Gene DUSP19 in Homo sapiens

Synonym: DUSP17, LMWDSP3, SKRP1, TS-DSP1, DUSP19

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP022_AA protein Get Run
HsapP022_AA_63-206 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP19_pd Subfamily DSP19 55-204 6.7e-70 228.3 In-house 1-150 (152) alignment 
Range on Protein: 55-204
Range on HMM: 1-150/152.0
GYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGV
|.|.||..||.||...|.|.|||||.|.| ..||..|.|||||||.||.|.| .||||.||.|||||||..|||..|...|||||..|||.|||||||||
gfveDlkedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGv

SRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGK
||.|..||..||..|..|...|..||..|||.|.||.||..||..|.. .
SRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP1_pd Subfamily DSP1 66-205 7.6e-45 146.9 In-house 18-157 (163) alignment 
Range on Protein: 66-205
Range on HMM: 18-157/163.0
VGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFL
|  |...| |||.  | .|..||....|.||||.  ..|.| . |.||.. . | |. .| ..| |  |||.|.|.|.| ||.||.||.||...... .|
vekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKE
|.....|.. || .||. |. | || ||. || .|..  .
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP10_pd Subfamily DSP10 67-202 1.6e-43 142.3 In-house 15-151 (159) alignment 
Range on Protein: 67-202
Range on HMM: 15-151/159.0
GVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLS-DFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFL
  . |.|.|||.  |.|||.|.. ..|..|||.  | | |   ...|| | . |  . |.  || | .||||||..|.  |||||.||.||.|..||..|
sqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYl

MNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
|.  . |.. |. .||..|| | || .|| ||  . .
mkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
subfamily_DSP12_pd Subfamily DSP12 68-206 4.1e-43 141.5 In-house 4-145 (155) alignment 
Range on Protein: 68-206
Range on HMM: 4-145/155.0
VIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGV---ENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGF
 |.| |.||.  |... ..||. |.||.| |.      ...  .  ..|.| ||| ||..|||...|...|||||  ..| |||||.||||| ..||| .
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKES
|| .|. |...|..|||...|.|.|| ||.|||. ... . .
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
subfamily_DSP6_pd Subfamily DSP6 69-202 2.9e-42 137.9 In-house 17-152 (158) alignment 
Range on Protein: 69-202
Range on HMM: 17-152/158.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLS--DFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLM
| | | |||...|..|..||| |. ..|||.  ..|.| .  ...|. |.| |  ..|. ..||| .|||.||..|.  ||||| ||.||. .... .||
ilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylm

NSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
.... |. .|. |||. ...| ||  ||.||  ...
kklalslndaydlvkkrksnisPnfnfmgqlldfer
subfamily_Slingshot_pd Subfamily Slingshot 69-203 2.4e-40 131.7 In-house 22-156 (169) alignment 
Range on Protein: 69-203
Range on HMM: 22-156/169.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNS
|  .. |||.  | .|. ||.|.|..||||.  ..| |  .|.|. |.. | .||..|.|. | ..|||.||.|.  |||||  ||||.|..|| . |..
ifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamke

EQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEG
 ..|. .|.. ||. |  | ||.||..||..|.  
yglsleealeyvkerrsvikPnkgflkqleeyeGi
0044763 (Phosphotyrosine protein) phosphatases II 65-202 2.9e-40 133.2 In-house 22-168 (178) alignment 
Range on Protein: 65-202
Range on HMM: 22-168/178.0
QVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSD---------FTYKSISILDLPETNILSYFPECFEFIEEAK-RKDGVVLVHCNAGV
 .  | | |.|||. .|.||. ||....|||.|..  .|. ||..         ..|. | | | .....|..|.|..||||||  .|.|.|||||.|||
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRAAAIVIGFLMNSEQTSFTSAFSLVKNARPsICPNSGFMEQLRTYQE
.|....|. .|| . . |. .|..||...|| |.|| |...||. ...
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefel
subfamily_DSP14_pd Subfamily DSP14 66-208 4.4e-39 128.0 In-house 7-148 (157) alignment 
Range on Protein: 66-208
Range on HMM: 7-148/157.0
VGVIKPWLLLGsQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFL
.  |.|.| |.   || . ..|||.|.|.|.||.  . |  |.|. .  . . | ||... ..| |  . |||.|.|.| .|||| ||||| |.... .|
lsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNK
|. |..|   |..|||.||| |.||.|| .||..| .  . ..
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
PTPc_motif_SM00404 69-201 2.1e-37 123.1 In-house 5-138 (140) alignment 
Range on Protein: 69-201
Range on HMM: 5-138/140.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVEN-AFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMN
| | | |||...| ... |||...||..||.  |..    |.|....| . |  ..... |.... .|||.|..| | ||||| ||||| |...| .||.
ilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr

SEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
..| |  .|...||. ||.|.|| .|..||  |.
yrqlslaeayefvkerRpiispnlnfvrqLieye
0048076 (Phosphotyrosine protein) phosphatases II 68-201 6.6e-36 118.5 In-house 6-139 (145) alignment 
Range on Protein: 68-201
Range on HMM: 6-139/145.0
VIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMN
 | | | |||. .|.||..||....|..||...  |. .  ...|  ... | .. ..|....|..|||||| ...|.|||||.|||.|....|. .|| 
eilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylml

SEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
... |. .|. ||...|| ..|| |....|. ..
llgvsleealelvrsqrpgavpnpgqlrflyefe
DSPc Dual specificity phosphatase, catalytic domain 74-202 1.2e-35 117.3 Pfam-A 2-132 (133) alignment 
Range on Protein: 74-202
Range on HMM: 2-132/133.0
LLGSQDAAHdLDTLKKNKVTHILNVAYGVENAF---LSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQ
 |||. .|  |. |.|...|...||.  |.|..    |...| .| . |  ||.| ....|. ||||.|..| . |||||.||.|| |...| .||....
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

TSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
 | ..|...||. |..|.|| ||. ||. |..
lslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 74-202 1.2e-35 117.3 In-house 2-132 (133) alignment 
Range on Protein: 74-202
Range on HMM: 2-132/133.0
LLGSQDAAHdLDTLKKNKVTHILNVAYGVENAF---LSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQ
 |||. .|  |. |.|...|...||.  |.|..    |...| .| . |  ||.| ....|. ||||.|..| . |||||.||.|| |...| .||....
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

TSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
 | ..|...||. |..|.|| ||. ||. |..
lslneAyefvkerrskispnagflrqLleyer
subfamily_LRR-DSP_pd Subfamily LRR-DSP 69-202 1.3e-35 116.8 In-house 123-256 (263) alignment 
Range on Protein: 69-202
Range on HMM: 123-256/263.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSI-SILDLPETNILSYFPECFEFIEEAkRKDGVVLVHCNAGVSRAAAIVIGFLMN
| . | ||..|.| .   ||.. |||||     .|  |   | | ||  | | .| .|  .| |   ||||  || | ||||| |||||....|| .|| 
iidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeG.rkkGGvlvhcraGvsrsstlvisylmk

SEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
 ..  |  |. ||.. || | || ||..||. |..
kqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0048179 (Phosphotyrosine protein) phosphatases II 68-201 3.2e-35 116.3 In-house 6-141 (144) alignment 
Range on Protein: 68-201
Range on HMM: 6-141/144.0
VIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDF--TYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFL
 | | | |||. .|.||..|||...|...|.. . |..|| ..  .|  ... | .  ..|....|..|||||| ...|.|||||.|||.|....|. .|
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
|  .. |. .|. ||...|| ..|| |....|. |.
mkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 73-202 5.6e-35 113.9 In-house 10-150 (154) alignment 
Range on Protein: 73-202
Range on HMM: 10-150/154.0
LLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSD---------FTYKSISILDLPETNILSYFPECFEFIEEAK--RKDGVVLVHCNAGVSRAAAIV
| ..|.||| .   |.......||||. |..|.|  .         . |  . . | .. .|.  .  .||||..|    ... ||||...||||.||..
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

IGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
|..||.. . |.  |. |.|..|. | || ||..||  .. 
isylmdklkislslalellkdsryiikPnqGflkqleifek
subfamily_DSP15_pd Subfamily DSP15 69-213 2.1e-34 112.8 In-house 5-148 (151) alignment 
Range on Protein: 69-213
Range on HMM: 5-148/151.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYgVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNS
. | | ||    ..| . ||....||||.|    .. .| |..|| |.. | |.... ..| |. ||| ... |.. ||||| |||||.. .|. .||  
vlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv

EQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQ
 . ..  |.. .|.|| .  || || .||. |.. | ..  ....
telnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkqlk
PTEN_1 69-206 2e-32 107.6 In-house 45-193 (196) alignment 
Range on Protein: 69-206
Range on HMM: 45-193/196.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVEN---------AFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKR--KDGVVLVHCNAGVSRA
.. ...    |.| |||.||....|...|.. . |.         .| |...|....| | .  .. . | .| .||| ...  . .|||||| ||..| 
deglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRs

AAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKES
. .|. .|| ... ..  |..||. .|| ..|||...|.|. |..   .
GtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_DSP3_pd Subfamily DSP3 69-203 6.1e-32 104.5 In-house 14-156 (162) alignment 
Range on Protein: 69-203
Range on HMM: 14-156/162.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYG----V--ENAFLS--DFTYKSISILDLPETNILSYFPECFEFIEEAKR-KDGVVLVHCNAGVSRAAA
. | | .| ...|.| . |||  .||.|| | |    |  .. | .  ...|  . . | ||...  || . ..||.||   |.| |||||..||||.|.
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

IVIGFLMNSEQTSFTSAFSLVKNARpSICPNSGFMEQLRTYQEG
.|. .|| ... . ..| . |.. | .|.||.||..||....| 
lvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldee
0049772 (Phosphotyrosine protein) phosphatases II 66-202 3.2e-31 104.6 In-house 155-271 (314) alignment 
Range on Protein: 66-202
Range on HMM: 155-271/314.0
VgvikpwlllgSQDAAHDLDTLKknkvthilNVAYGVENAFLSDFTYKSISILDlPETNILSYFPECFEFIEEAkRKDGVVLVHCNAGVSRAA-AIVIGF
           ..  |.||..||        .. |  |      ..|. | . | .....|..|.|..|||||| .|.|.|||||.||..|.. ..|...
g..........neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaay

LMNSEQTSFTSAFSLVKNARPsICPNSGFMEQLRTYQE
||   . |.  |.. |...|| |.|| ||.|||. |..
lmkllgvsleealedvrlkRp.inpnpgfieqleqyef
0041856 (Phosphotyrosine protein) phosphatases II 67-203 3.3e-31 103.7 In-house 20-171 (182) alignment 
Range on Protein: 67-203
Range on HMM: 20-171/182.0
GVIKPWLLLGSQDA--------------AHDLDTLKKNKVTHILNVAygVENAFLSDF-----TYKSISILDLPETNilsyFPECFEFIEEAKRKDGVVL
  | . |.|||. |              |..|..||....|.|.|..   |. . ...     .|. ... | . ..    ..|...||||.....|.||
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARP--SICPNSGFMEQLRTYQEG
|||.|||.|....|. .|| . . |...|..||...||   |.|| .|..||  ... 
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
0043147 (Phosphotyrosine protein) phosphatases II 69-201 3.5e-31 103.6 In-house 22-157 (172) alignment 
Range on Protein: 69-201
Range on HMM: 22-157/172.0
IKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYG---VENAFLSDFTYKSISILDLPETnILSYFPECFEFIEE--AKRKDGVVLVHCNAGVSRAAAIVIG
. ... ... . |.... ||....|||.|.       |. . ....|  ... | . . .|....|..|||.|  |....|.||||| |||.|....|. 
fiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaa

FLMNsEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
.||  .. |.  |..||...|| ...| ... .|. ..
ylml.lglsleeavalvrekRpgavqnpsqyrflyyfe
0045098 (Phosphotyrosine protein) phosphatases II 54-201 4.9e-31 103.6 In-house 10-268 (278) alignment 
Range on Protein: 54-201
Range on HMM: 10-268/278.0
CGYVQDLSSDLQVGVIKPWLLLGSQD-----------------------------------------AAHDLDTLKKNKVTHILNVA-------------
. . . | .  ... | |.|.||..|                                         .|.....|.....|.|....             
llefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

---------------------------------------YGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKR--------------KDGVV
                                       .. |....  . |...   . |...||..| |..|||.|| .              ..|.|
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

LVHCNAGVSRAAAIVIGFLMNSE---QTSFTSAFSLVKNARPS-ICPNSGFMEQLRTYQ
||||.|||.|....|. .|| .    . .. .|.. ... ||  ...| .....|  ..
lVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefl
subfamily_DSP8_pd Subfamily DSP8 66-202 9.5e-31 100.5 In-house 15-152 (159) alignment 
Range on Protein: 66-202
Range on HMM: 15-152/159.0
VGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAY-GVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGF
.  | . | ||||  . . ..|.|. ....||.    ..  .|..  .  . . |  . ..| .|.. .|||. ||...| ||||. || ||.|...|..
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

LMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
.|   . |. .|.  ||. ||.| ||  |..||  |..
imktlemsldeayrfvkekrptispnlnflgqLleyek
0049260 (Phosphotyrosine protein) phosphatases II 70-201 9.7e-29 95.4 In-house 12-146 (152) alignment 
Range on Protein: 70-201
Range on HMM: 12-146/152.0
KPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENA---FLSDFTYKSISILDLPETNILSYFPECFEFIEE-AKRKDGVVLVHCNAGVSRAAAIVIGFL
 ... .|....|.... ||....|.|...   .|..   .   ..|. . . | .  ..  .......|||. |..|.|.||||| |||.|....|. .|
iatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

MNsEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
|   . |.  |..||...|| ..|| |....|  ..
ml.lgvsleeavalvrekRpgavpnpgqlrflyefe
subfamily_STYX_pd Subfamily STYX 68-202 2.1e-28 92.5 In-house 14-155 (166) alignment 
Range on Protein: 68-202
Range on HMM: 14-155/166.0
VIKPWLLLGSQDAAH--DLDTLKKNKVTHILNVAYGVENA-----FLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAI
 | | | ||   ||    |..|||. .|||. .   .| .     |  .| |  . . | .  ||. |.|.  |||... .| | |||| |||.||.||.
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

VIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
||...|..    . .||  |.. |  | ||.||..||. |. 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_MKPLT_pd Subfamily MKPLT 70-202 2.5e-28 92.7 In-house 26-158 (164) alignment 
Range on Protein: 70-202
Range on HMM: 26-158/164.0
KPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSE
.  | ||  . | .   ||. |.|||.||. .  .||   . |  ... | ..... |..    .|. .|    | |||||. |.||.... . ||..|.
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

QTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
.  .  |.. .|. |  . || ||. || ...|
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 70-202 2.5e-28 92.7 In-house 26-158 (164) alignment 
Range on Protein: 70-202
Range on HMM: 26-158/164.0
KPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSE
.  | ||  . | .   ||. |.|||.||. .  .||   . |  ... | ..... |..    .|. .|    | |||||. |.||.... . ||..|.
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

QTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
.  .  |.. .|. |  . || ||. || ...|
gwtlkeayeylkerrsivapnrGflkqlakfee
0040439 (Phosphotyrosine protein) phosphatases II 78-200 1.4e-27 92.3 In-house 65-241 (249) alignment 
Range on Protein: 78-200
Range on HMM: 65-241/249.0
QDAAHDLDTLKKNKVTHILNVAYGVEN-------------------------------------------AFLSDFTYKSISILDLPETNILSYFPECFE
.  ..... |.....|.|...   ||.                                            . ...|.. | ..|.|.... ..|.....
etvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlld

FIEEAKR------KDGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
|||...       |.|.|||||.|||.|...... .||        . .. .|..|....|| ...| .....|  .
fieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 70-201 1e-26 87.2 In-house 12-144 (148) alignment 
Range on Protein: 70-201
Range on HMM: 12-144/148.0
KPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFT-YKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNS
. .| |||.  | ||..||.  ||.| | .   .||.      |  ... | |. .. ..|..  .|...|| . . ||||.. ||||..|... .|.. 
dafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidf

EQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
.. |   |. |||..|. . || ||..||  ..
krvslkealalvkskrryvdpnlgfLkqLaele
0045450 (Phosphotyrosine protein) phosphatases II 85-200 5e-26 87.6 In-house 125-299 (307) alignment 
Range on Protein: 85-200
Range on HMM: 125-299/307.0
DTLKKNKVTHILNVAYGVENAF----------------------------LSDFTYKSISILDL-----------------PETNILSYFPECFEFIEEA
  |....||.|...   ||...                            |...|.  . . ||                 |.... ..| |...||||.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KR------KDGVVLVHCNAGVSRAAAIVIGFLMNSEQ--------TSFTSAFSLVKNARPSICPNSGFMEQLRTY
..      |.|.|||||.|||.|...... .|| .           .. .|..|... || ...| .....|. .
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0046846 (Phosphotyrosine protein) phosphatases II 64-200 1e-25 85.9 In-house 10-168 (176) alignment 
Range on Protein: 64-200
Range on HMM: 10-168/176.0
LQVGVIKPWLLLGSQD----------AAHDLDTLKKNKVTHILNVAYGVENAFLS-----------DFTYKSISILDLPETNIlSYFPECFEFIEEAKRK
| .  | . |.|||             |..|. ||....|...|.   || ..|.           ...|. . . |    .. ....|..|||.|| ..
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

DGVVLVHCNAGVSRAAAIVIGFLMNS-EQTSFTSAFSLVKNARP-SICPNSGFMEQLRTY
.|.||||| ||..|....|. .|. .  . |   |..||.. ||  . .. .....|. .
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
0036282 (Phosphotyrosine protein) phosphatases II 66-200 4.4e-25 83.8 In-house 12-165 (174) alignment 
Range on Protein: 66-200
Range on HMM: 12-165/174.0
VGVIKPWLLLGSQDAAhDLDTLKKNKVTHILNVAYGVENA---------------FLSDFTYKSISILDLPETNILSyFPECFEFIEEAKRK--DGVVLV
. .| | |..|.  .| ... ||....|.....   .|.                  ....|. . . |  . ..   . |...|.|||  .  .|.|||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCNAGVSRAAAIVIGFLMNSEQT-SFTSAFSLVKNAR---PSICPNSGFMEQLRTY
||.|||.|....|. .||   .  |.  |..||. .|   | .... .....|. .
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
subfamily_STYXL1_pd Subfamily STYXL1 67-202 1.4e-24 80.1 In-house 13-151 (157) alignment 
Range on Protein: 67-202
Range on HMM: 13-151/157.0
GVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFT---YKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIG
 |.   | ||    | .    |  ||   .||.   .. . ..        |.. | .|...|. . |  .|||. |... ||||  | |.||.||..|.
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviia

FLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQE
.|| |..... .|.. .|. .. ..|| .|.|||. ...
ylmyskkitlkkaykylkkCkenvkPnrafveqlseWek
0040438 (Phosphotyrosine protein) phosphatases II 86-200 2e-24 81.9 In-house 105-271 (317) alignment 
Range on Protein: 86-200
Range on HMM: 105-271/317.0
TLKKNKVTHILNVAYGVENA---------------------------FLSDFTYKSISILDL----------------PETNILSYFPECFEFIEEAKRK
 .....||.|...   .|.                             |...|.  . . ||                |. .. ... ....|.|.....
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----DGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
    .|.|||||.|||.|...... .||       .. ....|.  ....|| .... .....| ..
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0051082 (Phosphotyrosine protein) phosphatases II 64-200 4.9e-24 80.0 In-house 6-149 (151) alignment 
Range on Protein: 64-200
Range on HMM: 6-149/151.0
LQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDF------TYKSISILDLPETNILSYFPECFEFIEEAKRK-DGVVLVHCNAGVSR
.  . . . |.....  |..|..||......|.|.   .|.... ..      ... | ||| |....  .|... ||.|.. .| .|.|||||.||..|
infsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgR

AAAIVIGFLMNsEQTSFTSAFSLVKNARP-SICPNSGFMEQLRTY
 ...|. .||  .. |. .|.. ..  || ...|| .|. ||. .
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0037934 (Phosphotyrosine protein) phosphatases II 71-200 1.2e-23 79.4 In-house 44-237 (243) alignment 
Range on Protein: 71-200
Range on HMM: 44-237/243.0
PWLLLGSQ--------DAAHDLDTLKKNKVTHILNVAYGV---------------------------------------------ENAFLSDFTYKSISI
| | ....        |.|.... |.....|.|...   |                                             .. .. .. |  ...
prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpw

LD----LPETNILSYFPECFEFIEE-----AKRKDGVVLVHCNAGVSRAAAIVIGFLMNSE-QTSFTSAFSLVKNARPS-ICPNSGFMEQLRTY
 |       ...|... |. |||||     |  ..|.||||| |||.|...... .|| .  . .. .|. |... ||  .... .....|. .
pdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 68-200 1.9e-23 78.6 In-house 49-238 (245) alignment 
Range on Protein: 68-200
Range on HMM: 49-238/245.0
VIKPWLLLGSQDAAHDLD----TLKKNKVTHILNVAYGVENA----------------------------------------------FLSDFTYKSISI
 |.| ...... ......     |.....|.|...   .|.                                                . ...|  ...
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

LDLPETNILSYFPECFEFIEEAKR--KDGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
 | .....|... ...||...| .  ..|.|||||.|||.|...... .||          |. .|.  ... || .... .....|. .
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 69-200 1.1e-22 76.2 In-house 22-272 (297) alignment 
Range on Protein: 69-200
Range on HMM: 22-272/297.0
IKPWLLLGSQDAAHDLDTLKKN----------------------------------------------------------KVTHILNVAYGVENAF----
. |.||||| ..|. ...|.||                                                          .||.|...   ||. .    
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

---------------------------LSDFTYKSISILD----------------LPETNILSYFPECFEFIEEAKR------KDGVVLVHCNAGVSRA
                           |.|.|.  . ..|                 |. .. ... ....|||....      ..|.|||||.|||.|.
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

AAIVIGFLM--------NSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
..... .||          .. .. .|.  ... || .... .....|. .
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 85-200 1.1e-20 69.8 In-house 119-284 (297) alignment 
Range on Protein: 85-200
Range on HMM: 119-284/297.0
DTLKKNKVTHILNVAYGVEN--------------------AFLSDFTYKSISILDL-------------------PETN---ILSYFPECFEFIEEAKR-
  .....||.|...   ||.                     .|. .... . .  |                   |. .   .|... | .|...|| . 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--KDGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
  |.|.|||||.|||.|...... .||        . .. .|.. ....|| .... .....|. .
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0038934 (Phosphotyrosine protein) phosphatases II 91-205 2.7e-19 65.0 In-house 56-177 (194) alignment 
Range on Protein: 91-205
Range on HMM: 56-177/194.0
KVTHILNV-----AYGVENAFLSDFTYKSISILD---LPETNILSYFPECFEFIEeAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKN
|.......      | .|    ....| .. . |    | ..||  | .  ...  .. ..|||.||| ||..|.. .|. .|. . . |   |  |.. 
klglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfre

ARPSICPNSGFMEQLRTYQEGKE
.||.. || ...|.|... .  .
kRpgaipnqdyleallkrykelr
0051429 (Phosphotyrosine protein) phosphatases II 66-200 1.2e-17 60.0 In-house 16-220 (272) alignment 
Range on Protein: 66-200
Range on HMM: 16-220/272.0
VGVIKPWLLLGSQD----AAHDLDTLKKNKVTHILNVAYGVENAFLS------DFTYKSISILDLPETNILSYF--------------------------
 .|.|| .|. |.      |.|...||......|...   .| ..|       ...|  ..|||  .. || ..                          
grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltllls

----------------------PECFEFIEEAKRkDGVVLVHCNAGVSRAAAIVIGFLMNsEQTS--------------FTSAFSLVKNARPSICPNSGF
                       .. |..|.  . .| |||||.||..| . .|  .|.  .. |                 | . .. .|| . .. ..
agearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

MEQLRTY
...|. .
ylflyea
0043336 (Phosphotyrosine protein) phosphatases II 86-200 1.3e-16 56.4 In-house 107-272 (278) alignment 
Range on Protein: 86-200
Range on HMM: 107-272/278.0
TLKKNKVTHILNVA-----------------------------------------------YGVENAFLSDFTYKSISILDLPEtNILSYFPECFEFIEE
 .....||.|...                                                .  |  .   . |...   ..|| .. ...  . ...| 
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrea

AKRKDGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
 . ..|.|||||.|||.|...... .|.     .    .. .|.. ... ||.....  ....|. .
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 73-201 2.5e-16 53.1 In-house 6-138 (145) alignment 
Range on Protein: 73-201
Range on HMM: 6-138/145.0
LLLGSQDAAHDLDTLKKNKVTHILNVAYGVE----NAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNS
|. ||   |.|. ||..  .. |.|.| |      ..   ...   |.  ||   ..  .| |  .||.  | .   |.||| |||||. .. . |||  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

EQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
 . ... |   |.  |   .||  |. .|   .
cnmtlseaarqvrsnrllaypnvtflknllnle
subfamily_PTPMT1_pd Subfamily PTPMT1 114-203 8.5e-16 52.9 In-house 78-167 (171) alignment 
Range on Protein: 114-203
Range on HMM: 78-167/171.0
SISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEG
.... |  |.  |    .  ||||. . |   | |||.|| .|.|..|. .|| .|. |  .| . .|. |. |  ..  ...|. |.| 
qlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
0047943 (Phosphotyrosine protein) phosphatases II 90-197 8e-14 47.2 In-house 100-264 (273) alignment 
Range on Protein: 90-197
Range on HMM: 100-264/273.0
NKVTHILNVAYGVENAF------------------------------LSD----------------FTYKSISILDLPETNILSYFPECFEFIEEAKR--
..|..|  .   ||.                                 .|                .|.. .  .. |. .. ... ...||||....  
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

----KDGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAFSLVKNARPSICPNSGFMEQL
    ..|.|.|||.|||.|...... .|.        . .. .|. |... || . ..  ....|
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 107-191 5.7e-13 44.4 In-house 159-272 (288) alignment 
Range on Protein: 107-191
Range on HMM: 159-272/288.0
LSDFTY--------------------KSISILDLPETNILSYFPECFEFIEEAKRK----DGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAF
|.|.|.                    . .  .. |. .. ... ....|.......    .|.|.|||.|||.|...... .|.     . .  .. .|.
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

SLVKNARPSICPNS
  ... || .... 
krlreqRpgmvqtp
subfamily_MSG5_pd Subfamily MSG5 124-200 5.9e-12 39.0 In-house 80-156 (165) alignment 
Range on Protein: 124-200
Range on HMM: 80-156/165.0
NILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
.|   ...  . |  |. |   .||||. |.||.|.... ..|.  . |.  |. ..|.    | |. |.. ||  .
kivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmew
0050432 (Phosphotyrosine protein) phosphatases II 113-190 6.2e-11 37.6 In-house 184-284 (308) alignment 
Range on Protein: 113-190
Range on HMM: 184-284/308.0
KS----------------ISILDLPETNILSYFPECFEFIEEAKRK--DGVVLVHCNAGVSRAAAIVIGFLM-----NSEQTSFTSAFSLVKNARPSICP
                  .  .. |. .. ... ....|.|.....  .|...|||.|||.|......  |.          .. .|.  ..  ||   .
rtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq

N
.
t
0046845 (Phosphotyrosine protein) phosphatases II 115-190 4.2e-10 35.0 In-house 170-259 (284) alignment 
Range on Protein: 115-190
Range on HMM: 170-259/284.0
ISILDLPETNILSYFPECFEFIEEAKRK------DGVVLVHCNAGVSRAAAIVIGFLMNSE--------QTSFTSAFSLVKNARPSICPN
. ... |. .. ...   .||......       .|...||| |||.|......  |. .           .. .|.. ... ||    .
fhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
subfamily_RNGTT_pd Subfamily RNGTT 132-205 4e-08 27.2 In-house 104-176 (189) alignment 
Range on Protein: 132-205
Range on HMM: 104-176/189.0
CFEFIEeaKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQL-RTYQEGKE
. ||..  |. . |. |||  |  |.  ... .|.. |. |  .| .| ..|||    .  ....| | |.. .|
veeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadvee
PTPc_DSPc_SM00012 109-184 4.8e-08 28.5 In-house 4-83 (105) alignment 
Range on Protein: 109-184
Range on HMM: 4-83/105.0
DFTYKSISILDLPE--TNILSYFPECFEFIEEAKRkDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFT---SAFSLVKNAR
.. |....   .||  ..||... .. .. .....  . |.||| |||.|.. .|   .. .  .. |   . | .||  |
hyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr
subfamily_Laforin_pd Subfamily Laforin 117-177 5.2e-08 26.0 In-house 84-144 (183) alignment 
Range on Protein: 117-177
Range on HMM: 84-144/183.0
ILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAF
. ||   . .  .|..  ..     |  .| ||||||| |..||| |||.   . |..   
tedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvq
subfamily_DSP11_pd Subfamily DSP11 122-201 1.1e-07 26.0 In-house 94-174 (178) alignment 
Range on Protein: 122-201
Range on HMM: 94-174/178.0
ETNILSYFP-ECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQ
. .... |  .  ||.|. | .| .. |||  || |.  ..  .|.. |. .   | .  ..||        ....|.. .
keelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkle
subfamily_DSP23_pd Subfamily DSP23 110-186 7.2e-07 24.0 In-house 52-127 (148) alignment 
Range on Protein: 110-186
Range on HMM: 52-127/148.0
FTYKSISILDLPEtNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPS
 |.. . | |      |    |  . .|||. |.  | |||  |  |. ...  .|.  .. . . | . |.. || 
ltlvrlriddyhp.paleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
0048567 (Phosphotyrosine protein) phosphatases II 125-193 1.8e-06 22.4 In-house 56-127 (157) alignment 
Range on Protein: 125-193
Range on HMM: 56-127/157.0
ILSYFPECFEFIEEAKRKDGVVLVHCNAGV---SRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGF
. ...    .|..  . ..... ||| ||    .|.| ..  .|.   . .   |. ... .||.. |    
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrda
subfamily_CDC14_pd Subfamily CDC14 134-190 3.8e-06 21.0 In-house 254-312 (328) alignment 
Range on Protein: 134-190
Range on HMM: 254-312/328.0
EFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPS--ICPN
.|.| |.. .| . ||| ||. |. ...  .||.  . . . | . .. .||   | | 
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpq
subfamily_PTPDC1_pd Subfamily PTPDC1 142-200 3.9e-06 21.4 In-house 113-171 (182) alignment 
Range on Protein: 142-200
Range on HMM: 113-171/182.0
KDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTY
..| | ||| ||  |.  ..  .|. ... .   | .||.. ||.     . .| .. .
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkef
Y_phosphatase Protein-tyrosine phosphatase 131-184 5.9e-06 21.2 Pfam-A 157-213 (235) alignment 
Range on Protein: 131-184
Range on HMM: 157-213/235.0
ECFEFIEEAK-RKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTS--FTSAFSLVKNAR
.. . .|. |  |.| |.||| |||.|.. .|   .. .. ..   .. ...||. |
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelR
Y_phosphatase Protein-tyrosine phosphatase 131-184 5.9e-06 21.2 In-house 157-213 (235) alignment 
Range on Protein: 131-184
Range on HMM: 157-213/235.0
ECFEFIEEAK-RKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTS--FTSAFSLVKNAR
.. . .|. |  |.| |.||| |||.|.. .|   .. .. ..   .. ...||. |
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelR