Gene DSP23 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP23
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP015_AA protein Get Run
SpurP015_AA_7-152 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP23_pd Subfamily DSP23 6-153 2e-92 301.5 In-house 1-148 (148) alignment 
Range on Protein: 6-153
Range on HMM: 1-148/148.0
PPPFFTWVSSNLAAHGMPSSPDQMRYLADNGIRYLISLTTECRPPVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGT
.||||.||||.|||...|..|||.|||.|.|.|||.|||.|.||.||||||.|.|...|||||||.|||||||.||.|||||||||||||||.|||||||
qppffswvssrlaalalprlpdqyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgt

MVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETFINKP
|.|||..|..|..|||||||||..|||||||||||.|.|||||||||.
mlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfinkt
0046846 (Phosphotyrosine protein) phosphatases II 5-150 4.2e-37 122.9 In-house 7-172 (176) alignment 
Range on Protein: 5-150
Range on HMM: 7-172/176.0
TPPPFFTWVSSNLAAHGMP---------SSPDQMRYLADNGIRYLISLTTE---------CRPPVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAE
.........  ||.. ..|         . .|  ..| ..||.....||.|           .|.. ......  ....|...|.||.. |... ..|| 
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefireal

EKNEAVSVHCLRGRGRTGTMVACYFIKM-QKMSAAEAIAEVRHQRP-GSVETVEQENLIRDYETFI
.... | |||  |.|||||.||.| ..  . .|. ||.|.|| ||| |.|.| ||   ....| ..
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0048179 (Phosphotyrosine protein) phosphatases II 7-148 1.2e-34 114.5 In-house 1-142 (144) alignment 
Range on Protein: 7-148
Range on HMM: 1-142/144.0
PPFFTWVSSNLAAHGMPsSPDQMRYLADNGIRYLISLTTECRPPVEATPNVTWVPIGIDDYHPPTL-EQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGT
|...... ..|   ..| .. .. .|...||...|.||.|. |. .  ...... ....|...|.| |.. ||.. .||| |... | |||  |.|||||
psnpseilpglylgslp.taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgt

MVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYET
.||.| .|....|. ||.|.|| .|||.|.. .| . ...||.
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0044763 (Phosphotyrosine protein) phosphatases II 5-151 9.7e-34 111.9 In-house 18-171 (178) alignment 
Range on Protein: 5-151
Range on HMM: 18-171/178.0
TPPPFFTWVSSNLAAHGMPSsPDQMRYLADNGIRYLISLTTECRPPVEATPN-------VTWVPIGIDDYHPPT-LEQVVEFMRVMEEAE-EKNEAVSVH
.... ....  .| . . |. .|  ..| ..||.....||.|.... . ..        .... |.|.|...|. ||.. ||.. .|||  ||...| ||
sdyinaseilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPgSVETVEQENLIRDYETFIN
|  |.||.||.||.| .|....|. |||..|| .||  |.. .| . ....| ...
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0048076 (Phosphotyrosine protein) phosphatases II 7-149 4e-33 109.5 In-house 1-141 (145) alignment 
Range on Protein: 7-149
Range on HMM: 1-141/145.0
PPFFTWVSSNLAAHGMPsSPDQMRYLADNGIRYLISLTTECRPPVeaTPNVTWVPIGIDDYHPPTL-EQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGT
|......  .|   ..| .. ....|.|.||.....||.|.. ..    ..... ....|...|.| |.. ||.. .||| .... | |||  |.|||||
pywpseilpglylgslp.taldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgt

MVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETF
.||.| ......|. ||...|| ||||.|....| . ....|. 
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0043147 (Phosphotyrosine protein) phosphatases II 25-150 1.8e-32 107.8 In-house 33-160 (172) alignment 
Range on Protein: 25-150
Range on HMM: 33-160/172.0
SPDQMRYLADNGIRYLISLTTE-CRPPVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEE--AEEKNEAVSVHCLRGRGRTGTMVACYFIKmQKMSAAE
 .|  |.| ..||.....||.. . |. .   ....  ....|...|.||.. ||.. ..|  |......| |||  | |||||.||.| .. ...|. |
ladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglslee

AIAEVRHQRPGSVETVEQENLIRDYETFI
|.|.||..|||.|.. .| ......| ..
avalvrekRpgavqnpsqyrflyyfekll
0036282 (Phosphotyrosine protein) phosphatases II 10-150 3.8e-32 106.7 In-house 12-169 (174) alignment 
Range on Protein: 10-150
Range on HMM: 12-169/174.0
FTWVSSNLAAHGMPSSpdQMRYLADNGIRYLISLTTECRP-------------PVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAEEK--NEAVSV
.......| | . | .   ...| ..||.....|..|. .               .   ..... ....|...|.|... ||.. .||| ..  .  | |
lsyitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlV

HCLRGRGRTGTMVACYFIKMQKM-SAAEAIAEVRHQR---PGSVETVEQENLIRDYETFI
||  |.|||||.||.| ...... |. .|.. || .|   ||.|.| .|   ....| ..
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0041856 (Phosphotyrosine protein) phosphatases II 8-148 5.4e-32 106.2 In-house 17-168 (182) alignment 
Range on Protein: 8-148
Range on HMM: 17-168/182.0
PFFTWVSSNLAAHGMPSS-------------PDQMRYLADNGIRYLISLTteCRP---PVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEaeeKNEA
......  || . ..|..             .|  |.| ..||.....||  ...     .   ..... ....|...|.|.....|.. ..|   ....
rdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle...eggp

VSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYET
| |||  |.|||||.||.|..| ...|. ||...|| .|||.|.| .|  ...... 
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlall
PTEN_1 27-149 3.6e-31 103.5 In-house 58-191 (196) alignment 
Range on Protein: 27-149
Range on HMM: 58-191/196.0
DQMRYLADNGIRYLISLTTECRP-------PVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAEEK---NEAVSVHCLRGRGRTGTMVACYFIKMQK
.  . |  .||. ...|. |.           .   .|.. ...|.|...|.|... .. ....|.  .   ...| |||  |.||.||.||.| .. .|
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

MSAAEAIAEVRHQR-PGSVETVEQENLIRDYETF
..| ||.. || .| ||.... .|| |.. .. .
ltadeAlelvrekRppgapnspsqerlleyfael
0049260 (Phosphotyrosine protein) phosphatases II 25-149 1.1e-30 101.8 In-house 22-148 (152) alignment 
Range on Protein: 25-149
Range on HMM: 22-148/152.0
SPDQMRYLADNGIRYLISLTTECRPPVEATP-NVTWVPIGIDDYHPPTLEQVVEFMRVMEEA--EEKNEAVSVHCLRGRGRTGTMVACYFIKmQKMSAAE
 .|  |.| ..||.....||...  . . ..   ..  . ..|...|.|.|...|.  . |   ..|.. | |||  | |||||.||.| .. ...|. |
ladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvslee

AIAEVRHQRPGSVETVEQENLIRDYETF
|.| || .|||.|.. .|  .. ..|..
avalvrekRpgavpnpgqlrflyefekl
0051082 (Phosphotyrosine protein) phosphatases II 5-140 2e-30 100.7 In-house 3-142 (151) alignment 
Range on Protein: 5-140
Range on HMM: 3-142/151.0
TPPPFFTWVSSNLAAHGMPsSPDQMRYLADNGIRYLISLTTECRPPVEATP----NVTWVPIGIDDYHPPTL----EQVVEFMRVMEEaeEKNEAVSVHC
.... |..| ..| . |.| ..|....|...||.. ..|..|  .. .. .    ..... | |.| ..|.|    ..|.||......   ||  | |||
sdyinfsyvtgglyrsggp.ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld..kkngpvlvHC

LRGRGRTGTMVACYFIKmQKMSAAEAIAEVRHQRPGSVETVEQE
  |.|||||.||.| .. ...|..||..|.| .|||.| . .| 
saGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqf
0042113 (Phosphotyrosine protein) phosphatases II 25-148 8.9e-30 99.3 In-house 65-240 (245) alignment 
Range on Protein: 25-148
Range on HMM: 65-240/245.0
SPDQMRYLADNGIRYLISLTTECR--------------------------------------------PPVEATPNVTWVPIGIDDYHPPT-LEQVVEFM
 .|  |.| ..||.....||.|                                              .  |   ....  ....|...|. ||....|.
vedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfl

RVMEEAEE--KNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYET
. ...| .  .|. | |||  |.|||||..|.| .     | ...|. ||..|.| ||||.|.| .|   ..... 
efvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 10-149 1.1e-29 99.1 In-house 39-240 (243) alignment 
Range on Protein: 10-149
Range on HMM: 39-240/243.0
FTWVSSNLAAHGMPSSP---D----QMRYLADNGIRYLISLTTEC------------------------------------------RP-PVEATPNVTW
...|  .| | ..| .    |      |.| ..||.....||...                                           . . .   .. .
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

VPIGIDDYHPPT-LEQVVEFMRVMEE---------AEEKNEAVSVHCLRGRGRTGTMVACYFIKMQ-KMSAAEAIAEVRHQRPG-SVETVEQENLIRDYE
  ... |...|.  |....|.. . |         |. ... | |||  |.|||||..|.| .... .... ||....| |||| .|.| .|   .....
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

TF
 .
le
0045098 (Phosphotyrosine protein) phosphatases II 25-148 2.1e-28 94.9 In-house 77-269 (278) alignment 
Range on Protein: 25-148
Range on HMM: 77-269/278.0
SPDQMRYLADNGIRYLISLTTECRP-----------------------------------------------PVEATPNVTWVPI-GIDDYHPPTLE---
  |  |.| ..||.....||..                                                  .   . .||.. . ...|...|.|.   
vadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilk

QVVEFMRVMEEAEE--------------KNEAVSVHCLRGRGRTGTMVACYFIKMQ---KMSAAEAIAEVRHQRPG-SVETVEQENLIRDYET
.. |... ..|| .              ... | |||  | |||||.||.| .. .   .... ||..|.| |||| .|.. || . . ... 
sflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0039614 (Phosphotyrosine protein) phosphatases II 29-149 1.5e-27 92.2 In-house 118-287 (297) alignment 
Range on Protein: 29-149
Range on HMM: 118-287/297.0
MRYLADNGIRYLISLTTECRPP-----------------------VEATPNVT-----------------WVPIGIDDYHPP-TLEQVVEFMRVMEEAEE
 |.. ..|......||...                          ||  ...|                 .  .|. |...| .||.. ||.. ..|| .
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---KNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETF
   |.. | |||  | |||||..|.| .     | ..... ||..|.| ||||.|.| .|   ..|.. .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0038934 (Phosphotyrosine protein) phosphatases II 11-152 2.3e-27 91.3 In-house 14-178 (194) alignment 
Range on Protein: 11-152
Range on HMM: 14-178/194.0
TWVSSNLAAHGMPSSPDQMRYL-----------------ADNGIRYLISLTTECR-PPVEATP--NVTWVPIGIDD-YHPPTLEQVVEFMRVMEEAEE--
...  .. | ..|.|    .|.                    .....|.|| . |   .|  .  ..... . . | ...|.||.. .|.....|  .  
diitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned

KNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETFINK
....| |||  |.|||||.||.| |....||| |||| .|  |||....... . .. .  ...|
pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
0040439 (Phosphotyrosine protein) phosphatases II 25-148 3.9e-27 90.9 In-house 67-243 (249) alignment 
Range on Protein: 25-148
Range on HMM: 67-243/249.0
SPDQMRYLADNGIRYLISLTTECRP-------------------------------------------PVEATPNVTWVPI-GIDDYHPP-TLEQVVEFM
 .|  |.| ..||.....||.....                                               .  |..... .. |.. | ..|....|.
vedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfi

RVMEEAEE---KNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYET
. ...| |   |.. | |||  | |||||..|.| .     | ..... ||....|.||||.|.. ||   . ... 
eavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0051429 (Phosphotyrosine protein) phosphatases II 19-148 4.2e-27 90.9 In-house 28-222 (272) alignment 
Range on Protein: 19-148
Range on HMM: 28-222/272.0
AHGMPSSPDQMRYLADNGIRYLISLTTEC----RPPVEATPNVTWVPIGIDDYHPPTL------------------------------------------
.. .| .... ..|...||.. ..|..|.     .     |..... . | |...||                                           
ggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

----------EQVVEFMRVMEEaeekNEAVSVHCLRGRGRTGTMVACYFIKmQKMS--------------AAEAIAEVRHQRPGSVETVEQENLIRDYET
          |...|..... .    ...| |||  |..||||.||.. .  . .|              ..||..|.| ||||.|.| ||   ..... 
tdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall
0040438 (Phosphotyrosine protein) phosphatases II 28-148 5.3e-27 90.3 In-house 102-273 (317) alignment 
Range on Protein: 28-148
Range on HMM: 102-273/317.0
QMRYLADNGIRYLISLTTECRPPV--------------------------EaTPNVTWVPIGI-------------------DDYHPP-TLEQVVEFMRV
  |.. ..|......||... . .                          |  ...|.  . .                   .|...| .......|.. 
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

MEEAEEK-NEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYET
..|| |. .. | |||  | |||||..|.| .     | ..... ||..|.|.||||.|.| ||   . |.. 
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall
0045450 (Phosphotyrosine protein) phosphatases II 29-148 2.8e-26 88.4 In-house 124-301 (307) alignment 
Range on Protein: 29-148
Range on HMM: 124-301/307.0
MRYLADNGIRYLISLTTECRP---------------------------------------------PVEATPNVTWVPI-GIDDYHPP-TLEQVVEFMRV
 |.| ..|......||...                                               . . .  ||  .  |  |.. | ..|....|.. 
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

MEEAEE---KNEAVSVHCLRGRGRTGTMVACYFIKMQK--------MSAAEAIAEVRHQRPGSVETVEQENLIRDYET
...| |   |.. | |||  | |||||..|.| .. |         ... ||....| ||||.|.. ||   ..... 
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0049772 (Phosphotyrosine protein) phosphatases II 30-144 2.9e-26 88.4 In-house 156-273 (314) alignment 
Range on Protein: 30-144
Range on HMM: 156-273/314.0
RYLADNGIRYLIsltTECR-PPVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAeEKNEAVSVHCLRGRGRTGT-MVACYFIKMQKMSAAEAIAEVR
 ..    . .|    .|.  |.    ...... | ..|...|.||.. ||....||| .|...| |||  |.||||| .||.| .| ...|..||...||
neptaadlellk...eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvr

HQRP-----GSVETVEQENLIR
 .||     |..|. ||   | 
lkRpinpnpgfieqleqyefil
0043336 (Phosphotyrosine protein) phosphatases II 29-147 1.7e-25 85.5 In-house 105-273 (278) alignment 
Range on Protein: 29-147
Range on HMM: 105-273/278.0
MRYLADNGIRYLISLTTEC--------------------------------------------RPPVEATPNVTWVpIGIDDYHPP-TLEQVVEFMRVME
 |.. ..|.. ...||..                                             . . . | .. .  .|. |.. | .|.....|.... 
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy.lgwpdhgvpeslsllldflkavr

EAEE-KNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYE
|| | .|..| |||  | |||||..|.| .     | ..... ||..|.|.||||.|.| .|   .....
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_PTPDC1_pd Subfamily PTPDC1 56-151 1.1e-24 81.9 In-house 82-176 (182) alignment 
Range on Protein: 56-151
Range on HMM: 82-176/182.0
NVTWVPIGIDDYHPPTLEQVVEFMRVMEEAEEKNeAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETFIN
....  .|..||  ..||.... ..|.. | ... .|.|||  |.|||| ..|||.. .....|..||  ||..|| |..| || .|......|. 
giyvynfgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfli
0036941 (Phosphotyrosine protein) phosphatases II 61-148 1.3e-21 72.6 In-house 175-274 (297) alignment 
Range on Protein: 61-148
Range on HMM: 175-274/297.0
PIGIDDYHPPT-LEQVVEFMRVMEEAEE---KNEAVSVHCLRGRGRTGTMVACYFI--------KMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYET
 .|..|...|.  .....|.. .... .   ... | |||  | ||.||..|.. .        | ....  ||. ..|.||||.|.|.||   ..... 
ytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
0047943 (Phosphotyrosine protein) phosphatases II 30-143 2.1e-21 72.0 In-house 95-264 (273) alignment 
Range on Protein: 30-143
Range on HMM: 95-264/273.0
RYLADNGIRYLISLTTECRPPVE---------A--------------------------------------TPNVTWVPIGIDDYHPP-TLEQVVEFMRV
|.. ....|....||..     |                                                     .   |. |.. | .||...||...
rmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

MEEAEE---KNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLI
...| |   .|. | |||  | |||||..|.. .     | ..... ||.. .| ||||.|.|.||  ..
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 62-145 3.6e-21 71.2 In-house 173-268 (284) alignment 
Range on Protein: 62-145
Range on HMM: 173-268/284.0
IGIDDYHPP-TLEQVVEFMRVMEEAEEK---NEAVSVHCLRGRGRTGTMVACYFIKMQ--------KMSAAEAIAEVRHQRPGSVETVEQENLIRD
... |.. | ..|...||.| ..|. |.   .. . |||  | |||||..|.. .. |        .... ||.. .| ||||.|.|.||  .. .
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye
0050432 (Phosphotyrosine protein) phosphatases II 64-143 1.1e-20 69.7 In-house 207-291 (308) alignment 
Range on Protein: 64-143
Range on HMM: 207-291/308.0
IDDYH-PPTLEQVVEFMRVMEEAEeKNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLI
  |.. || .|....|.. ...   ... . |||  | |||||..|.. .     | ..... ||.. .|.||||.|.|.||  ..
WpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
0048567 (Phosphotyrosine protein) phosphatases II 64-149 1.7e-20 67.9 In-house 46-137 (157) alignment 
Range on Protein: 64-149
Range on HMM: 46-137/157.0
IDDYhPPTLEQVVEFMRVMEEAEE----KNEAVSVHCLRGR---GRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETF
 |.  |..| ....|......  .    .. |. |||  |.   |||.|...|| |. ......|||| .|  |||||   .. .|...|.  
fdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynlt
0051299 (Phosphotyrosine protein) phosphatases II 62-143 1e-19 66.6 In-house 190-278 (288) alignment 
Range on Protein: 62-143
Range on HMM: 190-278/288.0
IGIDDYHPPT-LEQVVEFMRVMEEA-EEKNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLI
... |.. |. .|....|.| . .| . ..  | |||  | |||||..|.. .     | ..... ||.. .|.||||.|.|.||  ..
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
DSPc Dual specificity phosphatase, catalytic domain 29-147 3.7e-19 63.9 Pfam-A 11-131 (133) alignment 
Range on Protein: 29-147
Range on HMM: 11-131/133.0
MRYLADNGIRYLISLTTECRPPVE---ATPNVTWVPigIDD----YHPPTLEQVVEFmrvMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAE
 . |...|| . |..|.|.. . .      . ...|  ..|       . ||..|||   .|.||.|.. | |||  |  |..|....| .| ...|. |
lalleklgitlvinvtkevpnnnaikkseieylrip..vedetetkiskeleeavef...iekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslne

AIAEVRHQRPGSVETVEQENLIRDYE
|.. |. .|.  ......   ...||
AyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 29-147 3.7e-19 63.9 In-house 11-131 (133) alignment 
Range on Protein: 29-147
Range on HMM: 11-131/133.0
MRYLADNGIRYLISLTTECRPPVE---ATPNVTWVPigIDD----YHPPTLEQVVEFmrvMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAE
 . |...|| . |..|.|.. . .      . ...|  ..|       . ||..|||   .|.||.|.. | |||  |  |..|....| .| ...|. |
lalleklgitlvinvtkevpnnnaikkseieylrip..vedetetkiskeleeavef...iekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslne

AIAEVRHQRPGSVETVEQENLIRDYE
|.. |. .|.  ......   ...||
AyefvkerrskispnagflrqLleye
PTPc_motif_SM00404 29-139 8.9e-19 62.8 In-house 20-130 (140) alignment 
Range on Protein: 29-139
Range on HMM: 20-130/140.0
MRYLADNGIRYLISLTTECRPPvEATPNVTWVPIGIDD-YHPPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVR
 . |. .||.. |..|.|.. . ....... . | .||    .....  . ....|.||.|...| |||  |  |..|....| .. ...|.|||.  |.
pallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvk

HQRPGSVETVEQ
..||   .... 
erRpiispnlnf
subfamily_CDC14_pd Subfamily CDC14 69-146 1.6e-18 61.7 In-house 246-320 (328) alignment 
Range on Protein: 69-146
Range on HMM: 246-320/328.0
PPTLEQVVEFMRVMEEAeekNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDY
 |. . | .|....|.|   . |..|||  | |||||..|||..|  ...|||||| .|  ||||| .  |. |..  
tPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfleekq
subfamily_PTPMT1_pd Subfamily PTPMT1 56-150 6.6e-18 59.7 In-house 73-168 (171) alignment 
Range on Protein: 56-150
Range on HMM: 73-168/171.0
NVTWVPIGIDDYH-PPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETFI
.|. . . . |.   |.||.. . ....|.  .| . | |||  ||||..|.|||| .|..|.|  ||.  ....|.      .| .... ||...
gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_PTEN_pd Subfamily PTEN 62-151 8.7e-15 50.2 In-house 85-180 (184) alignment 
Range on Protein: 62-151
Range on HMM: 85-180/184.0
IGIDDYHPPTLEQVVEFMRVMEE--AEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAA-EA---IAEVRHQRPGSVETVEQENLIRDYETFIN
...|| .||.|| . |... .|.  .|.|.. | |||  |.||||.....|..|..... | ||    ||.| .   .|    |   .. ||....
ypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklle
PTPc_DSPc_SM00012 67-143 1.7e-14 49.2 In-house 14-99 (105) alignment 
Range on Protein: 67-143
Range on HMM: 14-99/105.0
YHPPTLEQVVEFMRVMEEAEEKN---EAVSVHCLRGRGRTGTMVACYFIKMQK------MSAAEAIAEVRHQRPGSVETVEQENLI
  | . . ..|..| ... ..|.   . | |||  | |||||.|| . . .|       ..  . . |.|.||||.|.| ||   .
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_RNGTT_pd Subfamily RNGTT 35-150 2.1e-14 47.6 In-house 53-175 (189) alignment 
Range on Protein: 35-150
Range on HMM: 53-175/189.0
NGIRYLISLTTECRPPVEATP---NVTWVPIGIDDYHP-PTLEQVVEFMRVMEE--AEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRH
. ....| || . |.  .      ... | . .  .   |. ||| ||....||  ... .| ..|||  |  ||| ....| .. ...|. .|.|. ..
vklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFak

QRPGSVET-VEQENLIRDYETFI
 ||  .      ..|.| |.   
aRppGiykedylkellrrYadve
subfamily_DSP6_pd Subfamily DSP6 28-131 9.2e-14 45.2 In-house 31-135 (158) alignment 
Range on Protein: 28-131
Range on HMM: 31-135/158.0
QMRYLADNGIRYLISLTTECRPPVEATPNVTWVPIGIDDYHPPTLEQV-VEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEV
..  |.. .|.|.. .|..     | ....... | |.| .   | .   | .. ..|| .|...| |||| |  |. |.. .|..| ...|  .| . |
nlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlv

RHQRP
.....
kkrks
Y_phosphatase Protein-tyrosine phosphatase 68-139 2e-13 45.7 Pfam-A 148-225 (235) alignment 
Range on Protein: 68-139
Range on HMM: 148-225/235.0
HPPTLEQVVEFMRVMEEAE-EKNEAVSVHCLRGRGRTGTMVACYFIKMQK-----MSAAEAIAEVRHQRPGSVETVEQ
 | . .......| .|. . .|.. | |||  | |||||.||  .. .|      ..  ... |.|.||||.|...||
vpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq
Y_phosphatase Protein-tyrosine phosphatase 68-139 2e-13 45.7 In-house 148-225 (235) alignment 
Range on Protein: 68-139
Range on HMM: 148-225/235.0
HPPTLEQVVEFMRVMEEAE-EKNEAVSVHCLRGRGRTGTMVACYFIKMQK-----MSAAEAIAEVRHQRPGSVETVEQ
 | . .......| .|. . .|.. | |||  | |||||.||  .. .|      ..  ... |.|.||||.|...||
vpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq
subfamily_DSP8_pd Subfamily DSP8 30-147 5.9e-12 39.4 In-house 34-151 (159) alignment 
Range on Protein: 30-147
Range on HMM: 34-151/159.0
RYLADNGIRYLISLTTECrPPVEATPNVTWVPIGIDDYHPPTLEQVV-EFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRH
  | ..|| | . . ..| | .|  ... .. . . | .   | ..  . .  .. | ..|  | ||.| |. |  |.. .| .|. .||  ||   |..
ellsklgisyvlnasnsc.pkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvke

QRPGSVETVEQENLIRDYE
.||   . .  .. . .||
krptispnlnflgqLleye
subfamily_DSP12_pd Subfamily DSP12 30-131 8.5e-12 39.7 In-house 21-124 (155) alignment 
Range on Protein: 30-131
Range on HMM: 21-124/155.0
RYLADNGIRYLISLTTECRPPVEATPNVTW-VPIGI-DDYHPPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVR
. |.. .|  ..|...|  |  ..... .    | | |. . . |.   | .. .||| |...|| |||  |  |  |.|. |..| .|.|  .|.  |.
ellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvk

HQRP
...|
ekkp
subfamily_VSP_pd Subfamily VSP 61-123 1.1e-11 39.0 In-house 98-162 (212) alignment 
Range on Protein: 61-123
Range on HMM: 98-162/212.0
PIGIDDYHPPTLEQVVEFMRVMEEA--EEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAI
 | |||.  |.||... | . ..|   ..... . .||  |.|||||.| ..... . .. |.  
riliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakes
subfamily_DSP14_pd Subfamily DSP14 28-131 1.7e-11 38.3 In-house 23-125 (157) alignment 
Range on Protein: 28-131
Range on HMM: 23-125/157.0
QMRYLADNGIRYLISLTTECRPpvEATPNVTWVPIGIDDYHPPTLEQVVE-FMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEV
. ..|. ..|   | .|.|     . ....  | . ..| .  .| .  .  .  .||...|. .. |||  |. |  ...  | .| .|.| .||   |
skellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklv

RHQRP
...||
ksaRp
subfamily_DSP10_pd Subfamily DSP10 29-131 3e-11 37.5 In-house 32-134 (159) alignment 
Range on Protein: 29-131
Range on HMM: 32-134/159.0
MRYLADNGIRYLISLTTECrPPVEATPNVTWVPIGIDDYHPPTLEQVV-EFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVR
.  |   .| ... .||.. |   .  ....  | . | .   |.|   | .  .||| .|.. | |||  |  |  |.|  | .| ...|  .|   |.
ldaldrlnitavlnvttsv.PnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvk

HQRP
..||
ekrp
DSPc_SM00195 68-139 4.2e-11 38.0 In-house 173-250 (263) alignment 
Range on Protein: 68-139
Range on HMM: 173-250/263.0
HPPTLEQVVEFMRVMEEAEE-KNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQ
 | . ..|.|..|.... .. ... . |||  | |||||.|.  .|     . .|..  | . |.|.||||.|.| ||
vpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq
PTPc_SM00194 68-139 4.2e-11 38.0 In-house 173-250 (263) alignment 
Range on Protein: 68-139
Range on HMM: 173-250/263.0
HPPTLEQVVEFMRVMEEAEE-KNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQ
 | . ..|.|..|.... .. ... . |||  | |||||.|.  .|     . .|..  | . |.|.||||.|.| ||
vpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq
subfamily_DSP19_pd Subfamily DSP19 69-132 8.5e-11 36.4 In-house 69-132 (152) alignment 
Range on Protein: 69-132
Range on HMM: 69-132/152.0
PPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPG
   |..  | .  .||| .|. || |||  |. |. ..|  |..| ...|  ||. .||..|| 
tdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc
subfamily_DSP11_pd Subfamily DSP11 80-148 9.3e-11 35.9 In-house 107-172 (178) alignment 
Range on Protein: 80-148
Range on HMM: 107-172/178.0
RVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSvetVEQENLIRDYET
. .|. ..... ..||| .|  ||| ..  |.|... ... .||    . |  |   .|.|| ..| ..
efleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhs...lerenylkdLkk
subfamily_DSP3_pd Subfamily DSP3 75-130 1.5e-10 34.9 In-house 85-138 (162) alignment 
Range on Protein: 75-130
Range on HMM: 85-138/162.0
VVEFMRvmEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQR
...|..  |  ..|.  | |||  |  |  |.|  | . ..||.. ||| .||..|
aakfid..ealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR
subfamily_DSP1_pd Subfamily DSP1 28-133 1.8e-10 35.1 In-house 35-139 (163) alignment 
Range on Protein: 28-133
Range on HMM: 35-139/163.0
QMRYLADNGIRYLISLTTECRPPVEAtpNVTWVPIGIDDYHPPTLEQVV-EFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEV
... |...||  .. ...|.    |     ..  . ..| .   . .|  | .  ..|...||  | .||  |  |  |..  |..| ...|  ||   |
nleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfv

RHQRPGS
...|. .
kqrRsii
subfamily_PRL_pd Subfamily PRL 62-146 2.9e-10 34.4 In-house 61-145 (151) alignment 
Range on Protein: 62-146
Range on HMM: 61-145/151.0
IGIDDYHPPTLEQVVEFMRVMEEA--EEKNEAVSVHCLRGRGRTGTMVACYFIKmQKMSAAEAIAEVRHQRPGSVETvEQENLIRDY
.  ||  .|. | | |......|.  || ...|.|||. | ||.  .||  .|  . |.  .|.  .|..| |.... .| . ...|
lafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrgains.kqlkfleky
subfamily_DSP15_pd Subfamily DSP15 30-146 3.9e-10 34.0 In-house 21-135 (151) alignment 
Range on Protein: 30-146
Range on HMM: 21-135/151.0
RYLADNGIRYLISLTTECRPpveATPNVTWVPIGIDDYHPPTLEQVV-EFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRH
  | .. |  ..|.  . ..     .....  | ..|     |.... | .... ..  |.|.| |||| |  |  |.|. |.. . ...  .|.  ...
elLkeknithilsvhdnakk...llkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevika

QRPGSVETVEQENLIRDY
.|  .   .  .. ...|
aRsvanPnfGfkrqlkey
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 66-144 4.2e-10 34.2 In-house 191-276 (319) alignment 
Range on Protein: 66-144
Range on HMM: 191-276/319.0
DYHPPTLEQVVEFMRVMEEAEEK--NEAVSVHCLRGRGRTGTMVACyFIKMQKMSAAEA------IAEVRHQRPGSVETVEQENLIR
.  | .. ....... .... ||  .  . |||  | ||||| ..  .. .....  ..      . ..| ||.  |.. || ..| 
hdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivl.damlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiy
subfamily_PTPN12_pd Subfamily PTPN12 68-143 9e-10 32.9 In-house 185-269 (290) alignment 
Range on Protein: 68-143
Range on HMM: 185-269/290.0
HPPTLEQVVEFMRVMEEAEEK-NEAVSVHCLRGRGRTGTMVACYFIKM--------QKMSAAEAIAEVRHQRPGSVETVEQENLI
 | . ....|... ..| .|. .. . |||  | |||||..|  ....        ....  . ..|.|.||.  | | || .|.
vPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 72-143 2.5e-09 31.5 In-house 177-256 (270) alignment 
Range on Protein: 72-143
Range on HMM: 177-256/270.0
LEQVVEFMRVME---EAEEKNEAVSVHCLRGRGRTGTMVACYF-----IKMQKMSAAEAIAEVRHQRPGSVETVEQENLI
 .|... .| .    .  .|.| . |||  | |||||..|  .      . .|.  .. |.|.|..|.  |...|| ...
tdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_CDKN3_pd Subfamily CDKN3 72-148 5.4e-09 29.9 In-house 115-193 (202) alignment 
Range on Protein: 72-148
Range on HMM: 115-193/202.0
LEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQ-KMSAAEAIAEVRHQR-PGSVETVEQENLIRDYET
  . ....  .  . ..     |||  | ||.  ..|| .. ..  ..  .||...|. .  ....|| | | ....  
iasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 66-143 8e-09 30.0 In-house 188-271 (288) alignment 
Range on Protein: 66-143
Range on HMM: 188-271/288.0
DYHPPTLEQVVEFMRVMEEAEEKN-EAVSVHCLRGRGRTGTMVACYFI-K-M---QKMSAAEAIAEVRHQRPGSVETVEQENLI
.  |   ....|..| .. |.... . . |||  | ||||| .|   . . .   ...  |...|..|.||.  |.|..|   |
hgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi
subfamily_PTPN13_pd Subfamily PTPN13 67-139 8.4e-09 30.1 In-house 180-257 (273) alignment 
Range on Protein: 67-139
Range on HMM: 180-257/273.0
YHPPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQ
  | . .....|.. . . ....  . |||  | ||.||... . .     . ...   | . ..|.|| | | | .|
gvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdq
PTPlike_phytase Inositol hexakisphosphate 52-110 9e-09 30.1 Pfam-A 88-145 (149) alignment 
Range on Protein: 52-110
Range on HMM: 88-145/149.0
EATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAeEKNEAVSVHCLRGRGRTGTMVACY
. ...|..| | | |   |. |.| .|.|..... ....|. ..|  ||||| |.....
aegfgvkYvRipitdeqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamvia
PTPlike_phytase Inositol hexakisphosphate 52-110 9e-09 30.1 In-house 88-145 (149) alignment 
Range on Protein: 52-110
Range on HMM: 88-145/149.0
EATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAeEKNEAVSVHCLRGRGRTGTMVACY
. ...|..| | | |   |. |.| .|.|..... ....|. ..|  ||||| |.....
aegfgvkYvRipitdeqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamvia
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 29-134 1e-08 28.8 In-house 26-130 (148) alignment 
Range on Protein: 29-134
Range on HMM: 26-130/148.0
MRYLADNGIRYLISLTTECRPPVEATpNVTWVPIGIDDYHPPTLEQVVE-FMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVR
.  |.. |.  ... | |.. ...    . .. . .||     | .. | ..  ...|... . | ||.  |. |   ..  ..|.....|  ||.| |.
lealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvk

HQRPGsV
 .|.. |
skrry.v
subfamily_Slingshot_pd Subfamily Slingshot 30-131 1.6e-08 28.1 In-house 38-138 (169) alignment 
Range on Protein: 30-131
Range on HMM: 38-138/169.0
RYLADNGIRYLISLTTECRPPVEATpnVTWVPIGIDDY-HPPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRH
  | .||..|.. .| |.    . .  .... | . |  .   |..  |  . .|.| .|.  | ||| .|  |. . |  | .|  ..|  ||.. |..
eelkengveyilnvtkeidnffpek..feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvke

QRP
.| 
rrs
subfamily_Ptp69D_pd Subfamily Ptp69D 48-143 2.8e-08 28.2 In-house 175-278 (307) alignment 
Range on Protein: 48-143
Range on HMM: 175-278/307.0
RPPVEATPNVT-WVPIGIDDYH-PPTLEQVVEFMRVMEEAEE-KNEAVSVHCLRGRGRTGTMVACYFI-KM----QKMSAAEAIAEVRHQRPGSVETVEQ
 . ||.. .|. .   | .|.. | . . ...... ..| .. ..  . |||  | ||.|..||   . .     .|..  | . ..|.||.  |.  ||
sgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleq

ENLI
   .
Yvfl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 65-144 2.8e-08 28.2 In-house 173-261 (274) alignment 
Range on Protein: 65-144
Range on HMM: 173-261/274.0
DDYHPPTLEQVVEFMRVMEE----AEEKNEAVSVHCLRGRGRTGTMVACYfIKMQKMSA------AEAIAEVRHQRPGSVETVEQENLIR
|   |   ........ .||    ...|  .| |||  | ||||  .|   | .... .       . ....| .| | |.| || .|| 
dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais.iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelih
subfamily_PTPRA_pd Subfamily PTPRA 74-143 3.7e-08 27.6 In-house 212-287 (330) alignment 
Range on Protein: 74-143
Range on HMM: 212-287/330.0
QVVEFMR-VMEEAEEKNEAVSVHCLRGRGRTGTMVACYFI-KM----QKMSAAEAIAEVRHQRPGSVETVEQENLI
 ...... | .  . . ... |||  | |||||...   . ..    .|.   |.. ..| |||  | | || ..|
GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 65-140 3.8e-08 27.9 In-house 197-279 (298) alignment 
Range on Protein: 65-140
Range on HMM: 197-279/298.0
DDYHPPTLEQVVEFMRVMEEAEEKNE--AVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQE
|   | . . |....| ..  ....   .| |.|  | ||.|| .| . .     | |..   ...  .|..|||.|.| || 
dkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY
Y_phosphatase2 Tyrosine phosphatase family 27-151 5.2e-08 24.9 Pfam-A 23-151 (165) alignment 
Range on Protein: 27-151
Range on HMM: 23-151/165.0
DQMRYLADNGIRYLISLTTECRPPVEAT----PNVTWVPIGIDDYHPPTLEQ----VVEFMRVMeeAEEKNEAVSVHCLRGRGRTGTMVACYFiKMQKMS
    .|    ....|||..| ..  | .     ..  . | |.. . .. |     ... ....   ...|  | .|| ||. |||....|   |.|| |
snfsflksLkLktiislspeeesqdelqfleeekiklyhiaiesnkeelveiksdllkkalkll..lnkenypvllhckrGkhrtglvigclR.klqkWs

AAEAIAEVRHQRPGsVETVEQENLIRDYETFIN
.| ...| |       . . .|..| .... . 
lasilnEyrrFsgs.kkrivdeefienfdsele
subfamily_PTPRB_pd Subfamily PTPRB 57-140 5.3e-08 27.2 In-house 187-274 (293) alignment 
Range on Protein: 57-140
Range on HMM: 187-274/293.0
VTWVPIGIDDYHpptlEQVVEFMRVME---EAEEKNEAVSVHCLRGRGRTGTMVACYFIkMQKMSA------AEAIAEVRHQRPGSVETVEQE
..|.  |. .      .....|.| ..   | ..... . |||  | ||||| .|   . .|...       .  .||.|..|   | |..| 
tsWpdhgvPekt....ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrl.lqaieeedyvdifgivaelReeRnllvqtekqY
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 67-141 8.5e-08 26.7 In-house 151-232 (250) alignment 
Range on Protein: 67-141
Range on HMM: 151-232/250.0
YHPPTLEQVVEFMRVMEEAEEK--NEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQEN
  | . . |.|... ..  ...  |  | |.|  | ||.|. .| . .     | ...   . |  .|..||..||. ||  
gvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 59-144 8.7e-08 26.6 In-house 188-281 (325) alignment 
Range on Protein: 59-144
Range on HMM: 188-281/325.0
WVPIGIDDYhPPTLEQVVEFMRVMEEAEEK----NEAVSVHCLRGRGRTGTMVACYFIKMQKM-----SAAEAIAEVRHQRPGSVETVEQENLIR
|  .| . . | ||  ... .  ..|           . |||  | ||||.... | .  . .        . .  .|..||  ||||.|  || 
wddmGvqkr.patlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliy
subfamily_LRR-DSP_pd Subfamily LRR-DSP 29-147 1e-07 25.3 In-house 138-255 (263) alignment 
Range on Protein: 29-147
Range on HMM: 138-255/263.0
MRYLADNGIRYLISLTTECRPPVEATpnVTWVPI-GIDDYHPPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVR
  .| |.|. ...   ....|    .    .. |  |.|     . |  | . .. |   |.  | |||  |  |. |.| .|..| |..   ||.  | 
ksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeGrkkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvi

HQRPGSVETVEQENLIRDYE
..||         . .. ||
kkrpriqPnpGfkdqlkkye
subfamily_PTPRK_pd Subfamily PTPRK 72-145 1.1e-07 26.0 In-house 192-271 (314) alignment 
Range on Protein: 72-145
Range on HMM: 192-271/314.0
LEQVVEFMRVMEEA-EEKNEAVSVHCLRGRGRTGTMVACY-FIKMQKMSA----AEAIAEVRHQRPGSVETVEQENLIRD
 . .....| ...  ||..  . |||. | ||||| .|.   . | .        .|. ..| ...  ||| || ..| |
atgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiyd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 69-145 2.6e-07 25.0 In-house 191-274 (318) alignment 
Range on Protein: 69-145
Range on HMM: 191-274/318.0
PPTLEQVVEFMRVMEEAE--EKNEAVSVHCLRGRGRTGTMVACYfIKMQKMSAA------EAIAEVRHQRPGSVETVEQENLIRD
|    ......|  ..|.  ...... |||  | ||||. .|   | .... |       . . ..|.||.  | | .| ..| |
pesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd.illerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 69-140 2.8e-07 25.0 In-house 186-265 (281) alignment 
Range on Protein: 69-140
Range on HMM: 186-265/281.0
PPTLEQVVEFMRVMEEAEEKNE--AVSVHCLRGRGRTGTMVACY--FIKM----QKMSAAEAIAEVRHQRPGSVETVEQE
| | ....|| . .....||..  .. .||  | ||||| .|    . ..    ....  . .||.|..|   | || | 
PattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy
subfamily_Tensin_pd Subfamily Tensin 60-125 3e-07 23.1 In-house 73-139 (189) alignment 
Range on Protein: 60-125
Range on HMM: 73-139/189.0
VPIGIDDYHPPTLEQVVEFMRVMEE--AEEKNEAVSVHCLRGRGRTGTMVACYfIKMQKMSAAEAIAE
...|  | . |.||..   .. ...   .. .. | |||  |.||.| .|..| .| .|.||..  | 
ldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsay.mkyskisasadaal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 58-150 3.2e-07 24.6 In-house 184-280 (315) alignment 
Range on Protein: 58-150
Range on HMM: 184-280/315.0
TWVPIGIDDYHPPtleqVVEFMR-VMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQ-----KMSAAEAIAEVRHQRPGSVETVEQENLIRDY--ETF
.|  .|.  |  |    .....| |.   ...  |. |||  | |||||...   .  |      .   ..|  ||..| . |...|| ..| |   |||
swpdmgvpkytip....lmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

I
.
v
subfamily_PTPRD_pd Subfamily PTPRD 69-141 4.7e-07 23.8 In-house 193-271 (564) alignment 
Range on Protein: 69-141
Range on HMM: 193-271/564.0
PPTLEQVVEFMRVMEEA-EEKNEAVSVHCLRGRGRTGTMVACYFIkMQKMSA------AEAIAEVRHQRPGSVETVEQEN
| . .......| .... |.... . |||  | ||||| ..   . .... .       . ....|.||.  |.| ||  
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividam.lerikeektvDiyqyvkalrkqRnamVqteeQYi
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 74-139 4.8e-07 23.5 In-house 203-273 (302) alignment 
Range on Protein: 74-139
Range on HMM: 203-273/302.0
QVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVAC--YFIKMQK---MSAAEAIAEVRHQRPGSVETVEQ
.. . . | .. .. .| . .   .| || |....    . |.||     ..| .. .| ||| .|....|
liktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQ
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 75-144 6.4e-07 23.5 In-house 203-276 (290) alignment 
Range on Protein: 75-144
Range on HMM: 203-276/290.0
VVEFMRVmEEAEEKNEAVSVHCLRGRGRTGTMVACYFiKMQKMSAA------EAIAEVRHQRPGSVETVEQENLIR
|.| |    .  . |... |||  . ||... .| .   ..|.         . . . | |.||||.||.| ..| 
vieemyk.tqrkrgntsivvHCSdtvgrsavfcaaat.tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 82-140 7.4e-07 23.4 In-house 185-248 (267) alignment 
Range on Protein: 82-140
Range on HMM: 185-248/267.0
MEEAEEKNEAVSVHCLRGRGRTGTMVACYF-IKMQKMSAA----EAIAEVRHQRPGSVETVEQE
 .. |. |  . |.|  | ||.||..  .  ..  |        . . ..|.||.| |.| |. 
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkery
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 85-139 1.1e-06 22.3 In-house 217-276 (302) alignment 
Range on Protein: 85-139
Range on HMM: 217-276/302.0
AEEKNEAVSVHCLRGRGRTGTMVAC-YFIKM---QKMS-AAEAIAEVRHQRPGSVETVEQ
 |   ..| |||  | |||||.||  | |..   .|..  .. .  ||. | |.| . .|
cesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_PTPRN_pd Subfamily PTPRN 68-142 1.3e-06 22.4 In-house 202-283 (297) alignment 
Range on Protein: 68-142
Range on HMM: 202-283/297.0
HPPTLEQVVEFMRVMEEA-EEKNEAVSVHCLRGRGRTGTMVACYFI--KMQ----KMSAAEAIAEVRHQRPGSVETVEQENL
 |..   ..|| | .. .   .  .. |||  | ||||. ..  ..  ...    ..  | ..  .| |||| |.| .| ..
vPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef
subfamily_PTPN6_pd Subfamily PTPN6 74-143 1.3e-06 22.6 In-house 207-289 (306) alignment 
Range on Protein: 74-143
Range on HMM: 207-289/306.0
QVVEFMRVMEEAEE-----KNEAVSVHCLRGRGRTGTMVACYFI----KMQK----MSAAEAIAEVRHQRPGSVETVEQENLI
.|..|.. ... .|     .. .. |||  | |||||..    .    . ..    .   ...  ||.|| | | | .| ...
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 69-115 1.5e-06 21.9 In-house 190-238 (439) alignment 
Range on Protein: 69-115
Range on HMM: 190-238/439.0
PPTLEQVVEFMRVMEEAEEKNEA--VSVHCLRGRGRTGTMVACYFIKMQ
|     |..|.| .. |..|.|   | |||  | |||||..|      |
paqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 79-145 1.9e-06 22.3 In-house 204-277 (305) alignment 
Range on Protein: 79-145
Range on HMM: 204-277/305.0
M-RVMEEA-EEKNEAVSVHCLRGRGRTGTMVACYfIKMQKMSA------AEAIAEVRHQRPGSVETVEQENLIRD
. ||...  ..|. .. |||  | ||||. .|   | .... .      .| . ..|..|.. |.| .| . . |
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavd.ialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 58-141 2e-06 22.5 In-house 158-245 (284) alignment 
Range on Protein: 58-141
Range on HMM: 158-245/284.0
TWVPIGIDDYHPPtLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFI--KMQKM---SAAEAIAEVRHQRPGSVETVEQEN
 |   |  ||  . | ..|. .| ... |.... . |||  | ||||....   .  .|..       . . ..| ||.  |. . |  
gwpdvgvpdypsd.lmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 72-132 2.1e-06 20.9 In-house 62-123 (145) alignment 
Range on Protein: 72-132
Range on HMM: 62-123/145.0
LEQVV-EFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPG
| |   |    ..   |.   | |||. |  |. |.   ...|  .|. .||  .|| .|  
lsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 58-140 2.3e-06 22.2 In-house 194-280 (319) alignment 
Range on Protein: 58-140
Range on HMM: 194-280/319.0
TWVPIGIDDYHPPtLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFI--KMQKM---SAAEAIAEVRHQRPGSVETVEQE
 |   |  ||  . | ..|. .| ... |.... . |||  | ||||. ..   .  .|..       . . ..| ||.  |. . | 
GwpdvGvpdypsd.lmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 80-139 2.5e-06 21.7 In-house 200-265 (307) alignment 
Range on Protein: 80-139
Range on HMM: 200-265/307.0
RVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKmQKM-------SAAEAIAEVRHQRPGSVETVEQ
 ..|  . ... | |||  | ||.||.||  ... .||       .  . . |.| ||. ...|  |
nlleavrydtnpvvvhcsaGvGrsGtivaislvq.dkmiaGinckdmkklveelrsqrhyaiqteaq
TatD_DNase TatD related DNase 55-139 4.5e-06 12.3 Pfam-A 86-166 (255) alignment 
Range on Protein: 55-139
Range on HMM: 86-166/255.0
PNVTWV-PIGIDDY-H--PPTLEQVVEFMRVMEEAEEKNEAVSVHCLRgrgrtgTMVacYFIKMQKMSAAE-AiAEVRHQRPGSVETVEQ
..|  .  ||.| | .   .  .|   | . .| |.| . ....|. .      .     .... |  |.. | . | |   ||.|....
skvvaiGEiGLDyysreestkeaqeevFeeqlelAkelklplviHtre......aee..dlleilkeeaeaka.kvvlHsfsgseeeake
subfamily_PTPN14_pd Subfamily PTPN14 79-143 4.8e-06 20.8 In-house 219-288 (300) alignment 
Range on Protein: 79-143
Range on HMM: 219-288/300.0
MRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLI
.  . |..|..  | |||. | |||| ..   ..     . ...   ...| .|.||   |.|. | . .
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv
DSPn Dual specificity protein phosphatase, N-terminal half 65-131 5.1e-06 17.3 Pfam-A 39-112 (141) alignment 
Range on Protein: 65-131
Range on HMM: 39-112/141.0
DDYHPPTLEQVVEFMRVMEE----AEEKNEAVSVHCL---RGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRP
 |. |  | |...|.. ...    ||.|.... . .    . | .. .....| . ..|.|. ||....... |
adFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspeealkplesvep
subfamily_CG42327_pd Subfamily CG42327 86-143 5.9e-06 20.2 In-house 244-307 (319) alignment 
Range on Protein: 86-143
Range on HMM: 244-307/319.0
EEKNEAVSVHCLRGRGRTGTMVACYfIKMQKMSAA-------EAIAEVRHQRPGSVETVEQENLI
.|..  . |||  | ||||...|   |.....  .       . .  ||..|  .| |.|| ..|
resqGPlvvhcsdGvGrtGlviasd.iairsleeskrsvdiPqlvssvrrdrasavltkeqyefi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 70-144 6.5e-06 20.2 In-house 179-259 (283) alignment 
Range on Protein: 70-144
Range on HMM: 179-259/283.0
PTLEQVVEFMRVME-EAEEKNEAVSVHCLRGRGRTGTMVACY--FIKMQKMSA---AEAIAEVRHQRPGSVETVEQENLIR
. .. .| | .|.    |.|.  . |||  | |||....|      ...  |     . .  .| ||.. | | .|  |. 
aiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 82-145 7e-06 20.1 In-house 221-289 (297) alignment 
Range on Protein: 82-145
Range on HMM: 221-289/297.0
MEEAEEKNEAVSVHCLRGRGRTGTMVACYFIK--M--QKMS-AAEAIAEVRHQRPGSVETVEQENLIRD
.. .  .|  . |||  | ||.| .| .  |   .  ...  .|  .  .|.||.  |.|.|| .|. |
lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd
subfamily_STYXL1_pd Subfamily STYXL1 42-130 7.2e-06 19.3 In-house 43-133 (157) alignment 
Range on Protein: 42-130
Range on HMM: 43-133/157.0
SLTTECRPPVEATPN-VTWVPIGIDDYH-PPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQR
 ..... . ...... .  . | ..|      ||.. | .. .|. ....|.| |   .|  |. .....|..  .|..  .| . ... .
nvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 74-143 9e-06 20.0 In-house 200-276 (297) alignment 
Range on Protein: 74-143
Range on HMM: 200-276/297.0
QVVEFMRVMEEA-EEKNE-AVSVHCLRGRGRTGTMVACYFI-----KMQKMSAAEAIAEVRHQRPGSVETVEQENLI
......  ...  ....|  . |||| | |||| ...   .     . ...   . .  .|..||  | | || ...
sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv
subfamily_PTPN3_pd Subfamily PTPN3 69-142 9.6e-06 19.7 In-house 187-266 (280) alignment 
Range on Protein: 69-142
Range on HMM: 187-266/280.0
PPTLEQVVEFMRVMEEAE-EKNEAVSVHCLRGRGRTGTMVA-----CYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENL
|   ....||.. ....   |.| | |||  | |||| ...     .   . ...   . . ..| ||   |.|..| ..
PddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykf