Gene PTPDC1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP017_AA protein Get Run
NvecP017_AA_17-180 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPDC1_pd Subfamily PTPDC1 17-187 8.5e-88 287.6 In-house 12-182 (182) alignment 
Range on Protein: 17-187
Range on HMM: 12-182/182.0
EIFAIWITKDILATARPSSEVIKSHCVLEQFKDLGIKSIINLQHPGEHASCGYGLQDSGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFA
 ....|.|.||||.||||.|.|.....|..||. |||..||||..|||||||.||..||||||.||.|. .|..|||||.||||.|||.|||.|||..||
GlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafa

LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLSHLWVIF
|||||.|||||||||||||||.||..|..|||||.||.|.|..|||..|||.|.|.||.|..||..|....
lqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfliplrkvy
0046846 (Phosphotyrosine protein) phosphatases II 18-180 1.2e-36 121.4 In-house 10-172 (176) alignment 
Range on Protein: 18-180
Range on HMM: 10-172/176.0
IFAIWITKDILATARPSSEVIK----SHCVLEQFKDLGIKSIINLQHPGEHASCGyglqdsgFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVM
 .  .|. ......||              ||..|.|||. ..||. . |.....       . .... .....| .....| |.|| .|| .|.... .
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk.......cpnywpeleklgiqylhlpwpDhgvpdlelllellefi

SFALQEG-KTAVHCHAGLGRTGVLICCYFIYS-DRLTAEEAIHLMRKNRP-KAVQTRGQIECVKDFYKFL
  ||.|| ...|||.||.||||.|...| ...   |..|||..|.|. || .||||..|.. ...|...|
realkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
PTEN_1 42-181 2.3e-35 117.2 In-house 58-193 (196) alignment 
Range on Protein: 42-181
Range on HMM: 58-193/196.0
CVLEQFKDLGIKSIINLQHPGEHascgyglqdSGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQ----EGKTAVHCHAGLGRTGVLI
. |...|  || ...|| .  |.         ||.|||.| |..  . ...|...|.|. ||....|..|..  .|.    ... .|||.|||||.|...
adldnlkedgitlvvnlseeeel.........sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

CCYFIYSDRLTAEEAIHLMRKNR-PKAVQTRGQIECVKDFYKFLS
..| .|. .|||.||. |.|. | | |.... | .... |...|.
aayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0038934 (Phosphotyrosine protein) phosphatases II 22-181 3.6e-35 116.8 In-house 15-177 (194) alignment 
Range on Protein: 22-181
Range on HMM: 15-177/194.0
WITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQH-PGEHASCGYGLQDSGFSYDPEAFMQVEIFFYNFGWNDYGV----RSLESILDMVKVMSFA
.||....|...|.|. . ..  .|... ......... .  ...  . . |  ... |||| |... | .... . |.|.      | ..||.|...  .
iitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne

LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLS
 ..|. ||||.|||||||.|...| ||. ...|||||.|.|  ||.|.......| .  .||.| 
dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
0043147 (Phosphotyrosine protein) phosphatases II 21-180 3.4e-33 110.2 In-house 16-160 (172) alignment 
Range on Protein: 21-180
Range on HMM: 16-160/172.0
IWITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPgehascgyglqdsgfSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSF---AL
 .|.....||  | .. . ..  ....|.|||. |.||                   |||| ...  | .. ..| |.|| .|| .|.... .       
yyipdrfiatqgplrntladf..wrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidellals

QEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
..|...|||.||.||||.|...| ..  .|..|||..|.|. ||.|||. .|. ....| |.|
pggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0044763 (Phosphotyrosine protein) phosphatases II 18-180 9.9e-33 108.6 In-house 21-170 (178) alignment 
Range on Protein: 18-180
Range on HMM: 21-170/178.0
IFAIWITKDILATARPSseviksHCVLEQFKDLGIKSIINLQHPGEHASCGyglqdsgfsYDPEAFMQVEIFFYNFGWNDYGVRS-LESILDMVKVMSFA
| | .|. ...... |.       . ||..|.|||..|.|| .. |.  ..         .||..... .| ...... |.|| . || .|..|. .  |
inaseilpglylgslpp......addlellkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdllehflefvefieea

--LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPkAVQTRGQIECVKDFYKFL
   ..|...|||.||.||.|.|...| ... .|..||||.|.|. || .|...||.. ...|...|
ldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
0041856 (Phosphotyrosine protein) phosphatases II 19-180 2e-31 104.4 In-house 18-170 (182) alignment 
Range on Protein: 19-180
Range on HMM: 18-170/182.0
FAIWITKDILATARPSSEVIKS--------HCVLEQFKDLGIKSIINLQhpgehascgyglqdsGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMV
.  .|.  ... ..|... |           . |...|.|||..|.||                .. |.|| ...  | .....| |.|| .|...||..
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...............eelywpellerlgiqylylpwpDhgvpdldelldfi

KVMSFalQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
. .    ..|...|||.||.||||.|...|.... ....|||..|.|. ||..|.|  |.  . ... .|
eevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel
0036282 (Phosphotyrosine protein) phosphatases II 22-181 7.6e-31 102.5 In-house 14-170 (174) alignment 
Range on Protein: 22-181
Range on HMM: 14-170/174.0
WITKDILATARPSSevikshcVLEQFKDLGIKSIINLQHPGEHASCG------YglqdsgfsyDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSF
.||. ..|.. | .        .|..|.|||.....| .. |  ...                ..| . .  | .. ..| |.|| .|. .|..|| .  
yitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpe.........lredlerlgiqylylpwpDhgvpdlsillefvkfvee

ALQE---GKTAVHCHAGLGRTGVLICCYFIYSDRL-TAEEAIHLMRKNR---PKAVQTRGQIECVKDFYKFLS
||.|   |...|||.||.||||.|...| ..   | ....|..|.|. |   |..||| .|.. . .| |.||
alsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
0048076 (Phosphotyrosine protein) phosphatases II 43-180 9.6e-30 98.5 In-house 21-142 (145) alignment 
Range on Protein: 43-180
Range on HMM: 21-142/145.0
VLEQFKDLGIKSIINLqhpgehascgyglqdsgfSYDPEAFMQVEIFFYNFGWNDYGVRSL-ESILDMVKVMSFALQEG-KTAVHCHAGLGRTGVLICCY
 ||..|||||. ..||                  ....| . .  | .....| |.|| .| | .|.... .  ||.|| ...|||.||.||||.|...|
dlellkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

FIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
 ... ....|||..|.|. ||.||.. ||.. ...|.. |
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0049260 (Phosphotyrosine protein) phosphatases II 43-180 6.8e-29 95.9 In-house 25-149 (152) alignment 
Range on Protein: 43-180
Range on HMM: 25-149/152.0
VLEQFKDLGIKSIINLQHPGEHAS--CGYGLqdsgfsydpeafmqveiFFYNFGWNDYGVRSLESILDMVKVMS---FALQEGKTAVHCHAGLGRTGVLI
.....|.|||. |..|  . | .   | ..                   .... | |.|| .|. .|...  .       ..|...|||.||.||||.|.
fwrmlkelgittivmltellelgklkceqyi.................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

CCYFIYsDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
..| ..  ....|||. |.|. ||.||.. ||.. ...|.|.|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0048179 (Phosphotyrosine protein) phosphatases II 44-179 1.1e-28 95.1 In-house 22-143 (144) alignment 
Range on Protein: 44-179
Range on HMM: 22-143/144.0
LEQFKDLGIKSIINLQHPGEHASCGYGlqdsgfsydpeafmqvEIFFYNFGWNDYGVRSL-ESILDMVKVMSFALQ-EGKTAVHCHAGLGRTGVLICCYF
||..|.|||. .|||... |.....                   | .....| |.|| .| | .|.... .  ||. .|...|||.||.||||.|...| 
lellkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

IYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKF
..  .|..|||..|.|. || ||...||.. .....|.
mkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0040439 (Phosphotyrosine protein) phosphatases II 18-179 2.4e-28 94.8 In-house 47-244 (249) alignment 
Range on Protein: 18-179
Range on HMM: 47-244/249.0
IFAIWITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEH--ASCGYGLQDSGFS----------------------------YDPEAFMQVE
|   .|.....||  | .| ....  ......|||..|..| .. |.    |     ..|.                             ||.| ..   
idgyyikrrfiatqgPlpetvedf..wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlh

IFFYNFGwnDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFY
| ....   |.||  |.|..||... .  ||    ..|...|||.||.||||..|..| .     .  ....|||..|.|. ||.|||. .|.. . .. 
iqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

KF
..
le
0039614 (Phosphotyrosine protein) phosphatases II 22-178 2.8e-28 94.7 In-house 87-286 (297) alignment 
Range on Protein: 22-178
Range on HMM: 87-286/297.0
WI-----------TKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEHA--SCGYGLQDSGfSYDPeafM---------QVEIF----------
.|           |....||  |..| ....  .. ....|...|..|  . |.    . |  ...|  |..   .            ..          
YinAsyvdgydlltrkfIatqgPlpetvedF..wrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygd...ftvtllkvehldgytvrtlevtnng

-------FYNFGWNDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIEC
       |  .|| |.||  |||..|.... .  ||    ..|...|||.||.||||..|..| .     .  .....||.. .|. ||.|||| .|.. 
esrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrf

VKDFYK
. |. .
lydall
0045098 (Phosphotyrosine protein) phosphatases II 26-179 3.5e-28 94.2 In-house 65-270 (278) alignment 
Range on Protein: 26-179
Range on HMM: 65-270/278.0
DILATARPSSEVIksHCVLEQFKDLGIKSIINLQHPGEHA--SCGYGLQDSG-----------------------------FSYDPEAFMQVEIFFYNF-
  .||. |  . .  .  ......|||..|..| .  | .   |     ..|                             ... .| ... ... ... 
kfIatqgPlpstv..adfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhyl

GWNDYGVRSLE---SILDMVKVMSFAL---------------QEGKTAVHCHAGLGRTGVLICCYFIYSD---RLTAEEAIHLMRKNRPK-AVQTRGQIE
.| |.|| ||.   |.|.... .  ||               ..|...|||.||.||||.|...| ...    .....||.. .|. ||  |||. .|..
pwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyr

CVKDFYKF
 . .|   
flyeflle
0042113 (Phosphotyrosine protein) phosphatases II 22-179 6.6e-28 93.2 In-house 49-241 (245) alignment 
Range on Protein: 22-179
Range on HMM: 49-241/245.0
WITKDILATARPSSEvikshcV----LEQFKDLGIKSIINLQHPGEHASC----------------------------GYGLQDSGFSYDPEAFMQVEIF
.||. ..||. |..|           ......|||..|..|  . |.  .                            .| .     ..... . .  | 
ritpkfiatqgPlpe......tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevih

FYNFGWNDYGVRS-LESILDMVKVMSFALQ---EGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKF
.. ..| |.|| . ||..||... .  ||.   .|...|||.||.||||..|..| .     .  ....|||.. .|. ||.|||| .|.. . .. ..
yhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 21-179 1e-27 92.7 In-house 40-240 (243) alignment 
Range on Protein: 21-179
Range on HMM: 40-240/243.0
IWITKDILATARPSSEVIKS--HCVLEQFKDLGIKSIINLQHPGEHASCGYGLQDS---------------------------GFSYDPEAFMQVEIFFY
|..|. . ||  | .| ...     .. ...|||..|..| .. |.  ...    .                              .|.. . .  | ..
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

NFGWNDYGVRS-LESILDMVKVMS----------FALQEGKTAVHCHAGLGRTGVLICCYFIYSD-RLTAEEAIHLMRKNRPK-AVQTRGQIECVKDFYK
 ..| |.|| .  |..||... .            . ..|...|||.||.||||.||..| ...  ....|||..|.|. ||  ||||..|.. . ....
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

F
.
e
0045450 (Phosphotyrosine protein) phosphatases II 22-178 1.5e-27 92.5 In-house 104-301 (307) alignment 
Range on Protein: 22-178
Range on HMM: 104-301/307.0
WITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEHAS----CGYGLQDSGFSYDP-------------------------EAFMQVEIFFYN
.... ..||  | .| ....  .......|.. |..| .. |...      . . .. . |..                         . ..  ..  . 
dlkrkfIatqgPlpetvedF..wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfh

F-GWNDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFIYSDR--------LTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
. || |.||  |.|..||... .  ||    ..|...|||.||.||||..|..| ... .        ....||..|.|. ||.|||. .|.. . .. .
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0043336 (Phosphotyrosine protein) phosphatases II 18-178 7e-27 90.0 In-house 81-274 (278) alignment 
Range on Protein: 18-178
Range on HMM: 81-274/278.0
IFAIWITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEHASCG--------------------YGLQDSGFS---------YDPEAfmQVEI
.   .......||  |..| .. .   . ...||...|..|  . |. ...                       .....          .|.|   .   
vdgynvprkfiatqgPlpetvedF..wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvt

FFYNFGWNDYGVR-SLESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
 .. .|| |.||  ||...||..|..  ||  ..|...|||.||.||||..|..| .     .  ....|||.. .|. ||.||||  |.. . .. .
hyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0051082 (Phosphotyrosine protein) phosphatases II 20-172 2.1e-25 84.5 In-house 8-144 (151) alignment 
Range on Protein: 20-172
Range on HMM: 8-144/151.0
AIWITKDILATARPSSevikshCVLEQFKDLGIKSIINLQHPGEHAscgyglqdsgfsYDPEAFMQVEIFFYNFGWNDYGVRSL----ESILDMVKVMSF
. ..|  ..... |..       .||..|.||||.|.||  . |..            |.|| . . .| .... . |  . .|    ...|......  
fsyvtgglyrsggpla......dflellkelgiktivnlrseeerg............ycpeylpelgievlhipildwpdpglplsfdavleflellld

aLQEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNRPKAVQTRGQIEC
  ..|...|||.||.||||.|...| ..  ....|||.. .|. || .||.  |. .
.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflf
0040438 (Phosphotyrosine protein) phosphatases II 23-185 3.2e-25 84.5 In-house 84-280 (317) alignment 
Range on Protein: 23-185
Range on HMM: 84-280/317.0
ITKDILATARPSSEviKSHCVLEQFKDLGIKSIINLQHPGEHA----------------------------SCGYGLQDSGFSY-DPEAFMQVEIFFYnF
... ..||  | ..    .  .. ....|...|..| .. |                                |. |    ... . .   .| .| |  
lkrkfIatqgPlpn..tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhy.t

GWNDYGVR-SLESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLSHLWV
|| |.||  |....||... .  ||.  .|...|||.||.||||..|..| .     .  ....|||.. .|. ||.|||| .|.. . |.  ..    .
gWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0051429 (Phosphotyrosine protein) phosphatases II 44-180 1.5e-23 79.3 In-house 38-224 (272) alignment 
Range on Protein: 44-180
Range on HMM: 38-224/272.0
LEQFKDLGIKSIINLQHPGEHASCGYGLQDSGFSYDPEAFMQVEIFF-----------------------------------------YNFGWNDYGVRS
....|.||||.|..| .. |...... .   |. |    ..  . ..                                         .  .| |.|| .
fwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq

--LESILDMVKVmsfalqEGKTAVHCHAGLGRTGVLICCYFIYsDRLT--------------AEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
  | ..|...        .|.  |||.|| .|||...... ..  ...              .|||.. .|. ||.|||| .|.... .... |
eallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 59-178 7.7e-22 73.8 In-house 167-271 (314) alignment 
Range on Protein: 59-178
Range on HMM: 167-271/314.0
QhpgehascgyglqdsGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQEGKTAVHCHAGLGRTGV-LICCYFIYSDRLTAEEAIHLMR
.               .  |||| | .  | .... . |... .|| ........  | ..|...|||.|| ||||. ....| ..  ....|||.. .|
k...............eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvr

KNRPkAVQTRGQIECVKDFYK
. || .   .|.||  .....
lkRp.inpnpgfieqleqyef
0050432 (Phosphotyrosine protein) phosphatases II 89-173 5.1e-21 70.7 In-house 201-291 (308) alignment 
Range on Protein: 89-173
Range on HMM: 201-291/308.0
FFYNFGWNDYGVRS-LESILDMVKVMSFALQEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
 |.  .| |.|| . .|..||... .   |..|...|||.||.||||..|... .     .  .....||.. .|. || .|||  | . .
hfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
0047943 (Phosphotyrosine protein) phosphatases II 88-173 6.1e-21 70.5 In-house 169-264 (273) alignment 
Range on Protein: 88-173
Range on HMM: 169-264/273.0
IFFYNFGWNDYGVR-SLESILDMVKVMSFALQ----EGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
. |. .|| |.||  ||||.|......  ||.    .|...|||.||.||||..|... .     .  .....||..|.|. || .|||  |.. .
thfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 88-177 1.3e-20 69.4 In-house 168-270 (284) alignment 
Range on Protein: 88-177
Range on HMM: 168-270/284.0
IFFYNFGWNDYGVR-SLESILDMVKVMSFALQ----EGKTAVHCHAGLGRTGVLICCYFIYSD--------RLTAEEAIHLMRKNRPKAVQTRGQIECVK
. |. ..| |.||  |.|..|.... .  .|.    .|...|||.||.||||..|... ...         .....||.. .|. || .|||  |.. | 
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

DFY
.. 
eal
0036941 (Phosphotyrosine protein) phosphatases II 90-181 3e-20 68.2 In-house 173-277 (297) alignment 
Range on Protein: 90-181
Range on HMM: 173-277/297.0
FYNFGWNDYGVRS-LESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFI--------YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDF
|. .|| |.|| .  .|.||... .  .|    ..|.. |||.||.||.|..|... .        .  ...  ||.. .|. || |||| .| . . ..
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea

YKFLS
  .| 
llell
0051299 (Phosphotyrosine protein) phosphatases II 86-173 1.8e-19 65.7 In-house 183-278 (288) alignment 
Range on Protein: 86-173
Range on HMM: 183-278/288.0
VEIFFYNFGWNDYGVRS-LESILDMVKVMSFA--LQEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
  . |. ..| |.|| . .|..||... .  |   ..| ..|||.||.||||..|... .     .  .....||.. .|. || .|||  |.. |
tvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
subfamily_CDC14_pd Subfamily CDC14 40-169 2.6e-19 64.2 In-house 201-313 (328) alignment 
Range on Protein: 40-169
Range on HMM: 201-313/328.0
SHCVLEQFKDLGIKSIINLQHPgehascgyglqdsgfSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFAlqEGKTAVHCHAGLGRTGVLICC
 . .|| |.. ...... | .                 || . | .  .  ..  . | .. | . .  .....  |  ||. ||||.||||||| || |
PeklleyfrknnvttvvrLnkk...............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka..eGaiavhCkaGLGrtGtLiac

YFIYSDRLTAEEAIHLMRKNRPKAVQTRGQ
|...  |.||.|||  .|  ||  | .  |
ylmkhyrftaaeaiawlricrPGsvigpqq
subfamily_DSP23_pd Subfamily DSP23 88-180 4.6e-18 60.3 In-house 52-145 (148) alignment 
Range on Protein: 88-180
Range on HMM: 52-145/148.0
IFFYNFGWNDYGVRSLESILDMVKVMSFALQEGK-TAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
. ..... .||   .|| . ..|.|.  | . ..  .|||  | |||| .. ||..   .|.| |||  .|. || .|.|  | . |.|.  |.
ltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi
0048567 (Phosphotyrosine protein) phosphatases II 77-180 5.6e-18 59.7 In-house 27-138 (157) alignment 
Range on Protein: 77-180
Range on HMM: 27-138/157.0
SYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFAL-----QEGKTAVHCHAGL---GRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRG
 |..  |   . ..|.  . |.|  .|  . . ....   |     .... ||||.|||   |||..||.|| |.  ..|.||||...|  ||. |  | 
lynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrd

QIECVKDFYKFL
.   . ...  |
asyllslynltl
DSPc Dual specificity phosphatase, catalytic domain 44-176 5.5e-16 53.6 Pfam-A 11-130 (133) alignment 
Range on Protein: 44-176
Range on HMM: 11-130/133.0
LEQFKDLGIKSIINLQHPGEHAscgyglqdsgFSYDPEAFMQVEIFfYNFGWNDYGVRSLESILDMVKvmSFALQEGKTAVHCHAGLGRTGVLICCYFIY
|.. ..|||. .||...  ...          ... .. . ...|   .  ...  .. ||.. ....  ... ...| .||| ||. |.. ||..| ..
lalleklgitlvinvtkevpnn..........naikkseieylrip.vedetetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmk

SDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDF
...|...||.......|.| ... |..  . ..
tknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 44-176 5.5e-16 53.6 In-house 11-130 (133) alignment 
Range on Protein: 44-176
Range on HMM: 11-130/133.0
LEQFKDLGIKSIINLQHPGEHAscgyglqdsgFSYDPEAFMQVEIFfYNFGWNDYGVRSLESILDMVKvmSFALQEGKTAVHCHAGLGRTGVLICCYFIY
|.. ..|||. .||...  ...          ... .. . ...|   .  ...  .. ||.. ....  ... ...| .||| ||. |.. ||..| ..
lalleklgitlvinvtkevpnn..........naikkseieylrip.vedetetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmk

SDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDF
...|...||.......|.| ... |..  . ..
tknlslneAyefvkerrskispnagflrqLley
subfamily_PTPMT1_pd Subfamily PTPMT1 81-181 2.7e-15 51.2 In-house 67-169 (171) alignment 
Range on Protein: 81-181
Range on HMM: 67-169/171.0
EAFMQVEIFFYNFGWNDYG-VRSLESILDMVKVMSFALQEGKT-AVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
| . .. . ....   |.    .||.... |....   ..||.  |||.|| ||.. |. || .....|. |||.. ..| |..    . | . .. ...
eewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee

FLS
.| 
kll
PTPc_motif_SM00404 44-177 8.9e-15 49.8 In-house 20-138 (140) alignment 
Range on Protein: 44-177
Range on HMM: 20-138/140.0
LEQFKDLGIKSIINLQHPGEHAscgyglqdsgfsYDPEAFMQVEIFfYNFGWNDYGVRSLESILDMVKVMsfALQEGKTAVHCHAGLGRTGVLICCYFIY
... | |||. .||..   .              .  . |  ..|   .   .|  .. |...||... .  . ..||  ||| ||. |.. ||..| ..
pallkklgithvinvteevslt............kensgfqilqip.lddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmr

SDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFY
.. |...||.......||.  .. . .. . ...
yrqlslaeayefvkerRpiispnlnfvrqLieye
PTPc_DSPc_SM00012 90-173 6e-14 47.5 In-house 5-99 (105) alignment 
Range on Protein: 90-173
Range on HMM: 5-99/105.0
FYNFGWNDYGVRS-LESILDMVKVMSFALQE----GKTAVHCHAGLGRTGVLICCYFIYSDRLTA------EEAIHLMRKNRPKAVQTRGQIECV
..  || | || .  .|||.... .    ..    . . |||.|| ||||.... . ....  .       .. .. .|| ||..|||  |   .
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_PTEN_pd Subfamily PTEN 22-176 9.9e-13 43.5 In-house 24-175 (184) alignment 
Range on Protein: 22-176
Range on HMM: 24-175/184.0
WITKDILATARPSsEVIkSHCVLEQFKDlgIKSIINLQHPGEHAScgYGLQdSGFSYDPEAFmQVEIFFYnfGWNDYGVRSLESILDMVKVMSFALQEGK
.||. |.| . |. | . ...   . .|  .. ... .| ...    | |. |. .|| . | . ..  |  . .|    .|| . ..|. ..  |.| |
yiteniiamgyPa.ekl.ealyRnsled..vvkflekkhkdhyki..ynlr.serkydskkf.dgrvavy..pfdDhnppplelleeivediekwleedk

T---AVHCHAGLGRTGVLICCYFIYSDRLTAE-EAIHLMRKNR---PKAVQTRGQIECVKDF
.   .|||.|| |||||||..|...|  |. . ||..|  ..|    |.|.   |.  |. .
knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy
subfamily_CDKN3_pd Subfamily CDKN3 83-180 4.2e-12 40.1 In-house 95-195 (202) alignment 
Range on Protein: 83-180
Range on HMM: 95-195/202.0
FMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQEG-KTAVHCHAGLGRTGVLICCYFIY-SDRLTAEEAIHLMRKNR-PKAVQTRGQIECVKDFYKF
. |. .  . .   | .| .  | |.... .  .|... || |||. ||||. ..| | ..| .| .  ..||  .|. .  .|.||  | . ...| . 
yqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdk

L
|
l
Y_phosphatase Protein-tyrosine phosphatase 85-173 4.8e-12 41.2 Pfam-A 134-229 (235) alignment 
Range on Protein: 85-173
Range on HMM: 134-229/235.0
QVEIFFYNfGWNDYGVR-SLESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLICCYFIYSDRLT-----AEEAIHLMRKNRPKAVQTRGQIECV
.|. . |. .|.|.||  | .|.||... .      ..|.. ||| || ||||....  .. .   .       ...  .||.||..||.  | . .
evkqlhyt.nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 85-173 4.8e-12 41.2 In-house 134-229 (235) alignment 
Range on Protein: 85-173
Range on HMM: 134-229/235.0
QVEIFFYNfGWNDYGVR-SLESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLICCYFIYSDRLT-----AEEAIHLMRKNRPKAVQTRGQIECV
.|. . |. .|.|.||  | .|.||... .      ..|.. ||| || ||||....  .. .   .       ...  .||.||..||.  | . .
evkqlhyt.nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
DSPc_SM00195 94-173 6.2e-12 40.7 In-house 167-254 (263) alignment 
Range on Protein: 94-173
Range on HMM: 167-254/263.0
GWNDYGVR-SLESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFIYSDR-----LTAEEAIHLMRKNRPKAVQTRGQIECV
.|.| ||  | .|.|......    .  .| . |||.||.||||....  .|.|       .  .| .  .||.||..|||. |   .
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
PTPc_SM00194 94-173 6.2e-12 40.7 In-house 167-254 (263) alignment 
Range on Protein: 94-173
Range on HMM: 167-254/263.0
GWNDYGVR-SLESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFIYSDR-----LTAEEAIHLMRKNRPKAVQTRGQIECV
.|.| ||  | .|.|......    .  .| . |||.||.||||....  .|.|       .  .| .  .||.||..|||. |   .
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
subfamily_RNGTT_pd Subfamily RNGTT 119-169 1.2e-11 38.6 In-house 113-163 (189) alignment 
Range on Protein: 119-169
Range on HMM: 113-163/189.0
EGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQ
|   .|||. |  ||| ||..| .      .|.|..| .|.||. .     
eevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedy
subfamily_PTPN12_pd Subfamily PTPN12 87-173 1.4e-11 38.8 In-house 173-269 (290) alignment 
Range on Protein: 87-173
Range on HMM: 173-269/290.0
EIFFYNfGWNDYGV-RSLESILDMVKVMSFALQEGK--TAVHCHAGLGRTGVLICCYFIYSDrLTAE---------EAIHLMRKNRPKAVQTRGQIECV
. | |.  | | || .| .|.|.... .    .. .   .||| || ||||..|   ....  | ||         . .  .||.|. .|||. | | |
yqfhYt.aWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrel.lkaekipeeldvfdlvlelrkqraalvqtkeqyelv
subfamily_PTPN13_pd Subfamily PTPN13 87-174 9.1e-11 36.5 In-house 167-263 (273) alignment 
Range on Protein: 87-174
Range on HMM: 167-263/273.0
EIFFYNF-GWNDYGVRS-LESILDMVKVMS-FALQEGKTAVHCHAGLGRTGVLICCYFIYS-----DRLTAEEAIHLMRKNRPKAVQTRGQ-IECVK
|.   ||  | |.|| |  ...| .|. .  .. ..|  .||| ||.||.|.||. . .         .  .| .. .|. |   |||. | | . |
evahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk
subfamily_PRL_pd Subfamily PRL 77-176 1.4e-10 35.4 In-house 45-145 (151) alignment 
Range on Protein: 77-176
Range on HMM: 45-145/151.0
SYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQE---GKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNRPKAVQTRgQIECV
.|| |.. . .|   .. ..| .| . | . . ....  . .|      |||| |||||. ||..  .|  . .. |.|....|..|  |. .. |.. .
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrgainsk.qlkfl

KDF
...
eky
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 88-175 2.5e-10 34.9 In-house 179-274 (318) alignment 
Range on Protein: 88-175
Range on HMM: 179-274/318.0
IFFYNfGWNDYGVR-SLESILDMVKVMSFAL---QEGKTAVHCHAGLGRTGVLICCYfIYSDRLTAEEAI------HLMRKNRPKAVQTRGQIECVKD
 . |   | | ||  |  |.||.|.  | |    ..| ..||| || ||||| |    |  .|. ||. .      . .|..|.  |||. | | . |
qyhyt.sWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd.illerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd
subfamily_DSP12_pd Subfamily DSP12 113-179 5e-10 34.0 In-house 75-142 (155) alignment 
Range on Protein: 113-179
Range on HMM: 75-142/155.0
MSFAL-QEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKF
.. || .||.  |||.||. |   ..  |......|  |.|..|... .|..    | .|  | |.| 
ieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
subfamily_PTPRB_pd Subfamily PTPRB 88-171 1.5e-09 32.3 In-house 181-275 (293) alignment 
Range on Protein: 88-171
Range on HMM: 181-275/293.0
IFFYNF-GWNDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFIY-----SDRLTAEEAIHLMRKNRPKAVQTRGQIE
.  |.|  | |.||  . ...||.|. .  |.    ... . ||| ||.||||..|.   .      .| .     .. .|..|   |||  |  
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYi
subfamily_DSP3_pd Subfamily DSP3 77-161 2.3e-09 31.1 In-house 52-139 (162) alignment 
Range on Protein: 77-161
Range on HMM: 52-139/162.0
SYDPEAFMQVEIFFYNFGWNDYGVRSLESILDM-VKVMSFALQE--GKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRP
  ..| . ..|| .. .  .|     |.   .  .| .  ||..  ||  |||..|. |  .|.  | . . ..|. |||. .||.| 
dtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe
subfamily_DSP11_pd Subfamily DSP11 120-166 3.1e-09 31.0 In-house 117-163 (178) alignment 
Range on Protein: 120-166
Range on HMM: 117-163/178.0
GKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQT
   .|||  |. ||| ||| |.|  . . .|.||. . . |  ... 
kligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 90-173 3.8e-09 31.1 In-house 183-280 (325) alignment 
Range on Protein: 90-173
Range on HMM: 183-280/325.0
FYNFGWNDYGVR----SLESILDMVKVMSFALQE-----GKTAVHCHAGLGRTGVLICCYFIYS-----DRLTAEEAIHLMRKNRPKAVQTRGQIECV
|   .|.| ||.    .| |||..|| .|  ..      .   ||| ||.|||||.|. | .        |.   . .. .||.||. |.|  |   .
fqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyili
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 94-175 4.1e-09 31.0 In-house 187-277 (305) alignment 
Range on Protein: 94-175
Range on HMM: 187-277/305.0
GWNDYGV-RSLESILDMVKVMSFALQEGKT---AVHCHAGLGRTGVLICCYfIYSDRLTAEEAIHL------MRKNRPKAVQTRGQIECVKD
 | | || ..  |.|...| .  . ...|     ||| ||.||||| |.   |  .|| .|| . .      .|..|.|.|||  |   . |
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavd.ialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd
subfamily_PTPRD_pd Subfamily PTPRD 85-169 4.7e-09 30.4 In-house 178-269 (564) alignment 
Range on Protein: 85-169
Range on HMM: 178-269/564.0
QVEIFFYnFGWNDYGVR-SLESILDMVKVMSF--ALQEGKTAVHCHAGLGRTGVLICCYfIYSDRLTAEEA------IHLMRKNRPKAVQTRGQ
.|. | .   | | ||  | .|.||... ..     ..| . ||| || ||||. |    .  .|...|.       ....||.|.  |||. |
eVrqFhF.tsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfivid.amlerikeektvDiyqyvkalrkqRnamVqteeQ
subfamily_VSP_pd Subfamily VSP 76-160 6.6e-09 30.0 In-house 85-170 (212) alignment 
Range on Protein: 76-160
Range on HMM: 85-170/212.0
FSYDPEAFMQVeifFYNFGWNDYGVRSLESILDMVKVMSFALQEGK---TAVHCHAGLGRTGVLICCYFIYSDRL-TAEEAIHLMRKNR
 .||.. | .      .   .|. | .|| .| . | .   |.. .    |.||  | |||| ..|.....|. . ||.|... . . |
raydekyfnnr...vkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerr
subfamily_PTPRA_pd Subfamily PTPRA 90-207 8.8e-09 29.7 In-house 196-315 (330) alignment 
Range on Protein: 90-207
Range on HMM: 196-315/330.0
FYNFGWNDYGVRSL-ESILDMVKV-MSFALQE-GKTAVHCHAGLGRTGVLICCYFIYsDRLTAEE------AIHLMRKNRPKAVQTRGQIECVkdfYKFL
|.  .| | || .    .|...|   .   |. |   ||| || |||| .|    .  .|. ||.      ... .|..||. |||  | | .   || |
fhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavl.ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi...ykvl

SHLWVIfpsSHSEAKQFTLENYLKKQR
 . ..      .| . ..||..|.|  
leyyly...gdteldvsslekhlqkly
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 86-173 1.1e-08 29.5 In-house 175-271 (288) alignment 
Range on Protein: 86-173
Range on HMM: 175-271/288.0
VEIFFYNF-GWNDYGV-RSLESILDMVKVMSFALQE--GKTAVHCHAGLGRTGVLICCYFIY-----SDRLTAEEAIHLMRKNRPKAVQTRGQIECV
.||  |.. .| | || .| . .|.... .  | |.  |.  ||| ||.||||. |    .      .| .   .... .||.|.  |||  | | .
leitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 88-173 1.3e-08 29.2 In-house 156-256 (270) alignment 
Range on Protein: 88-173
Range on HMM: 156-256/270.0
IFFYNfGWNDYGVRSLES-------ILDMVKVMSFALQEG----KTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIE
 |.||  |.| || . |        .| |.. .    .|      . ||| ||.||||.||   ..      . ..   . |. .||.|.. ||.  |.|
Hfwyn.tWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqye

CV
 .
fl
subfamily_DSP1_pd Subfamily DSP1 116-162 1.4e-08 29.0 In-house 92-138 (163) alignment 
Range on Protein: 116-162
Range on HMM: 92-138/163.0
ALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPK
  ..||  .||.||. |   |.  |.. ..|.. ||| ......|. 
kkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 90-171 1.7e-08 29.1 In-house 190-280 (298) alignment 
Range on Protein: 90-171
Range on HMM: 190-280/298.0
FYNFGWNDYGVR-SLESILDMVK-VMSFALQEG--KTAVHCHAGLGRTGVLICCYFIYsDRLTAEE------AIHLMRKNRPKAVQTRGQIE
.  . | | ||    .|.||... |     | |     |.| || ||.|  |  . .  .|. .|.      ... .||.||.||||. |  
lhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvl.ervkkeqvvDvfqvvkvlRkkrpgavqteeqYv
subfamily_LRR-DSP_pd Subfamily LRR-DSP 118-181 1.9e-08 27.7 In-house 196-259 (263) alignment 
Range on Protein: 118-181
Range on HMM: 196-259/263.0
QEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLS
..|   ||| ||. |.  |. .|..  .||. .||. |. |.||.    .| .. .| . | |.
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_PTPRK_pd Subfamily PTPRK 85-175 2.2e-08 28.3 In-house 174-271 (314) alignment 
Range on Protein: 85-175
Range on HMM: 174-271/314.0
QVEIFFYnFGWNDYGVR-SLESILDMVKVMSFA--LQEGKTAVHCHAGLGRTGVLICCYFIySDRLTAEE------AIHLMRKNRPKAVQTRGQIECVKD
.|  | .  || |..|  | ...|..|. .      ..|.. ||| || ||||. | .  .  | .  |.      |.. .|....  |.|  |   . |
evrqfqf.lgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv.ldmieregvvdvfnavktlrsrkvnmveteeqykfiyd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 103-173 2.2e-08 28.6 In-house 201-276 (297) alignment 
Range on Protein: 103-173
Range on HMM: 201-276/297.0
LESILDMVKVMSFALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEE-----AIHLMRKNRPKAVQTRGQIECV
|  ... |.      .||   ||| ||.||||||.    . ..    .|      .. .|..||. |||. | . |
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 86-172 2.4e-08 28.4 In-house 180-274 (319) alignment 
Range on Protein: 86-172
Range on HMM: 180-274/319.0
VEIFFYNfGWNDYGV-RSLESILDMVKVMSFALQE---GKTAVHCHAGLGRTGVLIcCYFIYSDRLTAEEAIHL------MRKNRPKAVQTRGQIEC
|  | |.  | | .| ... |.||..| .  . ..   |   ||| || ||||  |   ..  .|.  |... .      .|  |.  ||.  | . 
vkhfqyt.eWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfi.vldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkf
subfamily_Ptp69D_pd Subfamily Ptp69D 84-160 2.7e-08 28.3 In-house 182-259 (307) alignment 
Range on Protein: 84-160
Range on HMM: 182-259/307.0
MQVEIFFYNfGWNDYGV-RSLESILDMVKVM--SFALQEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNR
 .|  . |. ||.|. | .. ...|.... .     |...   ||| || ||.|....   .  ..| ||. ....   .
rkvvqyhyt.gWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsll.qqlkaedkvdifetvk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 90-174 5.1e-08 26.7 In-house 94-187 (440) alignment 
Range on Protein: 90-174
Range on HMM: 94-187/440.0
FYNFGWNDYGVRSLE-SILDMVKVMSFA---LQEGKTAVHCHAGLGRTGVLICCYFIY-----SDRLTAEEAIHLMRKNRPKAVQTRGQIECVK
..  || | ||  .   .| |.. .. .     .|   ||| || |||||.|.   |      ||..     |  ||.|||. |||  |   |.
yhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh
subfamily_DSP19_pd Subfamily DSP19 116-173 5.7e-08 27.2 In-house 85-143 (152) alignment 
Range on Protein: 116-173
Range on HMM: 85-143/152.0
ALQE-GKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
|... |   |||.||  |.  ..  |.. . .|. |||..|.|. || .    | |. .
arskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqL
subfamily_Tensin_pd Subfamily Tensin 77-152 1.3e-07 24.3 In-house 62-137 (189) alignment 
Range on Protein: 77-152
Range on HMM: 62-137/189.0
SYDPEAFMQvEifFYNFGWNDYGVRSLESILDMVKVMSFALQEGKT---AVHCHAGLGRTGVLICCYFIYSDRLTAEEA
.|| . . . .    .||| |    ||| .  ..| .   |..      .|||. | ||.||.. .|  ||.  ....|
rydisklnk.k..vldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsaymkyskisasada
subfamily_PTPN6_pd Subfamily PTPN6 60-173 1.5e-07 25.7 In-house 160-289 (306) alignment 
Range on Protein: 60-173
Range on HMM: 160-289/306.0
HPGEHASCGYGLQDSGFSYDPEAFMQVEIFFYNF-GWNDYGVRSLES-ILDM---VKVMSFAL---QEGKTAVHCHAGLGRTGVLICCYFIYS----D--
.  |..   | | .   |   ..  . |.| |.|  | | ||..  . .||.   |.  .  |   ..| . ||| ||.|||| .|    . .       
nvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgl

--RLTAEEAIHLMRKNRPKAVQTRGQIECV
   .  .......|. |   |||  |   |
dadidiqklvksvreqrsglvqteqqykfv
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 100-178 2.3e-07 24.3 In-house 72-150 (154) alignment 
Range on Protein: 100-178
Range on HMM: 72-150/154.0
VRSLESILDMVKVMSFALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
...|.  .....    .....|  ||...|. |.  |.  |.. . ...  .|. |... |..    .| .. .. | |
iekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 91-172 2.8e-07 25.0 In-house 143-233 (250) alignment 
Range on Protein: 91-172
Range on HMM: 143-233/250.0
YNFGWNDYGVR-SLESILDMVKVMSFALQE---GKTAVHCHAGLGRTGVLICCYFIYsDRLTAE------EAIHLMRKNRPKAVQTRGQIEC
  . | | ||    ...|...| .    |.   .   |.| || ||.|  |  . .  .||  |      . |. .||.||.||... |   
hfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl.erlkkekvvdvfkvikvlrkdrphavesleqyvf
subfamily_DSP14_pd Subfamily DSP14 111-163 2.8e-07 24.6 In-house 75-127 (157) alignment 
Range on Protein: 111-163
Range on HMM: 75-127/157.0
KVMSFALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKA
|. .   ..||| ||| ||  |   |   | .   .|. .|| .|... ||  
kieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpii
subfamily_PTPN3_pd Subfamily PTPN3 94-173 3.4e-07 24.5 In-house 180-267 (280) alignment 
Range on Protein: 94-173
Range on HMM: 180-267/280.0
GWNDYGVRS-LESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLIC-----CYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
 | | || .  ...|..|. .  .   .|  . ||| ||.|||||||      .    .. .   . .. ||  |   ||| .| . |
aWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 91-173 3.5e-07 24.4 In-house 179-269 (315) alignment 
Range on Protein: 91-173
Range on HMM: 179-269/315.0
YNFGWNDYGVR-SLESILDMVKVMS--FALQEGKTAVHCHAGLGRTGVLICCYFIYS-----DRLTAEEAIHLMRKNRPKAVQTRGQIECV
   .| | ||   . |.| ..| .      .|    ||| || |||||.|    . .     . .   . .. .|..||. |||. .   .
qftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafi
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 83-153 4.1e-07 21.3 Pfam-A 96-168 (168) alignment 
Range on Protein: 83-153
Range on HMM: 96-168/168.0
FMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQE-GKTAVHCHAGLGRTGVLICCYFIY-SDRLTAEEAI
. |. |  .    .| |   . | |.... .. .|..  || .||. ||||. .. .| ..| || .. |.||
yqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 83-153 4.1e-07 21.3 In-house 96-168 (168) alignment 
Range on Protein: 83-153
Range on HMM: 96-168/168.0
FMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQE-GKTAVHCHAGLGRTGVLICCYFIY-SDRLTAEEAI
. |. |  .    .| |   . | |.... .. .|..  || .||. ||||. .. .| ..| || .. |.||
yqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 92-174 4.7e-07 24.0 In-house 169-259 (283) alignment 
Range on Protein: 92-174
Range on HMM: 169-259/283.0
NFGWNDYGVRS-LESILDMVKVMSFALQE--GKTAVHCHAGLGRTGVLICCYFIYSDRLTA-----EEAIHLMRKNRPKAVQTRGQIECVK
  .| .||  . ..|.. . ||.|   ..  |   ||| .| |||.|.|       | ||       . .. ||..|. ||||..|   | 
vidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 69-171 7e-07 24.0 In-house 132-245 (284) alignment 
Range on Protein: 69-171
Range on HMM: 132-245/284.0
YGLQDSGFSYDPEAFMQVEIFFYNF-GWNDYGVRSLES-ILDMVKVMSFA---LQ-EGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHL------M
| ..|   | | .   . .|  . | || |.||    | .. .|| ..      . . .  ||| || ||||| |.   .  ||.  |. . .      .
yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll.drmkeekqvdvynfvrdl

RKNRPKAVQTRGQIE
|..|.. ||   |  
rqqrntlvqdlvqyk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 69-171 7.7e-07 23.7 In-house 168-281 (319) alignment 
Range on Protein: 69-171
Range on HMM: 168-281/319.0
YGLQDSGFSYDPEAFMQVEIFFYNF-GWNDYGVRSLES-ILDMVKVMSFA---LQ-EGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAI------HLM
| ..|   | | .   . .|  . | || |.||    | .. .|| ..      . . .  ||| || ||||| |    .  ||.  |. .      . .
yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll.drmkeekqvdvynfvrdl

RKNRPKAVQTRGQIE
|..|.. ||   |  
rqqrntlvqdlvqyk
subfamily_DSP15_pd Subfamily DSP15 117-177 8.1e-07 23.2 In-house 76-136 (151) alignment 
Range on Protein: 117-177
Range on HMM: 76-136/151.0
LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFY
|.|..  ||| ||. |   |.  |..    |  ..|.. ....|  |    |  . .|.. 
lkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 93-167 1.1e-06 22.6 In-house 194-273 (305) alignment 
Range on Protein: 93-167
Range on HMM: 194-273/305.0
FGWNDYGVRSLE-SILDMVKVMsfALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLtAEEAI-------HLMRKNRPKAVQTR
  | | || . . .||....        | ..||| ||.|||| ..   .|  . | | . |         .|..| ...|| 
idwpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvmleyildqll.agqiiedtdkilqkireqrnnsiqtd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 95-176 1.1e-06 22.9 In-house 185-274 (315) alignment 
Range on Protein: 95-176
Range on HMM: 185-274/315.0
WNDYGVR-SLESILDMVK-VMSFAL-QEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIH------LMRKNRPKAVQTRGQIECVKDF
| | ||  .  ....... |. .   . |   |||.|| |||| .|.   .  |.. ||.||        .|.|| |.||.  | . . | 
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl.dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 88-173 1.8e-06 22.2 In-house 165-260 (274) alignment 
Range on Protein: 88-173
Range on HMM: 165-260/274.0
IFFYNfGWNDYGV-RSLESILDMVKVMSFALQEGK-----TAVHCHAGLGRTGVLICCYfIYSDRLTAEEAIHLM------RKNRPKAVQTRGQIECV
 ..|   | |  . .. ...||.|. .. . .| .     . ||| ||.||||. |    |   .| .|. . ..      | .|   |||. | | .
hywyt.dWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais.iavrqlreeivvdvlkivcnlrldrGGmvqtseqyeli
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 93-172 3.9e-06 20.2 In-house 180-267 (515) alignment 
Range on Protein: 93-172
Range on HMM: 180-267/515.0
FGWNDYGVRS-LESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFIYSDRLTAE-----EAIHLMRKNRPKAVQTRGQIEC
 .| | ||     |.| ..| .    .  .    .|| || |||||.|    . ..  |..     . .. .|..||. |||. |   
teWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 89-171 4e-06 20.8 In-house 184-271 (301) alignment 
Range on Protein: 89-171
Range on HMM: 184-271/301.0
FFYNF-GWNDYGVRslESILDMVKVMSFALQEGK-TAVHCHAGLGRTGVLICCYFIYSD-----RLTAEEAIHLMRKNRPKAVQTRGQIE
  |..  | |.||   .|  .. ..| .. .  |   ||| ||.||.  .|   .. ..     ..   ||.. .|..| ..|||. |. 
thyqysewtdrgvP..kshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_PTPN14_pd Subfamily PTPN14 122-173 4.7e-06 20.8 In-house 232-288 (300) alignment 
Range on Protein: 122-173
Range on HMM: 232-288/300.0
TAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
  ||| || |||||||   ..       ...  ..... .|. |   ||| .| . |
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv
subfamily_DSP10_pd Subfamily DSP10 121-162 6e-06 20.2 In-house 94-135 (159) alignment 
Range on Protein: 121-162
Range on HMM: 94-135/159.0
KTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPK
.  |||.||. |   ..  | ..  .|. ..| ......|| 
rvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 94-173 6.5e-06 20.5 In-house 179-268 (281) alignment 
Range on Protein: 94-173
Range on HMM: 179-268/281.0
GWNDYGVR-SLESILDMVKVM-SFALQEG--KTAVHCHAGLGRTGVLICCYFIYS------DRLTAEEAIHLMRKNRPKAVQTRGQIECV
 | | ||  . . .|.  | . ..  ..      .|| || ||||. |    . .       .|  .. .. .||.|   |||  | | |
aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 120-176 7.3e-06 20.0 In-house 229-290 (297) alignment 
Range on Protein: 120-176
Range on HMM: 229-290/297.0
GKTAVHCHAGLGRTGVLICCYFIYSD----RLT-AEEAIHLMRKNRPKAVQTRGQIECVKDF
  . ||| ||.||.||.. .  | .     |.  .   .. .|..|.. |||  | | . |.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Laforin_pd Subfamily Laforin 108-178 7.7e-06 18.9 In-house 98-170 (183) alignment 
Range on Protein: 108-178
Range on HMM: 98-170/183.0
DMVKVMSFALQEGK-TAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKA-VQTRGQIECVKDFYK
. | ..   |..|.   ||| ||.||.  ..| .. |    .     . .  .|| . .. .  | . |||..
qavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdfiq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 122-159 7.8e-06 19.8 In-house 265-302 (350) alignment 
Range on Protein: 122-159
Range on HMM: 265-302/350.0
TAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKN
  ||| || ||||.|.   .. || .  |.  . .|| 
ilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkl