Gene PTPRJ in Homo sapiens

Synonym: CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, PTPRJ

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP092_AA protein Get Run
HsapP092_AA_1023-1300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 1016-1305 1.9e-131 432.5 In-house 2-291 (293) alignment
Range on Protein: 1016-1305
Range on HMM: 2-291/293.0
KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQG
|||| |..|.||...||..|||...|.||||.||.|| .| . |||||.|| ||||.|.|||| ||||| .....|..|||||||.|||.|...||||||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK-QAQDYGDITVAMTSEIVLPEWTIRDFTVKNiqTSESHPLRQFHFTSWPDHGVPDTTD
|||.|..|||||||||.. .|.|||..||.|..|||||||.. ... ||||.| ...| .| .|.||......  ..|.. .||.|||||||||||..|.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektk

LLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
 |..| . ||......  ..||.|||||||||||||||.|||. .||.|..||..|||..||..| |.||||.||.|..|||||..|.....
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeee

subfamily_PTPRD_pd Subfamily PTPRD 1018-1304 1.4e-115 382.1 In-house 2-286 (564) alignment
Range on Protein: 1018-1304
Range on HMM: 2-286/564.0
SKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVgISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPL
|| | |........| .|.|.  | |||....    . .. ||.  .|. ||||.|...|| |||.| .|. ..  |||||... ||...| .|||||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLI
..|..||||||||.|.  |.||||..|.|..||..|||.|. . ||..|| ...|  | . .||.|..|. ..|||.  ||||||||||||||...  |.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

NFRYLVRDYMkQsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
...  ||..  . | . ||.||||||||||||||.|| .. .|..|.|||.|..|  || .|. |||||.||.|. . .|. . ....
dlirkvraln.e.pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

0050432 (Phosphotyrosine protein) phosphatases II 1016-1300 1e-105 348.7 In-house 21-300 (308) alignment
Range on Protein: 1016-1300
Range on HMM: 21-300/308.0
KKSKLIRVENFEAYFKKqqADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvqtHSTDDYINANYMPGY--HSKKDFIATQ
..|. ..|...  ...|  |... .. ||.|.|  | .. . ..|.| ||. |||| ..|||| |||||    ....|||||.|..||  .... |||||
vsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatq

GPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK---QAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPD
||||||..|||||||| ||  |.||||.|| || ||..|||..   . . ||..|| ..|| ||...|.| ....|....||. ...||.|.|||||||.
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

TTDLLINFRYLVRDYMkqspPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
 .. |..|  |||...    |..||.|||||||||||||||.| |. |.| |..|||...|. ||..|| ||||..||.|| ...|....
speilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0051299 (Phosphotyrosine protein) phosphatases II 1019-1298 3.6e-105 346.8 In-house 3-285 (288) alignment
Range on Protein: 1019-1298
Range on HMM: 3-285/288.0
KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLP
. |.||... ...| .|....|..||.|.|  . .. . .|| | ||. |||| ..|||| |||||||    ...|||||.|..||..|. |||||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNI----QTSESHPLRQFHFTSWPDHGVPDTTD
||..||||||||.||  |.||||.|| ||.||. |||... . |||||| ..|| ||...|.| ..|.|.    ...||.  ..||.|.||||||||...
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

LLINFRYLVRDYMKqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
||..|  |||....  ....|..|||||||||||||||.| |..|.|.|..|||...|  ||..|| ||||..||.|. ...|. 
llldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1021-1303 3.8e-105 346.5 In-house 2-284 (318) alignment
Range on Protein: 1021-1303
Range on HMM: 2-284/318.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNT
| ||..|   .. ... .  . |||| |. .  .  .. .    |. ||||.|.|.|| .||||. .. . . |||||||..||..|| .||.|.|||.|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
..||||||||.|   |.|||...|.|..|.. |||||... ||...| ...|. | ....| |.|.. ...||   ||.|.|||||.|||. .  |... 
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

YLVRdYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
  |. ...|.. ..||.|||||||||||.|||.| |. .|..|..|||...|  || .|.|||||||||.|. . .|. . | .
rqvs.kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

0036941 (Phosphotyrosine protein) phosphatases II 1029-1301 5.2e-101 333.1 In-house 3-279 (297) alignment
Range on Protein: 1029-1301
Range on HMM: 3-279/297.0
YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvqTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVW
. .. ..... .. .|.|.|  . .. ....|.| ||. |||| ..|||| .||||   ... .|||||.|..||. |. |||||||||||. |||||||
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EKNVYAIIMLTKCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIV--LPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRD
| ||  |.|||..|| || ||..|||..  . . |||.|| ..|. |  |...|.| ..|......||. ...||.|.|||||||.... |..|  |||.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

YMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE---NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
..|..|...|.||||||||||.|||||.| ...|.|    |..||.. .|  ||..|| .|||..||.|| ...|. ...
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

0047943 (Phosphotyrosine protein) phosphatases II 1031-1297 6.2e-101 332.7 In-house 4-270 (273) alignment
Range on Protein: 1031-1297
Range on HMM: 4-270/273.0
KKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvqTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEK
. ...... ...||.|.|. . .. ....|.| ||. |||| ..|||| |||||   .....|||||.|..||..|. |||||||||||..||||||||.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NVYAIIMLTKCVEQGRTKCEEYWPSKQ---AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMK
||  |.|||..|| || ||. |||...    . ||..|| ..|| . . .|.| ....|..|.||.  ..||.|.|||||||.... |..|  |||....
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
..| ..|..|||||||||||||||.| |..|.| |..|||. .|. ||..|| ||||..||.|| ...|.
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0046845 (Phosphotyrosine protein) phosphatases II 1040-1300 3.5e-100 330.3 In-house 1-275 (284) alignment
Range on Protein: 1040-1300
Range on HMM: 1-275/284.0
GFAEEYEDLKLVGISQ--PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH--STDDYINANYMPGY-----HSKKDFIATQGPLPNTLKDFWRMVWEK
|. ||.| |  . ...  . ..| | ||. |||| ..|||| |||||..  .  ...|||||.|..||     ..|| |||||||||||..||||||||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ
||  |.|||..|| ||.||. |||...  . |||.|| ..|| | . .|.| ....|.. |.||. ...||.|||||||||.... |..|  |||.....
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

SPPESPILVHCSAGVGRTGTFIAIDRLIYQIENEN---TVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
.|...||.|||||||||||||||.| |..|.|.|.   .|||...|. ||..|| ||||..||.|. ...|. ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0040438 (Phosphotyrosine protein) phosphatases II 1024-1300 1.7e-99 328.3 In-house 3-277 (317) alignment
Range on Protein: 1024-1300
Range on HMM: 3-277/317.0
ENFEAYFKKQQADSNCGFAEEYEDLKLVGISqPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKD
.... . ..  . .. .. ||.|||  . .. .   ||| ||..|||| ..|||| ||||||. .    .|||||.|..|.. |. |||||||||||. |
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLV
||||||| .|  |.|||...| || ||..|||... . |||.|| ..||..|...|.| ..|.. ..|||. ...||.|.|||||||...|||..|  .|
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

RDYMKqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
|....  .|..|.||||||||||||||||......|.| |..|||. .|. ||..|| .|||..||.|| ...|....
reale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

0039614 (Phosphotyrosine protein) phosphatases II 1016-1300 7.2e-99 326.2 In-house 9-290 (297) alignment
Range on Protein: 1016-1300
Range on HMM: 9-290/297.0
KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISqpKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH--STDDYINANYMPGYHS-KKDFIAT
..| .|... ....... .|.|. .. .|.|.|. . ..  .. |.| ||. |||| ..|||| |||||..  .    .|||||.|..||.  ...||||
lesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWPSKQAqDYGDITVAMTSEIVLPEWTIRDFTVKNiqTSESHPLRQFHFTSWPDHGVPDTT
|||||.|..|||||||| .| .|.||||.|| || ||..|||...   |||.|| ......|. .|.| ..|.|  ..||. ...|..|.|||||||...
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsl

DLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
.||..|  |||......|.. |.||||||||||||||||......|.| | .|||. .|  ||..|| .|||..||.|| ...|. ..
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0045450 (Phosphotyrosine protein) phosphatases II 1016-1298 1.5e-97 322.3 In-house 4-303 (307) alignment
Range on Protein: 1016-1298
Range on HMM: 4-303/307.0
KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGI--SQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH--STDDYINANYM--------PGY
. |..|...... .......|.. |...|.|.|. | .  . . ..|.| ||. |||| ..|||| .|||||. ..  ...|||||.|.        .||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK-QAQDYGDITVAMTSEIVLPEWTIRDFTVKNI-QTSESHPLRQFHFT
..|. |||||||||.|..|||||.||..| .|.|||..|| || || .|||.. . . ||..|| ..|| .|...|.| ..|..  .|.||. ...||.|
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

SWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
.|||||||.... |..|  .||......|...|.||||||||||||||||.. ...|.|.|.|   ||.. .|  ||..|| .||...||.|| ...|. 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel





0043336 (Phosphotyrosine protein) phosphatases II 1022-1297 9.9e-97 319.0 In-house 3-275 (278) alignment
Range on Protein: 1022-1297
Range on HMM: 3-275/278.0
RVENFEAYFKKQQADSNCGFAEEYEDLKLVGIsQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTL
.|.... ....  .... .. .|.|.|  . .  ... |.| ||. |||| ..|||| ||||||. .    .|||||.|..||. ...|||||||||.|.
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPsKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRY
.|||||||| .|  |.|||..|| ||.|| .||| .. . |||.|| ...|..|. .|.|...|.| ...||.  ...|...|||||||....||..|  
edFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

LVRDYMKqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
 ||....  ....|.||||||||||||||||...|..|.|.| .||.. .| .||..|| .|||..||.|| ...|.
avreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1028-1301 1.7e-94 311.1 In-house 4-278 (281) alignment
Range on Protein: 1028-1301
Range on HMM: 4-278/281.0
AYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRM
. .|......| ||.||||.|. .|....  |..  ||. ||||.|.  || .|||.. . . .. ||||||..|||...|..||||||.|..|..||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPEWTIRDFTVkNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDY
|||..| ||.|.|. .|.|. ||  ||| .. .  |||.|| .|.|   ...  | |.. . ...|.  ..|...|.|||||||.||  |..||  |. .
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

MKQSpPESPILVHCSAGVGRTGTFIAIDRLIYQIENE-NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
 ...  . |...|||||||||||.||.|||. ..|.| ...||  .| .|| .| |||||  || |. . |||..  
tekk.tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1028-1301 1.8e-94 311.0 In-house 10-281 (288) alignment
Range on Protein: 1028-1301
Range on HMM: 10-281/288.0
AYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRM
|. .|..|... || |||. |  .. .. . |..||.|  ||||.|.||||  ||||   .. .. |||||.|. |...|| .|||||||..|..|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA-QDYGDITVAMTSEIVLPEWTIRDFTVKniQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDY
|.|...  |.|||. ||.|.||||||||...  . ||..|| ....  | ... | . ..  .. .   . |.....|||||||. .  |..... |   
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkva

MKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
 ..     ||.|||||||||||||||.| || ..|.|...|| |.|  ||..|.|.|||. ||.|. ...|...  
nqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

DSPc_SM00195 1041-1299 1.5e-91 301.7 In-house 2-262 (263) alignment
Range on Protein: 1041-1299
Range on HMM: 2-262/263.0
FAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
. ||.|.|.    ....  ||  .|. ||||.|.|||| .||||. . . ...|||||||. |...||..||||||||.|..||||||||..|  |.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIVLP-EWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSppESPIL
...|.|..||..|||..  . ...|.|.| .....  . |...|...... ...|.. ..|.....||||||||.|. ....   |.   ..|  ..||.
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
|||||||||||||..|| .. ..|.|..||.  ||  ||..|| ||||..|| |. ...|. .
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1041-1299 1.5e-91 301.7 In-house 2-262 (263) alignment
Range on Protein: 1041-1299
Range on HMM: 2-262/263.0
FAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
. ||.|.|.    ....  ||  .|. ||||.|.|||| .||||. . . ...|||||||. |...||..||||||||.|..||||||||..|  |.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIVLP-EWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSppESPIL
...|.|..||..|||..  . ...|.|.| .....  . |...|...... ...|.. ..|.....||||||||.|. ....   |.   ..|  ..||.
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
|||||||||||||..|| .. ..|.|..||.  ||  ||..|| ||||..|| |. ...|. .
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRA_pd Subfamily PTPRA 1014-1328 4.1e-91 300.3 In-house 7-323 (330) alignment
Range on Protein: 1014-1328
Range on HMM: 7-323/330.0
KPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQ-THSTDDYINANYMPGYHSKKDFIAT
 .||   . ||..|   ....|| |  | ||.. |    |     .|.  ||. |||. |.|||| ||| |||.  . . ||||| .. ||. |. |||.
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaa

QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVK----NIQTSESHPLRQFHFTSWPDHGV
|||. .|..|||||.||..  .|.|||.  |. ..||. |||.. .  ||.|.|..  | || ..|.|.| |.    . .  .|  .|||||||||| ||
qGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv

PDTTDLLINFRYLVRDYMKQSPPesPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRsQKDSKVD
| ..  ....   |.   .||    || ||||||||||||||..| .. ... |. |||...|  ||. || ||||. ||.|. . .|.      |...|
PfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl.ygdteld

LIYQNTTAMTIYENLAPVTT
..  ..   ..|.... .. 
vsslekhlqklynkitgtdk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1021-1307 1.3e-90 298.8 In-house 5-292 (319) alignment
Range on Protein: 1021-1307
Range on HMM: 5-292/319.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGiSQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
|.|.... ..|. .. .. ....|...||  . ..  . |.  ||. ||||.|.|.|| .||.|| ..     |||||... ||. .. |||||.|| ||
ievqeLkerlkalastgetllekefkllkeav.ndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVkNIQTSES--HPLRQFHFTSWPDHGVPDTTDLLIN
..||||||||.... ..|||| ||... |...|||... ..|| ..| . .|  | .. ||.... |...||     . .|..|.||||.||... .|..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslld

FRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK-DSKV
.   .|  ... . . || ||||||||||||||..|  . ....|...||. .|  ||. |..|||...|| |. . .|..| . . . .|
llkrirksrek.tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteiev

0045098 (Phosphotyrosine protein) phosphatases II 1035-1299 1.9e-89 295.0 In-house 3-272 (278) alignment
Range on Protein: 1035-1299
Range on HMM: 3-272/278.0
ADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKlsvqthstdDYINANYMPGYhsKKDFIATQGPLPNTLKDFWRMVWEKNVYA
|.... .  |.| | | || .  . | . .|. |||| ..|||| ||||         |||||.|..||  .| |||||||||.|. |||||.|| .. .
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNI----QTSESHPLRQFHFTSWPDHGVPDTT--DLLINFRYLVRDYMK-
|.|||..|| || ||..|||... . |||.|| ..|| ||...|.|...| |.    .. ||. ....|...|||||||...  . ....   .|...| 
ivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

----------QSPPESPILVHCSAGVGRTGTFIAIDRLIYQIenENTVDVYGIVYDLRMHRPL-MVQTEDQYVFLNQCVLDIV
          . ... |.|||||||||||||..|.. .....  |..||.. .|  ||..||  .||...||.|| ...|...
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

0040439 (Phosphotyrosine protein) phosphatases II 1057-1298 2.1e-89 294.6 In-house 3-245 (249) alignment
Range on Protein: 1057-1298
Range on HMM: 3-245/249.0
KYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS
.. |.| ||. |||| ..|||| ||||||. . .  .|||||.|..||..|..|||||||||.|..|||||.|| .. .|.|||..|| || ||..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

KQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRL
.. . |||.|| ..|..|....|.| ....|....||.  .....|.|||||||.... |..|  .||..... |...|.||||||||||||||||.. .
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
..|.| |..||.. .| .||..|| .||...||.|| ...|..
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_PTPRG_pd Subfamily PTPRG 1021-1305 1e-88 293.0 In-house 1-293 (563) alignment
Range on Protein: 1021-1305
Range on HMM: 1-293/563.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQ--PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST--DDYINANYMPGYHSKKDFIATQGPL
. |..|. .  .  ||.. ||.||.|.|.   ||.  .  ...  ||. |||| |...|| ||||||  .      |||||||. ||. .|.||||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSE------SHPLRQFHFTSWPDHGVPD
..|..|||||.||.||  |.|.|. ||.|| ||. |||. ....|| ..| ...| ||   |.| ...||..  .       .  ||.|.|.|||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

TTdlLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
 .  | .  . ...   .     ||.||||||||||||.|..| |. ||..||.|.|.|..  .|..|. .||||.||.|| . .|....|... 
hs..lpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1025-1304 2.9e-87 287.7 In-house 13-295 (298) alignment
Range on Protein: 1025-1304
Range on HMM: 13-295/298.0
NFEAYFKKQQADSNCGFAEEYEDLKLVGI---SQPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
 .. . ..... .  |.|.|.. |. |     .. | .|.  ||. |||| .....| ||| |.  ..    ||||| .. .|. .. |||||.||..|.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRY
.||||||.|... .|.|||. .|...||...|||..... ||.||| . |. .  . ..| ..|.. ...... .||.|||||||.||| ..  ..... 
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

LVRDyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
 ||  ..|   ..|..|.|||||||.||||||| .. ....|..|||. .|  ||..|| .||||.||||. . ||. . | .|
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

0042113 (Phosphotyrosine protein) phosphatases II 1060-1297 4.5e-87 286.8 In-house 4-241 (245) alignment
Range on Protein: 1060-1297
Range on HMM: 4-241/245.0
AELAENRGKNRYNNVLPYDISRVKLSVQTHST-DDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA
|.| ||. |||| ..|||| .|||||.  ..  .|||||.|..||. .. |||||||||.|..|||||.|| .. .|.|||...| || ||..|||... 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQ
. |||.|| ..|| .|...|.| ..|.|....||.  ...|...||||||||...||..|  .||..... ... |.||||||||||||||||......|
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
.| | .|... .|..||..|| .|||..||.|| ...|.
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Ptp69D_pd Subfamily Ptp69D 1021-1310 6.6e-86 283.2 In-house 4-298 (307) alignment
Range on Protein: 1021-1310
Range on HMM: 4-298/307.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| ... |  .|... |.. |.|.||| |.   |..   ..|  ||  ||||... ..|  ||||. .. . . |||||... ||. ||.||| |.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-----TSESHPLRQFHFTSWPDHGVPDTTDL
..|||||..|..|. |.||..  |. | ||. |||  . . |||| | . ||   ....||.. | ...       .|. . |.|.|.|.|  ||...  
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LINFRYLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR-SQKDSKVDLI
|... . ||.  |..  .|||.|||||||||.|.|.|.| |. |...|..||.. .| ||| .|.|.||  .||||| . .||    .. | .|| .
llklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl

Y_phosphatase Protein-tyrosine phosphatase 1065-1296 4.3e-85 280.2 Pfam-A 1-234 (235) alignment
Range on Protein: 1065-1296
Range on HMM: 1-234/235.0
NRGKNRYNNVLPYDISRVKLSVQTHSTDdYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP--SKQAQDYG
|. ||||...|||| .||||. .....| ||||||. ||..|| ||||||||..|..|||||||...| .|.|||...|.||.||..|||  ... . ||
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DITVAMT-SEI-VLPEWTIRDFTVKNIQTS-ESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMkqSPPESPILVHCSAGVGRTGTFIAIDRLIYQI
||.| .. .|     |.|.|....|. ... |.. ..|.|.|.|||||||.... |...   |. .   .. ..|..|||||||||||||.|.| |. |.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleql

ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
|.|..|||. ||  || .|| |||...||.|| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1065-1296 4.3e-85 280.2 In-house 1-234 (235) alignment
Range on Protein: 1065-1296
Range on HMM: 1-234/235.0
NRGKNRYNNVLPYDISRVKLSVQTHSTDdYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP--SKQAQDYG
|. ||||...|||| .||||. .....| ||||||. ||..|| ||||||||..|..|||||||...| .|.|||...|.||.||..|||  ... . ||
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DITVAMT-SEI-VLPEWTIRDFTVKNIQTS-ESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMkqSPPESPILVHCSAGVGRTGTFIAIDRLIYQI
||.| .. .|     |.|.|....|. ... |.. ..|.|.|.|||||||.... |...   |. .   .. ..|..|||||||||||||.|.| |. |.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleql

ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
|.|..|||. ||  || .|| |||...||.|| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1019-1305 5.3e-85 280.2 In-house 2-289 (305) alignment
Range on Protein: 1019-1305
Range on HMM: 2-289/305.0
KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVgiSQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST-DDYINANYMPGYHSKKDFIATQGPLP
| | .....|| |.....|. |. ..|. |     ...    .  .|. |||.... ..| .|..|. . .    |||||.|. ||..|| .|..||||.
kiialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQ--DYGDITVAMTSEIVLPEWTIRDFTVKN-IQTSESHPLRQFHFTSWPDHGVPDTTDL
||..||||...|  |  |.|||| ||.|. ||. ||| ....  ..|...| ..||   .....|.... .  . .||. . |...|.|||||||...  
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LINFRYLVRDYMKQSpPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
|...   |.   |..  . |.||||||||||||.|||.|  . ....|..|||....  || .|. |||| |||||| . . . . . . |
llslikrvqkdqkkd.kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdts

subfamily_PTPN9_pd Subfamily PTPN9 1023-1301 1.4e-83 275.4 In-house 3-292 (297) alignment
Range on Protein: 1023-1301
Range on HMM: 3-292/297.0
VENFEAYFKKQQadsNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLK
.|...|| |...   . |  .||....   ..   .|..|  |  ||||..|| || .||.|.  . ... ||||||.. ||. || ||||||||..| .
ieelvayvkekg...krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP--SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
||||||||..|  |.| |..||.|| || .|||  .......||..|.  .  .  ....| ...||..|.||  .  | |.||||.|||...  |....
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl

YLVRDY-----------MKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
  ||..            |  | . ||.||||||.|||||||..|  . ..|...||||   |  ||  |  ..||..||.|  ..||.   .
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_PTPN12_pd Subfamily PTPN12 1056-1304 2.5e-82 271.0 In-house 31-282 (290) alignment
Range on Protein: 1056-1304
Range on HMM: 31-282/290.0
PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST-DDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP
.. |.|  ||. |||| ..|||| |||.|| ....  .||||||.. | ..|. .||.|||||.||.|||||.|||||  ..|. . || |..||| |||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

SKQAQ--DYGDITVAMTSEIVLP-EWTIRDFTVKNIqtSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKqsPPESPILVHCSAGVGRTGTFIA
... .   .|...| ...|  .  ...|| ..|..   .||. ..|||.|.||||||| ... |...  |||.. .    ..|..|||||||||||| ||
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

IDRLIYQIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
||    ....|..   .||. .| .|| .|. .|||..||... ..|...|... .
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele

0037934 (Phosphotyrosine protein) phosphatases II 1059-1297 3.5e-81 267.6 In-house 4-240 (243) alignment
Range on Protein: 1059-1297
Range on HMM: 4-240/243.0
AAELAENRGKNRYNNVLPYDISRVKLsvqthSTDDYINANYMPGYhskKDFIATQGPLPNTLKD----FWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP
 | | ||. |||| ..|||| |||||     . .||||||.....   . .||||||||.|..|    ||||.|| .. .|.|||..|| || ||..|||
iallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

sK-QaqDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ------SPPESPILVHCSAGVGRT
   .   |||.|| ..|| .|...|.| ....|.. . ...  ...|...||||||||... |..|   ||.....       ....|.|||||||||||
.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFIAIDRLIYQIenenTVDVYGIVYDLRMHRPL-MVQTEDQYVFLNQCVLD
||.||.. .....    .||.. .| .||..||  .|||..||.|| ...| 
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPN6_pd Subfamily PTPN6 1030-1303 7.3e-81 266.5 In-house 17-301 (306) alignment
Range on Protein: 1030-1303
Range on HMM: 17-301/306.0
FKKQQADSNCGFAEEYEDLKLVGIS--QPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPG--YHSKKDFIATQGPLPNTLKDFWR
 |...  .. || ||.|.|.    .    .  .. .||. ||||.|.||.| .||.|. .  . .|||||||. .    |.| .||||| |..|..||||
ekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA-QDYGDITVAMTSEIVLPEWTIRDFTVK-NIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVR
|||..|   |.|.|| ||.|. ||  |||.... ..||.|.| ..||  | ....|...|. . . .|.. ..|.||.||||||||  .. ...|   |.
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

DYMKQSP--PESPILVHCSAGVGRTGTFIAIDRLIYQIENE---NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
  ....    . ||.||||||.||||||| || |. .||..     .|.. .|  .| .|  .||||.|| |. . .   ....|
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_PTPRK_pd Subfamily PTPRK 1022-1298 1.5e-80 265.4 In-house 5-276 (314) alignment
Range on Protein: 1022-1298
Range on HMM: 5-276/314.0
RVENFEAYFKKQQADSNCGFAEEYEDLKLVgisqpKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
||..     .. ..  . || |||| |          ||   ||| |||....|.|| |||.| . .  .  |||||... .|.  . ||.|||||..|.
rvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQdYGDITVAMTSEIVLPEWTIRDFTVKNI--QTSESHPLRQFHFTSWPDHGVPDTTDLLINF
|||||.|...|  .|.|||. ||.|| || .||| .  . |||| | . .  .| |  .| |.|...  . .| . .|||.|..||||.||     |...
kdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllkl

RYLVRdyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
   |   ..| . . .|.|||||| |||||||||| ..  ||.|..|||. .| .|| ... ||.||.||.|. . .|. 
vrrvk..ksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1021-1311 7.4e-78 256.6 In-house 6-291 (315) alignment
Range on Protein: 1021-1311
Range on HMM: 6-291/315.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKlVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| .... .|  ...| .. || ..|| .   |  .|   |   ||. |||| |...|| |||.|  .....  ||.|||...||  |. .||.|||....
ipldqlityvaqkkastkngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKqAQDYGDITVAMTSEIVLPEWTIRDFTVknIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
.|||||.|.|...  |.|||. ||. . |.|.||| |    || |||.. || |  |.|.| ..|  .  .. . . |.|.||||| |||  |  |.|. 
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswpdmgvpkytiplmnli

YLVRDYMKQSPpeSPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIY
  |. . ..|   ..|.||||||||||||||..| .. |.| || .||| ..  .|  |  |||. .|| |. . .|. .     |  . .|
rtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdly

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1060-1304 1.6e-77 255.1 In-house 4-247 (250) alignment
Range on Protein: 1060-1304
Range on HMM: 4-247/250.0
AELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTkCEEYWPSKQA
|.  .|. |||| .....| ||| |  .      ||||| .. ||. .| ||||||||..|..||||||.|... .|.|||. .|...| ...||| ..|
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQ
. |||.|| . |. .  ..|.| . . . . ...  .||.||..||| |||...   ....  |.   .|   ..|..|.|||||||.|.||||| .. .
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavler

IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
...|..|||. ..  || .|| .|....||||. . .|  . | .|
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsved

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1023-1297 1.3e-74 246.4 In-house 18-289 (319) alignment
Range on Protein: 1023-1297
Range on HMM: 18-289/319.0
VENFEAYFKKQQADSNCGFAEEYEDLKLVGISQP-KYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
... .   |..  |    .  |.  .  .|..   .  |.| .|. |||. |.|..| ..|||  ..     ||||| .. || .|. .||.||||.|||
ayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntl

KDFWRMVWEKNVYAIIMLTkcveqgRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKN-IQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
.|||||.|| |. .|..||      . || .||| |  . ..   | ..|     |...||. . .  .  .   ..||||  |||.|||| .  |. . 
adfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

YLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
  ||   ..   . .|.|||||||||||..|..| |. ....|. |||| .| |||  |. .||   || |.   .|.
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1020-1303 2.3e-74 245.0 In-house 1-282 (287) alignment
Range on Protein: 1020-1303
Range on HMM: 1-282/287.0
LIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELA-ENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPN
|| ||.|  . .|..| .| || . .  |. |. .. .   ..| .|. |||....|..|  || |       .||||| .. ||..|| ||....|. |
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfn

TLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHG-VPDTTDLLI
|...||......|| ||.||..  |. . .| .|||....  .|. ......| |  ....|.. ||| . ... . ..|...|.|...| |..    |.
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

NFRYLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
 .   ..   |..  ...|.||||..|||...|.|..  | . ..| ..||. ..   |. .| .||| .|| |.|. ||  . | .
vieemyktqrkrg..ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1021-1299 3.2e-74 244.6 In-house 3-277 (315) alignment
Range on Protein: 1021-1299
Range on HMM: 3-277/315.0
IRVENFEAYFKKQQAdsNCGFAEEYEDLKLVGISQPKYAAElAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| | .| |. .|..    . |.||. ||    |.. . | |  .|  ||||.|.||.| .||||  .. .  .||||| |...... | .||.||||. .
ipvaqfpafvnknrh..talfseefhdlpdPdiyrqrvare.tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVKNiqTSESHPLRQFHFTSWPDHGVPDTTDLLIN
..||||||....| .|.|.||  |. . ||  ||| ..|   ..| | |.. |     . ..| .....  . ||. . ||.|| |||.||.  |  |..
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllk

FRYLVRDYmkQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
.   |.    . . | ..|||||||||||| .|.||  . ||.....|||. .|  || .|| .||||..| |. . ||. .
likevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1020-1301 5.2e-74 243.7 In-house 1-285 (290) alignment
Range on Protein: 1020-1301
Range on HMM: 1-285/290.0
LIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHS---TDDYINANYMPGYHSKKDFIATQGPL
||.|..|  .  ...|  | || .... |.    ..  . .   .|. .||..|...||  |. |   .     |..|||| |. ||. ||..||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

PNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQT-SESHPLRQFHFTSWPDHG-VPDTTDL
.|||.|||...|...| .|.|||. .|.|..||  |||......|| ... ...| .| | ..| . ||| ..  ... . |...|.|...| |....  
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LINFRYLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
|. ..  ..   |.   . .|.||||..|||...|.|..  | . . |  .||. ... .|. .| .|||..|| ...| ||  . |
llvieemyktqrkrg..ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1037-1298 1.4e-73 242.8 In-house 16-275 (515) alignment
Range on Protein: 1037-1298
Range on HMM: 16-275/515.0
SNCGFAEEYEDLKLVGISqPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAI
  . |.||. ||    |  |.  |.   |  ||||.|.|||| .|||| | .     ||.|| |.|.... | .||.|||.. ...||||.|...|| .|
httlfseefhdlpgpniy.pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtti

IMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVknIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPpeS
.|.||  |. . || .||| | .    .| | | . |     . ..| .||  .. ..|. . ||||| |||.|||  |  |. .   |.    |     
amvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..h

PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
|...|||||||||| .|.||  . .... ..|||. .|  .| .|| .|||..|| |. . ||. 
pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_PTPN3_pd Subfamily PTPN3 1059-1299 1.4e-73 242.3 In-house 35-275 (280) alignment
Range on Protein: 1059-1299
Range on HMM: 35-275/280.0
AAELAENRGKNRYNNVLPYDISRVKLSvqTHSTdDYINANYM----PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP
|| ..||  |||| ..||||. ||||.    .| |||||||.    |. .  . .|||||||..| .|||.||||...  |.|||  ||.||.|| .|||
aarkpenlsknryrdilpydatrvklk..eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

SKQ-AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQspPESPILVHCSAGVGRTGTFIAID
...  ..||...| ...|    .. .|....|. .|.|.... |. ...|||||||| .. ...|   ||.. .    |.|..||||||.|||| .|...
etedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrtGvlille

RLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
  .  ||... | .  ||  .|  |  .|||..|| |. ...| . 
talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1060-1296 4.4e-73 240.7 In-house 23-265 (274) alignment
Range on Protein: 1060-1296
Range on HMM: 23-265/274.0
AELAENRGKNRYNNVLPYDISRVKLSVQTHSTD--DYINANYMPGYHSK-KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK
 ... .  ||||...|| . ||| |. .. . .  .||||||. ||. . | ..|||||||||..|||||.....|  |.||||  |. ..||..|.| .
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

QAQ----DYGDITVAMTSEIVLPEWTIRDFTVKNIQTSEShpLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPE-SPILVHCSAGVGRTGTFIA
.       |||. . ... .   ....| ...|. . . |  .  . .|.|||| .|| .. |...   |..  ...  . .|..||||||.|||| |||
edyeiserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

IDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
|.  . |...|..||| .|| .||..|  ||||..|| .. . . 
isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1059-1297 5e-73 241.1 In-house 19-253 (284) alignment
Range on Protein: 1059-1297
Range on HMM: 19-253/284.0
AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTkcveqgRTKCEEYWPSKQ
 |.| .|. |||. ..|..| ..|||  ..     ||||| .. || .|. .|||||||.|||.|||||.|| |. .|..||      . || .||| | 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

AQDYGDITVAMTSEIVLPEWTIRDFTVKN-IQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLI
 . ..   | ..|     |...||. . .  .  .   .|||||  |||.|||| .  |. .   ||   ..   ...|.|||||||||||..|..| |.
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

YQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
 ....|. |||| .| |||  |. .||   || |.   .|.
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1014-1303 3.4e-72 238.1 In-house 3-288 (297) alignment
Range on Protein: 1014-1303
Range on HMM: 3-288/297.0
KPKKSKLIRVENFEAYFKKQQadSNCGFAEEYEDLKLVGIsQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHS-TDDYINANYMPGYHSkkDFIAT
.||. . | . .| .. .|..  .   | ||. .|    | ||.  ||   |  |.||.|.|||| ||||| .  ..   ||.|| ...|..    .|.|
spkerrpiplsdfatlvqknr..htdvfseeflclpeani.qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlitt

QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPD--
| | ..|..|||.||....| .|.||..  |. . ||  ||. |  . .||..| ..|         |...|.. ..   . ..|..|..|||. |.   
qmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkd

TTDLLINFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
..  |...   ||.  .|   |.|.||||.||||||| ...||  . ....|..||..|.|  || .|| .|||..|| |. . ||. . |..
sassllklisevrkdfsqna.egPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_PTPN13_pd Subfamily PTPN13 1042-1300 9.6e-72 236.5 In-house 14-270 (273) alignment
Range on Protein: 1042-1300
Range on HMM: 14-270/273.0
AEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHstddYINANYMPGY--HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
|||...|. .   .    .. .||. |||| |||||| .||||. ..     ||||...     . . ..||.|||||.| ||||.||||...  |.|.|
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KCVEQGRTKCEEYWPSKQAQD---YGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKqspPESPIL
. .|.|. ||. |||... .    .. ..|..     | ....|...||.....||. . ...|..||||||| ... |..|   ||   .    ..||.
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
||||||.||.||.|.|| ..  ||... .||  || .||  |  .|||.|||.|  . .|....
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1060-1300 8.6e-70 229.8 In-house 15-265 (270) alignment
Range on Protein: 1060-1300
Range on HMM: 15-265/270.0
AELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHS-KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ
 | | ..  |||...||   .||.|. ... |.  ||||||..|... || .||..||||.|||.||||.||..| ||.|.|. .|.||.||| |||...
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

AQ----DYGDITVAMTSEIVLPEWTIRDFTVKniQTSESHPLRQFHFTSWPDHGVPDTTD------LLINFRYLVRDYMKQSPPESPILVHCSAGVGRTG
 .     .|.|.|. .||     . ..  ...  ...|.. |  |....||||||| ..|       |..    || . |.   ..|.||||||||||||
kekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

TFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
|.||.|  .  .|... |||  |. .|| .|. .||. .|| || . |.  ..
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPN1_pd Subfamily PTPN1 1044-1312 7.1e-67 220.1 In-house 11-285 (290) alignment
Range on Protein: 1044-1312
Range on HMM: 11-285/290.0
EYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHstdDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVE
 |.|..      |  .|.| |||..||| .| ||| ||.||  .     |||||. .   . |. .| |||||||| . ||.||||..  |..|| |.||
iyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

QGRTKCEEYWPSKQAQ-----DYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH
....|| .|||... .     .   ..| . || .  ..|.| . ..|..| |.. . .||.|.||| |||..   ...| . ||.    |.   | ..|
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRTGTFIAIDRLIYQIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR-SQKDSKVDLIYQ
||||.||.|||. .| .. .||...    ||.   . .|| .|  ..|| ||  |  . .|. ..  ..|| |. ...
csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrwk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1022-1301 1.3e-66 220.0 In-house 6-290 (325) alignment
Range on Protein: 1022-1301
Range on HMM: 6-290/325.0
RVENFEAYFKKQQADSNCGFAEEYEDLKLVGiSQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNTL
 | |.  . .|..|. . ||| |.. |  .. .. | .| . ||. |||..||...| ||| |  .   .  |||||.|.  .  |. |.|.| ||..|.
avvnlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

KDFWRMV--WEknvYAIIMLTKCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLI
.|.||.|  |.    ......  ...|  .|  ||| .  ... .| . | . .   . ..  | . ||...  |.  ..||.. ||.| ||.     ||
ndlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli

NFRYLVRDY---MKQ-SPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
..  ||      ..  .   .||||||||||||||.||..  .. .. .|  ||..| |  || .|| ||.| |||... ... . . |
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1064-1296 9e-64 209.9 In-house 2-236 (237) alignment
Range on Protein: 1064-1296
Range on HMM: 2-236/237.0
ENRGKNRYNNVLPYDISRVKLSVQThSTDDYINANYMPGYHS-KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS-KQAQDY
||. |||| |.  || ||| |     |. |||||.|. |.    | .||.|||| .. .|||.|||...   |.|||  .|. . || .|||| .| . |
enkiknrygnivaydhsrvvlkgag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDITVAMTSEIVLPEWTIRDFTVK-NIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE
| .||... .  . ..|.| ...  ...  |   . |..||||||.|||. |  |. ||  . .  .  .  .| ..|||||||||| |. || .. | .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
... ||.|  || .   || ..||.|||||..| .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_PTPN23_pd Subfamily PTPN23 1064-1303 2.5e-63 208.6 In-house 42-284 (288) alignment
Range on Protein: 1064-1303
Range on HMM: 42-284/288.0
ENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSK-KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK--QAQD
 .  |||....|||| .||||     |.|||||| .. .  .   ||||||.||..|| |||.||.|. .  |.||..  |.|..|...|||..  ... 
lyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRD--YMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ
.||..|.. |.  ....  |.....  .... . ..  ..||||..|||.. . |..|   |..  . .| . . |..|||||||||||.|  .   . .
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

IENENT-VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
.|..|  .|.  .|  ||  |  |||...|. |. . ||  .|   
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1059-1296 3.4e-62 204.8 In-house 33-274 (287) alignment
Range on Protein: 1059-1296
Range on HMM: 33-274/287.0
AAELAeNRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA
| ||| .  |||| .|||.| .|| || ...   |||||||...|. .. |||.|||.. |..||||.|.|... ..|..|. ||..| || .||| .. 
aeela.avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev

Q-DYGDIT-VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYM---KQSPPESPILVHCSAGVGRTGTFIAID
    |  . |..  .|  ||...| . . ...| |.. ..|... ||||.... |.  || |   |....   ...    |..||...|.||.|...|. 
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

RLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
 |. . |.   |||  .|  ||..|  .||.  |. .| . . 
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_CG7180_pd Subfamily CG7180 1062-1300 2.2e-61 202.1 In-house 39-291 (296) alignment
Range on Protein: 1062-1300
Range on HMM: 39-291/296.0
LAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWPSKQAQD
 .|||.|||. .|.|||  || | ... ....||||| |. ..  ||..| |..|  .|...|||.|..... |...|||  .. . .. .||| |. ..
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YGDITVAMTSEIVLPEWTIRDFTVKNI-------QTSESH---PLRQFHFTSWPD-HGVPDTTDLLINFRYLVRDYMKQS---PPESPILVHCSAGVGRT
||.| | ...|  ... .|| | ..         .. ..     ...|..| |.  . ||  |  ||..|  || ....    | |.|..|..| |..|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
| ..|||  . ..|.|. |||.. |  || .|| .|.. ..| .. . .|. | 
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1038-1299 8.9e-61 200.2 In-house 5-266 (283) alignment
Range on Protein: 1038-1299
Range on HMM: 5-266/283.0
NCGFAEEYEDLKLVGIS-QPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHstdDYINANYMP---GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVY
. ..   .| || ...  ..   |   ||. |||.....|.|  ||.|  ...   ||||| ..|    |. .|..|..|.|| .| .|||.||..... 
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

AIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESH-PLRQFHFTSWPDHGVPDTTDLLINFRYLVRDyMKQSpPE
||.||||  |. | ||  |||.. ..|||. ||..  |     ..|. .....  ...|   |  . .  | . |     . |..|  ..    ..| ..
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvisl.qtes.kk

SPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
.||.||||.|.|||..|||.   . ..  |  |||. .|  .| .|. .||| ||| .. . ||.  
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1027-1299 1.3e-60 200.1 In-house 8-280 (439) alignment
Range on Protein: 1027-1299
Range on HMM: 8-280/439.0
EAYFKKQQADSNCGFAEEYEDLKlvgISQPKYA---AELAE--NRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
. . .| . . .  | |..| ..     .|.||   . .|.  .. ||||..| ..| .|| |  .       ||||||. ||. .| .||||||  .| 
qehvekldknkqeifkeifekin...stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

KDFWRMVWEKNVYAIIMLTKCVEQGRtkceeYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNI--QTSESHPLRQFHFTSWPDHGVPDTTDLLINF
.||||.|.||..  |.|||. ||  .     ||||..   ||||.| .  .| ||...|| | | |   .|   . . |||...|||. ||  .  ...|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

RYLVRDyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD-IV
   .    ...    |..|||||||||||| ||.|  . |.  || ||. |||  || .|  |||.  ||||. ..||. ||
lrains.andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv

subfamily_PTPN14_pd Subfamily PTPN14 1043-1300 1e-59 197.0 In-house 27-297 (300) alignment
Range on Protein: 1043-1300
Range on HMM: 27-297/300.0
EEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPG--YHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK
 ||| ..        ..|.| ||  |||...||||. .||.|| . .....||||  .      .....|..||||..|..|||.||||..|. |.|||.
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte

CVEQGRTKCEEYWPSK----QAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ---S----
  |.|..|. .|.|..    .  ..|   |        .  . . ...| . ..|   .  . .| |||||||.  .  ...   |.   ..   .    
eeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

PPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
  . |.||||||||||||  |  | ||. .|.....|.  ..  ||  | |.|||  || |. . ..  ..
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_PTPRN_pd Subfamily PTPRN 1058-1299 3.3e-59 195.0 In-house 49-292 (297) alignment
Range on Protein: 1058-1299
Range on HMM: 49-292/297.0
YAAELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSK-KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS
 .|.  .|  |||...||||| |||||. .. ....|||||  .     .   .|||||||..|. |||.||||. |  |..||.  |.| ..|..||| 
evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

KQAQDYGDITVAMTSEIVL-PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQspPESPILVHCSAGVGRTGTFIAIDR
. .. |.   | . || .   .. .| | .||.||||.  . |||| |||..||| ..  |..||  |    .     .||.||||.|.||||..|.|| 
eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilidl

LIYQIEN-ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
.. .. .  . .|.   .  ||  || .|.|.||. |  ..| . |
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

0051429 (Phosphotyrosine protein) phosphatases II 1091-1311 8.1e-58 191.4 In-house 3-237 (272) alignment
Range on Protein: 1091-1311
Range on HMM: 3-237/272.0
TDDYINANYMPGYHS---KKDFIATQGPLPNTLKDFWRMvWEKNVYAIIMLTKCVEQGRTKCEEYWP------------SKQAQDYGDITVAMTSEIVLP
...||||....||..   .. .....||||.| .||||. .| .. .|..|....|.|| ||. |||            | .   ||...| ..||..|.
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

EWTIRDFTVKNI-QTSESHPLRQFHFTSWPDHGVPDTTdlLINFRYLVRDymkqsppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVD--------
 ...| ...... ...|.. ....|.|.|||||||. .  |...  |..|       . |.|||||||..||||..|...|..... |  ||        
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIY
....|  || .|| .||||.||.|| ...|...||  ..... . 
leeaveelraqrpgavqteeqylflyeallellrsllsvraeyll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1021-1298 9.1e-58 190.5 In-house 4-235 (392) alignment
Range on Protein: 1021-1298
Range on HMM: 4-235/392.0
IRVENFEAYFKKQQAdsNCGFAEEYEDLKLVGISQpKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| | .| |. .|..   .. |.||. ||    |.. . .|.   |  ||||.|.|||| .||||  ..  . .||.|| |.|.....| .||.||| . .
ipvaqfpafveknrh..salffeefhdlpgpdiyp.qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

LKDFWRMVWEKNVYAIIMLTKCVEQGrtkceeywpskqaqdygditvamtseivlpewtirdftvkniQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
|.||||||...|| .|.|.||  |                                            .  . .   ||||| |||..||  |  |..| 
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

YLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
  |.    |     |...||||||||||  |.|| .. . ..   |||. .| ..| .|| ||||..|| |.  .||. 
kevkadfGqy..thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1063-1297 3.6e-57 188.3 In-house 5-238 (239) alignment
Range on Protein: 1063-1297
Range on HMM: 5-238/239.0
AENRGKNRYNNVLPYDISRVKL---SVQTHStdDYINANYMPGYH-SKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKqA
  |. |||| |.. || ||| |   | . ||  |||||.|.  |  | | .||||| .  .  |||||.|..    |.|||  .|  . || .|||   .
rvnkaknryanivtydhsrvvleklsndphs..dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.t

QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRylvRDYMKQS-PPESPILVHCSAGVGRTGTFIAIDRLIY
  | .. |..    |. .. || | . ..  .| . . |.||| |||.|||. .  .. .|   |   |.| |   | ..||||||||||.|. || .. 
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr...rkitkdslpgarpwvihcsagvgrtgaflvidamlr

QIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
| ....|||..  |  .|  || |||| .||||.  .||.
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1060-1296 4.3e-57 188.0 In-house 3-238 (239) alignment
Range on Protein: 1060-1296
Range on HMM: 3-238/239.0
AELAENRGKNRYNNVLPYDISRVKL---SVQTHStdDYINANYMPGYH-SKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS
|.   |. |||| |.. || ||| |   | . ||  |||||.|.  |  | | .||||| .  .  |||||.|..    |.|||  .|  . || .||| 
akkrvnkaknryanivtydhsrvvleklsndphs..dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KqAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRylvRDYMKQS-PPESPILVHCSAGVGRTGTFIAIDR
  .  | .. |..    |. .. || | . ..  .| . . |.||| |||.|||. .  .. .|   |   |.| |   | ..||||||||||.|. || 
s.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr...rkitkdslpgarpwvihcsagvgrtgaflvida

LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
.. | ....|||..  |  .|  || |||| .||||.  .||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1035-1296 1.9e-56 186.0 In-house 12-290 (301) alignment
Range on Protein: 1035-1296
Range on HMM: 12-290/301.0
ADSNCgFAEEYEDLKLvGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH---STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN
. ||  |.|.|..||  | ...       ||.  ||..|. .||  |. |. ...   .. .||||.|. || .|| |||.|||. .||.||||..|.. 
khsnk.feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

VYAIIMLTKCVEQGRTKCEEYWPS--KQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS---------------ESHPLRQFHFTSWPDHGV-PDTTD
. .|.|.|.  |. ..|||.|||.  .. ...| .|| ...| |.|...||...||  ..|               .|. . |.. |.||..|| ..   
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

LLINFRYLVRdyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
 |      .    .|..  .|..||||..|.|.|......  . |   |  |||....  .|  .| .|.| .||... . . 
vLqviddvih..rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

0041856 (Phosphotyrosine protein) phosphatases II 1065-1301 1.8e-54 179.4 In-house 1-173 (182) alignment
Range on Protein: 1065-1301
Range on HMM: 1-173/182.0
NRGKNRYNNVLPYDISRvklsvqthsTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTkcveqgrtkCEEYWPskqaqdygdi
|. |||| ..|||| ||           ||||||.. |..  ..||||||||..|. ||.||..| .. .|..||         .| |||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

tvamtseivlpewtirdftvkniqTSESHPLRQFHFTSWPDHGVPDtTDLLINFRYLVRDymkqspPESPILVHCSAGVGRTGTFIAIDRLIYQienenT
                        . . .   |.....|||||||| .| |..|   |..      .. |.|||||||||||||..|.. ....      
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
|... .|  .|..|| ||.|..||.|| ...|.... 
vsleeavklvrsrRpgmvitpnqyfflqlallellll

0036282 (Phosphotyrosine protein) phosphatases II 1092-1293 2.8e-53 175.5 In-house 2-164 (174) alignment
Range on Protein: 1092-1293
Range on HMM: 2-164/174.0
DDYINANYMPGYHSKKDFIATQGPLPntlkdFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSkqaqdygditvamtseivlpewtirdftvknIQTSE
.|||||... ...  . .||.||||.     ||.|..| .. ...||....| |..||  |||.                                ....
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SHPLRQFHFTSWPDHGVPDTTDlLINFRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQIEnENTVDVYGIVYDLRMHRPLMVQTEDQYVFL
..   |.... ||||||||..  |..|  .|...... .|. |.|||||||||||||..|......... |..||.. .|. ||..|| ||||..|| ||
erlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

NQ
 .
yy

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1023-1300 1.8e-51 169.5 In-house 11-284 (290) alignment
Range on Protein: 1023-1300
Range on HMM: 11-284/290.0
VENFEAYFKKQQADSNCGFAEEYED-LKLVGISQPKYAAELAENR--GKNRYNNVLPYDISRVKLSVQthSTDDYINANYMPGYhsKKDFIATQGPLPNT
.| || .  .    .  ..| || . ||    .|.     . .|    |||| .|   |..|| |.       ||. |||. |   |  || |||.| .|
teafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdG..ydGdyvhanyvkGl..kamfiltqGalkdt

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQ--DYGDITVAMTSEIVLPEWTI-RDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLI
  |.|||| ...| ||.|| . .|.|..|||.|.| |. .   .|.|||  . |    . .| . ..|.. ..  .| |. ..  ||||. |. .|  |.
vidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

NFRYLVRDYmkqsppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
   . .|          |. ||||||.||||||.||.  .  . .   .|. ..|  ||  |   || . ||. | . .||. .
rtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

0049772 (Phosphotyrosine protein) phosphatases II 1059-1302 1.4e-49 164.8 In-house 40-283 (314) alignment
Range on Protein: 1059-1302
Range on HMM: 40-283/314.0
AAELAENRGKNRYNNVLPYDiSRVKLSVQTHSTDDYINANYMPGYhskKDFIATQGPLPNTLKDF----------WRMV--WEKNVYAIIM---------
.| | .|| |||| ..||.| .||.|. . .|. |||||.|. |.   ..||||||||..|. ||          ||||  .. ||  | |         
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTKCVEQGrtkceeywPSKQAQDYGDITvamtseivlpewtirdfTVKNIQTSESHPLRQFHFTSWPDHGVPdTTDLLINFRYLVRDY
            |... ..|        .   |.|. ..                  .. . .   ...  ... . .||...| ... .  |  .....
lsrLdaAlgKtpllildgng........neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea

mkqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIenenTVDVYGIVYDLRMHRP-----LMVQTEDQYVFLNQCVLDIVRSQ
    ....|.||||.||.||||||.... |...      |..  .. |.|. ||      .... .||.|  ...|. .. .
....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1061-1298 8.2e-49 161.2 In-house 37-276 (307) alignment
Range on Protein: 1061-1298
Range on HMM: 37-276/307.0
ELAENRGKNRYNNVLPYDISRVKLSVQTHSTdDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQD
 .  |  ||||..|   | .|. . ..  .. ||| |||.      | ||..|||| ||  .|| |. ...| ..||| |..| .. |||.||| .. | 
afsantdknryqdvkcqdkgrivvkfdglas.dyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

--YGD----ITVAM-TSEIVLPEW-TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDymKqsppESPILVHCSAGVGRTGTFIAI
  .|.    |.||   .. . |.   |   |.|   ...|  .... .. |||.|||..    ||.   ||   .    . |..|||||||||.|| .||
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..d....tnpvvvhcsaGvGrsGtivai

DRLIYQ-IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
  .  . |. .|  |.  .| .|| .|.  .||| ||..| . .|. 
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

0043147 (Phosphotyrosine protein) phosphatases II 1091-1293 1.6e-47 156.7 In-house 4-155 (172) alignment
Range on Protein: 1091-1293
Range on HMM: 4-155/172.0
TDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCveqgrtkceeywpskqaqdygditvamtseivlpewtirdftvKNIQTS
 .|||||.|...|.  ..||||||||.||| |||||..|... .|..||..                                            .. . 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

ESHPLRQFHFTSWPDHGVPdTTDLLINFRYLVRDYMkQSPPESPILVHCSAGVGRTGTFIAIDRLIyqieneNTVDVYGIVYDLRMHRPLMVQTEDQYVF
...   |.....||||||| ...||..|  ...... .  |. |.|||||||||||||..|.. ..        .... .|  .|..|| .||...|| |
lerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

LNQ
| .
lyy

0046846 (Phosphotyrosine protein) phosphatases II 1092-1296 3e-47 155.9 In-house 12-170 (176) alignment
Range on Protein: 1092-1296
Range on HMM: 12-170/176.0
DDYINANYMPGYHskkdFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYgditvamtseivlpewtirdftvkniqtse
 ||||||.. |..    .||||||||.|| ||..|..| ...|...||..|| || ||  |||  .. ..                              
ldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

shplrQFHFTSWPDHGVPDTtDLLINFRYLVRDYMKQSppeSPILVHCSAGVGRTGTFIAIDrliyQIENENTVDVYGIVYDLRMHRP-LMVQTEDQYVF
     |.... ||||||||  .||...  ..|.. |.     |.|||||||.|||||..|..     .| |. ..|. ... .|..||  .|||..|| |
.....qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

LNQCVL
| ...|
lyefel

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1036-1297 1.2e-45 150.6 In-house 3-257 (267) alignment
Range on Protein: 1036-1297
Range on HMM: 3-257/267.0
DSNCGFAEEYEDLKLVGISQPKYAAELAE-NRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA
|..| . .|.| .| .   . . .  .|| |. .||....|||| .|| |.    ....|||| |. ||. |. ||.||.|| ||  ||. .. ...|  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

IIMLTKCVEQgrtKCEEYWPSK--QAQDYGDITVAMTSEIVLPEWTIRDFTVKNiQTSESHPLRQFHFTSWPDHgVPDTTDLLINFRYLVRDYMKQSppE
|..|||  ..   .   .|| |  ||. | |.||  . |    .. |  . .|  .   .| .  ...  |    . .   |   |  | .. ...   .
ivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnin.tnnkpylkplfgilaknqleng..n

SPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
 |..|.||.||||.|||. ||  . .. .|...|..  .  .|  |. .|.| ..|... . . .
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

0049260 (Phosphotyrosine protein) phosphatases II 1099-1293 1.5e-45 150.0 In-house 1-144 (152) alignment
Range on Protein: 1099-1293
Range on HMM: 1-144/152.0
YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWpskqaqdygditvamtseivlpewtirdftvkniqtseshplrQF
...||. .. |||||||.||||.|||||..| .. .|.|||...| |. |||.|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFTSWPDHGVPDTTDLLINFRYLVRDYmkQSPPESPILVHCSAGVGRTGTFIAIDRLIyqieneNTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
... |||||||| ..||. .  ... .  .  .. |.|||||||||||||..|.. ..      . |... .|  .|..|| .|....|. || .
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1067-1299 1.1e-44 147.5 In-house 35-295 (297) alignment
Range on Protein: 1067-1299
Range on HMM: 35-295/297.0
GKNRYNNVLPYDISRVKLSvQTHSTDDYINANYM--PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK--QAQDYG
 ||||...| .| .||||  .. .  |||||.|.  |  ...  .| .|||| .|..|||..|.|..| .|.|..|  |.|| ||  ||||   . .  |
rknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

DITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP-DTTDL-------------------LIN-F---RYL-VRDYMKQSPPESPILV
|. |   |.      ..    .. |  |||  .|   | |||||||| |  ||                   |.. |    .| .  .  . | . ..||
dvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllv

HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
||||||||.|  .  | .. .. ..   ||  |.  ||  |. .||| .|. .| . ||  .
hcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_ptpA1_pd Subfamily ptpA1 1062-1252 2.2e-42 140.3 In-house 44-249 (418) alignment
Range on Protein: 1062-1252
Range on HMM: 44-249/418.0
LAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSkKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK----
   |  |||| |.|| . .||.|  .| .   |||||||. | .  |.||.||||||||. ||||||||. .  |.||..  |. | ||. ||| .    
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

QAQDYGD-------ITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPP----ESPILVHCSAGVGR
|   ||.        .| .   |  ||  |    ..     |.. . |...  |||| .|| |. . .. . . .  .|  |    . ||.|||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTFIAI
|||| . 
tgtfcta

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1040-1311 1.4e-40 134.0 In-house 23-301 (305) alignment
Range on Protein: 1040-1311
Range on HMM: 23-301/305.0
GFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
|. .|.  .| .   .   |   |...||||| .|   |  ||||  ..    .|| |||.      | || || || .|  ||| | ....| ||.|| 
glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc

KCVEQGRTKCEEYWPSKQAQD------YGDITVAMTSEIVLPEWTIRDFTVKN----IQ--TSESHPLRQFHFTSWPDHGVPDTtDLLInfrylVRDYMK
. .|.|  || ||..||. .          |.| . |   |   .  . .|..    |.   ....   ..|.  ||| ||| . || |     .    |
nllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa.dlai.....lellek

QSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVD-VYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK--DSKVDLIY
  |   || ||||||.||||. . .. .. |. . . ..    |.  .|  |   .||..||.|. | .|. .| .|  | .|. .|
arpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkeay

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1058-1299 3.5e-40 132.8 In-house 36-271 (288) alignment
Range on Protein: 1058-1299
Range on HMM: 36-271/288.0
YAAELAENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ
 . .  .|  ..||.|.   ||.|||||     .| ||.|| ..  . |. .| .| ||  |.. .|.|. |..|  |.||.. .|.|. | .||.|||.
iidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

AQD--YGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP-LRQFHFTSWPDHGVPDTtdLLINFRYLvrDYMkqSPPESPILVHCSAGVGRTGTFIAIDR
 .   .| .   .  . .  . ...  .... .. | .  ... |.  |.|.|||.    |  .| |  . .     . ||.||.|||||||||.| |  
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen..ylsplrll..evl..kslqkPivvhssaGvGrtgtlilili

LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
 . ..  .. . .  ..  || .|   .||| ||... .|||. .
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1062-1306 1e-39 130.9 In-house 49-297 (310) alignment
Range on Protein: 1062-1306
Range on HMM: 49-297/310.0
LAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQD
  ..  |||| .|.  | ||||| ..    .||| |||.   . .. || .||||  |. |||||....   .|..| | .|.|| ||  ||||   .. 
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGDITVAMTSEIVlPEWTIRDFTV----KNIQT----SESHPLR--QFHFTSWPDHGVPDTTDLLINFRYLVRdyMKqsppESPILVHCSAGVGRTGTFI
|| | |.  ||    |. | ...|     |.      .. . ||    ..  ||| ||||     .  | | .  ..      | .||||||..|... .
ygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaq..vr....hgpcvvhcsagkdrlyvvv

AIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSK
|..  | .... . ||.  .. .|. .|   .||| ||.....  . ..|....  
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargeteva

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1064-1303 3.6e-39 129.1 In-house 36-273 (281) alignment
Range on Protein: 1064-1303
Range on HMM: 36-273/281.0
ENRGKNRYNNVLPYDISRVKLSV--QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQ
 |  |||| |.   |||||.| |    . . ||| |||.     |. .| ||||  .|  |||||.|..|  ||.|| . .|  | || ||.| .   . 
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

DYGDITVAMTSEIVLPEWTIrdFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRdymKQS-PPespiLVHCSAGVGRTGTFIAIDRLIYQ
..  ..|.     |          ..     |.. . .. .  |||  ||........    .|    .| ||    ..||||||||.||..|..  .  
qfdklsvsyedstvnkslvt..trlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir...arstpp....vihcsagvgrsgtlmaveialqs

IENENTV-DVYGIVYDLRM-HRPLMVQTEDQYVFLNQCVLDIVRSQK
| .  |. |.  ||  ||.  |   ||| .||... . .||.  . |
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1065-1301 3.7e-39 129.2 In-house 55-291 (305) alignment
Range on Protein: 1065-1301
Range on HMM: 55-291/305.0
NRGKNRYNNVLPYDISRVKLSVQThsTDDYINANYMPG-YHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYG-
.  ||||..|   | | |||.  .    ||| |||.      .| ||..|||| .|. .|| || ...|  |.|| | || |. || .|||  | .    
aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

--DITVAMTSEI-VLPEWTIRDFTVKNIQT--SESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDymkqSppESPILVHCSAGVGRTGTFIAIDRLIY
   | |   |    .   .  . |. |.    ...  .|....| ||| |||      ...   .|     |  . ||.||||||.||||| .||. .. 
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....s..kvpivvhcsagigrtgtivaieyile

QI-ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
.| || .   .  .|  || .|   .|.. ||.|. . .|. .  
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle

0051082 (Phosphotyrosine protein) phosphatases II 1092-1295 4.3e-39 128.8 In-house 3-149 (151) alignment
Range on Protein: 1092-1295
Range on HMM: 3-149/151.0
DDYINANYMPGYhskkdFIATQGPLPntlkDFWRMVWEKNVYAIIMLTKCVEQGrtKCEEYWPSKQaqdygditvamtseivlpewtirdftvkniqtse
.||||..|. |.     .....|||.    ||.....| ....|..|.. .| |  .| ||.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDymkqsPPESPILVHCSAGVGRTGTFIAIDRLIYQienentVDVYGIVYDLRMHRPLMVQTEDQYVFL
 . ........|||.|.|...| ...|  |..|     ... |.|||||||.|||||..|.......      |... .. ..|..|| .||...|..|.
.ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

NQCV
 ...
lfal

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1063-1296 4.6e-37 122.5 In-house 33-267 (285) alignment
Range on Protein: 1063-1296
Range on HMM: 33-267/285.0
AENRGKNRYNNVLPYDISRVKLsvQTHStDDYINANYM--PGYhSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQ-
  |   ||| .|   . .|| |  . |   ||| |..|  ||   .  .|.||||||.|| |||.|......  ..||   .| |  ||  |.| |  . 
eanpdlnryadvrcieetrvvl..knhd.rdyihaswmrmpgk.dqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-DYG--DITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF--TSWPDHGVPDTTDLLINFRYLVRdymKQSPPESPILVHCSAGVGRTGTFIAIDR
  .|  .||..   |  .    .  .|| | . . | ||   |     |||.  |. .  .|..   |.   |  | | || |||||||||| ||. || 
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk...kvnpkekpicvhcsagvgrtatfvgidy

LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
   .| ..  ...  || ..|  |   ||.  |..||   ..
atirimenpniemldivremramrfqavqshmqflflyvvlm

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1066-1309 5e-37 122.3 In-house 51-289 (301) alignment
Range on Protein: 1066-1309
Range on HMM: 51-289/301.0
RGKNRYNNVlPYDISrVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDY--G-
. |.||..| | . |   . | .. .   | ||..|     . ||||||||.|| .||| |.   .|  |.||.. ||.  .||||| |.| ...   | 
kdkhryptv.PckPs.tavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

-DITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHGVPDTTDLLINFRylvrDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIE
 .|..  .  |.  . . | . |..     ... .  . ...|.|.||| .   | ..     . .|.|  | ||.||||||.||. .||. . |  ..|
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm....elvkks..ekPivvhcsaGiGrsvafigteylareve

NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNqcVLDIVRSQKDSKVDL
...|...   . .|| ||   |||. |  ...  .  . |  |.  .|.
adptieltealkhlrehrwngvqtnsqlywmt..lGtvyrlikeygfdm

PTPc_DSPc_SM00012 1195-1296 4.8e-35 115.3 In-house 2-104 (105) alignment
Range on Protein: 1195-1296
Range on HMM: 2-104/105.0
LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENE-NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
....|.|.|||||||...| ....   |.. ...|  ..|..|||||||||||||.|.| |. |.|.| ..||.. ||  ||..|| |||||.||.|| .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVL
..|
all

0044763 (Phosphotyrosine protein) phosphatases II 1087-1294 1.5e-34 114.5 In-house 13-166 (178) alignment
Range on Protein: 1087-1294
Range on HMM: 13-166/178.0
QTHSTDDYINANYMPGYhskkdFIATQGPLpntlKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAqdygditvamtseivlpewtirdftvkn
. . . |||||... ..     ..... |      |......| .. .|..||. .| |. || .|||..                              
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

iqtseshplRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPpeSPILVHCSAGVGRTGTFIAIDRLIYQienenTVDVYGIVYDLRMHRPlMVQTED
          |.... .||||||| .. . .|  ..........  .|.||||||||||.||..|.. ....      .... ..  .|..|| .|....
.........iqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

QYVFLNQC
|. .| ..
qlrqLyef

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1066-1304 3.6e-30 99.7 In-house 44-281 (312) alignment
Range on Protein: 1066-1304
Range on HMM: 44-281/312.0
RGKNRYNNVLPYDISRVKLSVQthsTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA-QDYGDI
.  ||| |.  .|  |  |. .    . || ||..      . |..||||| ||   ||...      .||.|.  ||.|  || .|     .  |  | 
kdlnrypniqcwdrgrftlagd...enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

TV--AMTSEIVLP-----EWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRdymKQsppESPILVHCSAGVGRTGTFIAIDRLIY
 |   . .|| .        | | . |    | .   | .. ..||||||.||. |    .   |.   |.     |.. |||||||||||.. |. .| 
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk...kd...kkpviahcsagvgrtgtlaliesmia

QIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
 .      .|  .   ||  |   |..  |||.  .|||... |.  
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl

subfamily_CG42327_pd Subfamily CG42327 1042-1226 4.4e-30 99.4 In-house 8-194 (319) alignment
Range on Protein: 1042-1226
Range on HMM: 8-194/319.0
AEEYEDLKLVgISQPKyaAELAENRGKNRYNNVLPYDISRVKLSVQ-THSTDDYINANYMPGYHS-KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
|||..||  . |..    .  .  . |.|. ||.|   .|| |  .  .  | |..|.|. ||.. .  .||.| .| ..  ||||.|||..   |. ||
aeefrdlPql.iarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

KCVEQGRTKCEEYWPSKQA----QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFtSWPDHGVPDTTDLLINFRYLVRDYM
.  |.|  .| ||.|.|..    . |||| |..    |  .. |  . .|... .|| .|  . .  |.. .||     ||     ||. .
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl

subfamily_egg_pd Subfamily egg 1063-1309 2.6e-29 96.9 In-house 38-284 (307) alignment
Range on Protein: 1063-1309
Range on HMM: 38-284/307.0
AENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQgrTKCEEYWPSKQAQDY
..|. | | . |   | ||||| ..    .||.| ||.. |     .|| .| || || .||||||....|  |.|||  .|    .|| |||  ...  
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

GDITVAMTSEIV-LPEWTIRDFTVKNIQTSESHpLRQFHFTSWpDHGVPDTTDLLINFRYLvRDYMKQSppeSPILVHCSAGVGRTGTFIAIDRLIYQIE
  .  ..  | . . . .   |.| ...   ..   . .   |    |  ..|.   .| | |   . |    |..|..  || ...|..||.  . .. 
vtvpGslrienlkvdskadplfrvtklklvGgd.deerflehw.qgdvnnssdvysplrvl.rklrnls...kpvvvqdilGvskaatlvaieiallsll

NENTV--DVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL----DIVRSQKDSKVDL
   ..   |   |  ||..|.| |..  .|.|. . ||    |.. | |.  || 
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdy

0048076 (Phosphotyrosine protein) phosphatases II 1171-1296 2.4e-28 94.0 In-house 22-140 (145) alignment
Range on Protein: 1171-1296
Range on HMM: 22-140/145.0
EIVLPEWTIRD-FTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSppeSPILVHCSAGVGRTGTFIAIDRLIYqieneNTVDVYG
   | .. |.  ... . .. ...   |.....|||||||| ..||..|  ......|.     |.|||||||||||||..|.. ...     . |... 
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll.....lgvslee

IVYDLRMHRPLMVQTEDQYVFLNQCVL
..  .|..|| .|....|. || ...|
alelvrsqrpgavpnpgqlrflyefel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1064-1171 4.5e-28 93.0 In-house 46-165 (350) alignment
Range on Protein: 1064-1171
Range on HMM: 46-165/350.0
ENRGKNRYNNVLPYDISRVKLS---------VQTHSTDDYINANYM----PGYHSKKDF--IATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTK
|   ||||.|.|||. |||||            ..||.|||||||.    .. . . ||  ||||.|||.|..||.... . .|  |..||. ||... |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CEEYWPSkqaQDYGDITVAMTSE
|..||.     .| |||| ..| 
cyrYWqe...gsydditvklask

0048179 (Phosphotyrosine protein) phosphatases II 1177-1293 4.7e-27 89.9 In-house 31-139 (144) alignment
Range on Protein: 1177-1293
Range on HMM: 31-139/144.0
WTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKqspPESPILVHCSAGVGRTGTFIAIDRLIyqienENTVDVYGIVYDLRM
.|. ..| .  .... ..  |.....|||||||| ..||..|  .......   .. |.|||||||||||||..|.....     .. .... ... .|.
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrs

HRPLMVQTEDQYVFLNQ
.|| .|....|. || .
rrpgavpnpgqlrfLle

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1105-1293 3.1e-23 77.0 In-house 3-198 (199) alignment
Range on Protein: 1105-1293
Range on HMM: 3-198/199.0
SKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSE--SHPLRQFHF
... .|||| || .|. |||.||||     |.|.     .  .    |||. ..    || ..|.  .  . |..||  . . |  |.   .  . .. |
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPDTTdLLINFRYLVRDYMKQSPP--ESPILVHCSAGVGRTGTFIAIDRLIYQIENENT--VDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
||| ..  |. . |.. |    |.  |.     ..|..|||| | | || |.|.|  .   |. .|  ||.. .   ||  |  .. . ..| |. |
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1106-1293 4.1e-23 76.6 In-house 3-197 (198) alignment
Range on Protein: 1106-1293
Range on HMM: 3-197/198.0
KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSE--SHPLRQFHFT
.. .|||| || .|| |||.||||     |.|.     .  .    |||. ..    || ..|.  .  . |..||  . . |  |.   .  . .. ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDTTdLLINFRYLVRDYMKQSPP--ESPILVHCSAGVGRTGTFIAIDRLIYQIENENT--VDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
|| ..  |. . |.. |    |.  |.     ..|..|||| | | || |.|.|  .   |. .|  ||.. .   ||  |  .. . ..| |. |
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1100-1297 2.6e-22 73.7 In-house 83-286 (302) alignment
Range on Protein: 1100-1297
Range on HMM: 83-286/302.0
MPGYHSKKDFI-ATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTS-EIVLPEWTI-RDFTVKNIQT-----
| |   |..       |  .||. .| .. . ||  .. |.. ||..  || ||.  |      .|  ||   | .  | |.|  ..|.. ...      
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

--SESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQsppespILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQ
     ...  ..|..||||| |. ..  ..       | |.      .|||||||||||||..||   |    .... |.  ||  .|  |   ||.|.|
kkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

YVFLNQCVLD
 ..|  ||  
liylllcvtk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1187-1299 2.1e-21 70.8 In-house 83-194 (440) alignment
Range on Protein: 1187-1299
Range on HMM: 83-194/440.0
IQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSpPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTED
|.  ||. |.|.|. .|||.|||  .  ....   | .  ...  ..|.|||||||.||||  ||.| .. . .  . .|.. ..  .|  || |||| .
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYVFLNQCVLDIV
||.|....||. .
qyafvheavlegl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1060-1298 1.3e-20 68.1 In-house 46-284 (302) alignment
Range on Protein: 1060-1298
Range on HMM: 46-284/302.0
AELAENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPNTL---KDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWP--
    .|  ||. ..|  .|  .|||.   .. |.|.||  .   . ..  | .| |  ..     .|||||.....  . .| .  |  .   .|..|  
kafkknlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

SKQAQDYGDITVAMTSeI-VLPEWTiRDFTVKNI--QTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVrdYMKQSPPESPILVHCSAGVGRTGTFIA
| . ..||.. |     .    | .   ...  .    |.|      ..| |... ||.    ||.    |  ..|... ......    |.|| |.|..
sgdykeygkmfvNnrk.Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagaflt

IDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
    . ...... . .  ||  .|  || .|.. .|||.|  ..|  
lavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1068-1299 2.6e-19 64.4 In-house 22-257 (290) alignment
Range on Protein: 1068-1299
Range on HMM: 22-257/290.0
KNRYNNVLPYDiSRVKLSV-QTHSTDDYINANYMPgYHSKKDFIATQGPLPNT-------LKDFWRMVWEKNVYAIIMLTKCVEQGRT----KCEEYWPS
..|... |  . .|| | .  .. .|||| ||..  . .   .|.|| |. ..       ...|| |. . .|  ..|| .  |. .      |..| | 
dqRlevpLvea.trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

KQA--QDYGDITVAMTSEIVLPEWTIRDFTVKnIQTSESHPLRQFHFTSWPDHGVPDTTDLLINfryLVrDYMKQSppESPILVHCSAGVGRTGTFIAID
.      ....||  .| .   .  .|  .||  .  | . .    . .| .  |...| .|..   |. ...|.|  ..|..|||  |. |  .. ||.
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktlls...li.qkvkas..ktpvivHcvdGiSrsAalaaii

rLIYQI--ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLdiV
 | ||   | .. | .  ....|| .| |..... .. |    ..  .
.lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..l

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1113-1305 4.5e-19 63.5 In-house 39-229 (255) alignment
Range on Protein: 1113-1305
Range on HMM: 39-229/255.0
QgplpnTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPD
      |.. |....  ..   ..||.   |.|. ||..|.| ..   . . |..|. |  .  .    .. | .  .  . | .. .... |...  |.
l.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

TTDLLINFRYLVRDymkqSppeSPILVHCSAGVGRTGTFIAIDrLIYQ-----IENENTVDV--YGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV--RS
 .  . |   .|||    |    ...||||.|.||. .|. .. |.||     ... .||..    .. .|| .|.  ..|  |  |    |||.|  ..
lareilnilkvvrd....s...ksvvvhCstGiGrsaafvlae.lvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg

QKDS
. . 
elea

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1055-1292 6.1e-19 62.7 In-house 36-272 (303) alignment
Range on Protein: 1055-1292
Range on HMM: 36-272/303.0
QPKYA-AELAENRGKNRYNNVLPYDISRVKLSvqthsTDDYINANYMPgYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYW
 |. .  .. .|  |||. .|.  | |.||||        || |.|.   .|.|  | || ||. |  |||.|. |..|  ...|    |  .   .  .
ppsvsknqfvknmdknrfvdvicldhskvkls.....dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

PSKQA-QDYGD--ITVAMTSEIV-LPEWTIRDFTVKNIQTSesHPLRQFHFTSWPDHGVPDT-TDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT
| .|   .. .  | |    ..     |...  .| | .      |   |. .||   .|   .  ...  . .. ....  . .| .    .|.||.||
prnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyk..sflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragt

FIAIDRLIYQIENEN-TVDVYGIVYDLRMHRPLMVQTEDQYVFLN
|  ..     . .|. ..|.   .  .|  |   ||   |. .. 
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1064-1168 1.1e-18 61.7 In-house 47-165 (349) alignment
Range on Protein: 1064-1168
Range on HMM: 47-165/349.0
ENRGKNRYNNVLPYDISRVKLSV-------QTHS--------TDDYINANYM--PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGR
|   ||||...|||. |||||           .|         ||||||||.  . .  .| .|||| ||| |..||....  ..|  .. |..  |.. 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

TKCEEYWpskQAQDYGDITVAM
 ||. ||   |  .| .||| .
ekcdiyw...qelsysnitvkl

subfamily_eak_pd Subfamily eak 1064-1216 1.4e-16 54.8 In-house 51-202 (332) alignment
Range on Protein: 1064-1216
Range on HMM: 51-202/332.0
ENRGKNrYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQDY
|.  .|   ...|||   |.|.      . ||||  .   .  . .| |  .  . .  ||.|| |..  ||..| . ||..  | . |.| |     ..
eavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

GDITVAMTSEIVLPEWTIRDFTVKniQTSESHPLRQFHFTSWPDHGVPDTTDLLI
| . |   . .       | . ..  .  |.| .  ...  | .  .|   |.| 
Gildverkefvkrniletrllels..kGnethrvlhykvfGwtettlpkyedfla

subfamily_hpo-7_pd Subfamily hpo-7 1116-1302 3.8e-16 53.8 In-house 43-230 (263) alignment
Range on Protein: 1116-1302
Range on HMM: 43-230/263.0
LPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTD
| .|.. |....  ..   ..||.   |.|. ||..|.| ..   | . ...|. |  .  .    ....    .  . | .... .. |...  |  . 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

LLINFRYLVRDYmKqsppesPILVHCSAGVGRTGTFIAIDrLIYQ-----IENENTVDV--YGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQ
  .|   ..|.  |      .. ||||.|.||.  |  .. |.||     ... .||..    .. .|| .|.  ..|  |  |    |||.|  .
eilnilkvarns.k......slvvhcstGiGrsaafsvaE.lvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1191-1304 2.4e-15 51.1 In-house 213-349 (350) alignment
Range on Protein: 1191-1304
Range on HMM: 213-349/350.0
ESHPLRQFHFTSWPDHGVP-DTTDLLINFR--------YLVRDYMkQSPPESPILVHCSAGVGRTGTFIAIDRLIY------QIENE-N-------TVD-
. . . |...  |.| ..  .  ..|  .            . .. ..   ||||||||||||||||....| |.       ....| .       | | 
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshl.dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

VYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
.  ||  ||  |  |||. ||..|. ...|   . .||
isiivnelrkqrismvqnldqfifiYeallfyfaLrkd

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1067-1208 3.3e-15 50.4 In-house 98-235 (244) alignment
Range on Protein: 1067-1208
Range on HMM: 98-235/244.0
GKNRYNNVLPYDISRVKLSVQThSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKcVEQGrtkcEEYWPSKQAQDY--GDI
 |||    ||.|..|| ||  .   . |||| ..       ..| || || .|  |||.|. |. |  ...|   ||.     .||||  .  ..   ||
wknregaglpfdfnrvplskgs.mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeedi

TVAMTSEIVLPEWTIRDFTVKNiQTSESH-PLRQFHFTSWPDHGV
||..|    . .    .. ..  .  |||  |  |  . ||  | 
tvtltdrdefknikasnleies.dmneshqaltmfqisnwpsdgt

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1236-1297 5.5e-15 49.5 In-house 2-63 (69) alignment
Range on Protein: 1236-1297
Range on HMM: 2-63/69.0
LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
.||||.| |||||||||   . .|  |  ||..  |  .|  ||.||  | .|.|.   . .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1237-1297 1e-14 48.6 In-house 2-62 (69) alignment
Range on Protein: 1237-1297
Range on HMM: 2-62/69.0
VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
||||.| |||||||||   . .|  |  ||..  |  .|  ||.||  |..|.|. . . .
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve

subfamily_CG42327_pd Subfamily CG42327 1232-1294 1.6e-14 48.3 In-house 247-310 (319) alignment
Range on Protein: 1232-1294
Range on HMM: 247-310/319.0
ESPILVHCSAGVGRTGTFIAIDRLIYQIENE-NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQC
  |. |||| ||||||. || |  | ..|.  ..||.  .|. .|  |   |.| .|| |. . 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1044-1140 6.9e-13 42.8 In-house 15-118 (347) alignment
Range on Protein: 1044-1140
Range on HMM: 15-118/347.0
EYEDLKLVGISQPKYA-AELAENRGKNRYNNVLPYDISRVKLSV------QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAII
 | | .| . | .|.. .|   .  ||| ..|   | .|| ||       ..  .. |||| ..    ..|..| || |||.|..|||.||   .|  ..
tyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

MLTK
 . .
tife

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1019-1114 7.5e-12 39.3 In-house 3-95 (95) alignment
Range on Protein: 1019-1114
Range on HMM: 3-95/95.0
KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVgiSQPKYAAELA-ENRGKNRYNNVLPYDISRVKLSvqTHSTDDYINANYMPGYHSKKDFIATQG
| | |  | ..  . ...|.  | .|.  . .   |   |..  .  |  |||. |..||| .|| |.  |.   ||||| .. ||  |. .||.||
kpihvsvfhshvlemhsnsdqefdnefksismt..sgapytvgsseanipknrflnifpydatrvvlt..tkrdsdyinacfvdgyarkncyiaaqg

0038934 (Phosphotyrosine protein) phosphatases II 1198-1291 8.9e-12 40.5 In-house 82-169 (194) alignment
Range on Protein: 1198-1291
Range on HMM: 82-169/194.0
FHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIAIdrliYQIENENTvDVYGIVYDLRMHRPLMVQTEDQYVFL
..   .||.|.. ....| .|  || ......| .  ..||| ||.|||||..|     | |.  .  ..   .. .|. || .... |..  |
ylklpfpddgtvPsleillrfldlvdeflnedp.ggvvaVHCkaGlgRtGtlvaa....YLiyrlgm.saeeAialfrekRpgaipnqdyleal

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1075-1207 1.2e-11 39.0 In-house 3-125 (130) alignment
Range on Protein: 1075-1207
Range on HMM: 3-125/130.0
LPYDISRVKlsvqthsTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKcVEQGrtkcEEYWPSKQAQD--YGDITVAMTSEI
|....||..        ..||||...      .... || || .|  |||.|. |. |  ...|   ||.     .||||  .  .    ||.|..|   
lefevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdrd

VLPEWTIRDFTVKNiQTSESH-PLRQFHFTSWPDHG
   .     . ... .  |||  |  |. . ||  |
efknikasnleies.dlneshqaltmfqisnwpsdg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1021-1106 1.6e-10 34.9 In-house 6-89 (440) alignment
Range on Protein: 1021-1106
Range on HMM: 6-89/440.0
IRVENFEAYFKKQQadSNCGFAEEYEdLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSK
| | .|  | ....      | .|.  |   |.|||   | | .|. |||| |.| || ||| |  |.    .||||| |. | .|.
iivadfadyvqnnr..rsrafedews.llpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1102-1167 2.8e-10 34.1 In-house 231-294 (440) alignment
Range on Protein: 1102-1167
Range on HMM: 231-294/440.0
GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQgrtKCEEYWPSK-QAQDYGDITVA
||  |. ||||| ||  |. ||||.| . .. .|||| .  ..    |  ||| . ..  .| .|| 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1228-1303 2.5e-09 31.0 In-house 261-348 (349) alignment
Range on Protein: 1228-1303
Range on HMM: 261-348/349.0
QSPPESPILVHCSAGVGRTGTFIAIDRLIY----QIENENTVDVY--------GIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
..   |..||||||| ||||... .| |.       .. | ...          ||  ||  |  |||   |.... ...|  .. .|
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkk

PTEN_1 1197-1251 3.6e-09 31.7 In-house 96-149 (196) alignment
Range on Protein: 1197-1251
Range on HMM: 96-149/196.0
QFHFTSWPDHGVPDTtDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIA
...  ...|||.|.  . |. . . . ..... |..  .|||| ||.||.|| .|
eylhfpieDhgapsl.selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1055-1145 3.8e-09 30.5 In-house 24-114 (332) alignment
Range on Protein: 1055-1145
Range on HMM: 24-114/332.0
QPKYAAELAENRGKNRYNNVLPYDISRVKLSVQThSTDDYINANYMPGYHSKKDFIATQGPLPN-TLKDFWRMVWEKNVYAIIMLTKCVEQG
 |.   .. .|   ||   .  .| |||.|. |    ||. ||... ||  |  .| .| |. . |   ||||| |..   |...    |. 
ypntydkflnnmdmnriphlycfdhsrvelapqd.gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq

subfamily_eak_pd Subfamily eak 1218-1305 2.6e-08 27.6 In-house 223-311 (332) alignment
Range on Protein: 1218-1305
Range on HMM: 223-311/332.0
FRYLVRDYMKQSPPESPIlVHCSAGVGRTGTFIAIDRLIYQIENE--NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
.. ... |..  |  .|| . .. |  |.|.|. || ||  |.|   |.  |  ..   . .|   | .. |. |. . ||| .. ... 
lsstlkkyihtppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr

fn3 Fibronectin type III domain 369-437 3.8e-08 26.5 Pfam-A 3-76 (85) alignment
Range on Protein: 369-437
Range on HMM: 3-76/85.0
VFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVA--GETD-SSNLNVSEPR--AVIPGLRSSTFYNITVCPV
. .... ....||||| |. ... ..    |.....  |... . . .|...   ....||. .| |...|  |
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav

fn3 Fibronectin type III domain 120-187 5.7e-08 26.0 Pfam-A 1-74 (85) alignment
Range on Protein: 120-187
Range on HMM: 1-74/85.0
SPVFDIKAVSISPTNVILTWKSN---DTAASEYKYVVKHKMEN--EKTITVVHQP-WCNITGLRPATSYVFSIT
|.. .... ....|.. |.|.     .   . |.  ...| ..  .|..||  .   ...|||.| |.|.|...
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1059-1103 9.2e-08 26.0 In-house 33-77 (244) alignment
Range on Protein: 1059-1103
Range on HMM: 33-77/244.0
AAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGY
 | |. |  |||| |.||.| .|| ||   .   |||||||. | 
navlsanatknryinilpfdetrvilssskkegsdyinanyiqgs

subfamily_PTPDC1_pd Subfamily PTPDC1 1198-1294 9.2e-08 26.7 In-house 85-171 (182) alignment
Range on Protein: 1198-1294
Range on HMM: 85-171/182.0
FHFTSWPDHGVPDTTDLLInfryLVRdYMKQSPPESPILVHCSAGVGRTGTFIAIdRLIYQieneNTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQC
..  .|.|.||.  . .|     .|.  ....  |  . ||| || ||||  ||   |.|.    . ..    .  .| .||  .|| .|  .... 
vynfgwkDygvasleriLd....ivk.vvafalqegkvavhChaGlGrtGvliac.ylvya....krltaekaiklvrskrpksiqtreqvelvkef

fn3 Fibronectin type III domain 626-704 1e-07 25.2 Pfam-A 3-80 (85) alignment
Range on Protein: 626-704
Range on HMM: 3-80/85.0
PSNVSNIDVstNTTAATLSWQNF-DDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDG
|.|.| ..|  ..| .||||.   |. .|  .| .  ...|...  ... ..   | .|.|.| ||..|.... |. |.|
Penlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag

fn3 Fibronectin type III domain 541-606 1.9e-07 24.3 Pfam-A 1-73 (85) alignment
Range on Protein: 541-606
Range on HMM: 1-73/85.0
SAVFDIHVVYVTTTEMWLDWKSP-DGASEYVYHLV-IESK-HGS--NHTSTYDKA--ITLQGLIPGTLYNITI
||. ...|  ||.|.. | |. | || .....  |  ..| .|.  .. ..   .   ||.|| ||| |....
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrV

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1052-1161 2.3e-07 23.9 In-house 14-90 (169) alignment
Range on Protein: 1052-1161
Range on HMM: 14-90/169.0
GISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAnympgyhskkdfiatqgplpntlkdfwRMVWEKNVYAIIMLTKCVEQgrtkcE
 |   .. |||. |  |||    |     ||||  |  .   |||||                           ||.|| |   |..|  . ..     .
tieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....n

EYWPSKQaqDY
..|| |.  ||
nfwpeke..dy

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1052-1161 3.4e-07 23.2 In-house 13-89 (169) alignment
Range on Protein: 1052-1161
Range on HMM: 13-89/169.0
GISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAnympgyhskkdfiatqgplpntlkdfwRMVWEKNVYAIIMLTKCVEQgrtkcE
 |   .. |||. |  |||    |     ||||  |  .   |||||                           ||.|| |   |..|  . ..     .
tieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....n

EYWPSKQaqDY
..|| |.  ||
nfwpeke..dy

0048567 (Phosphotyrosine protein) phosphatases II 1198-1258 4.2e-07 24.5 In-house 40-103 (157) alignment
Range on Protein: 1198-1258
Range on HMM: 40-103/157.0
FHFTSWPDHGvPDTTDLLINFRYLVRDYMKQSP-PESPILVHCSAGV---GRTGTFIAIDRLIYQ
.... . |.| | . ..|..| ... ...|.    . .| |||.||    |||.|.|.   ....
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl

subfamily_PTEN_pd Subfamily PTEN 1200-1276 2.7e-06 22.5 In-house 84-157 (184) alignment
Range on Protein: 1200-1276
Range on HMM: 84-157/184.0
FTSWPDHGVPdTTDLLINFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIAIdRLIYQIENENTVDVYGIVYDLRM
 .   ||  | . .|| ..   ......... .  . ||| || ||||. |.   |...   |.. ..  .    |.
vypfdDhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRt

subfamily_VSP_pd Subfamily VSP 1204-1251 5.5e-06 20.5 In-house 102-147 (212) alignment
Range on Protein: 1204-1251
Range on HMM: 102-147/212.0
PDHGVPDTTDLLiNFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIA
 || ||   .|| .|   |...... . .  . .||  | ||||| . 
ddhnvpkleell.vftkevkewlekdl.knvlaihckGGkgrtGtivc