Gene PTPDC1-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP014_AA protein Get Run
MbreP014_AA_70-235 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPDC1_pd Subfamily PTPDC1 59-241 1e-87 287.3 In-house 3-182 (182) alignment 
Range on Protein: 59-241
Range on HMM: 3-182/182.0
AHAHNplNAFRGVNSTWVTENLLAMSRPLQGAIDAYHLPKKFAEAGITMVLNLQEPFEHSHCGAGVNRHGFSYSFESFQQQGVTVCNCAWVDFGSPPMER
.....  .|..|..||||||..||..|| | |||.|.| .||.|.||..|.||||..||..||||....||||..|....||..|.|..| |.|....||
wseee..qaikGlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasler

ALDIVKIMASVIQEGgKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYLHPRRAVY
.|||||..|...||| |.|||||||.||||..||.||......||.|||.||||.|||.||||.||....||...|.|.|.||
iLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfliplrkvy
PTEN_1 49-236 9.8e-42 138.0 In-house 2-194 (196) alignment 
Range on Protein: 49-236
Range on HMM: 2-194/196.0
GSKCKHCDYHAHAHNPLNAFRGVNSTWVTENLLAMSRPLQGaIDAYHLPKKFAEAGITMVLNLQEPFEHSHCGAGVNRHG--FSYSFESFQQQGVTVCNC
....|... . .|.. . . ...........  |.||||.      .| .....    .. ||.|.  ....     ..   .||. |.|...||.. ..
srlskrsskknlalptelldltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhf

AWVDFGSPPMERALDIVKIMASVIQE---GGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQR-PKTIQTRNQVKFLEEFDMYLHP
 . |.| |.... .||.| ... ...   |....|||.||.||.|...||||.... .|| .|..|||..| |  .... | ..||.|.. |. 
pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0046846 (Phosphotyrosine protein) phosphatases II 70-234 4e-40 132.8 In-house 9-172 (176) alignment 
Range on Protein: 70-234
Range on HMM: 9-172/176.0
GVNSTWVTENLLAMSRPLQGAID----AYHLPKKFAEAGITMVLNLQEPFEHSHCGagvnrhgFSYSFESFQQQGVTVCNCAWVDFGSPPMERALDIVKI
. .......||...|||. .  .     ..  . . |.|||.|.||.|..|.....       . . .. ... |...... |.|.| |..|  |.....
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk.......cpnywpeleklgiqylhlpwpDhgvpdlelllellef

MASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFH-NDYTAAKAIRLVRSQRP-KTIQTRNQVKFLEEFDMYL
. ....|||...|||.||.||||...||||. . ..... .|..|||.||| . .||..|..||.|| ..|
irealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0044763 (Phosphotyrosine protein) phosphatases II 64-238 2.1e-35 117.3 In-house 14-174 (178) alignment 
Range on Protein: 64-238
Range on HMM: 14-174/178.0
PLNAFRGVNSTWVTENLLAMSRPLqgaidaYHLPKKFAEAGITMVLNLQEPFEHSHCGagvnrhgfsYSFESFQQQGVTVCNCAWVDFGSPP-MERALDI
 |..... | ......|...| |        . .. . | |||...|| |..|. ...         .  . ... |...... ..|.| |. .|  |..
glersdyinaseilpglylgslpp......addlellkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdllehflef

VKIMASVI-QEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPkTIQTRNQVKFLEEFDMYLHPRR
|... ... ..||...|||.||.||.|...||||. ...... .||.|||..||  .....|...|.||...|.. .
vefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
0036282 (Phosphotyrosine protein) phosphatases II 71-234 2.2e-34 114.0 In-house 10-169 (174) alignment 
Range on Protein: 71-234
Range on HMM: 10-169/174.0
VNSTWVTENLLAMSRPLQgaidayhLPKKFAEAGITMVLNLQEPFEHSHCGAGVNRHGfsySFESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASVI
.. ...|..|.|.. ||.         . . | |||.|..| |..|  ...            |.. . |.... . |.|.| |...  |..||.. ...
ldlsyitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpe...lredlerlgiqylylpwpDhgvpdlsillefvkfveeal

QE--GGKIAVHCHAGRGRTGLIIAAYLIFHNDY-TAAKAIRLVRSQR---PKTIQTRNQVKFLEEFDMYL
.|  ||...|||.||.||||...||||. .. . .. .|..|||..|   |. .|| .| .|| .|...|
sedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0043147 (Phosphotyrosine protein) phosphatases II 71-236 2.4e-34 113.9 In-house 13-162 (172) alignment 
Range on Protein: 71-236
Range on HMM: 13-162/172.0
VNSTWVTENLLAMSRPlqGAIDAYHLPKKFAEAGITMVLNLQEPfehshcgagvnrhgfSYSFESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMAS--
.. .... ...|.  |  .  .  .  . . | |||...|| |                 |  | ....|.... . | |.| |..|  |...... .  
ldlyyipdrfiatqgp..lrntladfwrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidell

VIQEGGKIAVHCHAGRGRTGLIIAAYLIFhNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYLHP
....||...|||.|| ||||...||||.   .... .|..|||..||. .|. .| .|| .|. .|. 
alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
0041856 (Phosphotyrosine protein) phosphatases II 64-235 6.7e-34 112.4 In-house 17-171 (182) alignment 
Range on Protein: 64-235
Range on HMM: 17-171/182.0
PlnafrgvNSTWVTENLLAMSRPLQGAIDA--------YHLPKKFAEAGITMVLNLQepfehshcgagvnrhGFSYSFESFQQQGVTVCNCAWVDFGSPP
.       .......||...|.| .  | .        ..  . . | |||...||                .. |  | ....|.....  | |.| |.
r.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...............eelywpellerlgiqylylpwpDhgvpd

MERALDIVKIMASviqEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYLH
.. .||..... .   |||...|||.||.|||| ..||||. ...... .|..||||.||. ..| ||  ||  . ..|.
ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
0038934 (Phosphotyrosine protein) phosphatases II 73-230 3.8e-33 110.2 In-house 13-172 (194) alignment 
Range on Protein: 73-230
Range on HMM: 13-172/194.0
STWVTENLLAMSRPLQGAIDAYhlPKKFAEAGITMVLNLQEPFEHsHCGAGVNR--HGFSYSFESFQQQGVTVCNCAWVDFG-SPPMERALDIVKIMASV
....|....|...||.| .| |   . .   ........ . . . ..|. ..   ... |. | |.. |... .. ..|.| .|..|  |......  .
gdiitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnv.klglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdef

IQE--GGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEF
..|  ||..||||.||.||||...||||| .....| .||.|.|. ||. |....... | ..
lnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
0037934 (Phosphotyrosine protein) phosphatases II 66-233 1.2e-32 108.8 In-house 32-240 (243) alignment 
Range on Protein: 66-233
Range on HMM: 32-240/243.0
NAFRGVNSTWVTENLLAMSRPLQGAIDA--YHLPKKFAEAGITMVLNLQEPFEHSHCGAGVN------------------------RHGFS---YSFESF
. .   | ..||..| |.. ||.. ..   ..  . . | |||....| |..|.....                             . ..   .. . .
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

QQQGVTVCNCAWVDFGSPP-MERALDIVKIMASVIQE---------GGKIAVHCHAGRGRTGLIIAAYLIFHN-DYTAAKAIRLVRSQRPK-TIQTRNQV
..... ..  .| |.| |. .|  ||..... ..|.|         ||...|||.||.||||..|||||. .. .... .|..|.|.|||   .||..| 
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

KFLEEFDMY
.|| |. ..
rflyealle
0042113 (Phosphotyrosine protein) phosphatases II 69-234 1.2e-31 105.4 In-house 43-242 (245) alignment 
Range on Protein: 69-234
Range on HMM: 43-242/245.0
RGVNSTWVTENLLAMSRPLQGaiDAYHLPKKFAEAGITMVLNLQEPFEHSHC--------------------------GAGVNRHGFSYS--FESFQQQG
  |.  ..|....|.. ||..  .  .  . . | |||....| |..|....                           ... .  .. .   .......
syvdgyritpkfiatqgPlpe..tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrev

VTVCNCAWVDFGSPP-MERALDIVKIMASVIQ--EGGKIAVHCHAGRGRTGLIIAAYLI-----FHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDM
....   | |.| |. .|  ||..... ....  ..|...|||.||.||||..|||||.      . .... .|.. .|||||. .|| .| .|| |. .
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

YL
.|
el
0048076 (Phosphotyrosine protein) phosphatases II 96-235 1.2e-31 104.7 In-house 21-143 (145) alignment 
Range on Protein: 96-235
Range on HMM: 21-143/145.0
LPKKFAEAGITMVLNLqepfehshcgagvnrhgfSYSFESFQQQGVTVCNCAWVDFGSPPM-ERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAY
  . ... |||.||||                  .. .| . ..|...... | |.| |.. |  |...... ....|||...|||.||.||||...|||
dlellkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYLH
|........ .|..|||||||. ... .|..||.||...|.
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelell
0048179 (Phosphotyrosine protein) phosphatases II 97-232 3.7e-31 103.2 In-house 22-142 (144) alignment 
Range on Protein: 97-232
Range on HMM: 22-142/144.0
PKKFAEAGITMVLNLQEPFEHSHCGAGvnrhgfsysfesfqqqGVTVCNCAWVDFGSPPM-ERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYL
 . ... |||.|.||.|..|. ...                  |...... | |.| |.. |  |...... ....|||...|||.||.||||...||||
lellkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

IFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDM
........ .|..||||.||  .....|..||.|.. 
mkklglsleealalvrsrrpgavpnpgqlrfLleyek
0045098 (Phosphotyrosine protein) phosphatases II 93-236 1.4e-30 102.1 In-house 77-273 (278) alignment 
Range on Protein: 93-236
Range on HMM: 77-273/278.0
AYHLPKKFAEAGITMVLNLQEPFEHS---------------------------HCGAGVNRHGFSYSF----ESFQQQGVTVCNC-AWVDFGSPPME---
. .  . . | ||| ...| | .| .                           ...  . |.   . .    |.... |||. ..  | |.|.|...   
vadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilk

RALDIVKIMASVIQ--------------EGGKIAVHCHAGRGRTGLIIAAYLIFHN---DYTAAKAIRLVRSQRPK-TIQTRNQVKFLEEFDMYLHP
  |.... . ....              .||...|||.|| |||| ..||||. ..    ... .|.. .|||||   .|. .| .||.|| ..|. 
sflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0039614 (Phosphotyrosine protein) phosphatases II 50-234 3.8e-30 100.8 In-house 58-288 (297) alignment 
Range on Protein: 50-234
Range on HMM: 58-288/297.0
SKCKHCDYHAHAHNPLNA--FRG--VNSTWV-----------TENLLAMSRPLQGAIDAYhlPKKFAEAGITMVLNLQEPFEHSH---------------
.|. . |. .  |.      ..|   .|...           | . .|.. ||.. .. .   . . | |.|....| ...|...               
dknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF..wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygd

---------CGAGVNRHGFSYSFESFQQQGVTVCNCAWVDFGSPP-MERALDIVKIMASVIQ---EGGKIAVHCHAGRGRTGLIIAAYLI-----FHNDY
           .|...  .. . ..   .   ..   | |.| || .|  |...... ....   .||...|||.|| |||| .|||||.      . ..
ftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

TAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYL
.. .|.. .|.|||. .|| .| .|| .. ..|
dvleavkelreqRpgavqtpsqyrflydallel
0045450 (Phosphotyrosine protein) phosphatases II 41-234 1.2e-29 99.5 In-house 48-303 (307) alignment 
Range on Protein: 41-234
Range on HMM: 48-303/307.0
RVCKLFCKGSKCKHCDYHAHAHN----------------------PLNAFRGVNSTWVTENLLAMSRPLQGAIDAYhlPKKFAEAGITMVLNLQEPFEHS
.. .| . ..|. . |. .  |.                       .. .. ... ... . .|.  ||.. .. .   . . | |.|....| |..|. 
siallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF..wrmlweqgvtvivmltelvelg

H---------------------------CGAGVNRHGFSYSF---ESFQQQGVTVCNCAWVDFGSPP-MERALDIVKIMASVIQ---EGGKIAVHCHAGR
.                             .|. .. .  .    ...  .    .  .| |.| || .| .||..... ....   .||...|||.|| 
rekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGv

GRTGLIIAAYLIFHND--------YTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYL
|||| .|||||. ..         ... .|..|.|.|||. .|. .| .|| |. ..|
gRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0049260 (Phosphotyrosine protein) phosphatases II 98-231 2.7e-29 97.2 In-house 27-146 (152) alignment 
Range on Protein: 98-231
Range on HMM: 27-146/152.0
KKFAEAGITMVLNLQEPFEHSHCGAGVNRhgfsysfesfqqqgvTVCNCAWVDFGSPPMERALDIVKIMASV--IQEGGKIAVHCHAGRGRTGLIIAAYL
. . | ||| ...| |..|  ...                    ..... | |.| |...  |... ..     ...||...|||.|| ||||...||||
rmlkelgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

IFhNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFD
.  ..... .|..|||..||. ... .| .|| ||.
ml.lgvsleeavalvrekRpgavpnpgqlrflyefe
0040439 (Phosphotyrosine protein) phosphatases II 69-234 7e-29 96.6 In-house 34-245 (249) alignment 
Range on Protein: 69-234
Range on HMM: 34-245/249.0
RG-----------VNSTWVTENLLAMSRPLQGAIDAYhlPKKFAEAGITMVLNLQEPFEHSHCG--AGVNRHGFS-------------------------
.|           .. .... ...|.. ||.......   . . | |||....| ...|. ...     .  |.                          
pglflsdyinAsyidgyyikrrfiatqgPlpetvedf..wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---YSFESFQQQGVTVCNCAwvDFGSP-PMERALDIVKIMASVIQ---EGGKIAVHCHAGRGRTGLIIAAYLI-----FHNDYTAAKAIRLVRSQRPKTI
   |  ||.. ... . ..   |.| |  .| .||..... ....   .||...|||.|| ||||..|||||.      ......  |..|.|||||. .
tnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgav

QTRNQVKFLEEFDMYL
|. .| .|| |. ..|
qnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 71-233 1.9e-28 95.2 In-house 81-275 (278) alignment 
Range on Protein: 71-233
Range on HMM: 81-275/278.0
VNSTWVTENLLAMSRPLQGAIDAYhlPKKFAEAGITMVLNLQEPFEHSHC-------------------------GAGVNRHGFSYS--FESFQQQGVTV
|.  .|... .|.. ||.. .. .   . . | |.|....| |..|....                          ... .. .  .   ... .... .
vdgynvprkfiatqgPlpetvedF..wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthy

CNCAWVDFGSP-PMERALDIVKIMASVIQ-EGGKIAVHCHAGRGRTGLIIAAYLI-----FHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMY
.  .| |.| | ...  ||..|.. .... ..|...|||.|| ||||..||.||.      .  ... .|.. .|.|||. .|| .| .|| |. ..
hylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 71-242 5.1e-27 90.4 In-house 79-283 (317) alignment 
Range on Protein: 71-242
Range on HMM: 79-283/317.0
VNSTWVTENLLAMSRPLQGaiDAYHLPKKFAEAGITMVLNLQEPFEHS---------------------------HcGAGVNRHGFSYSF-ESFQQQGVT
|.  . . . .|.. ||..    ..  . . | |.|....| |..| .                           .  ||.. . .  .  .. ..  ||
vdgpnlkrkfIatqgPlpn..tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvt

VCNCAW-VDFGSPP-MERALDIVKIMASVIQE-GGKIAVHCHAGRGRTGLIIAAYLI-----FHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYL
.  . .  |.| || ..  ||..... ..... ||...|||.|| |||| .|||||.      ...... .|.. .|.|||. .|| .| .|| .. ...
hfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley

HPRRAVYH
. |. .. 
lkrkltle
0051082 (Phosphotyrosine protein) phosphatases II 71-227 9.4e-27 88.9 In-house 6-145 (151) alignment 
Range on Protein: 71-227
Range on HMM: 6-145/151.0
VNSTWVTENLLAMSRPLQgaidayHLPKKFAEAGITMVLNLQEPFEHShcgagvnrhgfsYSFESFQQQGVTVCNCAWVDFGSPPM----ERALDIVKIM
 | ..||..|.... ||.      .  . ..| ||....|| ...|.             |  | ....|..|... ..|.  |..    . .|......
infsyvtgglyrsggpla......dflellkelgiktivnlrseeerg............ycpeylpelgievlhipildwpdpglplsfdavleflell

ASviQEGGKIAVHCHAGRGRTGLIIAAYLIFhNDYTAAKAIRLVRSQRPKTIQTRNQVKFL
..  ...|...|||.||.||||...|.||.   ......|.. .|..||  .|. .|  |.
ld..kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0049772 (Phosphotyrosine protein) phosphatases II 129-238 1.5e-25 86.0 In-house 169-277 (314) alignment 
Range on Protein: 129-238
Range on HMM: 169-277/314.0
FSYSFESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASViQEGGKIAVHCHAGRGRTG-LIIAAYLIFHNDYTAAKAIRLVRSQRPkTIQTRNQVKFL
  |. | |...|...... . |.. |. |  ....... .. ..||...|||.||.|||| ...||||. ........|.. ||..||     ......|
elydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieql

EEFDMYLHPRR
|.. ..|. ..
eqyefileall
0051429 (Phosphotyrosine protein) phosphatases II 75-234 6.7e-25 83.7 In-house 18-224 (272) alignment 
Range on Protein: 75-234
Range on HMM: 18-224/272.0
WVTEN-LLAMSRPLQGaiDAYHLPKKfAEAGITMVLNLQEPFEHSHCGAGVNRHGFSYSFESFQQQGVTVC-----------------------------
.| .. |.....||.   .| ....  .| ||.....| ...|. ...     .|. | . ..   ...                               
vvkpgrlyrsggplpl..taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlll

------------NCAWVDFGSPPmERALDIVKIMASviqeGGKIAVHCHAGRGRTGLIIAAYLIFhNDYT--------------AAKAIRLVRSQRPKTI
             ..|.|.| |. |  |........    ||.. |||.||..|||...|..|.   . .              ...|.. .|.|||. .
sagearevmhlhytdwpdhgvpq.eallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgav

QTRNQVKFLEEFDMYL
||  |..|| |. . |
qteeqylflyeallel
0036941 (Phosphotyrosine protein) phosphatases II 91-237 2.1e-23 78.5 In-house 71-279 (297) alignment 
Range on Protein: 91-237
Range on HMM: 71-279/297.0
IDAYHLPKKFA------------------EAGITMVLNLQEPFEHSHC------------------------------GAGVNRHGFSYSF-ESFQQQGV
.| |.|..||                   | ..|....| |..|                                   ... .. .  .. .. ..  |
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

TVCNC-AWVDFGSPP-MERALDIVKIMASVIQ---EGGKIAVHCHAGRGRTGLIIAAYLI--------FHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLE
|.. .  | |.| |. ..  ||... . .|..   .||.. |||.|| ||.| .|||.|.         .. ..  .|.. .|.|||  .|| .| .|| 
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

EFDMYLHPR
|. ..|  .
eallellkk
0046845 (Phosphotyrosine protein) phosphatases II 73-230 5e-22 74.0 In-house 72-269 (284) alignment 
Range on Protein: 73-230
Range on HMM: 72-269/284.0
STWVTENLLAMSRPLQGAIDAYHlpKKFAEAGITMVLNLQEPFEHSH--C-------------------------GAGVNRHGFSYSF---ESFQQQGVT
 |... . .|.. ||.. .. .   .   | .....  | |..| ..  |                           .. .. .. ..   ...  .   
ltyikkkfIatqgPlpntvedFw..rmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvth

VCNCAWVDFGSPP-MERALDIVKIMASVIQE---GGKIAVHCHAGRGRTGLIIAAYLIFHN--------DYTAAKAIRLVRSQRPKTIQTRNQVKFLEEF
 .  .| |.| || .|  |...... .....   ||.|.|||.|| |||| .||..|...          ... .|.. .|.|||  .||  | .|. |.
fhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea
0047943 (Phosphotyrosine protein) phosphatases II 140-228 7.4e-22 73.5 In-house 168-265 (273) alignment 
Range on Protein: 140-228
Range on HMM: 168-265/273.0
GVTVCNCAWVDFGSP-PMERALDIVKIMASVIQ---EGGKIAVHCHAGRGRTGLIIAAYLI-----FHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLE
   ..   | |.| |  .|  |...... ....   ..|...|||.|| |||| .||..|.      ..  .. .|..|.|||||  .|| .| .|| 
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0050432 (Phosphotyrosine protein) phosphatases II 144-227 6.4e-21 70.4 In-house 189-291 (308) alignment 
Range on Protein: 144-227
Range on HMM: 189-291/308.0
CN--------------CAWVDFGSPP-MERALDIVKIMASVIqEGGKIAVHCHAGRGRTGLIIAAYLI-----FHNDYTAAKAIRLVRSQRPKTIQTRNQ
.|               .| |.| || .|  ||..... ... .||.|.|||.|| |||| .||..|.      ..  .. .|.. .|.|||  .|| .|
tnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq

VKFL
 .||
ylfl
0051299 (Phosphotyrosine protein) phosphatases II 133-227 4.9e-20 67.6 In-house 177-278 (288) alignment 
Range on Protein: 133-227
Range on HMM: 177-278/288.0
FESFQQQGVTVCNCAWVDFGSPP-MERALDIVKIMASVIQE-GGKIAVHCHAGRGRTGLIIAAYLI-----FHNDYTAAKAIRLVRSQRPKTIQTRNQVK
.... ..    .  .| |.| |. .|  ||..... ....  || ..|||.|| |||| .||..|.     ...  .. .|.. .|.|||  .|| .| .
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyr

FL
|.
fv
subfamily_PTPMT1_pd Subfamily PTPMT1 129-234 5.4e-19 63.3 In-house 62-168 (171) alignment 
Range on Protein: 129-234
Range on HMM: 62-168/171.0
FSYSFESFQQQGVTVCNCAWVDFG-SPPMERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFL
.. | |.....||.  . | |||  .| .|. .. |... .|...| .. |||.|||||.. ..|.||. ..  .  .|.. ....|...   ..|.| |
lansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkal

EEFDMYL
.|.   |
qeyeekl
PTPc_motif_SM00404 97-229 8.3e-18 59.6 In-house 20-136 (140) alignment 
Range on Protein: 97-229
Range on HMM: 20-136/140.0
PKKFAEAGITMVLNLQEPFEHShcgagvnrhgfsysfesFQQQGVTVCNCAWVDFGSPPMERALDI-VKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYL
|.. .. |||.|.|..|  . .                  ...|......   | .. .. . ||  .... .....|||. ||| ||  |.. .|.|||
pallkklgithvinvteevslt.................kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl

IFHNDYTAAKAIRLVRSQRpKTIQT-RNQVKFLEE
.  . ...|.|...|...| ..|.   | |. | |
mryrqlslaeayefvkerR.piispnlnfvrqLie
subfamily_CDC14_pd Subfamily CDC14 98-229 1.5e-17 58.5 In-house 206-318 (328) alignment 
Range on Protein: 98-229
Range on HMM: 206-318/328.0
KKFAEAGITMVLNLQEPfehshcgagvnrhgfSYSFESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASViqeGGKIAVHCHAGRGRTGLIIAAYLIF
. |.. ..| |. | .                 |  ..|...|.   .  ..| . |. .     ..|. ..    |.|||||.|| |||| .||.||. 
eyfrknnvttvvrLnkk...............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmk

HNDYTAAKAIRLVRSQRPKTIQTRnQVKFLEE
|  .||| ||  .|  || .. .  | |||||
hyrftaaeaiawlricrPGsvigp.qqkflee
DSPc Dual specificity phosphatase, catalytic domain 98-230 1.8e-17 58.4 Pfam-A 12-130 (133) alignment 
Range on Protein: 98-230
Range on HMM: 12-130/133.0
KKFAEAGITMVLNLQEPFEHShcgagvnrhgF----------SYSFESfqqqgvtvcncawvdFGSPPMERAL-DIVKIMASVIQEGGKIAVHCHAGRGR
.. .. |||.|.|...  ...          .          ..  |                . .  ... | ..|.......|.|.|..||| ||  |
alleklgitlvinvtkevpnn..........naikkseieylripved...............etetkiskeleeavefiekaeqkgkkvlVHCqaGisR

TGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEF
.. .|.|||.  . ... .|...|...|.|  .. .... | |.
SatliiaYlmktknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 98-230 1.8e-17 58.4 In-house 12-130 (133) alignment 
Range on Protein: 98-230
Range on HMM: 12-130/133.0
KKFAEAGITMVLNLQEPFEHShcgagvnrhgF----------SYSFESfqqqgvtvcncawvdFGSPPMERAL-DIVKIMASVIQEGGKIAVHCHAGRGR
.. .. |||.|.|...  ...          .          ..  |                . .  ... | ..|.......|.|.|..||| ||  |
alleklgitlvinvtkevpnn..........naikkseieylripved...............etetkiskeleeavefiekaeqkgkkvlVHCqaGisR

TGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEF
.. .|.|||.  . ... .|...|...|.|  .. .... | |.
SatliiaYlmktknlslneAyefvkerrskispnagflrqLley
subfamily_DSP23_pd Subfamily DSP23 140-234 3.9e-17 57.3 In-house 51-145 (148) alignment 
Range on Protein: 140-234
Range on HMM: 51-145/148.0
GVTVCNCAWVDFGSPPMERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYL
..|. .    |.  | .|.  ..|...    . .  ..|||  |||||| ..| ||. ... .||.||  || .|| ...| .| | . ... ..
nltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi
0048567 (Phosphotyrosine protein) phosphatases II 147-234 1.5e-16 55.1 In-house 44-138 (157) alignment 
Range on Protein: 147-234
Range on HMM: 44-138/157.0
AWVDFGSPPMERALDIVKIMASVIQ----EGGKIAVHCHAGR---GRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYL
 . ||| ... .  . .... ....    .|..|||||.||.   |||...|..||| |...|...||...|  ||. .  | .  .|  ....|
fffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltl
subfamily_PRL_pd Subfamily PRL 129-231 3.6e-14 47.1 In-house 44-146 (151) alignment 
Range on Protein: 129-231
Range on HMM: 44-146/151.0
FSYSFESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASVIQEGG--KIAVHCHAGRGRTGLIIAAYLIfHNDYTAAKAIRLVRSQRPKTIQTrNQVKF
 .|. |.....|..| . |. | ..|| |   . .... .  .| .   .|||| || ||. ...|  ||  .  .  .|....|..|  .| . .|.||
ptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali.eaGmkyedavefirekrrgains.kqlkf

LEEFD
||.. 
lekyk
PTPc_DSPc_SM00012 147-227 1.4e-13 46.3 In-house 9-99 (105) alignment 
Range on Protein: 147-227
Range on HMM: 9-99/105.0
AWVDFGSPP-MERALDIVKIMASVIQE---GGKIAVHCHAGRGRTGLIIAAYLIFHNDYTA------AKAIRLVRSQRPKTIQTRNQVKFL
.| |.| |  ..  |.... . .. ..   .. . |||.|| |||| ..|.... .. ..        . .. .|.|||...|| .|. ||
gwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_PTEN_pd Subfamily PTEN 74-232 1.1e-12 43.4 In-house 23-177 (184) alignment 
Range on Protein: 74-232
Range on HMM: 23-177/184.0
TWVTENLLAMSRPLQGAIDAYHLPKKfaeaGITMVLNLQEpfeHSHCGAGVNRHGFSYSFESFQQQgvtVCNCAWVDFGSPPMERALDIVKIMASVIQEG
...|||..||. | ..   .|   ..     .. .|. .    . |      | . .|. ..|...   |  .   |  .||.|   .||. . . ..| 
syiteniiamgyPaeklealyRnsle....dvvkflekkh...kdhykiynlrserkydskkfdgr...vavypfdDhnppplelleeivediekwleed

GK--IAVHCHAGRGRTGLIIAAYLIFHNDYTAA-KAIRL---VRSQRPKTIQTRNQVKFLEEFDM
 |  ..|||.||.||||..|.|||. .. .. | .|..|   .|..  |...   | ...| .. 
kknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyek
subfamily_DSP3_pd Subfamily DSP3 98-215 1.7e-12 41.3 In-house 30-139 (162) alignment 
Range on Protein: 98-215
Range on HMM: 30-139/162.0
KKFAEAGITMVLNLQEPfEHSHcgagVNRHGFSYSFESFQQQGVTVCNCAWVDFgSPPMERALDIvkIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIF
.|....||| |||  |  ..|.    |. .   |.  ...  |. | .   .|. |   |.| .   | ... |. ||. |||..|  |   .. |||. 
skLkklGithvlnaaeg.rfsk....vdtgaefykdleikylGlevdDvpefdl.skyFetaakf..idealsqkegkvlvhcvvGvsRsatlvlayLmi

HNDYTAAKAIRLVRSQRP
... |. .||| ||..| 
rrkmtlveairtvrkkRe
subfamily_CDKN3_pd Subfamily CDKN3 132-231 9.2e-12 38.9 In-house 91-192 (202) alignment 
Range on Protein: 132-231
Range on HMM: 91-192/202.0
SFESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAA-KAIRLVRSQR-PKTIQTRNQVKFLEE
 .. .|| |..|      | . | .   |.|.. .   .... |  |||. | ||. |.||  |.. .|.    .||  .|  .  ..|||  |  .|.|
lldlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylse

FD
| 
fr
Y_phosphatase Protein-tyrosine phosphatase 147-227 2.5e-11 38.8 Pfam-A 142-229 (235) alignment 
Range on Protein: 147-227
Range on HMM: 142-229/235.0
AWVDFGSPpmERALDIVKIMASVIQEG----GKIAVHCHAGRGRTGLIIAAYLIFHNDYT-----AAKAIRLVRSQRPKTIQTRNQVKFL
.| | | |  | . ...... .| ..     |.. ||| || |||| ..|. .....  .       .... .|.|||. .|. .| .||
nWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 147-227 2.5e-11 38.8 In-house 142-229 (235) alignment 
Range on Protein: 147-227
Range on HMM: 142-229/235.0
AWVDFGSPpmERALDIVKIMASVIQEG----GKIAVHCHAGRGRTGLIIAAYLIFHNDYT-----AAKAIRLVRSQRPKTIQTRNQVKFL
.| | | |  | . ...... .| ..     |.. ||| || |||| ..|. .....  .       .... .|.|||. .|. .| .||
nWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
subfamily_RNGTT_pd Subfamily RNGTT 148-224 6e-11 36.4 In-house 85-164 (189) alignment 
Range on Protein: 148-224
Range on HMM: 85-164/189.0
WVDFGS-PPMERALDIVKIMASVIQE--GGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQV
    |  |  |.   . |.. . ...     |.|||. |  ||| .|..||. ..|. . .|..| .. ||. |   . .
cagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedyl
subfamily_Tensin_pd Subfamily Tensin 70-204 1.9e-10 33.6 In-house 10-135 (189) alignment 
Range on Protein: 70-204
Range on HMM: 10-135/189.0
GVNSTWVTENLLAMSRPLQGAIDAYHlpKKFAEagITMVlnLQEPFEHSHcgAGVNRHGFSYSFESFQQQgvtVCNCAWVDFGSPPMERALDIVKIMASV
... |..|| ..|.| | .|  ..|   ... .  .. .  |..  ...      |    .|  ......   | .  | |  .|..|.   |.| . | 
dldltyiteriialsfpaegleekyr..enlkd..vakl..lkskhndky..lvfnlsekrydisklnkk...vldfGWPdllaPsleklcsicksldsW

IQEGGK--IAVHCHAGRGRTGLIIAAYLIFHNDYTAA
...  .  ..|||. |.||.|....||. . .  ..|
lkadpqnvvvvhckGgkgrigvvvsaymkyskisasa
DSPc_SM00195 122-228 2.5e-10 35.5 In-house 140-255 (263) alignment 
Range on Protein: 122-228
Range on HMM: 140-255/263.0
AGVNRHGFSYSFES-FQQQGVTVCNC-AWVDFGSP-PMERALDIVKIMASVIQ-EGGKIAVHCHAGRGRTGLIIAAYLIFH-----NDYTAAKAIRLVRS
. .... .....|   ... ||. .. .| | | |  ..  |.... . .  . . | | |||.|| |||| .... .| .     ...   . .. .|.
deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRk

QRPKTIQTRNQVKFLE
|||. .||..| .|. 
qRpgmvqtleqYlfiy
PTPc_SM00194 122-228 2.5e-10 35.5 In-house 140-255 (263) alignment 
Range on Protein: 122-228
Range on HMM: 140-255/263.0
AGVNRHGFSYSFES-FQQQGVTVCNC-AWVDFGSP-PMERALDIVKIMASVIQ-EGGKIAVHCHAGRGRTGLIIAAYLIFH-----NDYTAAKAIRLVRS
. .... .....|   ... ||. .. .| | | |  ..  |.... . .  . . | | |||.|| |||| .... .| .     ...   . .. .|.
deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRk

QRPKTIQTRNQVKFLE
|||. .||..| .|. 
qRpgmvqtleqYlfiy
subfamily_PTPN13_pd Subfamily PTPN13 146-227 3.4e-10 34.6 In-house 174-261 (273) alignment 
Range on Protein: 146-227
Range on HMM: 174-261/273.0
CAWVDFGSPPME-RALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIF-----HNDYTAAKAIRLVRSQRPKTIQTRNQVKFL
 .| | | |      | .|. .... .. | |.||| || ||.| .|. . ..      ...   . .| .| ||   .||..|  | 
vkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv
subfamily_VSP_pd Subfamily VSP 72-206 1.4e-09 32.2 In-house 35-161 (212) alignment 
Range on Protein: 72-206
Range on HMM: 35-161/212.0
NSTWVTENLLAMSRPLQGAIDAYHLPKKfaEagITMVLNLQEPFEHSHCGAGVNRHgfsYSFESFQQQgvtVCNCAWVDFGSPPMERALDIVKIMASVIQ
. |.||| ..||| |  |    |  | .  |  ..  |. . . ..       .|.   |  . |...   | ..   |   | .|. | . |..   ..
dltyvteriiamsfpssGkqslyrnpis..e..varfldtkhrdhykvvnlcsera...ydekyfnnr...vkriliddhnvpkleellvftkevkewle

EGGK--IAVHCHAGRGRTGLIIAAYLIFHNDYTAAKA
.  |  .|.||  |.|||| |. |.|.  . .. || 
kdlknvlaihckGGkgrtGtivcalllaseifetake
subfamily_PTPRA_pd Subfamily PTPRA 147-227 1.7e-09 32.1 In-house 200-287 (330) alignment 
Range on Protein: 147-227
Range on HMM: 200-287/330.0
AWVDFGSPPMERA-LDIVK-IMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYT-----AAKAIRLVRSQRPKTIQTRNQVKFL
.| |.| |   .  |...| . .   |..| | ||| || ||||  |.   ...   .       .... .| |||. .|| .| .|.
swPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi
subfamily_PTPRB_pd Subfamily PTPRB 146-229 1.8e-09 32.0 In-house 187-279 (293) alignment 
Range on Protein: 146-229
Range on HMM: 187-279/293.0
CAWVDFGSPPME-RALDIVKIMASVI---QEGGKIAVHCHAGRGRTGLIIAAYLIF----HNDYTA-AKAIRLVRSQRPKTIQTRNQVKFLEE
 .|.|.| |      ||.|. . ..|   .. . | ||| || ||||  ||   ..    ..||   .  .  .|..|   .|| .|  |...
tsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihq
subfamily_DSP19_pd Subfamily DSP19 166-217 2.1e-09 31.9 In-house 82-133 (152) alignment 
Range on Protein: 166-217
Range on HMM: 82-133/152.0
MASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKT
. .. .. | . |||.||. |.  .. |||. ... .  .|..|||..||  
ieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci
subfamily_DSP12_pd Subfamily DSP12 162-226 2.6e-09 31.6 In-house 71-135 (155) alignment 
Range on Protein: 162-226
Range on HMM: 71-135/155.0
IVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKF
.|. . . ..|.|.. |||.||  |   |..|||. ...    ||..||....|..    . .. 
avdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQ
subfamily_DSP1_pd Subfamily DSP1 162-216 6e-09 30.2 In-house 84-138 (163) alignment 
Range on Protein: 162-216
Range on HMM: 84-138/163.0
IVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPK
... . .|....||. .||.||  |   .. |||. .. ..  .|  .|...|. 
viefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi
subfamily_DSP14_pd Subfamily DSP14 162-216 1.2e-08 29.1 In-house 72-126 (157) alignment 
Range on Protein: 162-216
Range on HMM: 72-126/157.0
IVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPK
... . .| ..|||. ||| ||. |   .  |||. ..  . ..| .||.|.|| 
vadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpi
subfamily_PTPN12_pd Subfamily PTPN12 146-227 1.3e-08 29.1 In-house 178-269 (290) alignment 
Range on Protein: 146-227
Range on HMM: 178-269/290.0
CAWVDFGSPPM-ERALDIVKIMASVIQ-EGGKIAVHCHAGRGRTGLIIAAYLIFHN--------DYTAAKAIRLVRSQRPKTIQTRNQVKFL
 || | | |   .. |.... . .. . |   ..||| || |||| |||  .. .         ..   . .. .| ||.  .||..| ...
taWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelv
subfamily_PTPRK_pd Subfamily PTPRK 147-229 1.7e-08 28.7 In-house 182-271 (314) alignment 
Range on Protein: 147-229
Range on HMM: 182-271/314.0
AWVDFGSPPMERAL-DIV-KIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFH-----NDYTAAKAIRLVRSQRPKTIQTRNQVKFLEE
.| |.. |  ...| ..| .. .|  .| |.| ||| || ||||  ||   .       .     .|.. .||...  ..| .| ||. .
gWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiyd
subfamily_PTPN6_pd Subfamily PTPN6 164-228 2.1e-08 28.5 In-house 217-290 (306) alignment 
Range on Protein: 164-228
Range on HMM: 217-290/306.0
KIMA----SviqEGGKIAVHCHAGRGRTGLIIAAYLI--------FHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLE
. .     .   | | | ||| || |||| .|   ..        .. |.   |....||.||   .|| .| ||. 
rkqeeleea...eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvy
subfamily_MKPLT_pd Subfamily MKPLT 163-231 2.2e-08 27.8 In-house 89-157 (164) alignment 
Range on Protein: 163-231
Range on HMM: 89-157/164.0
VKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFD
 | .|. |. ||.. |||  |. |.  .  |.||  . .|  .|   .. .|  .   |  .| | .|.
akfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 163-231 2.2e-08 27.8 In-house 89-157 (164) alignment 
Range on Protein: 163-231
Range on HMM: 89-157/164.0
VKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFD
 | .|. |. ||.. |||  |. |.  .  |.||  . .|  .|   .. .|  .   |  .| | .|.
akfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 146-232 2.5e-08 28.3 In-house 183-276 (288) alignment 
Range on Protein: 146-232
Range on HMM: 183-276/288.0
CAWVDFGSPPMERA-LDIVKIMASVIQEG-GKIAVHCHAGRGRTGLIIAAYLIFH----NDYT-AAKAIRLVRSQRPKTIQTRNQVKFLEEFDM
 ||.| | |  ..  |......    |.  |.| ||| || ||||  ||.  . .    .||   | ..  .| ||.  .|| .|  |. |  .
laWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Laforin_pd Subfamily Laforin 99-217 2.9e-08 26.8 In-house 32-154 (183) alignment 
Range on Protein: 99-217
Range on HMM: 32-154/183.0
KFAEAGITMVLNLQEPFEHSHCGAGVNRHGFSYS---FESFQQQGVTVCNCAWVDFGSPP-MERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAY
.. . ||| |..||  ..  .  .|..|.  .        ....|..       |. .   .|   . | .. .....| .. ||| || ||.  |.  .
dlksegitavislqtesdivknssgiyrynenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgf

LIFHNDYTAAKAIRLVRSQRPKT
| .  ... ||    . ..|| .
lqyvlgwslakvqyfllakrpvv
subfamily_DSP11_pd Subfamily DSP11 171-229 4.1e-08 27.3 In-house 114-172 (178) alignment 
Range on Protein: 171-229
Range on HMM: 114-172/178.0
QEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEE
...  |.|||  |  ||| .|  ||| ...| . .||.   . |  ...  | .| |..
dndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 135-222 4.8e-08 26.6 In-house 47-134 (148) alignment 
Range on Protein: 135-222
Range on HMM: 47-134/148.0
SFQQQGVTVCNCAWVDFGSPPMERAL-DIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKtIQTRN
 ..|.|.   ..|  |     .     ||.. .  . .||... ||.. |. |   .  ..|| ... .  .|. ||.|.|.  .. ..
aldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrry.vdpnl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 174-230 6.1e-08 26.9 In-house 229-290 (297) alignment 
Range on Protein: 174-230
Range on HMM: 229-290/297.0
GKIAVHCHAGRGRTGLIIAAYLIFHN---DY--TAAKAIRLVRSQRPKTIQTRNQVKFLEEF
  . ||| || ||.|... .  |      ..   .|  .. .|.||....|| .| ..| ..
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 147-227 6.3e-08 27.0 In-house 185-269 (307) alignment 
Range on Protein: 147-227
Range on HMM: 185-269/307.0
AWVDFGSPPMEraLDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFH------NDYTAAKAIRLVRSQRPKTIQTRNQVKFL
 | | | |...  |  . .. .|  .   . ||| || ||.| |.|  |.        |     | .. .||||. .|||  |  .|
nwpdrgvpqin..ltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylyl
subfamily_DSP10_pd Subfamily DSP10 168-234 8.1e-08 26.3 In-house 87-153 (159) alignment 
Range on Protein: 168-234
Range on HMM: 87-153/159.0
SVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYL
 . ..| .. |||.||  |   .. |||. | . .  .| ..|...||      | .  | ||.  |
earkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
subfamily_Auxilin_pd Subfamily Auxilin 134-228 1.3e-07 24.5 In-house 61-158 (166) alignment 
Range on Protein: 134-228
Range on HMM: 61-158/166.0
ESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASVIQEGGK--IAVHCHAGRGRTGLIIAAYLIFHNDYT-AAKAIRLVRSQRPKTIQTRNQVKFLE
.  ..  . | ...|     |..|  ... . . | ...  |  . |||  ||  ......|.|.| . .. . .|.||.  .|  .  .  . ..||
yrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 147-231 1.3e-07 25.6 In-house 195-283 (305) alignment 
Range on Protein: 147-231
Range on HMM: 195-283/305.0
AWVDFGSPPMERAldIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHND------YTAAKAIRLVRSQRPKTIQTRNQVKFLEEFD
 | | | |. . |  |.....      | |.||| || |||| ..    |...         . | .. .| || ..||| .|  |. .  
dwpdrgvpaadla..ilellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 133-202 1.6e-07 22.6 Pfam-A 93-162 (168) alignment 
Range on Protein: 133-202
Range on HMM: 93-162/168.0
FESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYT
.. .|| |.        | |.| .  .|.|.. .|.....  |  .||. | ||. |. |. |..  |  
ldlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsi
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 133-202 1.6e-07 22.6 In-house 93-162 (168) alignment 
Range on Protein: 133-202
Range on HMM: 93-162/168.0
FESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYT
.. .|| |.        | |.| .  .|.|.. .|.....  |  .||. | ||. |. |. |..  |  
ldlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsi
subfamily_DSP8_pd Subfamily DSP8 166-220 1.8e-07 24.8 In-house 86-139 (159) alignment 
Range on Protein: 166-220
Range on HMM: 86-139/159.0
MASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRpKTIQT
.  . .| |.. ||..||. |   .. ||.. . . .  .| | |...| .||. 
idkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr.ptisp
subfamily_PTPN3_pd Subfamily PTPN3 146-229 2e-07 25.3 In-house 179-269 (280) alignment 
Range on Protein: 146-229
Range on HMM: 179-269/280.0
CAWVDFGSPPME-RALDIVKIMASVI-QEGGKIAVHCHAGRGRTGLIIAAYLIFH-----NDYTAAKAIRLVRSQRPKTIQTRNQVKFLEE
 || | | |  .   |..|. . ..   .   . ||| || ||||..|.  . ..     ..    . .| .| ||   .|| .| ||. |
laWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 147-227 2.9e-07 24.0 In-house 181-268 (515) alignment 
Range on Protein: 147-227
Range on HMM: 181-268/515.0
AWVDFGSPPMERAL-D-IVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAY-LIFHNDYTAA----KAIRLVRSQRPKTIQTRNQVKFL
 | | |.|.  ..|   | .. |.  |    . .|| || ||||..|..   . |   | .    . .. .| .||. .||..|  |.
eWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 148-228 3.2e-07 24.6 In-house 162-257 (270) alignment 
Range on Protein: 148-228
Range on HMM: 162-257/270.0
WVDFGSPPMER----ALDIVKIMASV------IQEGGKIAVHCHAGRGRTGLIIAAYLIF-----HNDYTAAKAIRLVRSQRPKTIQTRNQVKFLE
| | | |..|     . ...|... |       .... . ||| || ||||..||   ..     ..    .. |. .| .|.. .|. .|..|| 
WpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefly
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 146-227 3.7e-07 24.5 In-house 183-272 (318) alignment 
Range on Protein: 146-227
Range on HMM: 183-272/318.0
CAWVDFGSPPME-RALDIVKIMASVI--QEGGKIAVHCHAGRGRTGLIIAAYLIFHNDY---T--AAKAIRLVRSQRPKTIQTRNQVKFL
 .| | |.|      ||.|.   ..   .. | |.||| || ||||  ||   . .      .    . .. .|.||.  .||..| .|.
tsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefi
subfamily_PTPRG_pd Subfamily PTPRG 147-228 4.3e-07 23.5 In-house 192-280 (563) alignment 
Range on Protein: 147-228
Range on HMM: 192-280/563.0
AWVDFGSPPMER-ALD-IVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIF-----HNDYTAAKAIRLVRSQRPKTIQTRNQVKFLE
 | | |.|  .   |  ..|  |.  .| | | |||.|| ||||  |.   .      .|     . .. .|.||.  .||..|  || 
kWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflh
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 148-229 9e-07 23.2 In-house 188-277 (319) alignment 
Range on Protein: 148-229
Range on HMM: 188-277/319.0
WVDFGSPPMER-ALDIVKIMASVIQ--EGGKIAVHCHAGRGRTGLIIAAYLIFHN-----DYTAAKAIRLVRSQRPKTIQTRNQVKFLEE
| | . |   .  ||..| ..   .  . | | ||| || ||||  |.   .. .          . .. .| ||.  .|. .| ||. |
WpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiye
subfamily_CG42327_pd Subfamily CG42327 172-227 1.1e-06 22.6 In-house 246-307 (319) alignment 
Range on Protein: 172-227
Range on HMM: 246-307/319.0
EGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTA------AKAIRLVRSQRPKTIQTRNQVKFL
. | ..|||  | |||||.||. . ...  ..       . .  || .| ....|..| .|.
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 145-227 1.2e-06 23.0 In-house 192-282 (298) alignment 
Range on Protein: 145-227
Range on HMM: 192-282/298.0
NCAWVDFGSPPMERA-LDIVKIMASVIQEGG--KIAVHCHAGRGRTGLIIAAYLIFHNDYT-----AAKAIRLVRSQRPKTIQTRNQVKFL
   | | | | .... ||... .    |. |   . |.| || ||.|  || . ..    .       .... .| .||...||..| .|.
ftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 148-227 1.3e-06 22.9 In-house 195-283 (319) alignment 
Range on Protein: 148-227
Range on HMM: 195-283/319.0
WVDFGSP----PMERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHN-----DYTAAKAIRLVRSQRPKTIQTRNQVKFL
| | | |    .. | .. |. . |  ..  .| ||| || ||||  |.   ...           . .| .| ||.. .|   | ||.
wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 148-228 1.4e-06 23.0 In-house 159-248 (284) alignment 
Range on Protein: 148-228
Range on HMM: 159-248/284.0
WVDFGSP----PMERALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHN-----DYTAAKAIRLVRSQRPKTIQTRNQVKFLE
| | | |    .. | .. |. . |  ..  .| ||| || ||||  |.   ...           . .| .| ||.. .|   | ||. 
wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiy
subfamily_PTPN14_pd Subfamily PTPN14 174-227 1.6e-06 22.4 In-house 230-288 (300) alignment 
Range on Protein: 174-227
Range on HMM: 230-288/300.0
GKIAVHCHAGRGRTGLIIAAYLIF----HND-YTAAKAIRLVRSQRPKTIQTRNQVKFL
  . ||| || |||| .| . |.     ||.     |... .| ||   .||  | ||.
PPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv
subfamily_PTPN9_pd Subfamily PTPN9 122-226 1.9e-06 22.1 In-house 169-281 (297) alignment 
Range on Protein: 122-226
Range on HMM: 169-281/297.0
AGVNRHGFSYSFESFQQQGVTVCNCAWVDFGSPPMERALDIVKIMASV---IQEGGKIAVHCHAGRGRTGLIIA-----AYLIFHNDYTAAKAIRLVRSQ
 . .|.   . | |.   ||     . .|. .   |.   .|| ...      .|  | ||| || ||||  |.     . |   .     ....|.|.|
teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

RPKTIQTRNQVKF
|  .||| .| .|
rafsiqtpeqyef
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 145-228 1.9e-06 22.3 In-house 144-235 (250) alignment 
Range on Protein: 145-228
Range on HMM: 144-235/250.0
NCAWVDFGSPPMERA-LDIVK-IMASVIQ-EGGKIAVHCHAGRGRTGLIIAAYLIFHNDYT-----AAKAIRLVRSQRPKTIQTRNQVKFLE
  .| | | | . .| |...| . ||  | . . . |.| || ||.|  || . ....  .       | |. .| .||.......|  |. 
fvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 137-235 2.3e-06 21.7 In-house 171-278 (315) alignment 
Range on Protein: 137-235
Range on HMM: 171-278/315.0
QQQGVTVCN-CAWVDFGSPPMERAL-DIV-KIMASVIQEGGKIAVHCHAGRGRTGLIIAAYL-IFHNDYTA----AKAIRLVRSQRPKTIQTRNQVKFLE
... ||  .   | | |..    .|  .. .. |.  ..   . ||| || ||||..|..   . .   |      . .. .|..||. .||...  |. 
esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiy

E-FDMYLH
.    .|.
davledll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 159-224 2.8e-06 21.2 In-house 202-272 (290) alignment 
Range on Protein: 159-224
Range on HMM: 202-272/290.0
ALDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAA-----YLIFHNDYTAAKAIRLVRSQRPKTIQTRNQV
.| ..... .. .  | ..||| || |||| ..|       |.   ..  .. .| .|  | ...|   | 
tlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqy
subfamily_PTPRD_pd Subfamily PTPRD 148-227 3e-06 21.2 In-house 187-273 (564) alignment 
Range on Protein: 148-227
Range on HMM: 187-273/564.0
WVDFGSPPME-RALDIV-KIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHN-----DYTAAKAIRLVRSQRPKTIQTRNQVKFL
| | | |      ||.. |. |.  .. | | ||| || ||||  |.   .        .    . ....|.||.  .||..|  |.
WPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 145-227 3.4e-06 20.7 In-house 195-280 (302) alignment 
Range on Protein: 145-227
Range on HMM: 195-280/302.0
NCAWVDFGSPP-MERALDIVKIMASVIQeggKIAVHCHAGRGRTGLIIAA-YLIF---HNDYT-AAKAIRLVRSQRPKTIQTRNQVKFL
 .|| | |.|   . ||||.|   |  .   .. ||| || |||| ..|  | |    ... |  .. .  ||. |  ..|. .|. .|
fsawpdhGapkeaytaldilkfcesykk...nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_LRR-DSP_pd Subfamily LRR-DSP 171-229 3.7e-06 20.2 In-house 192-253 (263) alignment 
Range on Protein: 171-229
Range on HMM: 192-253/263.0
Q---EGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEE
.   . | . ||| ||  |.  .. .||. ..  .  .|. || ..||.    .  .. |  
eeGrkkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkk
subfamily_PTPRN_pd Subfamily PTPRN 146-227 5.7e-06 20.2 In-house 195-284 (297) alignment 
Range on Protein: 146-227
Range on HMM: 195-284/297.0
CAWVDFGSPPMERAL-DI-VKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIR------LVRSQRPKTIQTRNQVKFL
 .| . | |.  ..| .   |.  |       | ||| .| ||||  |.  |. ..    .| |        .| |||. ..|..| .| 
lswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefa
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 146-227 7.5e-06 19.8 In-house 196-281 (305) alignment 
Range on Protein: 146-227
Range on HMM: 196-281/305.0
CAWVDFGSPPMEraLDIVKIMASVIQEGGKIAVHCHAGRGRTGLIIAAYLIFHN----DYT--AAKAIRLVRSQRPKTIQTRNQVKFL
. | | | ||    |  .......      | ||| || |||| |.|   |. .           . .. .| ||  .||.  |  |.
tewpdrgvppck..ltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 168-228 7.9e-06 20.2 In-house 206-276 (305) alignment 
Range on Protein: 168-228
Range on HMM: 206-276/305.0
SVI----QE-GGKIAVHCHAGRGRTGLIIAAYLIFHN-----DYTAAKAIRLVRSQRPKTIQTRNQVKFLE
 |     .. |  . ||| || ||||  ||  . .           .. .. .||.|.| .|| .|  || 
rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflh
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 171-229 8.4e-06 19.4 In-house 125-188 (440) alignment 
Range on Protein: 171-229
Range on HMM: 125-188/440.0
QEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAA-----KAIRLVRSQRPKTIQTRNQVKFLEE
   | . ||| || ||||.|||   |...   .        |  .|..||. .|| .|  |. |
agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe
subfamily_DSP6_pd Subfamily DSP6 171-234 9.7e-06 19.2 In-house 91-154 (158) alignment 
Range on Protein: 171-234
Range on HMM: 91-154/158.0
QEGGKIAVHCHAGRGRTGLIIAAYLIFHNDYTAAKAIRLVRSQRPKTIQTRNQVKFLEEFDMYL
..  |. |||.||  |.  .. |||. .. ..  .|  ||......     | .. | .|.  |
skkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl