHCSAGVGRSGTFITLDRILQQintsdyVDIFGIVYAMRKERVWMVQTEQQYICIHQ
 . ..|.... |||.|.|  ......|.....|    .. |..||||||.||.||.. |...|..      |... ..  .|. |  .||..||......
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

CL
.|
al
0044763 (Phosphotyrosine protein) phosphatases II 1307-1525 1.7e-36 120.9 In-house 1-168 (178) alignment 
Range on Protein: 1307-1525
Range on HMM: 1-168/178.0
PYDHSRFKLQPVDDDEGSDYINANYVPGHnspreFIVTQGPLhstrDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpvfygdikvqilndsh
|.|..|..|... . |.||||||... ..     ..... |      |.... .| . ..||.||  .| |..|||.||| ..                 
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

yadwvmtefmlcrgseqrilRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQintsdYVDIFGIVYAMRKE
                     ..... .||.|||. .. . .||.. .. .  ...|..||||||||||||.. .. ....      .... ..  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RVwMVQTEQQYICIHQCLL
|  .|... |.  .... |
Rp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1285-1533 7.7e-35 114.9 In-house 41-295 (310) alignment 
Range on Protein: 1285-1533
Range on HMM: 41-295/310.0
DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY
|.  |.     .  |||.....  | || ||. .|     ||| ||||        ||..||||  |  ||||| ..  . .|..| .  |.|| ||  |
dssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPNDTVPVFYGDIKVQILNDSHYADWV---MTEFML--CRGSEQ----RIL--RHFHFTTWPDFGVPNPPQTLVRFvrafRDRIGAEQRPIVVHCSAGVG
||   |   || |.|  |..|     .      |.       ||    . |     ..  ||| |||.     |      |      . | |||||||..
wpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkd

RSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
| .. ..|.  .....  ..||.  ..  ..|.|.  .||| ||. |..  ..   |...
rlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargete
PTPc_DSPc_SM00012 1426-1525 3.2e-34 112.7 In-house 2-104 (105) alignment 
Range on Protein: 1426-1525
Range on HMM: 2-104/105.0
LRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQ--RPIVVHCSAGVGRSGTFITLDRILQQINTS-DYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
..|.|.|.|||.|||.... .....||...   ...   |.||||||||||.|||..|| .|||.... . |||| || ..||.| .|||||.||. ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLL
.||
all
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1326-1517 3.3e-32 106.5 In-house 77-270 (301) alignment 
Range on Protein: 1326-1517
Range on HMM: 77-270/301.0
YINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP-VFYGDIKVQILNDSH-YADWVMTEFMLCRGS--
 | ||..| .  |. ||.|||||..|..||| |.   .   ||||..  ||  |||..| | ..   .  |  |..| |  .   . ..   .  . |  
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

--EQRILRHFHFTTWPDFGVPNPPQTLVRFVrafrDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQY
  . | . |. ...|.| |||.    |  ..    . .   ..|||||||||.||| .||. . . .....   ...   .  .|..|   |||..| 
kfatrtvthyqysewtdrgvPkshaelfdlm....elvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1263-1531 1.9e-30 100.6 In-house 14-279 (312) alignment 
Range on Protein: 1263-1531
Range on HMM: 14-279/312.0
LMSADSdfRFSEEFEELKHVGRDQPCTfADLpCNRPKNRFTNILPYDHSRFKLQpvdDDEgSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWES
.||.    ... |.  .  .  |  || | |   .  ||. ||  .|  || |     ||   || ||.|     |  |..|||||..|   ||...   
mmstpq..qltkeykavgnivsdsect.afl.kfkdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalsl

NSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKV------QI----LNDSHYADWVMTEFMLCRGSEQRiLRHFHFTTWPDFGVPNPPQTLVRFVRA
 | .|..|.   | | ||| .|  .    |   | .|      .|        . .  |.   . . | | . | |. ...||| |.|.  .|  |.. |
gstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsa

FRDrigaEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
 .     ...|.. ||||||||.||.. .. ..  .      ..  .   .||.|   |..  ||.   .|.| .|  |
vkk....dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_CG42327_pd Subfamily CG42327 1274-1449 6.1e-30 99.0 In-house 9-186 (319) alignment 
Range on Protein: 1274-1449
Range on HMM: 9-186/319.0
EEFEELKHVGRD-QpctfADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHN-SPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
|||..|  .         .  .  ..|.|. |..|  ..|  || . ||. . |..|.|| |.. .|  .| .| .| ..  ||||. || .|| || ||
eefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

RCFEKGREKCDQYWPND-TVP--VFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFtTWPDFGVPNPPQTLVRF
  .|.| ..| .|.|   | .    ||||.| . .      .... ..| |  ..| | | |. .  |.. .||  ...|.  
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1287-1530 5.3e-28 92.8 In-house 26-272 (285) alignment 
Range on Protein: 1287-1530
Range on HMM: 26-272/285.0
PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDddegSDYINANY--VPGHNSpREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY
 ||..   .|   ||....   . .|  |.  |     ||| |..  .||..    .| |||||  |  |||.| .. .   ..||   || | |||  |
nctytayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPNDTVPV-FYGDIKVQI--LNDSHYADWVMTEFMLCR----GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRaFRDRIGAEQRPIVVHCSAGVGRSGT
.|.    |  .|  .. .   ..   |  ..  . .       ||   . | .   |||   |.  . .. . . .  ..  ...||.|||||||||. |
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk.wvkkvnpkekpicvhcsagvgrtat

FITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
|. .|    .|     .... ||  ||  |.  ||.  |.. ..  |.  . |
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_egg_pd Subfamily egg 1288-1542 1.2e-27 91.4 In-house 32-281 (307) alignment 
Range on Protein: 1288-1542
Range on HMM: 32-281/307.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKgrEKCDQYWP-
 | |    |. | |   .   | || ||.        |.| ||.| |.    |||..| ||  | |||||| .. . . |||||   |   |.|. ||| 
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

--NDTVPVFYGDIKVQILNDSHYADWV--MTEFMLCRG-SEQRILRHFHFtTWPDFGVPNPPQTLVRFVRafrDrigaEQRPIVVHCSAGVGRSGTFITL
  .|.. .  | .... |.  . || .  .|.. |  |  |.| | |.    .   .    |  ..| .|   .      .|.||..  || ...|....
aesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklr...n....lskpvvvqdilGvskaatlvai

DRILQQIN-TSDY-VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLegkENIVGPAREMH
.  | ..     .   .   |  .|..|   |..  .|. ... .| ..    ...| |.|. 
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff...rdvigsakeld
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1299-1401 5.1e-26 86.2 In-house 50-162 (350) alignment 
Range on Protein: 1299-1401
Range on HMM: 50-162/350.0
KNRFTNILPYDHSRFKLQ----PVD----DDEGSDYINANYVPGH------NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY
|||..|||||.||| ||.    . |      ...|||||||.         |.   .| ||.|| || |||.... . . . |..||  .| ..|||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPNDTvpvfYGDIKVQI
|.. .    | ||.|..
Wqegs....ydditvkl
0048076 (Phosphotyrosine protein) phosphatases II 1420-1525 1.2e-23 78.8 In-house 41-140 (145) alignment 
Range on Protein: 1420-1525
Range on HMM: 41-140/145.0
GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEqRPIVVHCSAGVGRSGTFITLDRILQqintsDYVDIFGIVYAMRKERVWMVQTEQQYIC
  . |   ..... |||.|||. ...| .|... .. . .. .|..|||||||||.||.. .. .|.       |... ..  .|. | ..|....|.. 
ellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

IHQCLL
.....|
lyefel
0048179 (Phosphotyrosine protein) phosphatases II 1424-1522 9.9e-23 75.9 In-house 47-139 (144) alignment 
Range on Protein: 1424-1522
Range on HMM: 47-139/144.0
RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGaEQRPIVVHCSAGVGRSGTFITLDRILqqintSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
|   ..... |||.|||. .. | .|...... .  | .|..|||||||||.||........        .... ... .|. | ..|....|.. ...
regiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1409-1530 2.2e-22 74.0 In-house 76-196 (440) alignment 
Range on Protein: 1409-1530
Range on HMM: 76-196/440.0
DWVMTEFMlcRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRD-RIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKER
|.. . ..   | | | |...|.  ||| |||.    ......   . .  | . |..||||||.||.|  |..| ||.. . || .||| .. .||..|
dyinasyi..ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnr

VWMVQTEQQYICIHQCLLAVLEG
  |||| .||  .|...|  |  
pqmvqtpeqyafvheavlegllc
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1335-1522 2.3e-20 67.6 In-house 1-198 (199) alignment 
Range on Protein: 1335-1522
Range on HMM: 1-198/199.0
HNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfEKGRE-KCDQYWPNDT-VPVFYGDIKVQILNDSHYADWVMTEFMLCRG----SEQRILRH
|.. | .|.|| ||. |  |||.| ||. |  |||.    .| .|     |||        || . |     .  .|...| ..|.         | . |
hkgqrryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreish

FHFTTWPDFGVPNPpQTLVRFVRAFRDRIG---A-EQRPIVVHCSAGVGRSGTFITLDRILQQINTS--DYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
. ||.| .   ||    .| || | |.         . |..|||| | | .| |..||  ..  . |    ||.| .   .|. |. .. . |.|  |.|
yqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1339-1522 4.3e-20 66.7 In-house 4-197 (198) alignment 
Range on Protein: 1339-1522
Range on HMM: 4-197/198.0
REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfEKGRE-KCDQYWPNDT-VPVFYGDIKVQILNDSHYADWVMTEFMLCRG----SEQRILRHFHFT
| .|.|| ||. |  |||.| ||. |  |||.    .| .|     |||        || . |     .  .|...| ..|.         | . |. ||
rryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDFGVPNPpQTLVRFVRAFRDRIG---A-EQRPIVVHCSAGVGRSGTFITLDRILQQINTS--DYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
.| .   ||    .| || | |.         . |..|||| | | .| |..||  ..  . |    ||.| .   .|. |. .. . |.|  |.|
swkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1296-1528 2.4e-18 60.6 In-house 51-285 (302) alignment 
Range on Protein: 1296-1528
Range on HMM: 51-285/302.0
NRPKNRFTNILPYDHSRFKLQPVDDdegsDYINANYVPGHNSPREFIVTQGPLHSTR---DDFWRMCWESNSRAIVMLTRCFEKGReKCDQYWPND-TVP
|  ||. ...  .|. . ||.   |    .|.||  |   .  |. |..| |  ..    ..|||| .. .   .|.| .  |  .   ....|.     
nlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

VFYGDIKVQILNDSHYADWV---MTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF-RDRIGAEQrPIVVHCSAGVGRSGTFITLDRILQQ
. ||.. | .   ..  . .   . | .    |.  .    ..| |..  ||    .|.. .       | |.. ..|.    |.|| |.|.||   ...
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade.ntvivSknGaGRagafltlavavek

INTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..... . |  || ..|..|  .|.. .||. .. .||  .
lqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1421-1526 6.3e-18 59.6 In-house 212-342 (350) alignment 
Range on Protein: 1421-1526
Range on HMM: 212-342/350.0
SEQRILRHFHFTTWPDFGVPNPPQTLVRFVR----------AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQ----------QINTSDYV-----D
|.  .. ....  |.| .. . |. ... .           |      |.. ||.||||||||| ||..||| .|.          . . .|.       
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IFGIVYAMRKERVWMVQTEQQYICIHQCLLA
|. ||  .|| |. |||. .|.| |...|| 
isiivnelrkqrismvqnldqfifiYeallf
fn3 Fibronectin type III domain 585-658 1.4e-17 56.7 Pfam-A 2-79 (85) alignment 
Range on Protein: 585-658
Range on HMM: 2-79/85.0
PPRNMTIETVRSNSVLVHWSPPE--SGEFTEYSIRYRTDSEQQ-WVRLPSVRST-EADITDMTKGEKYTIQVNTVSFG
.|.|.... |.|.|. ..||||.  .|..| |...||...... |..    |.| .. .|... | .|...| .|. .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1350-1511 1.1e-16 55.7 In-house 38-204 (255) alignment 
Range on Protein: 1350-1511
Range on HMM: 38-204/255.0
S-TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTV-PVFYGDIKVQILNdsHYADWVMTEFM-L-CRG--SEQRILRHFHFTTWPDFGVPNPP
| | | |...   ...  .|||.   |.|.|||..|.| .      . |..|   .    || |.     .   |   . . ..|.... |..   |. .
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

QTLVRFVRAFRDrigaeQRPIVVHCSAGVGRSGTFITLDRILQ----QINTSDYVDI--FGIVYAMRKERVWMV
. .   ... ||      ...|||||.|.||| .|.  . . |    ...|.. |..    ..  .|..|   .
reilnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkrai
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1323-1522 1.2e-16 55.8 In-house 45-253 (290) alignment 
Range on Protein: 1323-1522
Range on HMM: 45-253/290.0
GSDYINANYVPGHNSpREFIVTQGPLHS-------TRDDFWRMCWESNSRAIVMLTRCFEKGRE----KCDQYWPNDTV-PVFYGDIKVQILNDSHYADW
 .||| ||.|   |   ..|.|| |..        |  .|| |  . ... .|||    || ..     | .| |.     . .....|.  .  .  | 
nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

VMTEFMLC-RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVrafrDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN-TSDYVDIFGIVYAMRKERV
 . | ..   . |.  . |  .  | .  |.. ..||.  .    . . |.. |..|||  |. || .. ...   | |  ||. | .  ...|.||.| 
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsli....qkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

WMVQTEQQYICIHQ
 ........  .  
laitsalelafvda
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1295-1522 3.1e-16 53.8 In-house 46-273 (303) alignment 
Range on Protein: 1295-1522
Range on HMM: 46-273/303.0
CNRPKNRFTNILPYDHSRFKLQpvdDdegSDYINANYVPgHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFY
 |  ||||....  |||. ||    |   | || |.|.   .| .  |.|| ||  |  |||.|  | . . ...|    |  .   |  .|..   . .
knmdknrfvdvicldhskvkls...d...ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GD--IKVQILNDSHY-ADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNP-PQTLVRFVRAFRD--RIGAEQRPIVVHCSAGVGRSGTFITLDRI-LQQ
 .  |.|  ..       ||.    .  |. . .|   |. .||   .|.     .|. .   .   |  .. .| |    .|.||.|||  ..   |  
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

INTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
 .    .|.   .  .|. |.  ||   |.  .. 
hseqasldlvkclenvrngrlhavqnlsqfsvvyt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1299-1407 6.3e-16 52.6 In-house 51-171 (349) alignment 
Range on Protein: 1299-1407
Range on HMM: 51-171/349.0
KNRFTNILPYDHSRFKLQP----VDD----------DEGSDYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCD
|||. .||||.||| ||.                      |||||||.  .  .  . .| || || || |||...    . . .. |.  .|.. ||||
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPNDTvpvfYGDIKVQILNDSHY
.|| . .    | .|.|.. | | |
iywqels....ysnitvklqnssly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1346-1531 1.2e-15 51.7 In-house 98-291 (302) alignment 
Range on Protein: 1346-1531
Range on HMM: 98-291/302.0
GPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVF-YG-------DIKVQI--LNDSHYADWVMTEFMLCRG--SEQRILRHFHFTT
 | .||.. .| .  . |   .| |.   |.. .|| .|. ..   .. .|       ..| ..  . | . .     |.   .     .. .  ..|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDFGVPNPPQTLVRFVRaFRDrigAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
||| | |. ..| .  .. | .   . .. ..|||||||||.||....   .|   . .  |.  ||  .|. |   ||.||| | .  |.   |  |
wpdhGapkeaytaldilk.fce...sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek
subfamily_eak_pd Subfamily eak 1300-1441 1.4e-15 51.6 In-house 56-196 (332) alignment 
Range on Protein: 1300-1441
Range on HMM: 56-196/332.0
NrFTNILPYDHSRFKLQPVDDDEgSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDT-VPVFYGDIK
|   .|.|||.   .| .   ..   ||||  .   .  |..|.|  . ..    ||.|  | .| |||.|    |.. || |.|.|..|   . .| ..
n.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPN
|.  .  . .   .  ..| .| |   . |...  | .. .| 
verkefvkrniletrllelskGnethrvlhykvfGwtettlpk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1464-1528 3.9e-15 50.0 In-house 1-65 (69) alignment 
Range on Protein: 1464-1528
Range on HMM: 1-65/69.0
IVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
.|||||.| ||.||||..   . .| .   ||||  |  ||| |  ||  |..|| ||  |   |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
fn3 Fibronectin type III domain 866-936 7.2e-15 48.1 Pfam-A 2-79 (85) alignment 
Range on Protein: 866-936
Range on HMM: 2-79/85.0
PITQLHATNITDTEISLRWDLP---KGEYNDFDIAYLTADNL--LAQNMTTRNE--ITISDLRPHRNYTFTVVVRSGT
....|.....|.|...|.|. |   .|..  ... | ....     .  ..|..   |...|.|...|.|.|  ..| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_hpo-7_pd Subfamily hpo-7 1348-1507 1.7e-14 48.3 In-house 43-206 (263) alignment 
Range on Protein: 1348-1507
Range on HMM: 43-206/263.0
LHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTV-PVFYGDIKVQILNDSHyaDWVMTEFMLCR--G--SEQRILRHFHFTTWPDFGVPNP
|  | | |...   ...  .|||.   |.|.|||..|.| .      . ...|   .  .  | ..    |    |   . . ..|. .. |..   |. 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PQTLVRFVRAFRDrigaeQRPIVVHCSAGVGRSGTFITLDRILQ----QINTSDYVDI--FGIVYAMRKER
..  .. ... |.      ...|||||.|.|||  |   . . |    ...|.. |..    ..  .|..|
areilnilkvarn.....skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssr
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1465-1528 3.3e-14 47.0 In-house 1-64 (69) alignment 
Range on Protein: 1465-1528
Range on HMM: 1-64/69.0
VVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|||||.| ||.||||..   . .| .   ||||  |  ||| |  ||  | .|. ||. |   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_CG42327_pd Subfamily CG42327 1460-1524 7e-14 46.2 In-house 246-311 (319) alignment 
Range on Protein: 1460-1524
Range on HMM: 246-311/319.0
EQRPIVVHCSAGVGRSGTFITLDRILQQINTS-DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCL
.| |.||||| ||||.|. |. |  ......|   |||  .|. .|..|   |.| .||  |.. |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1289-1445 1.9e-13 43.6 In-house 19-159 (169) alignment 
Range on Protein: 1289-1445
Range on HMM: 19-159/169.0
TFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINAnyvpghnsprefivtqgplhstrddfwRMCWESNSRAIVMLTRCFEKGR---EKCD-QY
 .|.| ||  ||| .  |   | | ||| | .| |||||||                           || ||.|.  ||.|  . .|     || | | 
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyql

WPNDTVPVFYGDIKVQILNDSH---YADWVMTEFMLCRGSEQRILRH----FHFTTWPDFGVPNPPQT
 |   .  .| |      .  |    .   . | .|. .| .. . .    .|..|||. |||. |  
hpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh
fn3 Fibronectin type III domain 407-485 3.2e-13 42.8 Pfam-A 2-82 (85) alignment 
Range on Protein: 407-485
Range on HMM: 2-82/85.0
PVRNLRSINDdKTNTMIITWEADP--ASTQDEYRIVYHELETFN-GDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMES
...||. ..   .... ..|.. .   .. . |.. | | .. .   . |.. . |..||. | ||..|...||||... |.
aPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1289-1445 1.1e-12 41.2 In-house 20-160 (169) alignment 
Range on Protein: 1289-1445
Range on HMM: 20-160/169.0
TFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINAnyvpghnsprefivtqgplhstrddfwRMCWESNSRAIVMLTRCFEKGR---EKCD-QY
 .|.| ||  ||| .  |   | | ||| | .| |||||||                           || ||.|.  ||.|  . .|     || | | 
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyql

WPNDTVPVFYGDIKVQILNDS----HYADWVMTEFMLCRGSEQRIL---RHFHFTTWPDFGVPNPPQT
 |   .  .| |      .      .  . ..   |.    .. .    . .|..|||. |||. |  
hpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1250-1346 2.1e-12 41.1 In-house 3-95 (95) alignment 
Range on Protein: 1250-1346
Range on HMM: 3-95/95.0
RPILIKNFAEHYRLMSADSDFRFSEEFEELKHvGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDdegSDYINANYVPGHNSPREFIVTQG
.|| .  |  |   | ..||  | .||  .       | |     .| ||||| ||.||| .|  |    |   |||||| .| |.     .| .||
kpihvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 961-1043 5e-12 39.0 Pfam-A 3-84 (85) alignment 
Range on Protein: 961-1043
Range on HMM: 3-84/85.0
VERFHPTDVQPSEINFEWSLPSsEANGVIRQFSIAYTNINNLT-DAGMQDFESEEaFGVIKNLKPGETYVFKIQAKTAIGFGPE
.|... ..|........|| |. . .| |  ... | . ..   .   .  ....   ....|||| .|.|..|| .. | |||
PenlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 220-299 5.9e-12 38.8 Pfam-A 3-80 (85) alignment 
Range on Protein: 220-299
Range on HMM: 3-80/85.0
PGKFIVWFRNETTLLVLWQPP-YPAGIYTHYKVSIEPPDANDsvlyVEKEGEPPGPA-QAAFKGLVPGRAYNISVQTMSEDE
|. . |  ...|.| . |.||  . | .|.|.|  .. . ..    ..||   |... .. ..|| ||. |...||. ... 
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngag
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1249-1337 6.1e-12 39.6 In-house 3-88 (440) alignment 
Range on Protein: 1249-1337
Range on HMM: 3-88/440.0
NRPILIKNFAEHYRlmSADSDFRFSEEFEeLKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNS
.|||.. .||.. .  .      | .|.  |   |  ||.  | || |. |||. ||| |||||  |. |     |||||| |. | .|
qrpiivadfadyvq..nnrrsrafedews.llpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1459-1528 6.8e-12 39.4 In-house 263-344 (349) alignment 
Range on Protein: 1459-1528
Range on HMM: 263-344/349.0
AEQRPIVVHCSAGVGRSGTFITLDRILQ--QINTSDYVD----------IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..  ...|||||| ||.|...||| .|.  .  . ...           |. ||  .|| |. |||  .|.| |...||  .
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
fn3 Fibronectin type III domain 124-202 4e-11 36.1 Pfam-A 1-79 (85) alignment 
Range on Protein: 124-202
Range on HMM: 1-79/85.0
DPPSNLSVQVRSGKNAIILWSPPT--QGSYTAFKIKVLGLSEASssYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDG
..|.||||  ..  .. . ||||.  .| .| .....   .. .  . ..|.|  .| .. ...|.||..|... ... ..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 315-391 1.2e-10 34.5 Pfam-A 3-79 (85) alignment 
Range on Protein: 315-391
Range on HMM: 3-79/85.0
PLNVTFDRDfiTSNSFRVLWEAPK-GISEFDKYQVSVATTRRQS-TVPRSNEPVA-FFDFRDIaEPGKTFNVIVKTVSGK
| |....    ||.|... |..|| | .....|.| ..... .. .. ..... .  . .... .||..... |..|.|.
Penlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgL.kpgteYefrVqavnga
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1462-1527 2.7e-10 34.6 In-house 229-294 (297) alignment 
Range on Protein: 1462-1527
Range on HMM: 229-294/297.0
RPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
 ...|||||||||||  .  | ||...      |.  |.  .|..|  .||| .|.  ...  |. 
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1306-1416 1.6e-09 32.2 In-house 3-100 (130) alignment 
Range on Protein: 1306-1416
Range on HMM: 3-100/130.0
LPYDHSRFKlqpvdddeGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfekgrEKCDQYWPnDTVPVF-Y-GDIKVQiLN
|... || .        | .||||..|   .  .|.. || ||  |  |||.|  |     .|.|        |. |.||| |. |.  |  || |  | 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.....eeedeywp.dsePlewyeediivt.lt

DSHYADWVMTEFM
| .  . . ....
drdefknikasnl
fn3 Fibronectin type III domain 683-753 6.9e-09 28.9 Pfam-A 11-77 (85) alignment 
Range on Protein: 683-753
Range on HMM: 11-77/85.0
VDSRNITLEWPKP---EGRVESYILKWWPSDNPGRVQTKNVSENksaddlsTVRVLIGELMPGVQYKFDIQTTS
| |...||.| .|   .| ...| ..........  ....|...       | .| . .| || .|.| .|. .
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.......ttsvtltgLkpgteYefrVqavn
PTEN_1 1433-1480 8.5e-09 30.5 In-house 101-149 (196) alignment 
Range on Protein: 1433-1480
Range on HMM: 101-149/196.0
TWPDFGVPNpPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFIT
 ..|.|.|.  . | .... | . . .  ... ..||| ||.||||| . 
pieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1272-1335 9.2e-09 29.3 In-house 15-77 (244) alignment 
Range on Protein: 1272-1335
Range on HMM: 15-77/244.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPvDDDEGSDYINANYVPGH
  |||  |    |.   | | | .|  |||. ||||.|..|  |      ||||||||||. | 
akeefvglsdhtreflqtnavlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs
fn3 Fibronectin type III domain 511-570 1e-08 28.4 Pfam-A 16-80 (85) alignment 
Range on Protein: 511-570
Range on HMM: 16-80/85.0
LNISWKSD--VNSKQEQYEVLYSRNGTSD-LRTQKTKESR--LVIKNLQPGAGYELKVFAVSHDL
|..||.     ... . ||| |.  |...  ........   .....|.||. ||..| ||. . 
ltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1288-1368 1e-08 29.1 In-house 29-114 (347) alignment 
Range on Protein: 1288-1368
Range on HMM: 29-114/347.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDD-----DEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIV
.|...   .  |||  .    | .|  | | .      |.   |||| ..   |. .|.|.|| || .|  |||.|    .   .|
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1286-1381 3.5e-08 27.3 In-house 24-118 (332) alignment 
Range on Protein: 1286-1381
Range on HMM: 24-118/332.0
QPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDegSDYINANYVPGHNSPREFIVTQGPLHS-TRDDFWRMCWESNSRAIVMLTRCFEKGREKC
 | |.  .  |   ||   .  .|||| .| | |     |. ||..| |..    .|..| |.   |   ||||  | .   |...    || . |.
ypntydkflnnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
Tissue_fac Tissue factor 584-657 7.8e-08 21.1 Pfam-A 23-101 (107) alignment 
Range on Protein: 584-657
Range on HMM: 23-101/107.0
NPPRNMTIETVRSNSVLvHWSP-PESGEFTEYSIRYRTDSEQQWVRL---PSVRSTEADITDMTK--GEKYTIQVNTVSF
 .|.|......  ...| .|.| ..| | . |.. |.. |..|| ..    ....|| |.|. |.   |||...| ..| 
pkPqnvqfqsrnfkniL.sWepgsaspesvvYtVqykmkssrqwknvedCtniteteCDLtsetsdiqekyyarVraesg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1339-1399 1.2e-07 25.4 In-house 236-293 (440) alignment 
Range on Protein: 1339-1399
Range on HMM: 236-293/440.0
REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKgreKCDQYWPNDTVPVFYGDIKV
  || || || ||  ||||.  . .  .|.|| .  .|    |  ||| .|  | .| . |
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftv
0038934 (Phosphotyrosine protein) phosphatases II 1430-1480 1.8e-07 26.5 In-house 83-134 (194) alignment 
Range on Protein: 1430-1480
Range on HMM: 83-134/194.0
HFTTWPDFGVPNPPQTLVRFVRAFRDRIGAE-QRPIVVHCSAGVGRSGTFIT
.   .||.|.. . ..| ||...  . . .  .  ..||| ||.||.||.. 
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_PTPDC1_pd Subfamily PTPDC1 1429-1524 2.6e-07 25.3 In-house 85-172 (182) alignment 
Range on Protein: 1429-1524
Range on HMM: 85-172/182.0
FHFTTWPDFGVPnPPQTLVRFVRAFRDRIGAEqrPIVVHCSAGVGRSGTFITLDRILQQINTSDYvdifgIVYAMRKERVWMVQTEQQYICIHQCL
..  .|.|.||. . ....  |.     .  .   . ||| || || |  |.   . ..  |..       .  .|..|   .|| .|  ....  
vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaek.....aiklvrskrpksiqtreqvelvkefa
0048567 (Phosphotyrosine protein) phosphatases II 1429-1530 5.1e-07 24.2 In-house 40-148 (157) alignment 
Range on Protein: 1429-1530
Range on HMM: 40-148/157.0
FHFTTWPDFGvPNPPQTLVRFVRAFRDRI---GAEQRPIVVHCSAGV---GRSGTFITLDRILQQinTSDYVDIFGIVYAMRKERVWMVQTEQ----QYI
.... . ||| | .  .|.||.. . . .     . ..|.|||.||    ||..|.| .  || .    .  ......  .|   |.  .  .    ...
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl..gftpeeaiaplrivrpgsvpfrdasyllslynl

CIHQCLLAVLEG
... .| ..| .
tlldvlyGllkA
fn3 Fibronectin type III domain 785-850 5.3e-07 22.9 Pfam-A 12-79 (85) alignment 
Range on Protein: 785-850
Range on HMM: 12-79/85.0
ERDTITLSYTPTPQSSSKFDIYRF---SLGDAEiRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGG
  ...||| .| .. ..... |.    . |. |  .||. .  | . ||.||| ||. |...| .|.|.
tstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1340-1403 5.8e-06 20.1 In-house 138-197 (244) alignment 
Range on Protein: 1340-1403
Range on HMM: 138-197/244.0
EFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfekgrEKCDQYWPNDTVPVFY-GDIKVQILN
|.|.|| ||  |  |||.|  |     .|.|        |. |.|||.     .|  || | . .
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.....eeedeywpdseplewyeeditvtltd