Gene MTMR9 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR9
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP025_AA protein Get Run
MbreP025_AA_2-339 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR9_pd Subfamily MTMR9 6-333 2.2e-139 456.9 In-house 66-392 (393) alignment
Range on Protein: 6-333
Range on HMM: 66-392/393.0
SVSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLAGSSGKRKYEDEQMLRMVLSTAdvKQGLILDTRTSSVASTHRSKGGGLEVIDKYYGWSRKMLDIAAWP
 ....|..||||.|..|| .||..||||.|||.||||||..|||..|..||...  |.|||.|||..|.|...||||||.|. .||. |.... ..... 
asaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkkl..kkGlivdtrsksaaenarskgggietevkysqwkkasrslesva

ILADSLSKLLEACQDPSLDASKFLEKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWLHA
...|||.||||||.| .|...|||..|..|.|||.|.|.|.|||....||..|..||||||..|.|.|..|..||||..||..||..||..|.|.||..|
siqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqa

GHPFASRWSPLTRHN--KTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRHALSPEQRPRFAN
|||||||.| .....  |....|||||||||||| . ||.|.|||||..|. |...|||. ||||..|.||.|....|.|||...|..  .||....|.|
GHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqfln

PLYDAavNKGTICPSPRPQAIVLWRNLYC-W
|||.|  |. .|.|| .||...||..||. |
plyea..naeviwpsvapqslelWselylrw

0040695 (Phosphotyrosine protein) phosphatases II 6-332 2e-93 307.0 In-house 59-383 (388) alignment
Range on Protein: 6-332
Range on HMM: 59-383/388.0
SVSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLAGSSGKRKYEDEQMLRMVLS-TADVKQGLILDTRTSSVASTHRSKGGGLEVIDKYYGWSRKMLDIAAW
.|...|..||.| |.. ||.... ||||.||| | ...| .|||..|...|. . . ...||.|.|    | . | .||| | .| |. .   .|.|  .
rvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipni

PILADSLSKLLEACqDPSLDASKFLEKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWLH
  . .|| |||.|| ... | ...| .|. |.||....  |..|  .| .|.... .|.||.| |.|.|.....|||| .|||.||||||. |.||||| 
hvvreslqklldac.lnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWls

AGHPFASRWSPLT-RHNKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRHALSPEQRprFAN
.||.||.|.. |   .. .|..||||||||||.| . ||  |||||| .|. |.  .|||.||||....|  |   .. ..|...|.. ||....  | |
fghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkse..fln

PLYDAAVNKgTICPSPRPQAIVLWRNLYC
||||   .   . ||.... ..|| ..|.
plYdpssle.vllpslsvldlllWleyyl

subfamily_MTMR1_pd Subfamily MTMR1 5-332 2e-90 295.9 In-house 58-384 (389) alignment
Range on Protein: 5-332
Range on HMM: 58-384/389.0
RSVSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLAGSSGKRKYEDEQMLRMVLSTADVK-QGLILDTRTSSVASTHRSKGGGLEVIDKYYGWSRKMLDIAA
. |...|..||.|.|..|.....  .||. |||.| ||||. |||..|...|.. . . . |||| |.|. | . . ||.| |  ..|.  .   |||. 
kkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihn

WPILADSLSKLLEACQdPSLDASKFLEKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWL
  .. .||.|| |... |..| .|.| .|....||. ... |..| . |...|.|.. |.|| | | | |  ...||.| .|.|.||.|||  |.|||||
ihvvReslkklkelvl.pnvddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWl

HAGHPFASRWSP-LTRHNKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRHalSPEQRPRFA
  ||.|..| .     ....||.|||| |.|||.|   ||  ||||||.||. |  ..|||.||||. ..|. | .|....||  .| .    ... .| 
sfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkekvkektvslwsy..vnsskeeft

NPLYDAAVNKGTICPSPRPQAIVLWRNLYC
||||.  ..|  . |    . . ||.. |.
nplyaeelekkvlypkaslrrlelWkeyyl

Myotubularin-like phosphatase domain 6-277 2e-90 296.1 Pfam-A 73-351 (353) alignment
Myotubularin-like phosphatase domain 6-277 2e-90 296.1 In-house 73-351 (353) alignment
subfamily_MTMR6_pd Subfamily MTMR6 7-332 7e-82 267.8 In-house 71-393 (397) alignment
Range on Protein: 7-332
Range on HMM: 71-393/397.0
VSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLAGSSGkRKYEDEQMLRMVLSTADVKQGL-ILDTRTSSVASTHRSKGGGLEVIDKYYGWSRKMLDIAAWP
 ||.|  ||.|.| .|| ...  . |. |||.| |  |  |||..|... ..    . | ..|||    | . ...| | |  |.|     ....|    
sskfrskgrlPvlsylhkeneaaicrcsqplsgfsa.rcledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienih

ILADSLSKLLEACQDPSLDASKFLEKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWLHA
.. .||.||||...  | . |.||. |..|.||  ..  | |..     ...|.. |.|| | | | |. |..||.| .|||.||..||  |.|||||  
vmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsf

GHPFASRWSPLTRhNKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRHALspEQRPRFANPL
|| | .|   |   .. | .|.|. ||.||.|   ||  ||||||.||.||  . ||| ||||.|.||  |   .| ..|   | . |  |..  ..|||
GhkfsercGllde.dskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayll..erkddylnpl

YDAAVNKGTICPSPRPQAIVLWRNLYC
|.|  .|... |. .|.|. |||.||.
ykaetekevlkpdtapaalklwralyn

subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 6-332 2.4e-77 252.8 In-house 68-400 (404) alignment
Range on Protein: 6-332
Range on HMM: 68-400/404.0
SVSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLAGSSGKRKYEDEQMLRMVLS-TADVKQGLILDTRTSSVASTHRSKGGGLEVIDKYYGWSRKMLDIAAW
.|...|..||.|.|.. |....  . || ||| | ...|  |||... .. . .. ... .|||.|..  |.. ..|| | | |..|.. . ..| |.  
kvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnieni

PILADSLSKLLEACQDPSLDASKFLEKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWLH
  | .|| || .|...   . ...|..|. |.||  ..  |... ..|. .|.|...|.|| | | | |. ...|.|| .|||.||.|||  |.||||| 
helreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewls

AGHPFASRWSPLTRHNKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRhALSpEQRPRFANP
 || ||.| .  | ... ||.|.|| |.|||||   ||   |||||.||...  ..||| ||||. |.|  |  ..| |.|  .|   |. ...  . ||
fGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWa.lle.ankseylnp

LYDAAVNK--GTICPS-----PRPQAIVLWRNLYC
|| .  ..   .|  |       .. | ||...|.
lyilekkeqkenitssessssadikliklWseyyl

subfamily_MTMR3_pd Subfamily MTMR3 60-332 3.2e-65 213.6 In-house 171-440 (442) alignment
Range on Protein: 60-332
Range on HMM: 171-440/442.0
DVKQGLILDTRTSSVASTHRSKGGGLEVIDKYYGWSRKMLDIAAWPILADSLSKLLEACQdPSLDASKFLEKLNASNWLSTVRDALSAALQAVTCLEHEQ
. |. ||.| |. . | . |.||||.|. . |     . |..|    .  |. .| . ..  | | |..| .|.. .||  .   | ||.. |. ...|.
ekkkllivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkeg

QPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWLHAGHPFASRWSPLTR-HNKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYM
.||.|| | | | |  .||||.| .|||.||||||  |||.|||. || || | .     ... ||.|||| .||.|.|   || ..|||||.||. |  
rpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvq

QSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRHALsPEQRpRFANPLYDAAvNKGTICPSPRPQAIVLWRNLYC
 .|||.||||....|  |  |.. ..|   |.    .... .. | ||.   ..  ..|. . ... ||...| 
htysclfGtflansekereeekvkertlsvWsllr.akek.eyrnllykek.teavllpavsvrelklwsevyl

subfamily_MTMR10_pd Subfamily MTMR10 123-309 1.2e-51 167.6 In-house 150-339 (380) alignment
Range on Protein: 123-309
Range on HMM: 150-339/380.0
LDASKFLEKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWLHAGHPFASRwSPLTRHNKT
    |.| .|. ..|| .|| .|| | .|| ........|..  | | |. |.|  |||| .||..||..||..|..|||  ||||| .|    .  ...
tlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldr.lghikpsek

ERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAE----QLDKKTRCFWRHALSPEQRPRFANPLYDAA
...||||||||||.|   || ..|||.|.||. |.  |.|..|.||. ..|. |  .    ..   .. ....  . .. . . ..||   
sespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliakselkendllkdeldyrqglyaei

subfamily_MTMR5_pd Subfamily MTMR5 108-327 5.8e-51 165.8 In-house 242-475 (483) alignment
Range on Protein: 108-327
Range on HMM: 242-475/483.0
ADSLSKLLEACQDPSL--DASK--FLEKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEKEWL
  |. ||| ||       .|..  ||.....|.||. ..  |  .  .|  |. ..  |.|    | |.| .|..|||| .|||.||||||. |||||||
kasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWL

HAGHPFASRWSPLTRHNKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQL----------DKKTRCFWRHAL
  || |. | .  . ....  ||||| |||||.|   ||  |||||. .|  |   | |. | ||. |.|  |  ..|          .| ... | .  
afGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyid

SP-EQRPRFANPLYDAaVNKGTICPSPRPQAIVLW
   .. | | | ||.   .. .. || .  .. .|
rqhkrspifynflysp.desevlrPssnvsslkvW

subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 8-331 4.4e-47 152.7 In-house 76-401 (405) alignment
Range on Protein: 8-331
Range on HMM: 76-401/405.0
SKYRQNGRFPMLCFLHPKTKMPLLRSGQPLAGSSGKRKYEDEQMLRMVLSTADVKQGLILDTRTSSVASTHRSKGGGLEVIDKYYGWSRKMLDIAAWPIL
  .| .|| | | .  |...  . |  ||| |    |  |||     .  .|  |   ..|.|    | .  ..| |.| | .|      ...|    ..
fsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslalsapsktlylidarpklnaiantangagfenihnypncklvfmnipnihvi

ADSLSKLLEACQDPSLDA-------SKFLEKLNASNWLSTVRDALSAALQAVTCLeHEQQPVVVHGSHGTDITCIVVALAQLYMDPYFRTLEGFCKLVEK
  || ||  | .  . |         .|   .. . |.| ..  | ||  .   .    . ..|| | | | |  . .|.|. .|||.||. ||  |.||
rksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliek

EWLHAGHPFASRWSPLTrHNKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRHALSpeQRPR
|||  || |. |   |   |. ||.|.|  ||||..|   ||   |||  |.|. .  . .|| .|||. .||  |  .|.  ||   |       .  .
ewlsfghkfslrlghlp.gneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnl..nvnk

FANPLYDAAvNKGTICPSPRPQAIVLWRNLY
| || |.   .  .| |    ... ||.  |
flnpyynpq.diqsikpklysrclelwkacy

subfamily_pats1_pd Subfamily pats1 130-213 8.3e-15 46.2 In-house 371-457 (691) alignment
Range on Protein: 130-213
Range on HMM: 371-457/691.0
EKLNASNWLSTVRDALSAALQAVTCLEHEQQPVVVHGSHGTDITCIV---VALAQLYMDPYFRTLEGFCKLVEKEWLHAGHPFASRW
...  | |. .|.  |.||..  . |.. .  ..   . . .|.  .    .|||. .||..|||.||  |.|||||. |.||. . 
keieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskin

subfamily_pats1_pd Subfamily pats1 225-311 1.8e-14 45.0 In-house 553-637 (691) alignment
Range on Protein: 225-311
Range on HMM: 553-637/691.0
APVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAEQLDKKTRCFWRHalSPEQRPRFANPLYDAAVN
.|.|. ||| |.| . .|   ||||||.|. |  .|.|  ||.|. .    .. ... |... .|        . || | ||  . .
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsf..inqnksrfinllykhsas

subfamily_MTMR3_pd Subfamily MTMR3 6-60 5.3e-08 25.1 In-house 76-130 (442) alignment
Range on Protein: 6-60
Range on HMM: 76-130/442.0
SVSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLAGSSGKRKYEDEQMLRMVLSTAD
.|...|  .|.| . . | |..  | |..||  |  | |  |||..|. .  .. 
kvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaiakaca