Gene PTPRO in Homo sapiens

Synonym: GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, PTPRO

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP093_AA protein Get Run
HsapP093_AA_920-1197 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 914-1202 1.2e-134 443.0 In-house 3-291 (293) alignment 
Range on Protein: 914-1202
Range on HMM: 3-291/293.0
LTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGP
 ..|..|..|....|.|..|||..|| ..||||..| |  . ||.|. ||.||||||||||| |||.| ....|.|.||||||||||||||.|.||||||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPtaNAAES
||||..|||.||...||.|||||||. ||..|||..||| .|||..||||.|....|||..||..|...|. ..|...|.....|.|||||||  .....
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvP..ektkt

ILQFVHMVRQQA--TKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQ
.|.||..||...  |.||.|...||||||||||||||||||||.|.....|||.|.|.|.|. |...||||.|||||||||. ...||...
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeee
subfamily_PTPRD_pd Subfamily PTPRD 916-1193 2.2e-110 364.9 In-house 3-278 (564) alignment 
Range on Protein: 916-1193
Range on HMM: 3-278/564.0
NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIgLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP
.|.. ... .... . ..||.||. ......      .  ||. | |. |||| ||..|| |||.| ... .|| |||||..| ||.....||||||||.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEePIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTANaaES
|| .|||.|| .|.|..|||||...|| .|||..||| .. .  ||..||.. .|||  |  .|.|...    .|.. | .|..|.|||||||.    .|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa..ts

ILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
.|.... ||. ... .||...|||||||||||||..| .|. |.. . ||| . |...|. |  ||||||||||||. ..
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
0051299 (Phosphotyrosine protein) phosphatases II 917-1194 4.7e-100 330.0 In-house 4-284 (288) alignment 
Range on Protein: 917-1194
Range on HMM: 4-284/288.0
PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPE
.......  ... . ... ...  .||||  .  |..  || || |. ||||..||||| |||.| .....|| |||||.||.|||.....||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFtEEPIAYGDITVEMISEEEQDDWACRHFRIN------YADEMQDVMHFNYTAWPDHGVPTanA
| .|||.|| .|....|||||.. |. |.||..|||  .... ||||||...|||..||. .|....       . .| . |.|| ||.|||||||.   
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd..s

AESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
.|..|.|...||..  ...||...|||||||||||||||| ||.... .. ||.|..|  .|..|. ||||.|||.|.....  
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 923-1200 2.6e-97 321.1 In-house 24-303 (308) alignment 
Range on Protein: 923-1200
Range on HMM: 24-303/308.0
FDAYIKDMA-----KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLvsmneEEGADYINANYIPGY--NSPQEYIATQGPLP
.. ...|..     ... .... .||||  .  ... ..| || |. ||||..||||| |||.|     .|| |||||.|..||  ..|...||||||||
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlp

ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT--EEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTAnaA
.| .|||.|| .|....|||||.. |. |.||..||| .  .... ||..||...|||..||. .|.... .   .|.  |.|| ||.|||||||.   .
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps..p

ESILQFVHMVRQQAtkSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
|..|.|...||..   ..||...|||||||||||||||| ||.... .  ||....|  .|..|. ||||.|||.|...... ....|.
eilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 918-1193 1.3e-96 318.4 In-house 2-277 (318) alignment 
Range on Protein: 918-1193
Range on HMM: 2-277/318.0
VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPET
....|..  .. . .. . ..| ..|.|.     . .. .  | |. ||||.|||.|| .||.|  ...|||.||||||||.||.. ..|||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

RNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPfTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPTANaaESIL
 .|||.|| .|.|..||||||..|. ..|...|||  .....||...||. .| | .|.  |.|...    .| ..|  ..||.|||.|||.     |.|
ieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..asll

QFVHMVRQQA-TKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
..|  |..   ....||...||||||||||.|||.| ||..|.. . ||... |...|. |  |||||.||.||.. ..
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll
0040438 (Phosphotyrosine protein) phosphatases II 922-1206 2.5e-96 317.9 In-house 4-286 (317) alignment 
Range on Protein: 922-1206
Range on HMM: 4-286/317.0
DFDAYIKDMAKDSDYKFSLQFEELKLIGLDiPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDF
|.. ...|. | . .... .||.|  . || .   | || |. ||||..|||||.|||.| .... .. |||||.|..|.| ....||||||||.| .||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFtEEPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTanAAESILQFVH
|.|| .|....|||||.. |. |.||..|||  .|.. |||.||...|||| ...  |....   . .|   |.|| ||.|||||||     ...|.|..
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spdllldfle

MVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCIS
.||..  ...||...||||||||||||||....|.... ...||.   | |.|..|. .|||.|||.|...... ....| .  ..|
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepas
0036941 (Phosphotyrosine protein) phosphatases II 930-1208 5.3e-94 310.1 In-house 7-289 (297) alignment 
Range on Protein: 930-1208
Range on HMM: 7-289/297.0
MAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLvsmnEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK
. ... .... .||||  . |...  .| || |..||||..|||||..||.|    ..|| |||||.|..||. ....||||||||.| .|||.||..|.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SQIIVMLTQCNEKRRVKCDHYWPFT-EEPIAYGDITVEMISEEE--QDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTanAAESILQFVHMVRQ-
...|||||.. |. |.||..||| . .|.. |||.||...|.|.   ||.  |.... .   .|   |.|| || |||||||.   ..|.|.|...||. 
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkv

-QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIR---DHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDV
 ... |.||...||||||||.|||||.| .|| ..    .. |||| .| ..|..|. .|||.|||.|......  ..||.. ......
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
0046845 (Phosphotyrosine protein) phosphatases II 938-1200 7.1e-94 309.6 In-house 2-278 (284) alignment 
Range on Protein: 938-1200
Range on HMM: 2-278/284.0
FSLQFEELKLIGLDI--PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEE-EGADYINANYIPGY-----NSPQEYIATQGPLPETRNDFWKMVLQQK
.  .||||  .  ..  .  .| || |. ||||..||||| |||.| |.... |. |||||.|..||     ......||||||||.| .|||.||..|.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY---ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQAT
...|||||.. |. |.||..||| ..|.. |||.||...|||..||. .|.... .    .|   |.|| ||.|||||||.   .|..|.|...||.. .
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrelle

--KSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE---FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
  ...||...|||||||||||||||| ||.... ..    ||.|..|. .|..|. ||||.|||.|...... ....|.
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0043336 (Phosphotyrosine protein) phosphatases II 918-1193 6e-93 306.6 In-house 2-274 (278) alignment 
Range on Protein: 918-1193
Range on HMM: 2-274/278.0
VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLdIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPET
..  |.  ..... ... ....|.||||  . | ..   | || |. ||||..|||||.|||.| ....... |||||.|..||| |...||||||||||
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

RNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPftEEPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTanAAESIL
 .|||.|| ......|||||.. |. ||||..|||  .... |||.||....||..||.  |....   . .| . |.|. |..|||||||.    ...|
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slslll

QFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
.|...||..  .|.||...|||||||||||||||..||...... .||..  |.|.|..|...|||..||.|......
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 917-1200 7.9e-93 306.4 In-house 13-293 (297) alignment 
Range on Protein: 917-1200
Range on HMM: 13-293/297.0
PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDipHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEE-EGADYINANYIPGYNS-PQEYIATQGPL
|..|. .|.... . ..| ... |.||||. .  |     | || |. ||||..|||||.|||.| ....  .. |||||.|..||.  ....|||||||
piplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

PETRNDFWKMVLQQKSQIIVMLTQCNEKRRvKCDHYWPFTEEpiAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVP-TANAAES
||| .|||.|| .|....|||||...|. | ||..||| ...   |||.||.....|. |..  |.... . .|   |.|| || ||||||| ...   .
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellle

ILQFVHMVRQQAtKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
.|..|. ..... ...||...||||||||||||||....|.... .  ||.|  |.|.|..|. .|||..||.|...... ....|.
flelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 925-1196 3.3e-92 303.6 In-house 10-279 (288) alignment 
Range on Protein: 925-1196
Range on HMM: 10-279/288.0
AYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKM
|... . ...   || ... |  .. .  . |. |. |  |||| ||||||. ||.|  ..||.|||||||.|| |... ..||||||||..| ||||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQ
| ..|.. |||||.  |. . ||..||| ...|  ||..||......|..|.  |.. ..   .  .. ...|.|||||||| .  .. .|.....| ..
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPes..kapllellrqvkva

ATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMW
 ..  ||.|.|||||||||||||||| |..... ....|..| |...|  |...|||..||.||....  . 
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0047943 (Phosphotyrosine protein) phosphatases II 933-1193 5.5e-91 300.1 In-house 9-269 (273) alignment 
Range on Protein: 933-1193
Range on HMM: 9-269/273.0
DSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLvsmnEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQI
.. ... ..||.|. .  ...  .| || |. ||||..||||| |||.|    ...| |||||.|..|||.....||||||||.| .|||.|| .|....
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLTQCNEKRRVKCDHYWPFTEE--PIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTanAAESILQFVHMVRQQATK-
|||||.. |. |.||..||| ...  .. ||..||...|||. ||.  |.... .   .|   |.|| || |||||||.    ||.|.|...||..  . 
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp..slesllefielvrkaleal

-SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
 |.||...|||||||||||||||| ||.... .  ||.| .|  .||.|. ||||.|||.|..... 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 917-1198 2.4e-90 298.7 In-house 8-306 (307) alignment 
Range on Protein: 917-1198
Range on HMM: 8-306/307.0
PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGL--DIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEE-EGADYINANYI--------PGYNSPQ
.... ... ... . .|. ...  .||.|. .     ... .| || |. ||||..||||| .||.| |.... |. |||||.|.        .||....
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

EYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN---YADEMQDVMHFNYTAWPD
..|||||||||| .|||.|. .|....|||||.. |. |.||..||| ..|.. ||..||...|||..|.. .|....    . .|   |.|| ||.|||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

HGVPTanAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEF---VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWM
||||.    |..|.|...||.  ......||...||||||||||||||.. .|.......    ||.|  |...|. |. .||..|||.|......  ..
hgvpp..sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

K
|
k
DSPc_SM00195 953-1193 3.8e-89 293.9 In-house 17-259 (263) alignment 
Range on Protein: 953-1193
Range on HMM: 17-259/263.0
PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP
.   |. . |. ||||.|||||| .||.| . ...|| |||||||| |.|....|||||||||.| .|||.||...|..||||||...|. . |||.|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

FT-EEPIAYGDITVEMISEEEQD-DWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPtaNAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA
 . ...  .|.|.|.....|... ..  |...... .  | ..| ...|..|||||||  . ..|.|.....|...  .|.||...||||||||||||..
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
.| .|....... |||  .|.|.|. |..||||.|||.||.... 
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 953-1193 3.8e-89 293.9 In-house 17-259 (263) alignment 
Range on Protein: 953-1193
Range on HMM: 17-259/263.0
PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP
.   |. . |. ||||.|||||| .||.| . ...|| |||||||| |.|....|||||||||.| .|||.||...|..||||||...|. . |||.|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

FT-EEPIAYGDITVEMISEEEQD-DWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPtaNAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA
 . ...  .|.|.|.....|... ..  |...... .  | ..| ...|..|||||||  . ..|.|.....|...  .|.||...||||||||||||..
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
.| .|....... |||  .|.|.|. |..||||.|||.||.... 
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 926-1195 1e-88 292.1 In-house 5-275 (281) alignment 
Range on Protein: 926-1195
Range on HMM: 5-275/281.0
YIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMV
 .|.. ....  |  ..|.|. ||.| .  |.  . |. ||||.||  || .||..   .|.. .||||||..|||....||||||||.|.. ..||.||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

LQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI-NYADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVR-Q
..|| ..|||.|.  |. ..|| .|||  .. . |||.||....|||.  ...|.|.. .   | ..| ...||||||||||.   .. .|.| . |.  
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPat..tkellefrkevlkl

QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHI-RDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLM
. .|.| |..||||||||||||.||||||.... ...| .|.  .| |.|  |. ||||  || |... |  .
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_PTPRG_pd Subfamily PTPRG 918-1202 2.3e-87 288.5 In-house 1-293 (563) alignment 
Range on Protein: 918-1202
Range on HMM: 1-293/563.0
VQLDDFDAYIKDMAKDSDYKFSLQFE--ELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGA-DYINANYIPGYNSPQEYIATQGPL
|....|  .. ..  |.| .|| .||  . . |  |..  ... | |. ||||.||..|| |||.| .. ....  |||||||| ||.  ...|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFtEEPIAYGDITVEMISEEEQDDWACRHFRINY--------ADEMQDVMHFNYTAWPDHGVP
..| .|||.|. .|...||||.|. .|. | ||| |||  .|.. || ..| .|.||     . |.. |.         .|. . |....|| |||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

TANAAEsiLQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQ
. .. .  |.||.   .   .  ||...|||||||||||.|.|| ||. |.... |...|..  .|. |  .|||||||||.|. .. . . |...
ehslpv..LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 917-1193 1.9e-86 285.0 In-house 4-280 (319) alignment 
Range on Protein: 917-1193
Range on HMM: 4-280/319.0
PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDiPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPE
.......  ..| .|. .. ..  .|..||  . |     |. . |. ||||.|||.|| .|| | .... ||.|||||..| ||.  ...||||.|| .
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPfTEEPIAYGDITVEMISEEEQDDWACRHFRINYA-DEM--QDVMHFNYTAWPDHGVPTAnaAES
| .|||.|| ...| |.||||. .|| .||. .||| .|..  || ..|.. .|||..|.  |.. .| . .|.   .|.|| ||.||||.||.   | |
tiedfWrmvWeeessivvmltklveklkvklkkywp.eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek..ats

ILQFVHMVRQQATK-SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
.|.... .|.   | ..||...|||||||||||||.||  |....  . .|.   ||..|  |  |||..|||.||.. . 
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeall
0045098 (Phosphotyrosine protein) phosphatases II 932-1200 1e-85 282.8 In-house 3-276 (278) alignment 
Range on Protein: 932-1200
Range on HMM: 3-276/278.0
KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRlvsmneeegaDYINANYIPGYnsPQEYIATQGPLPETRNDFWKMVLQQKSQ
........|.||.| | |     . | .. |. ||||..|||||.|||.          |||||.||.||  |...||||||||.| .|||.|. .....
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

IIVMLTQCNEKRRVKCDHYWPFtEEPIAYGDITVEMISEEEQDDWACRHFRIN------YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQA
.|||||.. |. |.||..|||  .... |||.||...|||. ||.  |....       . .|   | |..|. |||||||. .   |.|... ..|.  
vivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefireal

TK-------------SKGPMIIHCSAGVGRTGTFIALDRLLQHIrdHEFVDILGLVSEMRSYRMS-MVQTEEQYIFIHQCVQLMWMKKK
 .             |.||...|||||||||||..|.. .|...  .. ||.|  |.|.||.|.  .||..|||.|............|
kllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
Y_phosphatase Protein-tyrosine phosphatase 962-1193 1.5e-85 281.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 962-1193
Range on HMM: 1-234/235.0
NRCKNRYTNILPYDFSRVRLvsMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP-FTEEPIAY
|. ||||..|||||..||.|   ..|.  |||||||. ||......|||||||..| .|||.||.|.|...|||||...|| |.||..|||  .||.  |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVEMI-SEE-EQDDWACRHFRINYADEMQ---DVMHFNYTAWPDHGVPtaNAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH
|||.||.  .|. ...... |.....  .| .    |... ||.|||||||  . ..|.|.....|... ....||...||||||||||||.||| ||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
....| ||.| .|.|.|. |..|||..|||||......
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 962-1193 1.5e-85 281.8 In-house 1-234 (235) alignment 
Range on Protein: 962-1193
Range on HMM: 1-234/235.0
NRCKNRYTNILPYDFSRVRLvsMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP-FTEEPIAY
|. ||||..|||||..||.|   ..|.  |||||||. ||......|||||||..| .|||.||.|.|...|||||...|| |.||..|||  .||.  |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVEMI-SEE-EQDDWACRHFRINYADEMQ---DVMHFNYTAWPDHGVPtaNAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH
|||.||.  .|. ...... |.....  .| .    |... ||.|||||||  . ..|.|.....|... ....||...||||||||||||.||| ||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
....| ||.| .|.|.|. |..|||..|||||......
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 932-1193 1e-83 276.0 In-house 23-287 (298) alignment 
Range on Protein: 932-1193
Range on HMM: 23-287/298.0
KDSDYKFSLQFEELKLIGLDIPHF---AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQ
| .  ...|.|..|. .  .|...   .|  | |. ||||..|...|.|||.| .....| .||||| .. .|.  . .||||.||.|| .|||.|| ..
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvtee

KSQIIVMLTQCNEKRRVKCDHYWPfTEEPIAYGDITVEMISEEEQDDWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPTanAAESILQFVHMVRQQAT
... |||||. .|. ..|. .||| .|.   ||.|||.. |.||. | ..|.. .. ..  . . | ....| |||.|||.   |.|.|.... ||.. .
digtiVmltnleeldktkyhkywP.degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe..natsvldllrkvrasqq

KSK-GPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
...  |.|..|||||||.|||||.| .|....  . ||..  |  .|  |. .|||||||.||.. |.
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
0040439 (Phosphotyrosine protein) phosphatases II 956-1197 1.1e-83 275.9 In-house 5-247 (249) alignment 
Range on Protein: 956-1197
Range on HMM: 5-247/249.0
AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFtE
 | || |. ||||..|||||.|||.| .... .. |||||.||.||......|||||||||| .|||.|. ......|||||.. |. |.||..|||  .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

EPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVP-TANAAESILQFVHMVRQQAtKSKGPMIIHCSAGVGRTGTFIALDRL
... |||.||...|.|. ||. .|....   | .|   |.|..|| ||||||| . . . .... |. ..... ...||...||||||||||||||.. .
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylm

LQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWM
|.... .  ||..  |...||.|. .||..|||.|......  ..
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 959-1194 4.4e-83 273.7 In-house 6-241 (245) alignment 
Range on Protein: 959-1194
Range on HMM: 6-241/245.0
LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFtEEPI
|| |. ||||..|||||..||.| ....... |||||.|..||. .. .|||||||||| .|||.|. ......|||||.. |. ||||..|||  .|..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

AYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVHMVRQQatKSKGPMIIHCSAGVGRTGTFIALDRLLQH
 |||.||...|||  ||. .|....   . || . |.|. |. |||||||.  .  ...|.||. ....  .|.||...||||||||||||||....|..
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleq

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
.. .  |..   | |.||.|. .|||..||.|...... 
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 956-1199 1.1e-80 265.7 In-house 34-280 (290) alignment 
Range on Protein: 956-1199
Range on HMM: 34-280/290.0
AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-
|.. . |. |||| .|||||.||| |  ..|||| ||||||.| | ....||||.|||||.| .|||.|. ... .|.||. .  |  . ||..||| . 
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

EEPIAYGDITVEMISEEEQD-DWACRHFRINYADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLL
||.. .|...|....|.  | |.  | ....  .| . |  |.||||||||||..  |.|.|.....||.  .... |...||||||||||| ||.|   
eeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPss..aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvr

QHIRD---HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
. ...    | .|.  || |.|  | ..|||.||| .....|  .  |.
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 916-1200 4.2e-80 264.2 In-house 2-287 (305) alignment 
Range on Protein: 916-1200
Range on HMM: 2-287/305.0
NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIglDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP
... |||..||||.. ..|| ..  |...|     . . .      |. |||...| ..|..|..|   .... .|||||.|. ||.. ..||..||||.
kiialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE-EPIAYGDITVEMISEEEQDDWACRHFRINY---ADEMQDVMHFNYTAWPDHGVPTanAA
.| .|||..... | . |||||.  |  . ||  ||| .. |.  .|...||. ||..  |.  |...|      .| . |.... | |||||||.   |
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpq..fa

ESILQFVHMVRQQATKSKG-PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
 |.|.... |...  |.|| |...||||||||||.|||.|  |....  | ||. ... ..|| || |||| .|| |.|. ....    .
tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_PTPN6_pd Subfamily PTPN6 955-1201 1.3e-79 262.3 In-house 47-301 (306) alignment 
Range on Protein: 955-1201
Range on HMM: 47-301/306.0
FAADLPLNRCKNRYTNILPYDFSRVRLVsMNEEEGADYINANYIP--GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP
  .. | |..|||| ||||.| .|| |   ..  |.||||||||     .| ..|||||| |..| .|||.||.|..|..|||.|. .|. . || .|||
kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP

FTEEPIAYGDITVEMISEEEQDDWACRHFRIN---YADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSK----GPMIIHCSAGVGRTGT
 .||  .||.|.|...||....|.  |.....    ..| ..|.......|||||||.    . .|.|.. |.... ...    ||...|||||.|||||
deeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd..pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGt

FIALDRLLQHIRDHEF---VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLmWMKKKQ
|| .| ||. |. . .   .||  ||  .|..|  .||||.|| |... ..  ....|.
fiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk.yietkk
subfamily_PTPRK_pd Subfamily PTPRK 918-1192 2.1e-79 261.6 In-house 4-273 (314) alignment 
Range on Protein: 918-1192
Range on HMM: 4-273/314.0
VQLDDFDAYIKDMAKDSDYKFSLQFEELKlIGldipHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPET
.. .|    |. . .   | |  ..| |   |      ||    || |||...||.|| |||.|......  .|||||..| .|. |...|.|||||.||
irvadllqsiallkraegygfkeeyeslf.eg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqet

RNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPftEEPIAYGDITVEMISEEEQDDWACRHFRINY----ADEMQDVMHFNYTAWPDHGVPTAnaAES
 .|||..|.....  |||||.  |. |||| .|||  |.   |||| ||... | . .   | ||..      .|.. | .|....||||.||.   |..
vkdfWrlvydencasivmltelvevgrvkClkyWP..edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs..atg

ILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
.|..|. | ..  ...|....||||| ||||||||.| .|. |. .. ||.   | ..||... ||.|||||.||.. .
llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Ptp69D_pd Subfamily Ptp69D 917-1208 4.7e-79 260.7 In-house 3-298 (307) alignment 
Range on Protein: 917-1208
Range on HMM: 3-298/307.0
PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPE
....|| .  .|   .|.|. .   .|.|.    |    ...   | .|||| .| ..|  ||.|  .| .| .|||||..| ||.  ...|| |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTeEPIAYGDITVEMISEEEQDDWACRHFRINYAD-------EMQDVMHFNYTAWPDHGVPtaN
| .|||.|. .|....||||.. .|| | ||..|||   . . |||| |...|||...|.. |.. .   .       . . |. ..||.|.|  ||  .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP..e

AAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDV
.|...|.....||.   ....|...||||||||.|.|.||| |||...  . |||   | ..|| |  .||  |||.|... .  . .. . . .. |.
vargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl
subfamily_PTPRA_pd Subfamily PTPRA 915-1197 7.6e-79 260.0 In-house 11-296 (330) alignment 
Range on Protein: 915-1197
Range on HMM: 11-296/330.0
TNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPL
  |. .....  |.  . |   .|  .|. |    ..    .|.   |. |||. |||||||||| |  .. .| .||||| .| ||.  ...||.|||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

PETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPfTEEPIAYGDITVEMISEEEQDDWACRHFRINYA-D-----EMQDVMHFNYTAWPDHGVPTA
 || .|||.|. .|||. |||||. .|... ||  ||| .|  ..||.|.||.  |..  |.. |.| ..   |     . . |  | .|.||| |||. 
eetvedfwrmiweqksativmltelkerkeekcaqywP.deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

naAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWM
  .  .|.... |...  .| ||...|||||||||||||.|| .|. ..  . ||. . |...|  |  ||||.||| ||.. ..  ..
..piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 957-1197 5.4e-78 256.8 In-house 23-269 (274) alignment 
Range on Protein: 957-1197
Range on HMM: 23-269/274.0
ADLPLNRCKNRYTNILPYDFSRVRLVSMNE-EEGADYINANYIPGYNSP-QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT
 |.. .  ||||..||| . ||| | | .  .| ..||||||| ||.   . |.|||||||.| .|||.|. |...|.|||||. .|... || .|.| .
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

EEP---IAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMV---RQQATKSKGPMIIHCSAGVGRTGTFIA
|.      |||. ... .  |..|.  |.. ..|. . ..|.|. ||.|||| .|    |...|..|. |   |.....  .|...|||||.|||| |||
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWM
 .  ....|....||.|..|...|  |  ||||.||| .||. . | . 
isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN9_pd Subfamily PTPN9 922-1192 3.6e-77 254.3 In-house 5-286 (297) alignment 
Range on Protein: 922-1192
Range on HMM: 5-286/297.0
DFDAYIKDMAKDSDYKfslQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDF
.. ||.|.. |   .|   ...|..         |. |..|  |||||..| || .|| | ...|.| .||||||.. ||. .. .|||||||..| .||
elvayvkekgkrGlsk...eyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE-EPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTanAAESILQFV
|.|| .|.  .||| |.. |..|.|| .||| .| . . .||..|. .. ||..|.  | . |.    .|.. |.|| ...|||.|||   .|.|.|...
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPs..saaslldvl

HMVRQQA-TK------------SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
..||..  .             |. |...|||||.|||||||.||  |..... . ||.   |. .|. |  ..||.||| | ...|
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
0037934 (Phosphotyrosine protein) phosphatases II 956-1195 4.2e-77 254.3 In-house 4-241 (243) alignment 
Range on Protein: 956-1195
Range on HMM: 4-241/243.0
AADLPLNRCKNRYTNILPYDFSRVRLvsmneeEGADYINANYIPGYNspqEYIATQGPLPETRND----FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
 | || |. ||||..|||||.|||.|      || ||||||.|....    .|||||||||| .|    ||.|. ......|||||.. |. |.||..||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PftEEPiAYGDITVEMISEEEQDDWACRHFRINY---ADEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVHMVRQQ-----ATKSKGPMIIHCSAGVGR
|  .|   |||.||...|||. ||.  |.... .    |. . |.|. |..|||||||.  .   ..|..|. . ..     | .|.||...||||||||
p..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTFIALDRLLQHIrdhEfVDILGLVSEMRSYRMS-MVQTEEQYIFIHQCVQLM
|||.||.. .|...   . ||..  | ..|. |.  .|||..||.|...... .
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 916-1192 1.3e-76 252.5 In-house 4-275 (315) alignment 
Range on Protein: 916-1192
Range on HMM: 4-275/315.0
NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLdIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP
.|. ||.. .|. .    .   |  ..| .    |  |   |    |. |||| ||..|| |||.|  .. ....||.|||.|.||| .. |||.|||..
qpipldqlityvaqkkastkngfkqdyesipggql.hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPftEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTanAAESIL
.. .|||..| ...   |||||.  |. . |...|||  .. . || ||| ..||| ......| . . . |....|. ..||.||| |||    . ...
asvkdfwrlvfeedigkivmltnlvegekrkaekywp..dkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpk..ytiplm

QFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
...  |.|  |.| |....|||||||||||||.|| .|...   . .|.  ..  .|. |. |||. ||| ||.. .
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 959-1193 3.2e-76 250.9 In-house 6-239 (250) alignment 
Range on Protein: 959-1193
Range on HMM: 6-239/250.0
LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVkCDHYWPfTEEPI
 | |. ||||..|...| ||| | . . .. .||||| .. ||.  . .|||||||..| .|||.|||..||. |||||. .|. .. . .||| .|.. 
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vekae

AYGDITVEMISEEEQDDWACRHFRINYADEMQD--VMHFNYTAWPDHGVPTanAAESILQFVHMVRQQATK-SKGPMIIHCSAGVGRTGTFIALDRLLQH
 |||.||.. |.||  |.  |.. .  | . ..  | ......||| |||    |...|.... |...  .  ..|.|..|||||||.|.|||.| .|..
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPe..vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
..  . ||.  ..  .|  |. .|...|||.|... ..
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiil
subfamily_PTPN3_pd Subfamily PTPN3 942-1198 1.6e-74 245.4 In-house 21-277 (280) alignment 
Range on Protein: 942-1198
Range on HMM: 21-277/280.0
FEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEeegaDYINANYI----PGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT
||.|     ..   || .| |  |||| .|||||  ||.|.. .     |||||||.    |. .  . ||||||||..| .|||.|| .|||..|||||
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPTANaaESILQFVHMVRQQATKSKGPMIIH
.  |. |||| .||| ||. . ||...|.. .|.|.  .. |.. .. ..  | . .... |.||||||||. .  ...|.||. ||.. . .. |...|
tlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds..adflefvervrklrsgkeePvvvh

CSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMK
||||.|||| .|.|.  |. |  .| | .| .|..||  |...|||..|| |. ...  ....
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 938-1194 1.5e-73 242.7 In-house 20-276 (515) alignment 
Range on Protein: 938-1194
Range on HMM: 20-276/515.0
FSLQFEELKliGLDI-PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML
|| .| .|   | .| |   |.  .|  |||| |||||| .||.|  .|..   ||.|| |||.... . |||.|||.. . .|||..|||..   |.|.
fseefhdlp..gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TQCNEKRRVKCDHYWPF-TEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIH
|. .|  ..|| .|||    . . .| | ||..| |   .   |....   |... |  |..| |||.|||    . |.|.... |. .  . . |.|||
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh..tssllklikevkadhgqythpliih

CSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ--L
||||||||| .|..|  . |... . ||.. .|  .|  |. .|||.||| ||.. |.  |
csaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 962-1195 1.6e-73 242.0 In-house 20-263 (270) alignment 
Range on Protein: 962-1195
Range on HMM: 20-263/270.0
NRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYN-SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEP---
..  |||..|||   .|||| ...|.. . ||||||..|.. ....|||..|||| | ..||.|....|.. |||.|. .|| | ||. |||   .    
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

IAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANA----AESILQFVHMVRQQATKS-K-GPMIIHCSAGVGRTGTFIALDR
...|.|.|  .||| .. .  .. |...  | . ..|| |..|||||||...     ....|. .. ||.. ..  | .|...|||||||||||.|||| 
ledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

LLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLM
 .. .  .. ||.| ...|.| .|| .||. ||| |... |.. 
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 937-1193 7.7e-72 236.8 In-house 20-274 (315) alignment 
Range on Protein: 937-1193
Range on HMM: 20-274/315.0
KFSLQFEELKliGLDI-PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVM
 || .| .|   . || .. .|  . |  |||| ||||.| .||.|  ....   ||||| ||..... . |||.||||. . .|||.||||.|   |||
lfseefhdlp..dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LTQCNEKRRVKCDHYWPF-TEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAaeSILQFVHMVRQQATKSKGPMII
.|. .|  ..||  |||    . . .| | ||..| | . |   |.. .  ..| . |  |..| |||.||.   .  |.|.... |. .  | . ....
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkadngkkefsllv

HCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
|||||||||| .|..|  ...|.. . ||.. .| ..|. |. .|||||.| ||.. |.
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 916-1195 1.2e-69 229.8 In-house 8-283 (297) alignment 
Range on Protein: 916-1195
Range on HMM: 8-283/297.0
NPVQLDDFDAYIKDmAKDSDYkFSLQFEELkLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSpqEYIATQGPLP
.|. | || ....   ...|. || .|  | .     |   |.  .|  |.||.||||||.|||.| ..|..  .||.|| ...|..   ..|.|| | .
rpiplsdfatlvqk.nrhtdv.fseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

ETRNDFWKMVLQQKSQIIVMLTQCNEKRRvKCDHYWPFTeEPIAYGDITVEMISEEEQDDWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPTANAAES
.| .|||.|||... ..||||.. ||. . || .||. .    ..||..|.. | .|.     |.. ..  .    . |  .... |||. |.  . |.|
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdk.gvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

ILQFVHMVRQQA-TKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLM
.|.... ||..  ....||...||.||||||| ....|  . ...... |||.|||. .|  |. .|||.||| |... |  .
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_PTPN13_pd Subfamily PTPN13 962-1192 1.2e-69 229.6 In-house 37-265 (273) alignment 
Range on Protein: 962-1192
Range on HMM: 37-265/273.0
NRCKNRYTNILPYDFSRVRLvsmnEEEGAdYINANYIP--GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPI
|. |||| |.|||| .||.|    ..||. ||||..|     .   ||||.||||||| .|||.|| .||...|.|.|.  || .|||. ||| . ....
nkdknryrnvlPydetrvkl....gdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

A-YGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATkSKGPMIIHCSAGVGRTGTFIALDRLLQH
  .. ..||..  ...|... |.. ..   . | ..|.|.|...|||||||..  |...||||  ||. .| ..||...|||||.||.||.|..| .|. 
kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlgl

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
|   . .|.  .| ..|  | ..|||..||||... .
ierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 918-1193 3.9e-67 221.1 In-house 2-280 (290) alignment 
Range on Protein: 918-1193
Range on HMM: 2-280/290.0
VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG--ADYINANYIPGYNSPQEYIATQGPLP
...|.|  ..    .  . .|  ||. |.    .     .  . |. .||..||..||  |. |  .....    .|||| || ||.  ..|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIaYGDITVEMISEEEQDDWACRHFRINYADE---MQDVMHFNYTAWPDHGvPTANAAE
.|  ||||.. |.|. ||||||. .|. .|||  ||| ..    || .......||. ..   |.....  ..    | |.... |.|...|   .| . 
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.kvtnpqt

SILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
..|.. .|...|  . ......|||..|||...|.|..  ... .    .|.. .. ..|. .. .|||..|| .|.| | 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 920-1194 2e-66 218.9 In-house 4-276 (287) alignment 
Range on Protein: 920-1194
Range on HMM: 4-276/287.0
LDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL-PLNRCKNRYTNILPYDFSRVRLVsmneEEGADYINANYIPGYNSPQEYIATQGPLPETR
.. |. ....  . ..  |. ||  |. .. .  .   .. . |. |||.|.||..|  || |     .|  ||||| .| ||.. ...|....|. .| 
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnta

NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEpIAYGDITVEMISEEEQDDWACRHFRINYAD---EMQDVMHFNYTAWPDHG-VPtaNAAESI
 .|||.. ... ..||||.| .|. . .| .||| ..  . .|. ..|...|| ....  |.....  .   . | |. ...|.|...| |.  . . ..
rnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvt..epqtil

LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
|.. .|...|  ........|||..|||...|.| .  ... .    .|.. .. ..|  .. .||| |||.|| . |. 
lvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_PTPN1_pd Subfamily PTPN1 943-1192 4.8e-66 217.4 In-house 13-267 (290) alignment 
Range on Protein: 943-1192
Range on HMM: 13-267/290.0
EELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEeegaDYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK
....    |.|. .|.|| || .||| .. ||| ||..| . .     |||||. .   .  ..|| ||||||.| . ||.|| .|||. .||| .. ||
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvek

RRVKCDHYWPFTEE--PIAYG--DITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTANAaeSILQFVHMVRQQAT--KSKGPMII
...|| .|||  ||   . .    ..|..||||... .  |.....   ..| ....|| ||.||| ||| . |  . |.|.. ||.  .  . .|| .|
eqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespa..aflkflfkvresGslssdvGpavi

HCSAGVGRTGTFIALDRLLQHIRDHEF---VDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
|||||.||.|||. .| .| .| ...    |||   . |.|.||. ..|| .|  | .. .
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 921-1192 5.1e-65 214.9 In-house 14-287 (319) alignment 
Range on Protein: 921-1192
Range on HMM: 14-287/319.0
DDFDAY-----IKDMAKDSDYKFSLQFEELKLIGLDIPHF-AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPL
.||.||     .|. ..|   |.  .|  .  .| .      |.|. |. |||..|||..| ..|.|  .. ||..||||| .. || ... |||.||||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

PETRNDFWKMVLQQKSQIIVMLTqcnekrRVKCDHYWPFtEEPIAYGDITVEMISEEEQDDWACRHFRINY---ADEMQDVMHFNYTAWPDHGVPTANaa
..| .|||.|. ....  ||.||      . ||  |||  .  | ..   |.. | || .... |....       .....  | .  |||.|||     
dntladfWrmiweyncstivllt......kdkcsqywpl.kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp..

ESILQFVHMVRQQATKSK--GPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
  ....|. ||   .| .   ....||||||||||..|.|| ||. ... . ||.  .| ..|  |  .||   || ||.  .
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 957-1193 1.2e-63 210.3 In-house 20-252 (284) alignment 
Range on Protein: 957-1193
Range on HMM: 20-252/284.0
ADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTqcnekrRVKCDHYWPFtEE
|.|. |. |||...||..| ..|.|  .  ||..||||| .| || ... ||||||||..| .|||.|. ....  ||.||      . ||  |||  . 
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl.ki

PIAYGDITVEMISEEEQDDWACRHFRINY---ADEMQDVMHFNYTAWPDHGVPTANaaESILQFVHMVRQQATKSK--GPMIIHCSAGVGRTGTFIALDR
 | ..   |.. | || .... |....       .....  | .  |||.|||  .    ....|. ||   .| .   ....||||||||||..|.|| 
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp..sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

LLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
||. ... . ||.  .| ..|  | ..||   || ||.  . 
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 962-1192 3.6e-63 208.0 In-house 3-235 (237) alignment 
Range on Protein: 962-1192
Range on HMM: 3-235/237.0
NRCKNRYTNILPYDFSRVRLVSMNEEegADYINANYIPGYN-SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAY
|. |||| ||  || ||| |     .  .|||||.|. |.. .|..|||.||||  . .|||.|| |.|  .|||||   |. ..|| .||| |..| ||
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDITVEMISEEEQDDWACRHFRINYADEMQDV---MHFNYTAWPDHGVPTANAAesILQFVHMVRQQATK--SKGPMIIHCSAGVGRTGTFIALDRLLQH
| .|| .  .||  |.. | . . .  ....|     ...|.|||.|||   ||  .|.| . . ... .    || |||||||||||| |. .| .|..
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
 .... |||   |  .   |  ..||..||.|||| .
akekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 952-1206 1e-61 203.9 In-house 38-298 (325) alignment 
Range on Protein: 952-1206
Range on HMM: 38-298/325.0
IPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEkRRVKCDHYW
| . .| .| |. |||. |....| ||| |......  .|||||.|.  .   . ..|.| ||..| ||.|..||. .. ..|.| . ..    .|  ||
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldl.gkdrcavyw

PFT-EEPIAYGDITVEMISEEEQDDWACRHFRINYADE--MQDVMHFNYTAWPDHGVPTANAA-ESILQFVHMVRQQ--A-TKSKGPMIIHCSAGVGRTG
|    .   .| . |.... ||  |.  | . .  ...   . |  |.. .|.| ||.   |.  |||| |. | ..  | ||. .|...||||||||||
pkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

TFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCIS
.||.|  .|... ..  |||.| |  .|  | |||.| .|||.|....  ..|  . .  .|
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs
subfamily_PTPN23_pd Subfamily PTPN23 962-1192 8.1e-61 200.4 In-house 43-276 (288) alignment 
Range on Protein: 962-1192
Range on HMM: 43-276/288.0
NRCKNRYTNILPYDFSRVRLVsmneEEGADYINANYIPGYNS--PqEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPI
.  |||...||||| .|| |     ..  ||||| .. .  .  | ..||||.||..| ||||.|| .|||..||||.. .|. . |.|.|||   .|. 
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

AYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQ----QATKSKGPMIIHCSAGVGRTGTFIALDRL
 .||..| . |..| . .  |.....   ||....|.| ..|.||..||| .   |..|||.. |..    .  ||| |...||||||||||.|  .   
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPas..PetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaa

LQHIRDH-EFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
.. .. .   .||. .|| .|  |  |||..||. |  . |
vrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 912-1198 7.3e-59 193.9 In-house 6-279 (287) alignment 
Range on Protein: 912-1198
Range on HMM: 6-279/287.0
RKLTNPVQlDDFDAYIKDMaKDSDYKFSlQFEELKLigldiphfaadlplnRCKNRYTNILPYDFSRVrLVSMNEEEGADYINANYIPGYNSPQEYIATQ
|. .. |.  ..||  .|  . | . |  . |||                   ||||...||.| .|| |.| . | |.|||||||...|.  ...||.|
rrvkddvd.kevdalkeds.esstatfk.aaeelaa...............vkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaq

GPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEE-QDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTA
||.. | .|||..||...|  ....|.  |. | || .|||  | |.  |  .| ... .  . ... | .|.  ..  .   |  ... .|||.... .
gPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPt

--NAAESILQF-VHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMK
    .  .|.   |.  .. ..  ||...|...|.||.|...|.  |..   |   ||.   |  .| || ..||.  |. .. . .   .  
avglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 937-1192 4.1e-58 191.5 In-house 7-262 (283) alignment 
Range on Protein: 937-1192
Range on HMM: 7-262/283.0
KFSLQFEELKLIGL-DIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEeegaDYINANYIP---GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQI
.. |..| || ... | .   |    |. |||. .|.|.|  ||.| | ..    ||||| .||    |.  ..||..|.|| .|. |||||| ..|   
nnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IVMLTQCNEKRRVKCDHYWPfTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQD---VMHFNYTAWPDHGvpTANAAESILQFVHMVRQQATKSK
|||||.  |  |.||  |||  .  . ||. || .  |  .. .  . . ...    ..   . |. .  | . |       .|...|  .. .|  . |
ivmltklqedlrikCsqyWP.krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg..eqaiinslvkfnkvislqteskk

GPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
||...|||.|.|||..|||.   ..... .  ||.   |  ||  || .||| .|| ..|. |
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0051429 (Phosphotyrosine protein) phosphatases II 990-1196 3.6e-57 189.3 In-house 4-225 (272) alignment 
Range on Protein: 990-1196
Range on HMM: 4-225/272.0
ADYINANYIPGYNS---PQEYIATQGPLPETRNDFWKMvLQQKSQIIVMLTQCNEKRRVKCDHYWP-----------FTEEPIAYGDITVEMISEEEQDD
 .||||....||..   |  .....|||| | .|||..  ...   ||.|....|. |.||| |||           .....| ||...| ..||| ..|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

WACRHFRIN---YADEMQDVMHFNYTAWPDHGVPTanaaESILQFVHMVRQqatksKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVD--------I
. .|....    .|.|.  |||. ||.|||||||.    |..|........     .||...|||||..||||..||..||. . ..  ||        .
yilrellltlllsagearevmhlhytdwpdhgvpq....eallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMW
.. |.|.|..|. .|||||||.|...... ..
eeaveelraqrpgavqteeqylflyeallell
subfamily_PTPN14_pd Subfamily PTPN14 940-1192 3.2e-55 182.3 In-house 27-292 (300) alignment 
Range on Protein: 940-1192
Range on HMM: 27-292/300.0
LQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEeGADYINANYIPGYNS--PQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT
 ..|...   .|    .| || |  |||. ..|||. .||.|.. .|.   .||||  |    .   ..||..||||. | .|||.|| .|. |.|||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

QCNEKRRVKCDHYWPFT---EEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPTA-NAAESILQFVHMVRQQATKSK--
. .|. . |. .|.| .   .. . .|   |     |. |  . . .....    | ..|.|. || |||||||   .   | |. |. ||.......  
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

----GPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
     |...||||||||||  |  | |.. .   | .||   .. .|  ||..|||  || |... .
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 918-1192 4.5e-55 181.8 In-house 2-275 (439) alignment 
Range on Protein: 918-1192
Range on HMM: 2-275/439.0
VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLD---IPHFAADlPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPL
|. |.|. ..... |. .  |.  ||... .  |   |  .||.   .. |||| .. ..|..|| |  .     . ||||||| ||  .. ||||||| 
vgrdefqehvekldknkqeifkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

PETRNDFWKMVLQQKSQIIVMLTQCNEKRRvkcdhYWPfTEEPIAYGDITVEMISEEEQDDWACRHFRINY----ADEMQDVMHFNYTAWPDHGVPTAna
 || .|||..|...|.  |||||.  |  .     ||| ... . ||||.| .  . |  ... | |..      ..  . |..| |.||||. ||.   
kettddfwrlviekktvtivmltnlvesyk.....ywp.sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..

AESILQFVHMVRQQ-ATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
|  .|.|.. .     ..  ||...||||||||||| ||||  |....  . ||| |.|. .|  |  |||.  ||.||...|
ashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0041856 (Phosphotyrosine protein) phosphatases II 962-1200 1.8e-53 176.1 In-house 1-175 (182) alignment 
Range on Protein: 962-1200
Range on HMM: 1-175/182.0
NRCKNRYTNILPYDFSRvrlvsmneeeGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTqcnekrrvkCDHYWPfteepiayg
|. ||||..|||||.||          . ||||||.. |.  ....|||||||..| .||..|. ... ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ditvemiseeeqddwacrhfrinyADEMQDVMHFNYTAWPDHGVPTanaAESILQFVHMVRQqatkSKGPMIIHCSAGVGRTGTFIALDRLLQHirdheF
                         .... .... |. |||||||.    ...|.|...|..    ..|| ..|||||||||||..|.. ....      
........................ellerlgiqylylpwpDhgvpd...ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
|..   |...||.|. ||.|..||.|..... .... ||
vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 957-1192 2e-53 176.0 In-house 3-237 (239) alignment 
Range on Protein: 957-1192
Range on HMM: 3-237/239.0
ADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYN-SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE
|   .|..||||.||. ||.||| |  ....  .|||||.|.  |. ||. |||||| .  .  |||.|. |..  .|||||   | .. || .||| . 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

epIAYGDITVEMISEEEQDDWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLL
    | .. | .   |   |.  | | ..     | . | .. .| |||.|||    | ..| . . . ...     | .|||||||||||.|. .| .|
..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
.. . .. |||.  |  .|  |  |||| |||.||| .|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 959-1192 2.2e-53 175.9 In-house 4-236 (239) alignment 
Range on Protein: 959-1192
Range on HMM: 4-236/239.0
LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYN-SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEep
  .|..||||.||. ||.||| |  ....  .|||||.|.  |. ||. |||||| .  .  |||.|. |..  .|||||   | .. || .||| .   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..

IAYGDITVEMISEEEQDDWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH
  | .. | .   |   |.  | | ..     | . | .. .| |||.|||    | ..| . . . ...     | .|||||||||||.|. .| .|..
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
 . .. |||.  |  .|  |  |||| |||.||| .|
akkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 917-1196 2.3e-53 176.0 In-house 3-238 (392) alignment 
Range on Protein: 917-1196
Range on HMM: 3-238/392.0
PVQLDDFDAYIKDMAKDSdyKFSLQFEELklIGLDI-PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP
|.   .| |....  . .   |. .| .|   | || |. .|  . |  |||| |||||| .||.|  ...    ||.|| |||.... . |||.||| .
pipvaqfpafveknrhsa..lffeefhdl..pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpna

ETRNDFWKMVLQQKSQIIVMLTQCNEKRrvkcdhywpfteepiaygditvemiseeeqddwacrhfrinYADEMQDVMHFNYTAWPDHGVPTAnaAESIL
 . .|||.||.|..   |.|.|. .|                                             |... |  | .| |||..||    . |.|
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkh..tssll

QFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV--QLMW
.|.. |. .  .   |.||||||||||||  |..| .. | .   .||.. .|...|  |  ||||.||| ||. .|  .|.|
kfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_CG7180_pd Subfamily CG7180 962-1201 3.2e-53 175.3 In-house 42-295 (296) alignment 
Range on Protein: 962-1201
Range on HMM: 42-295/296.0
NRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRvKCDHYWPFTEePIAYG
|| |||. ...|||. || | ... ||  ||||| |. ..  ..||| |..|  || ..||..| ..... .|.||.  . .. ..  ||| .     ||
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqyg

DITVEMISEEEQDDWACRHFRINYA------------DEMQDVMHFNYTAWPD-HGVPTA-NAAESILQFVHMVRQQA--TKSKGPMIIHCSAGVGRTGT
.| ||...|..  .   | |...               |   |..|..| |.  . ||   ||   ... |...|...   . .||.....| |..|.| 
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQ
..|.|  |. .. .| ||. . |  .|  |  .|.. |.| .| . .. . . .|.
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
0036282 (Phosphotyrosine protein) phosphatases II 990-1190 4.8e-49 161.7 In-house 2-164 (174) alignment 
Range on Protein: 990-1190
Range on HMM: 2-164/174.0
ADYINANYIPGYNSPQEYIATQGPLPetrndFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFteepiaygditvemiseeeqddwacrhfriNYADEM
 |||||... ..  . ..||.||||.     ||.|. .......|||....|. ..|| .|||                               .. |. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQatKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRdHEFVDILGLVSEMRSYRMSMVQTEEQYIFIH
. .... |. |||||||. .  .....||. ....  ...||...|||||||||||..|....|.... . .||.| || |.|..|. ||||..||.|..
rlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
subfamily_PTPRN_pd Subfamily PTPRN 956-1192 8.9e-48 157.5 In-house 50-288 (297) alignment 
Range on Protein: 956-1192
Range on HMM: 50-288/297.0
AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQ-EYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT
.|. . |  |||....|||| |||.| . ...|  |||||  |   .  .  ||||||||..|  |||.|| .| . .||.||. .|.   .|..||| .
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

EEpIAYGDITVEMISEEE-QDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDR
 .   |.   |...||    ||.  | | .    ..| . |  | . .||..|||..  | |.|.|   | .       |...|||.|.||||..|..| 
Gs.evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPas..aksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidl

LLQHI-RDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
.|... .    .||   .  .|  |  .|.|..|. |. ..|
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 959-1195 9.3e-48 157.4 In-house 37-292 (301) alignment 
Range on Protein: 959-1195
Range on HMM: 37-292/301.0
LPLNRCKNRYTNILPYDFSRVRLVSMNE--EEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-E
   |.  ||. || .||  |. |  ...      .||||.|| ||.. ...||.|||. .|  |||....|.| . |||.|. .|... || .||| . .
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

EPIAYGDITVEMISEEEQDDWAC-----------------RHFRINYADEMQDVMHFNYTAWPDHGVptANAAESILQFVH-MVRQQATKSKGPMIIHCS
|   .| .||....|    |.                   |.|... . . .||. .. | ||..||        .|| .. .. .|   ..||...|||
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv..vreprtvLqviddvihrqqkigggpvvVHCS

AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLM
..|.|.|......  |   .    ||. ...  .|  .. .|.| |||..|.. .. .
dtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
0043147 (Phosphotyrosine protein) phosphatases II 987-1197 6.1e-47 154.9 In-house 2-162 (172) alignment 
Range on Protein: 987-1197
Range on HMM: 2-162/172.0
EEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCnekrrvkcdhywpfteepiaygditvemiseeeqddwacrhfRINYA
.|| |||||.|...|  |...|||||||..| .|||.|. ... ..||.||..                                            .. 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

DEMQDVMHFNYTAWPDHGVPtanAAESILQFVHMVRQ-QATKSKGPMIIHCSAGVGRTGTFIALDRLLqhirdhEFVDILGLVSEMRSYRMSMVQTEEQY
.... .... |. |||||||    .| .|.|.. ... .| ...||...|||||||||||..|.. .|      . ....  |...|. |. .||...||
llerlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIHQCVQLMWM
.|.... .|...
rflyyfekllll
0049772 (Phosphotyrosine protein) phosphatases II 953-1193 2.3e-46 154.3 In-house 37-277 (314) alignment 
Range on Protein: 953-1193
Range on HMM: 37-277/314.0
PHFAADLPLNRCKNRYTNILPYDfSRVRLvSMNEEEGADYINANYIPGYnspQEYIATQGPLPETRNDF----------WKMVL--QQKSQIIVM-----
 . .|||.||| ||||..|||.| .||.| .  . .| |||||.|. |.   . .|||||||..| .||          |.|||  .... .|||     
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTQCNEKRRVKCDHYWPFTEepiaygditvemiseeeqddwA-------CrhfrinyadeMQDVMHFNYTAWPDHGVPtanAAE
                |... ..    . ..... .                             .           . .... .. .||...|     |
ladelsrLdaAlgKtpllildgngneptaadlellk.....................eelydpelf..........erlgikylripvpDgsap...lle

SILQFVHMVRQQatKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRdhefVDILGLVSEMRSYRM-----SMVQTEEQYIFIHQCVQ
 ...|......   . .|| ..||.||.||||||.... |. . .    |..   ....|. |.     ..... |||.||.....
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefileall
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 962-1193 5.6e-46 151.9 In-house 41-274 (307) alignment 
Range on Protein: 962-1193
Range on HMM: 41-274/307.0
NRCKNRYTNILPYDFSRVrlVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEE-PIAY
|  ||||...   | .|.  |   .   .||| |||.     |. .|..|||| .|. .|| |..|.| . ..|| .. |  ..||. |||  |    ..
ntdknryqdvkcqdkgri..vvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvf

GD----IT-----VEMISEEEQdDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAesILQFVHMVRQQatksKGPMIIHCSAGVGRTGTFIALDR
|.    |.     .. .. .|.       .....|.. . . |.... |||.|||  | .   . ... || .    . |...||||||||.|| .|.  
geapntisvanlgakklapded.linvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt..ainlleavryd....tnpvvvhcsaGvGrsGtivaisl

LLQH-IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
. .  |.  .  |.  || |.|| |   .||| ||...|. . 
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 963-1191 9e-46 150.8 In-house 57-278 (290) alignment 
Range on Protein: 963-1191
Range on HMM: 57-278/290.0
RCKNRYTNILPYDFSRVRLvsmNEEEGADYINANYIPGYNSPqeYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE-EPIAYG
  |||| ..   | .|| |   ..    ||. |||. | ...  .| |||.| .|  |.|.||||.|   |||| .  |. . ||..|.| .| | ...|
fkknrykdvvcndktrvil...kdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DITVEMISEEEQDDWAC-RHFRINYADEM--QDVMHFNYTAWPDHGVPTANAAesILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD
.|||    |...|.    . . .   |.     . |..  .|||. |. .. |  .|. ....|    |  ||...|||||.||||||.|..  || . |
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla..llrtlrilr....kasGpvvvhcsaGiGrtGtfvaievglqilld

HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQC
   .|.|.||  .|  |.. || . ||. . . 
Gkeldlldlvralrnsrlnsvqvdiqylalvei
subfamily_ptpA1_pd Subfamily ptpA1 961-1161 1.3e-45 150.8 In-house 46-260 (418) alignment 
Range on Protein: 961-1161
Range on HMM: 46-260/418.0
LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGyNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT---EEP
 |  ||||||||| ...||.|  ....||.|||||||| |   |...|.||||||.|  |||.|| ... .|||||.. .|. |.|||.|||     |. 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

I-------AYGDITVEM---ISEEEQdDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANaaESILQFVHMV--RQ-QA---TKSKGPMIIHCSAGVG
         .|  .||.   | . |. .   |  |. .  | .|. ...|  |||| .|     . . |..| .  || |    .  . |.|.|||||||
siygngnevfgtysvelveviqdper.eiitrnirltfegetrditqyqyegwpdhnipdht..qpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTFIALDRLLQHIrDHEF
||||| .   ..... || |
rtgtfctavimmkkl.dhyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 964-1192 1.3e-45 150.6 In-house 35-291 (297) alignment 
Range on Protein: 964-1192
Range on HMM: 35-291/297.0
CKNRYTNILPYDFSRVRLVSMNEeeGADYINANYI--PGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPIAY
 ||||..|| .| .||.|       . |||||.|.  |  ...  || .|||| .| .|||..| .|  ..|||... .|  | ||  ||| . .|    
rknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

GDITVEMISEEEqDDWAC---RHFRINYADEMQDVMHFNYTAWPDHGVPT---------------ANAAESILQFVH----MVRQ-----QAT-KSKGPM
||. || .|.   |..       ... | .| . | | .. .|||||||.               . |   .|  |.    ||       .|    . ..
gdvvveflssts.defdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayl

IIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
..||||||||.|  .  | .|. .| .   |.  ..| .|. |  .||| ||. .... |
lvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 958-1192 1.3e-44 146.9 In-house 33-265 (281) alignment 
Range on Protein: 958-1192
Range on HMM: 33-265/281.0
DLPLNRCKNRYTNILPYDFSRVRLVS-MNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEE
. |.|  ||||.||   | |||.|   | ... .||| ||||      . || ||||  ||| |||.|. |...  |||| |  |  | ||  |.|    
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

-PIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTanAAESILQFVHMVRQQATkskgPMIIHCSAGVGRTGTFIALDRLLQH
  . .  ..|.      .      .. . |  | . . |. .  |||  ||   ..| .|. .. .| ..|    | .|||||||||.||..|..  || 
cclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpe..ssevmlkilrkirarst....ppvihcsagvgrsgtlmaveialqs

IRDHE-FVDILGLVSEMRS-YRMSMVQTEEQYIFIHQCV
|. |  . ||  .|| .|   | . ||| .||..| . .
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
0046846 (Phosphotyrosine protein) phosphatases II 982-1197 2.5e-44 146.4 In-house 4-174 (176) alignment 
Range on Protein: 982-1197
Range on HMM: 4-174/176.0
VSMNEEEGADYINANYIPGYnspqEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAygditvemiseeeqddwacrhf
. . .... ||||||.| |.     .||||||||.|  ||..|..... ...|.||.. |. |.||..|||  |..                        
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

rinyademqdvmHFNYTAWPDHGVPTAnaaESILQFVHMVRQQATKSkGPMIIHCSAGVGRTGTFIALDRLLQhirdHEFVDILGLVSEMRSYRM-SMVQ
            .. .. |||||||.    | .|... ..|.. ..  || ..|||||.|||||..|.. |      . .....  ....|..|.  .||
............qylhlpwpDhgvpdl...elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavq

TEEQYIFIHQCVQLMWM
|.||| |......|...
tpeQyrflyefellllk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 932-1191 4e-44 145.6 In-house 2-254 (267) alignment 
Range on Protein: 932-1191
Range on HMM: 2-254/267.0
KDSDYKFSLQFEELKLIGLDIPHFAADLPL-NRCKNRYTNILPYDFSRVRLVSMNEEegadYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS
.|.. ..  .||..| |  .    .  ..  |. .||. . |||| .|| |   .||    |||| |. ||.  . .|.||.||  |  ||.... .|| 
edeeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkv

QIIVMLTQCNEKrrvKCDHYWPFT-EEPIAYGDITVEMISEEEQDDWACRHFRINYADEM-QDVMHFNYTAWpdhGVPTANAAESILQFVHMVRQQATKS
 .||.||.  .    .   .||    .   | |.|||   |.|..|.    . ... .|  ..|  . |  |    . | |       |  . ..|  . 
pvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqleng

KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQC
  |....||.||||.|||. .|  |. ..  . .||  .. ..|| |...|.| |.||.||. 
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
0049260 (Phosphotyrosine protein) phosphatases II 997-1190 9.3e-41 134.4 In-house 1-144 (152) alignment 
Range on Protein: 997-1190
Range on HMM: 1-144/152.0
YIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWpfteepiaygditvemiseeeqddwacrhfrinyademqdvmHFN
.|.||. |.|.||||||.|.| .|||.|. ... ..|||||.. |. ..||..|.                                          .. 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

YTAWPDHGVPTANAAESIlqFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLqhirdhEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ
.. |||||||.      .  ....... | ...|| ..|||||||||||..|.. .|        |...  |. .|. |. .|....|..|...
hlpwpDhgvpdlsqlllf..lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 961-1199 1.4e-40 133.8 In-house 54-292 (305) alignment 
Range on Protein: 961-1199
Range on HMM: 54-292/305.0
LNRCKNRYTNILPYDFSRVRLvsmNEEEGADYINANYIPGYNSPQ-EYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT--EEP
..  ||||...   | | |.|   ..   .||| |||.     |.  .|..|||| .| ..|| ||.|.| . |||| .  |  ..|| .||| .  |  
iaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

IAYGDITVEMISEEE----QDDWACRHFRINY-ADEMQDVMHFNYTAWPDHGVPTANAAEsiLQFVHMVRQqatkSKGPMIIHCSAGVGRTGTFIALDRL
   . | || .|       . .     ....|  |.   | |...| ||| ||| .. .   |...  .|     || |...|||||.||||| .|.. .
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklts..lellsairg....skvpivvhcsagigrtgtivaieyi

LQHIRDHEF-VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
|..| .      .  ||  .|  |   .|.. ||.|||. .   ...|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 963-1201 1.5e-38 127.3 In-house 49-291 (305) alignment 
Range on Protein: 963-1201
Range on HMM: 49-291/305.0
RCKNRYTNILPYDFSRVRLvsmNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAY--
. |||| ..   |  ||.|   .     .|| |||.     |. .| || || .|  ||| | ||.| . | || .  ||   || .|..  ....    
agknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

---GDITVEMISEEEQ-----D--DWACRHFRINYA-DEMQDVMHFNYTAWPDHGVPTANAAesILQFVhmvrQQATKSKGPMIIHCSAGVGRTGTFIAL
     |.| . | ..         .     . |. .  ... | |. .  ||| |||.|. |  ||...    ..|  ||||...|||||.||||. . |
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla..ilell....ekarpskgpivvhcsagigrtgsvvml

DRLLQHIRDHEFVD-ILGLVSEMRSYRMSMVQTEEQYIFIHQCVqLMWMKKKQ
. .|. .   . ..    ..  .|  |   .||..||.|.|| . | ...||.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi.lnyfrkkk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 962-1188 5.2e-37 122.2 In-house 50-273 (301) alignment 
Range on Protein: 962-1188
Range on HMM: 50-273/301.0
NRCKNRYTNIlPYDFSRVRLVsMNeEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPF-TEEPIAY
.. |.|| .. | . |    | .. .     | ||.||    |. .|||||||..|..||| |. | . . ||||.|  ||   ||..| |  ..| .  
pkdkhryptv.PckPstavev.iv.dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GDITVEMISEEE--QDDWACRHFRINYAD---EMQDVMHFNYTAWPDHGVPTANAaeSILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALDRLLQH
|  .... ..|   ...   |..... .    . . |.|..|. |.|.||| . |   . .....|.    ||. |...|||||.||. .||. . | ..
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksha..elfdlmelvk....ksekPivvhcsaGiGrsvafigteylare

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFI
.  .  ...   . ..|  | . |||..|  ..
veadptieltealkhlrehrwngvqtnsqlywm
PTPc_DSPc_SM00012 1092-1192 7.6e-37 121.1 In-house 2-103 (105) alignment 
Range on Protein: 1092-1192
Range on HMM: 2-103/105.0
VMHFNYTAWPDHGVPTANaaESILQFVHMVRQQATKSK--GPMIIHCSAGVGRTGTFIALDRLLQHIRDH-EFVDILGLVSEMRSYRMSMVQTEEQYIFI
|.|. ||.|||||||.    .|||.... |... .||.  .|...||||||||||||.||| |||..... ..|||. .|.|.|..|..||||||||.|.
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HQCV
....
yral
0044763 (Phosphotyrosine protein) phosphatases II 973-1199 5.4e-36 119.2 In-house 1-174 (178) alignment 
Range on Protein: 973-1199
Range on HMM: 1-174/178.0
PYDFSRVRLVSMNEEEGADYINANYIPGYnspqEYIATQGPlpetrNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEpiaygditvemiseee
|.|..|| | ..  .|..|||||..| ..     |.....|      |..... ... . ||.||.  |  ..|||.|||  ..                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

qddwacrhfrinyademqdvMHFNYTAWPDHGVPTanAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHirdheFVDILGLVSEMR
                    ... .. .||||||.    | .|.||.....   ...|| ..||||||||.||..|.. ....      ...   ....|
....................iqylhipipDhgvpd..llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

SYRMsMVQTEEQYIFIHQCVQLMWMKK
..|. .|....|. ..... . .. ..
erRp.ivpnpgqlrqLyefelrllkes
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 962-1200 9.5e-36 118.3 In-house 43-275 (288) alignment 
Range on Protein: 962-1200
Range on HMM: 43-275/288.0
NRCKNRYTNILPYDFSRVRLVsmneEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEE-PIAY
| ...||.|.   |..||.|     ..   ||.|| ..  . ..  | .| ||  | . .|||.|..  . ||||..  || . | ..|.|      . .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDItVEMISEEEQ-DD--WACRHFRINYADEMQD-VMHFNYTAWPDHGVPtanaaESILQFVHMVRQQaTKSKGPMIIHCSAGVGRTGTFIALDRLLQHI
| .   .. .. .  |       .||.   | .  | .  .  |.|.|||     |. | .....     . . |...|.|||||||||.|     |. .
grl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP.....enylsplrllevl.kslqkPivvhssaGvGrtgtlililialesl

RDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
| ..|. |  |....|  |.  .||| ||...|.||    . ||
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
0051082 (Phosphotyrosine protein) phosphatases II 990-1192 1.1e-35 117.7 In-house 3-149 (151) alignment 
Range on Protein: 990-1192
Range on HMM: 3-149/151.0
ADYINANYIPGYnspqeYIATQGPLPetrnDFWKMVLQQKSQIIVMLTQCNEKRrvKCDHYWPFTEepiaygditvemiseeeqddwacrhfrinyadem
 ||||..|. |.     .....|||.    ||.... ... . ||.|..  |    .| .|.| ..                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

QDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQqatKSKGPMIIHCSAGVGRTGTFIALDRLLQHirdhefVDILGLVSEMRSYRMSMVQTEEQYIFIH
 .|.|. .. |||.|.|.    ...|.|......   |..||...|||||.|||||..||...|..      |..   ..|.|..|. .||...|..|..
ievlhipildwpdpglpls..fdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

QCV
...
fal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 964-1200 5.5e-33 108.8 In-house 54-293 (310) alignment 
Range on Protein: 964-1200
Range on HMM: 54-293/310.0
CKNRYTNILPYDFSRVRLvSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDI
 ||||....  | |||.|  ..     ||| |||.      . .| .||||  |  |||.|..|.... |..| .  |. | ||  |||      .|| |
hknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygci

TVEMISEEEQDDWACRHFRINYA-----DEM------QDVMHFNYTAWPDHGVPTANAAeSILQfvhmvRQQATKSKGPMIIHCSAGVGRTGTFIALDRL
 |  .||  ..   |             ||         |   ..  ||| |||  .   .. |     |  |   .|| ..|||||..|... .||.  
rvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch.tvpq.....rllaqvrhgpcvvhcsagkdrlyvvvalklk

LQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQcVQLMWMKKK
.....  . ||.  ...|..  |.  .||| ||..|.. |.... . .
idkldrglkvdaeevktellksraiciqtelqyliidr.vriifarge
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 964-1190 2.6e-30 100.4 In-house 37-264 (285) alignment 
Range on Protein: 964-1190
Range on HMM: 37-264/285.0
CKNRYTNILPYDFSRVRLvsMNEEegADYINANYI--PGYNSpQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPIAY
  |||...   . .|| |   | .   ||| |...  || .    ||.|||||||| .|||.|. |.|   ..||    |    ||  |.|    | . .
dlnryadvrcieetrvvl..knhd..rdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GD--ITVEMISEEEQDDWACRHF-RINYADEMQDVMHFN---YTAWPDHGVPtaNAAESILQFVHMVRQQATKSKgPMIIHCSAGVGRTGTFIALDRLLQ
|   ||.    ||         .  ||  |   . ...|      |||.  |  . |  .... . |..   | | |. .||||||||| ||. .|    
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlap..edarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyati

HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ
.| .   ...| .| |||. |.  ||.  |..|.. 
rimenpniemldivremramrfqavqshmqflflyv
subfamily_egg_pd Subfamily egg 960-1198 1.1e-28 94.9 In-house 40-272 (307) alignment 
Range on Protein: 960-1198
Range on HMM: 40-272/307.0
PLNRCKNryTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKrrVKCDHYWPFTE-EPI
 |.....    .   |.|||.|   .     |.| ||.. |     |.| .| || .| .|||.|| |.. | |||||   |    .|..||| .| ...
nlekars..krvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

AY--GDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWpDhgVPTANAAESILQFVHMVRQQATkskgPMIIHCSAGVGRTGTFIALDRLLQH-
 .  | . .| .  ... |   |  ...     .. .. ..  . |  |  ..   | |. . ..|. ..    |.....  || ...|..|..  | . 
vtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.d..vnnssdvysplrvlrklrnlsk....pvvvqdilGvskaatlvaieiallsl

IRDHEF-VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMK
.|   .   .|  |  .|  |   |..  .|.|... | ...  
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 965-1197 2.2e-27 90.6 In-house 46-277 (312) alignment 
Range on Protein: 965-1197
Range on HMM: 46-277/312.0
KNRYTNILPYDFSRVRLVSmnEEegADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPF------TEEPI
 ||| ||  .|  |  |    .|    || ||..     |. ...||||| .|   ||...|   |  |..|.   |    || .|          |.  
lnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

AYGDITVEM-ISEEEQDDWACRHFRINYADEMQ--DVMHFNYTAWPDHGVPTAnaAESILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALDRLLQH
 | .   |. |    .|  . | ...      |   . |.....|||||.| .   .. |...  |.    | | |.| |||||||||||.. .. ..  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds..cdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmiaa

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWM
.|     ..      .|  |   |..  ||..  .||  . .
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 966-1208 3.3e-27 90.4 In-house 23-271 (290) alignment 
Range on Protein: 966-1208
Range on HMM: 23-271/290.0
NRYTNILPYDfSRVRLVSMNEEEGADYINANYIPgYNSPQEYIATQGPLPET---R----NDFWKMVLQQKSQIIVMLTQCNEKRRV----KCDHYWPFT
.|... |  . .|| |    .    ||| ||..  . . .. |.|| |. ..   |    ..|| |. | |.. .||| . .||..      | .| | .
qRlevpLvea.trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

EE-PIAYGDITVEMISEEEQDDWACRHFRINYADEMQ-DVMHFNYTAWPDHGVPTAnaAESILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALDRL
..  . ....||.  | |..||   |.  ... || .  | |  .  | .  |.      ..|. ...|.    .|| |.|.||  |. |  .. |..  
vgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqed..tktllsliqkvk....asktpvivHcvdGiSrsAalaaiilg

LQHIR-DHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDV
 | |   .. | .  .....|. |  ........ |.   . |. .. ..||. .. 
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeet
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 964-1072 1.6e-26 87.9 In-house 49-167 (350) alignment 
Range on Protein: 964-1072
Range on HMM: 49-167/350.0
CKNRYTNILPYDFSRVRLV-S-------MNEEEGADYINANYIPGY------NSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDH
 ||||.|||||. |||.|  |           .. |||||||.         |.   |||||.|||.| .||.|..|. | ..|..||.  |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPfteePIAYGDITVEMISEEE
||.      .| |||| . |  |
YWq....egsydditvklaskwe
subfamily_CG42327_pd Subfamily CG42327 963-1111 1.1e-25 84.9 In-house 29-182 (319) alignment 
Range on Protein: 963-1111
Range on HMM: 29-182/319.0
RCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYN-SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE---EPI
. |.|. |..|   .|| | .. ...   |..|.|. ||. .|  |||.| .| ..  |||..| .|.|..|| ||.  |.   .| .|.|  |   .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

AYGDITVEMISEEEQDDWACRHFRINYAD--EMQDVMHFNYtAWPDHGVPTANAA
.|||| | .   | .| .|   . ..  |  | ... |. |  |.. .||. .||
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaa
0048076 (Phosphotyrosine protein) phosphatases II 1086-1194 4.6e-25 83.4 In-house 41-141 (145) alignment 
Range on Protein: 1086-1194
Range on HMM: 41-141/145.0
ADEMQDVMHFNYTAWPDHGVPtaNAAESILQFVHMVRQQATKsKGPMIIHCSAGVGRTGTFIALDRLLQhirdhEFVDILGLVSEMRSYRMSMVQTEEQY
 .. . .... |. |||||||  . .| .|.|......   . .||...|||||||||||..|.. .|.     . |..   . ..||.|. .|....|.
ellerlgiqylylpwpDhgvp..dllellleflefieealke.ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgql

IFIHQCVQL
.|...... 
rflyefele
0048179 (Phosphotyrosine protein) phosphatases II 1083-1191 2e-24 81.3 In-house 48-140 (144) alignment 
Range on Protein: 1083-1191
Range on HMM: 48-140/144.0
InyademqdVMHFNYTAWPDHGVPtaNAAESILQFVHMVRQQATkSKGPMIIHCSAGVGRTGTFIALDRLLqhirdHEFVDILGLVSEMRSYRMSMVQTE
         .... .. |||||||  . .| .|.|......    ..||...|||||||||||..|.....     .. ...   . ..||.|. .|...
e........giqylhlpwpDhgvp..dllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnp

EQYIFIHQC
.|..|....
gqlrfLley
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1013-1200 9.8e-23 75.0 In-house 99-292 (302) alignment 
Range on Protein: 1013-1200
Range on HMM: 99-292/302.0
PLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP-FTEEPIAYGDITVEMISEEEQ-----DDWACRHFRINYADEM------QDVMHFNYTAW
|  .|.. .| .. | .  |.| |..  |.   || .|.    .. . .|  ||. .| ...     |  . . . ... .|       . |  . ..||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPT-ANAAESILQFVHMVrqqatksKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
|||| |  |..|  ||.|           |  ...|||||||||||..|.   .|    ..  |.| .|  .|. |   ||.|.| |..  ||    |.|
pdhGapkeaytaldilkfcesy.......kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek

K
.
a
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1091-1211 1.5e-21 71.3 In-house 90-208 (440) alignment 
Range on Protein: 1091-1211
Range on HMM: 90-208/440.0
DVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQ-QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIH
 . ...| .|||.|||    |  .|.... | . |   ..||...|||||.||||  ||.| .|.. .  . .||. ... ||. |  |||| ||| |.|
tlkqyhyqgwpdkgvpkf..agpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QCVQLMwMKKKQQFCISDVIYE
..|    .   . . . | | |
eavleg.llcgdtlileddite
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1017-1188 7.3e-21 69.4 In-house 40-213 (255) alignment 
Range on Protein: 1017-1188
Range on HMM: 40-213/255.0
TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPtaNAAES
| . |.... |.|.. .|||.  .|. ..||..|.|   .|   . |..|       .     ..   ...   . ..| |..|. |...  |  . |. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaP..elare

ILQFVHMVRqqatKSKgPMIIHCSAGVGRTGTFIALDRLLQ----HIRDHEFV--DILGLVSEMRSYRMSMVQTEEQYIFI
||. ...||    .|| ....|||.|.||. .|.  . . |     ..  | |  | | |. |.|| | . ..|  |  | 
ilnilkvvr....dsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1005-1190 1e-20 68.8 In-house 5-198 (199) alignment 
Range on Protein: 1005-1190
Range on HMM: 5-198/199.0
QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRIN----YADEMQDVMHFNYTA
. ||||| || ||  |||.|| .  |  |||. . . .. .    ||| ||     || ..|   .   . |..   . .          ... |...|.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTANAaesILQFVHMVRQQAT----KSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD--HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ
| ..  |       .. ||   |. .     .   |.|.||| | | || |.|||  ..   .     ||.. .   .|  |  .. . ..| ||.|
wkekttpnval...fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1005-1190 1e-20 68.8 In-house 4-197 (198) alignment 
Range on Protein: 1005-1190
Range on HMM: 4-197/198.0
QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRIN----YADEMQDVMHFNYTA
. ||||| || ||  |||.|| .  |  |||. . . .. .    ||| ||     || ..|   .   . |..   . .          ... |...|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTANAaesILQFVHMVRQQAT----KSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD--HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ
| ..  |       .. ||   |. .     .   |.|.||| | | || |.|||  ..   .     ||.. .   .|  |  .. . ..| ||.|
wkekttpnval...fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 962-1190 6e-20 66.0 In-house 47-273 (303) alignment 
Range on Protein: 962-1190
Range on HMM: 47-273/303.0
NRCKNRYTNILPYDFSRVRLVSmneeegADYINANYIpGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYG
|  |||.....  | |.|.|        . || |.|.   .| .  | || ||. |  |||.|...|| . ...|   .|  ..  |  .|  .. . . 
nmdknrfvdvicldhskvklsd......ssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

DITV---EMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA---ESILQFVHMVRQqATKSKgPMIIHCSAGVGRTGTFIALDRLLQ-
. ..   |.   |  | |. .   .   |    .    | |||   .|.  ..     | |   ..|.  ..|. | .    .|.||.|||  ..     
ersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrk.ysdst.ptvymslsgcgragtfalfetahls

HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ
   .   .|..  .  .|  |.  ||   |. ... 
lhseqasldlvkclenvrngrlhavqnlsqfsvvyt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 965-1200 1.1e-19 65.0 In-house 54-288 (302) alignment 
Range on Protein: 965-1200
Range on HMM: 54-288/302.0
KNRYTNILPYDFSRVRLvsmnEEEGADYINANYI--PGYNspQEYIATQGPLPETR---NDFWKMVLQQKSQIIVMLTQCNEKRRvKCDHYWP-FTEEPI
||. ...  .|  .|.|    |.|  .|.||  .  |  .  .. | .| |  ..    ..||.|| |.| . .|.| . .|  .   ....|  ...  
knqsedvpildsnlvkl....eaepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk

AYGDITVEMISEEEQDDWAcRHFRINY-----ADE-MQDVMHFnyTAWPDHGVPtANAAESIlQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRL
 ||.. |     |.... .  .. |       ..  .  | ..  | |... ||  . || | . .. | .. .|.. ...|    |.|| |.|..|   
eygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvl..tnWkqkkvp.vkyaeli.ktaakvfakkikadentvivSknGaGRagafltlava

LQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVqLMWMKKK
.... ... . |  .|  .|| | ..|.. .||.... .. |...|||
veklqkgkepnikeivksiRsqRpravdslkQyvslyial.llyikkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 964-1067 3.8e-19 63.2 In-house 50-165 (349) alignment 
Range on Protein: 964-1067
Range on HMM: 50-165/349.0
CKNRYTNILPYDFSRVRLV-----------SMNEEEG---ADYINANYI--PGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKC
.|||| .||||. |||.|            |  | ..    |||||||.  . ..  . ||||| ||| | .||.|..| .. .... |.. .|.   ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DHYWpfteEPIAYGDITVEM
| ||    .  .| .||| .
diyw....qelsysnitvkl
subfamily_hpo-7_pd Subfamily hpo-7 1017-1189 3.3e-18 60.6 In-house 46-220 (263) alignment 
Range on Protein: 1017-1189
Range on HMM: 46-220/263.0
TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPIAYGDITVEMIseEEQDDWACRHFRINY-A---DEMQDVMHFNYTAWPDHGVPTanAA
| . |.... |.|.. .|||.  ||. ..||..|.|   .|   . ...|     . |.|   .   .        ....| |. |. |...  |.   |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvctt..kvqsdvllktlellstlgeKkkthtvkhysykgWiekndpe..la

ESILQFVHMVRQQatKskgPMIIHCSAGVGRTGTFIALDRLLQ----HIRDHEFV--DILGLVSEMRSYRMSMVQTEEQYIFIH
..||. ....|.   |   ....|||.|.||.  |   . . |     ..  . |  | | |. |.|| | . ..|  |  |  
reilnilkvarns..k...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
subfamily_eak_pd Subfamily eak 968-1108 5.7e-18 59.4 In-house 57-197 (332) alignment 
Range on Protein: 968-1108
Range on HMM: 57-197/332.0
YTNILPYDFSRVRLVSMNEEeGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE-EPIAYGDITVE
  .|.|||.  ||| |   .    ||||  .   .  ..|| |  .  .    ||.|||.|||  ||.| .  |..  | | |.|    | . .| . ||
vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

MISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTA
  .  ...    | . ..  .|   |.|...  | .  .|  
rkefvkrniletrllelskGnethrvlhykvfGwtettlpky
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1092-1200 9.3e-18 59.0 In-house 217-348 (350) alignment 
Range on Protein: 1092-1200
Range on HMM: 217-348/350.0
VMHFNYTAWPDHGvpTANAAESILQFVH---------MV-RQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHI------RDH--------EFVD-ILG
|.....  |.| .  . .  ||||| .          .      ..   |...|||||||||||...|| ||...      ...        .  | |  
vyqlqvknWkDls..lllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

LVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
.| |.|. |.||||. .|.|||..... ..  .|
ivnelrkqrismvqnldqfifiYeallfyfaLrk
subfamily_CG42327_pd Subfamily CG42327 1122-1193 1.5e-16 55.0 In-house 240-312 (319) alignment 
Range on Protein: 1122-1193
Range on HMM: 240-312/319.0
RQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDH-EFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
|    .|.||...||| ||||||. || |  .... .  . |||  ||| .|  | | |.| ||| ||.. ..
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 972-1105 1.4e-15 51.7 In-house 3-126 (130) alignment 
Range on Protein: 972-1105
Range on HMM: 3-126/130.0
LPYDFSRVRlvsmneeeGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKrrvkcDHYWPFTeEPIA--YGDITVEMIS
|....||..        | .||||...   .  .||. || || .|  |||||.|..   ..|.|   .|.     | ||| . ||.     ||.| .  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds.ePlewyeediivtltd

EEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGV
 .| .     ...|.    .  | .  |. . ||  | 
rdefknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1132-1191 3.1e-15 50.3 In-house 1-60 (69) alignment 
Range on Protein: 1132-1191
Range on HMM: 1-60/69.0
MIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQC
|..|||.| ||||||||.   .  |.   .|||.  |  ||  |  ||  | .|||||  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1133-1191 2.2e-14 47.5 In-house 1-59 (69) alignment 
Range on Protein: 1133-1191
Range on HMM: 1-59/69.0
IIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQC
..|||.| ||||||||.   .  |.   .|||.  |  ||  |  ||  |..|.|||. 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1000-1101 3.3e-14 47.1 In-house 231-329 (440) alignment 
Range on Protein: 1000-1101
Range on HMM: 231-329/440.0
GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKrrvKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTA
||   . .|||| ||  |  |||..| . .   |.|| | |.|    |  |||     ...| .||     |. .    | . ..| .|....  |.  .
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqt

WP
||
wp
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 917-1012 4.4e-12 40.0 In-house 4-95 (95) alignment 
Range on Protein: 917-1012
Range on HMM: 4-95/95.0
PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGlDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEeegADYINANYIPGYNSPQEYIATQG
|...  | ... .|  .|| .|  .|  . .     |. .     |  |||. ||.||| .|| | .  .   .||||| .. ||   . |||.||
pihvsvfhshvlemhsnsdqefdnefksismts.gapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1005-1105 7.5e-11 36.1 In-house 137-235 (244) alignment 
Range on Protein: 1005-1105
Range on HMM: 137-235/244.0
QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKrrvkcDHYWPFTEePIA-Y-GDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAW
 ||| || || .|  |||||.|... ...|.|   .|.     | ||| .| |.  |  |||| .   .|  .  .  . |.    .  | .  |. . |
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse.plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnw

PDHGV
|  | 
psdgt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 916-1003 9.3e-11 35.7 In-house 4-88 (440) alignment 
Range on Protein: 916-1003
Range on HMM: 4-88/440.0
NPVQLDDFDAYIKDMAKDSDYKFSLqfeELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNS
 |. . ||  |...  .   ..       |   ||  |   | || |. |||| ||| ||.||| |  ..    .||||| || | .|
rpiivadfadyvqnnrrsrafedew...sllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_PTPDC1_pd Subfamily PTPDC1 1090-1198 1.3e-10 36.0 In-house 81-178 (182) alignment 
Range on Protein: 1090-1198
Range on HMM: 81-178/182.0
QDVMHFNYtAWPDHGVPTAnaaESILQFVHMVRQQATksKGPMIIHCSAGVGRTGTFIALdrLLQHIRDhefVDILGLVSEMRSYRMSMVQTEEQYIFIH
|.....|. .|.|.||..    |.||. | .| .  .  .| . .|| || ||||  ||    | . ..   ..    .. .|| | . .|| ||  ...
qgiyvynf.gwkDygvasl...eriLdivkvvafalq..egkvavhChaGlGrtGvliac..ylvyakr...ltaekaiklvrskrpksiqtreqvelvk

QCVQLMWMK
.  ...  .
efalflipl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1124-1192 1.9e-10 34.6 In-house 260-340 (349) alignment 
Range on Protein: 1124-1192
Range on HMM: 260-340/349.0
QATKSKGPMIIHCSAGVGRTGTFIALDRLLQ--HIRDHEFVD----------ILGLVSEMRSYRMSMVQTEEQYIFIHQCV
  |.   ....||||| ||||... || ||.  .   .|..           |   | |.| .|.||||   |.|.|....
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 964-1036 3.3e-10 34.0 In-house 39-117 (347) alignment 
Range on Protein: 964-1036
Range on HMM: 39-117/347.0
CKNRYTNILPYDFSRVRLVSMNEEEG-----ADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS-QIIVML
 |||  .    | .|| |   . . .       |||| .|   |. .||| || |||.|  ||||||   |  |.. ..
sknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0038934 (Phosphotyrosine protein) phosphatases II 1093-1176 6e-10 34.6 In-house 80-160 (194) alignment 
Range on Protein: 1093-1176
Range on HMM: 80-160/194.0
MHFNYTAWPDHG-VPTANAAESILQFVHMVRQQatKSKGPMIIHCSAGVGRTGTFIAldRLLQHIRDHEFVDILGLVSEMRSYRM
...    .||.| ||. .   ..|..|. . ..  ...|   .|| ||.|||||..|  . | . ..    . ..|..|.|   .
ieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlva..aYLiyrlgmsaeeAialfrekRpgai
fn3 Fibronectin type III domain 725-800 2.3e-09 30.4 Pfam-A 2-80 (85) alignment 
Range on Protein: 725-800
Range on HMM: 2-80/85.0
PPKSLFAVNKTQTSVTLLWVEE----GVADFFEVFCQQVGSSQkTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDS
.|. | . . | ||.|| | .     |  . .|| ....|...  . .  |  ... ||.. | | | |...|.. . ..
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngag
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 964-1047 4.5e-09 30.2 In-house 36-118 (332) alignment 
Range on Protein: 964-1047
Range on HMM: 36-118/332.0
CKNRYTNILPYDFSRVRLVSMNEEegADYINANYIPGYNSPQEYIATQGPLPE-TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKC
  ||   .  .|.||| |   . .   |. ||... ||.    || .| |. . |   ||.|| ..|  .|... . .||.. |.
dmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 957-1001 5.2e-09 30.1 In-house 34-77 (244) alignment 
Range on Protein: 957-1001
Range on HMM: 34-77/244.0
ADLPLNRCKNRYTNILPYDFSRVRLVSmNEEEGADYINANYIPGY
| |  | .|||| ||||.| .|| | | ...||.|||||||| | 
avlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs
fn3 Fibronectin type III domain 435-521 9.9e-09 28.4 Pfam-A 2-85 (85) alignment 
Range on Protein: 435-521
Range on HMM: 2-85/85.0
KPQHVSVHVLSSTTALMSWTSSQeNYNSTIvSVVSLTCQKQKESQrlEKQYCTQVNSS-KPIIENLVPGAQYQVVIYLRKGPLIGPPS
.|. .||.  .||.. .||. .. . ...| .  ....... ...  |..  |  ...   ....| ||..|.. .. ..|   ||.|
aPenlsvsevtstsltlsWsppk.dgggpi.tgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 950-1044 2.5e-07 23.8 In-house 15-82 (169) alignment 
Range on Protein: 950-1044
Range on HMM: 15-82/169.0
LDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINAnyipgynspqeyiatqgplpetrndfwKMVLQQKSQIIVMLTQCNEKRR
..   | |.|  |  ||| .  |   . ||.|  . |. |.|||||                           .|. .  . .||.| ....|  
ieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknn
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 950-1044 3.2e-07 23.3 In-house 14-81 (169) alignment 
Range on Protein: 950-1044
Range on HMM: 14-81/169.0
LDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINAnyipgynspqeyiatqgplpetrndfwKMVLQQKSQIIVMLTQCNEKRR
..   | |.|  |  ||| .  |   . ||.|  . |. |.|||||                           .|. .  . .||.| ....|  
ieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknn
subfamily_CDC14_pd Subfamily CDC14 1116-1197 8.7e-07 23.1 In-house 254-325 (328) alignment 
Range on Protein: 1116-1197
Range on HMM: 254-325/328.0
QFVHMVRQQatksKGPMIIHCSAGVGRTGTFIALdRLLQHIRdheFvDILGLVSEMRSYRMSMVQTEEQyIFIHQCVQLMWM
.|.... .     .| ...|| ||.|||||.||   |..| |   |      .. .|  |  .| .  |  |. .  . .|.
kfleiaeka....eGaiavhCkaGLGrtGtLiac.ylmkhyr...f.taaeaiawlricrPGsvigpqq.kfleekqaalwl
PTEN_1 1088-1172 9.8e-07 23.8 In-house 88-171 (196) alignment 
Range on Protein: 1088-1172
Range on HMM: 88-171/196.0
EMQDVMHFN--YTAWPDHGVPTANAAESILQFVHMVRQQATKsKGPMIIHCSAGVGRTGTFIAldRLLQHIRDHEFVDILGLVSEMR
|.   ....     ..|||.|. .    |.  ..  .... . ..  ..|| ||.||.|| .|   .| . .   . . | || |.|
eeffksgveylhfpieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva..ayLmykgkltadeAlelvrekR
fn3 Fibronectin type III domain 539-612 8.8e-06 19.0 Pfam-A 9-77 (85) alignment 
Range on Protein: 539-612
Range on HMM: 9-77/85.0
YPLGPTAVVLSWTRPY--LGVFRKYVVEMfyfnpATM--TSewttyYEIAATVSLTA-SVRIANLLPAWYYNFRVTMVT
 . ..| ..|||. |    | . .| ||      ...  ..     ..   ||. |. || . .| |   |.|||. |.
sevtstsltlsWsppkdgggpitgYevey.....rekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavn
DSPc Dual specificity phosphatase, catalytic domain 1089-1148 9.5e-06 20.5 Pfam-A 29-92 (133) alignment 
Range on Protein: 1089-1148
Range on HMM: 29-92/133.0
MQD-----VMHFNYTAWPDHGVPTANAAESILQFVHMVRqQATKSKGPMIIHCSAGVGRTGTFIA
..        ...|.  | .   ... .. . . | ... .|.....  ..|| ||. |..|.|.
vpnnnaikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 1089-1148 9.5e-06 20.5 In-house 29-92 (133) alignment 
Range on Protein: 1089-1148
Range on HMM: 29-92/133.0
MQD-----VMHFNYTAWPDHGVPTANAAESILQFVHMVRqQATKSKGPMIIHCSAGVGRTGTFIA
..        ...|.  | .   ... .. . . | ... .|.....  ..|| ||. |..|.|.
vpnnnaikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatlii