Gene MTMR9 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR9
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP038_AA protein Get Run
SpurP038_AA_122-503 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR9_pd Subfamily MTMR9 110-499 5.9e-201 659.6 In-house 1-392 (393) alignment 
Range on Protein: 110-499
Range on HMM: 1-392/393.0
PFFYRSTFDELEDGWHAFLPENEFARL--ASDDWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLTGT
||||||....||||..|| .|||||.|  |||.||||.|||||.||.|||..|||||.|||..|..|||||.|||||.|||.|...|.|.|||||||.|.
pffyrsvatiledgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgs

NTKRCKDDERLLNAALSVGKRGYIIDTRSMNGAMAARTKGGGFETEVNYPQWRRVNKPLDKPSILQESLCKLLEACMDTGCSADKWISRLTNCGWLHHVK
..||||.||.|||..|...|.|.|.||||.. |..||.||||.||||.|.||......|......|.||.||||||.|.|.|.||..|||...|||..|.
sgkrckedekllnlvlkklkkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqva

ETLTTACLVAQCVDRENSAVLVHGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKSVFSQNKNKYAGPVYLLFLDCVWQIFQ
..|..|. ||||.|.|...|.|||.|||||.||||||||.|||.|.||||||||||||||||||||| ||.||......|.|..|||.|||||||.||..
dlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqils

QFPCSFEFSEKFLIMLFENAYASRFGTFLCNNENERKMARVSEKTVSLWTYVNRPQILQTFFNPLYQPNQQVIWPSVAPQSLALWSSLYMRW
|||.||||.|..||.|||..|.|.||||||.||.|||......||||||.|||||. |..|.||||..|..|||||||||||.|||.||.||
qfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyeanaeviwpsvapqslelWselylrw
0040695 (Phosphotyrosine protein) phosphatases II 121-500 2.7e-129 425.1 In-house 5-386 (388) alignment 
Range on Protein: 121-500
Range on HMM: 5-386/388.0
EDGWHAFLPENEFARLAS--DDWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLTGTNTKRCKDDERL
|.||. . ...|. ||    | ||||.||.|...|||||. ..|||||.|..|...| || .||.|.|||.|   . |.|||||||.|....|...||.|
eegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledekl

LNAALS---VGKRGYIIDTRSMNGAMAARTKGGGFETEVNYPQWRRVNKPLDKPSILQESLCKLLEACmDTGCSADKWISRLTNCGWLHHVKETLTTACL
|.| |.     ....|.|.|..  |.|.|..|||.| | .||... . ..... . ..||| |||.|| .  .. ....|.| ..|||...| .| .|.|
leailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdslnllslleesgwldliklilelavl

VAQCVDRENSAVLVHGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKsVFSQNKNKYAGPVYLLFLDCVWQIFQQFPCSFEF
.....|..|| ||||.|.| |   |..||||..||...||..||  |||.||...||.|..|..  . |....|   ||.|||||||||. .|||..|||
ivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh.leseidskefsPvFllFLdcvwqLlrqfPtaFeF

SEKFLIMLFENAYASRFGTFLCNNENERKMARVSEKTVSLWTYVNRPQILqtFFNPLYQPNQQ-VIWPSVAPQSLALWSSLYMRWT
.| .|. |.. .|..||||||.|.| || ...|||.|.|||.|.....    |.||||.|..  |..||. ...| ||...|.||.
nerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkse..flnplYdpsslevllpslsvldlllWleyylrwl
Myotub-related Myotubularin-like phosphatase domain 108-444 6e-128 419.5 Pfam-A 2-351 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 108-444 6e-128 419.5 In-house 2-351 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 121-500 7.2e-114 373.1 In-house 4-387 (389) alignment 
Range on Protein: 121-500
Range on HMM: 4-387/389.0
EDGWHAFLPENEFAR--LASD-DWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLTGTNTKRCKDDER
||||. . ||.|. |  | ..  |||. .||....|..||. ..|||...|..| ..||||  ||.|.||...  ...||||.||||.|.. ||.|.||.
edGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedek

LLNAALSVGKRG---YIIDTRSMNGAMAARTKGGGFETEVNYPQWRRVNKPLDKPSILQESLCKLLEACMDtGCSADKWISRLTNCGWLHHVKETLTTAC
.|.|.|.  ..    .|.| ||.  |.| ..||.| |.| .| . . .   ...  ...||| || |...    . .||.| | .  ||.|.|  |..| 
ylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlp.nvddkkwlsalestkWlehiklilagav

LVAQCVDRENSAVLVHGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKSVfSQNKNKYAGPVYLLFLDCVWQIFQQFPCSFE
 ....|..|.. |||| |.| |   |.||||...||.  ||..||| |||.||.. ||.| .| ...  ......  .||.| |.|||||. .|||. ||
kivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgd.knssdaersPvFlqfiDcvwqltrqfptAFe

FSEKFLIMLFENAYASRFGTFLCNNENERKMARVSEKTVSLWTYVNRPqiLQTFFNPLYQPN--QQVIWPSVAPQSLALWSSLYMRWT
| |.|||.| .. |...|||||.|.|.||. ..|.|||||||.|||     ..|.||||...  ..|. | .. ..| ||.. |.|| 
fneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnss..keeftnplyaeelekkvlypkaslrrlelWkeyylrwn
subfamily_MTMR6_pd Subfamily MTMR6 110-499 3e-110 361.2 In-house 3-395 (397) alignment 
Range on Protein: 110-499
Range on HMM: 3-395/397.0
PFFYRSTF--DELEDGWHAFLPENEFARL--ASDDWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLT
 | |...   .| ..||. .  ..|..|.  ... | .. .||....| .||  . ||||.. ..|| |. ||  ||.|.|||.| .... | |.||||.
afsykpkkdkeekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqpls

GTNTkRCKDDERLLNAAL---SVGKRGYIIDTRSMNGAMAARTKGGGFETEVNYPQWRRVNKPLDKPSILQESLCKLLEACMDTGCSADKWISRLTNCGW
| .. ||..||.||.|     .  .  |..|||    |.| ...| |.|.| ||   .     ..   ...||| ||||..     |  ...| | ..||
gfsa.rcledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgw

LHHVKETLTTACLVAQCVDRENSAVLVHGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKSvfsQNKNKYAGPVYLLFLDCV
|.|.|  | .....|. | .|. .|||| |.| | . ||.|||...||   ||..||  |||.||.  || | .|| .    ....|   |... ||.||
lkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll...dedskevsPiftqflecv

WQIFQQFPCSFEFSEKFLIMLFENAYASRFGTFLCNNENERKMARVSEKTVSLWTYVNRPQilQTFFNPLYQPNQQ--VIWPSVAPQSLALWSSLYMRW
||. .|||..|||.|.||. | .  |...|||||.|.|..|. ....|.| |||.|. . .  . . ||||.....  |..|..||..| ||..||.|.
wqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerk..ddylnplykaetekevlkpdtapaalklwralynrf
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 109-500 3.9e-107 350.9 In-house 1-403 (404) alignment 
Range on Protein: 109-500
Range on HMM: 1-403/404.0
YPFFYRSTFDELEDGWHAFLPENEFARL--ASD-DWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLT
. | |. .. .|||||  . .|.|..||   |. .|||| .|.....|..||  ..||.|| |. |...|.||  ||.|.||. |  ....| |||||| 
fafsysekksvledgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplv

GTNTKRCKDDERLLNAALS---VGKRGYIIDTRSMNGAMAARTKGGGFETEVNYPQWRRVNKPLDKPSILQESLCKLLEACMDTGCSADKWISRLTNCGW
| . .|...||.|.|.  .    ..  ||.|.|..  |.| ..|| |.|.  .| .     . ...   |.||| || .|. ..  . ..|.|.| . .|
GltksrseedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrW

LHHVKETLTTACLVAQCVDRENSAVLVHGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKsvFSQNKNKYAGPVYLLFLDCV
| |.|. |...  ... .. |.| |||| |.|.|.  |..||.|..||.  ||..||. |||.||.. || | .|...   ......   |..| |.|||
ldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq..ttekssdersPiflqFidcv

WQIFQQFPCSFEFSEKFLIMLFENAYASRFGTFLCNNENERKMARVSEKTVSLWTYVNRPQilQTFFNPLY----QPNQQVIWPSV-----APQSLALWS
.|. .||| ||||.||||| . .. |..||||||...|.||. ... ..|||||....  .  ....||||    . ... |  |       .. . |||
yqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleank..seylnplyilekkeqkenitssessssadikliklWs

SLYMRWT
..|.|| 
eyylrwr
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 139-499 1.5e-71 233.3 In-house 40-404 (405) alignment 
Range on Protein: 139-499
Range on HMM: 40-404/405.0
DDWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLTGTNTKRCKDDERLL-NAALSV-GKRGYIIDTRS
  |... .||....| ||. ...| .   |  | .  .||  || | ||.   . .. | | |||| | .  || .||    . |||   |  |.||.| 
cywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslalsapsktlylidarp

MNGAMAARTKGGGFETEVNYPQWRRVNKPLDKPSILQESLCKLLEACMD------TGCSAD-KWISRLTNCGWLHHVKETLTTACLVAQCVDRENSaVLV
   |.|  ..| |||   |||. . |   . .  ... || ||  |            |.| ..   . . ||. |.|  | .| . |. . . || .||
klnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaelilkgns.ilv

HGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKsvFSQNKNKyAGPVYLLFLDCVWQIFQQFPCSFEFSEKFLIMLFENAYA
| |.| | . |.|||.|..||   ||. ||. |||.||.  || |  |  .  .  |...   |..  ||||..|. .|||  |||.  .|... .| ..
hcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlgh..lpgneee.rspifqqfldccfqllsqfpllfeftpslllfisdnihs

SRFGTFLCNNENERKMARVSEKTVSLWTYVNRpqILQTFFNPLYQPNQ-QVIWPSVAPQSLALWSSLYMRW
 ..|||| | |..|   .|  ||.|.|. ||    .. |.|| |.|.. | | | .  . | || . ||| 
ckygtflnncekdrvqdqvktktisiwsevnl..nvnkflnpyynpqdiqsikpklysrclelwkacymrv
subfamily_MTMR3_pd Subfamily MTMR3 230-497 1.9e-71 234.1 In-house 176-440 (442) alignment 
Range on Protein: 230-497
Range on HMM: 176-440/442.0
YIIDTRSMNGAMAARTKGGGFETEVNYPQWRRVNKPLDKPSILQESLCKLLEACMdTGCSADKWISRLTNCGWLHHVKETLTTACLVAQCVDRENSAVLV
 |.| ||   |.| |.||||.|.|  ||.   | . |     ...|. .| . .  ..    .|.|.| .  ||... . |..|  |.. ||.|. .|||
livdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlv

HGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKSVFSQNKNKyAGPVYLLFLDCVWQIFQQFPCSFEFSEKFLIMLFENAYA
| |.| |   |...||...||   ||..||..|.||||.. || |  ||.    ....|    ||.| .||.| |. .|||.||||.| ||. | . .|.
hCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddane.rcPvflqwldavhqlqrqfPtsfefneaflvklvqhtys

SRFGTFLCNNENERKMARVSEKTVSLWTYVNRPQilQTFFNPLYQP-NQQVIWPSVAPQSLALWSSLYM
. |||||.|.|.||.  .| |.|.|.|....  .  ... | ||.. ...|..|.|  ..| ||| .|.
clfGtflansekereeekvkertlsvWsllrake..keyrnllykekteavllpavsvrelklwsevyl
subfamily_MTMR10_pd Subfamily MTMR10 135-499 2.1e-59 193.2 In-house 20-377 (380) alignment 
Range on Protein: 135-499
Range on HMM: 20-377/380.0
RLASDDWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQpltGTNTKRCKDDERLLNAALSVGKRGYiidt
. .|| .. . .|. |......|. ..||.|..|. . .       .|||.... |.  ..... | .   ... .  |..|.  .  .  .. .     
ktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsal...qeaesadkekeekmlelvrkchpan....

rsmngamaartkgggfetevnYPQWRRVNKPLDKPSILQESLCKLLEACMDTGCS-----ADKWISRLTNCGWLHHVKETLTTACLVAQCVDRENSAVLV
                       . . ... |.  . .|..  || | |.   .       |||.| | . .||. |.  | ||  ....| ...  |..
.....................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvil

HGSEGLDASLQVTSLAQVILDADCRTVRGFEALIEREWIQAGHPFLSRCSKSVFSQNKNKyagPVYLLFLDCVWQIFQQFPCSFEFSEKFLIMLFENAYA
  ||| | |. | ||||..||  .|| .||. ||..||. ||||||.|. . . |.....   ||.|||||||.|  .||| .|||.|.|||.|.   ..
qesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpsekses...pvfllFldcvdqlleqfpseFeFtetfLialwdsshs

SRFGTFLCNNENERKMARVSEKTVSLWTYVNRPQILQ----TFFNPLYQPN----Q-----------QVIWPSVAPQSLALWSSLYMRW
. |.|||.|.|..|. | || . . .  .  . . |.     . ..||.      .           ..| |      . ||.  |.||
gifltflfnseeqrlkavvsssplliakselkendllkdeldyrqglyaeiiksirrlaaaksylrseiirPllqipdiqlWdeCYlRW
subfamily_MTMR5_pd Subfamily MTMR5 270-493 1.9e-48 157.5 In-house 239-476 (483) alignment 
Range on Protein: 270-493
Range on HMM: 239-476/483.0
SILQESLCKLLEACMDTGCSADK----WISRLTNCGWLHHVKETLTTACLVAQCVDRENSAVLVHGSEGLDASLQVTSLAQVILDADCRTVRGFEALIER
. .. |. ||| ||.    ....    ... . .  ||. ... |  .  |.. .| ..|.|||   .| |.  ||.||||..||.  ||. ||..|.|.
rqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveK

EWIQAGHPFLSRCSKSVFSQNKnkYAGPVYLLFLDCVWQIFQQFPCSFEFSEKFLIMLFENAYASRFGTFLCNNENERKMARV----------SEKTVSL
||.  || |  |...   .|.      ||.| |||||.|. .||| .|||.. .| .|     . || ||| . |.||  . .           . ..|.
EWLafGHrFtkrsnqtlsaqss..gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksv

WTYVNRPQ-ILQTFFNPLYQP-NQQVIWPSVAPQSLALWS
| |..| .     |.| ||.| ...|. ||.   || .|.
wdyidrqhkrspifynflyspdesevlrPssnvsslkvWd
subfamily_MTMR3_pd Subfamily MTMR3 130-223 1.2e-26 86.4 In-house 30-126 (442) alignment 
Range on Protein: 130-223
Range on HMM: 30-126/442.0
ENEFARLA---SDDWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLTGTNTKRCKDDERLLNAAL
..|..||    .. |||| ||..|..|.|||  .||||||.||.| ..| ||  .|.| . . |. ...|. |.|||  |  . |...||.||.|. 
keeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaia
subfamily_pats1_pd Subfamily pats1 388-477 7.4e-24 76.1 In-house 549-636 (691) alignment 
Range on Protein: 388-477
Range on HMM: 549-636/691.0
NKYAGPVYLLFLDCVWQIFQQFPCSFEFSEKFLIMLFENAYASRFGTFLCNNENERKMARVSEKTVSLWTYVNRPQilQTFFNPLYQPNQ
|.   |... ||| |||....||  ||| | .|..| .....||||.||...  ..   .| ... |.|...|. .   .| | ||..  
nrsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnk..srfinllykhsa
subfamily_pats1_pd Subfamily pats1 272-383 3e-19 60.9 In-house 349-462 (691) alignment 
Range on Protein: 272-383
Range on HMM: 349-462/691.0
LQESLCKLLEACMDTGCSADKWISrLTNCGWLHHVKETLTTACLVAQCVDRENSAVLVHGSEGLDASLQV---TSLAQVILDADCRTVRGFEALIEREWI
..|   .||.. .. . | |.| . . .  |.  ||  | .|  |.. .|. .| .|   ... .  |..   .|||||..|   ||. ||  |||.||.
veerffdllqsilsldgsddewke.ieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewl

QAGHPFLSRCSKSVF
. |.||  ..     
syGfPfskinyhkes
subfamily_MTMR5_pd Subfamily MTMR5 137-203 2.8e-17 54.7 In-house 27-93 (483) alignment 
Range on Protein: 137-203
Range on HMM: 27-93/483.0
ASDDWRISYVNKNFQVCPSYPPAVIVPKSIDDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQP
.....||| |||...|| |||  ..||....||.. . |     .|.|.  ..|. .|....||...
krgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_pats1_pd Subfamily pats1 127-201 1.9e-10 31.8 In-house 11-84 (691) alignment 
Range on Protein: 127-201
Range on HMM: 11-84/691.0
FLPENEFARLASD-DWRISYVNkNFQVCPSYPPAVIVPKSIDDDtLVQSAAFRYGGRFPILSYMHTAQKTVILRSS
 | | .  .|  | |||.  .  . ...  ||. ..|||.. |. |..| . .   ..|.||. . ..|....|  
lliegqrlkldldkdwrvvefl.srdlseiyPkrilvPklvsde.llvsyvrkrsskiPvlswsnqnnksslfric