Gene DSP1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP004_AA protein Get Run
NvecP004_AA_224-368 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 221-367 3.6e-65 213.0 In-house 11-158 (163) alignment 
Range on Protein: 221-367
Range on HMM: 11-158/163.0
SNSVNEPVE-LLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSA
.... .||| .|..|||||| .||....||.|||.||.|||....|.||| |.||.....|. .||| ..|||.  |||.||...|.||.|||||||||.
klklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRss

TICLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQTMR
|.|||||... ...|.||...||.|||.||||..|..|||.||.....
tlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
subfamily_DSP6_pd Subfamily DSP6 220-364 2.7e-54 177.0 In-house 7-153 (158) alignment 
Range on Protein: 220-364
Range on HMM: 7-153/158.0
HSNSVNEPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFED--SFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISR
.... . |||.||.|||||. .|| ..|||.|.|. ..||  |.||.||.  ...|. ||..| .....  .| ||  |||  . .   ||||| |||||
kkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisr

SATICLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
| |..||||...|.. |..||..||||.| ||||||||||||..| .
svtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_DSP10_pd Subfamily DSP10 222-364 4.3e-54 176.7 In-house 9-152 (159) alignment 
Range on Protein: 222-364
Range on HMM: 9-152/159.0
NSVNEPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFED-SFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSAT
    . ...||.|.||||  |.  |.|.||.|.|..||  ..||.||. ...|| ||| ||.. ..   ||||  ||. .. .| |||||||||||||||
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsat

ICLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
. .|||. .||  | .||..||..|..||||.|||||||..| .
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
PTPc_motif_SM00404 227-363 8e-46 150.4 In-house 2-139 (140) alignment 
Range on Protein: 227-363
Range on HMM: 2-139/140.0
PVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNT-FEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAY
| . ||||||||. .|.....|| |||....||......|  . .|... ||.||. ....  ...... ||......||.||||||||.|||||...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
|... .. |.||||.||.||. ||||.||. ||. ||.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP8_pd Subfamily DSP8 225-366 4.6e-45 147.0 In-house 13-155 (159) alignment 
Range on Protein: 225-366
Range on HMM: 13-155/159.0
NEPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNT-FEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICL
 .| ..|..|||||. ..  ...|..|||| ..|.|.. |.. .     .  .|| |.|. ..  ||...  ||| .|.. ||||||. ||||||||. .
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQTM
||.. .|.. |||||..||..| .||||.||.||||.|| . .
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
DSPc Dual specificity phosphatase, catalytic domain 234-364 8.7e-43 140.4 Pfam-A 1-133 (133) alignment 
Range on Protein: 234-364
Range on HMM: 1-133/133.0
LYLGSELHASrRDVLKRLGISAIVNVSRNIPNT---FEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISRL
|||||. .||  ..|. |||....||....||.    . ...|  |||.|. ...|  ..|||  ||......|..||||||||||||||...|||... 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
|..|.||||.||.||| ||||..|..||| ||..
nlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 234-364 8.7e-43 140.4 In-house 1-133 (133) alignment 
Range on Protein: 234-364
Range on HMM: 1-133/133.0
LYLGSELHASrRDVLKRLGISAIVNVSRNIPNT---FEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISRL
|||||. .||  ..|. |||....||....||.    . ...|  |||.|. ...|  ..|||  ||......|..||||||||||||||...|||... 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
|..|.||||.||.||| ||||..|..||| ||..
nlslneAyefvkerrskispnagflrqLleyerk
subfamily_DSP14_pd Subfamily DSP14 228-365 5.8e-42 137.3 In-house 8-144 (157) alignment 
Range on Protein: 228-365
Range on HMM: 8-144/157.0
VELLPHLYLGsELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLI
... |.|.|.    |.....||. .|..|.||....|||  ... .  .||.|. .|..  .|.|.|  |..||..||..|||| ||.||||..|||||.
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

SRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQT
   .  | |||..||..|..|.||  |  || .||.. 
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0044763 (Phosphotyrosine protein) phosphatases II 225-367 1.5e-41 137.3 In-house 21-172 (178) alignment 
Range on Protein: 225-367
Range on HMM: 21-172/178.0
NEPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDS---------FTYKTIPVDDTYNADIGVWFEEAAGFIDSVK-ASGGRVLVHCQAG
. ..| ||.|||||  .|. .. ||.|||..|||.. .... |...         ..|. ||..|  . |.  .|.|.  ||...   .||.|||||.||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

ISRSATICLAYLISRLNFRLDEAYEYVKKRRSvISPNFNFMGQLLHYETQTMR
..||.|...|||. .|.. |.||.|.|..||. |.||.... ||. .| . . 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP19_pd Subfamily DSP19 228-365 2e-41 135.9 In-house 13-150 (152) alignment 
Range on Protein: 228-365
Range on HMM: 13-150/152.0
VELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLI
.|. |.|||||   |. .. ||. .|  |.||. ..||.| . |||..|.. |. ..|.  ...|| .||.... . |.|||||.||.||||.. .|||.
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

SRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQT
.. . .| ||.|.|.. |  |.||  |. || .||.. 
kkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_Slingshot_pd Subfamily Slingshot 224-363 5.1e-40 130.6 In-house 16-155 (169) alignment 
Range on Protein: 224-363
Range on HMM: 16-155/169.0
VNEPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICL
.... ..  |.|||||  ||  . ||. |.. |.||...| | |...|.|..| | |. ..|.  ...|.  ||. .|..| .|||||. |.||||.. .
ldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvi

AYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
|| . . .. |.||.||||.||||| || .|. || .|| 
ayamkeyglsleealeyvkerrsvikPnkgflkqleeyeG
0048076 (Phosphotyrosine protein) phosphatases II 227-364 9.1e-37 121.3 In-house 4-141 (145) alignment 
Range on Protein: 227-364
Range on HMM: 4-141/145.0
PVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYL
| | ||.|||||  .|.... ||.||| ...|....... ..  ..|  .|..|    |.  ...|.  ||... ..||.|||||.||..|..|...|||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

ISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
. .|.. |.||.|.|...|. . ||.... .|. .|..
mlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_MKPLT_pd Subfamily MKPLT 230-365 2e-36 119.0 In-house 25-160 (164) alignment 
Range on Protein: 230-365
Range on HMM: 25-160/164.0
LLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISR
|  .||||   ||  . ||| | |  |||||..  . |  |. | .. |.|. .  .. ..| || |. .   |||||||||. | |||... .|.||. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

LNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQT
  . |.|||||.|.|||...||  |. || ..|  .
kgwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 230-365 2e-36 119.0 In-house 25-160 (164) alignment 
Range on Protein: 230-365
Range on HMM: 25-160/164.0
LLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISR
|  .||||   ||  . ||| | |  |||||..  . |  |. | .. |.|. .  .. ..| || |. .   |||||||||. | |||... .|.||. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

LNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQT
  . |.|||||.|.|||...||  |. || ..|  .
kgwtlkeayeylkerrsivapnrGflkqlakfeeli
0048179 (Phosphotyrosine protein) phosphatases II 227-363 1.9e-35 117.0 In-house 4-142 (144) alignment 
Range on Protein: 227-363
Range on HMM: 4-142/144.0
PVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSF--TYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLA
|.| ||.|||||  .|.. . ||.|||....|.. . ...|.  .  .|  .|..|    |.  ...|.  ||... ..||.|||||.||..|..|...|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
||. .|.. |.||...|..||. . ||.... .|| ||.
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP12_pd Subfamily DSP12 229-371 3.7e-35 115.6 In-house 4-149 (155) alignment 
Range on Protein: 229-371
Range on HMM: 4-149/155.0
ELLPHLYLGSELHASRRDVLKRLGISAIVNVSRN-IPN-TFEDSFT-YKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAY
..|| ||||.  .. . . || |.|.... | .. .|. . . . . .|.|...|. ..||  ...||  ||..  . .| ||||||||.|||.||..||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQTMRLDNE
|. . .. |..|.. ||. .. |.|| .|. ||  .|   ...|..
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdts
subfamily_DSP15_pd Subfamily DSP15 229-372 5.4e-35 114.7 In-house 4-147 (151) alignment 
Range on Protein: 229-372
Range on HMM: 4-147/151.0
ELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDsFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLIS
..|| ||||    .. .. ||.  |. |..|. |  . ..| ..||.|...|| .|..  .|.|.  || . .  .. ||||| ||.|||.|.. |||..
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

RLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQTMR-LDNEL
 ...   .| | .|..|||  ||| |  || .||..... . ..|
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkql
0043147 (Phosphotyrosine protein) phosphatases II 222-368 1.3e-34 114.8 In-house 14-163 (172) alignment 
Range on Protein: 222-368
Range on HMM: 14-163/172.0
NSVNEPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRN---IPNTFEDSFTYKTIPVDDTYNAdIGVWFEEAAGFIDS--VKASGGRVLVHCQAGIS
. .  | ........... .|. .. ||.|||..|||. .     .. ..  ..|  .|..|     .  ...|.  |||.  .. .||.||||| ||..
dlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvg

RSATICLAYLISrLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQTMRL
|..|...|||.  |.. |.||...|...|. ...|.... .|...| . ..|
Rtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 233-364 1.5e-34 112.7 In-house 14-146 (148) alignment 
Range on Protein: 233-364
Range on HMM: 14-146/148.0
HLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFT-YKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISRLN
.|.|||  .|.  ..|| ||...||| ... .|....    |  ...||  . |.   ||... |.. .|. |.|||||.| |.|||. . |..||   .
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

FRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
  | ||...|| .|  . ||  |. || ..| .
vslkealalvkskrryvdpnlgfLkqLaeleqa
0041856 (Phosphotyrosine protein) phosphatases II 226-365 1.2e-33 111.6 In-house 18-172 (182) alignment 
Range on Protein: 226-365
Range on HMM: 18-172/182.0
EPVELLPHLYLGSELH--------------ASRRDVLKRLGISAIVNVSrnIPNTFEDSF-----TYKTIPVDDTYNADigvwFEEAAGFIDSVKASGGR
 . . ...|||||  .              |.  . ||.|||..|||..   .. . . .     .|. .|..|    |    ..|.  ||. |...||.
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKRRS--VISPNFNFMGQLLHYETQT
||||| ||..|..|...|||. .|.. |.||...|..||.  ||.||..|. ||. .| . 
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_DSP3_pd Subfamily DSP3 225-367 1.7e-33 109.5 In-house 9-159 (162) alignment 
Range on Protein: 225-367
Range on HMM: 9-159/162.0
NEPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRN-I------PNTFED-SFTYKTIPVDDTYNADIGVWFEEAAGFIDS-VKASGGRVLVHCQAGI
.|  |  |.||.| |  |. .. ||.|||  ..| ..  .      .. ..| ...|  ..|||. ..|. ..||.|| |||. .. . |.|||||..|.
kevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSATICLAYLISRLNFRLDEAYEYVKKRRSvISPNFNFMGQLLHYETQTMR
|||||. ||||. | .. | || . |.|.|. | ||  |. || ..... .|
sRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelkr
0049772 (Phosphotyrosine protein) phosphatases II 228-366 9e-33 109.7 In-house 155-274 (314) alignment 
Range on Protein: 228-366
Range on HMM: 155-274/314.0
VellphlylgSELHASRRDVLKrlgisaivnvsRNI--PNTFEDS-FTYKTIPVDDtYNADIGVWFEEAAGFIDSVkASGGRVLVHCQAGISRSAT-ICL
          .|..|.. . ||           . .  |. ||.  ..|. |||.| ..|..  .|.|.  ||...   ||.|||||.||..|..| ...
g.........neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvva

AYLISRLNFRLDEAYEYVKKRRSvISPNFNFMGQLLHYETQTM
|||...|.. |.||.|.|...|. |.||..|. ||..|| . .
aylmkllgvsleealedvrlkRp.inpnpgfieqleqyefile
PTEN_1 221-365 2.5e-32 107.3 In-house 33-191 (196) alignment 
Range on Protein: 221-365
Range on HMM: 33-191/196.0
S--NSVNEPVELLPHLYLGSELHASR-RDVLKRLGISAIVNVSRNIPN---------TFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKA--SGGR
.   |.. . |. ..||.||...... .| ||  || ..||.|   ..          |.  ..|. .|..|    ..  .|.... ||.....  .|. 
gkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnv

VLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQT
|||||.||..||.|.. |||... ..  ||| |.|...|....||  .. .||.|. ..
VlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
subfamily_LRR-DSP_pd Subfamily LRR-DSP 227-364 1.3e-31 103.7 In-house 120-257 (263) alignment 
Range on Protein: 227-364
Range on HMM: 120-257/263.0
PVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDSFTYKTI-PVDDTYNADIGVWFEEAAGFIDSVKASGGrVLVHCQAGISRSATICLAY
| |....|.||.   |  . .|| ||.. |.    ..   | . | | .|  ..|. .|||  .|||   ||.. . .|| |||||.||.|||.|. ..|
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisy

LISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
|. . .... ||.. |.|.|. | ||  |. ||. || .
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
0049260 (Phosphotyrosine protein) phosphatases II 226-363 4.3e-31 103.0 In-house 7-147 (152) alignment 
Range on Protein: 226-363
Range on HMM: 7-147/152.0
EPVELLPHLYLGSELHASRRDVLKRLGISAIVNVSRNIPNT---FEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDS-VKASGGRVLVHCQAGISRSATI
 | | ......|.. .|.  . ||.|||..||.. .  ...   .|  ..|. .|..| .  |.  .....  ||.   . .||.||||| ||..|..|.
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

CLAYLISrLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
..|||.  |.. |.||...|...|... ||.... .|. .|.
vaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0046846 (Phosphotyrosine protein) phosphatases II 228-364 8.1e-30 99.3 In-house 13-171 (176) alignment 
Range on Protein: 228-364
Range on HMM: 13-171/176.0
VELLPHLYLGSEL----------HASRRDVLKRLGISAIVNVSRNI-------PNTFED----SFTYKTIPVDDTYNADIgVWFEEAAGFIDSVKASGGR
......|.|||            .|.  . ||.|||.|.||.   .       || ...    ...|. .|..|    |.  ...|.  ||...  .||.
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggp

VLVHCQAGISRSATICLAYLISR-LNFRLDEAYEYVKKRRS-VISPNFNFMGQLLHYETQ
|||||.|||.|..|...|||. .  .. ..||...|...|.  . ...... .| ..| .
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0045098 (Phosphotyrosine protein) phosphatases II 223-364 1.2e-28 95.7 In-house 18-270 (278) alignment 
Range on Protein: 223-364
Range on HMM: 18-270/278.0
SVNEPVELLPHLYLGSEL-----------------------------------------HASRRDVLKRLGISAIVNVS---------------------
. . | | .|.||||.                                           .|.  . |. |||..||..                      
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------RNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKA--------------SGGRVLVHCQAGI
                                .... .   . |...|  .. . .|  .| |.  ||... .              |||.|||||.||.
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSATICLAYLISRL---NFRLDEAYEYVKKRRSV-ISPNFNFMGQLLHYETQ
.|..|...|||. .|   .. |.||.......|   . .|.... .| ... .
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_STYXL1_pd Subfamily STYXL1 226-365 1.7e-28 92.8 In-house 10-153 (157) alignment 
Range on Protein: 226-365
Range on HMM: 10-153/157.0
EPVELLPH-LYLGSELHASRRDVLKRLGISAIVNVSRN---IPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATI
 |||.||. |||| . .|  . . | | . | |||| .   . .. .|     .|.|.|. .||.   ..||  ||.. | .|  |||  . ||||||..
yPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaav

CLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQT
 .|||.   .. | .||.|.|| .. . || .|. || ..| | 
iiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0040439 (Phosphotyrosine protein) phosphatases II 229-363 4.6e-28 93.9 In-house 31-243 (249) alignment 
Range on Protein: 229-363
Range on HMM: 31-243/249.0
ELLPHLYLGSELHASRRDV------------------------LKRLGISAIVNVSRNIPN---------------------------------------
. || |.|..  .||  |.                        |..|||..||....  ..                                       
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

----TFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKA------SGGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISP
     . .|.|.. |.. |    ..  .||..  ||. |.       .||.||||| ||..|..|...|||.      .|.. |.||.......|. . .
ltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NFNFMGQLLHYET
|.... .|. .. 
npeqyrflyeall
0036282 (Phosphotyrosine protein) phosphatases II 228-362 6.3e-28 93.0 In-house 13-166 (174) alignment 
Range on Protein: 228-362
Range on HMM: 13-166/174.0
VELLPHLYLGSELHAsRRDVLKRLGISAIVNVSRNIPNT---------------FEDSFTYKTIPVDDTYNADIGVwFEEAAGFIDSVKAS--GGRVLVH
.. .|.|..|.  .|   . ||.|||...|.. . ...                 .  ..|. .|..|    |. . ..|.  |.... ..  || ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CQAGISRSATICLAYLISRLNF-RLDEAYEYVKKRR---SVISPNFNFMGQLLHYE
| ||..|..|...|||. |. . .|..|...|...|   . . ...... .|  .|
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
subfamily_STYX_pd Subfamily STYX 226-363 1.1e-27 90.1 In-house 11-155 (166) alignment 
Range on Protein: 226-363
Range on HMM: 11-155/166.0
EPVELLPHLYLGSEL--HASRRDVLKRLGISAIVNVSRNIPN-----TFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRS
|  |.|| |.||       |. .|||. ||. || . .||        |.|.| |  . | |.   .|  .. .  .|||.   .||.|||| .||||||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

ATICLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
|.. .||..    ..  ||. ||..||  |.||  |. || .||.
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0037934 (Phosphotyrosine protein) phosphatases II 228-363 4.2e-26 87.4 In-house 40-239 (243) alignment 
Range on Protein: 228-363
Range on HMM: 40-239/243.0
VELLPHLYLGSE--------LHASRRDVLKRLGISAIVNVSRNI---------------------------------------------PNTFEDSFTYK
.. .|.|....          .||  . |..|||..||.. . .                                             .. .   . | 
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

TIPVDD----TYNADIGVWFEEAAGFIDS-----VKASGGRVLVHCQAGISRSATICLAYLISRL-NFRLDEAYEYVKKRRSV-ISPNFNFMGQLLHYET
 .|. |    .  .|.  ...|.  ||..     .  |||.||||| ||..|..|...|||. .| .. |.||.......|.  . ...... .| ... 
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 246-363 5.6e-26 87.4 In-house 125-301 (307) alignment 
Range on Protein: 246-363
Range on HMM: 125-301/307.0
DVLKRLGISAIVNVSRNIPNTF----------------------------EDSFTYKTIPVDDT-----------------YNADIGVWFEEAAGFIDSV
  |...|...||.... .....                            .|..|. |..| |.                  . ..  .|||.  ||. |
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KA------SGGRVLVHCQAGISRSATICLAYLISRLN--------FRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
..      .||.||||| ||..|..|...|||. |.         . |.||.......|. . .|.... .| ... 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0051082 (Phosphotyrosine protein) phosphatases II 230-361 9e-25 82.4 In-house 11-149 (151) alignment 
Range on Protein: 230-361
Range on HMM: 11-149/151.0
LLPHLYLGSELHASRRDVLKRLGISAIVNVSRNI-----PNTFED-SFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKAS-GGRVLVHCQAGISRSATIC
. ..||... ..|   . ||.|||..|||.         |. ... ..... ||..|. . .. ..|.... |.. . .  .| ||||| ||..|..|..
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

LAYLISrLNFRLDEAYEYVKKRRS-VISPNFNFMGQLLHY
..||.  |.. |.||.|.....|  |. ||  |. ||...
alylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0042113 (Phosphotyrosine protein) phosphatases II 229-363 2.5e-24 81.4 In-house 49-240 (245) alignment 
Range on Protein: 229-363
Range on HMM: 49-240/245.0
ELLPHLYLGSELHASRRD----VLKRLGISAIVNVSRNIPNTFED----------------------------------------------SFTYKTIPV
.  |......  ...  .     |..|||..||....  .. ...                                               ..|  .|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

DDTYNADIGVWFEEAAGFIDSVKA--SGGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
.|   .|.  .....  |.... |  |.|.||||| ||..|..|...|||.     ..|.. |.||.......|. . ...... .| ... 
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 234-364 4.3e-24 78.3 In-house 6-140 (145) alignment 
Range on Protein: 234-364
Range on HMM: 6-140/145.0
LYLGSELHASRRDVLKRLGISAIVNVSRN----IPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISR
|| || |||.   .|. |||| |||..        ..  .|..   |  .|    |.   |.| . |||  |  |  |.||| ||.||| |. .|.|.  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
 |. | ||   |. .|    || .|. .||. | |
cnmtlseaarqvrsnrllaypnvtflknllnlekq
0040438 (Phosphotyrosine protein) phosphatases II 247-366 3e-23 78.0 In-house 105-276 (317) alignment 
Range on Protein: 247-366
Range on HMM: 105-276/317.0
VLKRLGISAIVNVSRNIPNT---------------------------FEDSFTYKTIPVDDTYN--------------ADIGVW--FEEAAGFIDSVKAS
 ....|.. ||.. .  ..                             ....|. |..| |...               | ||   ...   |.. |...
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQTM
    || ||||| ||..|..|...|||.      . .. ..||.......|. . ...... .|  .. . .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 233-365 1e-22 74.2 In-house 9-152 (154) alignment 
Range on Protein: 233-365
Range on HMM: 9-152/154.0
HLYLGSELHASRRDVLKRLGISAIVNVSRNIPNTFEDS---------FTYKTIPVDDTYNADIGVWFEEAAGFIDSVK--ASGGRVLVHCQAGISRSATI
.||..|   |  .  |.   |  |.||.  |.| | |          . |  . . |  | ||   .. |  |||.       ..||||...|.||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

CLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQT
 ..||. .|.  | .|.| .|. | .|.||  |. ||  .| . 
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
0036941 (Phosphotyrosine protein) phosphatases II 225-364 6.7e-22 73.6 In-house 17-275 (297) alignment 
Range on Protein: 225-364
Range on HMM: 17-275/297.0
NEPVELLPHLYLGSELHASRRDVLK----------------------------------------------------------RLGISAIVNVSRNIPNT
 |  ||||.|.|||  .|.. . |.                                                           .... ||.... ... 
kefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelg

F-------------------------------EDSFTYKTIPVDD--------------TYNADIGVW--FEEAAGFIDSVKA------SGGRVLVHCQA
.                               .|..|. |. | |              |   | ||   ...   ||. |.       |||.||||| |
rekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsa

GISRSATICLAYLI--------SRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
|..||.|...|.|.         . .. . ||. .....|  . ...... .| ... .
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0051429 (Phosphotyrosine protein) phosphatases II 232-367 8.7e-22 73.5 In-house 21-226 (272) alignment 
Range on Protein: 232-367
Range on HMM: 21-226/272.0
PH-LYLGSEL---HASRRDVLKRLGISAIVNVSRNIPNTFED------SFTYKTIPVDDTYNADIGVWF-------------------------------
|. ||... .    |   . ||.|||..||.. .     ...       ..|  .|. |..  .| ...                               
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------EEAAGFIDSVKAsGGRVLVHCQAGISRSATICLAYLISrLNFR--------------LDEAYEYVKKRRSVISPNFNFMGQLL
                 |.   ... . . ||.||||| ||..|..|.....|.  |..               |.||.|.....|  . ..  .. .|.
evmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

HYETQTMR
... . .|
eallellr
0039614 (Phosphotyrosine protein) phosphatases II 247-363 4.5e-21 71.0 In-house 120-286 (297) alignment 
Range on Protein: 247-363
Range on HMM: 120-286/297.0
VLKRLGISAIVNVSRNIPNTF-------------------------EDSFT-----------------YKTIPVDDTYNADIGVWFEEAAGFIDSVKA--
 ....|...||.. . ...                           .| .|                 .  ..  |    ..   . |.  ..... |  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-SGGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYET
 .||.||||| ||..|..|...|||.     .. .. ..||.......|. . ...... .| ... 
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0038934 (Phosphotyrosine protein) phosphatases II 253-364 5.4e-19 64.0 In-house 57-175 (194) alignment 
Range on Protein: 253-364
Range on HMM: 57-175/194.0
ISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGV--WFEEAAGFIDSV-----KASGGRVLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKRR
. ...... . .    . |.   | . . .  | |.   .|    |.| |     . .|| |.||| ||..|..|.. |||| ||.. ..||..... .|
lglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR

SVISPNFNFMGQLLHYETQ
  . || ... .|| .  .
pgaipnqdyleallkryke
0043336 (Phosphotyrosine protein) phosphatases II 248-362 4.2e-18 61.2 In-house 108-273 (278) alignment 
Range on Protein: 248-362
Range on HMM: 108-273/278.0
LKRLGISAIVNVSRNIPNTF-----------------------------------------------EDSFTYKTIPvDDTYNADIGVWFEEAAGFIDSV
.. ||.. ||.. .   .                                                    . |. .| |..   ..   ..    ... .
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreal

KASGGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYE
. |.| ||||| ||..|..|....||.     ..... |.||.......|  . ...... .| ...
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_MSG5_pd Subfamily MSG5 231-364 5.7e-17 55.3 In-house 30-159 (165) alignment 
Range on Protein: 231-364
Range on HMM: 30-159/165.0
L-PHLYLGSELHAsrRDVlkrLGISAIVNVSRNIPNTFEDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISR
| ..||| || .   ...   | .  ..||...|..      . |   .. .... |   . . .  | . .. . ..||||| |.||||.. .||..  
lpeklylysepkl..kel...lsfdlvinvakeindlellvpavkyyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimky

LNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
 |. | .||. .| .   |||.. .. ||. .|. 
ynlslrdaydklksvaddispsiglifqlmeweva
subfamily_PTPMT1_pd Subfamily PTPMT1 276-364 3.4e-15 50.9 In-house 79-167 (171) alignment 
Range on Protein: 276-364
Range on HMM: 79-167/171.0
IPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKRRSVISPNFNFMGQLLHYETQ
... |  .|      |..  ||..|. .| || |||.|| .||||.  .||. . .. ..|| ...||.|. |  . . . .| .||..
latvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
0047943 (Phosphotyrosine protein) phosphatases II 285-358 4.4e-14 48.0 In-house 178-264 (273) alignment 
Range on Protein: 285-358
Range on HMM: 178-264/273.0
DIGVW--FEEAAGFIDSVKA------SGGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISPNFNFMGQL
| ||   .|.   ||. |.       |.| |.||| ||..|..|.....|.      . .. ..||. .....|  . ...... .|
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 271-353 3.6e-12 41.8 In-house 187-273 (288) alignment 
Range on Protein: 271-353
Range on HMM: 187-273/288.0
FTYKTIPvDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISPNFN
| |...| |. .  ..  ...    .... ...|| |.||| ||..|..|.....|.      .  . . ||.......|  . ....
fhytnwp.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
Rhodanese Rhodanese-like domain 63-169 2.7e-11 36.0 Pfam-A 13-112 (113) alignment 
Range on Protein: 63-169
Range on HMM: 13-112/113.0
RCKLVDCRSFMAFNVAHIRGAVNIHCPPILKRRLLRGSATLSALvsCPESKVILEEADTIIFYDdrtcDWKDLENDSTMKIVAKLLRWeKRKATLFYIKG
.. |.|.||. ...  ||.||||.  . . .|| |.    |.    ..||.  |.. .|...|.      ..  .  .   .|..|.      . ....|
kvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaee..leesgkkldkdktvvvyc....rsgnrsggaaalllalilke.lgyknvyvLdG

GFERFSA
||| ..|
Gfeawka
0050432 (Phosphotyrosine protein) phosphatases II 285-351 3.7e-11 38.4 In-house 209-284 (308) alignment 
Range on Protein: 285-351
Range on HMM: 209-284/308.0
DIGVW--FEEAAGFIDSVKAS--GGRVLVHCQAGISRSATICLAYLI-----SRLNFRLDEAYEYVKKRRSVISPN
| ||   .|.   |.. |. |  || ..||| ||..|..|.....|.        .. . ||. .....|    ..
dhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 285-348 8.7e-11 37.2 In-house 177-256 (284) alignment 
Range on Protein: 285-348
Range on HMM: 177-256/284.0
DIGVW--FEEAAGFIDSVKAS------GGRVLVHCQAGISRSATICLAYLISRL--------NFRLDEAYEYVKKRRSVI
| ||   .|    |.. |. .      || ..||| ||..|..|.....|. ..        .. . ||. .....|   
dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
0048567 (Phosphotyrosine protein) phosphatases II 289-348 6.2e-09 30.4 In-house 59-123 (157) alignment 
Range on Protein: 289-348
Range on HMM: 59-123/157.0
WFEEAAGFIDSVKASGGRVLVHCQAGI---SRSATICLAYLISRLNFRLDEAYEYVKKRR--SVI
..  .  |.....  |... ||| ||    .|.||.. .||| .|.|  .||.....  |  ||.
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_CDC14_pd Subfamily CDC14 246-355 1.4e-08 29.0 In-house 206-316 (328) alignment 
Range on Protein: 246-355
Range on HMM: 206-316/328.0
DVLKRLGISAIVNVSRNIPNtfEDSFTYKTIPVDDTYNADIGVWFEEAA-GFIDSVKASGGRVLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKR
.  .. .....| . ... .  . .|| . .   | . .| ..  ..    |.. .. . | . |||.||. |  |.  .||. . .|   ||  ...  
eyfrknnvttvvrLnkklYd..akkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlric

R--SVISPNFNFM
|  |||.|  .|.
rPGsvigpqqkfl
PTPc_DSPc_SM00012 299-333 1.3e-07 27.1 In-house 28-68 (105) alignment 
Range on Protein: 299-333
Range on HMM: 28-68/105.0
SVKAS------GGRVLVHCQAGISRSATICLAYLISRLNFR
.|| .      .. |.|||.||..|..|....... . . .
avkknknksesskpvvVhCsaGvgRtgtfvaldillqqlek
subfamily_Laforin_pd Subfamily Laforin 268-347 2.9e-06 20.3 In-house 74-153 (183) alignment 
Range on Protein: 268-347
Range on HMM: 74-153/183.0
EDSFTYKTIPVDDTYNADIGVWFEEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKRRSV
|. ..|  .|..|         . .|  .. ..   | .| |||.||. ||..|   .|   |.. |     ..  .| |
eeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv
subfamily_PTPDC1_pd Subfamily PTPDC1 303-346 5.2e-06 21.0 In-house 113-156 (182) alignment 
Range on Protein: 303-346
Range on HMM: 113-156/182.0
SGGRVLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKRRS
. |.| ||| ||  |   .  .||.   ..  ..| . |...|.
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_DSP11_pd Subfamily DSP11 291-346 6.4e-06 20.2 In-house 103-158 (178) alignment 
Range on Protein: 291-346
Range on HMM: 103-158/178.0
EEAAGFIDSVKASGGRVLVHCQAGISRSATICLAYLISRLNFRLDEAYEYVKKRRS
|.   |... | ..  . |||  |. |.  .   |||.. ... ..| |  .. | 
eavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG