Gene MTMR11 in Homo sapiens

Synonym: CRA, RP11-212K13.1, MTMR11

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP050_AA protein Get Run
HsapP050_AA_194-646 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR10_pd Subfamily MTMR10 198-642 7.3e-120 392.2 In-house 10-377 (380) alignment 
Range on Protein: 198-642
Range on HMM: 10-377/380.0
TAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGH
 .|..|...||.......|...||.|..|..||.||.|||.. ||.|.|.. |....|.|...|.|..|..|||......|....||............|
elerleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekmlelvrkch

S--DVVLVDTMDELPSLADVQLAHLRLRALCLPDSSV----AEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQL
.  ||.|||..|||||..||| |.|.||.||..|.|     ..|||||.|| ||||.|||.||..|||.. .|... |||||||...|||.....||.||
pandvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaql

LSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEE--APVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQ-SGQ
...|. ||. |||||.|.||||||||||.||| .  ||.  .||||||||||.|||.|||..|||.| ||.||.||.... .|||| |....| |.  ..
mldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvss

LNSYTQVYTPGYSQPPAGNSFNLQLSVWD--WDLRYSNAQILQFQNpgydpehcpdswlprpqpsfmvpgppssvwlfsrgaltplnqlcpwrdspslla
   . ... .....   .. .  |    .   ..|  .|.    .                                                       
splliakselkendllkdeldyrqglyaeiiksirrlaaaksylrs......................................................

vssrwlprpaissesladqewglpshwgacplppGLLLPGYLGPQIRLWRRCYLRG
                                   .. |    |.|.|| .|||| 
..................................eiirPllqipdiqlWdeCYlRW
0040695 (Phosphotyrosine protein) phosphatases II 198-641 4.9e-80 263.0 In-house 9-384 (388) alignment 
Range on Protein: 198-641
Range on HMM: 9-384/388.0
TAEDWETERKKQAA--RGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRCGGFYT--ASDPNKEDIRAVELM
.  |.. | |.. .  . ||.|.|||......|.|....||. | |....|.. ....|| | ||..|| .|. |||.. ...  . . ..|| . .| .
slydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleai

LQA--GHSDVVLVDTMD----------------------------ELPSLADVQLAHLRLRALClpDSSVAEDKWLSALEGTRWLDYVRACLRKASDISV
|..  ..| ...||...                            ..|..  |. .. .|. .|  .... ....||.|| ..|||... .|. |  |  
lkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac..lnvpdslnllslleesgwldliklilelavlivk

LVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG----GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFF
|...   ||....  ..|. ..||||.|||  |  ||| |||.|...||...||.|..|||     .. .|..||||||||||||||.|||  |||.|..
lldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerl

LLALHDSVRVPDTLTFLRNTPWERGKQSGqlnsytqvytpgysqppagnsFNLQLSVWDWDLRYSNAqilqFQNPGYDPEHcpdswlprpqpsfmvpgpp
|| |.|..  .   ||| |...|| . |                      ..  ||.|.. |....     | || |||..                   
LlfLadhlyscrfgtFlfnsekerlelsv.....................sertlslwsyllsrkse....flnplYdpss...................

ssvwlfsrgaltplnqlcpwrdspsllavssrwlprpaissesladqewglpshwgacplpPGLLLPGYLGPQIRLWRRCYLR
                                                               .||| .  ....||  .|||
.............................................................levllpslsvldlllWleyylr
Myotub-related Myotubularin-like phosphatase domain 310-484 2.3e-47 154.4 Pfam-A 173-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 310-484 2.3e-47 154.4 In-house 173-352 (353) alignment
subfamily_MTMR9_pd Subfamily MTMR9 308-485 5.1e-42 136.3 In-house 158-339 (393) alignment 
Range on Protein: 308-485
Range on HMM: 158-339/393.0
ELPSLADVQLAHLRLRALCLpDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLV
.| | | .| .  .|   |  | ..  ||.|| || . ||. |.. |. |  .. ....   .|....    |    ..||.||.  |.|||. ||..|.
slesvasiqdslaklleacs.daglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfeali

QREWVAAGHPFLTRLGGTGASE-----EAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQ
.|||. ||||| .|   ..|.|     ..||||||||||.|.|.|||| |||.| .| .|.    .    ||| ..  || ..
ereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkel
subfamily_MTMR1_pd Subfamily MTMR1 317-486 5.2e-40 129.9 In-house 163-334 (389) alignment 
Range on Protein: 317-486
Range on HMM: 163-334/389.0
LAHLRLRALCLPdsSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGH
 .. .|..|.||  .| ..|||||||.|.||..... |. |  |   |..   ||..      |    | || .||  .  ||. ||. |...||.. ||
eslkklkelvlp..nvddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGH

PFLTRLGGTG----ASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQS
.| .||| ..     .|..|||| |.|||||| .|||  ||| | ||. | | ..     ||| |.  || |..
kfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkek
subfamily_MTMR5_pd Subfamily MTMR5 297-488 1.2e-34 112.0 In-house 227-419 (483) alignment 
Range on Protein: 297-488
Range on HMM: 227-419/483.0
HSDVVLVDTMDElpslADVQLAHLRLRALCLPDSSVAEDKW---LSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLS
. ... |.....     .|. .  .|.  |||. .|.| .    |...|   ||  ... |. .. .. |.  .  ||..     .|.   .|||.|||.
kaefipvelvei....rqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqlll

APEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEE---APVFLLFLDCVWQLLQQFPADFEFSEFFLL--ALHDSVRvpDTLTFLRNTPWERGkQSGQ
 |  ||| ||. ||..||.| || |  |   | ....   ||||| |||||.|. .||| .|||..|.|   | |   .     ||| ..  ||  .|| 
dpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsn..rfrtfllDseyerl.esgl
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 322-485 2.6e-34 111.1 In-house 177-342 (404) alignment 
Range on Protein: 322-485
Range on HMM: 177-342/404.0
LRALClpDSSVAE-DKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLT
|. ..  .|.. . ..||| || .|||| ..  |. . .|. |. ..  ||...     |    ||||.|||  |  ||. ||..|...||.  || | .
lkkav..nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaq

RLGG---TGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQ
| |    .  .|..|.|| |.|||.||..|||  |||.| ||. . |..      ||| ..  || ..
RigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqn
subfamily_MTMR3_pd Subfamily MTMR3 310-486 1.2e-31 103.0 In-house 213-391 (442) alignment 
Range on Protein: 310-486
Range on HMM: 213-391/442.0
PSLADVQLAHLRLRALCLpdSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQR
. .  |. .   ||||.   .|  | .|||||| |.||  .   |..|  ..  |    |.|..      |    . .| .||  |  ||| ||. ||.|
anihavrksfnslralls..qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlver

EWVAAGHPFLTRLGGTG----ASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQS
||.. || |  | |       | | .|||| .||.| || .|||. |||.| ||. |          ||| |.  || ...
eWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeek
subfamily_MTMR6_pd Subfamily MTMR6 331-484 1.2e-30 99.1 In-house 186-341 (397) alignment 
Range on Protein: 331-484
Range on HMM: 186-341/397.0
SVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGT--GAS
| .  ..||.|| . || ...| |  .  |.  |...  ||..      |      || .||  |  ||. ||. |...||.. || | .| |     . 
sksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldedsk

EEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGK
| .|.|. ||.||||||.|||  |||.| |||.||| |   .  ||| |.  .| .
evsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrd
3-PAP Myotubularin-associated protein 552-682 3.6e-30 95.1 Pfam-A 5-141 (142) alignment 
Range on Protein: 552-682
Range on HMM: 5-141/142.0
FMVPGP-------PSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPshwgacPLPPGLLLPGYLGPQIRLWRRCYLRGRP
....|.       ... .....|  .. ..|.......|||...| ..|.|| .||.|.......|      . ...|||| .||....|| .||||..|
lryygsfarslpwkhrrsvavagesseapdllllkllisllsdcsvsspspataseqlsktassvP......adlhqlLlpqqlgldlslWsqcylRwiP

EVQMGLSAPT-----ISGLQDELSHLQELLRKWTPRISPEDHS
|...  ....      | |..|...||.||. .... .||...
eaeikgggqvqvdlklselleeiaklqrlleqrdmsdlpeanl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 334-483 1.3e-24 78.7 In-house 200-350 (405) alignment 
Range on Protein: 334-483
Range on HMM: 200-350/405.0
EDKWLSALEGTRWLDYVRACLRKASdISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEE--A
. ..   .| | |. .... |  |. .|  .  .  |....     |    ..|| |.|  |  ||. ||| |...||.. || |  |||     ||  .
dmrfwgyieetgwishiksileaat.fsaelilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneeers

PVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERG
|.|  ||||..|||.|||  |||.  .|| . | .      ||| |   .| 
pifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrv
Myotub-related Myotubularin-like phosphatase domain 198-310 3.3e-15 48.7 Pfam-A 22-145 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 198-310 3.3e-15 48.7 In-house 22-145 (353) alignment
subfamily_MTMR9_pd Subfamily MTMR9 203-297 1.2e-13 42.9 In-house 23-120 (393) alignment 
Range on Protein: 203-297
Range on HMM: 23-120/393.0
ETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHH-PGGSDLLRCGGFYTASDP--NKEDIRAVELMLQAGH
| .. . |. .||.|.||. | | .| |  . ||. | | |..    . ..|| | ||. |   .. |||..   ..|.    ||| . ..|.|....
efaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkklk
subfamily_pats1_pd Subfamily pats1 333-419 1.1e-12 39.1 In-house 366-454 (691) alignment 
Range on Protein: 333-419
Range on HMM: 366-454/691.0
AEDKWLSaLEGTRWLDYVRACLRKASDISVLVTsRVRSVILQERGDRDLNGL----LSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFL
..|.| . .|   |.| |.  |  | ..| |.  . .||.|..  |  |  |    .||| |.|| |  ||| ||. |...||.  |.|| 
sddewke.ieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfs
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 206-272 6e-12 37.4 In-house 27-95 (404) alignment 
Range on Protein: 206-272
Range on HMM: 27-95/404.0
RKKQAAR-GWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRC
|..  .   ||.|..|  .... . |... ||..| |.|. ... . ..|| | |||.|.  .| . |.
RlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRs
subfamily_MTMR5_pd Subfamily MTMR5 211-276 7.1e-12 36.9 In-house 28-94 (483) alignment 
Range on Protein: 211-276
Range on HMM: 28-94/483.0
ARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRCGGFY
   .|.|.||... |. | |  . ||... |....|   .|.|.| |   |.|.  .. |.| ||| 
rgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfe
subfamily_pats1_pd Subfamily pats1 431-478 4.2e-10 30.6 In-house 553-600 (691) alignment 
Range on Protein: 431-478
Range on HMM: 553-600/691.0
APVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNT
.|.|. ||| |||| ..||  ||| |..|| | . .      .|| . 
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyse
subfamily_MTMR1_pd Subfamily MTMR1 204-296 5.3e-09 27.8 In-house 16-112 (389) alignment 
Range on Protein: 204-296
Range on HMM: 16-112/389.0
TERKKQAAR-GWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPG-GSDLLRCGGFYTA--SDPNKEDIRAVELMLQAG
.||.       ||....|...... . |. . ||. . |......     .|| | ||| ..  .. .||.    .   .  .||| . .. .|.| 
lerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqailean
subfamily_MTMR3_pd Subfamily MTMR3 209-273 7.7e-08 24.5 In-house 39-104 (442) alignment 
Range on Protein: 209-273
Range on HMM: 39-104/442.0
QAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPG-GSDLLRCG
.    ||.|.||. |.. .| |. . ||. | |......  .   .| | . | | . |. | ||.
dlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 208-307 1.9e-06 18.9 In-house 36-139 (405) alignment 
Range on Protein: 208-307
Range on HMM: 36-139/405.0
KQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGG-SDLLRCGGFYT----ASDPnKEDIRAVELMLQAGHSDVVL
....  |.|...|  . ...| .  . | .. || .. . |    .|| | |||. |   . . ||         |  | .... . .| | |    . |
nssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcp.edelycsslalsapsktlyl

VDTMD
.|.  
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