Gene PTPRH in Homo sapiens

Synonym: R-PTP-H, SAP1, PTPRH

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP091_AA protein Get Run
HsapP091_AA_824-1103 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 820-1107 1.4e-129 426.3 In-house 5-290 (293) alignment 
Range on Protein: 820-1107
Range on HMM: 5-290/293.0
GDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLP
 .| .|.|..||.|...||...|..||..|..||..|....|....|.|||||.|.||||.||| |.....|.|||||||...||..||.||||||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

QTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQveEQKTLSVRQFHYQAWPDHGVPSSPDTLL
.|| ||||.|||..|...||||...| |.||||.||| |..|...|...|||| ||..|.|..|||.. .  |... .|||.|...|||||||....|||
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQ
.|.|..|.....|.. .| .||||||||||||.|||| ||.....| ..  |..| ..||.| |.||||.||.|.|||.|..|.....
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_PTPRD_pd Subfamily PTPRD 821-1105 2e-109 361.8 In-house 4-284 (564) alignment 
Range on Protein: 821-1105
Range on HMM: 4-284/564.0
DIPAEDFADHVRKNERDSNCGFADEYQQLSLVgHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQ
 || .....||.| . .|.  |  ||....   .. .  .|....| ||||| |...|| ||| |.... ..|||||||||. |  .....|||||||..
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSqPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLA
|. ||||.||||.|.| ||||.. | |.|||..||| .. ..|.|.| |||. || ... ..|.. | . .....  |||||. .||||||| |. .||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FWRMLRQWLdQtMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS
..|  |..  .  . || .|||||||||||| |..|..|.....|...  ...|...|. |. ||||| ||.|.|. || .|.  
lirkvraln.e.pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
0051299 (Phosphotyrosine protein) phosphatases II 821-1102 1.3e-103 341.7 In-house 4-286 (288) alignment 
Range on Protein: 821-1102
Range on HMM: 4-286/288.0
DIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQ
.|..|.....|.|  .....|...|...|  . .. .. .|.  ||  ||||...||||.||| |.......||||||||...| .....|||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLdSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV----EEQKTLSVRQFHYQAWPDHGVPSSPD
||.||||.||||.... ||||...| ||.||..|||| ... |.|...|||. |||....|||.| .  .     ..... |..||| .|||||||.||.
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

TLLAFWRMLRQWLDqtMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
 ||.|.|..|..|     ||| .||||||||||||.||||.||.||. || . ....|...|| || ||||. ||.|.....| .|
llldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 808-1103 2.5e-102 337.6 In-house 12-300 (308) alignment 
Range on Protein: 808-1103
Range on HMM: 12-300/308.0
KPELRDLVFSSPGDIPAEDFADHVRKneRDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLkpiheEPGSDYINASFMPGL--
 .  .. .. |  ... .|.. .. |   ... ..  |...|  |  . .  ||.  ||  ||||...||||.||| |     ..||||||||...|   
llfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyss

WSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLD--SQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHY
..|..|||||||||.||.||||.||||.... ||||...| ||.||..||||.  ... ..|...|||. |||....|||.| |  ....... |..|||
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

QAWPDHGVPSSPDTLLAFWRMLRQWLdqtmEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
 .|||||||.||. ||.|....|..|    .||| .||||||||||||.||||.||.||. || . .|. |.|.|| || ||||. ||.||....| .|.
tnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 822-1104 7.3e-100 329.1 In-house 2-282 (318) alignment 
Range on Protein: 822-1104
Range on HMM: 2-282/318.0
IPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT
|..||...|||. ... .  .  ||..|| . .. ... .  . |.||||| |.|.|| .|| |.....|.|||||||....|  . ...||.|.|||.|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPlDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAF
. ||||.||||.| ..||||...|.|..|...||| .... ..|.|.|.|  |  ......||. . . ||...  |||.|| .|||.|||.|. .||..
ieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

WRMLRQWlDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
 |  ... .|. . || .|||||||||||. ||.|.||.... |.|.  | .|...|| |.|||||| ||.|... .| .|. 
vrqvska.qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0040438 (Phosphotyrosine protein) phosphatases II 825-1123 3.3e-98 324.1 In-house 3-297 (317) alignment 
Range on Protein: 825-1123
Range on HMM: 3-297/317.0
EDFADHVRKNERDSNCGFADEYQQLSLVGHSqSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGD
.|. ... .  . .. .. .|...|  . .. .  ||.  ||  ||||...||||.||| |.|. . ..|||||||...| . ...|||||||||.||.|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLdSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRM
|||.||||.....||||...| ||.||..||||  .. |.|...|||..||.....|.|.| .   ...... |..||| .|||||||.|||.||.| ..
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

LRQWLDqtMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLI
.|..|.   .||| .||||||||||||.||....|.||. || . ... |...|| || .|||..||.||....| .|.   . .  .| ... ...||
vreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli
0046845 (Phosphotyrosine protein) phosphatases II 841-1103 3.4e-98 323.8 In-house 1-275 (284) alignment 
Range on Protein: 841-1103
Range on HMM: 1-275/284.0
GFADEYQQLSLVGHSQ--SQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEE-PGSDYINASFMPGL-----WSPQEFIATQGPLPQTVGDFWRLVWEQ
|. .|...|  . ...  |  || . ||  ||||...||||.||| ||..... ..|||||||...|      .....|||||||||.||.||||.||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

QSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVE-EQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQ
.....||||...| ||.||..||||.... |.|...|||. |||....|||.| |  .. ..... |..||| .|||||||.||. ||.|.|..|..|..
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEG---LLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
.  ||| .||||||||||||.||||.||.||. ||    . ... |...|| || ||||..||.|.....| .|.
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0036941 (Phosphotyrosine protein) phosphatases II 832-1102 4.9e-97 320.1 In-house 5-277 (297) alignment 
Range on Protein: 832-1102
Range on HMM: 5-277/297.0
RKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLkpihEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWE
.... ... ..  |...|  . .. |  ||.  ||  ||||...||||..|| |    ...||||||||...| . ...|||||||||.||.||||.|||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

QQSHTLVMLTNCMEAGRVKCEHYWPLD-SQPCTHGHLRVTLVGEEV--MENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQW
|.....||||...| ||.||..||||.  .. |.|...|||...||   ...|.|.| .. ....... |..|||  |||||||.||..||.|....|..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

LDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQ---SEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
|.....||| .|||||||||.||.||.|..|.||.    || . ....|.|.|| || .|||. ||.||....| .|
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 833-1102 5.3e-97 319.8 In-house 5-272 (273) alignment 
Range on Protein: 833-1102
Range on HMM: 5-272/273.0
KNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLkpihEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQ
 ...... ... |...|  . .. .  ||.  ||  ||||...||||.||| |    ...||||||||...| .....|||||||||.||.||||.||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

QSHTLVMLTNCMEAGRVKCEHYWPLDSQ--PCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLD
.....||||...| ||.||..||||. .  . |.|...|||..||. ...|||.| |  .. .... |..|||  |||||||.|.. || |....|..| 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
.....|| .||||||||||||.||||.||.||. || . ... |...|. || ||||. ||.||....| .|
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 829-1107 3.9e-96 316.5 In-house 10-284 (288) alignment 
Range on Protein: 829-1107
Range on HMM: 10-284/288.0
DHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRL
..| | ..... || .||..|. .....|. ... ..|. ||||||.||||  || ||  .||.|.||||||.. |  . ...|||||||..||.|||.|
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLqvEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQw
|.|....|.||||. .| |. |||.||| . .|  .|.. ||||... .|....|.|||    ... | . |..|.|||||||| |   ||.. |.. . 
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv.

lDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQ
  .. . || ||||||||||||| |||| |. ....|  .  ...| |.|..|.|.|||. ||.|.....|   .. ..
.anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv
0045450 (Phosphotyrosine protein) phosphatases II 821-1102 8.4e-96 316.6 In-house 8-304 (307) alignment 
Range on Protein: 821-1102
Range on HMM: 8-304/307.0
DIPAEDFADHVRKNERDSNCGFADEYQQLSLVGH--SQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEE-PGSDYINASFM--------PGLWSPQ
 |.|...  .|... .|.. |.. |...|  | .  . .  .|.  ||  ||||...||||..|| |...... ..|||||||..        .| ....
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

EFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV-EEQKTLSVRQFHYQAWPD
.|||||||||.|| ||||..|||.....||||...| ||.|| .|||..... |.|...|||..||.....||| | .    ...... |..||| .|||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

HGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGL---LGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
||||.|...||.|....|..|... .||| .||||||||||||.||....||||..||    . ... |...|| || .||.. ||.||....| .|
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 822-1101 3.8e-94 310.5 In-house 2-276 (278) alignment 
Range on Protein: 822-1101
Range on HMM: 2-276/278.0
IPAEDFADHVRKNERDSNCGFADEYQQLSLVGHsQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT
|. .|.......  .... ..  |...|  . .  .. .|   ||  ||||...||||.||| |... ....|||||||...| . |..|||||||||.|
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPldSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAF
|.||||.|||....|.||||...| ||||| .|||  ... |.|...|||..||.....||| | .    . ... |...|| .|||||||.|...|| |
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

WRMLRQWLDqtMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF
 ...|..|.   ..|| .||||||||||||.|||..||.||..|| . ... |...|| || .|||. ||.||....| .
lkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 821-1104 6.4e-93 306.7 In-house 13-291 (297) alignment 
Range on Protein: 821-1104
Range on HMM: 13-291/297.0
DIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSqsQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEE-PGSDYINASFMPGLWS-PQEFIATQGPL
.|| . .. ..... ..|. ..  |...|  . ..  . .|   ||  ||||...|||| ||| |||. .  ..|||||||...| .  ...||||||||
piplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

PQTVGDFWRLVWEQQSHTLVMLTNCMEAGRvKCEHYWPLDSQpcTHGHLRVTLVGEEVMENWTVRELLLLQveEQKTLSVRQFHYQAWPDHGVPSSPDTL
|.||.||||.||||.....||||...| || ||..||| ...  |.|...|||...|. ...|||.| .    ..... |..|.|  |||||||.|...|
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslell

LAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
| | ...|..| .. .||| .||||||||||||.||.. .|.||..|| . ... |...|| || .|||. ||.||....| .|..
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040439 (Phosphotyrosine protein) phosphatases II 860-1102 6.1e-88 289.8 In-house 5-246 (249) alignment 
Range on Protein: 860-1102
Range on HMM: 5-246/249.0
VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLdS
||.  ||  ||||...||||.||| |... . ..|||||||...| .....|||||||||.||.||||..||......||||...| ||.||..|||| .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

QPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL
.. ..|...|||. .||....|||.| |  ....... |....|  |||||||.|...||.|....|..|... .||| .||||||||||||.||.. .|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
.||. |. . ... |...|. || .||.. ||.||....|..|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
DSPc_SM00195 843-1102 1.6e-86 285.3 In-house 3-262 (263) alignment 
Range on Protein: 843-1102
Range on HMM: 3-262/263.0
ADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTN
  |...|    ....   |  ..|..||||.|.|||| .|| ||......|||||||... | ......||||||||.|| ||||.|||..... ||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

CMEAGRVKCEHYWPLDS-QPCTHGHLRVTLVGEEVME-NWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTmeGGPPIV
..| |. ||..||| .| .. |.|...|.|| .| .. ....|.| | . ....| .|.|..|..|||||||.|.. .|.. |..... ...   || .|
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
|||||||||||....|..|..|..|  .  |. |...|..|| ||||..|| |....||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 843-1102 1.6e-86 285.3 In-house 3-262 (263) alignment 
Range on Protein: 843-1102
Range on HMM: 3-262/263.0
ADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTN
  |...|    ....   |  ..|..||||.|.|||| .|| ||......|||||||... | ......||||||||.|| ||||.|||..... ||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

CMEAGRVKCEHYWPLDS-QPCTHGHLRVTLVGEEVME-NWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTmeGGPPIV
..| |. ||..||| .| .. |.|...|.|| .| .. ....|.| | . ....| .|.|..|..|||||||.|.. .|.. |..... ...   || .|
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
|||||||||||....|..|..|..|  .  |. |...|..|| ||||..|| |....||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 829-1105 2.7e-86 284.2 In-house 4-279 (281) alignment 
Range on Protein: 829-1105
Range on HMM: 4-279/281.0
DHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRL
 |........| ||. ||..|. .| ...   . | ||  ||||.|.  || .|| ..| .|.  .|||||.|.||. ...|.||||||.|... .||..
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLlQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQW
||||. ...||.|. .|||..|| .||| |..  . |...|. . ||  ...  |.. | . |. .| .|.|..|.||||||||...  || | . ... 
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

LDQTMEgGPPIVHCSAGVGRTGTLIALDVLLRQLQSE-GLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS
 ..  .  | ..||||||||||| |||| |......|   | .   |...|..| ||||| .|| |... .|. |.. 
tekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPRG_pd Subfamily PTPRG 822-1107 4.6e-86 284.2 In-house 1-292 (563) alignment 
Range on Protein: 822-1107
Range on HMM: 1-292/563.0
IPAEDFADHVRKNERDSNCGFADEYQ--QLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGS-DYINASFMPGLWSPQEFIATQGPL
.| ..|| || .   |.. ||. |..  |   . ..     ... ||  |||| |...|| ||| |.|. .. .. |||||... |    ..||||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLdSQPCTHGHLRVTLVGEEVMENWTVRELLLLQ--VEEQK----TLSVRQFHYQAWPDHGVP
..|. ||||..|||.....||.||  | || ||. |||   .. | |.|.|||. |||.   |||.| . .  ....|     . |||.||  |||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

SSPDTLLAFWRmlRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQ
...   | | .  ..   .  | || .||||||||||||.|.|| ||.|.|.|     | |....|  |. .|||| ||.|||. .|  ..   .
ehslpvLifvk..kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 821-1104 2.2e-85 281.5 In-house 4-285 (319) alignment 
Range on Protein: 821-1104
Range on HMM: 4-285/319.0
DIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSqSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQ
.|. ......... .  .. ... |...|.  .   .   ||  ||. ||||.|.|.|| .|| |..... .|||||||||. |    ..|||||.|| .
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPlDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK-TLSVRQFHYQAWPDHGVPSSPDTLL
|. ||||.|||..|...||||.  | ..||...||| . .. . |.| |||  || .|.. .|.| | .  ..  | .| .|.|..||||.|| .  .||
tiedfWrmvWeeessivvmltklveklkvklkkywp.eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

AFWRMLRQWLDQTmEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
.... .|.  ..| . || .|||||||||||| |.||. | ... ||.|  ||.|...|  |..|||...|| |... .| ... 
dllkrirksrekt.qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0042113 (Phosphotyrosine protein) phosphatases II 863-1102 3.6e-85 280.5 In-house 6-243 (245) alignment 
Range on Protein: 863-1102
Range on HMM: 6-243/245.0
ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLdSQPC
  ||  ||||...||||..|| |.|. ....|||||||...| . .. |||||||||.||.||||..||....|.||||...| |||||..|||| ... 
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

THGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQtMEGGPPIVHCSAGVGRTGTLIALDVLLRQL
|.|...|||..||.....|||.| .  . . ... |...||  |||||||.....|| | ...|..| .  ..|| .||||||||||||.||.. .|.||
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleql

QSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
..|. . ... |...|. || .|||. ||.||....| .|
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 839-1103 4.5e-85 280.7 In-house 6-273 (278) alignment 
Range on Protein: 839-1103
Range on HMM: 6-273/278.0
NCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPlkpiheepgsDYINASFMPGLwsPQEFIATQGPLPQTVGDFWRLVWEQQSHTLV
.. .  |...| | |. ..  .|   .| .||||...||||.|||           ||||||...|   |..|||||||||.|| ||||..||......|
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitviv

MLTNCMEAGRVKCEHYWPlDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQV----EEQKTLSVRQFHYQAWPDHGVPSSP--DTLLAFWRMLRQWLDQ-
|||...| ||.||..||| .... |.|...|||. |||....|.| ||.  .    |. ... |...||  ||||||||.|  . .| .....|..|.. 
mltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

----------TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLqsEGLLGPFSFVRKMRESRPL-MVQTEAQYVFLHQCILRFLQ
            .||| .|||||||||||||.|.. .|..|  || . ... |...|. ||  .||.. ||.||....|..|.
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRA_pd Subfamily PTPRA 822-1102 1.5e-84 278.7 In-house 14-295 (330) alignment 
Range on Protein: 822-1102
Range on HMM: 14-295/330.0
IPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT
.| |.. . .|.   | |  | .|.. |       .  .||  ||. |||. |.||||.||| | ... .. ||||||||. |    ..|||.|||. .|
lpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeet

VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSqPCTHGHLRVTLVGEEVMENWTVRELLLLQV----EEQKTLSVRQFHYQAWPDHGVPSSPDT
| ||||..|||.|.|.||||.  |  . ||. ||| .    |.|..||..  |.|....|||..|. |.    .|.|.  |||||...||| |||. |  
vedfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG

LLAFWRMLRQWldQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
.| . . ...   .  ..|| .||||||||||||.|.|| .| ....|...  | ||...|  || ||||. ||.|... .| . 
mlkllkkvkkl..nqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN6_pd Subfamily PTPN6 832-1108 2.4e-83 274.6 In-house 18-303 (306) alignment 
Range on Protein: 832-1108
Range on HMM: 18-303/306.0
RKNERDSNCGFADEYQQLSLV--GHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKpIHEEPGSDYINASFMPGLWS--PQEFIATQGPLPQTVGDFWR
...|. .. || .|...|.     .  |.. ..  ||. ||||.|.||.| .|| ||  .. ||||||||... . .    ...||||| |..|| ||||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

LVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQ-VEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLR
.||...|. .||.|. .| |. || .|||  ..  ..|...|| | |. ......|||.. .  ..... .|.|.|...|||||||..|...|.|.. ..
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

QWLDQTM--EGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPF---SFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQA
.  ....  | || .||||||.|||||.| .|.||......||  ..   ..|...|| |  .||||.|| |... |  ..... ..
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 829-1104 5.3e-83 273.7 In-house 16-292 (298) alignment 
Range on Protein: 829-1104
Range on HMM: 16-292/298.0
DHVRKNERDSNCGFADEYQQLSLVGH---SQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDF
  . .... .  |.|.|.|.|. | .   .... ||...||. |||| .....| ||| |. ....  ||||||||. .    . |||||.||..|| ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPlDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRML
||.|.|... |.|||||  | ...|...||| |..  |.|...|.|  .|.. . .||.| . . .|.|. .|||.|.  |||.|||.   ..|.. |  
WrmvteedigtiVmltnleeldktkyhkywP.degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

RQwLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
|.   |     | ||.|||||||.|| ||.| .| ... |  .  |  |. .|..|| .||||.||||... .|..|. 
ra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_PTPN12_pd Subfamily PTPN12 856-1108 1.9e-81 268.2 In-house 30-283 (290) alignment 
Range on Protein: 856-1108
Range on HMM: 30-283/290.0
QSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW
 |. .....|| .||||...|||| ||| |. |.||.|||||||.|. |  ...|.||.|||||.|. ||||..||.. . .||. . .| |. |||.||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PLD-SQPCTHGHLRVTLVGEEVME-NWTVRELLLLQVEEQKtlSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDqtMEGGPPIVHCSAGVGRTGTLI
|    .....|...|||  |. .. ....| | . . .|..  .|.||||.||||||||||...||.. ...|.  .   |  | .||||||||||||.|
peegeeelefgefevtleeekavdddflirtLkveaqkesr..kvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtii

ALDVLLRQLQSEGL---LGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQA
|.|   ..|..| .   |  |. |...|. |. .|||. ||........ ..|.. ..
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
Y_phosphatase Protein-tyrosine phosphatase 866-1099 5.3e-81 266.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 866-1099
Range on HMM: 1-234/235.0
NNAKNRYRNVLPYDWSRVPLkpiHEEPG-SDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWP-LDSQPCT
|  ||||...|||| .|| |   ....| ||||||... | .....||||||||..|..||||.||.......||||...| ||.||..|||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGHLRVTLV-GEE-VMENWTVRELLLLQVEEQK-TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLdqTMEGGPPIVHCSAGVGRTGTLIALDVLLR
.|...|.|.  |.  ....|.|.| | . .|.. . .|.|.||..|||||||.||. || . |.....   . . || .||||||||||||..|||.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

QLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL
||..|. .  ...|...|..|| |||...||.||...||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 866-1099 5.3e-81 266.8 In-house 1-234 (235) alignment 
Range on Protein: 866-1099
Range on HMM: 1-234/235.0
NNAKNRYRNVLPYDWSRVPLkpiHEEPG-SDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWP-LDSQPCT
|  ||||...|||| .|| |   ....| ||||||... | .....||||||||..|..||||.||.......||||...| ||.||..|||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGHLRVTLV-GEE-VMENWTVRELLLLQVEEQK-TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLdqTMEGGPPIVHCSAGVGRTGTLIALDVLLR
.|...|.|.  |.  ....|.|.| | . .|.. . .|.|.||..|||||||.||. || . |.....   . . || .||||||||||||..|||.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

QLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL
||..|. .  ...|...|..|| |||...||.||...||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0037934 (Phosphotyrosine protein) phosphatases II 860-1100 7.4e-80 263.3 In-house 4-240 (243) alignment 
Range on Protein: 860-1100
Range on HMM: 4-240/243.0
VASASENNAKNRYRNVLPYDWSRVPLkpiheePGSDYINASFMPGLwsPQeFIATQGPLPQTVGD----FWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW
.|.  ||  ||||...|||| ||| |      .|||||||......  |. .||||||||.|| |    |||..||......||||...| ||.||..||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PlDSQpcTHGHLRVTLVGEEVMENWTVRELLLLQVE-EQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQ------TMEGGPPIVHCSAGVGR
| ...  |.|...|||..||.....|||.|||  .. .. |. |...|| .|||||||.||. ||.|....|.....        .||| .|||||||||
p.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTLIALDVLLRQLqseGlLGPFSFVRKMRESRPL-MVQTEAQYVFLHQCILR
||||||....|..|   | ..... |...|| ||  .|||. ||.||....| 
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 820-1103 1.2e-79 262.6 In-house 2-287 (307) alignment 
Range on Protein: 820-1103
Range on HMM: 2-287/307.0
GDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLP
|.|. .| .. .....||.. |.| ||..|     ..|  |.   ||. |||| .. ..|  || ||.|  .  ||||||||. |    ..||| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

QTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDsQPCTHGHLRVTLVGEEVMENWTVRELLLLQVE-----EQKTLSVRQFHYQAWPDHGVPSS
.|.|||||...||.....|||.|  |  | ||..||| . . . .|.. |.|| || ..... ||| . ...     ....  | |.||..|.|  || .
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PDTLLAFWRMLRQWLDQTmeGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
. .|| . ...|.   .    .| .|||||||||.|...|||.|| ||. |  .  | .|...|. |.|.||  .|||||.. .| . .
argllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRK_pd Subfamily PTPRK 823-1104 2e-76 251.9 In-house 5-280 (314) alignment 
Range on Protein: 823-1104
Range on HMM: 5-280/314.0
PAEDFADHVRKNERDSNCGFADEYQQLSLVghsqsQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV
 ..|  ... . .|  . || .||. |          .|   ||..|||. ..|.|| ||| |..|...| ||||||... .   |..||.|||||..||
rvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

GDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPctHGHLRVTLVGEEVMENWTVRELLLLQ--VEEQKTLSVRQFHYQAWPDHGVPSSPDTLLA
 ||||||..... ..||||. .| ||||| .||| |..   .|...|.||  |. ..  || . . .     ...  ||||.. .||||.|| |  .||.
kdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

FWRMLRQWLDQtmEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR-FLQQ
. | . .. ..  | |. .|||||| ||||| ||.|..|  .. ||..  |  |...|.... ||.|| ||.|... ||   |  
lvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcg
subfamily_PTPN9_pd Subfamily PTPN9 826-1105 1e-75 249.5 In-house 5-293 (297) alignment 
Range on Protein: 826-1105
Range on HMM: 5-293/297.0
DFADHVRKNERDsncGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDF
.. ..|.....    |   ||...     .   ...    |  |||| .|| || .|| |. ..|.. ||||||.|. |   .. ||||||||..|| ||
elvayvkekgkr...GlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPC-THGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRM
||.||||.  ..|| | ..| ||.|| .||||... .  .|.|.|. |  |..|...|| | . .|..... .|  | . .|||.|||||  .|| . ..
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

LRQWLDQT----------MEGGPPI-VHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS
 |.   ..             |||| ||||||.|||||.|.||. | .|...| .  .  |...|. |  ..||. ||.| ....| . ...
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 822-1100 2e-74 245.3 In-house 6-277 (315) alignment 
Range on Protein: 822-1100
Range on HMM: 6-277/315.0
IPAEDFADHVRKNERDSNCGFADEYQQLSlVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT
|| ...  .| ...  .. || ..|. .   |. .   ||  .||  |||| |...|| ||| |  .  .|.|||.||.|..|   .. .||.|||....
ipldqlityvaqkkastkngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDsqPCTHGHLRVTLVGEEVMENWTVRELllLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAF
|.||||||.|..  ..||||| .|  . |.|.||| .    ..|.. ||.. ||| ...||| |    | ...   | |.|| .||| ||| .  .|. .
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl

WRMLRQWLDQTMegGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR
 |  .|. ....  |. .||||||||||||.|.|| .| |.. | ..  . |....|. |  |||. .|| |... .| 
irtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 860-1104 2.3e-73 241.5 In-house 3-244 (250) alignment 
Range on Protein: 860-1104
Range on HMM: 3-244/250.0
VASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVkCEHYWPLDS
||   .|. |||| .....| ||| |.. . .  ||||||||. |    . ||||||||..|. ||||.|.|..| |.|||||  | ... ...||| . 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

qPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL
 . ..|...|.|  .|.. ..|.|.| | . ....   |||.|. .||| |||    . |.. . ...  .|  . .| ||.|||||||.|. ||.| .|
.aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqa.sqqqagnaPvivqCsaGvgrsGafiaidavl

RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
 .|. |  .  | .....|. || .|....||||... ||..|. 
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 824-1103 1.2e-72 239.6 In-house 6-284 (305) alignment 
Range on Protein: 824-1103
Range on HMM: 6-284/305.0
AEDFADHVRKNERDSNCGFADEYQQLSLVghSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVG
 .|.| ...... .|. |.  .|..|     ..|  | . ..|.||||.... ..| .|. |.. .... |||||||.. |  . ...|..||||..|| 
lddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQP-CTHGHLRVTLVGEEVMENWTVRELLLLQ-VEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAF
|||||..| . .|.||||. .| |. ||. |||   .    .|.. |.|  |. ..... |.| . .  |.... .| |..   ||||||| .. .|| .
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

WRMLRQwlDQTME-GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
 . ...  ||  . | | .|||||||||||. ||.|. | .|. |. .  |  ....|..|. |||| .||||||. .   ..
ikrvqk..dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN3_pd Subfamily PTPN3 846-1103 1.5e-71 235.6 In-house 21-276 (280) alignment 
Range on Protein: 846-1103
Range on HMM: 21-276/280.0
YQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKpihEEPGsDYINASFM----PGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT
..||     . .  .|  .|| .|||||..||||  || ||   |..  |||||...    |.    . .|||||||..|. |||..||||.|...||||
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWldQTMEGGPPIVH
. .| ||||| .|||  .. ...|...|..  |.  ... .|||.| . |...  .. |. | ||||||||.... .| | . .|.   .. .  | .||
tlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePvvvh

CSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
||||.|||| ||.|.. |  ....  . |   ||.||. |  .|||..|| |. ..||.  .
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 821-1100 4e-71 234.9 In-house 15-289 (319) alignment 
Range on Protein: 821-1100
Range on HMM: 15-289/319.0
DIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMV-ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLP
|.||.     ....  |    .  |..... .| . ...  |   .|  |||. |.|..| ..| |...  | .||||||||. |  ... .||.||||.
dfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPld

QTVGDFWRLVWEQQSHTLVMLTncmeagRVKCEHYWPLDSQP-CTHGHLRVTLVGEevMENWTVRELLLLQ-VEEQKTLSVRQFHYQAWPDHGVPSSPDT
 |. ||||..||... |.|.||      . ||  ||||. .    .....|..| |   ....||.. | .  .|.   ...|||.. |||.||| .|  
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee..taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd

LLAFWRMLRQwLDQTMEGGPP-IVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR
|. . . .|  | . ...  . .|||||||||||. |.||||| ... |  .  . ||| .|. |. .||  .|| |..  .| 
lmrlvkkvrh.ltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN13_pd Subfamily PTPN13 843-1104 1e-69 229.9 In-house 14-271 (273) alignment 
Range on Protein: 843-1104
Range on HMM: 14-271/273.0
ADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKpihEEPGsdYINASFMPGLWSPQE--FIATQGPLPQTVGDFWRLVWEQQSHTLVML
|.|...|  .   ..  |.   ||..||||||||||| .||.|.   .| |  |||||..      .|  .||.|||||.|| |||..||||... ..|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TNCMEAGRVKCEHYWPLDSQ-PC-THGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDqtmEGGPP
|.  | |.|||. |||   . .   .. |.|.|.. . .....||.| . ..| ...  | .... .|||||||||.. || | . .|.  .   . || 
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPi

IVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
.||||||.||.||||..||.|  .. .  .     |||.|| |  .|||. ||.| .. ||  |..
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 819-1102 2.4e-69 229.0 In-house 2-288 (325) alignment 
Range on Protein: 819-1102
Range on HMM: 2-288/325.0
PGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGhSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPL
|| |   .. .|| |.. . . ||| |.. |  .. .... ||   || ||||..||...| ||| |.  ...| |||||||..      . |.|.| ||
pgsiavvnlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPl

PQTVGDFWRLVWEQQsHTLVMLTNCMEAGRVKCEHYWPLD-SQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDT
..|..|.|||| . .  ..|...| .. |  .|  ||| . ..  | | |.| |.  | . ..  | | . ||.. .|.||.||..|.|.| ||.  | |
tatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpat

LLAFWRMLRQWLDQ----TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
|... ... .  ..    |   .| .|||||||||||..|.|  .| ..  |  .  | ||.|.|. || ||.|  ||.......  ..
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 853-1106 5.3e-69 227.2 In-house 8-268 (270) alignment 
Range on Protein: 853-1106
Range on HMM: 8-268/270.0
GHSQSQmVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLW-SPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKC
 .|.|. . .|  ... |||...||   .|| |....|.. . |||| ...|   .....||..|||| |. .|||..||......||.|. .| || ||
etsesd.lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

EHYWPLDSQP---CTHGHLRVTLVGEEVMENWTVRELLLLqvEEQKTLSVRQFHYQAWPDHGVPSSPD------TLLAFWRMLRQWLDQTMEGGPPIVHC
| ||| ...    ...|...|. . || .| . ...| |   |. ..  .  |.|..|||||||...|       ||.  | .|.. ... ...| .|||
erYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSA
||||||||||||||  .| |.... . . . ....|. |. .||.  || ||.. .. . .. |
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 845-1100 9.2e-69 227.1 In-house 3-253 (284) alignment 
Range on Protein: 845-1100
Range on HMM: 3-253/284.0
EYQQLSLVGHSQS-QMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTnc
|..... .| . . |  |   .|  |||. ..|..| ..| |...  | .||||||||. |  ... .|||||||. |. ||||..||... |.|.||  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

meagRVKCEHYWPLDSQP-CTHGHLRVTLVGEevMENWTVRELLLLQ-VEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwLDQTMEGGPP-IV
    . ||  ||||. .    .....|..| |   |...||.. | .  .|..  ..||||.. |||.||| .|  |... . .|  | . ...  . .|
....kdkcsqywplkivikeerfkvkvdsvee..seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrh.ltskenhranivv

HCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR
||||||||||. |.||||| ... |  .  . |||..|. |. .||  .|| |..  .| 
hcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 822-1103 4e-68 224.7 In-house 2-277 (515) alignment 
Range on Protein: 822-1103
Range on HMM: 2-277/515.0
IPAEDFADHVRKNERDSncGFADEYQQLSLvGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT
.|  .|   | || . .   |..|.. |        | ||    |  ||||.|.|||| .|| |. |...| |||.|||..|.. . . .||.|||.. .
lplaqfPafvnknrhtt..lfseefhdlpg.pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPL-DSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTlsVRQFHYQAWPDHGVPSSPDTLLA
| ||||||....  |..|.|.  |  ..|| .|||   ..    |...| ||  |   . . |.| .|. .. .|  | |||.. |||.|||    .|| 
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrt..vtqfhfteWPdkGvpkhtssllk

FWRMLRQWLDQTMegGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
. . ..   .|     | |.|||||||||| .|..|  . . .    .  | ||...|. || .|||. || |... .|  | 
likevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 822-1103 1.3e-67 222.9 In-house 3-278 (315) alignment 
Range on Protein: 822-1103
Range on HMM: 3-278/315.0
IPAEDFADHVRKNERdsNCGFADEYQQLSLVGHSqSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT
||  .|   | || .   . |..|...|     .  | ||  ..|  ||||.|.||.| .|| |. | ..| |||||||..... . . .||.||||. .
ipvaqfpafvnknrh..talfseefhdlpdPdiy.rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

VGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPL-DSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTlsVRQFHYQAWPDHGVPSSPDTLLA
| ||||.|....  |.||.|.  |  ..||  |||  ...    | ..|.|.  |   . ..|.| . . ||..|  | ||... |||.||.    .|| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrt..vtqfqftewPdkGvdkqtssllk

FWRMLRQwlDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
. . ..   |. ..  . .||||||||||| .|..|  . |.. .  .  | ||...|. || .|||| .| |... .|  |.
likevka..dngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 822-1104 1.8e-66 219.0 In-house 2-285 (290) alignment 
Range on Protein: 822-1104
Range on HMM: 2-285/290.0
IPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPG--SDYINASFMPGLWSPQEFIATQGPLP
|| ..|...| ...   | || .....|    .... .|. .|.|. .||..|...||  |..|.|| ...    .||||... |    ...||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

QTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCtHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKTLSVRQFHYQAWPDHG-VPSSPDT
.|. |||.|.|....  .||||| .| |.|||  |||  ..    |. ...|. ||.... . |.| . . .. ... || |.. ..|...| |.     
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LLAFWRMLRQWLDQTmeGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
||.. .| ..   ..   .. .||||..|||.....|... . . ..||    |. ....|  .| .|||. || ...| .|. |..
llvieemyktqrkrg..ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN23_pd Subfamily PTPN23 830-1104 4.7e-66 217.5 In-house 5-282 (288) alignment 
Range on Protein: 830-1104
Range on HMM: 5-282/288.0
HVRKNERDSNCGFADEYQQLSLV--GHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKpiheEPGSDYINASFMPGLWSP-QEFIATQGPLPQTVGDFW
.....  | . ..  ....|      ..... .| |  .  |||.|..|||| .|| |.    .   |||||||. .| .   .|||||.||..|..|||
elqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDS-QPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRML
..|.||.| ..|||..  | |. |...||| |  .. ..|.|.|||  .. .|..  |.| |   ..... ||.  ....||..|||.||.|||.|    
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldev

RQWL--DQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQ-SEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
.. .   |     | .|||||||||||..  .   .|.|.  .|||     |...|| |  |||...|. |. . .|.  ..
esayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 822-1104 7.6e-66 217.2 In-house 10-286 (297) alignment 
Range on Protein: 822-1104
Range on HMM: 10-286/297.0
IPAEDFADHVRKNERdSNCgFADEYQQLsLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSpqEFIATQGPLPQT
||  |||  |.|| . ..  | .|.. | .    |.| ||    |  |.||.|.|||| ||| |. . ..| |||.||||..|     ..|.|| | ..|
iplsdfatlvqknrh.tdv.fseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat

VGDFWRLVWEQQSHTLVMLTNCMEAGRvKCEHYWPlDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPS--SPDTLL
| |||..|...|  |.|||..  |  . || .||. |.   | |.. |.|   .  |    ||| . . . ...  |.|...  |||. |.   |  .||
vadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassll

AFWRMLRQWLDQTMEGgPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
 .   .|.  .|. || | .|||.||||||| |...|  . . . |  .  | .|.|.|..|| .|||. || |... .| .|  
klisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 844-1104 1.5e-65 216.0 In-house 9-270 (274) alignment 
Range on Protein: 844-1104
Range on HMM: 9-270/274.0
DEYQQLSLVGHSQSQMVasaSENNAKNRYRNVLPYDWSRVPLK-PIHEEPGSDYINASFMPGLWS-PQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT
.|. .| |  . . ..|   . .. ||||...|| . ||| |.    |.. |.|||| .. |     . ..|||||||.|| ||||........ .||||
keflelPlnfdqeeldv...fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt

NCMEAGRVKCEHYWPLDSQP---CTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTlsVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLD-QTMEGGP
.  || . ||..|.| . .     ..|.. .. ..    ....||.|.|...|....  |  . | .|||| .| ...||| . .  ..  . .... .|
klkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklap

PIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
 .||||||.||||  || .. .|||. |. .  .. | ..|  |  ||||. || ..|. .  .|..
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 822-1104 2.3e-65 215.4 In-house 2-280 (287) alignment 
Range on Protein: 822-1104
Range on HMM: 2-280/287.0
IPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMV-ASASENNAKNRYRNVLPYDWSRVPLKpiheEPGSDYINASFMPGLWSPQEFIATQGPLPQ
|| | |.. |.|... .| || . .. |  |.... ..  . ||.|. |||....|..|  ||.||    .   |||||.|. |  . ..||....|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQpCTHGHLRVTLVGEEVMENWTVRELLLLQVE-EQKTLSVRQFHYQAWPDHG-VPSSPDTL
|. .||.|..... ...|||.. .|  . .| .||| ..   . |. ...|. |||......|.| . . . ......|.|... .|...| |..    |
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

LAFWRMLRQWLDQTmeGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
| . .| ..   ..   .. .||||..|||.....| .. ... . || .  |. ....|  .| .||| .|| |. . .| .|. 
lvieemyktqrkrg..ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN1_pd Subfamily PTPN1 850-1100 1.9e-64 212.2 In-house 16-269 (290) alignment 
Range on Protein: 850-1100
Range on HMM: 16-269/290.0
SLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEepgsDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRV
.   .  .. .|   ||...||||.| ||| ||. |.  .     ||||||..      ...| ||||||.||. ||..||||.|...||| ...| ...
rkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCEHYWPLDSQ----PCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAG
|| .||| . .     . . .|.|.|. ||. ...||| | | ... |.| .. .||| .||| |||.|| ..| |   .|.    . . ||...|||||
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRTGTLIALDVLLRQLQSEGLLGPF---SFVRKMRESRPLMVQTEAQYVFLHQCILR
.||.||.. .| .| ... .. |        . ..|. |  ..||  |  | .. || 
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 864-1099 6.6e-61 200.5 In-house 1-236 (237) alignment 
Range on Protein: 864-1099
Range on HMM: 1-236/237.0
SENNAKNRYRNVLPYDWSRVPLKPIHEEpgSDYINASFMPGLW-SPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPC
|||..|||| |.  || ||| ||    .  ||||||... |.  .|...||.||||  .  |||..||...   .||||  .|  ..|| .|||   || 
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

THGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLS-VRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQ
..| | |.|  .| . ..||| ||| .  ..| .  . |... .|||.|||    .|| | . . .      | || |.|||||||||| .. .| .|||
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL
 . . ..  . .|  . | || ..||. ||||.|| ||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 825-1102 8.9e-59 194.1 In-house 5-279 (439) alignment 
Range on Protein: 825-1102
Range on HMM: 5-279/439.0
EDFADHVRKNERDSNCGFADEYQQLSLVGHS--QSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV
..| .|| | ... .  | ....... .         .|. . ...||||..| ..|..|| |. |   | | |||| .. | . .. .||||||  .|.
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

GDFWRLVWEQQSHTLVMLTNCMEAGRvkcehYWPLDSQpCTHGHLRVTLVGEEVMENWTVRELLLLQVE--EQKTLSVRQFHYQAWPDHGVPSSPDTLLA
 ||||||.|... |.||||| .|. .     ||| |.. . .| . |    .  . |...| . ...     .|  .| |||| ||||. ||.    .| 
ddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FWRMLRQWLDQtMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
| | .    |.  | || .||||||||||||.||||. | ||..|  .     |. .|. |  |||. .||||.....|  .
flrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 865-1099 1.9e-58 192.4 In-house 6-237 (239) alignment 
Range on Protein: 865-1099
Range on HMM: 6-237/239.0
ENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGL-WSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPlDSQpCT
 |.||||| |.. || ||| |. . ..| |||||||..     ||. .||||| .  . |||||..|...   .||||  .|  . || .||| ||    
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dst.sk

HGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwlDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQ
.  |||||   ||. .. .| ... || . .   | |.|.  |||.|||    ..| . | . .  |      | ..||||||||||... .| .||| .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqak

SEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL
 .  .  | .|. .|| || ||||  ||||.| ..|
kqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 865-1099 2.2e-58 192.2 In-house 7-238 (239) alignment 
Range on Protein: 865-1099
Range on HMM: 7-238/239.0
ENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGL-WSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPlDSQpCT
 |.||||| |.. || ||| |. . ..| |||||||..     ||. .||||| .  . |||||..|...   .||||  .|  . || .||| ||    
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dst.sk

HGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwlDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQ
.  |||||   ||. .. .| ... || . .   | |.|.  |||.|||    ..| . | . .  |      | ..||||||||||... .| .||| .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqak

SEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL
 .  .  | .|. .|| || ||||  ||||.| ..|
kqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN14_pd Subfamily PTPN14 844-1105 2.5e-57 189.2 In-house 27-299 (300) alignment 
Range on Protein: 844-1105
Range on HMM: 27-299/300.0
DEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEpGSDYINASFMPGLWSPQ--EFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT
 ||....   .     .|.  ||. |||...||||. .|| |.| .|.  ..||||| .    . .  ..|..||||..|| |||..||||. . .||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NCMEAGRVKCEHYWPLD---SQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRML---RQWLDQTME-
.  | |. |. .|.| .    .  ..|. .||    |  .  . . | |  .  ..  .|  . |. |||||||. ... | . ...   |.  ....| 
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

---GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS
     | .||||||||||| ||  |.|.  |. .  .   . ....|| | |.||| ||| |... ....|..|
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 855-1105 7.1e-57 187.4 In-house 25-280 (287) alignment 
Range on Protein: 855-1105
Range on HMM: 25-280/287.0
SQSQMVASAS--ENNAKNRYRNVLPYDWSRVPLKpIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCE
| . .  .|    .  |||| .|||.| .|| |   . | ||||||| ....    ..|||.|||.. ||.||||.|.|..| .....|  .| .| || 
sstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

HYWPLDSQPCTHGHLRVTLVGEEVME-NWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQ---TMEGGPPIVHCSAGVGR
.|||   .|   |   |.|.  ...| ...|| | |...| ...  |.|... .|||.... .   |. |    .| ..    . | ||..||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS
.|.|.|. ||...|.. | . .   | ..|| |  .||.  |. .| . .  . .  
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_CG7180_pd Subfamily CG7180 839-1101 1.5e-55 183.0 In-house 16-289 (296) alignment 
Range on Protein: 839-1101
Range on HMM: 16-289/296.0
NCGFADEYQQLSLVGHSQSQmVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLV
.  .  |... . .   . .  .  .||  |||. .|.|||  || |. .. |  ||||||... ..  ..|.| |..|  .||..|||||........|
rveyklelkltprleigdCa.gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavv

MLTNCMEAGRvKCEHYWPLDSqPCTHGHLRVTLVGEEVMENWTVRELLLLQV----------EEQKTLSVRQFHYQAWPD-HGVPSSPDTLLAFWRMLRQ
.||. ..  . ..  ||| .|    .|.. | .| |. . | . |.. | .           .. .|  |..|... |.  . ||.|  .|. . |. |.
vLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

WLDQT---MEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF
| ...    | || .|..| |..|.|  .|.|. | ... |. .  | .|...|.||| .|..  .| .. . .| .
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0051429 (Phosphotyrosine protein) phosphatases II 892-1108 1.8e-55 183.8 In-house 2-231 (272) alignment 
Range on Protein: 892-1108
Range on HMM: 2-231/272.0
PGSDYINASFMPGLWS---PQEFIATQGPLPQTVGDFWRLvWEQQSHTLVMLTNCMEAGRVKCEHYWP-----------LDSQPCTHGHLRVTLVGEEVM
| |.||||....|...   |  .....|||| |. ||||| .|.. .| |.|....| ||.||. |||            . .. ..|.|||||. ||..
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

ENWTVRELLLLQV-EEQKTLSVRQFHYQAWPDHGVPSSPdtLLAFWRMLRQwldqtmeGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLG-------
.....|||||  .   .... |...||..|||||||...  ||.. ..|..       ||| .||||||..||||..||. ||...  |  .        
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-PFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQA
 .. .|...|. || .||||.||.||....| .|   ...
yleeaveelraqrpgavqteeqylflyeallellrsllsv
subfamily_PTPRN_pd Subfamily PTPRN 854-1099 2.6e-53 175.7 In-house 44-289 (297) alignment 
Range on Protein: 854-1099
Range on HMM: 44-289/297.0
HSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWS-PQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCE
. ... ||.| .|  |||...||||| ||| ||   ..  |||||||..         .|||||||..|| |||..|||| .  .|.||.  | |  .|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

HYWPLDSQpCTHGHLRVTLVGEEV-MENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQtmEGGPPIVHCSAGVGRTGT
.||| . .  ...   | || | .  ... || . | ... ..| .| |||. .||..|||.|. .|| | | . .         | .||||.|.||||.
rywpdeGs.evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGv

LIALDVLLRQLQS-EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL
 |..|..| .|.     .   . . ..|. || .|.|..|. |  ... 
yilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 822-1100 2.2e-52 172.8 In-house 4-234 (392) alignment 
Range on Protein: 822-1100
Range on HMM: 4-234/392.0
IPAEDFADHVRKNERdSnCGFADEYQQLSLVgHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQT
||. .|   | || . | . |..|...|    .   | ||    |  ||||.|.|||| .|| |. | . | |||.|||..|.. . . .||.||| . .
ipvaqfpafveknrh.s.alffeefhdlpgp.diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

VGDFWRLVWEQQSHTLVMLTNCMEAGrvkcehywpldsqpcthghlrvtlvgeevmenwtvrellllqvEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAF
. ||||.|....  |..|.|.  |.                                              ... .| |||.  |||..||    .|| |
lddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkf

WRMLRQWLDQTmeGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR
 . ..    |     | |.|||||||||| .|..| .. . .   ..  | || ..|. || ||||. || |.. ..| 
ikevkadfGqy..thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 842-1100 3e-52 172.3 In-house 11-264 (283) alignment 
Range on Protein: 842-1100
Range on HMM: 11-264/283.0
FADEYQQLSLvgHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEepgsDYINASFMP---GLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLV
| . ...||.   ...  .|||.||. |||.....|.|  || ||.  .    |||||.|.|        ...|..|.|| .|| |||..|....  ..|
frevlkrlsv..pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLTNCMEAGRVKCEHYWPLDSQpCTHGHLRVTLVGEEVMENWTVRELLLLQV-EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRqwLDQTMEGGP
|||. .|  |.||  ||| .     .| . |||  |   . ....|||| .    ..|| .  . .. | . |  .  ..|. | ..    | .  . ||
mltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvis..lqteskkgP

PIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR
 .||||.|.|||...||. . . ....| ..  |. |. ||| |. .|||  || ..|. .| 
ivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 835-1104 4.6e-52 171.6 In-house 13-295 (301) alignment 
Range on Protein: 835-1104
Range on HMM: 13-295/301.0
ERDSncgFADEYQQLSLvGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHE--EPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQ
. ..   |...|..|.  |...| .|   .||.| ||..|. .||  |. ||| ..      .|||||.. |  . ..|||.|||. .|. |||||.|..
hsnk...feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

QSHTLVMLTNCMEAGRVKCEHYWPL-DSQPCTHGHLRVTLVGEEVMENWTVRELLL--------------LQVEEQ-KTLSVRQFHYQAWPDHGVPSSPD
.  ..||.||  |  . |||.|||  . .  . |.. |||| | |. ....|.| .              ..|... .. .| |..   ||..||   | 
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TLLAFWRMLRqWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
| |           | ..||| .||||..|.|.|. ..... | | ..||    |  .. .| |.| .|.|  ||..... | ..|| 
tvLqviddvi.hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
0041856 (Phosphotyrosine protein) phosphatases II 866-1103 2.3e-51 169.3 In-house 1-172 (182) alignment 
Range on Protein: 866-1103
Range on HMM: 1-172/182.0
NNAKNRYRNVLPYDWSRvplkpiheepGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTncmeagrvkCEHYWPldsqpcthg
|  ||||...||||.||          ..|||||... | . ...||||||||..|| ||.|...|.. .|.|.||         .|.|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

hlrvtlvgeevmenwtvrellllqveEQKTLSVRQFHYQAWPDHGVPSsPDTLLAFWRMLRQwldqtmEGGPPIVHCSAGVGRTGTLIALDVLLRQlqse
                          |  .  . |..|  |||||||. .|.||.| .. ..      |||| .|||||||||||||.|.......    
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

GlLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
| ..... |. .|. || ||.|. ||.||....| .|.
g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
0036282 (Phosphotyrosine protein) phosphatases II 893-1096 3.2e-50 165.5 In-house 1-164 (174) alignment 
Range on Protein: 893-1096
Range on HMM: 1-164/174.0
GSDYINASFMPGLWSPQEFIATQGPLPqtvgdFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLdsqpcthghlrvtlvgeevmenwtvrellllqVEE
||||||||.. . . . ..||.||||.     ||....|....|.|||....| |..|| .|||                                   |
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

QKTLSVRQFHYQAWPDHGVPSSPDtLLAFWRMLRQWLDQtMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQsEGLLGPFSFVRKMRESRPLMVQTEAQYV
  . .. |..|  |||||||...  || | . ....| .  .||| .|||||||||||||.|.. .||.|  |.|   ...||..|  || ||||. || 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FLHQ
||..
flyy
0043147 (Phosphotyrosine protein) phosphatases II 891-1096 6.3e-47 154.8 In-house 2-155 (172) alignment 
Range on Protein: 891-1096
Range on HMM: 2-155/172.0
EPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCmeagrvkcehywpldsqpcthghlrvtlvgeevmenwtvrelllLQV
..||||||||.... . |..||||||||. |. ||||...|.. ...|.||..                                            |  
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

EEQKTLSVRQFHYQAWPDHGVPsSPDTLLAFWRMLRQWLdQTMEGGPPIVHCSAGVGRTGTLIALDVLLrqlqsEGLlGPFSFVRKMRESRPLMVQTEAQ
 |. . .. |..|  ||||||| ... || | . ....| .  .||| .|||||||||||||.|.. .|     .||  ..  |. .|| || .||.. |
pellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsq

YVFLHQ
| ||..
yrflyy
0046846 (Phosphotyrosine protein) phosphatases II 884-1103 2.8e-46 152.8 In-house 2-174 (176) alignment 
Range on Protein: 884-1103
Range on HMM: 2-174/176.0
PLKPIHEEPGSDYINASFMPGLWspqeFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCThghlrvtlvgeevmenwtvr
.|.........|||||... | .    .||||||||.|. ||.....|.. ...|.||...| ||.|| .|||.  ..                      
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

ellllqveeqktlsvrQFHYQAWPDHGVPSSpDTLLAFWRMLRQWLDQtmeGGPPIVHCSAGVGRTGTLIALDVLLRqlqsEGLLGPFSFVRKMRESRP-
                |...  |||||||.. . || . ...|..|..   ||| .||||||.||||||.|.. | .    |  | ..  ....|| || 
................qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRpl

LMVQTEAQYVFLHQCILRFLQ
 .|||..|| ||....|..|.
gavqtpeQyrflyefellllk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 857-1101 1.4e-45 150.2 In-house 44-282 (290) alignment 
Range on Protein: 857-1101
Range on HMM: 44-282/290.0
SQMVASASEN---NAKNRYRNVLPYDWSRVPLKPIHeePGsDYINASFMPGLWSPqeFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEH
 ..  .  ..     ||||..|   | .|| ||  .  .| ||. | .. || ..  || |||.| .|| |.||.| ...  ..||| . .| |. |||.
qylerkifdkntefkknrykdvvcndktrvilkdGy..dG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceq

YWPL-DSQPCTHGHLRVTLVGEEVMENWTVRE-LLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPdtlLAFWRMLRQWldQTMeGGPPIVHCSAGVGRTGT
|.|  . .  | |.. |.   |.  .. ...  | . .... |   .. .. ..|||. |. |    ||. |.||    ...  || .||||||.|||||
yypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlril..rka.sGpvvvhcsaGiGrtGt

LIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF
..|..| |. |     | .   || .|.||   || . ||. | . .| .
fvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0049772 (Phosphotyrosine protein) phosphatases II 857-1103 4.4e-45 150.1 In-house 37-281 (314) alignment 
Range on Protein: 857-1103
Range on HMM: 37-281/314.0
SQMVASASENNAKNRYRNVLPYDwSRVPLkPIHEEPGSDYINASFMPGLwspQEFIATQGPLPQTVGDF----------WRLV--WEQQSHTLVM-----
. .||.  .|  |||| ..||.| .|| | |  .  ||||||||.. |    . ||||||||. || ||          ||.|  ........||     
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTNCMEAGrvkcehywpldsqpcthghlrV----------TlvgeevmenwtvrellllQVE---EQKTLSVRQFHYQAWPDHG
                |..... |                                                   ..    |  .  . ....  .||..
ladelsrLdaAlgKtpllildgng.....................neptaadlellk..................eelydpelferlgikylripvpDgs

VPsSPDTLLAFWRMLRQWldqtMEGGPPIVHCSAGVGRTGTLIALDVLLRQLqseGLlGPFSFVRKMRESRP-----LMVQTEAQYVFLHQCILRFLQ
.| ... ...| ......     .||| .|||.||.|||||..... |...|   |.  .   .. .|. ||      ....  ||.| ....| .|.
ap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
0049260 (Phosphotyrosine protein) phosphatases II 901-1096 1.3e-42 140.4 In-house 1-144 (152) alignment 
Range on Protein: 901-1096
Range on HMM: 1-144/152.0
FMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWpldsqpcthghlrvtlvgeevmenwtvrellllqveeqktlsvrQ
|..| . |.||||||||.|.|. ||||...|.. .|.||||...| |..|||.|.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FHYQAWPDHGVPSSPDTLLAFWRMLRQWldQTMEGGPPIVHCSAGVGRTGTLIALDVLLrqlqseGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ
...  |||||||.... || . ......  .  .||| .|||||||||||||.|.. .|        . .. .|. .|| || .|... |. ||..
ylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 850-1102 4.8e-42 138.8 In-house 15-295 (297) alignment 
Range on Protein: 850-1102
Range on HMM: 15-295/297.0
SLVGHSQSQMVASASENNA--KNRYRNVLPYDWSRVPLKpiHEEPGSDYINASFM--PGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCME
.|.  ....  .||  |..  |||||..| .| .|| |.     ...||||| ..  |   ..  .| .|||| .|| |||.||.||.  ..||...  |
llldeargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe

AGRVKCEHYWPLD-SQPCTHGHLRVTLVGEEVME--NWTVRELLLLQVeeQKTLSVRQFHYQAWPDHGVPSSPDTLLAF----------WRMLRQWLD--
 || ||  |||    .  . |.. |  . .   |  .  . || |.    ...  ||   . .||||||||  . |  |            |.   ..  
dGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemf

--------QTME-----GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
        ....       . .|||||||||.| ..  ||.| .|. . .    ......|| |. .|||  |. .|.. .|. |
tamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 843-1102 6.6e-42 138.6 In-house 19-277 (307) alignment 
Range on Protein: 843-1102
Range on HMM: 19-277/307.0
ADEYQQLSLVGhSQSQMVASASENNAKNRYRNVLPYDWSRVPLKpiHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTN
 ||...|.     ..  | . | |. ||||..|   | .|. .|   .   |||| | ..     |. ||..|||| .|. .|| .. ...  ...|| .
vdefrvlakkt.pegvtveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

CMEAGRVKCEHYWPLD-SQPCTHGHLR----VTLVGEEVME-NWTVRELLLLQV-EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAfwrMLRQwldQTMEG
..| ...||| ||||.  |  ..|.      |. .| . .  .  . ..  |.|   ||. ..... .. |||.|||    | .    .|        . 
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltain...llea...vrydt

GPPIVHCSAGVGRTGTLIALDVLL-RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
 | .|||||||||.||..|. ..  . .. .       .|...|. |.  .||||||..||. .| ..
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_ptpA1_pd Subfamily ptpA1 862-1063 8.6e-40 131.7 In-house 43-257 (418) alignment 
Range on Protein: 862-1063
Range on HMM: 43-257/418.0
SASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWsPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSqp
    | .|||| |.|| . .|| || |... ||||||| .. | . |..||.||||||.|. ||||.|||.. . .|||.   |  |.||..||| .   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi..

cTHGHLRVTLVGEEVMENWTV----------RELLLLQV---EEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRML----RQWLDQTMEGGPPIVHCSA
    .. .   |.||.  ..|          ||..  ..    | .|  . |..|. |||| .|   . .  . . .     | .  .    | ||||||
.ggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

GVGRTGTLIALDVLLRQLQ
|||||||. .  .....|.
gvgrtgtfctavimmkkld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 861-1102 1.1e-39 130.9 In-house 50-289 (305) alignment 
Range on Protein: 861-1102
Range on HMM: 50-289/305.0
ASASENNAKNRYRNVLPYDWSRVPLKpihEEPGSDYINASFMPGLWSP-QEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDS
 ||  . .||||..|   | | | |.   . . |||| | ..     | . ||..|||| ||. .|| .| ...   .||| . .| |..|| .|||.  
qsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

---QPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE--QKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwldqtmEGGPPIVHCSAGVGRTGTLIA
   .    | .   . |   ||  .  .. ||..    ....|||....  ||| |||    | | .   .|          | .||||||.|||||..|
geklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg......skvpivvhcsagigrtgtiva

LDVLLRQLQSEGLLGPF-SFVRKMRESRPLMVQTEAQYVFLHQCILRFL
.. .| ..  .    |.  .|. .|. |   .|.. ||.|.|. .| ..
ieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 836-1103 5.5e-39 128.8 In-house 2-260 (267) alignment 
Range on Protein: 836-1103
Range on HMM: 2-260/267.0
RDSNCGFADEYQQLSLVGHSQSQMVA-SASENNAKNRYRNVLPYDWSRVPLKPIHEEpgsdYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQS
 |..| .  |....  . . .|..    |..|...||. ..|||| .||.|.   ||    |||||.. |    . ||.||.|| .|..||. .. .|. 
edeeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkv

HTLVMLTNCMEAgrvKCEHYWPLD-SQPCTHGHLRVTLVGEEVMENWTVRElLLLQVEEQKTLSVRQFHYQAWPDHgVPSSPdTLLAFWRMLRQwlDQTM
 . |.||.  .    .   .||    |   .  | |    |.  ... .   | |..... .  |  ..|. |    .   |  |  .. .| .  .|  
pvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiit.lelkfknesahnvtlyyykkwnin.tnnkp.ylkplfgilak..nqle

EGGPPI-VHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
.|..|. |.||.||||.||.. .|  |.... || .  | |.||.|. |. .|.|  .|...|. .  . .
ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 862-1105 1.1e-38 127.7 In-house 44-290 (305) alignment 
Range on Protein: 862-1105
Range on HMM: 44-290/305.0
SASENNAKNRYRNVLPYDWSRVPLKPIHeepGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQP
  .... ||||..|   |  || |..       .|| | ..     |. || || || .|  ||| . .... ... || | .| |  || .|.. . ..
keaqeagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

CTH---GHLRVTLVGEEVME-------NWTVR-ELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRqwldqtMEGGPPIVHCSAGVGRTG
  .   .  ....  |   .       . .|.   |...   .|.. | ..|.  ||| |||..  ..| .    |         || .||||||.||||
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrtg

TLIALDVLLRQLQSEGLLGP-FSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS
... |. .| || .   .      ..|.|| |   .||.|||.|.|| || .... 
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 856-1104 1.8e-37 123.9 In-house 33-273 (288) alignment 
Range on Protein: 856-1104
Range on HMM: 33-273/288.0
QSQMVASASENNAKNRYRNVLPYDWSRVPLKpiheEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW
. ... |  .| ...||.|.   |..|| |.    .    ||.|  ..    .. .| .| ||  |.. .|... |.. . .|||.. .| |. | ..|.
sidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyf

PLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVE--EQKTLSVRQFHYQAWPDHGVPsspDTLLAFWRMLRQWldqTMEGGPPIVHCSAGVGRTGTLI
|.     ..     | | ..  .   . .. ||...   ...  |.. |.. |.|.|||   .  |.. |.|           | .||.|||||||||||
PsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP...enylsplrllevl...kslqkPivvhssaGvGrtgtli

ALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQ
   . |..|...  ||  |.. |.||.|   .||| ||...|.|.|  | .
lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 844-1101 2.8e-37 122.9 In-house 15-268 (281) alignment 
Range on Protein: 844-1101
Range on HMM: 15-268/281.0
DEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKP-IHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTN
.|. .|     |.   |     || |||| |.   | ||| ||  . ..  .||| | ..   .  . .| ||||  .|  ||||..|.... ..||| .
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

CMEAGRVKCEHYWPLDSQPCTHGHlRVTLVGEEVMENW-TVRELLLLQVeEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwldqtmEGGPPIVH
 .|. | ||  |.| ... | .   ....  |.   |   |   | |   | .|  . .. .. |||  || | . .|   | .|          ||..|
fletnrekcaeyfprnahcclqfd.klsvsyedstvnkslvttrlnlsy.egetrlithwlwkewpdwqvpessevmlkilrkira......rstppvih

CSAGVGRTGTLIALDVLLRQLQSEGLLGPF-SFVRKMRE-SRPLMVQTEAQYVFLHQCILRF
|||||||.|||.|... |. ..|   |      | ..|   |   |||  ||... . .| |
csagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0044763 (Phosphotyrosine protein) phosphatases II 877-1105 6.5e-37 122.2 In-house 1-174 (178) alignment 
Range on Protein: 877-1105
Range on HMM: 1-174/178.0
PYDWSRVPLKPIHEEPGSDYINASFMPglwsPQEFIATQGPlpqtvGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQpcthghlrvtlvgeev
|.| .|| | ..  ...|||||||..     |  ......|      |...|..|.  ...|.||. .| |..|| .||| .                  
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

menwtvrellllqveeqktlsvRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDqtMEGGPPIVHCSAGVGRTGTLIALDVLLRQlqseGLlGPFSFVRK
                       |...  .||||||.... .|.| ......||   .||| .|||||||||.|||.|.. ....    ||  ... .. 
......................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

MRESRPlMVQTEAQYVFLHQCILRFLQQS
.|| || .|... |. .|... ||.|..|
vrerRp.ivpnpgqlrqLyefelrllkes
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 841-1105 1.9e-34 113.6 In-house 28-293 (310) alignment 
Range on Protein: 841-1105
Range on HMM: 28-293/310.0
GFADEYQQLSLVGHSqSQMVASASENNAKNRYRNVLPYDWSRVPLKpIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVML
|.. .|..|     | |    .  ..  |||| .|.  | ||| || |      ||| | ..   .  . || .|||| .|. ||||....... ....|
glvkqyrkldakqds.sltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVmENWTVRELLL------LQVEEQ----KTLSVRQFHYQAWPDHGVPSSPDtllafwRMLRQWLD
 . .| || ||  |||      |.| .||| ..|   |.. . .| .      . |.||    | | |   ..  ||| |||            . | | 
ckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpqrll

QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQS
  .  || .||||||..|.....||.. . .|.    .     . ... ||   .||| ||.....  . | .  
aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarge
PTPc_DSPc_SM00012 998-1099 2.2e-34 113.2 In-house 2-104 (105) alignment 
Range on Protein: 998-1099
Range on HMM: 2-104/105.0
VRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSE-GLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ
|...|| .|||||||...| .| . | ....  .  ...| .||||||||||||..|||.||.||..| . .  | .|...|..|| |||||.||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CIL
..|
all
0051082 (Phosphotyrosine protein) phosphatases II 893-1098 5.3e-34 112.3 In-house 2-149 (151) alignment 
Range on Protein: 893-1098
Range on HMM: 2-149/151.0
GSDYINASFMPGLwspqeFIATQGPLPqtvgDFWRLVWEQQSHTLVMLTNCMEAGrvKCEHYWPLDSqpcthghlrvtlvgeevmenwtvrellllqvee
 |||||.|.. |      .....|||.    ||..|..|..  | |.|.. .| |  .| .|.|  .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qktLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwldqtMEGGPPIVHCSAGVGRTGTLIALDVLLRQlqseglLGPFSFVRKMRESRPLMVQTEAQYV
   . |.....  |||.|.| |.|..|.|...|..     ...|| .||||||.||||||.||. .|..      . ... .. .|..|| .||.. |..
...ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FLHQCI
|.....
fqlfal
subfamily_CG42327_pd Subfamily CG42327 857-1022 1.8e-32 107.3 In-house 21-187 (319) alignment 
Range on Protein: 857-1022
Range on HMM: 21-187/319.0
SQMVASASEnnAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLW-SPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW
.  |  .|.   |.|. ||.|   .|| |. | ... . |..||.. |   .|  .||.| .| ..  ||||.|||||| ..| ||.  | |  .| .|.
adevPvtsk..dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeyl

PLDSQ---PCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYqAWPDHGVPSSPDTLLAFW
|         ..|...||| | || ... .  ||| .|.....  .  . |  |.. .||... .|.|  
PtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
0048076 (Phosphotyrosine protein) phosphatases II 988-1101 2.7e-27 90.6 In-house 37-142 (145) alignment 
Range on Protein: 988-1101
Range on HMM: 37-142/145.0
LQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQtmeGGPPIVHCSAGVGRTGTLIALDVLLRqlqsEGlLGPFSFVRKMRESRPLMVQT
   .|  .  . |..|  |||||||.....||.| ......|..   ||| .|||||||||||||.|....|.    .| . ... ....|. || .|..
tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpn

EAQYVFLHQCILRF
. |. ||....|..
pgqlrflyefelel
subfamily_egg_pd Subfamily egg 859-1117 4e-27 89.7 In-house 32-285 (307) alignment 
Range on Protein: 859-1117
Range on HMM: 32-285/307.0
MVASASEN-NAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAgrVKCEHYWPL
.  .||.|   | | . |   | ||| |.  .     |.| |  . |     ||| .| ||  || ||||.|.... . .||||   |.   .||.||| 
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

-DSQPCTH--GHLRVTLVGEEVME--NWTVRELLLLQVEeqktlsVRQFHYQAWPdHGVPSSPDTLlAFWRMLRQWLDQtmeGGPPIVHCSAGVGRTGTL
 .|..     | ||.. .. .      ..| .| |.  .        . . . |    |  | |      |.||.  .      | .|..  || ...||
aesdslvtvpGslrienlkvdskadplfrvtklklvGgd......deerflehwq.gdvnnssdvy.splrvlrklrnl...skpvvvqdilGvskaatl

IALDVLLRQLQSEGLLG-P-FSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYE
.|... | .|    .   .    |  .|  |.| |..  .|.|... .| |...   .  | .| ||
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdye
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 897-1094 5.3e-27 89.4 In-house 78-273 (301) alignment 
Range on Protein: 897-1094
Range on HMM: 78-273/301.0
INASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDS-QPCTHGHLRVTLVGEEVMENWTVRELLLLQVE---E
| | ..|    |. ||||||||..|  ||| ..   . ...|||.. .|    |||.| |..  .    |  ..... .|.. |  . .  |  ..   .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

QKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQwldqtmEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYV
 .| .|  . |. |.|.||| |   |  .  ....         | .||||||.||. ..|. ..| |.....  .     ....|| |   |||. |  
fatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

FL
..
wm
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 861-1101 1.8e-26 87.7 In-house 29-269 (285) alignment 
Range on Protein: 861-1101
Range on HMM: 29-269/285.0
ASASE-NNAKNRYRNVLPYDWSRVPLKPiHEepgSDYINASFM--PGLwSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPL
 .| | |   ||| .|   . .|| ||  |.    ||| ||.|  ||      .|.||||||.|. |||.......   ..||   .| |  ||  |.| 
ytayeanpdlnryadvrcieetrvvlkn.hd...rdyihaswmrmpgk.dqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

DS-QPCTHGHLRVTLV--GEEVMENWTVRELLLLQVEEQKTLSVRQFHYQ--AWPDHGVPSSPDTLLAFWRMLRQWldqTMEGGPPIVHCSAGVGRTGTL
   .    |.  .||    || .    .  | ... |.  .  .   | |   |||.  |     .. ... ...      .  |  |||||||||| |.
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv...npkekpicvhcsagvgrtatf

IALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF
. .|    ..  .  .  .  ||.||  |   ||.  |..||.  .. .
vgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
0048179 (Phosphotyrosine protein) phosphatases II 991-1096 7e-26 86.1 In-house 48-139 (144) alignment 
Range on Protein: 991-1096
Range on HMM: 48-139/144.0
EeqktlsVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDqtmEGGPPIVHCSAGVGRTGTLIALDVLLrqlqSEGlLGPFSFVRKMRESRPLMVQTEAQ
|      . |...  |||||||.... ||.| ......|.   |||| .|||||||||||||.|.....     .| | ... .. .|. || .|... |
e......giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

YVFLHQ
. ||..
lrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 868-1107 2.5e-24 80.6 In-house 45-281 (312) alignment 
Range on Protein: 868-1107
Range on HMM: 45-281/312.0
AKNRYRNVLPYDWSRVPLKPihEEpgSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHG--
  ||| |.  .|  |  |    .|    || | |.     |. |..||||| .|.  ||.|.    | ....|.  .| |  || .|             
dlnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

-----HLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLafwRMLRQWldqTMEGGPPIVHCSAGVGRTGTLIALDVLLR
     .     .|    .. | | | ..     .   . .. . .|||||.| | || |   |.|        .  | | ||||||||||||. .. .. 
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...rllsav...kkdkkpviahcsagvgrtgtlaliesmia

QL---QSEGLLGPFSFVRKmreSRPLMVQTEAQYVFLHQCILRFLQQSAQ
 |   . . .   | ..||    |   |.. .|||.  .|.| ||   . 
alrhprkqnvkdsfvllrk...drarsvrvfpqyvyalrcvleflyskgl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 858-959 1.2e-23 78.4 In-house 39-154 (350) alignment 
Range on Protein: 858-959
Range on HMM: 39-154/350.0
QMVASASENNAKNRYRNVLPYDWSRVPLK--------PIHEEPGSDYINASFMP----GLWSPQEF--IATQGPLPQTVGDFWRLVWEQQSHTLVMLTNC
 ....  |  |||||.|.|||. ||| ||          |   ..|||||...     .     .|  ||||.|||.|| ||.... . . . ...||. 
vilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsd

MEAGRVKCEHYWPLDS
.| .. ||..||.  |
velnlekcyrYWqegs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 996-1124 5.9e-23 75.9 In-house 89-215 (440) alignment 
Range on Protein: 996-1124
Range on HMM: 89-215/440.0
LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTmEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLH
 ...|.|||.|||.|||     .| . . . .  ...   || .||||||.|||| .||.| .||. .    .  |||.  ||..|| ||||  ||.|.|
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QCILRFLQQSAQAPAEKEVpYEDVENLIY
...|  |  .     | ..  | ||.. .
eavlegllcgdtlileddi.terveqiqw
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 864-1097 2.1e-18 61.0 In-house 45-274 (303) alignment 
Range on Protein: 864-1097
Range on HMM: 45-274/303.0
SENNAKNRYRNVLPYDWSRVPLKpiheepGSDYINASFMpGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDsQPCT
 .|  |||. .|.  | |.| |        | || ||..  | | .  | || ||..|  |||... ||. . ...|    |  ..  .  .| . |   
vknmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdfl

HGHLRVTLVGE----EVMENWTVRELLLLQvEEQKTLsVRQFHYQAWPDHGVPSS--PDTLLAFWRmLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDV
.   |.  |||    |... |... | . .  . |.. .   ||.|||   .||   |  .   |. |.  | .  .. |..    .|.||.||.  .. 
kfeersirvgefkrvelgdgwvlkvlsvsn.gdyksf.lhvhhykawphnsipsdgspkfvkqiwq.lqsvlrkysdstptvymslsgcgragtfalfet

LLRQLQSEG-LLGPFSFVRKMRESRPLMVQTEAQYVFLHQC
    |.||   |     . ..|. |   ||  .|. ...  
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 921-1103 1.1e-16 55.7 In-house 40-222 (255) alignment 
Range on Protein: 921-1103
Range on HMM: 40-222/255.0
TVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHlRVTLVGEEVMENWTVREL--LLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTL
||  |.. .  ......|||..  |.|..||..|.||. .     .  |...  . . .  .| |  ..   | .||  |. ..|. |...  |  .  .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LAFWRMLRQWldQtmeggPPIVHCSAGVGRTGTLIALDVLLR----QL--QSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ
|  ... |.   .     . .||||.|.||. ...  ... .    .|   . . |   |.....|..|.  ..|  |  |    .| .. 
lnilkvvrds..k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1039-1099 1.2e-16 54.8 In-house 2-62 (69) alignment 
Range on Protein: 1039-1099
Range on HMM: 2-62/69.0
IVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCIL
.||||.| |||||.||. | . ...|| |.  |  |. ||  ||.||  | .|.|.|  . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 910-1096 3.2e-16 54.1 In-house 5-197 (198) alignment 
Range on Protein: 910-1096
Range on HMM: 5-197/198.0
EFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPL-DSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE--QKTLSVRQFHYQAW
 .|||| || .|. |||..|||  |  .||. .      .    |||  .|    .| | ||     .  ..|.  |.| .       |  . .. . .|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPSSPdTLLAFW---RMLRQWLDQTMeGGPPIVHCSAGVGRTGTLIALDVLLRQLQS--EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ
 ..  |     .. |    | . .  .|     | ||||| | | || ..|||. .|  .     ..  |   ...|..|  .. .  .| |..|
kekttpnva.lfvgfvvasrevskkyeqek.dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 866-1110 3.5e-16 54.2 In-house 19-267 (290) alignment 
Range on Protein: 866-1110
Range on HMM: 19-267/290.0
NNAKNRYRNVLPYDwSRVPLKPIHEEPGSDYINASFMPgLWSPQEFIATQGPLPQT-------VGDFWRLVWEQQSHTLVMLTNCMEAGRV----KCEHY
.. ..|... |  . .||.||   .   .||| |...    . ...|.|| |. ..       . .|| .. . ... .||| . .|  .      |..|
hemdqRlevpLvea.trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPLDSQ-PCTHGHLRVTLVGEEVMENWTVRELlLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRqwldqtMEGGPPIVHCSAGVGRTGTLI
 |       . . | |     |  ..  .||| ... .... . |    .. | .  |. .. |||.  ....       .. | ||||  |. |  .| 
vpesvgeelkfkgltvkCkskekeddvetRel.vvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk......asktpvivHcvdGiSrsAala

ALDVLLRQLQ-SEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPA
|...    .  ..| .   . . ..|. | |..... .. |    |.  ...  .. |
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfa
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 910-1096 3.5e-16 54.0 In-house 6-198 (199) alignment 
Range on Protein: 910-1096
Range on HMM: 6-198/199.0
EFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPL-DSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE--QKTLSVRQFHYQAW
 .|||| || .|. |||..|||  |  .||. .      .    |||  .|    .| | ||     .  ..|.  |.| .       |  . .. . .|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPSSPdTLLAFW---RMLRQWLDQTMeGGPPIVHCSAGVGRTGTLIALDVLLRQLQS--EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ
 ..  |     .. |    | . .  .|     | ||||| | | || ..|||. .|  .     ..  |   ...|..|  .. .  .| |..|
kekttpnva.lfvgfvvasrevskkyeqek.dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1039-1100 4e-16 53.1 In-house 1-62 (69) alignment 
Range on Protein: 1039-1100
Range on HMM: 1-62/69.0
IVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR
.||||.| |||||.||. | . ...|| |.  |  |. ||  ||.||  | .|.|.|. .  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 918-1102 4.6e-16 53.1 In-house 100-288 (302) alignment 
Range on Protein: 918-1102
Range on HMM: 100-288/302.0
LPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQ-PCTHGHLRVTLVG-EEVMENWTVRE-LLLLQV-------EEQKTLSVRQFHYQAWP
  .|.  .| |. . .    | |.. .| .  || .|.  . .   . |.  |. |  .. .|..| .. . | .|       ....  .|  ... |||
kkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawp

DHGVPSSPDTLLAFWRMLRQWLDQTmeggppIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
||| |  ..| |   .    .  .       .|||||||||||||.|.   .   . .      | |  .|. |   ||.| | ..|  |. . |
dhGapkeaytaldilkfcesykknv......lvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 859-1010 1.2e-15 51.8 In-house 88-234 (244) alignment 
Range on Protein: 859-1010
Range on HMM: 88-234/244.0
MV-ASASENNAKNRYRNVLPYDWSRVPLKpiHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAgrvkcEHYWPl
|  |   .|. |||    ||.|..||||   .   |  ||||||.  |    |.| || || .|  |||... |.    ||.|    |      . ||| 
mkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp.

DSQPCTH--GHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHG
||.|       . |||   . . |    .| .    ..   ..  |    ||  |
dseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_hpo-7_pd Subfamily hpo-7 918-1119 3.6e-15 50.6 In-house 43-243 (263) alignment 
Range on Protein: 918-1119
Range on HMM: 43-243/263.0
LPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHlRVTLVGEEVMENWTVRELLLLQ-VE-EQKTLSVRQFHYQAWPDHGVPSSP
| ||.  |.. .  ......|||..  |.|..||..|.||.       .  |...  .|...  .. | ||. ..  .||  |... |. |...  |  .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

DTLLAFWRMLRQWldQTMeggppIVHCSAGVGRTGTLIALDVLLR----QL--QSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSaQAP
   |   .. |.   . .     .||||.|.||.      ... .    .|   | . |   |.....|.||.  ..|  |  |    .| |. ..  | 
reilnilkvarns..ksl.....vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn.fak

AEKEVPYEDV
 | |  |...
geleakyqei
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 824-906 4.4e-15 49.9 In-house 8-87 (440) alignment 
Range on Protein: 824-906
Range on HMM: 8-87/440.0
AEDFADHVRKNERDSncGFADEYQQLSlVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLW
  ||||.|..| |     | ||.  |   | ||   .||  .|. ||||||.| || ||| |. ..  | |||||||.. |. 
vadfadyvqnnrrsr..afedewsllp.sglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_eak_pd Subfamily eak 856-1026 5.7e-15 49.5 In-house 42-208 (332) alignment 
Range on Protein: 856-1026
Range on HMM: 42-208/332.0
QSQMVASASENNAKNrYRNVLPYDWSRVPLKPIHEEPgSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW
.|. ...  |.  .|   ...|||   | | .   ..   ||||| .      ...| |  .  . |  ||..| ||.| ..|.| . .| .  | . |.
lsisetarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PLDS-QPCTHGHLRVTLVGEeVMENWTVRELLLLQVEeQKTLSVRQFHYQAWPDHGVPSSPDtLLAFWRMLR
| .. .   .|.| |.     | .|     || |..   .|  |  ...  | .  .|   | .||. ....
pdktreelkfGildverkef.vkrniletrllelskG.nethrvlhykvfGwtettlpkyed.flalrkvmk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 857-956 1.1e-14 48.5 In-house 39-154 (349) alignment 
Range on Protein: 857-956
Range on HMM: 39-154/349.0
SQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEP--------------GSDYINASFM--PGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVML
  ....  |  |||||...|||. ||| ||   . .                ||||| ..  . .   . .|||| ||| || ||....  .. . .. |
dvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

TNCMEAGRVKCEHYWP
..  | .  ||. || 
nddkelslekcdiywq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 864-1113 1.1e-14 48.6 In-house 49-296 (302) alignment 
Range on Protein: 864-1113
Range on HMM: 49-296/302.0
SENNAKNRYRNVLPYDWSRVPLKpiheEPGSDYINASFM--PGLWspQEFIATQGPLPQTV---GDFWRLVWEQQSHTLVMLTNCMEAGRvKCEHYWPLD
 .| .||.  .|  .|  .| |.    .   .|.||| .  | |   .. | .| |  ...    .|||.|....  ..|.|    |  .   ....|. 
kknlkknqsedvpildsnlvkle....aepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

SQ-PCTHGHLRVTLVGEEVMENWT---VRELLLLQVEEQKTLSVRqfHYQAWPDHGVPSSPDTLLAFWRMLrqwLDQTMEG-GPPIVHCSAGVGRTGTLI
|.   ..|...|     | .|. .   | |.|   . .    .|   . . |... || .  .| .    .    ......  . ..    |.|| |...
sgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafl

ALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKE
.| | . .||..        |...|. || .|..  |||.|. ..| ....  . |.||.
tlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 995-1102 2.4e-13 44.6 In-house 214-344 (350) alignment 
Range on Protein: 995-1102
Range on HMM: 214-344/350.0
TLSVRQFHYQAWPDHGVPSSPDTLLAFWR--------MLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLR------QLQSE--------GLLGP-F
 . | |.... |.| ..   |  .|            .  .   .. .. | .|||||||||||||..|| ||       .|. |         .  . .
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

SFVRKMRESRPLMVQTEAQYVFLHQCILRFL
  | ..|. |  |||.  |..|.....| . 
iivnelrkqrismvqnldqfifiYeallfyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 910-992 1.1e-12 42.0 In-house 237-316 (440) alignment 
Range on Protein: 910-992
Range on HMM: 237-316/440.0
EFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEagrVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE
 ||||| ||  || |||||| . .  |..|| .  .     |  |||....  | | . |   | | |.   || | |   ||
afiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee
subfamily_CG42327_pd Subfamily CG42327 1035-1101 3.2e-11 37.5 In-house 247-314 (319) alignment 
Range on Protein: 1035-1101
Range on HMM: 247-314/319.0
GGPPIVHCSAGVGRTGTLIALDVLLRQLQSE-GLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF
 || .|||| ||||||..|| |. .|.|.     .     |  .|. |   |.|  || |... .  .
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
0038934 (Phosphotyrosine protein) phosphatases II 1000-1094 5.1e-11 38.0 In-house 81-169 (194) alignment 
Range on Protein: 1000-1094
Range on HMM: 81-169/194.0
QFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTmEGGPPIVHCSAGVGRTGTLIALDVLLRqlqsEGLlGPFSFVRKMRESRPLMVQTEAQYVFL
...   .||.|.. | ..|| | ... ..|..  .||   ||| ||.||||||.|   . |     |.  .   .. .|| || ....  ..  |
eylklpfpddgtvPsleillrfldlvdeflned.pggvvaVHCkaGlgRtGtlvaaYLiyr....lgm.saeeAialfrekRpgaipnqdyleal
fn3 Fibronectin type III domain 53-122 5.2e-11 35.7 Pfam-A 2-74 (85) alignment 
Range on Protein: 53-122
Range on HMM: 2-74/85.0
NPgRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGT--TETRNT--TATNVTVDGLGPGSLYTCSVW
 | .||.|. .|..|..|||. |.  ... ..| |..  .||.  . ....  |.|.||. || ||. |...| 
aP.enlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq
fn3 Fibronectin type III domain 590-672 5.6e-11 35.6 Pfam-A 3-78 (85) alignment 
Range on Protein: 590-672
Range on HMM: 3-78/85.0
VTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRrgqdpqaNWVNQTSRTNETWYKVEALEPGTLYNFTVWAERN
...|. . .| .|..| |..| |.....  | |....||...        |...|   ..| .... |.||| |.|.| |  .
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavng
fn3 Fibronectin type III domain 232-300 8.7e-11 35.0 Pfam-A 2-74 (85) alignment 
Range on Protein: 232-300
Range on HMM: 2-74/85.0
PVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGD--GG-RTETRNTTDT-RVTVDGLGPGSLYTCSVW
...||.|...|..|..|||. |.  . . . | |..  .  |.  .| ... .| .||. || ||. |...| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq
fn3 Fibronectin type III domain 410-484 1e-10 34.8 Pfam-A 2-80 (85) alignment 
Range on Protein: 410-484
Range on HMM: 2-80/85.0
PVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGG--TETRNTTNTS--VTAERLEPGTLYTFSVWAEKNGA
...||... .|..|. | |. |. .  ..  | |||  .|||  . ......|.  || . |.||| |.|.| | ... 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 876-1010 1.1e-10 35.9 In-house 3-125 (130) alignment 
Range on Protein: 876-1010
Range on HMM: 3-125/130.0
LPYDWSRVPlkpiheepGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAgrvkcEHYWPlDSQPCT--HGHLRVTLVG
|... ||..        | .||||||.  |   .|.. || || .|  |||... |.    ||.|    |      . ||| ||.|      .. |||  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp.dsePlewyeediivtltd

EEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHG
 . ..|    .|   .   .   ..  |.   ||  |
rdefknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 827-916 1.3e-10 35.3 In-house 10-95 (95) alignment 
Range on Protein: 827-916
Range on HMM: 10-95/95.0
FADHVRKNERDSNCGFADEYQQLSLVGHSqSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEepgSDYINASFMPGLWSPQEFIATQG
|  || .   .|.  | .|.. .|.   . .  | |.  |  |||. |..||| .|| |    .   |||||| |. |    . .||.||
fhshvlemhsnsdqefdnefksismtsga.pytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 846-936 1.7e-09 31.7 In-house 16-112 (347) alignment 
Range on Protein: 846-936
Range on HMM: 16-112/347.0
YQQLSLVGHSQSQMVASASENN-AKNRYRNVLPYDWSRVPLKPIHEE-----PGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT
| .  | ..| |.. ..  |.. .||| ..|   | .|| | | . .     .   ||||| .    . .|.| || |||.|| |||..|   .   
yfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtq
fn3 Fibronectin type III domain 321-388 4.1e-09 29.7 Pfam-A 2-73 (85) alignment 
Range on Protein: 321-388
Range on HMM: 2-73/85.0
PVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGD--GG--RAGTRSTAHTNITVDRLEPGCLYVFSV
...||.|...|..|. |.|. |. .. . . | |||  .  |.  .  |..  .|. |.  |.||  |.|.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrV
subfamily_PTPDC1_pd Subfamily PTPDC1 1001-1097 5.9e-09 30.6 In-house 85-171 (182) alignment 
Range on Protein: 1001-1097
Range on HMM: 85-171/182.0
FHYQAWPDHGVPSsPDTLLAFWRMLrqwlDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLqseglLGPFSFVRKMRESRPLMVQTEAQYVFLHQC
..  .|.|.||.|  ...|   ...    ..... |   ||| || |||| |||  ..  .      | .   ....|. ||  .||  |  .... 
vynfgwkDygvas.leriLdivkvv....afalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvkef
fn3 Fibronectin type III domain 143-209 8.9e-09 28.6 Pfam-A 2-72 (85) alignment 
Range on Protein: 143-209
Range on HMM: 2-72/85.0
PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGD--GG--RAGTRSTAHTNITVDGLEPGCLYAFS
...||.|...|..|. |.|. |. .. . . | |||  .  |.  .  |..  .|. |. ||.||  | |.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 990-1102 1.4e-08 28.5 In-house 212-344 (349) alignment 
Range on Protein: 990-1102
Range on HMM: 212-344/349.0
VEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLD--------QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQL---Q--SE-----GL-LGP
....|   . |. .. |.| ..   | ..|    .  . .|        .| .  . .|||||| ||||.|. ||.||  |   |  |       |   .
lavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDl

-FSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
 .  | ..|  |  |||  ||........|...
isiivnelrkqrismvqnlaqfiaiyealLkyf
PTEN_1 1000-1054 7.5e-08 27.4 In-house 96-149 (196) alignment 
Range on Protein: 1000-1054
Range on HMM: 96-149/196.0
QFHYQAWPDHGVPSsPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIA
...   ..|||.||  . |... . . .|| .  .|.  .||| ||.||.||..|
eylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 858-1016 3.1e-07 23.4 In-house 19-159 (169) alignment 
Range on Protein: 858-1016
Range on HMM: 19-159/169.0
QMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINAsfmpglwspqefiatqgplpqtvgdfwRLVWEQQSHTLVMLTNCMEAGRVKCEH--Y-
...|  . |..|||    |     || |. . |. |||||||                           |..|| ..  .|.| .. .      |.  | 
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyq

---------WPLDSQPCTHGHLRVTLVGEEvmeNWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPD
         |  ||      ....   | |         ... . ... |  .. .|| .||. ||| || 
lhpavilgewytdslyvrtdkvhantsgve...glfevsmvihsydddvteklsllhystwpqngvpqspv
fn3 Fibronectin type III domain 499-573 3.4e-07 23.5 Pfam-A 2-79 (85) alignment 
Range on Protein: 499-573
Range on HMM: 2-79/85.0
AVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTD-PRTQSTSGTD--ITLKELEAGSLYHLTVWAERNE
|.. ||  . |.... |.|..|. .|.   .| | .  .| .. ........|    ||..|..|. |...| |  ..
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 858-1016 5e-07 22.7 In-house 18-158 (169) alignment 
Range on Protein: 858-1016
Range on HMM: 18-158/169.0
QMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINAsfmpglwspqefiatqgplpqtvgdfwRLVWEQQSHTLVMLTNCMEAGRvkcehYWPL
...|  . |..|||    |     || |. . |. |||||||                           |..|| ..  .|.| .. .        .|| 
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknn.....fwpe

DSQPCTHG------------HLRVTLVGEEV--MENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPD
  .   |             ..|   |  ..  .|      |.. . ... |  .. .|| .||. ||| || 
kedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv
Syndecan Syndecan domain 774-801 8.7e-06 13.4 Pfam-A 12-39 (64) alignment 
Range on Protein: 774-801
Range on HMM: 12-39/64.0
AGVIAGAFVGILLFLILVGLLIFFLKRR
|.||||. ||.|   .||..|.. ....
aavIaggvvgllfAvllvlflvyRmrKK