Gene MTMR9-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR9
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP034_AA protein Get Run
NvecP034_AA_0-263 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR9_pd Subfamily MTMR9 2-166 5.7e-53 172.4 In-house 40-214 (393) alignment 
Range on Protein: 2-166
Range on HMM: 40-214/393.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSmSNKRCKEDEKLVNSALGSMKKGMIVDTRSTPAVMNSRS
|  |.||||||.||||| ...|.||||||.||.|.|||||.|.||.|..||.||..||||| |.|||||||||.|..|...|||.||||||..|..|.||
NknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgs.sgkrckedekllnlvlkklkkGlivdtrsksaaenars

KGLKIALTTPNVLSFKDCHPL-----------LFLWETPHLRLSAPHHASVVQFLIVVVVLFAIVPLEVYLGHCLG
|| .|. .. .. . |....|            .|... ...||. ...| .. . ..  . ... ..... .|| 
kgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcld
0040695 (Phosphotyrosine protein) phosphatases II 1-263 1.6e-52 172.5 In-house 32-385 (388) alignment 
Range on Protein: 1-263
Range on HMM: 32-385/388.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNkRCKEDEKLVNSALG---SMKKGMIVDTRSTPAVM
.|  ...| |||  ..||  .||..|| .|.||.. |.|||.|.|. ...||.||..||.| . . |..|||||... |.   . .|..|||.|..  ..
vNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvgllls.rsledeklleailkllpnlskllivdlrpklnal

NSRSKGLKIALTTP--------------------------NVLSFKDCHPLLFLWEtphlrlSAPHHASVVQFLIVVVVLFAIVPLEV--YLGHCLGSR-
  | .| ..  ..                           ..|...| ..|| |.|      .      . ..| ..|... .. |.    | ||   . 
anralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllslle......esgwldliklilelavlivklldlgnssvlvhcsdgwd

----------------------FQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPL
                      ||.|. .||.  ||.|..|. . . |... |.  ||||||||||||...|||..||| . .|. |..|.|...|   |
rtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh.leseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFl

TSCA---------------------------------------------SQQVLWPGLYLKW
  .                                              .. .|| ..||.|
fnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllpslsvldlllWleyylrw
subfamily_MTMR9_pd Subfamily MTMR9 168-253 1.3e-44 144.8 In-house 251-336 (393) alignment 
Range on Protein: 168-253
Range on HMM: 251-336/393.0
RFQSLVDREWIRGGHPFSNRCTRVGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQQ
.|..|..||||..||||..|...|....||.| .|||||||||||.||..|||.||||....||.||||.|.|||.. |.......
gfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaer
Myotub-related Myotubularin-like phosphatase domain 169-252 2e-30 98.8 Pfam-A 266-349 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 169-252 2e-30 98.8 In-house 266-349 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 1-106 2.3e-30 98.5 Pfam-A 46-156 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 1-106 2.3e-30 98.5 In-house 46-156 (353) alignment
subfamily_MTMR10_pd Subfamily MTMR10 169-292 3.1e-26 84.0 In-house 221-348 (380) alignment 
Range on Protein: 169-292
Range on HMM: 221-348/380.0
FQSLVDREWIRGGHPFSNRCTRVGFSSTKYKgqgPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQQVLW-----PGLYL--
||||...||. .|||| .|. ..  |... .   ||||||||||.|  .||| .||| ..||| |. . . . |   |  ...|..       | |    
fqsliqkewvaaghpfldrlghikpsekses...pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliaks

KWQKQQRNGDSFWLEARRVQDLNKDLKLQAA
......   |  . ..   ..  |... .||
elkendllkdeldyrqglyaeiiksirrlaa
subfamily_MTMR1_pd Subfamily MTMR1 169-252 4.5e-25 80.8 In-house 247-329 (389) alignment 
Range on Protein: 169-252
Range on HMM: 247-329/389.0
FQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
|. |...||.  ||.|..| .. | .... . ..|||| |.|||||. .|||. ||| ..|||.| .| | . | . |  . ..
fevliekeWlsfGHkfkeRlgh.gdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnseke
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1-103 1.6e-24 78.8 In-house 41-145 (404) alignment 
Range on Protein: 1-103
Range on HMM: 41-145/404.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDEKLVNSALG---SMKKGMIVDTRSTPAVM
||  ...| .||  ..||  .||.||| .|.||.  |.|||.. |. ..|...||  || | ....|..|||||.||      .... .|.|.|..   .
insdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvG.ltksrseedEklinsirkaktqletlyildarpkanav

NSRSKG
....||
ansakg
subfamily_MTMR3_pd Subfamily MTMR3 168-250 5.5e-23 74.4 In-house 303-384 (442) alignment 
Range on Protein: 168-250
Range on HMM: 303-384/442.0
RFQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCA
 |. ||.|||.  || |..||.  |  . . . . |||| .||.| |. .|||.|||| ..||. | .|.| . | . |. ..
GfkvlvereWldfGhkfadrcgh.genvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflanse
subfamily_MTMR6_pd Subfamily MTMR6 169-251 3.4e-22 71.3 In-house 258-337 (397) alignment 
Range on Protein: 169-251
Range on HMM: 258-337/397.0
FQSLVDREWIRGGHPFSNRCTRVgfsSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCAS
|. |...||.  || ||.||  .   ... |   |.|. ||.||||. .|||..||| ..||. | .| | .|| . |. |  
flvliekewlsfGhkfsercGll...dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncek
subfamily_MTMR1_pd Subfamily MTMR1 1-103 1.1e-21 69.6 In-house 32-136 (389) alignment 
Range on Protein: 1-103
Range on HMM: 32-136/389.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDEKLVNSALGSMKKG---MIVDTRSTPAVM
.|  ...| .||. ..||. |||..|| .|.||   |.|||....| .|.|..|. .|| | .|.||.|||||... .| . ..    .|.| ||. . .
lnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvG.lsgkrskedekylqaileanaqsekllildarssvnav

NSRSKG
. . ||
ankakg
subfamily_MTMR5_pd Subfamily MTMR5 169-252 2.1e-21 68.3 In-house 332-413 (483) alignment 
Range on Protein: 169-252
Range on HMM: 332-413/483.0
FQSLVDREWIRGGHPFSNRCTRVGFSSTKykGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
|. ||..||.  || |..|....  ...   |  |||| |||||.|. .||| .||| | .|  |  |    .|   |. .  .
FkvLveKEWLafGHrFtkrsnqtlsaqss..gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseye
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 169-252 5.1e-21 67.3 In-house 257-338 (404) alignment 
Range on Protein: 169-252
Range on HMM: 257-338/404.0
FQSLVDREWIRGGHPFSNRCTRvgFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
|..|...||.  || | .|...   .... . . |.|| |.|||.|. .||| |||| ..||| . .. | ..|   |  .  .
FivliekewlsfGhkfaqRigq..ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydseke
subfamily_MTMR3_pd Subfamily MTMR3 2-82 2.3e-20 65.8 In-house 50-129 (442) alignment 
Range on Protein: 2-82
Range on HMM: 50-129/442.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSnKRCKEDEKLVNSALGSM
|  |..|.|||. .|||  ..||.|| .|.||   |.|.. . || ...||.|.. |  | ..  |..|||||....  . 
nsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlg.Wrnaedekllkaiakac
subfamily_MTMR6_pd Subfamily MTMR6 2-102 8.8e-19 60.0 In-house 44-145 (397) alignment 
Range on Protein: 2-102
Range on HMM: 44-145/397.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSnkRCKEDEKLVNSAL---GSMKKGMIVDTRSTPAVMN
|  ...| .||... ||  .. . | .|..||   |.||| |.||.... . |. .||.|  .  ||.|||||..       . .  ..||||     . 
nkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa..rcledeklleairkanpnsellyvvdtrpklnala

SRSK
 ...
nkaa
subfamily_MTMR5_pd Subfamily MTMR5 1-66 1.7e-13 42.2 In-house 36-101 (483) alignment 
Range on Protein: 1-66
Range on HMM: 36-101/483.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNK
.|  ..|| |||  ..||  ||||...  |.  .  |.|| .. |. ....|.|||..   .. ..
vNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 168-253 5.6e-13 40.4 In-house 267-349 (405) alignment 
Range on Protein: 168-253
Range on HMM: 267-349/405.0
RFQSLVDREWIRGGHPFSNRctrVGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQQ
 || |...||.  || || |   .|    . . . |.|  ||||..|. .|||  |||  |.|. . .  .  .. . |  |  ..
gfqvliekewlsfghkfslr...lghlpgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdr
subfamily_pats1_pd Subfamily pats1 199-250 7.3e-12 36.5 In-house 550-601 (691) alignment 
Range on Protein: 199-250
Range on HMM: 550-601/691.0
KGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCA
..  |.|. ||| |||....||  ||| .|.|. | .... |.| . | | |
rsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflysea
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1-93 1.3e-09 29.3 In-house 47-140 (405) alignment 
Range on Protein: 1-93
Range on HMM: 47-140/405.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDEKLV-NSALGSMKKGM-IVDTRST
||  ...|.||..|..|     | .|.    ||   | | | .   .... . |  .|| | .   || |||  . . || .  | . ..|.|  
inkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvg.ierarcpedelycsslalsapsktlylidarpk
subfamily_MTMR10_pd Subfamily MTMR10 2-75 1.6e-07 22.4 In-house 32-105 (380) alignment 
Range on Protein: 2-75
Range on HMM: 32-105/380.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNKRCKEDEKLV
| .|... ..|. ..||  .||....   .  . .|||.... |  ....|. |..    |. ..  .  . ||
nelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekmlelv
subfamily_pats1_pd Subfamily pats1 6-55 5.2e-06 17.1 In-house 35-83 (691) alignment 
Range on Protein: 6-55
Range on HMM: 35-83/691.0
QVCASYPTSVIVPLGVSDDELKASAQFRHgARFPVLCYFHKATQSVLMRS
...  ||  ..||  |||. |..... |.  ..|||.. ... .|.|.| 
dlseiyPkrilvPklvsdellvsyvrkrs.skiPvlswsnqnnksslfri