Gene DUSP2 in Homo sapiens

Synonym: PAC-1, PAC1, DUSP2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP010_AA protein Get Run
HsapP010_AA_170-312 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 163-313 2e-68 223.6 In-house 10-158 (163) alignment 
Range on Protein: 163-313
Range on HMM: 10-158/163.0
SRAPVYDqggPVE-ILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGI
.....||   ||| ||..|.|||....|.|. |...||||.||||....|.|| ||.||....||... .||..|.|.| ||| ||...|.||.||||||
dklklyd...PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGi

SRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLC
|||.|.||||||...||.|.|||||||||| .||||..|..|||..|...|.
sRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
subfamily_DSP10_pd Subfamily DSP10 173-310 3.5e-53 173.7 In-house 14-152 (159) alignment 
Range on Protein: 173-310
Range on HMM: 14-152/159.0
PVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEG-LFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAY
 ...||.|||||   ..||. |.  .||||||| .|.||.||.  ..|| |||.|..  ...  |.||. ||. ....| |||||||||||||||. .||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
||. ... | .|..|||..| .||||..||||||.|| .
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
subfamily_DSP6_pd Subfamily DSP6 171-311 1.4e-52 171.4 In-house 12-154 (158) alignment 
Range on Protein: 171-311
Range on HMM: 12-154/158.0
GGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFE--GLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATIC
  ||||||.|.|||  ..|.|. |.  .|  ||||    || ||  | ..|. ||.||. . .....| ||| |||  ...   ||||| |||||| |..
efpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvt

LAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
|||||... . |..|.|.||.|.  |||||.||||||.|| ..
laylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
DSPc Dual specificity phosphatase, catalytic domain 180-310 5.5e-46 150.7 Pfam-A 1-133 (133) alignment 
Range on Protein: 180-310
Range on HMM: 1-133/133.0
LFLGSCSHSSdLQGLQACGITAVLNVSASCPN-HF--EGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSR
|.|||.|..| |. |...|||.|.||. ..|| ..  .. ..| .|||||..  .||....||. ||. ....|..||||||||||||||...||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
...|.||..|||.||. ||||..|..|||..|..
nlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 180-310 5.5e-46 150.7 In-house 1-133 (133) alignment 
Range on Protein: 180-310
Range on HMM: 1-133/133.0
LFLGSCSHSSdLQGLQACGITAVLNVSASCPN-HF--EGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSR
|.|||.|..| |. |...|||.|.||. ..|| ..  .. ..| .|||||..  .||....||. ||. ....|..||||||||||||||...||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
...|.||..|||.||. ||||..|..|||..|..
nlslneAyefvkerrskispnagflrqLleyerk
PTPc_motif_SM00404 173-309 5.5e-45 147.7 In-house 2-139 (140) alignment 
Range on Protein: 173-309
Range on HMM: 2-139/140.0
PVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPN-HFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAY
| .|||.|.|||.|...... |.. |||.|.||. ....   .  |....||..||.  ..|....... ||. ....||.||||||||.|||||...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFET
||..| . |.||..|||.||  ||||..|. ||...|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0044763 (Phosphotyrosine protein) phosphatases II 165-310 6.8e-45 148.2 In-house 15-169 (178) alignment 
Range on Protein: 165-310
Range on HMM: 15-169/178.0
APVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGL---------FRYKSIPVEDNQMVEISAWFQEAIGFIDWVK-NSGGRVL
 . .|. ...||||.|.|||. ...||. |.. |||...|..  ....|...         ..|. ||..|.   .....|.|.. ||. .  ..||.||
lersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvl

VHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGvISPNFSFMGQLLQFETQ
|||.||..||.|...|||| .... |.||...|..||  |.||.... ||..|| .
VHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_DSP8_pd Subfamily DSP8 167-313 7.3e-45 146.4 In-house 10-156 (159) alignment 
Range on Protein: 167-313
Range on HMM: 10-156/159.0
VYDqGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHF-EGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSA
| |  || .||..|.|||  .. . . |.. ||. |||.| |||.       ..  .||.|..  ... ||.... ||| .|.. ||||||. |||||||
vad.vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsa

TICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLC
|. .||.|.  .. ||||. |||..| .||||. |.||||..| .. .
tvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_DSP19_pd Subfamily DSP19 175-311 1.4e-42 139.6 In-house 14-150 (152) alignment 
Range on Protein: 175-311
Range on HMM: 14-150/152.0
EILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQ
|. |.|.|||..  .| . |.  .|| .|||..  ||.|   | |.||.. |..  .......||..||. .... |.|||||.||.||||.. .||||.
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

SRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
.....| ||.. |.. |  |.||  |. || ..|...
keelsleealelvrearpcikPneGFikqLkeyeael
0048076 (Phosphotyrosine protein) phosphatases II 171-311 4.1e-39 128.9 In-house 2-142 (145) alignment 
Range on Protein: 171-311
Range on HMM: 2-142/145.0
GGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLA
..| ||||.|.|||. . .||. |.  |||.|||..  ......  ..|  .|..|..  .......|.. ||. . ..||.|||||.||..|..|...|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
||| ...| |.||...|...|  . ||.... .|..||...
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP14_pd Subfamily DSP14 174-311 4.1e-39 128.0 In-house 8-144 (157) alignment 
Range on Protein: 174-311
Range on HMM: 8-144/157.0
VEILPYLFLGsCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLM
..| |.|||. .. ... . |.. .||...||.   ||.    ...  .|||||. ......|.|..  |. ||..||..|||| ||.||||..||||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

QSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
. ... | ||.  ||..| .|.||  |  || ..|...
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0048179 (Phosphotyrosine protein) phosphatases II 172-309 4.1e-38 125.7 In-house 3-142 (144) alignment 
Range on Protein: 172-309
Range on HMM: 3-142/144.0
GPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLF--RYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICL
 |.||||.|.|||. ...||. |.. |||.|.|.. .....|.. .  .|  .|..|..  .......|.. ||. . ..||.|||||.||..|..|...
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFET
||||  ... |.||...|..||  . ||.... .||..|.
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_Slingshot_pd Subfamily Slingshot 173-309 4.7e-38 124.2 In-house 19-155 (169) alignment 
Range on Protein: 173-309
Range on HMM: 19-155/169.0
PVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYL
. .|  ...|||   .|.|. |.  |.. .|||.  . |.|.. |.|. | | |..  .. ....|.  ||. .|..| .|||||. |.||||.. .|| 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFET
|.. .. |.||...||.|| || || .|. || ..| 
mkeyglsleealeyvkerrsvikPnkgflkqleeyeG
PTEN_1 169-312 8.4e-37 121.9 In-house 37-192 (196) alignment 
Range on Protein: 169-312
Range on HMM: 37-192/196.0
DQGGPVEILPYLFLGSCSHS-SDLQGLQACGITAVLNVSASCPN---------HFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVK--NSGGRVLVH
..... || . |..|| ..  .||. |.. |||.|.|.|  ...         .|.. ..|...|.|| .   .| .| ..  ||.|..  ..|. ||||
srpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVH

CQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVL
|.||..||.|.. ||||....   |||...|...| ...|| ... .||... . |
CkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0043147 (Phosphotyrosine protein) phosphatases II 171-311 2.7e-36 120.3 In-house 17-160 (172) alignment 
Range on Protein: 171-311
Range on HMM: 17-160/172.0
GGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSAS---CPNHFEGLFRYKSIPVEDNQMVeISAWFQEAIGFIDW--VKNSGGRVLVHCQAGISRSA
  | ........... ...... |.  |||...|.      ... ..  ..|  .|..|.    ......|.. |||   ....||.||||| ||..|..
yipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtg

TICLAYLMQsRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
|...||||. ... |.||...|...|. ...|.|.. .|..|| ..
tlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0041856 (Phosphotyrosine protein) phosphatases II 164-310 1.3e-35 118.0 In-house 10-171 (182) alignment 
Range on Protein: 164-310
Range on HMM: 10-171/182.0
RAPVYDQGGPVEILPYLFLGSCSH--------------SSDLQGLQACGITAVLNVSasCPNHFEGLF-----RYKSIPVEDNQMVEisawFQEAIGFID
  |..   .. .|...|.|||. .               ..|. |.  |||...|..  .....  |.     .|. .|..|.   .    ..|.. ||.
ilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfie

WVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRG--VISPNFSFMGQLLQFETQ
.|...||.||||| ||..|..|...|||| ...| |.||...|..||   ||.||. |. ||. .| .
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_LRR-DSP_pd Subfamily LRR-DSP 173-313 3.9e-35 115.2 In-house 120-260 (263) alignment 
Range on Protein: 173-313
Range on HMM: 120-260/263.0
PVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSI-PVEDNQMVEISAWFQEAIGFIDWVKNSGGrVLVHCQAGISRSATICLAY
| ||.. ||||.   . .   |.  |.| .|   | .   |  ||.| ||  .|| .  .|| .|.|   ||.  ...|| |||||.||.|||.|. ..|
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisy

LMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLC
||. .|... ||.|.|...|  | ||  |. ||...| .. |
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 173-309 5.1e-35 114.2 In-house 7-145 (148) alignment 
Range on Protein: 173-309
Range on HMM: 7-145/148.0
PVEILP-YLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGL-FRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLA
| || . .|||||  . .||. |.| |.|.. | .....| ..    .|  ....|..  ..|| |...| |.. .|. |.|||||.| |.|||. . |.
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFET
.|.. .|| | ||...||..|  . ||  |. || ..| 
wlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0049260 (Phosphotyrosine protein) phosphatases II 173-309 7.1e-34 112.1 In-house 8-147 (152) alignment 
Range on Protein: 173-309
Range on HMM: 8-147/152.0
PVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNH---FEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDW-VKNSGGRVLVHCQAGISRSATIC
| |.......|. ....... |.  |||.....   ....   .| ...|. .|..|.   ..| ...... ||..  ...||.||||| ||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

LAYLMQsRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFET
.||||  ..| |.||...|...| .. ||.... .|..||.
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_DSP15_pd Subfamily DSP15 175-310 2.5e-33 109.3 In-house 4-138 (151) alignment 
Range on Protein: 175-310
Range on HMM: 4-138/151.0
EILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGlFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQ
..|| |.||    |.| . |.   || .|.|. .  ....  ..|| |...|   ...| .|.|.. ||   .  .. ||||| ||.|||.|.. |||| 
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

SRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
   .   .|....|..| |  ||| |  || ..|..
vtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP12_pd Subfamily DSP12 175-309 3.9e-33 109.0 In-house 4-141 (155) alignment 
Range on Protein: 175-309
Range on HMM: 4-141/155.0
EILPYLFLGSCSHSSDLQGLQACGITAVLNVSASC-PNH--FEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAY
.||| |.||. ..  . . |. ..||.|| |     |.|   .|  ..|.|.. |.. ..|  ...||. ||.   . .| ||||||||.|||.||..||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFET
||.. .. |..|...||. .  |.|| .|. ||  || 
lmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_MKPLT_pd Subfamily MKPLT 179-312 5.2e-33 107.9 In-house 28-161 (164) alignment 
Range on Protein: 179-312
Range on HMM: 28-161/164.0
YLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRV
 |.||  .|. . . |..  || ..|||  . . |   . |  . |||.   ..|.... |  |.    .|||||||||. | |||... .|.|..|.. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

RLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVL
 |.||....|.|| ...||  |. || .||  .|
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 179-312 5.2e-33 107.9 In-house 28-161 (164) alignment 
Range on Protein: 179-312
Range on HMM: 28-161/164.0
YLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRV
 |.||  .|. . . |..  || ..|||  . . |   . |  . |||.   ..|.... |  |.    .|||||||||. | |||... .|.|..|.. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

RLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVL
 |.||....|.|| ...||  |. || .||  .|
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_DSP3_pd Subfamily DSP3 175-310 6.5e-33 107.7 In-house 13-156 (162) alignment 
Range on Protein: 175-310
Range on HMM: 13-156/162.0
EILPYLFLGSCSHSSDLQGLQACGITAVLNVSASC-------PNHFEG-LFRYKSIPVEDNQMVEISAWFQEAIGFIDW-VKNSGGRVLVHCQAGISRSA
|. | |..|  . ..| . |.. ||| ||| ...        ......  ..|  ..|.|......|..|..|  |||  .... |.|||||..|.||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TICLAYLMQSRRVRLDEAFDFVKQRRGvISPNFSFMGQLLQFETQ
|. ||||| .|.. | ||   |...|  | ||  |. || .....
tlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldee
0046846 (Phosphotyrosine protein) phosphatases II 168-310 1.2e-32 108.4 In-house 7-171 (176) alignment 
Range on Protein: 168-310
Range on HMM: 7-171/176.0
YDQGGPVEILPYLFLGSCS----------HSSDLQGLQACGITAVLNVSASC-------PN----HFEGLFRYKSIPVEDNQMVEIsAWFQEAIGFIDWV
........|...|.|||.           . ..|. |.  |||||.|.           ||      .  ..|. .|..|..  .. ....|.. ||. .
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirea

KNSGGRVLVHCQAGISRSATICLAYLMQS-RRVRLDEAFDFVKQRRG-VISPNFSFMGQLLQFETQ
 ..||.|||||.|||.|..|...|||... . . ..||...|...|   . ...... .| .|| .
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0049772 (Phosphotyrosine protein) phosphatases II 184-310 7.5e-32 106.7 In-house 156-272 (314) alignment 
Range on Protein: 184-310
Range on HMM: 156-272/314.0
SCSHSSDLQGLQacgitavlnvsaSC---PNHFEGL-FRYKSIPVEDnQMVEISAWFQEAIGFIDWVkNSGGRVLVHCQAGISRSAT-ICLAYLMQSRRV
.  . .||. |.            ..   |..||.| ..|. |||.|   . ....|.|.. ||. . . ||.|||||.||..|..| ...||||  ..|
neptaadlellk............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgv

RLDEAFDFVKQRRGvISPNFSFMGQLLQFETQ
 |.||...|...|  |.||..|. ||.|.| .
sleealedvrlkRp.inpnpgfieqleqyefi
0045098 (Phosphotyrosine protein) phosphatases II 169-311 8e-32 106.1 In-house 18-271 (278) alignment 
Range on Protein: 169-311
Range on HMM: 18-271/278.0
DQGGPVEILPYLFLGSCS-----------------------------------------HSSDLQGLQACGITAVLNVS---------------------
 .| | ||.|.|.||. .                                         ...... |.  |||.....                      
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------ASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKN--------------SGGRVLVHCQAGI
                               .......   . |...|  .    .|...|.|.. ||. . .              |||.|||||.||.
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSATICLAYLMQSR---RVRLDEAFDFVKQRRGV-ISPNFSFMGQLLQFETQV
.|..|...|||| ..   .| |.||.......|.  . .|.... .| .|. ..
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0036282 (Phosphotyrosine protein) phosphatases II 172-309 4.4e-30 100.1 In-house 11-167 (174) alignment 
Range on Protein: 172-309
Range on HMM: 11-167/174.0
GPVEILPYLFLGSCSHSsDLQGLQACGITAVLNVSASCPNH---------------FEGLFRYKSIPVEDNQMVEISAwFQEAIGFIDWVKNS--GGRVL
. ..|.|.|..|.. .. ... |.  |||.|...  .....                .  ..|. .|..|... ..|  ..|.. |.. . ..  || ||
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCQAGISRSATICLAYLMQSRRV-RLDEAFDFVKQRR---GVISPNFSFMGQLLQFET
||| ||..|..|...||||  .   .|..|.|.|...|   . . ...|.. .| .|| 
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0037934 (Phosphotyrosine protein) phosphatases II 170-310 1.6e-28 95.3 In-house 36-240 (243) alignment 
Range on Protein: 170-310
Range on HMM: 36-240/243.0
QGGPVEILPYLFLGSC--------SHSSDLQGLQACGITAVLNVSASC---------------------------------------------PNHFEGL
 .. ....|.|.....         . |... |.  |||.....   .                                             ....   
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

FRYKSIPVED----NQMVEISAWFQEAIGFIDW-----VKNSGGRVLVHCQAGISRSATICLAYLMQSR-RVRLDEAFDFVKQRRGV-ISPNFSFMGQLL
..|  .|. |    . .  . ....|.. ||.      . .|||.||||| ||..|..|...|||| .. .| |.||.......|.  . ...|.. .| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

QFETQ
... .
ealle
subfamily_STYX_pd Subfamily STYX 175-311 2.1e-28 92.5 In-house 14-157 (166) alignment 
Range on Protein: 175-311
Range on HMM: 14-157/166.0
EILPYLFLGSC--SHSSDLQGLQACGITAVLNVSASC-----PNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATI
|||| ||||    .  | |. |.  ||| .. .  .         |.  |||  . | || . .|  .. .  .|||   ..||.|||| .|||||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

CLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
 .||.|..  ..  ||| .|..||  |.||  |. || ..|.  
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
0040439 (Phosphotyrosine protein) phosphatases II 175-310 8.6e-28 93.0 In-house 31-244 (249) alignment 
Range on Protein: 175-310
Range on HMM: 31-244/249.0
EILPYLFLGSCSHSSDLQG------------------------LQACGITAVLNVSASCPN---------------------------------------
.||| |||..  . | . |                        |.  |||......  ...                                       
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

----HFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKN------SGGRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISP
     .   .... |.. |     .. .|.... ||..|..      .||.||||| ||..|..|...||||       ..| |.||.......|. . .
ltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NFSFMGQLLQFETQ
|.... .|.... .
npeqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 175-306 7.2e-26 86.0 In-house 10-148 (151) alignment 
Range on Protein: 175-306
Range on HMM: 10-148/151.0
EILPYLFLGSCSHSSDLQGLQACGITAVLNVSA-----SCPNHFEG-LFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNS-GGRVLVHCQAGISRSATI
 . ..|..... .. .|. |.  ||....|.        ||. ..   .... ||..|..   .. .|.... |.... .  .| ||||| ||..|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

CLAYLMQsRRVRLDEAFDFVKQRRG-VISPNFSFMGQLLQ
...|||  ..| |.||.......|. |. ||  |. ||..
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
0045450 (Phosphotyrosine protein) phosphatases II 192-310 1.7e-25 85.9 In-house 125-302 (307) alignment 
Range on Protein: 192-310
Range on HMM: 125-302/307.0
QGLQACGITAVLNVSASCPN-----------------------------HfEGLFRYKSIPVEDN-----------------QMVEISAWFQEAIGFIDW
. |.  |.|...... ....                             | .. . .  ..|.|.                     .. .|.|.. ||. 
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VKN------SGGRVLVHCQAGISRSATICLAYLMQSRR--------VRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
|..      .||.||||| ||..|..|...|||| ...        | |.||.......|. . .|.... .| ... .
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 175-310 4.5e-25 83.9 In-house 49-241 (245) alignment 
Range on Protein: 175-310
Range on HMM: 49-241/245.0
EILPYLFLGSCSHSSDLQ----GLQACGITAVLNVSASCPNHFEGLFRY----------------------------------------------KSIPV
.| | ...... ......     |.  |||......   ...... ..|                                                .|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

EDNQMVEISAWFQEAIGFIDWVKN--SGGRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
.|... .......... |.. . .  |.|.||||| ||..|..|...||||       ..| |.||.......|. . ...|.. .| ... .
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 173-312 9.1e-25 80.7 In-house 11-154 (157) alignment 
Range on Protein: 173-312
Range on HMM: 11-154/157.0
PVEILP-YLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFR---YKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATIC
|||.||  |.||  ... . .  .   . |..|||  . . ..|.        |.|||..  ..   ..||. ||.  |..|  |||  . ||||||.. 
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

LAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVL
.|||| |... | .|....|. .  . || .|. || ..| |.|
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 179-311 1.4e-23 76.9 In-house 9-152 (154) alignment 
Range on Protein: 179-311
Range on HMM: 9-152/154.0
YLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGL---------FRYKSIPVEDNQMVEISAWFQEAIGFIDWVK--NSGGRVLVHCQAGISRSATI
.|...|   . .   ||   |. .|||.   .| |            . |  . . |.   .|   .. |  |||        ..||||...|.||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

CLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
 ..|||..... | .|. ..|. | .|.||  |. || .|| . 
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
0039614 (Phosphotyrosine protein) phosphatases II 197-310 2.3e-22 75.2 In-house 124-287 (297) alignment 
Range on Protein: 197-310
Range on HMM: 124-287/297.0
CGITAVLNVSASCPN--------------------------------------------HFEGLFRYKSIPveDNQMVEISAWFQEAIGFIDWVKN---S
 |.|.....   ...                                            ..   | | ..|  |..  .... ..|.. ... . .   .
qgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrealaelpk

GGRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
||.||||| ||..|..|...||||       ..| ..||.......|. . ...|.. .| ... .
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0040438 (Phosphotyrosine protein) phosphatases II 198-309 3.5e-22 74.5 In-house 110-273 (317) alignment 
Range on Protein: 198-309
Range on HMM: 110-273/317.0
GITAVLNVSASCPNH---------------------------FEGLFRYKSIPVEDN----------------QMVEISAWFQEAIGFIDWVKNS----G
|.| ....  ....                             .. . .  ..|||.                    .  .... . |...|...    |
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpg

GRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFET
| ||||| ||..|..|...||||     . ..| ..||.......|. . ...... .| ... 
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall
0036941 (Phosphotyrosine protein) phosphatases II 175-311 4.2e-22 74.2 In-house 21-276 (297) alignment 
Range on Protein: 175-311
Range on HMM: 21-276/297.0
EILPYLFLGSCSHSSDLQGLQ----------------------------------------------------------ACGITAVLNVSASCPNHFEGL
|.||.|.|||.|... .. |.                                                            ..| .....   .. .|  
ellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

FRYKSIP-----------------------------------------------VEDNQMVEISAWFQEAIGFIDWVKN------SGGRVLVHCQAGISR
..| .                                                 . .     .  .... . ||..|..      |||.||||| ||..|
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

SATICLAYLM--------QSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
|.|...|.||          ..| . ||. .....|  . ...... .| ... . 
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0051429 (Phosphotyrosine protein) phosphatases II 178-312 1.4e-21 72.8 In-house 21-225 (272) alignment 
Range on Protein: 178-312
Range on HMM: 21-225/272.0
PY-LFLGSCS---HSSDLQGLQACGITAVLNVSASCPNHFEGL------FRYKSIPVEDNQMVEISAWF-------------------------------
|  |.....       |.. |.  ||......   .   ...       .||  .|..|.   .|. ..                               
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------QEAIGFIDWVKNsGGRVLVHCQAGISRSATICLAYLMQsRRVR--------------LDEAFDFVKQRRGVISPNFSFMGQLL
                 .. . ..... . ||.||||| ||..|..|.....|.  ..|               |.|| . ....|  . ..  .. .|.
evmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

QFETQVL
... ..|
eallell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 180-311 1.5e-21 70.1 In-house 6-141 (145) alignment 
Range on Protein: 180-311
Range on HMM: 6-141/145.0
LFLGSCSHSSDLQGLQACGITAVLNVSASC----PNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQS
|. ||  |..|.  ||  ||. ..|..|.      .     .    |  || .  ..|  |.|   |||  |. |  |.||| ||.||| |. .|.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

RRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV
  . | ||   |. .|    ||  |. .||..| |.
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0038934 (Phosphotyrosine protein) phosphatases II 191-310 8.9e-21 69.8 In-house 49-175 (194) alignment 
Range on Protein: 191-310
Range on HMM: 49-175/194.0
LQGLQACGITAVLNVSASCP----NHFEGL-FRYKSIPVEDNQMVEISAWFQEAIGFIDWV--KNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEA
.  |. .....|.... . .    ..||.. ..| ..|..|   |   .  .. . ..| .  ...|| |.||| ||..|..|.. |||.....  ..||
ylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeA

FDFVKQRRGVISPNFSFMGQLLQFETQ
 ......|. . || ... .||..  .
ialfrekRpgaipnqdyleallkryke
0043336 (Phosphotyrosine protein) phosphatases II 207-308 1.3e-19 66.2 In-house 168-273 (278) alignment 
Range on Protein: 207-308
Range on HMM: 168-273/278.0
ASCPNHFEGLFRYKSIPvEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISPNFSFM
 . . ..   . |...| ...    .|  ..    .......|.| ||||| ||..|..|....||.       ..| |.||.......|. . ...|..
gdgesrtvthyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy

GQLLQFE
 .| ...
rflyeal
subfamily_PTPMT1_pd Subfamily PTPMT1 223-310 1e-17 59.1 In-house 80-167 (171) alignment 
Range on Protein: 223-310
Range on HMM: 80-167/171.0
PVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
.. |       .  .... ||. |...| || |||.|| .||||.  .|||..... ..|| ...|..|  |  .   . .| ..|..
atvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
0047943 (Phosphotyrosine protein) phosphatases II 216-306 1.2e-15 53.1 In-house 170-266 (273) alignment 
Range on Protein: 216-306
Range on HMM: 170-266/273.0
LFRYKSIPveDNQMVEISAWFQEAIGFIDWVKN---SGGRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQ
 | |...|  |..  .  . . | | ... . .   |.| |.||| ||..|..|.....|.       ..| ..||. .....|  . ...... .| .
hfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
subfamily_MSG5_pd Subfamily MSG5 241-310 3e-15 49.7 In-house 90-159 (165) alignment 
Range on Protein: 241-310
Range on HMM: 90-159/165.0
GFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQ
  |   .  . ..||||| |.||||.. .||.|.   . | .|.| .| .   |||.. .. ||...|. 
riihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva
0051299 (Phosphotyrosine protein) phosphatases II 217-300 7.7e-14 47.3 In-house 187-274 (288) alignment 
Range on Protein: 217-300
Range on HMM: 187-274/288.0
FRYKSIPveDNQMVE-ISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISPNFSF
| |...|  |... . ......    .... ...|| |.||| ||..|..|.....|.     . ..| . ||. .....|  . .... 
fhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
0046845 (Phosphotyrosine protein) phosphatases II 217-298 1.2e-12 43.2 In-house 170-260 (284) alignment 
Range on Protein: 217-298
Range on HMM: 170-260/284.0
FRYKSIPveDNQMVEISAWFQEAIGFIDWVKNS---GGRVLVHCQAGISRSATICLAYLMQSR--------RVRLDEAFDFVKQRRGVISPNF
| |.|.|  |..  . .....| . ... . ..   || ..||| ||..|..|.....|. ..        .| . ||. .....|     ..
fhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0050432 (Phosphotyrosine protein) phosphatases II 236-298 1.3e-12 43.2 In-house 216-285 (308) alignment 
Range on Protein: 236-298
Range on HMM: 216-285/308.0
FQEAIGFIDWVKNS--GGRVLVHCQAGISRSATICLAYLM-----QSRRVRLDEAFDFVKQRRGVISPNF
... . |...|..|  || ..||| ||..|..|.....|.     . ..| . ||. .....|    ...
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
Rhodanese Rhodanese-like domain 18-136 7.8e-11 34.5 Pfam-A 5-111 (113) alignment 
Range on Protein: 18-136
Range on HMM: 5-111/113.0
LRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALlRRRARGPPAAVLACLLPDRALRTRLVRgelaRAVVLDegsasVAELRPDSPAHVLLAALLHE
| . .|.|. .|||.|.. .. . |.. |. ||.. | . |.  .    ||  |.... .    .    . || .         |    |..|||..|.|
lkellekekvvllDvRspeeyakghIpgAvnvpldsl.yprrdlffkdklaeeleesgkkldkdk....tvvvyc.....rsgnrsggaaalllalilke

trAGPTAVYFLRGGFDGFQ
  .| . ||.|.|||....
..lgyknvyvLdGGfeawk
PTPc_DSPc_SM00012 237-289 1.6e-08 30.0 In-house 20-81 (105) alignment 
Range on Protein: 237-289
Range on HMM: 20-81/105.0
QEAIGFIDWVKNSG------GRVLVHCQAGISRSATICLAYLMQSRRVR---LDEAFDFVKQ
.. . ... ||..       . |.|||.||..|..|....... ..  .    .. |..||.
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivke
0048567 (Phosphotyrosine protein) phosphatases II 235-291 2.9e-08 28.2 In-house 59-118 (157) alignment 
Range on Protein: 235-291
Range on HMM: 59-118/157.0
WFQEAIGFIDWVKNSGGRVLVHCQAGI---SRSATICLAYLMQSRRVRLDEAFDFVKQRR
... .  |...... |... ||| ||    .|.||.. .||.   .   .||...... |
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_CDC14_pd Subfamily CDC14 242-301 8.4e-08 26.4 In-house 255-316 (328) alignment 
Range on Protein: 242-301
Range on HMM: 255-316/328.0
FIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRR-G-VISPNFSFM
|.. .... | . |||.||. |  |.  .|||.  |.   ||  ...  | | ||.|  .|.
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfl
subfamily_PTPDC1_pd Subfamily PTPDC1 246-292 4.2e-07 24.6 In-house 111-156 (182) alignment 
Range on Protein: 246-292
Range on HMM: 111-156/182.0
VKNSGgRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRG
. . | .| ||| ||  |   .  .||. ..|.  ..| ..|...| 
alqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_PTEN_pd Subfamily PTEN 221-291 1.3e-06 23.5 In-house 84-156 (184) alignment 
Range on Protein: 221-291
Range on HMM: 84-156/184.0
SIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVL-VHCQAGISRSATICLAYLMQSRRVRLD-EAFDFVKQRR
 .|..|..  ...   .      .|....  .|  |||.||  |. ..  |||..|. ..   || .. .. |
vypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
Y_phosphatase Protein-tyrosine phosphatase 238-279 2.2e-06 22.7 Pfam-A 154-199 (235) alignment 
Range on Protein: 238-279
Range on HMM: 154-199/235.0
EAIGFIDWVKNSG----GRVLVHCQAGISRSATICLAYLMQSRRVR
. . .|. |..|     | |.||| ||..|..|.... .. ..  .
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea
Y_phosphatase Protein-tyrosine phosphatase 238-279 2.2e-06 22.7 In-house 154-199 (235) alignment 
Range on Protein: 238-279
Range on HMM: 154-199/235.0
EAIGFIDWVKNSG----GRVLVHCQAGISRSATICLAYLMQSRRVR
. . .|. |..|     | |.||| ||..|..|.... .. ..  .
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 238-269 3.3e-06 21.5 In-house 179-210 (290) alignment 
Range on Protein: 238-269
Range on HMM: 179-210/290.0
EAIGFIDWVKNSGGRVLVHCQAGISRSATICL
 ..  |. ||.|.  |.|||. ||||||..  
tllsliqkvkasktpvivHcvdGiSrsAalaa
DSPc_SM00195 240-275 7.4e-06 20.8 In-house 181-220 (263) alignment 
Range on Protein: 240-275
Range on HMM: 181-220/263.0
IGFIDWVKNS----GGRVLVHCQAGISRSATICLAYLMQS
. ..  ||.|     | ..|||.||..|..|.... .. |
lellravkkskstssgpivVhCsaGvgRtgtfvtidiils
PTPc_SM00194 240-275 7.4e-06 20.8 In-house 181-220 (263) alignment 
Range on Protein: 240-275
Range on HMM: 181-220/263.0
IGFIDWVKNS----GGRVLVHCQAGISRSATICLAYLMQS
. ..  ||.|     | ..|||.||..|..|.... .. |
lellravkkskstssgpivVhCsaGvgRtgtfvtidiils
subfamily_Laforin_pd Subfamily Laforin 219-291 7.7e-06 18.9 In-house 79-151 (183) alignment 
Range on Protein: 219-291
Range on HMM: 79-151/183.0
YKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRR
|  .|.||         . .|. ..  . . | .| |||.||. ||..|   .|.      |     |.  .|
yiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr