Gene Ptp10D in Drosophila melanogaster

Synonym: 10D, CG1817, CT4920, DPTP, DPTP10D, DPTP[[10D]], Dmel\CG1817, PTP10D, Ptp10, R-PTP 10D, dptp, ptp10D, Dmel_CG1817, Ptp10D

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP047_AA protein Get Run
DmelP047_AA_1254-1529 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 1247-1533 9.2e-141 463.0 In-house 2-290 (293) alignment
Range on Protein: 1247-1533
Range on HMM: 2-290/293.0
EQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQG
....|| ...|.||.. |.||||.|||||.||||.||.|| ...|.|..|| |||.||||||||||.||....|..|||||||||.||.|||||||.|||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTL
||..|.||||||.||..|..|||||...|||..||..|||.|. ||.||||||........ |||. |.......|.| .|..|||.|||.|||. ..||
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

VRFVRAFRDRI--GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
..|||..|..|   |..|||||||||||||.||||.|||.||.|...|||||||||...|.||...||||.|||.||||.|..|. ||.
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee

subfamily_PTPRD_pd Subfamily PTPRD 1250-1530 2.6e-113 374.6 In-house 3-283 (564) alignment
Range on Protein: 1250-1530
Range on HMM: 3-283/564.0
RPILIKNFAEHYRLMSADSDFRFSEEFEELKHVgRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLH
.|| .....||.. . |.||..|.||......  .  ... |. |.|..|||. ||..||||| .|..|. |||||||||... |.......| |||||.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

STRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLV
.| .|||||.|| ||. |||||.. |||..||..|||... .  ||...|.. .  ..|| ....| | .   ||.|  |.|||| ||| |||. ...|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

RFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
...|  |.    .. ||||||||||||.||||..| .|..|.... |||...| |.||.|  |||||.||| ||. .|  |. 
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac

0051299 (Phosphotyrosine protein) phosphatases II 1249-1527 2.6e-102 337.4 In-house 2-285 (288) alignment
Range on Protein: 1249-1527
Range on HMM: 2-285/288.0
NRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL
...| ......... . |..  .. |||||| ..  | ....| ||.|..|||...|||||||| ||...|..||||||||.|..|.|..|.||.|||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

HSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdTVPVFYGDIKVQILNDSHYADWVMTEFMLC------RGSEQRILRHFHFTTWPDFGVPNP
..| .|||||.|| |.| |||||...|.|||||.||||.   .. ||||.| .|.  ...|........        ..| |. .|||.|.|||.|||. 
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

PQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|. |..|.|..|. . . . |.||||||||||.||||.|| .|.|...   ||....|  .|. |  ||||..||. ....||  
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0050432 (Phosphotyrosine protein) phosphatases II 1243-1531 1.7e-100 331.6 In-house 17-302 (308) alignment
Range on Protein: 1243-1531
Range on HMM: 17-302/308.0
DSVIEQNRPILIKNFAEHYrlMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLqpvddDEGSDYINANYVPGH--NSPRE
.|.   . .. ........  ..|..  ...|||||| .|  . ....| ||.|..|||...|||||||| ||     |||||||||.||.|.  ..||.
tsilvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprk

FIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND--TVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPD
||.|||||..| .|||||.|| |.| |||||...|.|||||.||||..    .. ||...| .|.  ...|.......|.   ..| |...|||.|.|||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

FGVPNPPQTLVRFVRAFRDRIgaEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
.|||. |. |..|... |...  .. ||||||||||||.||||.|| .|.|...   ||.|..|. .|. |  ||||..||. ....||  |. |
hgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

0040438 (Phosphotyrosine protein) phosphatases II 1255-1528 3.9e-98 323.9 In-house 3-276 (317) alignment
Range on Protein: 1255-1528
Range on HMM: 3-276/317.0
KNFAEHYRLMSADSDFRFSEEFEELKHVGRDqPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDD
... ... .. . .  ...||||.| ..  | ....| ||.|..|||...|||||||| ||.|.. |..||||||.||.|.| .|.||.||||| .| .|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRA
||||.|| ... |||||...|.|||||.||||.   .. |||..|..|.  ..|.........   ..||.|...|||.|.|||.|||  |..|..|..|
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

FRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
 |. .  .. |..|||||||||.||||.....|.|...   ||.. .|. .|. |  .|||..||. ....||  |
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0036941 (Phosphotyrosine protein) phosphatases II 1262-1533 1.9e-96 318.1 In-house 5-282 (297) alignment
Range on Protein: 1262-1533
Range on HMM: 5-282/297.0
RLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLqpvdDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWE
.|.....  ....||||| ..  . ... | ||.|..|||...||||||.| ||    ||||||||||.||.|.. .|.||.|||||..| .|||||.||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

SNSRAIVMLTRCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSH--YADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR
 |.. |||||...|.|||||.||||..   .. |||..|. |. ..  ..|...... .    ..|.|...|||.|.|||.|||. |..|..|....|..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

IGA--EQRPIVVHCSAGVGRSGTFITLDRILQQIN---TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
. .  .. |..||||||||||||||..| .|||..   .   |||. .|  .|. | ..|||..||. ....||  |  |..
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1252-1533 7.4e-96 315.9 In-house 2-285 (318) alignment
Range on Protein: 1252-1533
Range on HMM: 2-285/318.0
ILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHST
| ......| | . .. .  .|||.|.|... .    . .  |.|. |||..|||.|||.| |||.....||||||||||..|... ...| .|.||  |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

RDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCRG--SEQRILRHFHFTTWPDFGVPNPPQTLVRF
 .||||| || ||. |||||.. |.|..|...|||..  .  ||...|.. .. ...|.|. || . |   .|.|. | .|.|.||| |||. . .|. .
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

VRAFRDRI-GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
||  .     ....|||||||||||| |.||..| .|..|.    ||.|..|  .|..|  |||||.||. |.. ||  |.  . 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt

0039614 (Phosphotyrosine protein) phosphatases II 1246-1528 1e-95 315.8 In-house 8-289 (297) alignment
Range on Protein: 1246-1528
Range on HMM: 8-289/297.0
IEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDqpCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDD-DEGSDYINANYVPGHNS-PREFIV
. .. || .. .. ...|. |.|  .. .|||||. .  |  ...| ||.|..|||...|||||||| ||.|.|. |..||||||.||.|..  .|.||.
llesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

TQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGReKCDQYWPNDTVpvFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPP
|||||..| .|||||.|| ....|||||...|.|| ||.||||...    |||..|  |.  |......... . ...| |...||..| |||.|||. .
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

QTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..| .|... |... .  ...|..|||||||||.||||.....|.|...   ||.. .|  .|. | ..|||..||. ....||  |
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

0046845 (Phosphotyrosine protein) phosphatases II 1272-1529 1.9e-95 314.8 In-house 2-275 (284) alignment
Range on Protein: 1272-1529
Range on HMM: 2-275/284.0
FSEEFEELKHVGRDQ--PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDD-EGSDYINANYVPGH-----NSPREFIVTQGPLHSTRDDFWRMCWESN
. |||||| ..  ..  ....| ||.|. |||...|||||||| ||...|.| |.||||||.||.|.     .....||.||||| .| .|||||.|| |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG--
.| |||||...|.|||||.||||..  .. |||..| .|.  .. |.......| .   ..| |...|||.|.|||.|||  |. |..|.|. |. .   
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSD---YVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
  . ||||||||||||.||||.|| .|.|... .    ||....|. .|. |  ||||..||. ....||  | 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0043336 (Phosphotyrosine protein) phosphatases II 1254-1525 4.8e-94 310.2 In-house 4-274 (278) alignment
Range on Protein: 1254-1525
Range on HMM: 4-274/278.0
IKNFAEHYRLMSADSDFRFSEEFEELKHVGRdQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRD
.|....... . ...  ....||||| ..    ....| ||.|..|||...|||||||| ||.... |..||||||.||.|.| ||.||.|||||..| .
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPndTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVR
|||||.|| ... |||||...|.||.||.||||    .. |||..|  |.  |..|.... . .   . .| |. .|.|.. |||.||| ....|..|..
dFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
|.|...  .. |..|||||||||.||||.|...|.|...   ||.. .|  .|. | ..|||..||. ....||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0047943 (Phosphotyrosine protein) phosphatases II 1262-1526 2.3e-93 307.9 In-house 4-270 (273) alignment
Range on Protein: 1262-1526
Range on HMM: 4-270/273.0
RLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLqpvdDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWE
.|.....  .. ||||.|. .  . ....| ||.|. |||...|||||||| ||    .|.|||||||.||.|.|..|.||.||||| .| .|||||.||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

SNSRAIVMLTRCFEKGREKCDQYWPNDTV--PVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRI
 |.| |||||...|.|||||.||||..    .. ||...| .|.  ...|.......| .   .| |. .|||.|.|||.|||  .. |..|... |. .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GA--EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
 |  .. |.||||||||||.||||.|| .|.|...   ||.. .|. .|. |  ||||..||. ....|| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1251-1529 1.1e-92 305.2 In-house 3-280 (288) alignment
Range on Protein: 1251-1529
Range on HMM: 3-280/288.0
PILIKNFaEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHS
||.|..  ..   .||..   ||||.. |  .....  | . |. | .|||. ||||||. | ||. ... .|.|||||.|. |... ...| ||||| .
pihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPlad

TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFV
| .|||.. .| ..  |||||   |.|..||..|||..  |. ||...|..... .  |.|. ...| .  ... . ......||| |||.  . |. ..
tvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllell

RAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|       |.. ||.|||||||||.||||.|| ........||.|..|.|  .||.|  .|||..||. |...|| . |
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie

0045450 (Phosphotyrosine protein) phosphatases II 1250-1528 1.4e-92 306.0 In-house 7-304 (307) alignment
Range on Protein: 1250-1528
Range on HMM: 7-304/307.0
RPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGR--DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDD-EGSDYINANYV--------PGHNSP
..| ....  ...|. .|.  .. .|||.|..|      ....| ||.|..|||...||||||.| ||...|.. |.||||||.||        .|....
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLC---RGSEQRILRHFHFTTWP
|.||.|||||..| .|||||.|| ....|||||...|.|||||.||||..  .. ||...|  |. .|....... . .      .| |...|||.|.||
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DFGVPNPPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|.|||  ...|..|... |. ...  .. |..|||||||||.||||... .|.|...      ||.. .|  .|. | ..||...||. ....||  |
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

DSPc_SM00195 1272-1528 2.3e-91 301.2 In-house 2-262 (263) alignment
Range on Protein: 1272-1528
Range on HMM: 2-262/263.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
..||||.|.    ....| |. . |. |||..|||||||.| ||.. ...||||||||||. |.|.....|.||||| || .|||||.|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYA-DWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVH
...|.|.||||.|||..   .  .|.|.|.. .  ..  ....... |      |.| ........||| |||. .. .....||.. .   .. |||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|||||||.|||.|.| ||..... . |||| || ..||.|  ||||..||. |....|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1272-1528 2.3e-91 301.2 In-house 2-262 (263) alignment
Range on Protein: 1272-1528
Range on HMM: 2-262/263.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
..||||.|.    ....| |. . |. |||..|||||||.| ||.. ...||||||||||. |.|.....|.||||| || .|||||.|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYA-DWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVH
...|.|.||||.|||..   .  .|.|.|.. .  ..  ....... |      |.| ........||| |||. .. .....||.. .   .. |||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|||||||.|||.|.| ||..... . |||| || ..||.|  ||||..||. |....|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRG_pd Subfamily PTPRG 1253-1536 7.6e-88 290.1 In-house 2-295 (563) alignment
Range on Protein: 1253-1536
Range on HMM: 2-295/563.0
LIKNFAEHYRLMSADSDFRFSEEFE--ELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGS-DYINANYVPGHNSPREFIVTQGPLH
 .|.||.|   . ||.| .||||||  . ... .| ...... |.|. ||| .||..||.|| ||.|. . ... |||||||. |..  ..||.|||||.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

STRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCR-----GSE---QRILRHFHFTTWPDFGVPN
.| |||||| || |.  |||.|   |.||.|||.|||.|. .. || ..|.. .  . |   . ....       ...   ..  |..|.|.||| |||.
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkde.setygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

PPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVG
 .   . ||.       ||  ||||||||||||.||.| || .|.||.. . |..||..  .| .|  .|||| ||| .|. || .. .||. . 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1249-1531 9.9e-84 276.1 In-house 2-286 (319) alignment
Range on Protein: 1249-1531
Range on HMM: 2-286/319.0
NRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDqPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL
...| .....|... . . ..  . .||..||. . |   . |. . |..|||..|||.||..| .|...|. ||||||||... |..  ..|| ||.||
dteievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPl

HSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ---RILRHFHFTTWPDFGVPNPPQT
. | .||||| || .|  .||||.  ||.. |. .|||. . .. || . |..... . .|... ...| . |..   | . ||..| ||| .||.  ..
entiedfWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LVRFVRAFRDRIGA-EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
|. ...  |      ...|||||||||||| ||||.|| .|....    .|.| .|  .|  |  |||...||. |.. ||...|  
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1260-1529 2.2e-83 274.6 In-house 5-277 (281) alignment
Range on Protein: 1260-1529
Range on HMM: 5-277/281.0
HYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMC
| . .|....  | ||.|.|...|.|.. | .  . |. |||..||  ||..| |..| .... .||||||.||| ....|.|.||||. .. ..||.| 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML-CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG
|| . .||||.||  |.|. || .|||.|.  . |||..|. .. .. | ..  .|.|  ...|.| ......|.||| |||. .. |. | .. .    
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklte

A-EQRPIVVHCSAGVGRSGTFITLDRILQQINT-SDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
  .. |.|.||||||||.||.|.|||.......    .|.  .|  .|||| .||||  ||  ... .| .|.
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

0040439 (Phosphotyrosine protein) phosphatases II 1287-1526 2.7e-83 274.7 In-house 2-244 (249) alignment
Range on Protein: 1287-1526
Range on HMM: 2-244/249.0
PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP
....| ||.|..|||...||||||||.||..... ..||||||.|..| ...|.||.|||||..| .|||||.|| ....|||||...|.|||||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NdTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLD
.   .. |||..|. |.  ...|.......|     .| |  .|...| |||.|||  ...|..|..| |. . .  .. |..|||||||||.||||...
l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
 .|.|...   ||.. .|  .|. | ..||...||. ....|| 
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_PTPRA_pd Subfamily PTPRA 1249-1534 5.2e-83 273.6 In-house 11-302 (330) alignment
Range on Protein: 1249-1534
Range on HMM: 11-302/330.0
NRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL
  |. .... |  |  |||   .| |||. |     .  .  |.   |. |||. ||||||.||  |....  | |||||| .. |..   .|| .|||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

HSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLC------RGSEQRILRHFHFTTWPDFGVPNP
. | .||||| || .| .|||||   |. .||| ||||.. . | ||.|.|.. ..    |. . .|..       |  ..|..| ||||.|||.|||  
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

PQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV-LEGKENI
|. ....... .     .  ||||||||||||.||||.|| .|.....   ||.|..|  .|. |  ||||..||  |.. ||   | |  ..
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel

0042113 (Phosphotyrosine protein) phosphatases II 1288-1527 8.6e-83 272.7 In-house 1-242 (245) alignment
Range on Protein: 1288-1527
Range on HMM: 1-242/245.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPN
...| ||.|..|||...||||||.|.||.|.. |..||||||.||.|.. .. ||.|||||..| .|||||.|| ....|||||...|.||.||.||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

dTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG-AEQRPIVVHCSAGVGRSGTFITLDRI
   .. |||..|. |.  |..|........   . .|.|  .|.|.. |||.|||. ...|..|... |. .   .. |..|||||||||.||||.....
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|.|...   |... .|. .|. | ..|||..||. ....||  
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0045098 (Phosphotyrosine protein) phosphatases II 1266-1530 3.8e-82 271.1 In-house 3-274 (278) alignment
Range on Protein: 1266-1530
Range on HMM: 3-274/278.0
ADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKlqpvdddegsDYINANYVPGHnsPREFIVTQGPLHSTRDDFWRMCWESNSR
|... ... |||.| . |  . .|.| ...|..|||...|||||||| |          |||||.|..|.  |..||.||||| || .|||||.|| ...
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

AIVMLTRCFEKGREKCDQYWPNdTVPVFYGDIKVQILNDSHYADWVMTEFMLC------RGSEQRILRHFHFTTWPDFGVPNPP--QTLVRFVRAFRDRI
.|||||...|.|||||.||||.   .. |||..| .|. ... |.... ....       . |.| ..|.|...|||.|||. |  . . ....  |...
vivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefireal

GA-------------EQRPIVVHCSAGVGRSGTFITLDRILQQIntSDYVDIFGIVYAMRKERVW-MVQTEQQYICIHQCLLAVLEG
 .             .. |..|||||||||.||.. .. .|...   . ||.. .|  .|. |   .||...||. ....|| .|. 
kllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

Y_phosphatase Protein-tyrosine phosphatase 1296-1525 4.1e-81 267.2 Pfam-A 1-234 (235) alignment
Range on Protein: 1296-1525
Range on HMM: 1-234/235.0
NRPKNRFTNILPYDHSRFKLqpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-NDTVPVFY
|. |||...|||||..| ||   .... ||||||||| |......||.||||| || .|||||.|. ....|||||.. |||||||.|||| ..  .. |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIKVQIL-NDS-HYADWVMTEFMLCRGSEQ---RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN
|||||..  . . . ........ |    |.   |.....|.|.||| |||. |. |....|... .  |.. |.||||||||||.|||..|| .|.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
. . ||.. ||  .||.|  |||...||| .....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1296-1525 4.1e-81 267.2 In-house 1-234 (235) alignment
Range on Protein: 1296-1525
Range on HMM: 1-234/235.0
NRPKNRFTNILPYDHSRFKLqpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-NDTVPVFY
|. |||...|||||..| ||   .... ||||||||| |......||.||||| || .|||||.|. ....|||||.. |||||||.|||| ..  .. |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIKVQIL-NDS-HYADWVMTEFMLCRGSEQ---RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN
|||||..  . . . ........ |    |.   |.....|.|.||| |||. |. |....|... .  |.. |.||||||||||.|||..|| .|.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
. . ||.. ||  .||.|  |||...||| .....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1253-1530 6.8e-81 266.8 In-house 10-292 (298) alignment
Range on Protein: 1253-1530
Range on HMM: 10-292/298.0
LIKNFAEHYRLMSADSDFRFSEEFEELKHVGR---DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLH
|.. . .    . . .  ....||..|..|     ..  . |  | |. |||...|...|.||  |. .|.|| |||||| .. ...    ||.||.||.
lkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt

STRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDtVPVFYGDIKVQILNDSHYADWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLV
.|  ||||| .| .. .|||||   |... |. .|||..     ||.|.|..|.. ..|| ....... . .  ..| .|..|||.||| |||.  ....
etvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvl

RFVRAFRD-RIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
 ..|  |  .  | ..|..|.|||||||||||| .| .|......  ||.| .| ..||.|. .||||.||. |..  | .|. 
dllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds

subfamily_PTPRK_pd Subfamily PTPRK 1258-1534 1.5e-79 262.1 In-house 10-284 (314) alignment
Range on Protein: 1258-1534
Range on HMM: 10-284/314.0
AEHYRLMSADSDFRFSEEFEELKHVgrdqpCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWR
 ..  |. .   . | ||.| |           |    || |||...||.||.|| .|...|.|  ||||||... ... |..||||||||..|  ||||
lqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWr

MCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPvfYGDIKVQILNDSHYADWVMTEFMLCR----GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF
. .. |. .|||||   |.|| || .|||.||    ||||||.... .  |. |.  | ...     .|.|..|.|.|..|||..||.  ..|...||  
lvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

RDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENI
      |. .|||||||| ||.||||..| .|. |.. . ||.| .| ..|...| ||.||.||. |.. .|  .| |.  |
kksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetai

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1251-1535 4.4e-77 254.2 In-house 3-291 (305) alignment
Range on Protein: 1251-1535
Range on HMM: 3-291/305.0
PILIKNFAEHYRLMSADSDFRFSEEFEELKHVgrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHS
.| ....|.. . ....||  . .....| .   ....       |. |||...| ..|..|..|.. .... ||||||.|| |...  ..||.||||..
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP-VFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTL
| .||||. .|   . |||||.  | |..|| ||||. .   . .|...|.. . ....|... .. ..     .|.| . ....|.||| |||. . .|
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

VRFVRAFRDRIGAEQR-PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE-NIV
.....  . .   ..  |..|||||||||.|.||..|  |..... . ||.|... ..|..|. |||| .||  .|. |   ..  . .|.
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsii

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1292-1532 7.2e-77 253.0 In-house 5-246 (250) alignment
Range on Protein: 1292-1532
Range on HMM: 5-246/250.0
DLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREkCDQYWPNDTvP
  | |. |||...|...|.||  |.... |. |||||| .. |..  . ||.|||||..|  ||||| .| .| .|||||   |.... . |||| .. .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.a

VFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ--RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA-EQRPIVVHCSAGVGRSGTFITLDRILQQI
  |||..|..|.. ..||.......| . ...  ||.|..||..||| |||.  .. . ...  .      ...|..|.|||||||||.||..| .|...
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

NTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
...  ||.| .. ..||.|. .|....||. ... .|  |.  |
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_PTPN9_pd Subfamily PTPN9 1273-1526 1.2e-76 252.5 In-house 19-288 (297) alignment
Range on Protein: 1273-1526
Range on HMM: 19-288/297.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTR
|.|..|...       . . |..|  |||.|..| ||..| .|. ||.|| |||||||.| |.. .. || |||||. | .||||| ||.. . ||| ||
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

CFEKGREKCDQYWP-NDTVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR-------IGA---
. |.|| || |||| ..     .||..|. ... .. |.... . .   . .|.| . || |..|||.|||.  ..|. .... |..       .|.   
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewk

---EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
   .. |||||||||.||.|||||||  |..... . ||..  |  .|. | ...||..||   ....| 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_PTPN12_pd Subfamily PTPN12 1271-1529 2.1e-76 251.6 In-house 9-278 (290) alignment
Range on Protein: 1271-1529
Range on HMM: 9-278/290.0
RFSEEFEELKHVGR----DQ--PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNS
.|..||..||.. .    ..  . . .. . |. |||. .|||||.|| .|.  ...|||||||||.. | ... |.| .||||  | |||||| || | 
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

RAIVMLTRCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYA-DWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQR
. .||. | .| |. ||..|||.    .. .|...|.  .. .   |...  . . . .|.|... ||.| ||| |||. ...|.......|..  .|. 
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqeseda

PIVVHCSAGVGRSGTFITLDRILQQINTS---DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|.|||||||||| || |..| . .....    . .|.| .|  .||.|. .|||..||  ...... ...
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

0037934 (Phosphotyrosine protein) phosphatases II 1288-1525 3.1e-76 251.4 In-house 2-239 (243) alignment
Range on Protein: 1288-1525
Range on HMM: 2-239/243.0
CTFADLPCNRPKNRFTNILPYDHSRFKLqpvdddEGSDYINANYVPGHnsPReFIVTQGPLHSTRDD----FWRMCWESNSRAIVMLTRCFEKGREKCDQ
...| ||.|..|||...|||||||| ||      |||||||||....   || .|.||||| .| .|    ||||.|| ....|||||...|.|||||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPnDTVpvFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA--------EQRPIVVHCSAGV
||| ..|   |||..|..|. .|..|.......|..   . ..|  .|.|.. |||.|||. |. |..|... |. | .        ...|..|||||||
ywp.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRSGTFITLDRILQQIntsDyVDIFGIVYAMRKERVW-MVQTEQQYICIHQCLL
||.||.|... .|...   . ||.. .|  .|. |   .|||..||. ....||
gRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Ptp69D_pd Subfamily Ptp69D 1251-1528 3.8e-76 251.2 In-house 3-286 (307) alignment
Range on Protein: 1251-1528
Range on HMM: 3-286/307.0
PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHS
.| |.. .| ..    |.|| . .|.|.|..   |. .....   |  |||. .| ..|. | ||...  .| ||||||... |..  ..||. |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDtVPVFYGDIKVQILNDSHYADWVMTEFMLCRGS-------EQRILRHFHFTTWPDFGVPNPP
| .||||| .| ..  ||||.   || |.||..|||..   | |||| |.. . ..  |... |. . .         ..| .  .|.|.|.|. ||. .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

QTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..|.....  |.    .. ||||||||||||||.|..|| .|||... | |||| .|  .|..|  .||  .||. ... ||   
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_PTPN6_pd Subfamily PTPN6 1270-1532 5.7e-75 247.2 In-house 26-301 (306) alignment
Range on Protein: 1270-1532
Range on HMM: 26-301/306.0
FRFSEEFEELKHVGRDQPC--TFADLPCNRPKNRFTNILPYDHSRFKLQpVDDDEGSDYINANYVP--GHNSPREFIVTQGPLHSTRDDFWRMCWESNSR
  |.||||||..    .    . .. | |. |||. ||||.||.| .|.  ..  |||||||||.    ..| ...| ||| |..|  ||||| |. |||
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

AIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLC---RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG----
 |||.|.  |.|.||| .|||. .    ||.|.|. ..... ||... |....   ...|.| ....||..||| |||. |.... |..  . .      
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
||..|||||||||.|| |||| .| .|..|... .   .||  .|  .|. |  .|||||||  ... . . .| |.
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1252-1535 5.3e-73 241.1 In-house 11-299 (319) alignment
Range on Protein: 1252-1535
Range on HMM: 11-299/319.0
ILIKNFAEHYRLMSADSDF-----RFSEEFEELKHVGRDQ-PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQ
. ...|  .|. .|  |||     ..  ||  . ..| .    |||.|. |. |||..|||..|... ||....  |.|||||| .| |. ..  .| .|
vavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaq

GPLHSTRDDFWRMCWESNSRAIVMLTrcfekgREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNP
|||  | .||||| ||.|. .||.||      ..|| ||||...| . ..  ||..      |..|. .. | .     ..| .. |||  ||| |||. 
GPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy

PQTLVRFVRAFRDRIG--AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENIV
|  |.|.|.  |       ....|||||||||||.|..|.|| .|....  . ||.. .|  .|..|  .||   ||  |.  ||   | |. ...
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1272-1530 2e-72 238.9 In-house 20-278 (515) alignment
Range on Protein: 1272-1530
Range on HMM: 20-278/515.0
FSEEFEELKHVgRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
||||| .|       | | |.   | .|||. |||||| .| ||. ..|.  |||.|| |.|. .. . .| .|||.... |||||. .. |  .|.|.|
fseefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

RCFEKGREKCDQYWPN-DTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSA
.  |  . || .|||.  .  | .| |||...  .  .. .  .. . .|.. | .  |||| ||| |||.  ..|...... .   |  . |...||||
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsa

GVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
|||| | .|..| .. ...|.. ||.| .|  .|..|. .|||..||  |.. .|  |  
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1288-1536 2.9e-71 235.3 In-house 17-264 (284) alignment
Range on Protein: 1288-1536
Range on HMM: 17-264/284.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTrcfekgREKCDQYWPN
 |||.|. |. |||...||..|... ||....  |.|||||| .. |. ..  .| |||||  | .||||| ||.|. .||.||      ..|| ||||.
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

DTVpVFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRI--GAEQRPIVVHCSAGVGRSGTFITLD
..| . ..  ||..   .  ...|. .. | .     ..| .| |||  ||| |||. |  |.|.|.  |       ....|||||||||||.|..|.||
kiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENIVG
 .|....  . ||.. .|  .|..|  .||   ||  |.  ||   | |. ... 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdval

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1271-1531 3.4e-71 234.6 In-house 20-280 (315) alignment
Range on Protein: 1271-1531
Range on HMM: 20-280/315.0
RFSEEFEELKHVGrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 ||||| .|       . . |  . | .|||. ||||.|..| ||. .||.  |||||| |... .. . .| .||||... |||||| ....  .|||.
lfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TRCFEKGREKCDQYWPN-DTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCS
|   |  . || ||||. ..  | .| |||..|. .  .| |. .... .. |.| .  |.|| ||| ||..   .|...... .   | .. ...||||
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcs

AGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
|||||.| .|..| ...||. .. ||.| .|  .|..|. .||||..|  |.. .|  |  .
aGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr

subfamily_PTPN3_pd Subfamily PTPN3 1275-1529 9.1e-70 229.8 In-house 20-276 (280) alignment
Range on Protein: 1275-1529
Range on HMM: 20-276/280.0
EFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvdDDEGsDYINANYV----PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
.||.|    ..  .. | .| | .|||. .|||||. | ||.   . |  ||||||||    |...    .|.|||||..|  |||.| || .|. ||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHC
|   |.|| || ||||. .  . ||...|.. ....   .|. |..|.. .  |.| . .. .. ||| |||. .. ...||.  |.   ....|.||||
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|||.||.| .|.|.  |. |.... | .  ||  ||  |  .|||..||  . ...|.| |
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye

subfamily_PTPN1_pd Subfamily PTPN1 1270-1537 2e-69 228.5 In-house 6-277 (290) alignment
Range on Protein: 1270-1537
Range on HMM: 6-277/290.0
FRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDdegsDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM
 ...| ......  .| |.. |.|| ||..||. .. |||||| ||.  |     |||||. |  ..  |..|.||||| .| | ||.| || .|.|.||
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTRCFEKGREKCDQYWPNDT--VPVFYG--DIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR--IGAEQ
| .. ||.. || ||||..     . .    .||....  ..  ...  . |      | | . |||.|||||||||. |.....|.   |.   .  ..
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdv

RPIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIVYAMRKERVWMVQTEQQyicIHQCLLAVLEGKENIVGP
 | |.|||||.||||||. .| .| .|. .|    |||   . ..|| |. ..|| .|   ..   ||.|||   | |.
GpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadq...lrfsylaileGakvikgd

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1270-1527 2e-69 228.9 In-house 24-278 (315) alignment
Range on Protein: 1270-1527
Range on HMM: 24-278/315.0
FRFSEEFEELKhVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM
  | ...| .   |. .|   |    |. |||. ||..||.|| .|  .. |..|||.|||...|.| .| .| .|||. .. .||||. .| .   |||
ngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivm

LTRCFEKGREKCDQYWPNDtvPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCS
||   |. ..|...|||..   | || | |   .. .. .. .  .    |.. | .  .|.|.||| |||.   .|. ..|  .    ..  .||||||
ltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcs

AGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|||||.||||||| .|.|... . .|.. ..  .|. |. |||. .||  |.. ||  
aGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1254-1529 2.5e-68 225.1 In-house 4-284 (290) alignment
Range on Protein: 1254-1529
Range on HMM: 4-284/290.0
IKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEG--SDYINANYVPGHNSPREFIVTQGPLHST
...|.|.     |  . .| ..|. |.   ...  | .  . |...|||.||..||  |  |.|. ...    .|||| |. |..  ...|.||||...|
vdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt

RDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVfYGDIKVQILNDSHYADWVMTEFMLCRGSE---QRILRHFHFTTWPDFG-VPNPPQTLV
  |||.. |. .. .|||||   |.|..|| ||||.  .   || .....||.... . . ... .   ..   .... ....|.|.. | |.||   |.
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

RFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
 . .  . .    ...||||||..||||..|....  ... .|   .|.| ... .|  .  .|||.|||  |.| .|  |.
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1248-1532 9.1e-68 223.5 In-house 6-288 (297) alignment
Range on Protein: 1248-1532
Range on HMM: 6-288/297.0
QNRPILIKNFAEHYRlMSADSDFrFSEEFEELkHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSprEFIVTQGP
. ||| . .||   .  . ..|. |||||  |      || | |.   | .|.|..|||||| || ||. |.||  |||.|| .|.| .   ..| || |
errpiplsdfatlvq.knrhtdv.fseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmP

LHSTRDDFWRMCWESNSRAIVMLTRCfEKGREKCDQYWPNDTVPVfYGDIKVQILNDSHYADWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPN--PP
 ..| .|||.| .. .  .||||.   ... .|| .||....|   .||. |..|  |.    .  |. . .|.   .|... ..|. |||  |..    
mkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

QTLVRFVRAFRDRIGAEQR-PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
..|. ..   |.  . ..  |..|||.||||| | ..|.| .. ...  . |||||.|  .|.||. .|||..||  ... .| .|  ..
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1294-1526 2.3e-66 218.6 In-house 18-262 (270) alignment
Range on Protein: 1294-1526
Range on HMM: 18-262/270.0
PCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPG-HNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND---T
  ..  ||...|||  ..| .|.....|. . |||||||.| .......| ..||| .|  .|||| ||....||||.|   ||||.||..|||..   .
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

VPVFYGDIKVQILNDSHYADWVMTEFMLC-RGSEQRILrHFHFTTWPDFGVPNPPQ------TLVRFVRAFRDRIGAE-Q-RPIVVHCSAGVGRSGTFIT
| . .|.|||  |....   ...|.  |  .|.|.|.. ||...|||| |||. ..       |.. .|| |       .  |..|||||||||.||.|.
vkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

LDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
|| ... ....  ||.  |. ..||.|. .||. .||  ... .. 
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1291-1525 7.4e-66 217.0 In-house 23-265 (274) alignment
Range on Protein: 1291-1525
Range on HMM: 23-265/274.0
ADLPCNRPKNRFTNILPYDHSRFKLQP-VDDDEGSDYINANYVPGHNS-PREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND
 |.. .  |||...||| ..||  |..   .|| |.||||||. | .   . .. ||||| .| .||||| .. ... |||||.  |. ..|| .|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

TV---PVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR---IGAEQRPIVVHCSAGVGRSGTFITLD
.       |||..... .  .  |. .....|   ...| . |. .| |||  .|. ..||...|.  ..      |.  |.|||||||.|| | ||. .
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
  ..|.. .  ||...||  .| .|  ||||..||  ||. | 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_PTPN13_pd Subfamily PTPN13 1273-1529 7.8e-66 217.1 In-house 14-270 (273) alignment
Range on Protein: 1273-1529
Range on HMM: 14-270/273.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvddDEGSdYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
.|||.||...   . |. .    |. |||. |.||||..| ||.    |||. ||||...  |  .   |.|..||||  | .|||.| || ... |.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TRCFEKGREKCDQYWPNDTV-PVF-YGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRdRIGAEQRPIVV
|   |||. ||..|||. .  ..  .. ..|. |.  .. ..|. ....   . .| | . |..|..||| |||. .. |..||.  | |.  .. ||||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr.rlqtdagPivv

HCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
|||||.|||||.||.| .|. |.    .|.  ||  .|. |  .|||..||| ... .| ||.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1254-1532 1.9e-65 215.7 In-house 4-282 (287) alignment
Range on Protein: 1254-1532
Range on HMM: 4-282/287.0
IKNFAEHYRLMSADSDFRFSEEFEELKHVGR-DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvddDEGSDYINANYVPGHNSPREFIVTQGPLHSTR
...|.|  .   | ..  |.. |  |..|.. ..  | .  . |..|||.|.||..|  |  |.    .|  ||||| .. |... ..||....|. .| 
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnta

DDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLCRG---SEQRILRHFHFTTWPDFG-VPNPPQTLVR
 .||.. .. |  |||||..  |. .|.| ||||...  | .|. ....||. ..|.... .. . .    .... .. ...|.|.. | |..|   |. 
rnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

FVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE
. . .. .    . .||||||..||||..|.  .  ... .|   .|.| ..  .|  .  .||| .||. | . .|. |.  |
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1252-1528 4e-65 215.1 In-house 5-288 (325) alignment
Range on Protein: 1252-1528
Range on HMM: 5-288/325.0
ILIKNFAEHYRLMSADSDFRFSEEFEELKHVGrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHST
| . |. ||     |. .  |. ||. |  ..  .  . | .| |. |||| |....|.||  |.  .||  ||||||.|.  .     |. .| || .|
iavvnlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat

RDDFWRMC--WEsnsRAIVMLTRCFEKGREKCDQYWPND-TVPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTL
 .|.||.   |.    ..|...  ...| ..| .|||..    . .| ..|..    ...|.|.  . .   .. | | .. |.. .|.|.||.. | ||
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatl

VR---FVRAFRDRIGA---EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
.     | |  .|. |      ||.|||||||||.|.||.|  .|... .   ||||| |  .||.|  ||.|  ||| |...|  ..
isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPN23_pd Subfamily PTPN23 1273-1530 4.5e-61 201.2 In-house 22-279 (288) alignment
Range on Protein: 1273-1530
Range on HMM: 22-279/288.0
SEEFEELKHVGRDQPCTFADlpCNRPKNRFTNILPYDHSRFKLQpvddDEGSDYINANYVPGHN--SPrEFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 |  .. ..  |.. .. |   ..  |||...||||||.| ||.    ..  ||||| .| .    .| .||.||.||.||  |||.| .|  |. ||||
keleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVml

TRCFEKGREKCDQYWPNDT-VPVFYGDIKVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRD----RIGAEQRP
.   |.|..|.|.|||.|.  .| .||..| . .  .   .|  .. |   . .. . ..| ..|.||..|||. |.||..|. . ..    .    . |
lskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktP

IVVHCSAGVGRSGTFITLDRILQQINTSDY-VDIFGIVYAMRKERVWMVQTEQQYiciHQCLLAVLEG
.||||||||||.|.|  .  ....... .  .||  .|  .|..| .|||...|.   .... |||| 
lvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql...kfsyeavlea

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1296-1525 1.3e-59 196.4 In-house 3-236 (237) alignment
Range on Protein: 1296-1525
Range on HMM: 3-236/237.0
NRPKNRFTNILPYDHSRFKLQPVDDDegSDYINANYVPGHN-SPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFY
|. |||. ||  |||||  |.    .  ||||||.|. | . .|...| .|||| |. ||||.| |. .   |||||   |. ..|| .|||.   |  |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDIKVQILNDSHYADWVMTEFMLCRGS---EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLDRILQQIN
| . | .  . ...|. .  ..| .     | |..  ..||.||| |||.   .|.|| .   .|     |  | ..||||||||.| |. .| .|.| .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
    |||.  ||.. ..| ...||..||. ||| .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1295-1527 9.3e-58 190.2 In-house 6-236 (239) alignment
Range on Protein: 1295-1527
Range on HMM: 6-236/239.0
CNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGH-NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpvF
 |. |||..||. |||||  |. . .|  ||||||.|.  .  ||. .| ||| .  .  ||||| |.     |||||   |  ..|| ||||. |    
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..k

YGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS
| ...| . .   .||...  |.. .   .|.| . ..||| ||| |||.   ... . |          || |.||||||||.|.|. .| .|.| .  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DYVDIFGIVYAMRKERVWMVQTEQQYICIHqclLAV
  ||||  | |.|..|  |||| .||. ||   |||
ktvdifnyvkairedrphmvqtseqyvfih...lav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1295-1525 1.2e-57 189.8 In-house 7-238 (239) alignment
Range on Protein: 1295-1525
Range on HMM: 7-238/239.0
CNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGH-NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpvF
 |. |||..||. |||||  |. . .|  ||||||.|.  .  ||. .| ||| .  .  ||||| |.     |||||   |  ..|| ||||. |    
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..k

YGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS
| ...| . .   .||...  |.. .   .|.| . ..||| ||| |||.   ... . |          || |.||||||||.|.|. .| .|.| .  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
  ||||  | |.|..|  |||| .||. || ..|
ktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_CG7180_pd Subfamily CG7180 1287-1525 2.4e-57 188.8 In-house 33-287 (296) alignment
Range on Protein: 1287-1525
Range on HMM: 33-287/296.0
PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGReKCDQYWP
 |  .    || |||  ...|||. |  |. .| .| |||||| || ..  ..|.|||..| ..| |.|||. .. .. |.|.||. |.  . .. .|||
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

NDTvPVFYGDIKVQILNDSHYADWVMTEFMLCRG------------SEQRILRHFHFTTWPD-FGVPNPPQTLV---RFVRAFRDRI--GAEQRPIVVHC
|..    ||.| |.|..  .||. .. .| | .              |.||...|..|.|.    ||   ..|.   | || .|...    |. |.||..
nks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
| |..||| ....|  |....  . ||.|. |  .|..|  .|.. ..|  | . ||
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1275-1525 7.8e-56 184.0 In-house 11-263 (283) alignment
Range on Protein: 1275-1525
Range on HMM: 11-263/283.0
EFEELKHVG-RDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDdegsDYINANYVP---GHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 .| ||...  |.... |    |..|||. .|.|.|  | .|..       ||||| ..|    ..  ...|..|.||. |. |||.| .. .  |||||
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TRCFEKGREKCDQYWPNDTVpVFYGDIKVQILNDSHYADWVMTEFMLCRG---SEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVH
|.  |  |.|| ||||..   . ||.  | . ..     ... |..|       .. .| |. .  | ..|   .  .||.| .    .   .. |||||
tklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvh

CSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL
||.|.||...||..   .... |.  ||.| .|  ||..|. .||| .||  .|.  |
CstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1256-1528 1.4e-55 183.6 In-house 6-279 (439) alignment
Range on Protein: 1256-1528
Range on HMM: 6-279/439.0
NFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCT--FADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRD
.| ||   .  . .  |.|.||... .  |  |   .|    ...|||. .. ..||.|  || .     | ||||||. |.  .. .| |||| . | |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMCWESNSRAIVMLTRCFEKGRekcdqYWPNDTvPVFYGDIKVQILNDSHYADWVMTEFMLC----RGSEQRILRHFHFTTWPDFGVPNPPQTLVRF
||||. .| ..  |||||  .|  .     ||| |.  |.|||| |..  .    ..|.  | .     ..  .| . .||...|||  ||     .. |
dfwrlviekktvtivmltnlvesyk.....ywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

VRAFRDRIG-AEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
.||        |  |.||||||||||.|| |.||  |.|... . ||| |||  .||.|  |||.  ||. |....|  .
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

0051429 (Phosphotyrosine protein) phosphatases II 1323-1529 5.4e-55 182.2 In-house 3-226 (272) alignment
Range on Protein: 1323-1529
Range on HMM: 3-226/272.0
GSDYINANYVPGHNS---PREFIVTQGPLHSTRDDFWRMcWESNSRAIVMLTRCFEKGREKCDQYWP-----------NDTVPVFYGDIKVQILNDSHYA
 |.||||..|.| ..   |. .. ..|||. | .||||. .| . ..||.|....|.||.|||.|||           ... ...||.. | .|  ... 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DWVMTEFMLC---RGSEQRILRHFHFTTWPDFGVPNPPqtLVRFVRAFRDrigaeQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVD--------IF
|....|..|      .| | ..|.|.| |||.|||  .  |........|     ..|..||||||..|.||.. |...|.... .. ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

GIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
..|  .|. | ..||||.||......||..|.
eaveelraqrpgavqteeqylflyeallellr

subfamily_PTPN14_pd Subfamily PTPN14 1273-1528 3.7e-54 178.8 In-house 26-296 (300) alignment
Range on Protein: 1273-1528
Range on HMM: 26-296/300.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDeGSDYINANYVPG--HNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
  |.|....   |  .. | || | .|||| ..|||...| .|.|  ..  ..||||  .      . |..||.||||. |  |||.| ||.. . ||||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TRCFEKGREKCDQYWPND---TVPVFYGDIKVQ--ILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF---RDRIGAEQ-
|.  |.|.||. .|.|..      | .|  ||.    .||.       ..     .|.| . |. .| ||| |||. ... . ... .   | .   |. 
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

-----RPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
      |..|||||||||.|  |. | ... ... . .||  ..  .|. |  .|||  ||  ... |.  |
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1271-1529 4.1e-54 178.5 In-house 21-237 (392) alignment
Range on Protein: 1271-1529
Range on HMM: 21-237/392.0
RFSEEFEELKHVGrDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 |.||| .|       | | |  . | .|||. |||||| .| ||. .||   |||.|| |.|. .. . .| .|||  .. |||||| .. |  .|.|.
lffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TRCFEKGrekcdqywpndtvpvfygdikvqilndshyadwvmtefmlcRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSA
|.  |                                           .| ..|    |||| ||| .||.   .|..|..  .   |   .|...||||
tklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsa

GVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
||||.|  |..| .. . ...  ||.| .|  .|..| .||||..||  |. ..|  | 
gvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1273-1524 4.8e-54 178.1 In-house 13-273 (287) alignment
Range on Protein: 1273-1524
Range on HMM: 13-273/287.0
SEEFEELKHVGRDQPCTF--ADLPCNRPKNRFTNILPYDHSRFKLQpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
 .|.. ||.  .  . ||  |.   .  |||....||.|..|  |   . . ||||||||||....   .||..|||. .|  ||||. .| .| .....
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

TRCFEKGREKCDQYWPNDTVPVFYGDIKVQILN-DSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF-----RDRIGAEQR
||  |..| || .|||.  ||.  |   | .|. |    .. .  . |    . | |... ... .||| ...     |.|||          | ..|  
treveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCL
|.|||...|.||||.....  .... .    ||.  .|  .|. |  .||.  |.  . . |
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

0041856 (Phosphotyrosine protein) phosphatases II 1296-1533 3.4e-51 168.7 In-house 1-176 (182) alignment
Range on Protein: 1296-1533
Range on HMM: 1-176/182.0
NRPKNRFTNILPYDHSRfklqpvdddeGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTrcfekgrekCDQYWPndtvpvfyg
|..|||...||||||||          ..||||||.. |   ...||.||||| ||  ||.|| .| . ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dikvqilndshyadwvmtefmlcrGSEQRILRHFHFTTWPDFGVPNpPQTLVRFVRAFRDrigaEQRPIVVHCSAGVGRSGTFITLDRILQQintsdYVD
                          ..|   ..... |||.|||. ...|..|... ..    |..|..|||||||||.||.. .. ....      |.
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
.. .|  .|. |  ||.|..||. ....|| .|..|..
leeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1268-1529 7.7e-50 164.3 In-house 14-294 (301) alignment
Range on Protein: 1268-1529
Range on HMM: 14-294/301.0
SDFrFSEEFEELKHvGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVD--DDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSR
|.  |.|...|||. |.|..||      |.. ||| || .||. |. |.|    |    .||||.|. | .. ..||..|||...|  ||||. |.    
snk.feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLTRCFEKGREKCDQYWPN-DTVPVFYGDIKVQILNDSHYADWVMTEFM--LCRGSE-QRIL--------------RHFHFTTWPDFGVPNPPQTLV
.|||.|   |. ..|| ||||| ..    .| ..|.. |.  | |.|. ..   .  ||. ..|                 .. | ||. ||   |.| .
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

RFVRAF-RDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
. .      .   .  |.|||||..|.|||......  | |      ||.|... |.|. .  .|.| .||. |.. .   |.
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1272-1526 4.4e-49 161.6 In-house 13-267 (281) alignment
Range on Protein: 1272-1526
Range on HMM: 13-267/281.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQP-VDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML
| .|| .|      . ||  . | |  |||..||   | || .|.  . . . .||| |||.      | .|.|||| . || ||||| |. |. |||||
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TRCFEKGREKCDQYWPNDTVPV-FYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRigaeQRPIVVHCS
 .  |  |||| .|.| ..  .  .  . |.  . .     | | . |    | |.. |. .  |||. ||.  . ... .|  | |      | |.|||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcs

AGVGRSGTFITLDRILQQINTS-DYVDIFGIVYAMRK-ERVWMVQTEQQYICIHQCLLA
||||||||.....  || | .     ||  ||  .|   |   ||| |||. | . || 
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_PTPRN_pd Subfamily PTPRN 1271-1523 1e-48 160.6 In-house 30-287 (297) alignment
Range on Protein: 1271-1523
Range on HMM: 30-287/297.0
RFSEEFEELKHVGRDQPCT-FADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNsPRE--FIVTQGPLHSTRDDFWRMCWESNSRAI
|...|.| |..   .. ..  |. . |  ||| ...||||||| ||.   ..| ||||||  .  |. ||.  .| ||||| ||  |||.| ||. .  |
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd.prapayiatqgplastvadfwqmvweqGvvvi

VMLTRCFEKGREKCDQYWPNDTVPVfYGDIKVQILNDSHYA-DWVMTEFML--CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPI
|.|||  |.| ..|..|||..   | |.  .|... .  .. |...  | |   . || | .  ||| .||. |||  ...|. | |           ||
vnltrleeegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpi

VVHCSAGVGRSGTFITLDRILQQINT-SDYVDIFGIVYAMRKERVWMVQTEQQYICIHQC
|||||.|.||.|..| .| .|....     .||   .  .| .|  .|.|..|.  . ..
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta

0036282 (Phosphotyrosine protein) phosphatases II 1323-1522 8.5e-48 157.6 In-house 1-164 (174) alignment
Range on Protein: 1323-1522
Range on HMM: 1-164/174.0
GSDYINANYVPGHNSPREFIVTQGPLHstrddFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdtvpvfygdikvqilndshyadwvmtefmlCRGSE
|||||||... ..  ....|..||||      ||.|..| .....|||....|.|..|| .|||                                | ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

QRILRHFHFTTWPDFGVPNPPQtLVRFVRAFRDRIGA-EQRPIVVHCSAGVGRSGTFITLDRILQQINtSDYVDIFGIVYAMRKERVWMVQTEQQYICIH
 |   ..... |||.|||. .. | .||.. .. .   ...|..|||||||||.||.. ....|...  ...||.. .|...|. | .||||..||. ..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y

0049772 (Phosphotyrosine protein) phosphatases II 1284-1536 1.3e-46 155.1 In-house 34-288 (314) alignment
Range on Protein: 1284-1536
Range on HMM: 34-288/314.0
RDQPCTFADLPCNRPKNRFTNILPYDhSRFKLqPVDDDEGSDYINANYVPGHnspREFIVTQGPLHSTRDDF----------WRMC--WESNSRAIVM--
... ...|||..|| |||...|||.| .| .| |  . .|||||||.|| |.   . ||.|||||  | .||          |||   .. |.| |||  
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LTRCFEKGrekcdqywpN---------DTvpvfygdikvqilndshY-------AdwvmtefmlcrgsEQRIlRHFHFTTW
                   |... ..|         |                                                  |...  ... . .
devladelsrLdaAlgKtpllildgng.........neptaadlellk.................eelydpelf.............erlg.ikylripv

PDFGVPnPPQTLVRFVRAFRDRigAEQRPIVVHCSAGVGRSGTFITLDRILQQINtsdyVDIFGIVYAMRKERV-----WMVQTEQQYICIHQCLLAVLE
||...| ... . .|......    ...|..|||.||.||.|||.... .. . .    |..  ..  .|. |       .... .||. |...||  |.
pDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk

GKENIVG
 ...  .
flkkfye

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1275-1526 3.2e-46 152.7 In-house 21-275 (307) alignment
Range on Protein: 1275-1526
Range on HMM: 21-275/307.0
EFEELKHVGRDqPCTFADLPCNRPKNRFTNILPYDHSRFKLQpvDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCF
||..| .   .   |   . .|  |||....   |..|  ..   |   |||| |||.     |. ||..||||..|. .|| |. . .  ...|| .. 
efrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EKGREKCDQYWPNDT-VPVFYGD----IKVQILNDSHYA---DW-VMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRdrigAEQRPIV
| .. ||.|||| .      .|.    | |. |   . |   |   .|.. .  ... | ..|. .. ||| |||.   | . .. | |     .. |.|
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvv

VHCSAGVGRSGTFITLDRILQQ-INTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
|||||||||||| ...  . .. |.  .  |.  .|  .|..| . .||| ||. .|. || 
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1298-1526 3.8e-45 148.8 In-house 58-281 (290) alignment
Range on Protein: 1298-1526
Range on HMM: 58-281/290.0
PKNRFTNILPYDHSRFKLQpvdDDEGSDYINANYVPGHNSPreFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPV-FYGD
 |||. ..   | .|  |.   |    ||. |||| | ...  ||.|||.|..|  |.|||  . .  |||||   .|.|. ||.||.|.    |  .|.
kknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

IKVQILNDSHYADWVMTEF---MLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGaeqrPIVVHCSAGVGRSGTFITLDRILQQINTSDY
| |   ....  . ..      .      . .|.|..  .|||  |..   .|.| .|. |   |    |.|||||||.||.|||....  || .     
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldGke

VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
.|. ..| |.|. |.  || . ||. . . || 
ldlldlvralrnsrlnsvqvdiqylalveilld

0043147 (Phosphotyrosine protein) phosphatases II 1321-1522 2.5e-43 143.1 In-house 2-155 (172) alignment
Range on Protein: 1321-1522
Range on HMM: 2-155/172.0
DEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfekgrekcdqywpndtvpvfygdikvqilndshyadwvmtefMLCRG
|||||||||.|....  |..||.||||| .| .|||||..| . ..||.||..                                          .. . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

SEQRILRHFHFTTWPDFGVPnPPQTLVRFVRAFRD-RIGAEQRPIVVHCSAGVGRSGTFITLDRILqqintsDYVDIFGIVYAMRKERVWMVQTEQQYIC
 ..|   ..... |||.||| ... | .|..  ..  .  .. |..|||||||||.||.. .. .|        .... .|  .|. | ..||...||..
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IHQ
...
lyy

0046846 (Phosphotyrosine protein) phosphatases II 1316-1528 3.7e-43 142.6 In-house 4-173 (176) alignment
Range on Protein: 1316-1528
Range on HMM: 4-173/176.0
QPVDDDEGSDYINANYVPGHnsprEFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNdtvpV----Fygdikvqilndshyadwv
..  .|...||||||.. |.     .|.|||||..|  ||..| .| . .|.|.|| ..|.|| ||..|||     .    .                  
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..................

mtefmlcrgseqrilrHFHFTTWPDFGVPNPpQTLVRFVRAFRDRIGAEqRPIVVHCSAGVGRSGTFITLDRILQqintSDYVDIFGIVYAMRKERV-WM
                ..... |||.|||.  . | ..... |... .  .|..||||||.||.||.. .. .      .  .... ... .|. |  ..
................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplga

VQTEQQYICIHQCLLAVL
|||..||  .....| .|
vqtpeQyrflyefellll

subfamily_ptpA1_pd Subfamily ptpA1 1273-1485 6.8e-42 138.7 In-house 24-253 (418) alignment
Range on Protein: 1273-1485
Range on HMM: 24-253/418.0
SEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHnSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTR
 |||  |.        .  |   |  |||.||||| .|.| .|. ..| ||||||||||. |   |..||.|||||  |  ||||| ||   | ||||.|
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsr

CFEKGREKCDQYWPNDTVP---VFY-------GDIK---VQILNDSHyADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR---
  |. | |||.|||..        |       |      |....|    . .  .  |    | | . ....  |||. .|.  | . .....  .|   
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe.reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnq

-IGAEQ--RPIVVHCSAGVGRSGTFITLDRIL
 | . .   ||.|||||||||.||| |   ..
iipssdrnvpiivhcsagvgrtgtfctavimm

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1267-1526 8.2e-42 138.0 In-house 3-257 (267) alignment
Range on Protein: 1267-1526
Range on HMM: 3-257/267.0
DSDFRFSEEFEELKHVGRDQPCTFADLP-CNRPKNRFTNILPYDHSRFKLQPVDDDegsdYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSR
|..  . .|||..|..  ..      ..  |. .||. . ||||..|  |.  ...    |||| || |..  . |||||.||. |  ||. .  . .  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

AIVMLTRCFEkgrEKCDQYWPND-TVPVFYGDIKVQILNDSHYADWVMTEFMLC-RGSEQRILRHFHFTTWpDFGVPNPPQTLVRFVRAFRDRIGAEQRP
 ||.||. |.   ..  ..||        | |. |.   .    |. .  . |  .    . .  ...  | .  . | |     |    ....   .||
vivlltkvft...dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw.nintnnkpylkplfgilaknqlengnrP

IVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA
.||.||.||||||||...|  |... | . .|||  .  .|. |. .|.| ..|| ||. |  
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1296-1534 1.2e-40 134.2 In-house 48-293 (305) alignment
Range on Protein: 1296-1534
Range on HMM: 48-293/305.0
NRPKNRFTNILPYDHSRFKLQPVDddeGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFY-
.. |||. ..   |. | ||..       .|| ||||     |. || || ||. |  ||| ||.. .  || ||    ||| .|| .|.. .  .|.  
eagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

--GDIKVQILNDS---------HYADWVMTEFML-CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGaeqrPIVVHCSAGVGRSGTFITLD
  .. |...  .|           |.   |....   |...|   |.|.  ||| |||   .... ..   |   |    |||||||||.||.|. . |.
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmle

RILQQINTSDYVD-IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENI
 ||.|. . . ..    |.  .|..|   .||..||. .|| .|  .. |. .
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll

0049260 (Phosphotyrosine protein) phosphatases II 1331-1522 2.4e-40 133.0 In-house 1-144 (152) alignment
Range on Protein: 1331-1522
Range on HMM: 1-144/152.0
YVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWpndtvpvfygdikvqilndshyadwvmtefmlcrgseqrilrHFH
...|.. |.||| ||||.  | .||||| .| . ..|||||...|.|..||.||.                                          ...
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILqqintsDYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
.. |||.|||. .| |  .... . ..  .. |..|||||||||.||.. .. .|        |... .|  .|. |  .|....|.. ...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1296-1529 2.8e-40 133.2 In-house 43-272 (288) alignment
Range on Protein: 1296-1529
Range on HMM: 43-272/288.0
NRPKNRFTNILPYDHSRFKLQpvddDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP----
|  ..|..|.   | .| ||.    |.   ||.|| |. .. .| .| .| ||..| . .|.|  ||. . ||||..  |||.|| ..|.|         
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

-VFYGDIKVQIlNDSHyADWVMTEFMLCRGSE-QRILRHFHFTTWPDFGVPNPPQTLVRFVRAFrdriGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN
  .  ..|..  .| .    ... .   .  | . |... |.  |.| |||.  .. .|..  .     . |.|||||.||||||.||.|    .|... 
grlctvvkkkr.adid.klvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslr

TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE
 .|.. |  ..  .|.||   .|||.||. .|.|.|  | 
lddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1296-1527 9.4e-39 127.8 In-house 55-288 (305) alignment
Range on Protein: 1296-1527
Range on HMM: 55-288/305.0
NRPKNRFTNILPYDHSRFKLqpvDDDEGSDYINANYVPGHNSP-REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTV--PV
.  |||....   |.|  ||   |.   |||| ||||     | . ||..||||  | |.|| |  . .   |||| .  | |. || ||||        
aitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

FYGDIKVQILNDSHY----ADWVMTEFMLCR-GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRdrigAEQRPIVVHCSAGVGRSGTFITLDRILQQ
. . | |. .  |.     |.  .| . |.  |...  .||...| ||| |||    | . .. | |      . |||||||||.||.|| .... ||..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair....gskvpivvhcsagigrtgtivaieyilek

INTSDY-VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
|        .  .| |.| .| . .|.. ||. ||. .|  
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1294-1449 1.2e-36 121.1 In-house 31-189 (297) alignment
Range on Protein: 1294-1449
Range on HMM: 31-189/297.0
PCNRPKNRFTNILPYDHSRFKLQPVDddEGSDYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND-TV
.    |||...|| .| .| ||. |    ..|||||.||  |  ...  .|..||||..| ||||.. .| . |.|||...  | ||.||  |||.    
nsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

PVFYGDIKVQILND--SHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRF
    ||. |. | .   ..   ..||. |   ||.| .||  | .||| |||.  . ||||
rlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf

0051082 (Phosphotyrosine protein) phosphatases II 1323-1524 1.5e-36 120.6 In-house 2-149 (151) alignment
Range on Protein: 1323-1524
Range on HMM: 2-149/151.0
GSDYINANYVPGHnspreFIVTQGPLHstrdDFWRMCWESNSRAIVMLTRCFEKGreKCDQYWPNDTvpvfygdikvqilndshyadwvmtefmlcrgse
 |||||..|| |.     .....|||.    ||... .| . ..||.|.  .| |  .| .|.|.                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDrigAEQRPIVVHCSAGVGRSGTFITLDRILQQintsdyVDIFGIVYAMRKERVWMVQTEQQYICIHQ
 . ..|.... |||.|.|  ......|.....|    .. |..||||||.||.||.. |...|..      |... ..  .|. |  .||..||......
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

CL
.|
al

0044763 (Phosphotyrosine protein) phosphatases II 1307-1525 1.7e-36 120.9 In-house 1-168 (178) alignment
Range on Protein: 1307-1525
Range on HMM: 1-168/178.0
PYDHSRFKLQPVDDDEGSDYINANYVPGHnspreFIVTQGPLhstrDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVpvfygdikvqilndsh
|.|..|..|... . |.||||||... ..     ..... |      |.... .| . ..||.||  .| |..|||.||| ..                 
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

yadwvmtefmlcrgseqrilRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQintsdYVDIFGIVYAMRKE
                     ..... .||.|||. .. . .||.. .. .  ...|..||||||||||||.. .. ....      .... ..  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RVwMVQTEQQYICIHQCLL
|  .|... |.  .... |
Rp.ivpnpgqlrqLyefel

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1285-1533 7.7e-35 114.9 In-house 41-295 (310) alignment
Range on Protein: 1285-1533
Range on HMM: 41-295/310.0
DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQpVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY
|.  |.     .  |||.....  | || ||. .|     ||| ||||        ||..||||  |  ||||| ..  . .|..| .  |.|| ||  |
dssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPNDTVPVFYGDIKVQILNDSHYADWV---MTEFML--CRGSEQ----RIL--RHFHFTTWPDFGVPNPPQTLVRFvrafRDRIGAEQRPIVVHCSAGVG
||   |   || |.|  |..|     .      |.       ||    . |     ..  ||| |||.     |      |      . | |||||||..
wpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkd

RSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN
| .. ..|.  .....  ..||.  ..  ..|.|.  .||| ||. |..  ..   |...
rlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargete

PTPc_DSPc_SM00012 1426-1525 3.2e-34 112.7 In-house 2-104 (105) alignment
Range on Protein: 1426-1525
Range on HMM: 2-104/105.0
LRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQ--RPIVVHCSAGVGRSGTFITLDRILQQINTS-DYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
..|.|.|.|||.|||.... .....||...   ...   |.||||||||||.|||..|| .|||.... . |||| || ..||.| .|||||.||. ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLL
.||
all

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1326-1517 3.3e-32 106.5 In-house 77-270 (301) alignment
Range on Protein: 1326-1517
Range on HMM: 77-270/301.0
YINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP-VFYGDIKVQILNDSH-YADWVMTEFMLCRGS--
 | ||..| .  |. ||.|||||..|..||| |.   .   ||||..  ||  |||..| | ..   .  |  |..| |  .   . ..   .  . |  
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

--EQRILRHFHFTTWPDFGVPNPPQTLVRFVrafrDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQY
  . | . |. ...|.| |||.    |  ..    . .   ..|||||||||.||| .||. . . .....   ...   .  .|..|   |||..| 
kfatrtvthyqysewtdrgvPkshaelfdlm....elvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1263-1531 1.9e-30 100.6 In-house 14-279 (312) alignment
Range on Protein: 1263-1531
Range on HMM: 14-279/312.0
LMSADSdfRFSEEFEELKHVGRDQPCTfADLpCNRPKNRFTNILPYDHSRFKLQpvdDDEgSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWES
.||.    ... |.  .  .  |  || | |   .  ||. ||  .|  || |     ||   || ||.|     |  |..|||||..|   ||...   
mmstpq..qltkeykavgnivsdsect.afl.kfkdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalsl

NSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKV------QI----LNDSHYADWVMTEFMLCRGSEQRiLRHFHFTTWPDFGVPNPPQTLVRFVRA
 | .|..|.   | | ||| .|  .    |   | .|      .|        . .  |.   . . | | . | |. ...||| |.|.  .|  |.. |
gstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsa

FRDrigaEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
 .     ...|.. ||||||||.||.. .. ..  .      ..  .   .||.|   |..  ||.   .|.| .|  |
vkk....dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk

subfamily_CG42327_pd Subfamily CG42327 1274-1449 6.1e-30 99.0 In-house 9-186 (319) alignment
Range on Protein: 1274-1449
Range on HMM: 9-186/319.0
EEFEELKHVGRD-QpctfADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHN-SPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT
|||..|  .         .  .  ..|.|. |..|  ..|  || . ||. . |..|.|| |.. .|  .| .| .| ..  ||||. || .|| || ||
eefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

RCFEKGREKCDQYWPND-TVP--VFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFtTWPDFGVPNPPQTLVRF
  .|.| ..| .|.|   | .    ||||.| . .      .... ..| |  ..| | | |. .  |.. .||  ...|.  
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1287-1530 5.3e-28 92.8 In-house 26-272 (285) alignment
Range on Protein: 1287-1530
Range on HMM: 26-272/285.0
PCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDddegSDYINANY--VPGHNSpREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY
 ||..   .|   ||....   . .|  |.  |     ||| |..  .||..    .| |||||  |  |||.| .. .   ..||   || | |||  |
nctytayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPNDTVPV-FYGDIKVQI--LNDSHYADWVMTEFMLCR----GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRaFRDRIGAEQRPIVVHCSAGVGRSGT
.|.    |  .|  .. .   ..   |  ..  . .       ||   . | .   |||   |.  . .. . . .  ..  ...||.|||||||||. |
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk.wvkkvnpkekpicvhcsagvgrtat

FITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG
|. .|    .|     .... ||  ||  |.  ||.  |.. ..  |.  . |
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig

subfamily_egg_pd Subfamily egg 1288-1542 1.2e-27 91.4 In-house 32-281 (307) alignment
Range on Protein: 1288-1542
Range on HMM: 32-281/307.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKgrEKCDQYWP-
 | |    |. | |   .   | || ||.        |.| ||.| |.    |||..| ||  | |||||| .. . . |||||   |   |.|. ||| 
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

--NDTVPVFYGDIKVQILNDSHYADWV--MTEFMLCRG-SEQRILRHFHFtTWPDFGVPNPPQTLVRFVRafrDrigaEQRPIVVHCSAGVGRSGTFITL
  .|.. .  | .... |.  . || .  .|.. |  |  |.| | |.    .   .    |  ..| .|   .      .|.||..  || ...|....
aesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklr...n....lskpvvvqdilGvskaatlvai

DRILQQIN-TSDY-VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLegkENIVGPAREMH
.  | ..     .   .   |  .|..|   |..  .|. ... .| ..    ...| |.|. 
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff...rdvigsakeld

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1299-1401 5.1e-26 86.2 In-house 50-162 (350) alignment
Range on Protein: 1299-1401
Range on HMM: 50-162/350.0
KNRFTNILPYDHSRFKLQ----PVD----DDEGSDYINANYVPGH------NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY
|||..|||||.||| ||.    . |      ...|||||||.         |.   .| ||.|| || |||.... . . . |..||  .| ..|||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPNDTvpvfYGDIKVQI
|.. .    | ||.|..
Wqegs....ydditvkl

0048076 (Phosphotyrosine protein) phosphatases II 1420-1525 1.2e-23 78.8 In-house 41-140 (145) alignment
Range on Protein: 1420-1525
Range on HMM: 41-140/145.0
GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEqRPIVVHCSAGVGRSGTFITLDRILQqintsDYVDIFGIVYAMRKERVWMVQTEQQYIC
  . |   ..... |||.|||. ...| .|... .. . .. .|..|||||||||.||.. .. .|.       |... ..  .|. | ..|....|.. 
ellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

IHQCLL
.....|
lyefel

0048179 (Phosphotyrosine protein) phosphatases II 1424-1522 9.9e-23 75.9 In-house 47-139 (144) alignment
Range on Protein: 1424-1522
Range on HMM: 47-139/144.0
RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGaEQRPIVVHCSAGVGRSGTFITLDRILqqintSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
|   ..... |||.|||. .. | .|...... .  | .|..|||||||||.||........        .... ... .|. | ..|....|.. ...
regiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1409-1530 2.2e-22 74.0 In-house 76-196 (440) alignment
Range on Protein: 1409-1530
Range on HMM: 76-196/440.0
DWVMTEFMlcRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRD-RIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKER
|.. . ..   | | | |...|.  ||| |||.    ......   . .  | . |..||||||.||.|  |..| ||.. . || .||| .. .||..|
dyinasyi..ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnr

VWMVQTEQQYICIHQCLLAVLEG
  |||| .||  .|...|  |  
pqmvqtpeqyafvheavlegllc

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1335-1522 2.3e-20 67.6 In-house 1-198 (199) alignment
Range on Protein: 1335-1522
Range on HMM: 1-198/199.0
HNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfEKGRE-KCDQYWPNDT-VPVFYGDIKVQILNDSHYADWVMTEFMLCRG----SEQRILRH
|.. | .|.|| ||. |  |||.| ||. |  |||.    .| .|     |||        || . |     .  .|...| ..|.         | . |
hkgqrryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreish

FHFTTWPDFGVPNPpQTLVRFVRAFRDRIG---A-EQRPIVVHCSAGVGRSGTFITLDRILQQINTS--DYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
. ||.| .   ||    .| || | |.         . |..|||| | | .| |..||  ..  . |    ||.| .   .|. |. .. . |.|  |.|
yqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq





subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1339-1522 4.3e-20 66.7 In-house 4-197 (198) alignment
Range on Protein: 1339-1522
Range on HMM: 4-197/198.0
REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfEKGRE-KCDQYWPNDT-VPVFYGDIKVQILNDSHYADWVMTEFMLCRG----SEQRILRHFHFT
| .|.|| ||. |  |||.| ||. |  |||.    .| .|     |||        || . |     .  .|...| ..|.         | . |. ||
rryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDFGVPNPpQTLVRFVRAFRDRIG---A-EQRPIVVHCSAGVGRSGTFITLDRILQQINTS--DYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
.| .   ||    .| || | |.         . |..|||| | | .| |..||  ..  . |    ||.| .   .|. |. .. . |.|  |.|
swkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1296-1528 2.4e-18 60.6 In-house 51-285 (302) alignment
Range on Protein: 1296-1528
Range on HMM: 51-285/302.0
NRPKNRFTNILPYDHSRFKLQPVDDdegsDYINANYVPGHNSPREFIVTQGPLHSTR---DDFWRMCWESNSRAIVMLTRCFEKGReKCDQYWPND-TVP
|  ||. ...  .|. . ||.   |    .|.||  |   .  |. |..| |  ..    ..|||| .. .   .|.| .  |  .   ....|.     
nlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

VFYGDIKVQILNDSHYADWV---MTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF-RDRIGAEQrPIVVHCSAGVGRSGTFITLDRILQQ
. ||.. | .   ..  . .   . | .    |.  .    ..| |..  ||    .|.. .       | |.. ..|.    |.|| |.|.||   ...
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade.ntvivSknGaGRagafltlavavek

INTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..... . |  || ..|..|  .|.. .||. .. .||  .
lqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1421-1526 6.3e-18 59.6 In-house 212-342 (350) alignment
Range on Protein: 1421-1526
Range on HMM: 212-342/350.0
SEQRILRHFHFTTWPDFGVPNPPQTLVRFVR----------AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQ----------QINTSDYV-----D
|.  .. ....  |.| .. . |. ... .           |      |.. ||.||||||||| ||..||| .|.          . . .|.       
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IFGIVYAMRKERVWMVQTEQQYICIHQCLLA
|. ||  .|| |. |||. .|.| |...|| 
isiivnelrkqrismvqnldqfifiYeallf

fn3 Fibronectin type III domain 585-658 1.4e-17 56.7 Pfam-A 2-79 (85) alignment
Range on Protein: 585-658
Range on HMM: 2-79/85.0
PPRNMTIETVRSNSVLVHWSPPE--SGEFTEYSIRYRTDSEQQ-WVRLPSVRST-EADITDMTKGEKYTIQVNTVSFG
.|.|.... |.|.|. ..||||.  .|..| |...||...... |..    |.| .. .|... | .|...| .|. .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1350-1511 1.1e-16 55.7 In-house 38-204 (255) alignment
Range on Protein: 1350-1511
Range on HMM: 38-204/255.0
S-TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTV-PVFYGDIKVQILNdsHYADWVMTEFM-L-CRG--SEQRILRHFHFTTWPDFGVPNPP
| | | |...   ...  .|||.   |.|.|||..|.| .      . |..|   .    || |.     .   |   . . ..|.... |..   |. .
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

QTLVRFVRAFRDrigaeQRPIVVHCSAGVGRSGTFITLDRILQ----QINTSDYVDI--FGIVYAMRKERVWMV
. .   ... ||      ...|||||.|.||| .|.  . . |    ...|.. |..    ..  .|..|   .
reilnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkrai

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1323-1522 1.2e-16 55.8 In-house 45-253 (290) alignment
Range on Protein: 1323-1522
Range on HMM: 45-253/290.0
GSDYINANYVPGHNSpREFIVTQGPLHS-------TRDDFWRMCWESNSRAIVMLTRCFEKGRE----KCDQYWPNDTV-PVFYGDIKVQILNDSHYADW
 .||| ||.|   |   ..|.|| |..        |  .|| |  . ... .|||    || ..     | .| |.     . .....|.  .  .  | 
nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

VMTEFMLC-RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVrafrDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN-TSDYVDIFGIVYAMRKERV
 . | ..   . |.  . |  .  | .  |.. ..||.  .    . . |.. |..|||  |. || .. ...   | |  ||. | .  ...|.||.| 
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsli....qkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

WMVQTEQQYICIHQ
 ........  .  
laitsalelafvda

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1295-1522 3.1e-16 53.8 In-house 46-273 (303) alignment
Range on Protein: 1295-1522
Range on HMM: 46-273/303.0
CNRPKNRFTNILPYDHSRFKLQpvdDdegSDYINANYVPgHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFY
 |  ||||....  |||. ||    |   | || |.|.   .| .  |.|| ||  |  |||.|  | . . ...|    |  .   |  .|..   . .
knmdknrfvdvicldhskvkls...d...ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GD--IKVQILNDSHY-ADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNP-PQTLVRFVRAFRD--RIGAEQRPIVVHCSAGVGRSGTFITLDRI-LQQ
 .  |.|  ..       ||.    .  |. . .|   |. .||   .|.     .|. .   .   |  .. .| |    .|.||.|||  ..   |  
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

INTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQ
 .    .|.   .  .|. |.  ||   |.  .. 
hseqasldlvkclenvrngrlhavqnlsqfsvvyt

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1299-1407 6.3e-16 52.6 In-house 51-171 (349) alignment
Range on Protein: 1299-1407
Range on HMM: 51-171/349.0
KNRFTNILPYDHSRFKLQP----VDD----------DEGSDYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCD
|||. .||||.||| ||.                      |||||||.  .  .  . .| || || || |||...    . . .. |.  .|.. ||||
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPNDTvpvfYGDIKVQILNDSHY
.|| . .    | .|.|.. | | |
iywqels....ysnitvklqnssly

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1346-1531 1.2e-15 51.7 In-house 98-291 (302) alignment
Range on Protein: 1346-1531
Range on HMM: 98-291/302.0
GPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVF-YG-------DIKVQI--LNDSHYADWVMTEFMLCRG--SEQRILRHFHFTT
 | .||.. .| .  . |   .| |.   |.. .|| .|. ..   .. .|       ..| ..  . | . .     |.   .     .. .  ..|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDFGVPNPPQTLVRFVRaFRDrigAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
||| | |. ..| .  .. | .   . .. ..|||||||||.||....   .|   . .  |.  ||  .|. |   ||.||| | .  |.   |  |
wpdhGapkeaytaldilk.fce...sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek

subfamily_eak_pd Subfamily eak 1300-1441 1.4e-15 51.6 In-house 56-196 (332) alignment
Range on Protein: 1300-1441
Range on HMM: 56-196/332.0
NrFTNILPYDHSRFKLQPVDDDEgSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDT-VPVFYGDIK
|   .|.|||.   .| .   ..   ||||  .   .  |..|.|  . ..    ||.|  | .| |||.|    |.. || |.|.|..|   . .| ..
n.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPN
|.  .  . .   .  ..| .| |   . |...  | .. .| 
verkefvkrniletrllelskGnethrvlhykvfGwtettlpk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1464-1528 3.9e-15 50.0 In-house 1-65 (69) alignment
Range on Protein: 1464-1528
Range on HMM: 1-65/69.0
IVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
.|||||.| ||.||||..   . .| .   ||||  |  ||| |  ||  |..|| ||  |   |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

fn3 Fibronectin type III domain 866-936 7.2e-15 48.1 Pfam-A 2-79 (85) alignment
Range on Protein: 866-936
Range on HMM: 2-79/85.0
PITQLHATNITDTEISLRWDLP---KGEYNDFDIAYLTADNL--LAQNMTTRNE--ITISDLRPHRNYTFTVVVRSGT
....|.....|.|...|.|. |   .|..  ... | ....     .  ..|..   |...|.|...|.|.|  ..| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga

subfamily_hpo-7_pd Subfamily hpo-7 1348-1507 1.7e-14 48.3 In-house 43-206 (263) alignment
Range on Protein: 1348-1507
Range on HMM: 43-206/263.0
LHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTV-PVFYGDIKVQILNDSHyaDWVMTEFMLCR--G--SEQRILRHFHFTTWPDFGVPNP
|  | | |...   ...  .|||.   |.|.|||..|.| .      . ...|   .  .  | ..    |    |   . . ..|. .. |..   |. 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PQTLVRFVRAFRDrigaeQRPIVVHCSAGVGRSGTFITLDRILQ----QINTSDYVDI--FGIVYAMRKER
..  .. ... |.      ...|||||.|.|||  |   . . |    ...|.. |..    ..  .|..|
areilnilkvarn.....skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssr

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1465-1528 3.3e-14 47.0 In-house 1-64 (69) alignment
Range on Protein: 1465-1528
Range on HMM: 1-64/69.0
VVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
|||||.| ||.||||..   . .| .   ||||  |  ||| |  ||  | .|. ||. |   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_CG42327_pd Subfamily CG42327 1460-1524 7e-14 46.2 In-house 246-311 (319) alignment
Range on Protein: 1460-1524
Range on HMM: 246-311/319.0
EQRPIVVHCSAGVGRSGTFITLDRILQQINTS-DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCL
.| |.||||| ||||.|. |. |  ......|   |||  .|. .|..|   |.| .||  |.. |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1289-1445 1.9e-13 43.6 In-house 19-159 (169) alignment
Range on Protein: 1289-1445
Range on HMM: 19-159/169.0
TFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINAnyvpghnsprefivtqgplhstrddfwRMCWESNSRAIVMLTRCFEKGR---EKCD-QY
 .|.| ||  ||| .  |   | | ||| | .| |||||||                           || ||.|.  ||.|  . .|     || | | 
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyql

WPNDTVPVFYGDIKVQILNDSH---YADWVMTEFMLCRGSEQRILRH----FHFTTWPDFGVPNPPQT
 |   .  .| |      .  |    .   . | .|. .| .. . .    .|..|||. |||. |  
hpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh

fn3 Fibronectin type III domain 407-485 3.2e-13 42.8 Pfam-A 2-82 (85) alignment
Range on Protein: 407-485
Range on HMM: 2-82/85.0
PVRNLRSINDdKTNTMIITWEADP--ASTQDEYRIVYHELETFN-GDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMES
...||. ..   .... ..|.. .   .. . |.. | | .. .   . |.. . |..||. | ||..|...||||... |.
aPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngageg

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1289-1445 1.1e-12 41.2 In-house 20-160 (169) alignment
Range on Protein: 1289-1445
Range on HMM: 20-160/169.0
TFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINAnyvpghnsprefivtqgplhstrddfwRMCWESNSRAIVMLTRCFEKGR---EKCD-QY
 .|.| ||  ||| .  |   | | ||| | .| |||||||                           || ||.|.  ||.|  . .|     || | | 
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyql

WPNDTVPVFYGDIKVQILNDS----HYADWVMTEFMLCRGSEQRIL---RHFHFTTWPDFGVPNPPQT
 |   .  .| |      .      .  . ..   |.    .. .    . .|..|||. |||. |  
hpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1250-1346 2.1e-12 41.1 In-house 3-95 (95) alignment
Range on Protein: 1250-1346
Range on HMM: 3-95/95.0
RPILIKNFAEHYRLMSADSDFRFSEEFEELKHvGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDdegSDYINANYVPGHNSPREFIVTQG
.|| .  |  |   | ..||  | .||  .       | |     .| ||||| ||.||| .|  |    |   |||||| .| |.     .| .||
kpihvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg

fn3 Fibronectin type III domain 961-1043 5e-12 39.0 Pfam-A 3-84 (85) alignment
Range on Protein: 961-1043
Range on HMM: 3-84/85.0
VERFHPTDVQPSEINFEWSLPSsEANGVIRQFSIAYTNINNLT-DAGMQDFESEEaFGVIKNLKPGETYVFKIQAKTAIGFGPE
.|... ..|........|| |. . .| |  ... | . ..   .   .  ....   ....|||| .|.|..|| .. | |||
PenlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 220-299 5.9e-12 38.8 Pfam-A 3-80 (85) alignment
Range on Protein: 220-299
Range on HMM: 3-80/85.0
PGKFIVWFRNETTLLVLWQPP-YPAGIYTHYKVSIEPPDANDsvlyVEKEGEPPGPA-QAAFKGLVPGRAYNISVQTMSEDE
|. . |  ...|.| . |.||  . | .|.|.|  .. . ..    ..||   |... .. ..|| ||. |...||. ... 
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngag

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1249-1337 6.1e-12 39.6 In-house 3-88 (440) alignment
Range on Protein: 1249-1337
Range on HMM: 3-88/440.0
NRPILIKNFAEHYRlmSADSDFRFSEEFEeLKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNS
.|||.. .||.. .  .      | .|.  |   |  ||.  | || |. |||. ||| |||||  |. |     |||||| |. | .|
qrpiivadfadyvq..nnrrsrafedews.llpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1459-1528 6.8e-12 39.4 In-house 263-344 (349) alignment
Range on Protein: 1459-1528
Range on HMM: 263-344/349.0
AEQRPIVVHCSAGVGRSGTFITLDRILQ--QINTSDYVD----------IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL
..  ...|||||| ||.|...||| .|.  .  . ...           |. ||  .|| |. |||  .|.| |...||  .
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

fn3 Fibronectin type III domain 124-202 4e-11 36.1 Pfam-A 1-79 (85) alignment
Range on Protein: 124-202
Range on HMM: 1-79/85.0
DPPSNLSVQVRSGKNAIILWSPPT--QGSYTAFKIKVLGLSEASssYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDG
..|.||||  ..  .. . ||||.  .| .| .....   .. .  . ..|.|  .| .. ...|.||..|... ... ..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 315-391 1.2e-10 34.5 Pfam-A 3-79 (85) alignment
Range on Protein: 315-391
Range on HMM: 3-79/85.0
PLNVTFDRDfiTSNSFRVLWEAPK-GISEFDKYQVSVATTRRQS-TVPRSNEPVA-FFDFRDIaEPGKTFNVIVKTVSGK
| |....    ||.|... |..|| | .....|.| ..... .. .. ..... .  . .... .||..... |..|.|.
Penlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgL.kpgteYefrVqavnga

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1462-1527 2.7e-10 34.6 In-house 229-294 (297) alignment
Range on Protein: 1462-1527
Range on HMM: 229-294/297.0
RPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAV
 ...|||||||||||  .  | ||...      |.  |.  .|..|  .||| .|.  ...  |. 
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1306-1416 1.6e-09 32.2 In-house 3-100 (130) alignment
Range on Protein: 1306-1416
Range on HMM: 3-100/130.0
LPYDHSRFKlqpvdddeGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfekgrEKCDQYWPnDTVPVF-Y-GDIKVQiLN
|... || .        | .||||..|   .  .|.. || ||  |  |||.|  |     .|.|        |. |.||| |. |.  |  || |  | 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.....eeedeywp.dsePlewyeediivt.lt

DSHYADWVMTEFM
| .  . . ....
drdefknikasnl

fn3 Fibronectin type III domain 683-753 6.9e-09 28.9 Pfam-A 11-77 (85) alignment
Range on Protein: 683-753
Range on HMM: 11-77/85.0
VDSRNITLEWPKP---EGRVESYILKWWPSDNPGRVQTKNVSENksaddlsTVRVLIGELMPGVQYKFDIQTTS
| |...||.| .|   .| ...| ..........  ....|...       | .| . .| || .|.| .|. .
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.......ttsvtltgLkpgteYefrVqavn

PTEN_1 1433-1480 8.5e-09 30.5 In-house 101-149 (196) alignment
Range on Protein: 1433-1480
Range on HMM: 101-149/196.0
TWPDFGVPNpPQTLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFIT
 ..|.|.|.  . | .... | . . .  ... ..||| ||.||||| . 
pieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1272-1335 9.2e-09 29.3 In-house 15-77 (244) alignment
Range on Protein: 1272-1335
Range on HMM: 15-77/244.0
FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPvDDDEGSDYINANYVPGH
  |||  |    |.   | | | .|  |||. ||||.|..|  |      ||||||||||. | 
akeefvglsdhtreflqtnavlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs

fn3 Fibronectin type III domain 511-570 1e-08 28.4 Pfam-A 16-80 (85) alignment
Range on Protein: 511-570
Range on HMM: 16-80/85.0
LNISWKSD--VNSKQEQYEVLYSRNGTSD-LRTQKTKESR--LVIKNLQPGAGYELKVFAVSHDL
|..||.     ... . ||| |.  |...  ........   .....|.||. ||..| ||. . 
ltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1288-1368 1e-08 29.1 In-house 29-114 (347) alignment
Range on Protein: 1288-1368
Range on HMM: 29-114/347.0
CTFADLPCNRPKNRFTNILPYDHSRFKLQPVDD-----DEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIV
.|...   .  |||  .    | .|  | | .      |.   |||| ..   |. .|.|.|| || .|  |||.|    .   .|
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1286-1381 3.5e-08 27.3 In-house 24-118 (332) alignment
Range on Protein: 1286-1381
Range on HMM: 24-118/332.0
QPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDegSDYINANYVPGHNSPREFIVTQGPLHS-TRDDFWRMCWESNSRAIVMLTRCFEKGREKC
 | |.  .  |   ||   .  .|||| .| | |     |. ||..| |..    .|..| |.   |   ||||  | .   |...    || . |.
ypntydkflnnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

Tissue_fac Tissue factor 584-657 7.8e-08 21.1 Pfam-A 23-101 (107) alignment
Range on Protein: 584-657
Range on HMM: 23-101/107.0
NPPRNMTIETVRSNSVLvHWSP-PESGEFTEYSIRYRTDSEQQWVRL---PSVRSTEADITDMTK--GEKYTIQVNTVSF
 .|.|......  ...| .|.| ..| | . |.. |.. |..|| ..    ....|| |.|. |.   |||...| ..| 
pkPqnvqfqsrnfkniL.sWepgsaspesvvYtVqykmkssrqwknvedCtniteteCDLtsetsdiqekyyarVraesg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1339-1399 1.2e-07 25.4 In-house 236-293 (440) alignment
Range on Protein: 1339-1399
Range on HMM: 236-293/440.0
REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKgreKCDQYWPNDTVPVFYGDIKV
  || || || ||  ||||.  . .  .|.|| .  .|    |  ||| .|  | .| . |
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftv

0038934 (Phosphotyrosine protein) phosphatases II 1430-1480 1.8e-07 26.5 In-house 83-134 (194) alignment
Range on Protein: 1430-1480
Range on HMM: 83-134/194.0
HFTTWPDFGVPNPPQTLVRFVRAFRDRIGAE-QRPIVVHCSAGVGRSGTFIT
.   .||.|.. . ..| ||...  . . .  .  ..||| ||.||.||.. 
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

subfamily_PTPDC1_pd Subfamily PTPDC1 1429-1524 2.6e-07 25.3 In-house 85-172 (182) alignment
Range on Protein: 1429-1524
Range on HMM: 85-172/182.0
FHFTTWPDFGVPnPPQTLVRFVRAFRDRIGAEqrPIVVHCSAGVGRSGTFITLDRILQQINTSDYvdifgIVYAMRKERVWMVQTEQQYICIHQCL
..  .|.|.||. . ....  |.     .  .   . ||| || || |  |.   . ..  |..       .  .|..|   .|| .|  ....  
vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaek.....aiklvrskrpksiqtreqvelvkefa

0048567 (Phosphotyrosine protein) phosphatases II 1429-1530 5.1e-07 24.2 In-house 40-148 (157) alignment
Range on Protein: 1429-1530
Range on HMM: 40-148/157.0
FHFTTWPDFGvPNPPQTLVRFVRAFRDRI---GAEQRPIVVHCSAGV---GRSGTFITLDRILQQinTSDYVDIFGIVYAMRKERVWMVQTEQ----QYI
.... . ||| | .  .|.||.. . . .     . ..|.|||.||    ||..|.| .  || .    .  ......  .|   |.  .  .    ...
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl..gftpeeaiaplrivrpgsvpfrdasyllslynl

CIHQCLLAVLEG
... .| ..| .
tlldvlyGllkA

fn3 Fibronectin type III domain 785-850 5.3e-07 22.9 Pfam-A 12-79 (85) alignment
Range on Protein: 785-850
Range on HMM: 12-79/85.0
ERDTITLSYTPTPQSSSKFDIYRF---SLGDAEiRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGG
  ...||| .| .. ..... |.    . |. |  .||. .  | . ||.||| ||. |...| .|.|.
tstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavnga

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1340-1403 5.8e-06 20.1 In-house 138-197 (244) alignment
Range on Protein: 1340-1403
Range on HMM: 138-197/244.0
EFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCfekgrEKCDQYWPNDTVPVFY-GDIKVQILN
|.|.|| ||  |  |||.|  |     .|.|        |. |.|||.     .|  || | . .
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.....eeedeywpdseplewyeeditvtltd