Gene MTMR10 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP027_AA protein Get Run
NvecP027_AA_171-561 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR10_pd Subfamily MTMR10 166-559 4.9e-151 494.8 In-house 2-379 (380) alignment 
Range on Protein: 166-559
Range on HMM: 2-379/380.0
GVIPTFRTLPDWLNELSRLNVDDTWRVALVNEKFHTCPTLPQRFVCLASLTDSDVNRMSLHYEESRFPLWCWSHPKTRVPIMLSASGRPESIFLEKEETS
......|.....|.| .. .|.|...|.|.||.|....||||.||...||.||||.|.| ||.|||||||.|||.|......|||....||...||||..
askeawrselerleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekm

LFRALSSIPANpehkDVKVVDLSKICPSIQQLSQSYLRVRELCVLDTTKNFWSIDPHWLSSLDNSRWLASVRTSISTAVDVCKAVCEEGRPVIVKEASGR
|... ...|||    |||.||||...||||.....||..|||||.||...|...|..|||||...||||.||...|||.|..|.|.|..|.||..|..||
lelvrkchpan....dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegr

DLVLVVCSLAQLMLDQYYRNIRGFQTLIQKMWVLGGHPFMKRCGHIKPNEKSDAdkqeneesPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHAC
||..||.||||||||..||.|.|||.||||.||..||||..|.|||||.|||..        ||||.|||||.||..||||||||.||.|. ..||.|..
DlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpsekses........pvfllFldcvdqlleqfpseFeFtetfLialwdsshsg

LFDEFLFDCEHQRQKYINSEFggaPMASLWDFLAEQLSDsQNTAAFINPLNEFKRLSSKNPMNGDNEIEEIYSRVNPTAPAMKFWSGCYLRWLP
.|..|||..|.||.|...|     |..    .| |. .. ..   . ..|.  .. | ..  .. . ..  . |     | .. |. |||||.|
ifltflfnseeqrlkavvsss...plliakselkendll.kdeldyrqglyaeiiksirrlaaaksylrseiirPllqipdiqlWdeCYlRWvP
0040695 (Phosphotyrosine protein) phosphatases II 170-559 7.5e-82 269.0 In-house 6-387 (388) alignment 
Range on Protein: 170-559
Range on HMM: 6-387/388.0
TFRTLPDWLNELSRLNVD-DTWRVALVNEKFHTCPTLPQRFVCLASLTDSDVNRMSLHYEESRFPLWCWSHPKTRVPIMLSASGRPESI-----FLEKEE
 . .| |.|.||.||... |.||.  |||..  ||..|...|. .|..|....|.. ...  |.| ....||..   .. |.   .  .       ||  
egwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledekll

TSLFRALSsipanpEHKDVKVVDLSK----------------------------ICPSIQQLSQSYLRVRELCvlDTTKNFWsidpHWLSSLDNSRWLAS
......|.      ... . .||| .                             .|.|... .|. .....|  . ....     ..||.|..|.||  
eailkllp......nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac..lnvpdsl....nllslleesgwldl

VRTSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQTLIQKMWVLGGHPFMKRCGHIKPNEksdadkQENEESPVFLHFLD
... ...|| ..| .  .. .|.| . .|.|.. ...|||||.|| ||| ..|||.||.| |.. ||.|..|.||   .       . .|.||||| |||
iklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghlesei......dskefsPvFllFLd

CVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQKYINsefgGAPMASLWDFLAEQLSDsqntaaFINPLNEFKRlssknpmngdneieE
||.||. |||..|||.|..|| ..|....|.|..|||..|..| ..         . |||..|  . |.      |.||| .                 .
cvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsv....sertlslwsyllsrkse......flnplYdpss..............l

IYSRVNPTAPAMKFWSGCYLRWLP
.. ....  . ...|...||||||
evllpslsvldlllWleyylrwlp
Myotub-related Myotubularin-like phosphatase domain 282-480 7.4e-63 205.4 Pfam-A 165-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 282-480 7.4e-63 205.4 In-house 165-352 (353) alignment
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 293-557 8.8e-55 178.5 In-house 166-402 (404) alignment 
Range on Protein: 293-557
Range on HMM: 166-402/404.0
SIQQLSQSYLRVRELCvldttKNFWSIDPHWLSSLDNSRWLASVRTSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQTL
 |..| .|. ......     ..  . . .||| |..||||  ... .... .. . . .|. .|.|.   | |    ..||.||.|| |||.|.||. |
nihelreslkklkkav.....nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivl

IQKMWVLGGHPFMKRCGHikpneksDADKQENEESPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQ-KYINSEfggapM
|.| |.  || |..|.|.          |...|.||.|| |.||||||. |||..|||.| .|. .||.. .| | .||.|.|..|| . ...|     .
iekewlsfGhkfaqRigq.......ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlake.....t

ASLWDFLAEQLsdsqntAAFINPLNEFKRL-----SSKNPMNGDNeieeiysrvnpTAPAMKFWSGCYLRW
 |||  | ..         ..|||   ..       ... .. ..               .|.||  ||||
vslWalleank......seylnplyilekkeqkenitssessssa...........dikliklWseyylrw
subfamily_MTMR9_pd Subfamily MTMR9 292-557 3.5e-54 176.4 In-house 160-392 (393) alignment 
Range on Protein: 292-557
Range on HMM: 160-392/393.0
PSIQQLSQSYLRVRELCVldttkNFWSIDPHWLSSLDNSRWLASVRTSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQT
 |.... .|. .. | |      .      ..|| |..| || .|. ....|. | ... ||| ||.|....| |  |.| |||||.|| ..|..|||. 
esvasiqdslaklleacs.....daglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfea

LIQKMWVLGGHPFMKRCGHIKPNEksdadKQENEESPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQKY-INSEfggap
||.. |. .|||| .|. ..  .|     .......|||| |||||||...||| .|||.|..|  .    ... |  || |.|..|..  ....     
liereWiqaGHPFasRaskvaake.....tkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkk.....

MASLWDFLaeqlSDSQNTAAFINPLNEfkrlssKNPmngdneiEEIYSRVNPtaPAMKFWSGCYLRW
  |||...       ...  |.||| |      .|        | | . |.|  .....||. ||||
tvslwsyv....nrpeklkqflnplye......ana.......eviwpsvap..qslelWselylrw
subfamily_MTMR1_pd Subfamily MTMR1 292-503 4.9e-54 176.1 In-house 156-351 (389) alignment 
Range on Protein: 292-503
Range on HMM: 156-351/389.0
PSIQQLSQSYLRVRELCVLDTTknfwsiDPHWLSSLDNSRWLASVRTSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQT
..|. . .|. ...||.. ..       | .|||.|....||  ... ...|| . ..| .|   |.|    | |    . |||.|.|| ||| |.||..
hnihvvReslkklkelvlpnvd......dkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfev

LIQKMWVLGGHPFMKRCGHikpnekSDADKQENEESPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQKYINSefggAPM
||.| |.  ||.| .| ||      .|......|.||||| |.|||.||  |||. ||| |..|. .|| ...|||  |||..|..|.|   .       
liekeWlsfGHkfkeRlgh......gdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkekvk....ekt

ASLWDFLAEQLS
 ||| .. .. .
vslwsyvnsske
subfamily_MTMR3_pd Subfamily MTMR3 292-507 3.7e-50 164.0 In-house 213-412 (442) alignment 
Range on Protein: 292-507
Range on HMM: 213-412/442.0
PSIQQLSQSYLRVRELCVldTTKNfwsiDPHWLSSLDNSRWLASVRTSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQT
. |  . .|.  .|.|.   ....    ...|||.|.. .||  . . . .|| |..|| .|||||.|  . | |    . .||.|.||.||| ..||. 
anihavrksfnslralls..qspd....esnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkv

LIQKMWVLGGHPFMKRCGHikpneKSDADkQENEESPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQKyinsEFGGAPM
|... |.  || |. ||||     ... | ..|| .|||| .||.|.||  |||. |||.|..|. ..   ..|||  ||...|..|..    |   . .
lvereWldfGhkfadrcgh.....genvd.danercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekeree....ekvkert

ASLWDFLAEQLSDSQN
 |.|..| ..  . .|
lsvWsllrakekeyrn
subfamily_MTMR6_pd Subfamily MTMR6 320-519 3.4e-49 160.2 In-house 189-370 (397) alignment 
Range on Protein: 320-519
Range on HMM: 189-370/397.0
DPHWLSSLDNSRWLASVRTSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQTLIQKMWVLGGHPFMKRCGHIkpneksda
  ..||.|..| ||  ... . ... ..||| |||  |.|  . | |    |||||.|.||.||| |.||. ||.| |.  || | .|||..        
vseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll........

DKQENEESPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQKYINSEfggaPMASLWDFLAEQLSDsqntaaFINPLNEFK
|... | ||.|. ||.||.||..|||  |||.|..|| . | ...| | .|| .||..|..   .|       ||| .|.|. .|      ..||| . .
dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklke....rtkslwayllerkdd......ylnplykae
subfamily_MTMR5_pd Subfamily MTMR5 292-515 5.1e-41 133.0 In-house 236-454 (483) alignment 
Range on Protein: 292-515
Range on HMM: 236-454/483.0
PSIQQLSQSYLRVRELCVLDTTKNFWSIDPhWLSSLDNSRWLASVRTSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQT
. |.|. .|. ...  |. .|. .  .    .|.|...| ||  ... .  .. | . .  .|  |.|    |.|.   | |||||.|| ||| . ||..
veirqvkasfkkllraClpstaveeaesqs.FlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkv

LIQKMWVLGGHPFMKRCGHIKPNEKSdadkqenEESPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQKY--INSEFGGA
|..| |.  || | ||. ... ...|         .|||| |||||.|. .||| .|||.. ||  .     .. |  ||.|.|..| .   . .| . .
LveKEWLafGHrFtkrsnqtlsaqss.......gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaek

PMA----SLWDFLAEQlsdSQNTAAFINPL
..     |.||.. .|   ......| | |
rakkagksvwdyidrq...hkrspifynfl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 318-480 1e-33 108.7 In-house 198-351 (405) alignment 
Range on Protein: 318-480
Range on HMM: 198-351/405.0
SIDPHWLSSLDNSRWLASVRtSISTAVDVCKAVCEEGRPVIVKEASGRDLVLVVCSLAQLMLDQYYRNIRGFQTLIQKMWVLGGHPFMKRCGHIKPNEks
| | ..   .... |.. .. ||  |  .   .   |  ..|. . | |    . ||.|..|| ||| | ||| ||.| |.  || |  | ||.  ||  
stdmrfwgyieetgwishik.sileaatfsaelilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgne..

dadkqeNEESPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRQK
      .| ||.| .||||..||..|||  |||. . || . | .|.| .  || .||..| .
......eerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvq
subfamily_pats1_pd Subfamily pats1 318-424 1.8e-18 58.3 In-house 365-474 (691) alignment 
Range on Protein: 318-424
Range on HMM: 365-474/691.0
SIDPHWlSSLDNSRWLASVRTSISTAVDVCKAVcEEGRPVIVKEAS-GRD--LVL-VVCSLAQLMLDQYYRNIRGFQTLIQKMWVLGGHPFMKRCGHIKP
. |  | ... .| |. ||.  ...||.|.. . .||. |..|... . .  | |  . ||||...| .|| . ||. ||.| |.  |.|| |.. | . 
gsddew.keieeskwvdsvkllleaavkvsnll.deGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskinyhkes

NE-KSDADKQEN
.. . .  ..||
ddlnnnngnken
Myotub-related Myotubularin-like phosphatase domain 147-287 5.5e-18 57.8 Pfam-A 3-140 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 147-287 5.5e-18 57.8 In-house 3-140 (353) alignment
subfamily_MTMR9_pd Subfamily MTMR9 179-256 1.8e-14 45.6 In-house 22-98 (393) alignment 
Range on Protein: 179-256
Range on HMM: 22-98/393.0
NELSRL-NVDDTWRVALVNEKFHTCPTLPQRFVCLASLTDSDVNRMSLHYEESRFPLWCWSHPKTRVPIMlsASGRPES
||...|  . | ||.. ||..|. |.. |. ..  ....| ... .. . |..|||. .. | .|. ...  .|..| .
nefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavll..rssqplc
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 170-249 4.3e-13 41.2 In-house 14-95 (404) alignment 
Range on Protein: 170-249
Range on HMM: 14-95/404.0
TFRTLPDWLNELSRLNVDDT--WRVALVNEKFHTCPTLPQRFVCLASLTDSDVNRMSLHYEESRFPLWCWSHPKTRVPIMLS
 . .. |  .| .||..     ||.. .| ... |.| |. .|   |..|....... . .. |.|  .| |..... |. |
dgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRs
subfamily_pats1_pd Subfamily pats1 427-518 5.4e-13 40.2 In-house 553-634 (691) alignment 
Range on Protein: 427-518
Range on HMM: 553-634/691.0
SPVFLHFLDCVYQLITQFPSEFEFSETYLLGMLDSMHACLFDEFLFDCEHQRqkYINSEFGGapMASLWDFLaeqlsdSQNTAAFINPLNEF
||.|. ||| |.||  .||  ||| | .|| ...  ..  | .||..   ..    .  .      |.| |        || . ||| |   
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrd..serkvlkr..sksiwsfi......nqnksrfinllykh
subfamily_MTMR3_pd Subfamily MTMR3 171-249 9.6e-12 37.4 In-house 23-103 (442) alignment 
Range on Protein: 171-249
Range on HMM: 23-103/442.0
FRTLPDWLNELSRLN--VDDTWRVALVNEKFHTCPTLPQRFVCLASLTDSDVNRMSLHYEESRFPLWCWSHPKTRVPIMLS
 ..  .  .|..||   ....||.. ||..|. |.. |....  .|.||.|... . .   .|.|   | | |..  .. .
svaeeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarc
subfamily_MTMR5_pd Subfamily MTMR5 185-247 1.3e-11 36.0 In-house 26-88 (483) alignment 
Range on Protein: 185-247
Range on HMM: 26-88/483.0
NVDDTWRVALVNEKFHTCPTLPQRFVCLASLTDSDVNRMSLHYEESRFPLWCWSHPKTRVPIM
.  ...|.. ||.|. .| . |  .|   .. |. ..|.. .... |.|. .| |....  ..
skrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLi
subfamily_MTMR1_pd Subfamily MTMR1 182-250 1.6e-10 32.8 In-house 17-87 (389) alignment 
Range on Protein: 182-250
Range on HMM: 17-87/389.0
S--RLNVDDTWRVALVNEKFHTCPTLPQRFVCLASLTDSDVNRMSLHYEESRFPLWCWSHPKTRVPIMLSA
   .|  ...||.. .|.|.. |.| |. .| ... .|.|.....  ....|.|  .| .....  |. ..
erlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilras
3-PAP Myotubularin-associated protein 544-588 4.5e-07 20.2 Pfam-A 83-122 (142) alignment 
Range on Protein: 544-588
Range on HMM: 83-122/142.0
APAMKFWSGCYLRWLPTVHlsIGMGENSSLHMQQMIVMNEVkflT
 . ...|| |||||.| ..  |  |  ...  .......|.    
gldlslWsqcylRwiPeae..ikgggqvqvdlklselleei...a