Gene PTPRQ in Homo sapiens

Synonym: DFNB84, DFNB84A, PTPGMC1, R-PTP-Q, PTPRQ

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP094_AA protein Get Run
HsapP094_AA_1985-2261 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 1979-2266 1.4e-126 416.5 In-house 3-291 (293) alignment 
Range on Protein: 1979-2266
Range on HMM: 3-291/293.0
SIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGP
. |||....| .||........|.|.||..|| .. .| . . |.|..||||||. || ||...|||| | .. .|||||||.||.|| .|.||||||||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVtVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPL
||.|| ||||||||......|||||..|||...|..|||.|..|| ..||| .| ..|... ||.||.||||.. ....|||..||.||.|||||....|
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

IHFVKLVRASR--AHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSN
..||. || .   .....|..|||||||||||.|||||.|.|.|...|.|||.|.|||||.||...||. .||||.|||.||||..| ..
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeee
subfamily_PTPRD_pd Subfamily PTPRD 1981-2284 2.3e-106 351.7 In-house 3-304 (564) alignment 
Range on Protein: 1981-2284
Range on HMM: 3-304/564.0
KPISKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLP
|||. ... .||..| .|..|||.||. .. .  |  . . |. | |.||||. || .|...||.| .   ..||||||||.| ||  ....|||||||.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

GTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPL
 |. |||||||| . .| ||||.. |||. .||.||||..   . .|....|   |    | .||..|.  ... . ..||| .||.||.|||||. ..|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg..tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

IHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNkgSNQPICFVNY-SAL
..... |||.. .|. |..|||||||||||.||..| . . |.. . ||||. |..||..|  |||.  ||||.|. ||. |.    |. .   |. ..|
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac..gntevesenlkqhl

QKMDSLD
||. . .
qkLaeve
0051299 (Phosphotyrosine protein) phosphatases II 1982-2260 9.9e-99 325.7 In-house 4-286 (288) alignment 
Range on Protein: 1982-2260
Range on HMM: 4-286/288.0
PISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG
.|| ...|..|..|. |.. ...||| ||...| ||. . | || |. |||...| ||...||||    .|.||||||||||.|| ....|||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE------RHGDCMTVRQCNFTAWPEHGVPENS
||.|||||||| . .. ||||...|.||. |.||||.  . ....|||..| | |.|. |.|.| |...       .| . ||..  .|.||.||||.. 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

APLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
 .|..|..||| ..|..  |..|||||||||||.|||||.| .... .  ||....|. ||. |..|||.. ||.|.....|..|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1976-2263 4.2e-97 320.5 In-house 19-302 (308) alignment 
Range on Protein: 1976-2263
Range on HMM: 19-302/308.0
YRKSIKPISKKSFLQHVEElcTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiadaSvPGSDYINASYISGY--LCPNEFI
. .| ...| ...|...|.   ... ...||| ||...  .|. . | || |. |||...| || ..||||    . .|||||||||..||   .|..||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfI

ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNK-PVTVFGDIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHG
|||||||.||.|||||||| . .. ||||...|.||. |.||||.. .  ....|....| | |.|. |.|.| |...    |.  ||..  .|.||.||
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhg

VPENSAPLIHFVKLVRASRahDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
||.. ..|..|..||| |.  .  |..|||||||||||.|||||.| .... .  ||....|. ||. |..|||.. ||.||....|..|..|
vPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0040438 (Phosphotyrosine protein) phosphatases II 1986-2266 4.3e-94 310.6 In-house 3-282 (317) alignment 
Range on Protein: 1986-2266
Range on HMM: 3-282/317.0
KSFLQHVEELCTNNNLKFQEEFSELPKFLQDlSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGD
...|.... |. ... ...||| .|...  | . . | || |. |||.|.| || ..||||  . ....||||||||..|. ....|||||||||.||.|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVK
||||||| . ...||||...|.||. |.||||.  . ....||...| | |..  ..|.| |..|  ..... ||..  .|.||.||||..  .|..|..
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

LVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSN
.||...... .|..|||||||||||.|||.. . .... . .||..  |.|||. |...||...||.||....|..| .|.  
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1988-2265 5.7e-93 306.1 In-house 8-284 (288) alignment 
Range on Protein: 1988-2265
Range on HMM: 8-284/288.0
FLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFW
 ...| .   .|.  |.||.  |... .. |.| . |. |  |||..|| ||. .||||     ..|.|||||||| |.   ...|||||||. ||.|||
pvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPvTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRA
..|.|....|.||||.  |.|. .|..|||...|| . .|.. .| . .  . |.. | | .|.... ... | ...|||.|||||..|||..... |  
elvyenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkv

SRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
.   || |.||||||||||||.||||| | .... .|..|. | ||.|| .|. .||.| ||.|.....|.| ...| 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1983-2262 4.5e-92 303.5 In-house 2-282 (318) alignment 
Range on Protein: 1983-2262
Range on HMM: 2-282/318.0
ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGT
|| . . .||..| .. .|...||. .| .  .  .|...  | |.||||. || .|.. ||||   ....|||||||.|| ||   ...||.|.||| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIH
. ||||||||  ....|||||. |.|....|.|||...   . .|..|..   |    |...| .|..|..  .  .||| ..|.||..||||..| |..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs..rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

FVKLVRASR-AHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
.|. |..    ....|..|||||||||||||||.| | ..|..   ||... | .||..|  |||   ||.|... .|. |  
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0036941 (Phosphotyrosine protein) phosphatases II 1998-2265 8.3e-92 302.9 In-house 10-282 (297) alignment 
Range on Protein: 1998-2265
Range on HMM: 10-282/297.0
NNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiadaSVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
... ....||.||...| . | . | || |. |||...| ||...||||    . .|||||||||..|| ....|||||||||.||.|||||||| . ..
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

LVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDV--QIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--
.||||...|.||. |.||||...  . ..||...| | ..|    |.|.| |...    |.  ||... .| ||.|||||. |.|..|..|||  ...  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

DTTPMIVHCSAGVGRTGVFIALDHLTQHIN---DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
. .|..|||||||||.|.|||.| . | ..    .  |||. .| .||. |...||.| ||.||....|.|| .|  
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0046845 (Phosphotyrosine protein) phosphatases II 2002-2263 1.1e-91 302.5 In-house 1-277 (284) alignment 
Range on Protein: 2002-2263
Range on HMM: 1-277/284.0
KFQEEFSELPKFLQDL--SSTDADLPWNRAKNRFPNIKPYNNNRVKLIADAS-VPGSDYINASYISGY-----LCPNEFIATQGPLPGTVGDFWRMVWET
...||| ||...  .|  | . | || |. |||...| ||...||||    . ...||||||||..||      ....|||||||||.||.|||||||| 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RAKTLVMLTQCFEKGRIRCHQYWPEDnKPVTVFGDIVITKLMEDVQIDWTIRDLKIER---HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRA
.....||||...|.||. |.||||.. . | ..||. .| | |.|. |.|.| |....    |  .||..  .|.||.||||.....|..|..||| .. 
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

--HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHD---FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
  ..  |..|||||||||||.|||||.| .... ..    ||....|. ||. |..|||.|.||.|.....|..|..|
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0047943 (Phosphotyrosine protein) phosphatases II 1998-2259 6.9e-91 299.8 In-house 9-271 (273) alignment 
Range on Protein: 1998-2259
Range on HMM: 9-271/273.0
NNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiadaSVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
... ...||| .|...  .|. . | || |. |||...| ||...||||    . .|||||||||..|| ....|||||||||.||.|||||||| ....
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

LVMLTQCFEKGRIRCHQYWPEDNKP-VTVFGDIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--D
.||||...|.||. |.||||...   ....|.. .| | |..  |.|.| |....   |.. ||..  .| ||.||||.. ..|..|..|||  ...  .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
 .|..|||||||||||.|||||.| .... .  ||.. .|. ||| |..|||.. ||.||....|..
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0043336 (Phosphotyrosine protein) phosphatases II 1982-2259 2.3e-90 298.1 In-house 1-276 (278) alignment 
Range on Protein: 1982-2259
Range on HMM: 1-276/278.0
PISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQdLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG
||| |..|....||  |.. ....|| ||..|    . . | || |. |||...| ||...||||  . ....||||||||..|| .|..|||||||||.
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPednKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLI
||.|||||||| . .|.||||...|.||. |.||||   . ....||...| | |... |.|.|.|...  ..| . ||..  ...||.|||||. ..|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

HFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
.|.| ||  .... .|..|||||||||||.||||. | ...... .||..  |.|||. |...||.. ||.||....|..
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 1979-2263 9.9e-90 296.3 In-house 10-292 (297) alignment 
Range on Protein: 1979-2263
Range on HMM: 10-292/297.0
SIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDlsSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV-PGSDYINASYISGYLC-PNEFIATQ
.  ||. . . ...  .  |.. ....|| ||...  |   . | ||.|. |||...| ||...||||    .| ..||||||||..|| . ...|||||
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRiRCHQYWPEDNKpvtVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA
||||.||.|||||||| . ...||||...|.||  |.|||||.     ..||...| | ...  ..|.| |.....|   ||..  .| ||.||||....
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsle

PLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
 |..|..|||  .|.  . .|..|||||||||||.|||.. . .... .  ||..  |.|||. |...||.. ||.||....|.||..|
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 1980-2262 5.7e-88 290.8 In-house 6-306 (307) alignment 
Range on Protein: 1980-2262
Range on HMM: 6-306/307.0
IKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQ--DLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV-PGSDYINASYI--------SGYLC
...|. . .|..| .|  ... ....|| .|...      . . | ||.|. |||...| ||...||||    .  ..||||||||.        .|| .
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

PNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE---RHGDCMTVRQCNFTA
...|||||||||.|| |||||.|| . ...||||...|.||. |.||||.. . . ..|....| | |... ..|.| |...     |   ||..  .|.
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
||.||||.. ..|..|...||. ...  . .|..|||||||||||.|||.. . ......     ||..  |..||. |...|||. ||.||....|.||
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

SN
 .
lk
DSPc_SM00195 2002-2260 1.8e-86 285.1 In-house 1-262 (263) alignment 
Range on Protein: 2002-2260
Range on HMM: 1-262/263.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
|..|||..| .  .. ..|.|. . |..|||. ||.||...||||  . . .|||||||.||.|. .....|||||||| || ||||||||.. |. |||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
|...|.|...|..||||...  ..||.| ..   .. .  ....|.|... .|  .  .|.| ....||.||||..  ....... |. |. . ..|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
||||||||||.|...| . ....... |||  .| |||..|. |||.|.||.|....||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2002-2260 1.8e-86 285.1 In-house 1-262 (263) alignment 
Range on Protein: 2002-2260
Range on HMM: 1-262/263.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
|..|||..| .  .. ..|.|. . |..|||. ||.||...||||  . . .|||||||.||.|. .....|||||||| || ||||||||.. |. |||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
|...|.|...|..||||...  ..||.| ..   .. .  ....|.|... .|  .  .|.| ....||.||||..  ....... |. |. . ..|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
||||||||||.|...| . ....... |||  .| |||..|. |||.|.||.|....||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1990-2262 2e-84 278.0 In-house 4-278 (281) alignment 
Range on Protein: 1990-2262
Range on HMM: 4-278/281.0
QHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRM
.|...| .|.|  |.||...| .  .| ..| .  . |. |||. ||  |.. |||.  . .   .|||||....||  ..|.||||||.| .. .||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpVTVFGDIVITKLMEDVQIDWTIRDLKI-ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAS
|||......||.|.  |.|...||.|||.||.  . .||...... |  .  .  | .|. ...|.  .|.| ..||||.||||.... |..| | |.  
vweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

RAHDT-TPMIVHCSAGVGRTGVFIALDHLTQHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
. ..| .|...||||||||||..|||| | .... ..  .|.  .||||| ||. ||| ..|| |... .|| |..
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1983-2261 1.9e-81 268.6 In-house 5-284 (319) alignment 
Range on Protein: 1983-2261
Range on HMM: 5-284/319.0
ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDlSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGT
|  . . .....| .. . ....|| .| .  .| . . |. . |. |||..||..|.. ||.| .   |.||||||||.| ||   ..|||||.||  |
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCM---TVRQCNFTAWPEHGVPENSAPLI
. |||||||| .. ..||||.  ||.......|||| |  ....| ...| . |. . |. ||.||.... . .   .| .  .|.||.|.|||..  |.
iedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

HFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
...| .| || . .  |..||||||||||| ||.||   ....    .|..  | .||  | .|||. .||.|... .|. ..
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0040439 (Phosphotyrosine protein) phosphatases II 2023-2261 4.8e-80 264.0 In-house 7-247 (249) alignment 
Range on Protein: 2023-2261
Range on HMM: 7-247/249.0
DLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKP
 ||.|. |||.|.| ||...||||    ....|||||||||.|| ....|||||||||.||.|||||.|| . ...||||...|.||. |.||||.  . 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

VTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQ
....||...| | ..|  |.|.| |...   .|.  ||.. ..| ||.||||.. ..|. |...||  ...  . .|..|||||||||||.|||.. . .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
... .  ||..  |..||| |...|||. ||.||....|.|| 
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPRG_pd Subfamily PTPRG 1986-2265 7.8e-80 263.7 In-house 4-292 (563) alignment 
Range on Protein: 1986-2265
Range on HMM: 4-292/563.0
KSFLQHVEELCTNNNLKFQEEFSELPK--FLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGS-DYINASYISGYLCPNEFIATQGPLPGT
| | .|| .| .... .|.||| .| .    .||  . .. | |. |||  || .|.. ||||   . . .. |||||.|| ||   ..||||||||. |
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIER-----HGD---CMTVRQCNFTAWPEHGVPEN
. |||||.|| .....||.|.  |.||  |..|||.|.  .  .| . .|   |.| .  |.| |.|.      . .     .||| ..| ||.||||| 
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkde..setygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

SAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
|.| . |||   |.. ... |..|||||||||||..|.|| |.. |.... |...|..  .|..|  .||.  ||||||. .|.... |  
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_PTPN12_pd Subfamily PTPN12 2015-2262 1.2e-79 262.2 In-house 28-279 (290) alignment 
Range on Protein: 2015-2262
Range on HMM: 28-279/290.0
QDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQ
.  |.. .. . |..|||. .| ||...||.|  . ...|||||||..| |   . |.||.||||| |. |||||.||.. . .||. . .| |...|..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIAL
|||| ..  . ||.. .|.  |.    |..|| ||.|..... .|.| ..||||.||||..  .|.....|||  . .. .|..|||||||||||. ||.
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
|.  . ....     .|.. ||.||| .| ..||   || ........|...
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPRA_pd Subfamily PTPRA 1978-2260 2.6e-79 261.5 In-house 9-295 (330) alignment 
Range on Protein: 1978-2260
Range on HMM: 9-295/330.0
KSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQG
|   |.  . . . ..   ...| .|.|||  ||    . .   |.   |. |||..|| ||. .|| |     |. |||||||.| ||   ..|||.||
kkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

PLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCM------TVRQCNFTAWPEHGV
|.  || |||||.|| .. |.||||.  |. . .|.||||..   .  .|.| ..   | | .|.|.|.. ... .| .       |||  ||.||. ||
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv

PENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
| ..  .....| |.. .   . |..||||||||||| ||.|| . . ..    ||... | .||  |  ||| . || |... .|.  
PfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0045098 (Phosphotyrosine protein) phosphatases II 2000-2262 2.8e-79 261.7 In-house 6-274 (278) alignment 
Range on Protein: 2000-2262
Range on HMM: 6-274/278.0
NLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKliadasvpgsDYINASYISGYlcPNEFIATQGPLPGTVGDFWRMVWETRAKTLV
.|... || .|.   .  . |.| .. |..|||...| ||...|||          ||||||||.||  |..||||||||| || |||||.|| . ...|
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitviv

MLTQCFEKGRIRCHQYWPEdnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE------RHGDCMTVRQCNFTAWPEHGVPENS--APLIHFVKLVRASRAH
|||...|.||. |.|||||  . . ..||...| | |.|  |.|.|.|...       .. ...|.. ... ||.||||...  ........ .|. ...
mltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------DTTPMIVHCSAGVGRTGVFIALDHLTQHIndHDFVDIYGLVAELRSERMC-MVQNLAQYIFLHQCILDLLSN
             . .|..|||||||||||...|.. . ...  .. ||..  |.|||| |.. .|||| ||.||....|.||..
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1981-2263 1.3e-78 259.3 In-house 2-286 (305) alignment 
Range on Protein: 1981-2263
Range on HMM: 2-286/305.0
KPISKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDADlPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLP
|.|. ... ....|  .... ...... .|..  ..    . .   |.||||. .| .....|..| .. |.. ||||||||. ||   ...|..||||.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

GTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIER---HGDCMTVRQCNFTAWPEHGVPENSAP
 || ||||...|.. .|.||||.  | |. .|.|||||  . .. ||.....   |    |...|.|||       .  || | ..| ||.||||. .. 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LIHFVKLVRASRAHDTT-PMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
|....| |. .. .|   |..|||||||||||||||.|   ....  . ||..... .|||.|| |||.|.|| |||. . .|.   
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
0042113 (Phosphotyrosine protein) phosphatases II 2024-2261 4.8e-78 257.2 In-house 6-244 (245) alignment 
Range on Protein: 2024-2261
Range on HMM: 6-244/245.0
LPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKPV
||.|. |||...| ||...||||  | . ..||||||||..|| ... |||||||||.||.|||||.|| . .|.||||...|.||. |.||||.  . .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

TVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRA-HDTTPMIVHCSAGVGRTGVFIALDHLTQHI
...||...| | |..  |.|.| |...  ...   .|..  .. ||.||||.... |. |...||  .| .. .|..|||||||||||.|||.. . ...
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
. .  |...  |.|||| |...||.. ||.||....|.||.
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
Y_phosphatase Protein-tyrosine phosphatase 2027-2257 6.8e-78 256.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 2027-2257
Range on HMM: 1-234/235.0
NRAKNRFPNIKPYNNNRVKLiadASVPG-SDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
|. |||...| ||...||||    . .| ||||||.|..||  ...||||||||. |..|||||||. . |..||||.. ||||  |.|||||...  . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDIVITKL--MEDVQIDWTIRDLKIERHGDCM---TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI
.||| ..     .. . ..|.|.|... ...     .|.|  .|.||.|||||.. .|..... |. |......|..|||||||||||.|.||| | ...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
.... ||.. .| |||..|. |||.|.|||||...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2027-2257 6.8e-78 256.7 In-house 1-234 (235) alignment 
Range on Protein: 2027-2257
Range on HMM: 1-234/235.0
NRAKNRFPNIKPYNNNRVKLiadASVPG-SDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
|. |||...| ||...||||    . .| ||||||.|..||  ...||||||||. |..|||||||. . |..||||.. ||||  |.|||||...  . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDIVITKL--MEDVQIDWTIRDLKIERHGDCM---TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI
.||| ..     .. . ..|.|.|... ...     .|.|  .|.||.|||||.. .|..... |. |......|..|||||||||||.|.||| | ...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
.... ||.. .| |||..|. |||.|.|||||...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Ptp69D_pd Subfamily Ptp69D 1989-2262 1.4e-76 252.5 In-house 10-288 (307) alignment 
Range on Protein: 1989-2262
Range on HMM: 10-288/307.0
LQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWR
 . ..    . .  ...|. .|..   |.|.. ..   |  |||...||.....||||        |||||||.| ||   ..||| |.|. .|.|||||
eealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWR

MVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnkPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCM-------TVRQCNFTAWPEHGVPENSAPLIHF
|..|   ...|||..  || | .|..|||..    . .|||...   |. . |..||.|.. . ...         | | ..|.|..  ||| .  |...
miaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

VKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
.. ||    .. .|..|||||||||.|.|.||| | |...  | |||.  | .|||.|  .||.|.||.||.. .||  | 
ieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2001-2264 2.3e-75 248.3 In-house 19-281 (315) alignment 
Range on Protein: 2001-2264
Range on HMM: 19-281/315.0
LKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM
  | ||| .||   .    . |  . |  |||. || |....||||      | ||||||||| .. . . .||.||||. .| ||||||..... |.||
alfseefhdlpdP.diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHC
.|.  |  .|.| ||||. .   . || | .. |  . . | ..| | . .  .  || | .|| ||..||..... |....| |.|.. ... ...|||
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc

SAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKG
|||||||||.|..|.  ..|.. . ||.. .| .||..|. .||   .| |... .|. |  . 
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2002-2271 3.6e-75 248.0 In-house 19-287 (515) alignment 
Range on Protein: 2002-2271
Range on HMM: 19-287/515.0
KFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
 | ||| .||   .    | |.   |  |||. || ||...||||      | |||.||||| .. . . .||.|||.. .| ||||.|.. .  |..|.
lfseefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCS
|.  |  .|.| .|||.       || | .  .  .   . ..| |.. .  |. || | .|| ||..|||...  |. ..| |.|.. . | |.|.|||
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcs

AGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICF
||||||||.|..|    |... . ||.. .|  .| .|. .||   || |... .|. |  . .  |.  
aGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvih
subfamily_PTPRK_pd Subfamily PTPRK 1986-2277 7.3e-75 246.7 In-house 7-296 (314) alignment 
Range on Protein: 1986-2277
Range on HMM: 7-296/314.0
KSFLQHVEELCTNNNLKFQEEFSELPKFlqdLSSTDADLpwNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGD
.  ||..  | ....  |.||.  |..      ..  |   ||.|||. .| .|.. ||.||.    | ||||||..| .|  |..||.|||||. || |
adllqsiallkraegygfkeeyeslfeg...wdaakkde..nreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkd

FWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPvtvFGDIVITKLMEDVQIDWTIRDLKIER----HGDCMTVRQCNFTAWPEHGVPENSAPLIHF
|||.|.. .. ..||||.  |.||..| .||||| .    .||| .. .  ... .  .| ...|.    . .  .||| .|..||.|.|| .   |...
fWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllkl

VKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVN--YSAL
|. | .|....  ...|||||| ||||.|||.| . . |. .. ||..  | .|||... ||.   ||.|... ||.      .  |.. ..  |   
vrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1997-2261 7.5e-74 243.9 In-house 30-294 (319) alignment 
Range on Protein: 1997-2261
Range on HMM: 30-294/319.0
TNNNLKFQEEFSELPKFLQDLS-STDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRA
 ..  |.. ||  ..|   .|.  | |.|. |. |||. || ....|.|||     . .|||||||...||  .. .||.||||. |. |||||.|| ..
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

KTLVMLTqcfekgRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQidWTIRDLKIERH---GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRA
 |.|.||      . .| |||| . .     ... .. . |  .  ...||... ..    |   ..|  |  ||..|||. ...|. .|| ||   |. 
stivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD--LLS
.. ....||||||||||||.|.|| | . ... . ||.| .| .|| .|  .||.|.|| |..  .|.  |..
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1993-2261 3.5e-73 241.5 In-house 19-291 (298) alignment 
Range on Protein: 1993-2261
Range on HMM: 19-291/298.0
EELCTNNNLKFQEEFSELPKFLQ---DLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRM
.   ...  ....|| .| .  .   . ... |  | |. |||...| ...  || | .. .   |||||||....|   | |||||.||. || |||||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrm

VWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRA
|.|  ..|.||||.  |......|.|||...|  . .|.| .. | .... | ..| ||....   .  .||| .|| ||..|||||.  ...... |||
vteedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra

SRAHDT-TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
|. .   .|.||.|||||||.| |||.| . ....    ||..  |  || .|. .||  .||.|... .|. |.
sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
0037934 (Phosphotyrosine protein) phosphatases II 2021-2259 4e-72 238.0 In-house 4-241 (243) alignment 
Range on Protein: 2021-2259
Range on HMM: 4-241/243.0
DADLPWNRAKNRFPNIKPYNNNRVKLiadasvPGSDYINASYISGYlcPNeFIATQGPLPGTVGD----FWRMVWETRAKTLVMLTQCFEKGRIRCHQYW
 | ||.|. |||...| ||...||||      .|||||||..| ..  |. .||||||||.|| |    ||||.|| . ...||||...|.||. |.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PedNKPvtVFGDIVITKLMEDVQIDWTIRDLKIER---HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAS--------RAHDTTPMIVHCSAGVG
|  ..   ..||...| | | .  |.|.| |..|.    . . .|..  ...||.||||.. ..|. |.. ||.          ...  |..||||||||
p..gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGVFIALDHLTQHIndhDfVDIYGLVAELRSERMC-MVQNLAQYIFLHQCILDL
|||..||.. . ...   . ||..  |..||. |.. .||.. ||.||....| |
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2018-2261 5.3e-72 237.7 In-house 16-258 (284) alignment 
Range on Protein: 2018-2261
Range on HMM: 16-258/284.0
SSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTqcfekgRIRCHQYWP
  | |.|. |. |||. .| ....|.|||     . .|||||||.|.||  .. .|||||||. |. |||||.|| .. |.|.||      . .| ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

EDNKPVTVFGDIVITKLMEDVQidWTIRDLKIERH---GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIA
 . .     ... .. . |  .  ...||... ..    |  ..||  |  ||..|||. ...|. .|| ||   |. .. ....||||||||||||.|.
lkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

LDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD--LLS
|| | . ... . ||.| .| .|| .|  .||.|.|| |..  .|.  |..
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_PTPN6_pd Subfamily PTPN6 1997-2262 1.3e-71 236.1 In-house 22-299 (306) alignment 
Range on Protein: 1997-2262
Range on HMM: 22-299/306.0
TNNNLKFQEEFSELPKF--LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIaDASVPGSDYINASYISGYLC--PNEFIATQGPLPGTVGDFWRMVWE
. ..  |.||| || .    . || .... | |. |||. || |....||.|  . ||||||||||.||.. .    ...||||| |. || |||||||.
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

TRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTvFGDIVITKLMEDVQIDWTIRDLKIE---RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASR
  .. .||.|.  |.|. .| .|||. ..  . .|.| .|.. |. . |...|.|...   ..... .|.| .|..||.||||..   ...|.. |.. .
ensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

AHD----TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
 .     . |..||||||.|||| || .| |.. |. . .   .||. ||  .|. |  .||  .|| |... |   . .
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN3_pd Subfamily PTPN3 2005-2260 1.2e-70 232.6 In-house 19-275 (280) alignment 
Range on Protein: 2005-2260
Range on HMM: 19-275/280.0
EEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASvpgsDYINASYIS----GYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM
 .| .| .  ..|. . | .| | .|||. .| ||.. |||| .  .    |||||.|..    .    | .|||||||. |. |||.|||| .....||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LTQCFEKGRIRCHQYWPEdNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
||.  |.||..||||||| ..  . .|.. ..   || .  . .|.| ....   .  .. |  ..|||.||||..|| ...||. ||. |. ...|..|
lttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
|||||.|||||.|.|.   . |. .. | .  .| ..|  |...||. .|| |. ..|| . 
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2025-2261 1.1e-69 229.5 In-house 7-243 (250) alignment 
Range on Protein: 2025-2261
Range on HMM: 7-243/250.0
PWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIrCHQYWPEDNKpvT
| |. |||. .| .... || |  . .   |||||||.. ||   . ||||||||. |. ||||||.|  ..|.||||.  |...  .||||| ..   .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka..e

VFGDIVITKLMEDVQIDWTIRDLKIERHGDCMT--VRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHIN
 .||. .. | ...  |.|.| ||. ..       ||| .|..||. ||||.    ....| |.||. . ...|.||.|||||||.| |||.| . ....
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
    ||.. ..  || .|. .|. |.||.|... ||  | 
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2001-2258 3.4e-67 221.4 In-house 5-266 (274) alignment 
Range on Protein: 2001-2258
Range on HMM: 5-266/274.0
LKFQEEFSELPKFLqdlSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV-PGSDYINASYISGYLC-PNEFIATQGPLPGTVGDFWRMVWETRAKTL
 ....|| |||      .  . |.. .  |||. .| | .| || | .. |  . |.|||| || ||    . ..||||||| || |||||....... .
kdlekeflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMLTQCFEKGRIRCHQYWPEDNKP--VTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDT---
||||.  |. . .|..|.|....      .||. |.      . |...| | ..   .. .|    .|.||.| .|..  .|...|. |. || ...   
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakl

TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
.|..||||||.||||.||| .   ...... .||. ..|..|| .|  |||.  || ..|. .  
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN13_pd Subfamily PTPN13 2004-2261 7.2e-67 220.5 In-house 14-270 (273) alignment 
Range on Protein: 2004-2261
Range on HMM: 14-270/273.0
QEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASvpgsdYINASYISGYLCPNEF--IATQGPLPGTVGDFWRMVWETRAKTLVML
.||| || ..   .... .    |..|||. |. ||.. |||| ....     |||||.|   .  .|.  ||.||||| || |||.|||| .|. ..|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQCFEKGRIRCHQYWPED-NKPVTVFGDIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAhDTTPMIV
|.  |||...||.||||  ||...| . . ...|    . ....|.|...    |.   | . ||..||.|||| ..|.|..||. ||  .  |..|..|
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
|||||.||.|..|..| . . |.    .|.  .| .||  |  .||   |||| .. ||..|.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2024-2261 8.6e-67 220.3 In-house 46-280 (315) alignment 
Range on Protein: 2024-2261
Range on HMM: 46-280/315.0
LPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnkpV
   |. |||. || .|.. ||.|      |.|||.||..| ||  .. .||.|||.. .|.||||.|.|    ..||||.  |. . .. .|||..    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...k

TVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
 ..| | .|.  |.|. ..|.| | .    .  .| | ..|.||. |||. . ||..... |.  .  . ....||||||||||| ||.|| . ....  
viyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeae

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
. .|.| ..  .|. |. ||| ..|| |... .|. . 
naidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_PTPN9_pd Subfamily PTPN9 2019-2259 2.9e-66 218.5 In-house 34-289 (297) alignment 
Range on Protein: 2019-2259
Range on HMM: 34-289/297.0
STDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPE
 . . |. |  |||. ..  |.. ||.|      . ||||||... ||  .. ||||||||. || |||||||| .. ..|| |.. |.||..| ||||.
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

DNKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH-------------DTTPMIVHCSAG
... .. |||. ....  ... |...| |.|.  ....  .|    |..||..|||...| |..... ||  .|              .  |..||||||
eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaG

VGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
.|||| ||.||   ..... . ||.   |  ||. |  ..|   || | ....|. 
iGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1987-2282 5.3e-63 208.1 In-house 9-312 (325) alignment 
Range on Protein: 1987-2282
Range on HMM: 9-312/325.0
SFLQHVEELCTNNNLKFQEEFSELPKfLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDF
 ...|||.  ....  |  ||  ||   .  . . | .| |.|||||.|. .....|| | .    | ||||||||.  .   . |.|.| ||. |..|.
nlvehvekkkaqdqdgfahefgllps.ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WRMVWETRaKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVIT-KLMEDVqIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVK
||.| . |  ..|...  ...|  || .|||..      || . .  . .|..  |.  | |..   ..|. ..|.| .. .|.. ||..  | || ...
WrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilq

LVRASR------AHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFV--NYS
|| |        .. .||..||||||||||||||.|  . ... ..  |||.| |  || .|  ||.   |||...... . . .  .. |.. .  . |
lvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakls

ALQKMDS
.||. . 
slqernp
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1982-2265 9.5e-63 207.1 In-house 9-289 (297) alignment 
Range on Protein: 1982-2265
Range on HMM: 9-289/297.0
PISKKSFLQHVEElcTNNNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCpnEFIATQGPLPG
||    |   |..    .   |.|||  ||.  .  ..| |.   |  |.|. || ||. .||||    . | |||.|||.. |.    ..|.|| | . 
piplsdfatlvqk..nrhtdvfseeflclpea.niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TVGDFWRMVWETRAKTLVMLTQCFEKGRiRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPE--NSAP
|| |||.||.. ...|.|||..  |. . .| .||...   || |||.... |  . .     |.|....        |.| .|. ||.. |..  . . 
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LIHFVKLVRASRAHDTT-PMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
|..... || .  . .  |..|||.||||||||....|    ...... |||.|||  || ||. .||   || |... .|. |. .  
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1986-2261 4.6e-62 204.5 In-house 5-284 (290) alignment 
Range on Protein: 1986-2261
Range on HMM: 5-284/290.0
KSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV--PGSDYINASYISGYLCPNEFIATQGPLPGTV
. | ..|..  ...| .|...|  | .. .. . | .  . |. .||| || .|..||. |   ..      .||||.|| ||   ...||||||.. |.
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

GDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnkPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG---DCMTVRQCNFTAWPEHG-VPENSAPLI
 |||...|. .   .||||.  |.|. .|.||||.   ... .| . |. | | .  . ..| |... .    .. .| | ..|.|...| |..... |.
vdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

HFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
 . . ..  | .  |...||||..|||..||.|..   .. .    .|.. .. ..|. .. .||   || ...| .|  |.
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2025-2258 1.4e-61 202.8 In-house 18-262 (270) alignment 
Range on Protein: 2025-2258
Range on HMM: 18-262/270.0
PWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLC-PNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKP-
  ... ||. .| |  . ||.|    . . . |||| |. |.   ....||..|||| |. .||||.||......||.|.  |||| .| .|||...|  
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-VTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA------PLIHFVKLVRASRAHD--TTPMIVHCSAGVGRTGVFIAL
  . .|.| ...| |  .  . .. |..|..|.   .    ...||.||||...        |.. .. ||.|. .   ..|..|||||||||||..|||
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
|. .. .. .  ||.  ...||| .|| .||   || ||.. .. 
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1988-2261 1.1e-60 200.0 In-house 7-279 (287) alignment 
Range on Protein: 1988-2261
Range on HMM: 7-279/287.0
FLQHVEELCTNNNLKFQEEFSELPKFLQDL-SSTDADLPWNRAKNRFPNIKPYNNNRVKLIadasVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDF
| . |..   ..|  |.. |  | .  |.  . | .  . |. |||. .| ...|.|| |         |||||..| ||   ..||....|.  |. .|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERH---GDCMTVRQCNFTAWPEHG-VPENSAPLIHFV
|..... . ...|||.|  |. .  |.|||||..   .|.|.  |. | |.|. ....|.|.....   ||  .|.| ..|.|...| |.|  . |. . 
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

KLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
. ... | .  |...||||..|||...|.| .   .. .    .|.. .. . |  .. .||  .||.|. . .|  |.
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2027-2258 2.9e-59 195.2 In-house 3-237 (237) alignment 
Range on Protein: 2027-2258
Range on HMM: 3-237/237.0
NRAKNRFPNIKPYNNNRVKLIADASVpgSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTv
|..|||. ||. |. .|| |    |   ||||||.|. |.   |...||.||||  .  |||.|||. .   .||||   |. ...||.|||. ..| . 
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa.

FGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVR---QCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHI
.| . ..   ..   |.|.| | . ...    ||   | .||.||..|||...| |. | | .     |  ...| |.||||||||||.|. .| . .. 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
...  ||||  |  .  .|  ..|   ||.|.|| ||.
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN14_pd Subfamily PTPN14 2002-2262 5.7e-59 194.6 In-house 24-298 (300) alignment 
Range on Protein: 2002-2262
Range on HMM: 24-298/300.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVpGSDYINASYISGYLCPN--EFIATQGPLPGTVGDFWRMVWETRAKTLV
|   |. ..||  .|   . | || |  ||||... ||..|||.|..      ..||||| |.  .. .  ..|..||||. || |||.||||.  . .|
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MLTQCFEKGRIRCHQYWPED--NKPVTVFGDI-VITKLMEDVQIdWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDT-
|||.  |.|. ....|.|..  .|    ||   |.||. || .   . . ||..    ..  ||    .| ||.|||||.  . ..... |.. | . . 
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsds.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

--------TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
         |..|||||||||||| |  | |.. ..  . .||   .| ||  || .||.|||| |... ..  | |
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_PTPN1_pd Subfamily PTPN1 2002-2258 2e-57 189.1 In-house 7-269 (290) alignment 
Range on Protein: 2002-2258
Range on HMM: 7-269/290.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASvpgsDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
...| . .. |  .|.. ..|.|| ||..||. ...||.  |.||  .      |||||| .       ..| |||||| ||. ||.|||| ..|..|||
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TQCFEKGRIRCHQYWPEDNK-PVTVFG--DIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASR--AHDTT
 .. ||..|.|.||||....    ..    . .. . |...  .|.| |..|     .. .. .  .|.||. ||||  | ...|.  || |   ..|  
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvG

PMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
| ..|||||.||.| |. .| .  .|...|    |||   . |||. |. ..|   |  | .. ||.
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN23_pd Subfamily PTPN23 2003-2258 5.3e-57 187.8 In-house 17-278 (288) alignment 
Range on Protein: 2003-2258
Range on HMM: 17-278/288.0
FQEEFSELPKF----LQDLSSTDADLpwNRAKNRFPNIKPYNNNRVKLIadasVPGSDYINASYISGY--LCPNeFIATQGPLPGTVGDFWRMVWETRAK
....| || .      .. | . | |  .  |||. .| ||..|||||         ||||||.. .    ||. |||||.||..|..|||.||.| ...
ldkkfkeleqkqdkearkrsiaiakl..yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkss

TLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGD--CMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRA----SRA
..|||..  |.|. ....|||||.   ..|||. .|   .     .  |.||.| ..     .|.  ..|.|||.|||.    |..|.. |..     . 
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
.  ||..|||||||||||||  .    . .. .   .||  .|  || .|  |||. .|. |. . .| 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1984-2259 7.8e-57 187.6 In-house 3-278 (439) alignment 
Range on Protein: 1984-2259
Range on HMM: 3-278/439.0
SKKSFLQHVEELCTNNNLKFQEEFSELPKFLQD--LSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG
... | .|||.|  |..  |.|.| ..     |    .. |   ....|||. .. ...  || |     || | |||| || ||  .. .||||||   
grdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkke

TVGDFWRMVWETRAKTLVMLTQCFEKGRirchqYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAWPEHGVPENSAP
|. ||||.|.| .. |.||||. .|  .     ||| |..  ...|||..    .    ...|| .|.  . |      || |  ..|||.. || ... 
ttddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

LIHFVKLVR-ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
...|.. .  |   ... |..|||||||||||  ||||   ....  . ||| |.|  || .|  |||.|.||.|.....|. 
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2026-2257 3.7e-56 185.0 In-house 37-274 (287) alignment 
Range on Protein: 2026-2257
Range on HMM: 37-274/287.0
WNRAKNRFPNIKPYNNNRVKLIADASvPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
 .  |||. .. |....|| | |..   ||||||| |...|   ..|||.|||.. ||.||||.|.|||. .....|.  |..| .|..|||| ..|. |
aavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

FGDIVITKLMEDVQIDWTIRDLKIER-HGD-CMTVRQCNFTAWPEHGVPENSAPLIHFVKLV----RA-SRAHDTTPMIVHCSAGVGRTGVFIALDHLTQ
 |  |.    .  . ....| |..   ..  .  |.| .. .||.....  .  || ||  |     .   | .. |..||...|.||.|...|.  | .
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
  .|   ||.   |. ||  | ..||   |. .| . . 
rledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1999-2270 1.3e-55 183.4 In-house 18-246 (392) alignment 
Range on Protein: 1999-2270
Range on HMM: 18-246/392.0
NNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTL
 .  | ||| .||   .    | |  . |  |||. || ||...||||     .| |||.||||| .. . . .||.||| . .. ||||||.. .. |.
hsalffeefhdlpgp.diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtti

VMLTQCFEKGrirchqywpednkpvtvfgdivitklmedvqidwtirdlkieRHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
.|.|.  |                                            .  |. || |  || ||...||. .. |..|.| |.|   . | |.|.
amvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythplii

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPIC
||||||||||| |..| .  | .   .||.. .|...| .|  |||   || |.. ..|. |  . .  |. 
hcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvv
0051429 (Phosphotyrosine protein) phosphatases II 2052-2261 8.4e-54 178.3 In-house 1-226 (272) alignment 
Range on Protein: 2052-2261
Range on HMM: 1-226/272.0
VPGSDYINASYISGYLC---PNEFIATQGPLPGTVGDFWRMvWETRAKTLVMLTQCFEKGRIRCHQYWP----------EDNKPVTVFGDIVITKLMEDV
.| |.||||....||     |. .....|||| |. ||||. .| . || |.|....|.||  |..|||          .|  |   .|....| |.| .
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

QIDWTIRDLKIE---RHGDCMTVRQCNFTAWPEHGVPENSapLIHFVKLVRAsrahdTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVD--------
. |...| | ..     |. ..|..  .|.|| ||||...  |.....|...       |..||||||..|||...||..| . ..... ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
... |.|||. |...||. .||.||....|.|| 
leeaveelraqrpgavqteeqylflyeallellr
subfamily_CG7180_pd Subfamily CG7180 1998-2258 2e-51 169.4 In-house 14-288 (296) alignment 
Range on Protein: 1998-2258
Range on HMM: 14-288/296.0
NNNLKFQEEFSELPKFLQDLSSTDADLpWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
. ..... |.   |.. ..   ..  .  || ||| ... ||..||| |        ||||||.|. ..| ..|.| |..|   ||..|||.|..  ...
kfrveyklelkltprleigdCagglrk.enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

LVMLTQCFEKGRiRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERH------------GDCMTVRQCNFTAWPE-HGVPENSAPLIHFVKL
.|.||. |.  .  ...|||..    . .|.|..  ..|.   . .|| .|. ..             .  .|.. ..| |.  . ||  .. ||.... 
vvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VRASRAHD-----TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
||  | .      . |..|..| |..|.||..|.|   . .. .. ||... |  || .|  .|.|  .| .. . .|.
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1997-2258 3.5e-51 168.8 In-house 5-264 (283) alignment 
Range on Protein: 1997-2258
Range on HMM: 5-264/283.0
TNNNLKFQEEFSELPKFLQDLSSTDADlpWNRAKNRFPNIKPYNNNRVKLIADASvpgsDYINASYIS---GYLCPNEFIATQGPLPGTVGDFWRMVWET
.|||  |.| . .|    .|   . ||   |. |||. .| |....||.| ...     |||||..|     |   ...|..|.||  || |||.||.. 
vnnnklfrevlkrlsvpdldadiasad..enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

RAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERH---GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRA
.. ..||||.  |  ||.| ||||..      .|.  .|   |  .  ..|. | .       . . .    .  | | |       |..| |..   . 
kitaivmltklqedlrikCsqyWPkrG..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqte

HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
.  .|..||||.|.|||.||||.    ...  .  ||..  |  .| .|| .||.| || ..|. .|.
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2027-2258 4.2e-50 165.1 In-house 7-238 (239) alignment 
Range on Protein: 2027-2258
Range on HMM: 7-238/239.0
NRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpvTV
|.||||. ||  |. .|| |   .  | ||||||||.  |   |. .||||| .  . ||||||.|. |   .||||   |  . .||||||.     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk

FGDIVITKLMEDVQIDWTIRDLKIERHGDC--MTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
. .. .|    .|  |. || . . . |.     | |  || ||..|||. .. .. . . .       . | ..|||||||||| |. .| . .. . .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
  |||.  |  .| .|  |||   ||.|.| ..|.
ktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2027-2257 5e-50 164.9 In-house 8-238 (239) alignment 
Range on Protein: 2027-2257
Range on HMM: 8-238/239.0
NRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpvTV
|.||||. ||  |. .|| |   .  | ||||||||.  |   |. .||||| .  . ||||||.|. |   .||||   |  . .||||||.     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk

FGDIVITKLMEDVQIDWTIRDLKIERHGDC--MTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
. .. .|    .|  |. || . . . |.     | |  || ||..|||. .. .. . . .       . | ..|||||||||| |. .| . .. . .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
  |||.  |  .| .|  |||   ||.|.| ..|
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1997-2261 2.9e-48 159.1 In-house 13-294 (301) alignment 
Range on Protein: 1997-2261
Range on HMM: 13-294/301.0
TNNNlkFQEEFSELPKFLQDLSSTDADlPWNRAKNRFPNIKPYNNNRVKLIADA--SVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETR
 .|.  |.|...|| .  .. ..   .   |.| ||| ||..|..||. |      ..   .|||||||.||   ..|||.|||.  |. ||||..|. .
hsnk..feeqykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

AKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLK-----------------IERHGDCMTVRQCNFTAWPEHGV-PENSA
  ..||.|.  |. . .|.||||. ..  . || . .|   | |  |..||.|.                 .... . ..| | . | ||..|| .|   
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

PLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
 |    . . . .  .  |..||||..|.|.||.....           ||.....  .|  .. .|. | ||..... |   |.
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0036282 (Phosphotyrosine protein) phosphatases II 2054-2254 3.3e-48 159.0 In-house 1-164 (174) alignment 
Range on Protein: 2054-2254
Range on HMM: 1-164/174.0
GSDYINASYISGYLCPNEFIATQGPLPgtvgdFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnkpvtvfgdivitklmedvqidwtirdlkiERHG
||||||||..... .....||.||||.     ||.|..| . .|.|||....|.|. .|..||||                                |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

DCMTVRQCNFTAWPEHGVPENSApLIHFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHINdHDFVDIYGLVAELRSERMCMVQNLAQYIFL
   .. |  .. || ||||. |  |..|||.|.  ... .  |..|||||||||||...|.. . ...  ...||.. ||.|||. |..|||.  ||.||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HQ
..
yy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2002-2259 1.9e-47 156.7 In-house 17-276 (307) alignment 
Range on Protein: 2002-2259
Range on HMM: 17-276/307.0
KFQEEFSELPKFLQDLSSTDAdLPWNRAKNRFPNIKPYNNNRVKLIADASvpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
....||..| |   .  ...| .  |  |||. ..|  ...|. .  |     |||| | |.   . |. ||..||||  |. .|| |. . . ....||
alvdefrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVIT---------KLMEDVQIdWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIhfvKLVRASRaHD
 .. | ..|.|.|||| ..    |||.   |         ||  | ..   . .||..  ... |... ... ||..|||.     |    |. | |  |
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedl.invttlkvdwaqksrtiqhlqwenwpdrgvpqinltai...nlleavr.yd

TTPMIVHCSAGVGRTGVFIALDHLTQ-HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
| |..|||||||||.|  .|.  . .  |.  .  |.  || ||||.|   .|. |||..||. .|. 
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0041856 (Phosphotyrosine protein) phosphatases II 2027-2263 3.6e-47 155.6 In-house 1-174 (182) alignment 
Range on Protein: 2027-2263
Range on HMM: 1-174/182.0
NRAKNRFPNIKPYNNNRvkliadasvpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTqcfekgrirCHQYWPEDNkpvtvf
|. |||...| ||...|          ..|||||... |.| ...||||||||..|| ||.||..| . .|.|.||         ...||||.       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdivitklmedvqidwtirdlkierhgdCMTVRQCNFTAWPEHGVPEnSAPLIHFVKLVRAsrahDTTPMIVHCSAGVGRTGVFIALDHLTQHindhdFV
                              .. |  .. || ||||.    |..|.. |..    .  | .|||||||||||...|.. . ..      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
...  |...|| |..||... ||.||....|.|| .|
sleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_PTPRN_pd Subfamily PTPRN 1989-2257 2.4e-46 152.8 In-house 18-289 (297) alignment 
Range on Protein: 1989-2257
Range on HMM: 18-289/297.0
LQHVEELCTnNNLKFQEEFSELPKFLQDLSST-DADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCP-NEFIATQGPLPGTVGDF
|...|.  . |. ....|.  | .. .. |..  |. . |  |||  .. ||...|||| ..||   ||||||| |         .|||||||. || ||
lsyledhlk.nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadf

WRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDivITKLMEDVQI-DWTIRD--LKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVK
|.||||  .  .|.||.  |.|  .|..|||.. . |  . .  .  . | .   |. .|   ||  .  .  || |  | .|||.||| .. .|..| .
wqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiye..vhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrr

LVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
 |  |    ..|..||||.|.|||||.|..| . ....     .||   .  || .|  .|.  .|. |  ... 
kvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0049772 (Phosphotyrosine protein) phosphatases II 2013-2274 6.8e-43 142.9 In-house 32-294 (314) alignment 
Range on Protein: 2013-2274
Range on HMM: 32-294/314.0
FLQDLSSTDADLPWNRAKNRFPNIKPYNnNRVKLiADASVPGSDYINASYISGYlcpNEFIATQGPLPGTVGDF----------WRMV--WETRAKTLVM
 |..|. . |||. || |||...| |.. |||.|    .| |||||||||..|.   . ||||||||. || ||          ||||  .. .  ..||
vlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LTQCFEKGrirchqywpednkP--------VTVfgdivitklmedvqidwTIRDLKIERHGDCMTVRQCnftAWPEHGV
                     |... ..|             .                            .. . .    .  ... ..    .| ...
srdevladelsrLdaAlgKtpllildgng.............neptaadlellk.................eelydpelferlgikylri...pvpDgsa

PeNSAPLIHFVKLVRASraHDTTPMIVHCSAGVGRTGVFIALDHLTQHINdHDFVDIYGLVAELRS--ERMCMVQNLAQYIFLHQCILDLLSNKGSNQPI
|  .. . .|......   .. .| .|||.||.||||.|.... |  . .  .. ...  | . |.   .. ....| ||.| ....|..|... ..  .
p.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg.vsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkfyey

CFVNY
.  |.
leenl
subfamily_ptpA1_pd Subfamily ptpA1 2002-2219 1.6e-42 140.7 In-house 22-255 (418) alignment 
Range on Protein: 2002-2219
Range on HMM: 22-255/418.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYlCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
| .|||  | . .    ... |   | .|||. || | |  ||.|       ||||||| || |   |..||.|||||| |. |||||||| |.. .|||
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivml

TQCFEKGRIRCHQYWPEDNK--P-------VTVFGDI--VITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAS--
..  |. ||.| .||||.              |||     . ....| . .   |....   |.   . | ..  ||.| .|. . |. .... .     
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

----RAHDTTPMIVHCSAGVGRTGVFIALDHLTQH
     .    |.|||||||||||| | .   . ..
qiipssdrnvpiivhcsagvgrtgtfctavimmkk
0043147 (Phosphotyrosine protein) phosphatases II 2053-2254 1.6e-41 137.2 In-house 3-155 (172) alignment 
Range on Protein: 2053-2254
Range on HMM: 3-155/172.0
PGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCfekgrirchqywpednkpvtvfgdivitklmedvqidwtirdlKIERH
.|||||||||...| .|..||||||||. |. |||||..|   ...|.||..                                              . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GDCMTVRQCNFTAWPEHGVPeNSAPLIHFVKLVRA-SRAHDTTPMIVHCSAGVGRTGVFIALDHLTqhindhD-FvDIYGLVAELRSERMCMVQNLAQYI
. . .. |  .. || |||| ... |..|.....      .  |..|||||||||||...|.. .         . ...  ||..|. |...|||  ||.
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

FLHQ
||..
flyy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2028-2260 3.3e-41 135.9 In-house 57-283 (290) alignment 
Range on Protein: 2028-2260
Range on HMM: 57-283/290.0
RAKNRFPNIKPYNNNRVklIADASVPGsDYINASYISGYLCPneFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFG
  |||. ..   .  ||  | .   .| ||. | |. |   .  || |||.|  || |.|||| .... ..||| . .|.|. .|.||.|| .  |  ||
fkknrykdvvcndktrv..ilkdGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DIVITKLMEDVQIDWTI-RDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASrahdTTPMIVHCSAGVGRTGVFIALDHLTQHINDHD
.| ..  .|| . . .| . | .     |    ..  .  .||.. |.  .  |.  .. .|      . |..||||||.|||| |.|..   | . |  
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGk

FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
 .|. .||  ||  |.  ||   ||. | . .||| 
eldlldlvralrnsrlnsvqvdiqylalveilldlG
0046846 (Phosphotyrosine protein) phosphatases II 2052-2261 4.7e-41 135.8 In-house 9-174 (176) alignment 
Range on Protein: 2052-2261
Range on HMM: 9-174/176.0
VPGSDYINASYISGYLcpneFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTvfgdivitklmedvqidwtirdlkier
 ...|||||..| |..    .||||||||.|. ||..|..| . ...|.||...|.||..|..||||  |.                             
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

hgdcmtvrQCNFTAWPEHGVPENsAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTQhindHDFVDIYGLVAELRSERM-CMVQNLAQYI
        |  .. ||.||||.  . |.......|  . ..  | .||||||.||||...|.. |      . .....  .|..|. |. ..||. .|| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyr

FLHQCILDLLS
||....| ||.
flyefellllk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2005-2264 9.5e-41 134.4 In-house 28-293 (305) alignment 
Range on Protein: 2005-2264
Range on HMM: 28-293/305.0
EEFSELPKF-----LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiADASvpGSDYINASYISGYLCPN-EFIATQGPLPGTVGDFWRMVWETRAKTL
||| .| |.      | .  ..     . .|||. ..   ... ||| .. |   |||| | |.   . |.  ||..||||  |. .|| || . . . .
eefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl.dkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqi

VMLTQCFEKGRIRCHQYWPEDN-KPVTVFGDIV-----ITKLME-DVQIDWTIRDLKIErHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRah
||| .  | |...| ||||  . . ... . ||      .| || | .|. |. .|     .. |.||. ..| ||. |||      . ..  .| |.  
vmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgsk..

dtTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKG
   |..||||||.||||  .|.... ..| .  .   .  ||  || .|   .||  ||.|.|. .|. . .| 
..vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2027-2263 1.2e-39 131.1 In-house 43-274 (288) alignment 
Range on Protein: 2027-2263
Range on HMM: 43-274/288.0
NRAKNRFPNIKPYNNNRVKLIADASVpgsdYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVF
| ...|. |.   .  ||||  |.      ||.|  .|    .. .| .| || ||.. .|.|. |.  . .|||..  |||. .  .|.|      . .
nptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDIVITKLMEDVQIDWT--IRDLKIERHGDCMT-VRQCNFTAWPEHGVPENSAPLIHFVKLVrasRAHdTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
| .      . ..|| .  .  |.|...|.    |..  .  |...|||||  . ..... .   ... . |..||.|||||||| .|      . .  .
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...ksl.qkPivvhssaGvGrtgtlililialeslrld

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
||. |  |.|.|| ||.  .|   ||...|.|.|. |  |
dflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2002-2259 2.4e-39 129.7 In-house 12-268 (281) alignment 
Range on Protein: 2002-2259
Range on HMM: 12-268/281.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIA-DASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM
 |..|||.||        |  . | |  |||. ||   .  ||.|         .||| | ||   .    .| ||||   |  |||||.|.  . ..||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIhfvKLVRASRAHDtTPMIVHC
| |  |  | .| .|.| . . .  |  . ..     |.       |..   |.   . .  .  ||.  ||| |  ..   |..|  ||.  || ..||
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevml...kilrkirars.tppvihc

SAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRS-ERMCMVQNLAQYIFLHQCILDL
||||||.| ..|..   | |  |  . ||  .|. ||   | . || | ||... . .||.
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1999-2258 2.9e-39 129.7 In-house 4-257 (267) alignment 
Range on Protein: 1999-2258
Range on HMM: 4-257/267.0
NNLKFQEEFSELPKFLQDLSSTDADLPW-NRAKNRFPNIKPYNNNRVKLIADAsvpgSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
.. ....|| .. |  .. |     ..  |...||. .  ||...|| |         .||||||. ||   | ||.||.||  |..||. .. . .  .
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

LVMLTQCFEkGRIRchQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDC-MTVRQCNFTAWpehGVPENSAPLIH--FVKLVRASRAHDTT
 |.||. |. . ||  ..||        . |... . .|  . |. |  |... . ..   |    .  |    .  |  | ..  |  | .        
ivlltkvft.dnir..lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnr

PMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
|..|.||.||||.| |. .|   . .   . .||. .. ..|| |. .|. . .||..|. . .
PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0049260 (Phosphotyrosine protein) phosphatases II 2062-2254 2e-38 126.8 In-house 1-144 (152) alignment 
Range on Protein: 2062-2254
Range on HMM: 1-144/152.0
YISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWpednkpvtvfgdivitklmedvqidwtirdlkierhgdcmtvrQC
.|.||  |.||||||||.| |. |||||..|  ..|.||||...|.|.. |.||.                                           | 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

NFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTqhindhDFVDIYGLVAELRSERMCMVQNLAQYIFLHQ
 .. || ||||..|  |. ......  . ..  | .|||||||||||...|.. .         |...  || .|. |...|.|  |..||..
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1984-2263 9.9e-38 124.6 In-house 5-290 (305) alignment 
Range on Protein: 1984-2263
Range on HMM: 5-290/305.0
SKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDA-DLPWNRAKNRFPNIKPYNNNRVKLiaDASVPgSDYINASYISGYLCPNEFIATQGPLPGT
 ||  |. |..   .    ...||. . .| .|.    |     .. |||. ..   .||||||  ... |  .|| | |.|    |. || || ||  |
qkkqilkfvkrtlekgpaglraefvamkrf.ndfekmkafkeaqeagknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplekt

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGD---IVIT--------KLMEDVQIDWTIRDLKIERHGD-CMTVRQCNFTAWPEHG
  ||| | .. . ... || .  |||  .|..|.. ..|.|  | .    ..         |. .| . . |   | ||  |     | .  .  ||. |
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPENSAPLIHFVKLVRASRahdtTPMIVHCSAGVGRTGVFIALDHLTQH-INDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
||     .. ...  |.|.     |..||||||.||||  . |... .  .. .   |   ..  .| .|   .|  |||.|.|| ||. . .|
vpaadlailellekarpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
0051082 (Phosphotyrosine protein) phosphatases II 2054-2256 7.2e-35 115.1 In-house 2-149 (151) alignment 
Range on Protein: 2054-2256
Range on HMM: 2-149/151.0
GSDYINASYISGYlcpneFIATQGPLPgtvgDFWRMVWETRAKTLVMLTQCFEKGriRCHQYWPEDNkpvtvfgdivitklmedvqidwtirdlkierhg
 |||||.||. |.     .....|||.    ||.....|   || |.|.. .| |   |..|.|| .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

dcMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAsraHDTTPMIVHCSAGVGRTGVFIALDHLTQHindhdfVDIYGLVAELRSERMCMVQNLAQYIFLH
  ..|... .. ||..|.|.. . ...|..|...   ..  |..||||||.||||...||. . ..      |...  ..|.|. |. .||   |..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

QCI
...
fal
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2027-2263 3.4e-33 109.8 In-house 35-273 (285) alignment 
Range on Protein: 2027-2263
Range on HMM: 35-273/285.0
NRAKNRFPNIKPYNNNRVKLIADAsvpgSDYINASYISGY-LCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
|   ||. ...  .. || |         ||| ||..       . .|.|||||| |. |||.|... .   ..||   || |  .|  |.||    |  
npdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

FGD--IVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTQH
||   | .|.  |.      .  | .    |     . . . .   ||..  ||.. |.| . | |.    .. .|. ||||||||||  |. .|. | .
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyatir

INDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
| .   ...  .| |.|. |.  ||.  |..||.  ... .  .
imenpniemldivremramrfqavqshmqflflyvvlmeyfige
PTPc_DSPc_SM00012 2157-2257 7.8e-33 108.2 In-house 1-104 (105) alignment 
Range on Protein: 2157-2257
Range on HMM: 1-104/105.0
TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHD--TTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLH
||..  .|.||.|||||.| ....... |. .. .   ..|..|||||||||||.|.||| | |..... ..|||. .| |||..|. |||...||.||.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QCIL
...|
rall
0044763 (Phosphotyrosine protein) phosphatases II 2038-2262 7.9e-33 108.9 In-house 1-173 (178) alignment 
Range on Protein: 2038-2262
Range on HMM: 1-173/178.0
PYNNNRVKLIADASVPGSDYINASYISGYlcpnEFIATQGPlpgtvGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvtvfgdivitklmed
|. ..||.|.    ...|||||||.| ..     ......|      |......|   ...|.||. .| |.. |..||||..                 
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vqidwtirdlkierhgdcmtvRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHindhdFVDIYGLVAELRS
                      |  .. .| ||||. .. .  ||..... .. .  | .|||||||||.|...|.. . ..      ....  ....|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

ERMcMVQNLAQYIFLHQCILDLLSN
 |. .|.|  |. .|... | ||..
rRp.ivpnpgqlrqLyefelrllke
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2016-2257 8.1e-33 108.3 In-house 41-287 (310) alignment 
Range on Protein: 2016-2257
Range on HMM: 41-287/310.0
DLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPgSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQY
| | |      .  |||. ..   .. ||||  | |    ||| | |.      . || .||||  |. |||||... ||.....| .  |.|| .|  |
dssltyeaykkymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPEDNKpVTVFGDIVITKLMEDVQiDWTIRDLKIERHGDCMT------------VRQCNFTAWPEHGVPENSAPLIHFvKLVRASRaHdtTPMIVHCSAG
||        .| | .|.| |  . .. | .| .    | .             |   ..  ||. |||..    .   .|.   | |   | .||||||
wpslgv.tetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rllaqvr.h..gpcvvhcsag

VGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
..|..| .||.   ....  . ||.  ...||. .|.  .|.  ||.....  .
kdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2029-2181 2.3e-31 103.8 In-house 35-189 (297) alignment 
Range on Protein: 2029-2181
Range on HMM: 35-189/297.0
AKNRFPNIKPYNNNRVKLIAdaSVPGSDYINASYISGY--LCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVF
 |||. .|  ....||||    .....||||| |.       .  .| .||||  || |||..|.|   ...||...  | || .|  |||. ..     
rknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

GDIVITKLMED--VQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHF
||.|.  | .         . .|..    .   || ..| .||.|||| .   |  |
gdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2028-2252 3.5e-31 103.1 In-house 51-273 (301) alignment 
Range on Protein: 2028-2252
Range on HMM: 51-273/301.0
RAKNRFPNIKPYNNNRVKLIADAS-VPgsdyINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVF
. |.|.|..    .  |..|.|   ||    | | .|.    |. ||||||||. |  ||| |.     ...|||.|  ||   .|..| | . .     
kdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GDIVITKLMEDVQI--DWTIRDLKIERHG---DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRahdtTPMIVHCSAGVGRTGVFIALDHLTQHIN
|   |.   ... .  . . | |..|      .  ||   ... |...|||.  | | ....||. |.     |..||||||.||.  ||. . |.....
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareve

DHDFVDIYGLVAELRSERMCMVQNLAQYIFL
 .  ...   ...|| .| . ||.  |  ..
adptieltealkhlrehrwngvqtnsqlywm
subfamily_CG42327_pd Subfamily CG42327 2004-2188 3.5e-27 89.9 In-house 8-193 (319) alignment 
Range on Protein: 2004-2188
Range on HMM: 8-193/319.0
QEEFSELPkflQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLT
 ||| .||   | ....|.  .  . |.|. |. |  . || |   .. . . |..|||. ||  .|| .||.| .|  .  ||||.||| .....| ||
aeefrdlP...qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

QCFEKGRIRCHQYWPEDN--KPVTVFGDIVITKLMEDVQIDWTIRDLKIERH--GDCMTVRQCNFtAWPEHGVPENSAPLIHFVKLVRAS
. .|.|  .| .|.|  .  .   ..||| .|    .|.  . |  | . |     .  .    .  |.| .|| . |.||  .  ||.|
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_egg_pd Subfamily egg 2026-2259 3.5e-27 89.9 In-house 39-269 (307) alignment 
Range on Protein: 2026-2259
Range on HMM: 39-269/307.0
WNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgrIRCHQYWPEDNKPVTV
 |. | | . ..  .  ||||         |.| | ...|    |||| .| ||  || ||||||.. . . .||||   |    ||. |||  ..   |
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

--FGDIVITKLMEDVQID--WTIRDLKIerHGDCmtvRQCNFT-AWpeHGVPENSAPLIHFVKLVRASRAHdTTPMIVHCSAGVGRTGVFIALDHLTQHI
   | . |. |  | . |  ...  ||.   |     ..  |   |   |  .||. .   ....|  |   ..|..|..  || ......|..    ..
tvpGslrienlkvdskadplfrvtklkl..vGgd...deerflehw..qgdvnnssdvysplrvlrklrnl.skpvvvqdilGvskaatlvaieiallsl

NDHD--FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
         .   |  || .|   |.   .|.|... .| .
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2029-2265 2.3e-26 87.3 In-house 45-281 (312) alignment 
Range on Protein: 2029-2265
Range on HMM: 45-281/312.0
AKNRFPNIKPYNNNRVKLIADASVpgsdYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGD
  ||.|||. ..  |  |  |       || | ..     |. |..|||||  |.  ||...    . ....|.   | |  .| .|  .    | .   
dlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

IVITKLMEDVQIDW------TIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIhfvKLVRASRaHDTTPMIVHCSAGVGRTGVFIALDHLTQHI
 | |.   ...|        | | ||.     |.   . . ....||.||.|.         .|. | . .|  |.| |||||||||| .. .. .   .
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtlaliesmiaal

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
      ..      || .|   |. ..||..  .|.|..| .|| 
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
0048076 (Phosphotyrosine protein) phosphatases II 2142-2259 5.2e-24 80.0 In-house 31-142 (145) alignment 
Range on Protein: 2142-2259
Range on HMM: 31-142/145.0
WTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTQhindHDfVDIYGLVAELRSERMC
.|. .|  |...   .. |  .. || ||||. .. |..|...... ....  |..|||||||||||...|.. . .    .. |...  ....|| |..
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpg

MVQNLAQYIFLHQCILDL
.|.|  |..||....| |
avpnpgqlrflyefelel
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2071-2254 4.1e-23 76.6 In-house 5-197 (198) alignment 
Range on Protein: 2071-2254
Range on HMM: 5-197/198.0
EFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAW
 .|||| ||  |. |||.||||| .  .||. .   .       |||  .  .. .| . .|     .. |.||  | .            . . .||.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEHGVPeNSAPLIHFVKLVRA-SR---AHDTTPMIVHCSAGVGRTGVFIALDHLT-QHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQ
 |.  | | | .. ||   |  |.       .|.||||| | | ||||.|||     | .     ||.. .   ||  |  ..  | .| |..|
kekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2071-2254 4.5e-23 76.5 In-house 6-198 (199) alignment 
Range on Protein: 2071-2254
Range on HMM: 6-198/199.0
EFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAW
 .|||| ||  |. |||.||||| .  .||. .   .       |||  .  .. .| . .|     .. |.||  | .            . . .||.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEHGVPeNSAPLIHFVKLVRA-SR---AHDTTPMIVHCSAGVGRTGVFIALDHLT-QHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQ
 |.  | | | .. ||   |  |.       .|.||||| | | ||||.|||     | .     ||.. .   ||  |  ..  | .| |..|
kekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2072-2265 4.7e-22 73.3 In-house 39-226 (255) alignment 
Range on Protein: 2072-2265
Range on HMM: 39-226/255.0
FiatqgplpgTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVI--TKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEH
.         ||  |....  |.....|||.   |.|. .|..|.| .     .. |. .  || . || .      ... .     ||.  ... |.|.
l.........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiek

GVPENSAPLIHFVKLVRASRahdttPMIVHCSAGVGRTGVFIALDHLTQ----HINDHDFVDI--YGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
  ||..  . . .|.|| |.     ...||||.|.||.  |.  . . |     ..  . |..    |. ||||.| . ...  |  |    .|||.  |
naPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpk

GS
| 
ge
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2028-2120 6.4e-22 72.7 In-house 48-154 (350) alignment 
Range on Protein: 2028-2120
Range on HMM: 48-154/350.0
RAKNRFPNIKPYNNNRVKLI--------ADASVPGSDYINASYISGY----LCPNEF--IATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCH
 ||||. || ||. .||||          . |. ..|||||.|..          .|  ||||.||| || ||.... .   | ...||. .| .. .|.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPEDN
.||.| .
rYWqegs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2002-2263 8.6e-22 71.9 In-house 27-288 (302) alignment 
Range on Protein: 2002-2263
Range on HMM: 27-288/302.0
KFQEEFSELPKFLQDLSStDADLPWNRAKNRFPNIKPYNNNRVKLIADAsvpgSDYINASYISGYLCPNEFIATQGPLPGTV---GDFWRMVWETRAKTL
. ..|| .. ..  || .       | .||. .... ...|.||| | .     .|.||| ..   . .. | .| |  ...    .|||||.. . ...
evkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

VMLTQCFEKGRiRCHQYWPEDNKPVTVFGDIVITKL-MEDVQiDWTiRDLKIERH-GDCM---TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDT
|.| .  |  .   ....|.     . .|.. . .   | .. . .   . ||    .|     .    .| |... ||.. | ||. .. | |. .. .
vilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekae.eek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
 ....    |.|| |.|..|    ....... . |  .|. .||.| ..|..| ||..|. ..| .. .|
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
0048179 (Phosphotyrosine protein) phosphatases II 2144-2254 1.2e-21 72.4 In-house 33-139 (144) alignment 
Range on Protein: 2144-2254
Range on HMM: 33-139/144.0
IRDLKIERHGDCMT--VRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTqhindH-DfVDIYGLVAELRSERM
. .|  |.. ....  . |  .. || ||||. .. |..|...... ....  |..|||||||||||...|.. .      . . ....  .|..|| |.
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrp

CMVQNLAQYIFLHQ
..|.|  |..||..
gavpnpgqlrfLle
subfamily_hpo-7_pd Subfamily hpo-7 2080-2265 5e-20 66.5 In-house 44-232 (263) alignment 
Range on Protein: 2080-2265
Range on HMM: 44-232/263.0
PGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITklMEDVQIDWTIRDLKIER----HGDCMTVRQCNFTAWPEHGVPENS
  |.  |....  |.....|||.   |.|. .| .|.| .     .. .. ..    .|| |  .. |..           ||..  .. |.|.  ||..
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc..ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

APLIHFVKLVRASRahdttPMIVHCSAGVGRTGVFIALDHLTQ----HINDHDFVDI--YGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
   .. .|..| |.     ...||||.|.||.  |   . . |     ..  . |..    |. ||||.| . ...  |  |    .||.. |  .
reilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2155-2260 5e-20 66.2 In-house 88-194 (440) alignment 
Range on Protein: 2155-2260
Range on HMM: 88-194/440.0
CMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLH
. |..| .. .||..|||. ..|...... |  |. .    |..||||||.||||| ||.| . .. .  | .||. ..  .|..|  |||   || |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QCILDLL
...|. |
eavlegl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2040-2259 2.7e-18 61.1 In-house 31-258 (290) alignment 
Range on Protein: 2040-2259
Range on HMM: 31-258/290.0
NNNRVKLIADASVPGSDYINASYISgylCPN--EFIATQGPLPG-------TVGDFWRMVWETRAKTLVMLTQCFEKGRI----RCHQYWPEDNKPVTVF
...|| |    .   .||| |....   |||  ..|.|| |.         |. .|| |. . ..| .||| .  || .      | .| ||       |
eatrvvLkgygkrfnddyiHAnrvt...cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GDIVITKLMEDVQIDWTIRDLKIERH-GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASrahdTTPMIVHCSAGVGRTGVFIALDHLTQHIN-DHD
... .       . |  .| | ..   .  .||    .  | .  |.|..  |.. .. |.||    .||.||||  |. |  .. |..   | |   ..
kgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsg

FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
 | .  .. .||..|  ....  .. |    |. |
svkledvlkalrkqralaitsalelafvdagivll
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2081-2263 3.9e-18 60.0 In-house 102-291 (302) alignment 
Range on Protein: 2081-2263
Range on HMM: 102-291/302.0
GTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLM--EDVQ-----IDWTIRDLKIERH----GDCMTVRQCNFTAWPEH
 |.  .| .. . .    | |..  |..  .| .|. .. . .  ||   .. .   .|..      . ..  ..|. .       .||    |.|||.|
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPENSAPLIHFVKLVRASRahdtTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
| |... . .. .|   . .    . ..||||||||||| ..|. .  |    ..  |.  .|  .|. |   ||.  | |.|  |.   | .|
Gapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2021-2262 2.7e-17 57.3 In-house 41-281 (303) alignment 
Range on Protein: 2021-2262
Range on HMM: 41-281/303.0
DADLPWNRAKNRFPNIKPYNNNRVKLiADasvpgSDYINASYISgYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdN
  ..  |  |||| ..   .  .||| .|     | || |||.    . .  | || ||. |  |||.|. | . | ...|    |  ..  .  .|. |
knqfvknmdknrfvdvicldhskvkl.sd.....ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.n

KPVTVFGDIVIT-KLMEDVQI--DWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAP-LIHFVKLVRA--SRAHDTTPMIVHCSAGVGRTGVFIALD
.    | . .|    .  |..   |... | .        .    . |||   .| ...| ... .  ...   .  |.|| .    .|.||.| |  ..
qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfe

--HLTQHiNDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
  ||. | ..   .|.   .  .|  |.  ||||.|. ...  . . . .
tahlslh.seqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2189-2259 3.9e-16 53.7 In-house 258-343 (350) alignment 
Range on Protein: 2189-2259
Range on HMM: 258-343/350.0
RAHDTTPMIVHCSAGVGRTGVFIALDHLTQ----------HINDHDFV-----DIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
    ..|..|||||||||||....||.| .          . .  |        |  .| |||. |. ||||| |.||.....| .
dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
fn3 Fibronectin type III domain 667-742 1.9e-14 46.8 Pfam-A 1-81 (85) alignment 
Range on Protein: 667-742
Range on HMM: 1-81/85.0
SSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTL----YMKNTSTT-DIILRNLRPHTLYNISVRSYTRFGH
|.|... |..||.....|.||||....| |  ||| |.. ..       ....||   .|..|.|.| |...|..... | 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngage
subfamily_eak_pd Subfamily eak 2033-2263 1.2e-13 45.2 In-house 57-308 (332) alignment 
Range on Protein: 2033-2263
Range on HMM: 57-308/332.0
FPNIKPYNNNRVKLIADASVPgSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVIT
  .| ||. . |.| .    .   ||||| .      ...| |  .    |  ||.|| | .. ..|.| .  |..  .  .|.|.. . .  || . ..
vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

KLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA-------------PLIHFVK--LVRA--SRAHDTTP---MIVHCSAGVGRTGVFIA
.     .     | |....  .   |   ..  | |  .|                 .|.  .|  |...   . . | |    |. .. |  |.|||. 
rkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvv

LDHLTQHINDH--DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
.| | . |...  .   .  |.   .| |.  |    |. |... .|| | ..
idllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr
fn3 Fibronectin type III domain 575-650 2e-13 43.5 Pfam-A 6-84 (85) alignment 
Range on Protein: 575-650
Range on HMM: 6-84/85.0
INYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR-AFQITTIDNS--FLITGLKKYTKYKMRVAASTHVGESSL
.. ....|.|. | |.||. ..|.||.|..   | ....   ..|.  ..  . .|||| .|.|..||.| . .||.  
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 61-143 3.1e-13 42.8 Pfam-A 5-85 (85) alignment 
Range on Protein: 61-143
Range on HMM: 5-85/85.0
FLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEV-CPWmqtvYTQVRSKPDSL-EVLLTNLNPGTTYEIKVAAENSAGIGVFS
 |  . |.|  . |||. |....| | .| |.|.|.  ..    ... .. | .  .| ||.|.|||.||..|.| | || | .|
nlsvsevtstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2196-2258 9.1e-13 42.4 In-house 1-63 (69) alignment 
Range on Protein: 2196-2258
Range on HMM: 1-63/69.0
MIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
|.||||.| |||| |||.      |    .|||.  |  .|  |  || |  .|||.|  . .
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_CG42327_pd Subfamily CG42327 2187-2256 9.8e-13 42.4 In-house 241-311 (319) alignment 
Range on Protein: 2187-2256
Range on HMM: 241-311/319.0
ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCI
... ..  |..|||| ||||||. || |   .....    |||  ||  .| .|   |..  || |... .
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2021-2151 1.2e-12 42.0 In-house 90-213 (244) alignment 
Range on Protein: 2021-2151
Range on HMM: 90-213/244.0
DADLPWNRAKNRFPNIKPYNNNRVKLIAdASVpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgrircHQYWPeDN
||  | |  |||     |.. ||| |   .|. |  |||||..       |.| || ||  |  |||.|. |   . ||.|    |.      .||| | 
dafnpnnswknregaglpfdfnrvplsk.gsm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp.ds

KPVTVF-GDIVITKLMEDVQIDWTIRDLKIER
.|.  .  || .|    |   .    .|.|| 
eplewyeeditvtltdrdefknikasnleies
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1980-2077 1.5e-12 41.5 In-house 2-95 (95) alignment 
Range on Protein: 1980-2077
Range on HMM: 2-95/95.0
IKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADAsvpGSDYINASYISGYLCPNEFIATQG
.|||    |  || |. .| . .|..||  ..      . |      |  |||| || ||.  || | .      |||||| .. ||   | .||.||
fkpihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 1343-1418 4e-12 39.3 Pfam-A 3-85 (85) alignment 
Range on Protein: 1343-1418
Range on HMM: 3-85/85.0
VQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVER-------NSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDES
..|... ...  |. ..|.|||. .| || | |...        .. .|... . .|. .| ..|.|.|.|.| . |||| ||
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2193-2258 4.5e-12 40.4 In-house 228-293 (297) alignment 
Range on Protein: 2193-2258
Range on HMM: 228-293/297.0
TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
 ....|||||||||.|| .  | . . .  .   |.  ..  ||..|  .|| | |. .|.. .| 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2191-2260 4.7e-12 39.9 In-house 263-344 (349) alignment 
Range on Protein: 2191-2260
Range on HMM: 263-344/349.0
HDTTPMIVHCSAGVGRTGVFIALDHLTQ--HINDHDFV----------DIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
 ......|||||| |||||.. || | .  .   ....           |.  | |||  |. |||||||.|......|  .
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
fn3 Fibronectin type III domain 761-842 7.7e-12 38.4 Pfam-A 1-85 (85) alignment 
Range on Protein: 761-842
Range on HMM: 1-85/85.0
SAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNE-ERTINTTSLT--QNIKVLKKYTQYIIEVSASTLKGEGVRS
|||||.. ....| ...||. ||....| |..|.. .. ..|.| ........ |   ... || .|.| ..| | . .||| .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2029-2120 1e-11 38.8 In-house 50-157 (349) alignment 
Range on Protein: 2029-2120
Range on HMM: 50-157/349.0
AKNRFPNIKPYNNNRVKLIAD--------ASV------PGSDYINASYISGY--LCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRC
||||. .| ||.  ||||           ||          ||||| |..       . .|||| ||| || ||....   . | .. |.. .|..  .|
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPEDN
..|| | .
diywqels
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2197-2259 1.5e-11 38.5 In-house 1-63 (69) alignment 
Range on Protein: 2197-2259
Range on HMM: 1-63/69.0
IVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
.||||.| |||| |||.      |    .|||.  |  .|  |  || |  .|.|.|. . . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
fn3 Fibronectin type III domain 856-933 1.7e-11 37.3 Pfam-A 1-83 (85) alignment 
Range on Protein: 856-933
Range on HMM: 1-83/85.0
SPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNR--SS-LKTINVTETS--LELSDLDYNVEYSAYVTASTRFGDGK
|.|...||.. .  .. |||.|| ...| | .|.| ...   ..  |...|..|.  ..|..|  . ||.  |.| .. | |.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2064-2131 2.1e-11 37.8 In-house 230-293 (440) alignment 
Range on Protein: 2064-2131
Range on HMM: 230-293/440.0
SGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgriRCHQYWPEDNKPVTvFGDIVI
 ||   | ||||| ||  || ||||.| . |  |..|| |  .|    |  ||| . . || || . .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvt.fgpftv
fn3 Fibronectin type III domain 1245-1325 2.6e-11 36.7 Pfam-A 2-83 (85) alignment 
Range on Protein: 1245-1325
Range on HMM: 2-83/85.0
PPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDT-IYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGN
.|.||.... ||. . |.|||.. .|| .. |. .  | ..      ..... .|...| ||.| ..|..|| | ...|.| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1982-2066 1.6e-10 35.0 In-house 5-86 (440) alignment 
Range on Protein: 1982-2066
Range on HMM: 5-86/440.0
PISKKSFLQHVEElcTNNNLKFQEEFSELPKFLQDLsSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGY
||    | ..|..        |..|.| ||  |..  |  | || |. |||. ||  |...|| |    .|| |||||||||.| 
piivadfadyvqn..nrrsrafedewsllpsglsqp.sdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
fn3 Fibronectin type III domain 1158-1231 2e-10 33.8 Pfam-A 7-85 (85) alignment 
Range on Protein: 1158-1231
Range on HMM: 7-85/85.0
TFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNEN---YSFITSDNY--IILEELSPFTLYSFFAAARTRKGLGPSS
.... .|||. |||.|| ...| | .|.....  ...    .| .. .    .|..| | | |.|  .|....| ||.|
svsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1431-1526 3.2e-10 33.2 Pfam-A 1-85 (85) alignment 
Range on Protein: 1431-1526
Range on HMM: 1-85/85.0
SVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTqlraQ-----KckeweseecveyQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNA
| |.|. .|.|.|||.||.|  |..  | ...|...     .     .            .. ..  ... |. |. |||  . |.|.|.| ..||.| .
saPenlsvsevtstsltlsWsppkdgggpitgYevey....rekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

S
|
S
fn3 Fibronectin type III domain 1643-1732 8e-10 31.9 Pfam-A 1-83 (85) alignment 
Range on Protein: 1643-1732
Range on HMM: 1-83/85.0
DPPNNMTFQKIpdEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTavqiHNLSIIQKTNTFvIAMLEGLKGGHTYNISVYAVNSAGAGP
..| |...  .    |...|.. ||....|.|. |.  .  ....     .  ..  . .|   ..|.||| | .|...|.||| || ||
saPenlsvsev..tstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 950-1040 1.2e-09 31.3 Pfam-A 1-85 (85) alignment 
Range on Protein: 950-1040
Range on HMM: 1-85/85.0
DPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFmqnftlHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKS
..|...   . .|.|. | |.||....| |..|.| ||...|.       .... . .. | | .. .|.  . |.|...| . .|.|  |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2027-2101 1.9e-09 31.5 In-house 37-116 (347) alignment 
Range on Protein: 2027-2101
Range on HMM: 37-116/347.0
NRAKNRFPNIKPYNNNRVKLIADASV-----PGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
. .|||  . |  .. || |  . |      .   |||||.|    . .|.| || ||| || |||.||  |.   .| .
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
fn3 Fibronectin type III domain 1541-1618 2.6e-09 30.3 Pfam-A 2-79 (85) alignment 
Range on Protein: 1541-1618
Range on HMM: 2-79/85.0
PPENVHVVATSPFSISISWSEPA-VITGPTCYLIDVKSVDNDEFNISFIKSNEENkTIEIKDLEIFTRYSVVITAFTGN
.|||..| .... |...|||.|.      | | ........ |   .|  .. .. . ....|.  |.|.. ..| .|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2042-2155 1.3e-08 29.2 In-house 8-106 (130) alignment 
Range on Protein: 2042-2155
Range on HMM: 8-106/130.0
NRVKliadasvpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgrircHQYWPeDNKPVTVFGDIVITKLMEDVQID
.|..        | .|||||..      .|.. || ||  |  |||.|. |     ||.|    |.      .||| | .|.  . . .|  | .  . .
srlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp.dsePlewyeediivtltdrdefk

wTIRDLKIERHGDC
  |.  ..| . | 
.nikasnleiesdl
fn3 Fibronectin type III domain 308-386 1.8e-07 24.4 Pfam-A 2-85 (85) alignment 
Range on Protein: 308-386
Range on HMM: 2-85/85.0
PPQNCVTGNITGKSFSILWDPPTIVTGKF-SYRVELYGP-SGR--ILDNSTKDL-KFAFTNLTPFTMYDVYIAAETSAGTGPKS
.|.|    ..|  |... |.||.   |.. .|.||.    .|.     . ...   . .|.|.| | | . ..| . ||.|| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2003-2065 2.1e-07 24.8 In-house 15-76 (244) alignment 
Range on Protein: 2003-2065
Range on HMM: 15-76/244.0
FQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiADASVPGSDYINASYISG
 .|||  |  . ...  |.| |  | .|||. || |... || | . .   |||||||.|| |
akeefvglsdhtreflqtnavlsanatknryinilpfdetrvil.ssskkegsdyinanyiqg
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2008-2120 4.4e-07 23.0 In-house 6-88 (169) alignment 
Range on Protein: 2008-2120
Range on HMM: 6-88/169.0
SELPKFLQDL--SSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINAsyisgylcpnefiatqgplpgtvgdfwRMVWETRAKTLVMLTQCF
 || .|.. .      |.|  | .|||       .. ||||       |||||||                           ||.||| |  .|.| .. 
nelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtd

EKgrircHQYWPEDN
.|      ..||| .
dk.....nnfwpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2009-2120 6.9e-07 22.2 In-house 6-87 (169) alignment 
Range on Protein: 2009-2120
Range on HMM: 6-87/169.0
ELPKFLQD--LSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINAsyisgylcpnefiatqgplpgtvgdfwRMVWETRAKTLVMLTQCFE
|| .|..        |.|  | .|||       .. ||||       |||||||                           ||.||| |  .|.| .. .
elkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd

KgrircHQYWPEDN
|      ..||| .
k.....nnfwpeke
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2083-2264 1.4e-06 21.2 In-house 131-313 (346) alignment 
Range on Protein: 2083-2264
Range on HMM: 131-313/346.0
VGDFWRMVWETRAKtLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIH
| ||| |... . . || |    .| .      . ..|      | ..| .   ||  |     ...  |   | . ..    . |     | .. |.|.
vedfwymiyqeqih.lvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiik

FVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKG
...   . .   .. . |    | ||.  ||   .  . .|.    .|. .. ... .|   |. .|||  ..  ..| .. | 
mihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkr
fn3 Fibronectin type III domain 1058-1132 3.4e-06 20.3 Pfam-A 4-80 (85) alignment 
Range on Protein: 1058-1132
Range on HMM: 4-80/85.0
GNLTYESISSTAINVSWVPPA-QPNGLVFYYVSLILQQTPR-HVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKG
.||. ....|| ...|| ||. .   .. | | .  ..... ...  .   ..|  . .|. .|.| ....  ...|
enlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
0038934 (Phosphotyrosine protein) phosphatases II 2165-2213 3.6e-06 22.3 In-house 86-135 (194) alignment 
Range on Protein: 2165-2213
Range on HMM: 86-135/194.0
AWPEHGVPENSAPLIHFVKLVRASRAHD-TTPMIVHCSAGVGRTGVFIAL
 .|..|.. . . | .|..||    . |      ||| ||.||||...| 
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_PTPDC1_pd Subfamily PTPDC1 2159-2213 7.4e-06 20.5 In-house 84-134 (182) alignment 
Range on Protein: 2159-2213
Range on HMM: 84-134/182.0
RQCNFtAWPEHGVPENSApLIHFVKLVRASRAHDttPMIVHCSAGVGRTGVFIAL
  .|| .|...||.     ..  ||.|  .  ..   . ||| || ||||| || 
yvynf.gwkDygvasler.iLdivkvvafalqeg..kvavhChaGlGrtGvliac
fn3 Fibronectin type III domain 399-436 8.1e-06 19.1 Pfam-A 2-39 (85) alignment 
Range on Protein: 399-436
Range on HMM: 2-39/85.0
AVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLV
|. .|.. || ||.....|..|....| |  |.|..  
aPenlsvsevtstsltlsWsppkdgggpitgYeveyre