Gene DUSP4 in Homo sapiens

Synonym: HVH2, MKP-2, MKP2, TYP, DUSP4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP011_AA protein Get Run
HsapP011_AA_193-337 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 180-337 4.8e-74 241.9 In-house 4-159 (163) alignment 
Range on Protein: 180-337
Range on HMM: 4-159/163.0
DLGCSSCGTPLHDqggPVE-ILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLV
.|||... ..|.|   ||| ||.||||||...|.....|..|||||.||||....|.|| ...||....||..|||||..|.|.||.||.||...|.||.
wlgcdldklklyd...PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvli

HCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT
|||||||||.|.||||||..|||.|||||.||||||||||||..|..|||..|...|..
hCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP10_pd Subfamily DSP10 196-334 1.8e-54 177.9 In-house 14-153 (159) alignment 
Range on Protein: 196-334
Range on HMM: 14-153/159.0
PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEG-HYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAY
 ...||||.|||.  ||  |.|| |.|||.||| ...||.||. . .|| |||.|..| ...  | ||.|.|. .. .  |||||||||||||||. .||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
|| .... |..|..|||..|.|||||..||||||.|| ..
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
subfamily_DSP6_pd Subfamily DSP6 195-334 4.7e-53 172.9 In-house 13-154 (158) alignment 
Range on Protein: 195-334
Range on HMM: 13-154/158.0
GPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGH--YQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICL
 ||||||.|||||| .|. ...|. |.|  .||| |. || || .   .|. ||.||.........| ||||.||  .     ||||| |||||| |..|
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

AYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
|||| |. . |..|...||.|.| |||||.||||||.||...
aylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
PTPc_motif_SM00404 196-332 4.4e-47 154.5 In-house 2-139 (140) alignment 
Range on Protein: 196-332
Range on HMM: 2-139/140.0
PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPN-HFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAY
| .||| |||||...| ....|..||||. .||.. ...   . ..|...||..||.|...| .. .....|..... .|.||||||||.|||||...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFES
||... . |.||.||||.||.|||||..|. ||...| 
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
DSPc Dual specificity phosphatase, catalytic domain 203-332 4.5e-46 151.0 Pfam-A 1-132 (133) alignment 
Range on Protein: 203-332
Range on HMM: 1-132/133.0
LYLGSAYHAArRDMLDALGITALLNVSSDCPN-HF--EGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKK
|||||...|   ..|..||||. .||.. .|| ..  .....| .|||||.....||... ||.|.|..... ...||||||||||||||...||||..|
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RVRLEEAFEFVKQRRSIISPNFSFMGQLLQFES
...|.||.||||.|||.||||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 203-332 4.5e-46 151.0 In-house 1-132 (133) alignment 
Range on Protein: 203-332
Range on HMM: 1-132/133.0
LYLGSAYHAArRDMLDALGITALLNVSSDCPN-HF--EGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKK
|||||...|   ..|..||||. .||.. .|| ..  .....| .|||||.....||... ||.|.|..... ...||||||||||||||...||||..|
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RVRLEEAFEFVKQRRSIISPNFSFMGQLLQFES
...|.||.||||.|||.||||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer
0044763 (Phosphotyrosine protein) phosphatases II 185-335 1.1e-45 150.8 In-house 12-171 (178) alignment 
Range on Protein: 185-335
Range on HMM: 12-171/178.0
SCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGH---------YQYKCIPVEDNHKADISSWFMEAIEYIDAVK-DCRG
  |..  |. ...||||.|||||...|. ...| .||||...|........|...         .||..||..|..  |....|.|..|.|...  .. |
leglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekgg

RVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSiISPNFSFMGQLLQFESQVL
.|||||.||..||.|...||||.| .. ||||.|.|..||. |.||.... ||..||...|
pvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP8_pd Subfamily DSP8 194-335 1.2e-44 145.6 In-house 13-155 (159) alignment 
Range on Protein: 194-335
Range on HMM: 13-155/159.0
GGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNH-FEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICL
 || .||..|||||  ..  ...|..|||.  ||.|  ||.  .  . ..  .||.|... ... || ...|.|| .|   ||||||. ||||||||. .
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
||.| . .. |.||..|||..|  ||||. |.||||..| .. 
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP19_pd Subfamily DSP19 198-334 3.3e-43 141.6 In-house 14-150 (152) alignment 
Range on Protein: 198-334
Range on HMM: 14-150/152.0
EILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMM
|. | |||||   || ...|.  .|| .|||. . ||.|  ...|..|.. |. ..|..|.. ||...|. ...  |.|||||.||.||||.. .|||| 
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

KKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
|....||||.| |.. |  |.||  |. || ..|...
keelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP14_pd Subfamily DSP14 197-340 7.3e-42 137.0 In-house 8-150 (157) alignment 
Range on Protein: 197-340
Range on HMM: 8-150/157.0
VEILPFLYLGsAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLM
..| | |.|. .. | ....|.. .||. .||. . ||.   . ..  .|||||..|.....| |....|..||   |..|||| ||.||||..||||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

MKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCA
  ... |.||.. ||..|.||.||  |  || ..|... ..|  
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssv
PTEN_1 176-337 3.7e-40 132.8 In-house 17-194 (196) alignment 
Range on Protein: 176-337
Range on HMM: 17-194/196.0
TEPLDLGCSSCGTP----LHDQGGPVEILPFLYLGSAYHAAR-RDMLDALGITALLNVSSDCPN---------HFEGHYQYKCIPVEDNHKADISSWFME
||.|||.... .        ..... || ..||.||. ..|. .|.|.. |||...|.|.....         .|.....|. .|.|| .. ..|..| .
telldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdi

AIEYIDAVK--DCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT
. . |....  .... |||||.||..||.|.. |||| |..   .||.|.|...|. ..|| ... .||..... || 
cksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0048076 (Phosphotyrosine protein) phosphatases II 194-334 1.1e-39 130.7 In-house 2-142 (145) alignment 
Range on Protein: 194-334
Range on HMM: 2-142/145.0
GGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLA
..| |||| ||||| ..| ....|  ||||..||..|....... ..|| ..|..|..  |......|..|.|... .  |.|||||.||..|..|...|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
|||....| ||||.|.|...|... ||.... .|..|| ..
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0043147 (Phosphotyrosine protein) phosphatases II 191-335 3.3e-38 126.5 In-house 14-161 (172) alignment 
Range on Protein: 191-335
Range on HMM: 14-161/172.0
HDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSD---CPNHFEGHYQYKCIPVEDNHKAdISSWFMEAIEYIDA--VKDCRGRVLVHCQAGIS
.    | .......... ..|  ..||  ||||...|. .    ... ..  .|| ..|..|..   ......|..|.||   ...  |.||||| ||..
dlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvg

RSATICLAYLMMkKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
|..|...||||. ... ||||...|...|.....|.|.. .|..||...|
Rtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0048179 (Phosphotyrosine protein) phosphatases II 195-333 1.1e-37 124.3 In-house 3-143 (144) alignment 
Range on Protein: 195-333
Range on HMM: 3-143/144.0
GPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY--QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICL
 |.|||| ||||| ..| . ..| .||||...|........|....  || ..|..|..  |..... |..|.|... .  |.|||||.||..|..|...
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQ
||||.|... ||||...|..||... ||.... .||..|..
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_Slingshot_pd Subfamily Slingshot 196-336 1.7e-37 122.4 In-house 19-159 (169) alignment 
Range on Protein: 196-336
Range on HMM: 19-159/169.0
PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYL
. .|  ..|||| . |.  . |.  |.. .|||. .. |.|.....|. | | |....|. ... |. ..|...|.   .|||||. |.||||.. .|| 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLA
| . .. ||||.|.||.|||.| || .|. || ..|  . |
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGilea
subfamily_DSP12_pd Subfamily DSP12 198-332 3.8e-36 118.8 In-house 4-141 (155) alignment 
Range on Protein: 198-332
Range on HMM: 4-141/155.0
EILPFLYLGSAYHAARRDMLDALGITALLNVSSDC-PNH--FEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAY
.||| ||||.. .... ..|. |.||..| | .   |.|   .|. ..| |.. |. ..|| |.. ||...|.   . .| ||||||||.|||.||..||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFES
|| |... ||.|...||. .. |.|| .|. ||  || 
lmkkeklslekAlklvkekkpeiepNegFleQLklfek
0041856 (Phosphotyrosine protein) phosphatases II 193-332 4.1e-35 116.4 In-house 16-170 (182) alignment 
Range on Protein: 193-332
Range on HMM: 16-170/182.0
QGGPVEILPFLYLGSAYH--------------AARRDMLDALGITALLNVSsdCPNHFEGHY-----QYKCIPVEDNHKADisswFMEAIEYIDAVKDCR
  .. .|.. ||||| ..              |.  .||  ||||...|..  .....  ..     ||...|..|..  |    . |....|..|..  
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeg

GRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRS--IISPNFSFMGQLLQFES
|.||||| ||..|..|...||||.|..| ||||...|..||.  .|.||. |. ||. .| 
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel
0049772 (Phosphotyrosine protein) phosphatases II 202-333 5.4e-35 117.0 In-house 155-272 (314) alignment 
Range on Protein: 202-333
Range on HMM: 155-272/314.0
FlylgSAYHAARRDMLDalgitallnvsSDC--PNHFEGH-YQYKCIPVEDnHKADISSWFMEAIEYIDAVkDCRGRVLVHCQAGISRSAT-ICLAYLMM
.    . ..||. ..|            . .  |..||.. ..|..|||.| . |.....| |..|.|... |  |.|||||.||..|..| ...||||.
g....neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmk

KKRVRLEEAFEFVKQRRSiISPNFSFMGQLLQFESQ
. .| ||||.|.|...|. |.||..|. ||.|.| .
llgvsleealedvrlkRp.inpnpgfieqleqyefi
subfamily_DSP3_pd Subfamily DSP3 198-334 8.3e-35 113.8 In-house 13-157 (162) alignment 
Range on Protein: 198-334
Range on HMM: 13-157/162.0
EILPFLYLGSAYHAARRDMLDALGITALLNVSSDC-------PNHFE-GHYQYKCIPVEDNHKADISSWFMEAIEYID-AVKDCRGRVLVHCQAGISRSA
|. | ||.| .. |  .. | .|||| .|| .          .....  . .|  ..|.|. ..|.| .| .| ..|| |... .|.|||||..|.||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TICLAYLMMKKRVRLEEAFEFVKQRRSIiSPNFSFMGQLLQFESQV
|. |||||..... | || . |...|.|  ||  |. || ......
tlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeel
0045098 (Phosphotyrosine protein) phosphatases II 180-334 1.4e-34 115.2 In-house 6-271 (278) alignment 
Range on Protein: 180-334
Range on HMM: 6-271/278.0
DLGCSSCGTPLHDQGGPVEILPFLYLGSAY-----------------------------------------HAARRDMLDALGITALLNVS---------
.| ... .  |. .| | ||.|.||||...                                         .|.  .||  ||||.....          
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

-------------------------------------------SDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKD--------------C
                                           .|.....  |..|...|  . .  .|...| |..|.|... .               
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

RGRVLVHCQAGISRSATICLAYLMMKK---RVRLEEAFEFVKQRRSI-ISPNFSFMGQLLQFESQV
 |.|||||.||..|..|...||||..    .| |.||.......| . . .|.... .| .|. ..
ggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 196-337 3.6e-34 112.0 In-house 120-261 (263) alignment 
Range on Protein: 196-337
Range on HMM: 120-261/263.0
PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCI-PVEDNHKADISSWFMEAIEYIDAVKDcRGRVLVHCQAGISRSATICLAY
| ||.. |.||.   |  . .|  ||.| .|   .|.   |   ..|  |  .||  .|||| .| |   .|.  .. .| |||||.||.|||.|. ..|
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsrsstlvisy

LMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT
||.|.|....||...|...|. | ||  |. ||...| .. .|
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfct
0049260 (Phosphotyrosine protein) phosphatases II 195-332 8.3e-34 111.8 In-house 7-147 (152) alignment 
Range on Protein: 195-332
Range on HMM: 7-147/152.0
GPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNH---FEGHYQYKCIPVEDNHKADISSWFMEAIEYIDA-VKDCRGRVLVHCQAGISRSATI
 | |.......|.  .|   .||  ||||..... ......   .| ..||...|..|..  |.| ....... |.   .|  |.||||| ||..|..|.
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

CLAYLMMkKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFES
..||||. ..| ||||...|...|... ||.... .|..||.
vaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_DSP15_pd Subfamily DSP15 198-335 2e-33 109.6 In-house 4-140 (151) alignment 
Range on Protein: 198-335
Range on HMM: 4-140/151.0
EILPFLYLGSAYHAARRDMLDALGITALLNVSSdCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMM
..|| ||||    .  ...|.   || .|.|.   ....  . .||||...|  .|..|..| |..|.| . .   . ||||| ||.|||.|.. |||| 
kvlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

KKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
   .  ..|.|..|..||.  ||| |  || ..| . |
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektkl
subfamily_MKPLT_pd Subfamily MKPLT 202-335 3.7e-33 108.4 In-house 28-161 (164) alignment 
Range on Protein: 202-335
Range on HMM: 28-161/164.0
FLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRV
 |||| | ||  . .|..| ||  .||| .. . |    .|  . |||. .  .||..  | ...    |  |||||||. | |||... .|.|.  |. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

RLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
 |.||.|..|.||||..||  |. || .||  .|
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 202-335 3.7e-33 108.4 In-house 28-161 (164) alignment 
Range on Protein: 202-335
Range on HMM: 28-161/164.0
FLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRV
 |||| | ||  . .|..| ||  .||| .. . |    .|  . |||. .  .||..  | ...    |  |||||||. | |||... .|.|.  |. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

RLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
 |.||.|..|.||||..||  |. || .||  .|
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 196-332 6.6e-33 107.3 In-house 7-145 (148) alignment 
Range on Protein: 196-332
Range on HMM: 7-145/148.0
PVEILP-FLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQ-YKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLA
| || . ||.|||  .||  ..| |||.|.. | . ...| .. .   |  ....|. | |.|. | ..|.... .||  .|||||.| |.|||. . |.
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFES
.|.  ||| |.||...||..|  . ||  |. || ..| 
wlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0046846 (Phosphotyrosine protein) phosphatases II 190-334 1.1e-32 108.5 In-house 6-172 (176) alignment 
Range on Protein: 190-334
Range on HMM: 6-172/176.0
LHDQGGPVEILPFLYLGSAY----------HAARRDMLDALGITALLNVSSDC-----------PNHFEGHYQYKCIPVEDNHKADIsSWFMEAIEYIDA
|........|.. |.|||..          .|.  .||  |||||..|. ..            |   . ..||...|..|..  |. ....|..|.|. 
lgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefire

VKDCRGRVLVHCQAGISRSATICLAYLMMK-KRVRLEEAFEFVKQRRS-IISPNFSFMGQLLQFESQV
. .  |.|||||.|||.|..|...|||... | . .|||...|...|.  . ...... .| .|| ..
alkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0036282 (Phosphotyrosine protein) phosphatases II 196-333 1.6e-30 101.4 In-house 12-168 (174) alignment 
Range on Protein: 196-333
Range on HMM: 12-168/174.0
PVEILPFLYLGSAYHAaRRDMLDALGITALLNVSSDCPNH---------------FEGHYQYKCIPVEDNHKADISSwFMEAIEYIDAVKDC--RGRVLV
 ..|.| |..|.. .|   .||  ||||..... . ....                . ..||...|..|..  |.|  . |...... .      | |||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCQAGISRSATICLAYLMMKKRV-RLEEAFEFVKQRR---SIISPNFSFMGQLLQFESQ
|| ||..|..|...||||..    .|..|...|...|   . . ...|.. .| .||..
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0040439 (Phosphotyrosine protein) phosphatases II 192-334 1.2e-29 99.1 In-house 25-245 (249) alignment 
Range on Protein: 192-334
Range on HMM: 25-245/249.0
DQGGPVEILPFLYLGSAYHAARRD------------------------MLDALGITALLNVSSDCPN---------------------------------
     ..||| |.|.. ..|   |                        ||  ||||......|....                                 
hsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddy

----------HFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKD------CRGRVLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQR
           .  ......|.. | .  .....| .....|.||..      . |.||||| ||..|..|...||||      ...| ||||.......
tvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsq

RSIISPNFSFMGQLLQFESQV
|. . .|.... .|.... . 
Rpgavqnpeqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 196-333 1.2e-29 99.0 In-house 39-240 (243) alignment 
Range on Protein: 196-333
Range on HMM: 39-240/243.0
PVEILPFLYLGSA--------YHAARRDMLDALGITALLNVSSDC---------------------------------------------PNHFEGHYQY
 ....| |.....        ..|.  .||  ||||..... ...                                             ....  ...|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

KCIPVED----NHKADISSWFMEAIEYIDA-----VKDCRGRVLVHCQAGISRSATICLAYLMMKK-RVRLEEAFEFVKQRRSI-ISPNFSFMGQLLQFE
 ..|. |    .. .|. ... |..|.|..     . |  |.||||| ||..|..|...||||... .| ||||.......|.  . ...|.. .| ...
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

SQ
 .
le
subfamily_STYXL1_pd Subfamily STYXL1 196-335 7e-29 94.1 In-house 11-154 (157) alignment 
Range on Protein: 196-335
Range on HMM: 11-154/157.0
PVEILP-FLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQ---YKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATIC
|||.|| .||||   .|  . .   | . | .|||.|. . ..|  .      |.|||. .||. . . ||...|.  |     |||  . ||||||.. 
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

LAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
.|||| .|.. |..|....|. .. . || .|. || ..| |.|
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0045450 (Phosphotyrosine protein) phosphatases II 201-334 4.8e-28 94.2 In-house 95-303 (307) alignment 
Range on Protein: 201-334
Range on HMM: 95-303/307.0
PFLYLGSAYHAARR----------------DMLDALGITALLNVSSDCPN-----------------------------HfEGHYQYKCIPVEDN-----
|.|.|.. |.  |.                 ||  .|.|...........                             | ...|.. ...|.|.     
pllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtge

------------HKADISSWFMEAIEYIDAVKD------CRGRVLVHCQAGISRSATICLAYLMMKKR--------VRLEEAFEFVKQRRSIISPNFSFM
               .....| |... |..|..      . |.||||| ||..|..|...||||.. .        | |.||.......|. . .|....
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

GQLLQFESQV
 .| ... . 
rflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 198-333 1e-27 92.5 In-house 49-241 (245) alignment 
Range on Protein: 198-333
Range on HMM: 49-241/245.0
EILPFLYLGSAYHAARRD----MLDALGITALLNVSSDCPNHFEGHY----------------------------------------------QYKCIPV
.| | ...... ..   .    ||  ||||........ ...... .                                              .| ..|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

EDNHKADISSWFMEAIEYIDAVKD--CRGRVLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQ
.|.. .|..... ...|... .      |.||||| ||..|..|...||||       ..| ||||.......|. . ...|.. .| ... .
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 198-329 4.1e-26 86.8 In-house 10-148 (151) alignment 
Range on Protein: 198-329
Range on HMM: 10-148/151.0
EILPFLYLGSAYHAARRDMLDALGITALLNVSS-----DCPNHFEG-HYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDC-RGRVLVHCQAGISRSATI
 . ..||.... .|.  ..|  |||.. .|. |      ||. ..    ....||..|..  ... .| ...|..... |.  | ||||| ||..|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

CLAYLMMkKRVRLEEAFEFVKQRRS-IISPNFSFMGQLLQ
...|||.  .| ||||.|.....|  .. ||  |. ||..
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 202-334 2e-25 82.9 In-house 9-152 (154) alignment 
Range on Protein: 202-334
Range on HMM: 9-152/154.0
FLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGH---------YQYKCIPVEDNHKADISSWFMEAIEYIDAVK--DCRGRVLVHCQAGISRSATI
|||..|   |  .  |.   |. .|||.   .| |  .         ..|  . . |. . ||   .  | |.||       ...||||...|.||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

CLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
 ..||| |... | .|.|..|. | ||.||  |. || .|| . 
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
0039614 (Phosphotyrosine protein) phosphatases II 217-334 5e-25 84.0 In-house 121-288 (297) alignment 
Range on Protein: 217-334
Range on HMM: 121-288/297.0
LDALGITALLNVSSDCPN--------------------------------------------HFEGHYQYKCIPveDNHKADISSWFMEAIEYIDAVKD-
.  .|.|..... . ...                                            ..  |.|| ..|  |..  .... ..|..|... .   
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrealae

--CRGRVLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
    |.||||| ||..|..|...||||      ...| ..||.......|. . ...|.. .| ... . 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_STYX_pd Subfamily STYX 198-337 1.2e-24 80.3 In-house 14-160 (166) alignment 
Range on Protein: 198-337
Range on HMM: 14-160/166.0
EILPFLYLGSaYHAARRDMLDA---LGITALLNVSSDCP-----NHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSAT
|||| |.||  | || .  |.     ||| .. .  .         |. ...|  . | ||   .|  .. .  |.||   .  |.|||| .|||||||.
eilpglflgp.ysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

ICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT
. .||.|    ..  ||| .|..||  |.||  |. || ..|.  || 
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylak
0040438 (Phosphotyrosine protein) phosphatases II 216-335 5.9e-24 80.3 In-house 105-276 (317) alignment 
Range on Protein: 216-335
Range on HMM: 105-276/317.0
MLDALGITALLNVSSDCPNH---------------------------FEGHYQYKCIPVEDN----------------HKADISSWFMEAIEYIDAVKDC
|.  .|.| .... . ...                             ...... ...|||.                   .. ... . .. ..||...
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----RGRVLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
     | ||||| ||..|..|...||||      ...| .|||.......|. . ...... .| ... . |
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0036941 (Phosphotyrosine protein) phosphatases II 199-335 3.7e-23 77.7 In-house 22-277 (297) alignment 
Range on Protein: 199-335
Range on HMM: 22-277/297.0
ILPFLYLGSAYHAARRD----------------------------------------------------------MLDALGITALLNVSSDCPNHF----
.||.|.||| ..|.. .                                                          |.  ...| ....... .. .    
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

------------------------------------------------EGHYQYKCIPvednhKADISSWFMEAIEYIDAVKD------CRGRVLVHCQA
                                                  |..|. .|       .. ... . ...|..|..        |.||||| |
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.....dhgvpespaslldfielvrkvlkllpsggpvlVHCsa

GISRSATICLAYLM--------MKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
|..||.|...|.||        . ..| . ||. .....|  . ...... .| ... . |
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0051429 (Phosphotyrosine protein) phosphatases II 201-337 5.8e-22 74.1 In-house 21-227 (272) alignment 
Range on Protein: 201-337
Range on HMM: 21-227/272.0
PF-LYLGSAY---HAARRDMLDALGITALLNVSSDCPNHFEG------HYQYKCIPVEDNHKADIS----------------------------------
|  ||....     ||  . |  |||.. ... |..   ...      . .| ..|..|..  .|.                                  
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------SWFMEAIEYIDAvkdcRGRVLVHCQAGISRSATICLAYLMMkKRVR--------------LEEAFEFVKQRRSIISPNFSFMG
                 ... |..|.. .     |.||||| ||..|..|.....|..  .|               |||| | ....|  . ..  .. 
evmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLLQFESQVLAT
.|.... ..| .
flyeallellrs
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 203-334 4.3e-21 68.5 In-house 6-141 (145) alignment 
Range on Protein: 203-334
Range on HMM: 6-141/145.0
LYLGSAYHAARRDMLDALGITALLNVSSDC----PNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMK
|| ||| ||    .|. |||. ..|...       .    ...   |  || .  |.|  | |  ..||  |.    |.||| ||.||| |. .|.||  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

KRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
  . | ||   |. .|    ||  |. .||..| |.
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0043336 (Phosphotyrosine protein) phosphatases II 224-331 1.2e-20 69.6 In-house 115-273 (278) alignment 
Range on Protein: 224-331
Range on HMM: 115-273/278.0
ALLNVS-----------------------------------------------SDCPNHFEGHYQYKCIPveDNHKA-DISSWFMEAIEYIDAVKDCRGR
 ....                                                 | . ..  ||.|...|  |..   ..|. .    . ..|..|. | 
tivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngp

VLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFE
||||| ||..|..|....||.       ..| ||||.......|  . ...|.. .| ...
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0038934 (Phosphotyrosine protein) phosphatases II 233-335 9.2e-20 66.6 In-house 72-177 (194) alignment 
Range on Protein: 233-335
Range on HMM: 72-177/194.0
PNHFEG-HYQYKCIPVEDNHKADISSWFMEAIEYIDA--VKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQ
|..||.  ..|  .|..| . .   .  .. .. .|    .|  | |.||| ||..|..|.. |||... .  .||| ......|  . || ... .||.
peefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

FESQVL
. ... 
rykelr
subfamily_PTPMT1_pd Subfamily PTPMT1 245-334 5.1e-18 60.1 In-house 79-168 (171) alignment 
Range on Protein: 245-334
Range on HMM: 79-168/171.0
IPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
... |  .|       ...|.|. |..   || |||.|| .||||.  .|||.|... .||| ...|..|.||  .   . .| ..|...
latvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0047943 (Phosphotyrosine protein) phosphatases II 233-329 1.1e-17 59.9 In-house 164-266 (273) alignment 
Range on Protein: 233-329
Range on HMM: 164-266/273.0
PNHFEGHYQYKCIPveDNHKADISSWFMEAIEYIDAVKD---CRGRVLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQRRSIISPNFSFM
  ..  |..|. .|  |..  .  . ..| ||... .       | |.||| ||..|..|.....|.     ....| ..||. .....|  . ......
esrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy

GQLLQ
 .| .
rflye
subfamily_MSG5_pd Subfamily MSG5 216-334 3.7e-16 52.7 In-house 42-160 (165) alignment 
Range on Protein: 216-334
Range on HMM: 42-160/165.0
MLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRS
. . | .  ..||. . ..        |   .| .|.. |   . .  . | | .  | ..||||| |.||||.. .||.|    . |..|.. .| .  
lkellsfdlvinvakeindlellvpavkyyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvad

IISPNFSFMGQLLQFESQV
 |||.. .. ||...|  .
dispsiglifqlmeweval
0051299 (Phosphotyrosine protein) phosphatases II 234-322 2.1e-15 52.4 In-house 181-273 (288) alignment 
Range on Protein: 234-322
Range on HMM: 181-273/288.0
NHFEGHYQYKCIPveDNHKADISSWFMEAIEYIDAV-KDCRGRVLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQRRSIISPNFS
 ..  |..|. .|  |..  |  . ... ..... . ... | |.||| ||..|..|.....|.      ...| ..||.......|  . ....
srtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 231-321 1.5e-14 49.6 In-house 161-260 (284) alignment 
Range on Protein: 231-321
Range on HMM: 161-260/284.0
DCPNHFEGHYQYKCIPveDNHKADISSWFMEAIEYIDAVKDC---RGRVLVHCQAGISRSATICLAYLMMKK--------RVRLEEAFEFVKQRRSIISP
. . ..  |..|. .|  |..  . .....| ..... . .     | ..||| ||..|..|.....|...         .| ..||. .....|     
tgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq

NF
..
tl
0050432 (Phosphotyrosine protein) phosphatases II 234-321 5.1e-14 47.8 In-house 196-285 (308) alignment 
Range on Protein: 234-321
Range on HMM: 196-285/308.0
NHFEGHYQYKCIPveDNHKADISSWFMEAIEYIDAVKdCRGRVLVHCQAGISRSATICLAYLM-----MKKRVRLEEAFEFVKQRRSIISPNF
 ..  |..|.  |  | .  .  . ... .|... .    | ..||| ||..|..|.....|.     ....| ..||. .....|    ...
srtvthfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
Rhodanese Rhodanese-like domain 42-152 5.5e-13 41.4 Pfam-A 11-112 (113) alignment 
Range on Protein: 42-152
Range on HMM: 11-112/113.0
GGKCLLLDCRPFLAHSAGYILGSVNVRCNTIvrRRAKGSVSLEQILPAEEEVRARLRSGLysAVIVYDersprAESLREDSTVSLVVQALRRNAERTDIC
..|..|||.|.. ....|.| |.|||. ...  .  . . . ...    ||.  .| .     |.||.     . . |   . .|..... ...  ....
kekvvllDvRspeeyakghIpgAvnvpldsl..yprrdlffkdklaeeleesgkkldkdk..tvvvyc.....rsgnrsggaaalllalilkelgyknvy

LLKGGYERFSS
.|.||.| ...
vLdGGfeawka
PTPc_DSPc_SM00012 240-302 4.8e-11 38.2 In-house 3-68 (105) alignment 
Range on Protein: 240-302
Range on HMM: 3-68/105.0
YQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCR---GRVLVHCQAGISRSATICLAYLMMKKRVR
..|..    | .. . |. ..|...... .|  .   . |.|||.||..|..|..........  .
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqlek
0048567 (Phosphotyrosine protein) phosphatases II 252-323 1.1e-08 29.6 In-house 53-129 (157) alignment 
Range on Protein: 252-323
Range on HMM: 53-129/157.0
KADISSWFMEAIEYIDAVKDCRGRVLVHCQAGI---SRSATICLAYLMMKKRVRLEEAFEFVKQRR--SIISPNFSF
 | . .... . .... .. ..... ||| ||    .|.||.. .||... .   |||...... |  |.. .  |.
lailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasy
Y_phosphatase Protein-tyrosine phosphatase 227-310 1.9e-08 29.4 Pfam-A 122-209 (235) alignment 
Range on Protein: 227-310
Range on HMM: 122-209/235.0
NVSSDCPNH----FeGHYQYKCIPvEDNHKADiSSWFMEAIEYIDAVK-DCRGRVLVHCQAGISRSATICLAYLMMKKRVR--LEEAFEFV
...... ..    .  ...|.  | . . ... .. ... |. .   | ...| |.||| ||..|..|.... .....  .    . ...|
elkkkkeesekrev.kqlhytnWp.dhgvpes.pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv
Y_phosphatase Protein-tyrosine phosphatase 227-310 1.9e-08 29.4 In-house 122-209 (235) alignment 
Range on Protein: 227-310
Range on HMM: 122-209/235.0
NVSSDCPNH----FeGHYQYKCIPvEDNHKADiSSWFMEAIEYIDAVK-DCRGRVLVHCQAGISRSATICLAYLMMKKRVR--LEEAFEFV
...... ..    .  ...|.  | . . ... .. ... |. .   | ...| |.||| ||..|..|.... .....  .    . ...|
elkkkkeesekrev.kqlhytnWp.dhgvpes.pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv
subfamily_CDC14_pd Subfamily CDC14 264-324 2.4e-08 28.2 In-house 254-316 (328) alignment 
Range on Protein: 264-324
Range on HMM: 254-316/328.0
EYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRR--SIISPNFSFM
..........| . |||.||. |  |.  .||| . |.  .||  ...  |  |.|.|  .|.
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfl
DSPc_SM00195 239-300 3e-08 28.7 In-house 160-222 (263) alignment 
Range on Protein: 239-300
Range on HMM: 160-222/263.0
HYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDC-RGRVLVHCQAGISRSATICLAYLMMKKR
 .||..   .|.   |  . ..| .....  |.   | ..|||.||..|..|.... ....| 
vtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskl
PTPc_SM00194 239-300 3e-08 28.7 In-house 160-222 (263) alignment 
Range on Protein: 239-300
Range on HMM: 160-222/263.0
HYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDC-RGRVLVHCQAGISRSATICLAYLMMKKR
 .||..   .|.   |  . ..| .....  |.   | ..|||.||..|..|.... ....| 
vtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 239-302 2e-07 25.4 In-house 180-238 (307) alignment 
Range on Protein: 239-302
Range on HMM: 180-238/307.0
HYQYKCIPveDNhkaDISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVR
|.|..  |  |.    .    . ||. ..||.  .  |.||| ||. || ||    |.. | ..
hlqwenwp..dr...gvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmia
subfamily_PTPDC1_pd Subfamily PTPDC1 273-315 2.4e-07 25.4 In-house 114-156 (182) alignment 
Range on Protein: 273-315
Range on HMM: 114-156/182.0
RGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRS
.|.| ||| ||  |   .  .||. .||.  |.| ..|...|.
egkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_PTEN_pd Subfamily PTEN 242-315 1.5e-06 23.3 In-house 82-157 (184) alignment 
Range on Protein: 242-315
Range on HMM: 82-157/184.0
YKCIPVEDNHKADISsWFMEAIEYIDAV--KDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLE-EAFEFVKQRRS
 ...|..|.. . ..  . |..| |..   .| .  | |||.||  |. ..  |||. .. .. . || |. .. |.
vavypfdDhnppple.lleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_Ptp69D_pd Subfamily Ptp69D 240-312 3.6e-06 21.3 In-house 187-260 (307) alignment 
Range on Protein: 240-312
Range on HMM: 187-260/307.0
YQYKCIPveDNHKADISSWFMEAIEYI-DAVKDCRGRVLVHCQAGISRSATI-CLAYLMmkKRVRLEEA---FEFVKQ
|.|.  .  | .  . .   .. || . .  |  |. ..|||.|| .||... .|. |.  .....|.    ||.||.
yhytgWk..DskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsll..qqlkaedkvdifetvkd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 261-301 6.6e-06 20.5 In-house 179-219 (290) alignment 
Range on Protein: 261-301
Range on HMM: 179-219/290.0
EAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRV
 ... |. ||  .  |.|||. ||||||..    | . | .
tllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkia