Gene MTMR9-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR9
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP033_AA protein Get Run
NvecP033_AA_123-507 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR9_pd Subfamily MTMR9 110-504 4.6e-198 650.1 In-house 1-393 (393) alignment 
Range on Protein: 110-504
Range on HMM: 1-393/393.0
PFFYRHVGALSgEDGWDMFSNDLDFAKVCSSTQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCG
|||||.| . . |||...|.....|||..|....||||.|| |..||||||.||||| ...|.||||||.||.|.|||||.|.||.|..||.||..||||
pffyrsvatil.edgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcg

SmSNKRCKEDEKLVNSALGSMKKGMIVDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEACFDQNLSMNAYLSRLESCGWMDQ
| |.|||||||||.|..|...|||.||||||..|..|.||||||.|.|..|.|||......|..... ||..||.||| |..||.. .|||||..||..|
s.sgkrckedekllnlvlkklkkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsq

IQAVLGTACYVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRCTRVGFSSTKYKGQGPVFLLFLDCVWQI
....| .|..||.||...|.||.||...|||||||||||.|.|||||.||||||..|..||||..||||..|...|....||.| .|||||||||||.||
vadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqi

YQQFPCSFEFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDEILEDMLNPMYERNESVLWPSVAPQSLVLWPGLYLKWQ
..|||.||||....||.||||.|.||||||||.||..| ..|||.||.|||||.|..| |...|||.||.|..|.|||||||||.|| .|||.||
lsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyeanaeviwpsvapqslelWselylrwq
0040695 (Phosphotyrosine protein) phosphatases II 122-504 3e-121 398.6 In-house 5-386 (388) alignment 
Range on Protein: 122-504
Range on HMM: 5-386/388.0
EDGWDMFSNDLDFAKVCSSTQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNkRCKEDEK
|.|| ...   .. .   ... ||||.|| |||.| |||  ..||  .||..|| .|.||.. |.|||.|.|. ...||.||..||.| . . |..||||
eegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvgllls.rsledek

LVNSALG---SMKKGMIVDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEACfDQNLSMNAYLSRLESCGWMDQIQAVLGTAC
|... |.   . .|..|||.|..  ..  | .||| |.|..||...    ||..  |. .|. ||..|| ... ..  .||.||..||.|.|. .| .|.
lleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdslnllslleesgwldliklilelav

YVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFE
.....|. .. .||||.  | | | |..||.|..|||..||..|||.|. .||.  ||.|..|. . . |... |.  ||||||||||||...|||..||
livklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh.leseidskefsPvFllFLdcvwqLlrqfPtaFe

FHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDEILedMLNPMYERNES-VLWPSVAPQSLVLWPGLYLKWQ
| . .|. |..|.|...|||||.|.|| |.. .. |.|.||||||.. .     |||.|..... ||.||. ...|.|| ..||.| 
FnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkse..flnplYdpsslevllpslsvldlllWleyylrwl
Myotub-related Myotubularin-like phosphatase domain 109-448 5.1e-120 393.4 Pfam-A 3-351 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 109-448 5.1e-120 393.4 In-house 3-351 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 122-504 8.2e-108 353.1 In-house 4-387 (389) alignment 
Range on Protein: 122-504
Range on HMM: 4-387/389.0
EDGWDMFSNDLDFAKVCSSTQ-SWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDE
||||....   .. .    .. .|||...| .||.| .||. ..||. |||..|| .|.||   |.|||....| .|.|..|. .|| | .|.||.||||
edGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvG.lsgkrskede

KLVNSALGSMKKG---MIVDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEACFDqNLSMNAYLSRLESCGWMDQIQAVLGTA
|... .| . ..    .|.| ||. . .. . ||.| | |..| . .    .|..  |. .|. || |...  |.. . .|| |||  |...|...| .|
kylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlp.nvddkkwlsalestkWlehiklilaga

CYVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSF
  ......|  . ||||   | | | |.|||....||.  ||..||. |...||.  ||.|..| .. | .... . ..|||| |.|||||. .|||. |
vkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlgh.gdknssdaersPvFlqfiDcvwqltrqfptAF

EFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDEilEDMLNPMYERN--ESVLWPSVAPQSLVLWPGLYLKWQ
|| ..|||.| .| | . |||||.|.||.||  |.||||.|||||.|...  |.  ||.|...  ..|| | .. ..| ||   ||.|.
efneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnssk..eeftnplyaeelekkvlypkaslrrlelWkeyylrwn
subfamily_MTMR6_pd Subfamily MTMR6 119-504 3.7e-106 347.7 In-house 13-396 (397) alignment 
Range on Protein: 119-504
Range on HMM: 13-396/397.0
LSGEDGWDMFSNDLDFAKVCSSTQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSnkRCKE
 . ..||....   .....  . ..| ....| .||.| .||... ||  .. . | .|..||   |.||| |.||.... . |. .||.|  .  ||.|
eekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa..rcle

DEKLVNSA---LGSMKKGMIVDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEACFDQNLSMNAYLSRLESCGWMDQIQAVLG
||||..       . .  ..||||     .  ...| | | |.||   |   ..||   |. .|. ||.|..  .. |....|| |||.||.  |.||| 
deklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavld

TACYVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRCTRVgfsSTKYKGQGPVFLLFLDCVWQIYQQFPC
.....|. ....|. ||||   | | | ||.||....|||  ||..||. |...||.  || ||.||  .   ... |   |.|. ||.||||. .|||.
asifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll...dedskevsPiftqflecvwqlleqfpk

SFEFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDEilEDMLNPMYERNES--VLWPSVAPQSLVLWPGLYLKWQ
.||| ..||. | .| | .||||||.|.||.|   ||||.| |||.|| ...  .| |||.|. ...  ||.|..||..| || .|| ...
afefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerk..ddylnplykaetekevlkpdtapaalklwralynrfd
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 122-504 4.4e-101 330.9 In-house 13-403 (404) alignment 
Range on Protein: 122-504
Range on HMM: 13-403/404.0
EDGWDMFSNDLDFAKVCSSTQ-SWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDE
|||| ....  ....   ...  ||||..|..||.| .||  ..||  .||.||| .|.||.  |.|||.. |. ..|...||  || | ....|..|||
edgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvG.ltksrseedE

KLVNSAL---GSMKKGMIVDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEACFDQNLSMNAYLSRLESCGWMDQIQAVLGTA
||.||      .... .|.|.|..   .....|| | |  |.| . . .  |||.   | .|. || .|. . . . . .||.||| .|.|.|. .| ..
klinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegs

CYVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRCTRvgFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSF
  ... ..... .||||   |.|.| |..||||..|||  ||..||..|...||.  || | .|...   .... . . |.|| |.|||.|. .||| ||
kriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq..ttekssdersPiflqFidcvyqltkqfptsF

EFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDEilEDMLNPMY----ERNESVLWPSV-----APQSLVLWPGLYLKWQ
|| ..||| . .. | ..|||||...||.|.  .|...|.|||..|....  ...|||.|    .....    |       .. . ||  .||.|.
eFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleank..seylnplyilekkeqkenitssessssadikliklWseyylrwr
subfamily_MTMR3_pd Subfamily MTMR3 229-502 1.6e-71 234.4 In-house 171-441 (442) alignment 
Range on Protein: 229-502
Range on HMM: 171-441/442.0
SMKKGMIVDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEACFdQNLSMNAYLSRLESCGWMDQIQAVLGTACYVAHCLHTDG
  || .||| ||  | .  |.||||.| |  ||. .    ..     .  |  .| . .  |    . .||.||.  |. ..  .| .|  |.. ....|
ekkkllivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkeg

IPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLF
 |||||   | | | |...|....|||  ||..||. ||.|||.  || |..||.  |  . . . . |||| .||.| |. .|||.|||| ..||. | 
rpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcgh.genvddanercPvflqwldavhqlqrqfPtsfefneaflvklv

EHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDEilEDMLNPMYER-NESVLWPSVAPQSLVLWPGLYLK
.|.| . |||||.|.||.| . |.||.|.|.||.|...|  ... | .|.. .| ||.|.|  ..| ||  .||.
qhtysclfGtflansekereeekvkertlsvWsllrake..keyrnllykekteavllpavsvrelklwsevyle
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 138-502 6e-62 201.7 In-house 36-403 (405) alignment 
Range on Protein: 138-502
Range on HMM: 36-403/405.0
CSSTQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDEKLV-NSALGSMKKGM-I
 ||.  |... .| .|..|.||..|..|     | .|.    ||   | | | .   .... . |  .|| | .   || |||  . . || .  | . .
nssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvg.ierarcpedelycsslalsapsktlyl

VDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEAC----FDQNL--SM-NAYLSRLESCGWMDQIQAVLGTACYVAHCLhTDG
.|.|     .   ..| |.|   |||. |    || .  |.  |. ||. |      |..   |    .   .|  ||. .|...| .| . |. .   |
idarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkg

IPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRctrVGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLF
  .|||   | | | |.|||.|..|||  ||. ||| |...||.  || || |   .|    . . . |.|  ||||..|. .|||  |||  |.|. . 
nsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslr...lghlpgneeerspifqqfldccfqllsqfpllfeftpslllfis

EHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDeiLEDMLNPMYERNE-SVLWPSVAPQSLVLWPGLYLK
.  .  ..|||| | ||.||  ..| ||||.|| .| .  .. .||| |. ..   . | .  . | ||   |..
dnihsckygtflnncekdrvqdqvktktisiwsevnln..vnkflnpyynpqdiqsikpklysrclelwkacymr
subfamily_MTMR10_pd Subfamily MTMR10 283-472 8.4e-51 164.9 In-house 136-311 (380) alignment 
Range on Protein: 283-472
Range on HMM: 136-311/380.0
LMEACFDQNLS-----MNAYLSRLESCGWMDQIQAVLGTACYVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHP
|.| |  ..        . .|| ||. .|.. ....| ||  ......... .|.. .  | |  . | ||.|..||| .|| .|||||...||. .|||
lreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghp

FSNRCTRVGFSSTKYKgqgPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKtislwsylnqdeiledM
| .|. ..  |... .   ||||||||||.|  .||| .||| ..||| |. . . . |.|||.|.|..|.. . . .                .
fldrlghikpsekses...pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsss................p
subfamily_MTMR5_pd Subfamily MTMR5 278-497 1.4e-46 151.3 In-house 243-476 (483) alignment 
Range on Protein: 278-497
Range on HMM: 243-476/483.0
DSVCKLMEACFDQNL----SMNAYLSRLESCGWMDQIQAVLGTACYVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIR
 |  ||. ||. ..     .....|. .|   |. ||...|  .  |.  |  .|  |||   .| |.| ||.||.|..|||  ||. ||. ||..||. 
asfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLa

GGHPFSNRCTRVGFSSTKykGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKL----------KEKTISLWSYL
 || |..|....  ...   |  |||| |||||.|. .||| .||| | .|  |  |    .| ||| . |..|.   |          |. ..|.| |.
fGHrFtkrsnqtlsaqss..gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyi

NQDEILED-MLNPMYER-NESVLWPSVAPQSLVLWP
.. .       | .|.  .. || ||.   || .|.
drqhkrspifynflyspdesevlrPssnvsslkvWd
subfamily_MTMR3_pd Subfamily MTMR3 140-227 1.6e-25 82.8 In-house 40-126 (442) alignment 
Range on Protein: 140-227
Range on HMM: 40-126/442.0
STQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSnKRCKEDEKLVNSAL
 ...||||.|| ....|.|||. .|||  ..||.|| .|.||   |.|.. . || ...||.|.. |  | ..  |..|||||.... 
lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlg.Wrnaedekllkaia
subfamily_pats1_pd Subfamily pats1 393-467 3e-22 70.8 In-house 550-624 (691) alignment 
Range on Protein: 393-467
Range on HMM: 550-624/691.0
KGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDE
..  |.|. ||| |||....||  ||| .|.|. | .... |.||.||... |...  |. ... |.||. ||..
rsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnk
subfamily_MTMR5_pd Subfamily MTMR5 136-212 7.2e-19 59.9 In-house 23-99 (483) alignment 
Range on Protein: 136-212
Range on HMM: 23-99/483.0
KVCSSTQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMS
. .|.....|||.|| .|.|| |||  ..||  ||||...  |.  .  |.|| .. |. ....|.|||..   .. 
ngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvv
subfamily_pats1_pd Subfamily pats1 283-383 1.3e-15 48.8 In-house 356-458 (691) alignment 
Range on Protein: 283-383
Range on HMM: 356-458/691.0
LMEACFDQNLSMNAYLSrLESCGWMDQIQAVLGTACYVAHCLHtDGIPVLVHDG-AGLDATLQV---TSLSQVILDPDCRTVRGFQSLVDREWIRGGHPF
|...  . . |.... . .|   |.| .. .| .|  |.  |  .|  ||...   . . .|..   .||.||..||  ||. ||. |...||.. |.||
llqsilsldgsddewke.ieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPf

SNRCT
|... 
skiny
subfamily_MTMR10_pd Subfamily MTMR10 130-223 3.6e-09 27.9 In-house 12-105 (380) alignment 
Range on Protein: 130-223
Range on HMM: 12-105/380.0
NDLDFAKVCSSTQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNKRCKEDEKLV
..|.  .   ...... . .|   ... ..|. ..||  .||....   .  . .|||.... |  ....|. |..    |. ..  .  . ||
erleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekmlelv
subfamily_pats1_pd Subfamily pats1 125-203 4.7e-08 23.9 In-house 6-83 (691) alignment 
Range on Protein: 125-203
Range on HMM: 6-83/691.0
WDMFSNDLDFAKVCSSTQS-WRISHVnINYEVCASYPTSVIVPLGVSDDELKASAQFRHgARFPVLCYFHKATQSVLMRS
.|..|   .. ..  .    ||. .. .. ...  ||  ..||  |||. |..... |.  ..|||.. ... .|.|.| 
fdiyslliegqrlkldldkdwrvvef.lsrdlseiyPkrilvPklvsdellvsyvrkrs.skiPvlswsnqnnksslfri