Gene PTPRB-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP067_AA protein Get Run
SpurP067_AA_1073-1324 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 1064-1263 6.1e-89 292.9 In-house 24-225 (293) alignment 
Range on Protein: 1064-1263
Range on HMM: 24-225/293.0
NMKDVELTRAIRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVV
... .|    ...||.......| ...|  ||||||||||| .||||....||.||||||.|||||..||||.||.|||||.|.||.|||.||......|
dlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiiv

MVTQLVEKGKVKCDQYWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTK--PPSSAPVAV
|.|||||||||||..|||.|. |||||||.||.... | .|| |.|.... ....| ||...|.|||||||||....||.|.|..|...    |..|. |
mltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HC
||
hC
subfamily_PTPRD_pd Subfamily PTPRD 1078-1263 2.3e-79 262.5 In-house 35-221 (564) alignment 
Range on Protein: 1078-1263
Range on HMM: 35-221/564.0
GRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCD
|...|...|  |||  |||| ||..||..||.||.|. .||||||| ..| |......||| ||||. |..| |||.||||..|.||.|.|.|||||||.
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

QYWPDDHmPVLYGDIQVTMNQTFEENDWNIKEFAV--QLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
.|||... .  ||...||.... | .|  |..| .  . ... | ||...| |||||||||| ..||..||..|....| . |. |||
kYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC
0051299 (Phosphotyrosine protein) phosphatases II 1074-1263 5.1e-70 231.5 In-house 32-226 (288) alignment 
Range on Protein: 1074-1263
Range on HMM: 32-226/288.0
IRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGK
....  ..|...|. |.|. ||||..|||||..|||||..|..||||||| .||.|. ..|..||.|||||.|..| |||.|||||...||.|.|||.|.
llsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgr

VKCDQYWPDdHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ------LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
.||.||||. . .. ||||.||.  . ...|. . .. |.        .. |.|.|. ...|||||||.| ..||.|.|..|.  .... ||.|||
ekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHC
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1074-1263 6e-69 227.5 In-house 29-220 (318) alignment 
Range on Protein: 1074-1263
Range on HMM: 29-220/318.0
IRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGK
. .. ...|.  ...|.|  ||||.|||.||.|||||.....||||||||.|||.|... ..|||.|.||| | .|.|||.|||| ...||.||..|.||
lsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergk

VKCDQYWPDDHmPVLYGDIQVTMNQTFEENDWNIKEFAVQLR--DQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTK-PPSSAPVAVHC
.|...|||..  .  ||...|......| .|. ..|| |. .  .. | || ... ||||.|||||.  ||...|...... ...  |..|||
akvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC
0050432 (Phosphotyrosine protein) phosphatases II 1074-1263 7.8e-68 224.4 In-house 51-239 (308) alignment 
Range on Protein: 1074-1263
Range on HMM: 51-239/308.0
IRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLspvddEEGSDYINSNYIPGF--TSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEK
...|   .....|  |.|. ||||..|||||..||||     .||||||| .|..|.   .||..||.|||||.|..| |||.|||||...||.|.|||.
llsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklven

GKVKCDQYWPDD--HMPVLYGDIQVTMNQTFEENDWNIKEFAVQL--RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKppSSAPVAVHC
|..||.||||..  . .. ||...||.  . ...|. . .. ..    .. |.|.|. ...|||||||.| ..||.|....|..   .. |..|||
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHC
0046845 (Phosphotyrosine protein) phosphatases II 1080-1263 2.8e-67 222.4 In-house 17-211 (284) alignment 
Range on Protein: 1080-1263
Range on HMM: 17-211/284.0
KMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDE-EGSDYINSNYIPGF-----TSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGK
 .....|. |.|. ||||..|||||..||||...|.. |.||||| .|..|.      .....||.|||||.|..| |||.|||||...||.|.|||.|.
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

VKCDQYWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQL---RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKP--PSSAPVAVHC
.||.||||... .. |||..||.  . ...|. . .. ..     .. |.|.|. ..||||||||.|.. ||.|.| .|.  .  |.. |..|||
ekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC
0040438 (Phosphotyrosine protein) phosphatases II 1082-1263 5.1e-67 221.7 In-house 34-216 (317) alignment 
Range on Protein: 1082-1263
Range on HMM: 34-216/317.0
TTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWP
|...|  |.| .||||..|||||..||||||..  ..||||| .|..|.  .|..||.|||||.|..| |||.|||.||..||.|.|.|.|..||.||||
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwp

DdHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ--LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
.   .. |||..||. ...|...... .. |.    .. |.|.|. ...|||||||.| . ||.|....|.  .... ||.|||
l.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHC
0045450 (Phosphotyrosine protein) phosphatases II 1080-1263 1.2e-65 217.6 In-house 44-241 (307) alignment 
Range on Protein: 1080-1263
Range on HMM: 44-241/307.0
KMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDE-EGSDYINSNYI--------PGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVE
 .....| .|.|  ||||..|||||.||||||..|.. |.||||| .|.        .|. ..|..||.|||||.| .| |||.|||.||..||.|.|||
lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

KGKVKCDQYWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ---LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRS--TKPPSSAPVAVHC
.|..||.|||||.  .. ||...||.  . ..... .  . |.     .. |.|.|. ...|||||||.| . ||.||...|.   . |.. ||.|||
lgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC
0036941 (Phosphotyrosine protein) phosphatases II 1074-1263 1.2e-64 213.9 In-house 22-214 (297) alignment 
Range on Protein: 1074-1263
Range on HMM: 22-214/297.0
IRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLspvdDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGK
. ..   .....| .|.|. ||||..|||||.|||||    |.||||||| .|..|.  .|..||.|||||.|..| |||.||||||..||.|.|||.|.
llpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

VKCDQYWPDD-HMPVLYGDIQVTMNQTFE--ENDWNIKEFAVQL--RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRS--TKPPSSAPVAVHC
.||.||||..   .. |||..||.  . .  ..|. . .. |.    .. |.|.|. ...||||||||| . ||.||...|.   . ||. || |||
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHC
0047943 (Phosphotyrosine protein) phosphatases II 1077-1263 1.6e-64 213.3 In-house 24-212 (273) alignment 
Range on Protein: 1077-1263
Range on HMM: 24-212/273.0
VGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLspvdDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKC
.   .|...|. |.|  ||||..|||||..||||    ...|||||| .|..|. ..|..||.|||||.|..| |||.|||||...||.|.|||.|..||
lkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekc

DQYWPDDHM--PVLYGDIQVTMNQTFEENDWNIKEFAVQL--RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPP--SSAPVAVHC
.||||..    .. ||...||.  .....|. . .. ..    .. |.|.|. ...|||||||.| . || ||. .|..     |. ||.|||
aqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC
0039614 (Phosphotyrosine protein) phosphatases II 1083-1263 1.7e-64 213.5 In-house 48-229 (297) alignment 
Range on Protein: 1083-1263
Range on HMM: 48-229/297.0
TNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDE-EGSDYINSNYIPGFTS-PREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKvKCDQYW
. .| .|.|. ||||..|||||..||||.|.|.  ..||||| .|..|.   .|..||.|||||.|..| |||.|||.||..||.|.|||.|. ||.|||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqyw

PDDHMpvLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKP--PSSAPVAVHC
|..     |||..||. .......... .. |.  .. |.|.|. ...|||||||.|.. || |.. .|.     |.. ||.|||
peegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHC
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1073-1263 3.3e-64 211.7 In-house 23-215 (281) alignment 
Range on Protein: 1073-1263
Range on HMM: 23-215/281.0
AIRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKG
.....|.. |.. . ...|| ||||.||  || ||||..| .... .||||.|..||.....||||.|||.| . ...|.|.|||.|...||||. .|.|
klaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieag

KVKCDQYWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAV-QLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRI-RSTKPPSSAPVAVHC
|.|| .|||||.  . |||..|..... |.. .  ..| . .   . | |.. ....|||||||.....|| | . . . |.. . ||. .||
klkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1074-1263 1.7e-63 209.4 In-house 30-219 (288) alignment 
Range on Protein: 1074-1263
Range on HMM: 30-219/288.0
IRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGK
. ..... .....  . |  |||| |||||| .||||  ...|.|.||||..|| |  . ..||| ||||. | .| |....|....|.||.|.|||.||
LaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggk

VKCDQYWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
 ||..||||.. |..||...||. .. |..|.  ... .. . ... . ....|.|||||||||.. ||...| .  ...  . |. |||
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhC
0043336 (Phosphotyrosine protein) phosphatases II 1081-1263 1.8e-63 210.0 In-house 35-217 (278) alignment 
Range on Protein: 1081-1263
Range on HMM: 35-217/278.0
MTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYW
.|...| .|.|. ||||..|||||..|||||... ...||||| .|..|.  ||..||.|||||.|..| |||.||..|||.||.|.|||.|.|||.|||
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

PddHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ--LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
|    .. |||..||.  . ...|. .  . |     .. |.|.|. .|.||||||||| . || |....|.  ..|. ||.|||
p..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHC
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1078-1263 1.8e-61 202.9 In-house 35-223 (319) alignment 
Range on Protein: 1078-1263
Range on HMM: 35-223/319.0
GRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCD
. ..|...|  . |  ||||.|||.||||||.||..|. |||||||...| |.   ...|| |.||  |..|.|||.||... .|||.|.||||.|||. 
avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklk

QYWPDDHmPVLYGDIQVTMNQTFEENDWNIKEFAVQLRD-QR--RYVRHWNFLSWPDHGVPESSQALLAFIRRIRS-TKPPSSAPVAVHC
.|||. . .. || . ||...  | .|. |... .. .  .   | | |. ...||||.|||....||....|||  .. ..| |. |||
kywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhC
0040439 (Phosphotyrosine protein) phosphatases II 1083-1263 8.3e-61 201.0 In-house 3-186 (249) alignment 
Range on Protein: 1083-1263
Range on HMM: 3-186/249.0
TNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPD
...|  |.|. ||||..|||||..|||||.... ..||||| .||.|. ..|..||.|||||.|..| |||.||...|..||.|.|||.|..||.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

dHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ--LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRS--TKPPSSAPVAVHC
   .. |||..||. .. ...|. . .. ..    .. |.|.|.....|||||||.| . ||.||...|.  .. |.. ||.|||
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHC
DSPc_SM00195 1079-1263 2.4e-60 199.4 In-house 14-202 (263) alignment 
Range on Protein: 1079-1263
Range on HMM: 14-202/263.0
RKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQ
 . .|..|  ..|. ||||.||||||.|||||.. ...||||||| ||| | .....|||.||||| | .| |||.||..|...||.|. .|.|| |||.
spketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPDD-HMPVLYGDIQVTMNQTFEEN-DWNIKEFAVQLRD--QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
|||.. . .  .|.|.|.. .. ... ....... ..  .  . | |..... .|||||||.| . .|...| ....|  ||.|. |||
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC
PTPc_SM00194 1079-1263 2.4e-60 199.4 In-house 14-202 (263) alignment 
Range on Protein: 1079-1263
Range on HMM: 14-202/263.0
RKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQ
 . .|..|  ..|. ||||.||||||.|||||.. ...||||||| ||| | .....|||.||||| | .| |||.||..|...||.|. .|.|| |||.
spketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPDD-HMPVLYGDIQVTMNQTFEEN-DWNIKEFAVQLRD--QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
|||.. . .  .|.|.|.. .. ... ....... ..  .  . | |..... .|||||||.| . .|...| ....|  ||.|. |||
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC
subfamily_PTPN12_pd Subfamily PTPN12 1075-1263 6.7e-60 197.4 In-house 24-214 (290) alignment 
Range on Protein: 1075-1263
Range on HMM: 24-214/290.0
RKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKV
 |  ....|... .. || |||| .||||| .||.||  ..||||||||.|.| | ... |||| ||||| | || ||||||.||. |||. ..|| || 
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCDQYWPDD-HMPVLYGDIQVTMNQ-TFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
||..|||.  .... .|...||...    ..|. |. ..|. ....| |. ... .|||||||.| . ||..|. .|...  ..||..|||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC
subfamily_PTPN9_pd Subfamily PTPN9 1073-1252 1.4e-59 196.6 In-house 24-206 (297) alignment 
Range on Protein: 1073-1252
Range on HMM: 24-206/297.0
AIRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKG
.||.   . | ... ..||. |||||..| ||.|||.|. ||..| |||||.|.. |.  .. .|| ||||. |..| |||.|||.| ..||.|..||.|
eirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvverg

KVKCDQYWP-DDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ--LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTK
..|| |||| ...    .||..|.  .. ||.|.... . ..    .. | | |. ||||||.|||.|...|| ... .|...
rlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq
0042113 (Phosphotyrosine protein) phosphatases II 1084-1263 1.5e-59 196.7 In-house 2-183 (245) alignment 
Range on Protein: 1084-1263
Range on HMM: 2-183/245.0
NTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDd
..|  |.|. ||||..|||||.|||||||.. ...||||| .|..|.  .. .||.|||||.|..| |||.||...||.||.|...|.|.|||.||||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

HMPVLYGDIQVTMNQTFEENDWNIKEFAVQ--LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKP-PSSAPVAVHC
. .. |||..||.  .  ..|. . .. |.    |. | |.|. .|.|||||||.... || |....|.    .|. ||.|||
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHC
subfamily_PTPRK_pd Subfamily PTPRK 1086-1263 7.5e-59 194.1 In-house 38-217 (314) alignment 
Range on Protein: 1086-1263
Range on HMM: 38-217/314.0
AVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHM
|    |  |||...||.|||.||.| ..|..  |||||...| ... |...|. ||||. |. |.||.....| ...||.|.|||.|.||| .|||.| .
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

PvlYGDIQVTMNQTFEENDWNIKEFAVQL----RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
   ||||.|.. .|  ...  .. |.|.      ...| ||...||.||||.|| | ..||...||. ......  .. |||
v..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC
0045098 (Phosphotyrosine protein) phosphatases II 1082-1263 1.6e-58 193.6 In-house 24-213 (278) alignment 
Range on Protein: 1082-1263
Range on HMM: 24-213/278.0
TTNTAVSPANVGKNRYTNILPYDRTRVKlspvddeegsDYINSNYIPGFtsPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWP
. ..|. . |. ||||..|||||..|||          |||| .||.|.  |...||.||||| |..| |||.||...|..||.|.|||.|..||.||||
eitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

DdHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ------LRDQRRYVRHWNFLSWPDHGVPESS--QALLAFIRRIRSTKP-------------PSSAPVA
. . .. |||..||. .. . .|. .  . |.        .. |.|.|...|.|||||||...  . .| ....||.                .|. ||.
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHC
|||
VHC
subfamily_PTPRG_pd Subfamily PTPRG 1078-1263 7.2e-58 191.2 In-house 34-227 (563) alignment 
Range on Protein: 1078-1263
Range on HMM: 34-227/563.0
GRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGS-DYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKC
 ........  | |  ||||.||..|||.||||||. ..... |||| ||| |.   ...|| ||||. |.|| |||||||||...||.|.|||.|. ||
skdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkc

DQYWPDdHMPVLYGDIQVTMNQT-----FEENDWNIKEFAVQLRD---QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
|.|||    .. || .|||. ..       ..   ||.. ..  .   . . ||.... .||||||||.|   | |...   ...    |. |||
dvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc
Y_phosphatase Protein-tyrosine phosphatase 1091-1263 1.2e-57 190.4 Pfam-A 1-177 (235) alignment 
Range on Protein: 1091-1263
Range on HMM: 1-177/235.0
NVGKNRYTNILPYDRTRVKLspVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWP-DDHMPVLY
|  ||||..|||||.|||||   ..|. ||||| ||. |.......||.||||. | .| |||.|...|...||.|.|.|||..||.|||| ... .. |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIQVTMN-QTF-EENDWNIKEFAVQLRDQR---RYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
|||.|..  ..  .|........ .. ....   | |... . .|||||||||...|| .||.....| ..|.|| |||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC
Y_phosphatase Protein-tyrosine phosphatase 1091-1263 1.2e-57 190.4 In-house 1-177 (235) alignment 
Range on Protein: 1091-1263
Range on HMM: 1-177/235.0
NVGKNRYTNILPYDRTRVKLspVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWP-DDHMPVLY
|  ||||..|||||.|||||   ..|. ||||| ||. |.......||.||||. | .| |||.|...|...||.|.|.|||..||.|||| ... .. |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIQVTMN-QTF-EENDWNIKEFAVQLRDQR---RYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
|||.|..  ..  .|........ .. ....   | |... . .|||||||||...|| .||.....| ..|.|| |||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC
subfamily_PTPN3_pd Subfamily PTPN3 1079-1263 3.7e-57 188.4 In-house 29-215 (280) alignment 
Range on Protein: 1079-1263
Range on HMM: 29-215/280.0
RKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSpvdDEEGsDYINSNY----IPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKV
.......|  |.|. |||| .||||| |||||.   ..|  ||||.||    ||. .    |||.||||. |. |.|.|.|||.....||.|.|||.|.|
pglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCDQYWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRD--QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
|| ||||. .  . ||...|..... |.. . ..|. .. ..  ..| . .  .|.|||||||..|. .| |..|.|...  .. || |||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC
subfamily_PTPRA_pd Subfamily PTPRA 1081-1263 5.3e-56 184.9 In-house 48-235 (330) alignment 
Range on Protein: 1081-1263
Range on HMM: 48-235/330.0
MTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYW
 | ..|    |  |||. |||||| .|| ||... .| |||||. .| |.    ..||.|||.  | .|.|||||||. .|.||.|.| |. . || |||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PDDHMpVLYGDIQVTMNQTFEENDWNIKEFAVQ------LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
||. . | ||.|.|..... . .|. ...| ||       ... | || . | |||| |||  .. .| .......... |. |. |||
PdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhc
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1080-1263 8.5e-56 184.4 In-house 45-230 (298) alignment 
Range on Protein: 1080-1263
Range on HMM: 45-230/298.0
KMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQY
. ... | .|.|  ||||..|...| .|| |. .|..| |||||  .. ...    .||.|.||. |. | |||..|....|.||.|.|.|..|.|. .|
eeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhky

WPDDHmPVLYGDIQVTMNQTFEENDWNIKEFAVQLRD--QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSS-APVAVHC
|||..    ||.|.|.. .. |  |  .....|. ..  ..| ||. .| ||||.|||| ....|...|..| ..  .  .|| |.|
wPdeg.ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqC
subfamily_Ptp69D_pd Subfamily Ptp69D 1080-1263 4.9e-55 181.8 In-house 37-226 (307) alignment 
Range on Protein: 1080-1263
Range on HMM: 37-226/307.0
KMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQY
. .|...    |  |||| .| ..|.|||||...  .| |||||...| |.   ...|| |.|. .| .| ||||.||.||..||...| || . ||..|
dkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY

WPDDhMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRD-------QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
||..   | |||| |.. .. . .|. |.|. |   .       ..| |  .....|.|  |||....|| .|...|. .  . .|. |||
Wpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhC
0037934 (Phosphotyrosine protein) phosphatases II 1084-1263 1.1e-54 181.0 In-house 3-185 (243) alignment 
Range on Protein: 1084-1263
Range on HMM: 3-185/243.0
NTAVSPANVGKNRYTNILPYDRTRVKLspvddeEGSDYINSNYIPGFtsPReYIACQGPLPGTTDD----MWRMIWEQNVTTVVMVTQLVEKGKVKCDQY
..| .|.|. ||||..|||||..||||      ||||||| |.|...  || .||.|||||.|..|     |||.||...|..||.|.|||.|..||.||
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPdDHMpvLYGDIQVTMNQTFEENDWNIKEFAVQL---RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRST--------KPPSSAPVAVHC
|| . .   |||..||. .. . .|. . .. ..     |. |.|.|. .|.|||||||.| . ||.|.. .|.         . .|. ||.|||
wp.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC
subfamily_PTPN6_pd Subfamily PTPN6 1081-1263 5.5e-54 178.2 In-house 44-234 (306) alignment 
Range on Protein: 1081-1263
Range on HMM: 44-234/306.0
MTTNTAVSPANVGKNRYTNILPYDRTRVKLSpVDDEEGSDYINSNYIPG--FTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQ
.. . .  | |  |||| ||||.| |||.|.  ..  ||||||.||| .   .| ..||| || |. |  | |||.|..| . .||.|. ||.|| || .
lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCar

YWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQ---LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSS----APVAVHC
|||| ..   ||.|.||. .  . .|....|. |.     .. |.|....| ||||||||.. .|.|.|.. ... .  ..     |. |||
YWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhC
subfamily_PTPN13_pd Subfamily PTPN13 1073-1263 7e-53 174.6 In-house 19-209 (273) alignment 
Range on Protein: 1073-1263
Range on HMM: 19-209/273.0
AIRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSpvdDEEGsdYINSNYIPGF--TSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVE
 .|..  . |.... . .|  |||| |.||||.|||||.   || |  |||...|         |||||||||| |..|.|.|.|||... ..|||. .|
elrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke

KGKVKCDQYWPDDHM-PV-LYGDIQVTMNQTFEENDWNIKEFAVQLRDQ--RRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPpSSAPVAVHC
||||||..|||. .  .. ... ..|.. .. . ........||.  .    | | | || .||||||| |.. || |....|. .  ...|..|||
kgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhc
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1068-1263 9.8e-53 174.5 In-house 38-231 (319) alignment 
Range on Protein: 1068-1263
Range on HMM: 38-231/319.0
VELTRAIRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTq
||  || ..     . . |  . |  |||..|||..|...||| ... ||.|||||. .. |. ..  |||.||||. | .|.||||||.|..|.|..| 
vefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.

lvekgKVKCDQYWPDDHmPVLYGDIQVTMNQTFEENDWNIKEFAVQL---RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIR--STKPPSSAPVAVH
     | || |||| .   . ..  .| ..   | ... .... .       . | .. . || |||.|||...  |. .....|   .|    |.. ||
.....kdkcsqywplki.vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvh

C
|
c
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1083-1263 2e-52 173.0 In-house 36-217 (315) alignment 
Range on Protein: 1083-1263
Range on HMM: 36-217/315.0
TNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPD
...|  . |  |||| ||||.|..||||  .||.  |||||. ||... . . ||| ||||. . ||.|||.....|||.||||.. |  |.|| |||||
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd

-DHMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
 .   | .| |.|.. ..    |  .... ..  .. | |  ..|  |||.||.. . .|| .|. ... . .   .. |||
rkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1084-1263 2.2e-52 172.7 In-house 2-182 (250) alignment 
Range on Protein: 1084-1263
Range on HMM: 2-182/250.0
NTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVkCDQYWPDD
. |  |.|  ||||..|...| .|| | ... .. |||||. .. |..  . .|| ||||. |. |.|||..|....|.||.|.|.|..|. . |||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

HmPVLYGDIQVTMNQTFEENDWNIKEFAVQLR--DQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPP-SSAPVAVHC
. .  |||..|.. .. |  |. .... .  .   ..| ||. .|..||| ||||  .| |...........   .||| |.|
k.aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1084-1263 2.5e-52 172.8 In-house 42-219 (315) alignment 
Range on Protein: 1084-1263
Range on HMM: 42-219/315.0
NTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDD
..|    |. |||| ||..||..||.|  .. ...|||.|.|.|.|.. .| |||.|||.. . .|.||...|......||.|.|||. | |...||||.
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

hmPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
   |.|| | ||. .   .... .. ..|  .|. | |  ... |||| |||... .|. .||...  .  | ... |||
..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhc
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1089-1263 2.7e-52 172.5 In-house 41-216 (515) alignment 
Range on Protein: 1089-1263
Range on HMM: 41-216/515.0
PANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPD-DHMPV
  |  |||| ||||||..||||  ..|.  |||.|. |||.| . . ||| |||.. ..||.||.....||||..|||.| |  |.|| .||||     |
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

LYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
 .| |.| .  .    .  .... |   |. | |  ..|  |||.|||. ...|| .|. ... .   . |. .||
kfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihc
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1068-1263 4.9e-52 172.2 In-house 2-195 (284) alignment 
Range on Protein: 1068-1263
Range on HMM: 2-195/284.0
VELTRAIRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTq
||  || ..     . . |  . |  |||...||..|...||| ... ||.|||||. .| |. ..  |||.||||. | .|.||||||.|..|.|..| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

lvekgKVKCDQYWPDDHmPVLYGDIQVTMNQTFEENDWNIKEFAVQL---RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIR--STKPPSSAPVAVH
     | || |||| .   . ..  .| ..   | ... .... .       . | .| . || |||.|||...  |.......|  ..|    |.. ||
.....kdkcsqywplki.vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

C
|
c
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1086-1263 5.6e-50 165.0 In-house 23-208 (274) alignment 
Range on Protein: 1086-1263
Range on HMM: 23-208/274.0
AVSPANVGKNRYTNILPYDRTRVKLS-PVDDEEGSDYINSNYIPGFTS-PREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDD
   . .  ||||..||| ...|| |.    ..| |.|||.||| |.    . |.| ||||| | .|.||||....|. .||.|.| |. . || .|.||.
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

HM---PVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPP---SSAPVAVHC
.       |||........ |.||...... ..   ..| | |. . .|||| .|.. ..|| ... .....       ||| |||
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1087-1263 5.3e-48 158.7 In-house 42-223 (305) alignment 
Range on Protein: 1087-1263
Range on HMM: 42-223/305.0
VSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMP
 . ||. |||...| ..|  |..|.. .... |||||..|. |. .  .||. ||||. | .| ||.|.|  |.|.||.|.||| || || ||||. .  
kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskte

-VLYGDIQVTMNQTFEENDWNIKEFAVQL---RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSA-PVAVHC
 . .|...|..... . .|. .... .      .. | | .... .|||||||... .|| .|.|.. ..  .   |. |||
kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1092-1263 5.7e-47 155.0 In-house 21-204 (270) alignment 
Range on Protein: 1092-1263
Range on HMM: 21-204/270.0
VGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFT-SPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDH---MPV
   |||..|||  .|||.|....... . ||| ||..||. ....||| .|||| |. . ||||||..||..||.|.|.|||. ||..||| .    . .
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

LYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQ------ALLAFIRRIRSTKPPS-S-APVAVHC
 .|.|.|.  ..  |. . ...  .. . ..| . |. . .|||||||....       ||. .| .| ..       |. |||
edgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc
subfamily_PTPN23_pd Subfamily PTPN23 1082-1263 2.1e-46 153.1 In-house 34-219 (288) alignment 
Range on Protein: 1082-1263
Range on HMM: 34-219/288.0
TTNTAVSPANVGKNRYTNILPYDRTRVKLSpvddEEGSDYINSNYIPGFTSP-REYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYW
 . .|..  .. |||...|||||..||||     ..  ||||  .. . ..   ..|| |.||..|  | |.|..|| . ..||...  |.|| |.|.||
krsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYw

PDDH-MPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQ--RRYVRHWNFLSWPDHGVPESSQALLAFIRRIRS----TKPPSSAPVAVHC
| |.  .| .||..||.... | . .  ... .. .|.   . |.| .. |||..|||.| . ||.|.  ..|    .. .| .|. |||
PedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1083-1263 1.8e-44 147.0 In-house 42-224 (297) alignment 
Range on Protein: 1083-1263
Range on HMM: 42-224/297.0
TNTAVS-PANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSprEYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKvKCDQYWP
..|      |  |.||.||||||. ||||  |.|.  |||.|. ...|.    ..|. | | . | .|.|.|.....|.|.||.... |. | || .||.
pqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

DDHMPVlYGDIQVTMNQTFEENDWNIKEFAVQLRD--QRRYVRHWNFLSWPDHGVPE--SSQALLAFIRRIRSTKPPSS-APVAVHC
|. .   .||. |... . | .    .|. |.  .  .|| |. ..|..|||. |..  | ..|| .|  .| .    . .|. |||
dkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhc
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1081-1248 3.2e-44 145.8 In-house 28-197 (287) alignment 
Range on Protein: 1081-1248
Range on HMM: 28-197/287.0
MTTNTAVSPANVGKNRYTNILPYDRTRVKLSpVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYW
.|  .|   |.| ||||...||.| ||| ||  . | ||||||.||....|   ..||.|||.. |  |.||...|.....|...|. ||... || .||
atfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw

PDDHMPVLYGDIQVT-MNQTFEENDWNIKEFAVQLRDQRR--YVRHWNFLSWPDHGVPESSQALLAFIRRI
|. ..|.. |   |. ....  | .. .. . .   . |    |.  ..|||||.... .. .|. |.  .
PerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1091-1263 1.4e-43 143.8 In-house 3-179 (237) alignment 
Range on Protein: 1091-1263
Range on HMM: 3-179/237.0
NVGKNRYTNILPYDRTRVKLSPVDDEegSDYINSNYIPGFT-SPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMPVLY
|  |||| ||  || .|| |     .  |||||..|. ||  .|..|||.||||  . ||.|.|.|... . .||.| |.|. ..|| .|||. . |  |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDIQVTMNQTFEENDWNIKEFAVQLRDQRR---YVRHWNFLSWPDHGVPESSQALLAFIRRI--RSTKPPSSAPVAVHC
| . |.. .  |  |. .. . .. | . .   ..  ..| ||||.|||. . ||| | ..|  || . . |.|  .||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihc
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1076-1263 3.8e-43 142.4 In-house 31-223 (290) alignment 
Range on Protein: 1076-1263
Range on HMM: 31-223/290.0
KVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEG--SDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGK
.  .. |....... |  .||..||..||  |. | |. ...    .|||  || |.   ..||| |||.. |  | |..||...|| .||.|. .|.||
sgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegk

VKCDQYWPDDHMPVlYGDIQVTMNQTFEENDWNIKEFAVQLRDQ---RRYVRHWNFLSWPDHG-VPESSQALLAFIRRIRSTKPPSSAPVAVHC
||| |||||      || .......  . |.  .... |. ...   .. | .... .|...| |.. .  ||.. ....  . .   .. |||
vkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHC
subfamily_PTPN1_pd Subfamily PTPN1 1069-1263 3.9e-43 142.2 In-house 10-208 (290) alignment 
Range on Protein: 1069-1263
Range on HMM: 10-208/290.0
ELTRAIRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDeegsDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQL
|. . |||  ....|..|  |.| ..||| .. ||| .|.||   |     ||||.. .      |.||  ||||| |.| .|.|.|||.  .|||. ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

VEKGKVKCDQYWPDDH--MPVLYGDIQVTMNQTFEENDWNIKEFAVQLRD----QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTK--PPSSAPVA
|||...|| |||| ..    .|. |......   ||.  . .   ..| .    . | . |. ...||| ||||| .|.| |. ..|..    .   |. 
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpav

VHC
.||
ihc
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1083-1263 1.5e-41 137.3 In-house 39-218 (287) alignment 
Range on Protein: 1083-1263
Range on HMM: 39-218/287.0
TNTAVSPANVGKNRYTNILPYDRTRVKLSpvddEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPD
   .... |  |||.|.||..|  || |     .|  ||||. .| |. . ...|....|.  |  ..|..|...|||..||..|. |. . .| ||||.
vthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe

DHMpVLYGDIQVTMNQTFEENDWNIKEFAVQLRD---QRRYVRHWNFLSWPDHG-VPESSQALLAFIRRIRSTKPPSSAPVAVHC
..  |..|. .... .   .... .... |. ..   ... |. ... .|...| |.|    || . ..... . .. ... |||
eks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC
subfamily_PTPN14_pd Subfamily PTPN14 1074-1252 2.6e-41 136.6 In-house 32-216 (300) alignment 
Range on Protein: 1074-1252
Range on HMM: 32-216/300.0
IRKVGRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEeGSDYINSNYIPG--FTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEK
| |   . ...||  | |. |||. ..|||. .||.|||  ..  ..|||.  |     .. |.||..||||. |  |.|.|.|||.|. .||.|.  |.
ipkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

GKVKCDQYWPDD---HMPVLYGDIQVTMNQTFEENDWNIKEFAVQ--LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTK
|| |. .|.|..   .  | .|  .|| . . . .    . . ..  .  ..| | |  .  ||||||||  .  | ......| .
gkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1086-1245 3.5e-41 136.0 In-house 28-190 (297) alignment 
Range on Protein: 1086-1245
Range on HMM: 28-190/297.0
AVSPANVGKNRYTNILPYDRTRVKLSPVDdeEGSDYINSNYI--PGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDD
|  .. . ||||..|| .| |||||  |    ..||||..|.  |   ..  ||  ||||  | || |....||.| ..|||..| | |. ||  |||. 
akrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

HMP-VLYGDIQVT-MNQTFEE-NDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFI
       ||. |  . .| .| .   . |. .  |...|.||| .||||||||||   . |  | 
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1090-1263 8.6e-38 124.8 In-house 7-181 (239) alignment 
Range on Protein: 1090-1263
Range on HMM: 7-181/239.0
ANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGF-TSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHmpVL
 |  ||||.||. ||..|| |  . ..  |||||..|.  .  ||. ||| || .  .. |.|||.|..    .||.| |.|  | || |||||      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGDIQVTMNQTFEENDWNIKEFAVQLRD--QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
| ...||. .|    |. |. | .      . ||| .. |  |||.|||. . |.| . |.|     | . |  .||
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1090-1263 1e-37 124.6 In-house 6-180 (239) alignment 
Range on Protein: 1090-1263
Range on HMM: 6-180/239.0
ANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGF-TSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHmpVL
 |  ||||.||. ||..|| |  . ..  |||||..|.  .  ||. ||| || .  .. |.|||.|..    .||.| |.|  | || |||||      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGDIQVTMNQTFEENDWNIKEFAVQLRD--QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
| ...||. .|    |. |. | .      . ||| .. |  |||.|||. . |.| . |.|     | . |  .||
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc
subfamily_PTPRN_pd Subfamily PTPRN 1081-1263 1.5e-37 124.0 In-house 46-231 (297) alignment 
Range on Protein: 1081-1263
Range on HMM: 46-231/297.0
MTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGfTSPRE--YIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQ
 |...| .. || |||....|||| .||||.   ..| |||||.  |   . ||.  |||.||||. |  |.|.|.||| |. .|..|.| |.|  .|..
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPDDHMPVlYGDIQVTM-NQTFEENDWNIKEFAVQ-LR-DQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
||||.   | |.  .| .  .    .|. .. | .. |. .. | |  . |||||..||| |...|| | |..  .    |.|. |||
ywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1083-1263 2.4e-37 123.3 In-house 37-176 (392) alignment 
Range on Protein: 1083-1263
Range on HMM: 37-176/392.0
TNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGkvkcdqywpd
...|  . |. |||| ||||||..||||  .||   |||.|. |||.| . . |||.||| . . ||.|||....||||..|||.| |            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

dhmpvlygdiqvtmnqtfeendwnikefavqLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
                                 |. | |  . |  |||..||. . .|| ||. ...     . |. .||
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1082-1263 4.9e-37 122.8 In-house 39-228 (325) alignment 
Range on Protein: 1082-1263
Range on HMM: 39-228/325.0
TTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMI--WEqnvTTVVMVTQLVEKGKVKCDQY
. ..|. |.|. |||. |....|..|| |   .|.  |||||..|.  .     ..|.| ||. |..|.||..  |.   ..||.|.  ...|| .| .|
akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavy

WPDD-HMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQR--RYVRHWNFLSWPDHGVPESSQALLAFIRRIRS------TKPPSSAPVAVHC
||..    . .| ..| .    |  |.  . . |.  ..   | |. ... ||.| ||..   .|..... .        ..  .|.|. |||
wpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc
subfamily_CG7180_pd Subfamily CG7180 1084-1263 3.6e-35 116.0 In-house 35-230 (296) alignment 
Range on Protein: 1084-1263
Range on HMM: 35-230/296.0
NTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKvKCDQYWPDD
 ...   | .|||. ...||| .|| |. .| || |||||. |. .|. ..|||  ..|   | |. ||....... .||..|.  .  | .. .||| .
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

HmPVLYGDIQVTMNQTFEENDWNIKEFAVQLR------------DQRRYVRHWNFLSWPD-HGVPESSQALLAFIRRIRSTKP-----PSSAPVAVHC
     ||.| | . .. .  . .|..| .. .             . | |.. ..  |.  . || |..||. ..||.|. .      |  .|| |..
s.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs
0041856 (Phosphotyrosine protein) phosphatases II 1091-1263 4e-35 116.4 In-house 1-116 (182) alignment 
Range on Protein: 1091-1263
Range on HMM: 1-116/182.0
NVGKNRYTNILPYDRTRvklspvddeeGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTqlvekgkvkCDQYWPDDHmpvlyg
|. ||||..|||||..|          ..|||| |.. |   ....||.||||..|. |..||..|...||.|..|         ...|||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

diqvtmnqtfeendwnikefavqlrdqRRYVRHWNFLSWPDHGVPEsSQALLAFIRRIRStkppSSAPVAVHC
                            |.. .. .|.|||||||.  . ||.||.....    .. ||.|||
...........................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHC
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1080-1263 3.8e-34 112.9 In-house 22-206 (283) alignment 
Range on Protein: 1080-1263
Range on HMM: 22-206/283.0
KMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDeegsDYINSNYIP---GFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKC
.. .. |..  |  |||. .|.|.|. ||.| .       ||||. .||        ..||..|.||  |  |.|.|......|..||.|.| |  ..||
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

DQYWPDDHmPVLYGDIQVTMNQTFEENDWNIKEFAVQLR---DQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
 |||| .   . ||.  ||... . .| . |||. ..      .   . |. .  | . |      .|. | . |   .    .|. |||
sqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhC
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1092-1263 5.4e-34 112.4 In-house 49-219 (439) alignment 
Range on Protein: 1092-1263
Range on HMM: 49-219/439.0
VGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKvkcdqYWPDDHmPVLYGD
  |||| .. ..| ||| |  .     | |||.||| |.  .. |||.|||   ||||.||...|....|.||.|.|||  |     ||| |   | |||
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda.evcygd

IQVTMNQTFEENDWNIKEFAVQL-RD---QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPP-SSAPVAVHC
| | ...  |  .. |. | |   ||   . | | .. ...|||. ||  .  .| |.| | |..      || |||
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhc
subfamily_ptpA1_pd Subfamily ptpA1 1088-1249 7.1e-34 112.2 In-house 44-216 (418) alignment 
Range on Protein: 1088-1249
Range on HMM: 44-216/418.0
SPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGfTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHM--
   |  ||||||||| ..|||.|  ..|.|||||||.||| | . |...|. ||||| |  |.|||.||. .  .||...  |. ..|||.|||..    
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

-PVL-------YGDIQVTMNQTFEENDWNIK--EFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIR
   .       .|   | . .  .. . .|   .  . .  . | . ....  |||| .|. .| .  ... | 
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit
subfamily_CG42327_pd Subfamily CG42327 1080-1251 1.5e-33 110.9 In-house 17-193 (319) alignment 
Range on Protein: 1080-1251
Range on HMM: 17-193/319.0
KMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFT-SPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQ
 ..   .| ..   |.|. |..|   ||| |  . |.. . |....|. |.  .|  |||.| .|  .. |.||..|||.  ..| .|.| |.|  .| .
liaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcae

YWPDDHM---PVLYGDIQVTMNQTFEENDWNIKEFAVQLRD--QRRYVRHWNFlSWPDHGVPESSQALLAFIRRIRST
|.|         |||||.||. .   .. . |  . ..  |  . | . |. .  |.. .|| . .||.| . ..||.
ylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1088-1263 1.2e-32 107.7 In-house 34-207 (281) alignment 
Range on Protein: 1088-1263
Range on HMM: 34-207/281.0
SPANVGKNRYTNILPYDRTRVKLSP-VDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDD-HM
 | |  ||||.||   | .||.|   . ... .||| .|||      | ||  |||   |  |.|||||..| |..||. |..|  . || .|.| . | 
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

PVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTkppsSAPVAVHC
 . .  . |. ...  ..      . .    . | . || .  |||  |||||. .|  .|.||.     |.|  .||
clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihc
0051429 (Phosphotyrosine protein) phosphatases II 1118-1263 1.5e-32 108.8 In-house 3-157 (272) alignment 
Range on Protein: 1118-1263
Range on HMM: 3-157/272.0
GSDYINSNYIPGFTS---PREYIACQGPLPGTTDDMWRMiWEQNVTTVVMVTQLVEKGKVKCDQYWP-----------DDHMPVLYGDIQVTMNQTFEEN
 |.||| ....|...   |. .....|||| | .| ||. .|....|.|......|.|..|||.|||           |.....|||.. ||. ...  .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DWNIKEFAVQ---LRDQRRYVRHWNFLSWPDHGVPESSqaLLAFIRRIRStkppsSAPVAVHC
|. . |. .      .. | |.|. ...|||||||...  ||.... ...     . || |||
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHC
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1091-1263 4.3e-32 105.9 In-house 56-223 (290) alignment 
Range on Protein: 1091-1263
Range on HMM: 56-223/290.0
NVGKNRYTNILPYDRTRVKLSpvdDEEGSDYINSNYIPGFTSPreYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMPVL-Y
.. |||| ..   |.||| |.   |    ||. .||. |  ..  .|  ||.|  |. |.|||. ...|...||. .|.|.|| ||.||.|. .  || .
efkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GDIQVTMNQT-FEENDWNIKEFAVQLRDQ--RRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTkppsSAPVAVHC
|.| |.  .   ....   | ..|. .|.     ..|..  ||||. |. |. |||  .| .| .    | ||.|||
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhc
0049772 (Phosphotyrosine protein) phosphatases II 1075-1263 4.5e-32 107.4 In-house 30-219 (314) alignment 
Range on Protein: 1075-1263
Range on HMM: 30-219/314.0
RKVGRKMTTNTAVSPANVGKNRYTNILPYDrTRVKLsPVDDEEGSDYINSNYIPGFtspREYIACQGPLPGTTDDM----------WRMI--WEQNVTTV
  | ...|. .|  ..|  ||||..|||.| .||.| |  . .||||||..|. ||   . .||.||||. | .|           |||.  ...|| ..
lsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

VM---------------------VTQLVEKGkvkcdQYWPDDHMPVLYgdiqvtmnqtfeenD-------WnikefavqlrdqRRYVRHWNFLSWPDHGV
||                      ..| ..|      ...  ... |               .       .             |.. ..  . .||...
vmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf............erlgikylripvpDgsa

PeSSQALLAFIRRIRSTkpPSSAPVAVHC
| ... ...|.. |..   .   ||.|||
p.lledfdeflefieea..dkggpvlvHC
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1078-1263 4.8e-30 99.6 In-house 30-216 (307) alignment 
Range on Protein: 1078-1263
Range on HMM: 30-216/307.0
GRKMTTNtAvSPANVGKNRYTNILPYDRTRVKLSpvDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCD
   .|.. |   ||  ||||...   |..|. .    |   |||| .||.   . |. .|..||||  |  ..| |. ...| .|.|. ...| .|.||.
pegvtve.a.fsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikce

QYWPDDH-MPVLYGDIQVTMN--------QTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRStkppSSAPVAVHC
|||| ..     .|.   |..         . .|.  |. .. |.  .. | ..|...  |||.|||.   . . ..  .|        || |||
qywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhc
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1082-1263 1e-29 98.2 In-house 31-233 (301) alignment 
Range on Protein: 1082-1263
Range on HMM: 31-233/301.0
TTNTAVSPANVGKNRYTNILPYDRTRVKLSPVD--DEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQY
...  .| .|   ||. || .||  |. |.|    |    .|||..|| |... ...|| |||.  |  |.||.||.. ....||||.| |. | || ||
sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqy

WPDD-HMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRR-----------------YVRHWNFLSWPDHGV-PESSQALLAFIRRIRSTKPPSSAPVA
||.  .    .| ..||....    |. |....|...|                     |  ..  .||..|| .|    | .    |  .. .. .|| 
wpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvv

VHC
|||
VHC
0036282 (Phosphotyrosine protein) phosphatases II 1118-1263 5.4e-29 96.5 In-house 1-111 (174) alignment 
Range on Protein: 1118-1263
Range on HMM: 1-111/174.0
GSDYINSNYIPGFTSPREYIACQGPLPgttddMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDdhmpvlygdiqvtmnqtfeendwnikefavQLRDQ
|||||| ... ..  ....||.||||.      |.|..|...|||||.....|.|..|| .|||.                                 | 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

RRYVRHWNFLSWPDHGVPESSQaLLAFIRRIRSTKPP-SSAPVAVHC
.|.. .. .| |||||||..|. || |......     .. ||.|||
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC
0043147 (Phosphotyrosine protein) phosphatases II 1116-1263 1.4e-27 91.9 In-house 2-107 (172) alignment 
Range on Protein: 1116-1263
Range on HMM: 2-107/172.0
EEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLvekgkvkcdqywpddhmpvlygdiqvtmnqtfeendwnikefAVQLR
.||||||| .|...   |...||.||||. |..| |||..|...|..|..|.|                                           .   
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

DQRRYVRHWNFLSWPDHGVPeSSQALLAFIRRIRS-TKPPSSAPVAVHC
.  |.. .. .|.||||||| ... || |.. |..     .. ||.|||
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHC
0049260 (Phosphotyrosine protein) phosphatases II 1126-1263 6.1e-27 89.6 In-house 1-96 (152) alignment 
Range on Protein: 1126-1263
Range on HMM: 1-96/152.0
YIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWpddhmpvlygdiqvtmnqtfeendwnikefavqlrdqrryvrHWN
.|.|.  |.|.||.|||.| |..| |||..|...||.||.|.|.|.||.||.||.                                          .. 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
.| |||||||..|| || ... |.  .  .. ||.|||
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHC
0046846 (Phosphotyrosine protein) phosphatases II 1114-1263 1.4e-26 88.7 In-house 7-116 (176) alignment 
Range on Protein: 1114-1263
Range on HMM: 7-116/176.0
DDEEGSDYINSNYIPGFtsprEYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDdhmpV----Lygdiqvtmnqtfeendwnike
 .....|||| |.| |      .||.|||||.|. | ..|..|...|.||..|..||.|..||..|||.    .    .                     
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi.....................

favqlrdqrryvrHWNFLSWPDHGVPESsQALLAFIRRIRSTKPPSsAPVAVHC
             .. .| |||||||.. ..|| ... ||.       ||.|||
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHC
0044763 (Phosphotyrosine protein) phosphatases II 1102-1263 2e-25 84.9 In-house 1-117 (178) alignment 
Range on Protein: 1102-1263
Range on HMM: 1-117/178.0
PYDRTRVKLSPVDDEEGSDYINSNYIPGFtsprEYIACQGPlpgttDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMpvlygdiqvtmnqtfe
|.|||||.||.. ..|.||||| ..| ..     |.....|      | .....|...|..|..|. .| |..|||.|||...                 
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

endwnikefavqlrdqrryvRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSSAPVAVHC
                     .. .. .||||||.... .|.|.. |..  ...  ||.|||
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHC
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1085-1263 2.1e-25 84.0 In-house 48-228 (305) alignment 
Range on Protein: 1085-1263
Range on HMM: 48-228/305.0
TAV-SPANVGKNRYTNILPYDRTRVKLspvDDEEGSDYINSNYIPGFTSP-REYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPD
.   .  .. ||||...   |.. |||   |.   |||| .||.     | . .|..||||  | |..| |. ...|  .||. . || ||.|| |||| 
anqsadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa

DHM--PVLYGDIQVTM-N-QTFEENDWNIKEF--AVQL-RDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKppssAPVAVHC
 .     | . | |         | | .|.     .    ||.  ||| ..  ||| |||    . | ..  || .|     |. |||
aqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1093-1209 2.7e-25 83.9 In-house 49-174 (350) alignment 
Range on Protein: 1093-1209
Range on HMM: 49-174/350.0
GKNRYTNILPYDRTRVKLS----PVD----DEEGSDYINSNYIPGF------TSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQ
 ||||.|||||...||||     . |      ...||||.||.          .   ||| |.||| | ||....| . .|. ....|..|| .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDDHmpvlYGDIQVTMNQTFeENDWNIKE
||..      | ||.| ....  ||  .|..
YWqegs....ydditvklaskw.enimgind
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1090-1263 5.3e-25 83.0 In-house 42-211 (288) alignment 
Range on Protein: 1090-1263
Range on HMM: 42-211/288.0
ANVGKNRYTNILPYDRTRVKLSpvDDeeGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMP-VL
||  ..||.|.   | ||||||  ||     ||..| ..    .|  | .| || || . .|.|. |..|  .||...|.|||| | ..|.|      . 
anptrdryenlprcditrvkls..dd..pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGDIQVTMNQTFEENDWNIKEFAVQ---LRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKppssAPVAVHC
.| .   . .  .. |  .|   ..     ... .|..  .| |.|.||||. .. | .. ...|..     |. ||.
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1091-1263 2.7e-24 80.5 In-house 48-226 (305) alignment 
Range on Protein: 1091-1263
Range on HMM: 48-226/305.0
NVGKNRYTNILPYDRTRVKLSPVddeEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMPVLYG
. ||||| ..   |. |||| .       .|| .||.   | |. .| .| ||  |  |.| | ....| .. |. .|.|||  || .|.. .. .||  
eagknrykdvgcldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

---D--IQVTM----NQTFEE-NDWNIKEFAVQLR---DQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKppssAPVAVHC
   .  |.| .    .  |..  . ...|  . .     . | | |. .  ||| ||| . .|.| .. . |..|     |..|||
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhc
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1090-1214 6.4e-21 69.2 In-house 51-173 (310) alignment 
Range on Protein: 1090-1214
Range on HMM: 51-173/310.0
ANVGKNRYTNILPYDRTRVKLSpVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMPVLY
 .. ||||....  | .||||  .|     ||| .||.        .| .||||  |  |.||||...   ..... . .|.|. ||  |||   .   |
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GDIQVTmNQTFEENDWNIKEFAVQL
| |.|| | .   ....| ..|| .
gcirvt.nlsesseefeicnlavtf
0051082 (Phosphotyrosine protein) phosphatases II 1118-1263 1.1e-20 69.3 In-house 2-99 (151) alignment 
Range on Protein: 1118-1263
Range on HMM: 2-99/151.0
GSDYINSNYIPGFtspreYIACQGPlpgtTDDMWRMIWEQNVTTVVMVTQLVEKGkvKCDQYWPDDHmpvlygdiqvtmnqtfeendwnikefavqlrdq
 ||||| .|. |.     .....||    ..| .....|....|.|......| |  .| .|.|.                                   
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

rRYVRHWNFLSWPDHGVPESSQALLAFIRRIRStkpPSSAPVAVHC
 . |.|. .|.|||.|.|.| .|.|.|.. ...   ... ||.|||
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHC
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1081-1263 1.2e-20 68.5 In-house 42-221 (301) alignment 
Range on Protein: 1081-1263
Range on HMM: 42-221/301.0
MTTNTAVSPANvgKNRYTNILPYDRTRVKLspVDDEEgSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYW
.|   |  | .  |.|| ..     | |..  ..| .    | .|.||    |. .|| ||||. |..|.| |.   .| ..||..| ||| . ||..| 
itesyaylpkd..khryptvPckPstavev..ivdGk.rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeyl

PDDHMP-VLYGDIQVTMNQTFEENDWNIKEFAVQLRD-----QRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRStkppSSAPVAVHC
| .    .  |  .......    . .|.. .....|     . | | |... .|.|.|||.|   |  ..  ..     |  |. |||
pvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1083-1263 1.1e-18 62.2 In-house 28-210 (285) alignment 
Range on Protein: 1083-1263
Range on HMM: 28-210/285.0
TNTAVsPANVGKNRYTNILPYDRTRVKLSPVDdeegSDYINSNYI--PGFTsPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYW
| ||   ||   |||...   . ||| |   |     ||| ....  ||      ||. ||||| |  |.|.||...... |.|.  |.| |  ||  |.
tytay.eanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PDDHMPV-LYGDIQVTMNQTFEENDWNI--KEFAV----QLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPpSSAPVAVHC
|.    |  .|  ..|. .  ||       . ..|    .   .  |. | .   |||.  || .. .. . . ..  .|    |..|||
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhc
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1080-1217 3.2e-18 60.7 In-house 21-153 (267) alignment 
Range on Protein: 1080-1217
Range on HMM: 21-153/267.0
KMTT-NTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEegsdYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVeKGKVkcDQ
. .|  . ..  |  .||. . |||| ||| |.  ..|    |||. |. |.   . .|. |.||  |  | . .| .|.|...|..|.   ....   .
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvf.tdni..rl

YWPDD-HMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQ
.||        | |. |  .   ||||..|  . ......
fwPPkmgqakkyqdltvehslekeendyqiitlelkfkne
subfamily_egg_pd Subfamily egg 1080-1226 1.1e-17 58.7 In-house 29-179 (307) alignment 
Range on Protein: 1080-1226
Range on HMM: 29-179/307.0
KMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKgkVKCDQY
... .||.|  |  | |   .   | .||||         |.| .|.. |     |.| .| ||  | ||.|||.....|  .||.|  .|    .|. |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPD---DHMPVLYGDIQVTMNQTFEENDW--NIKEFAV-QLRDQRRYVRHWNF
||    | . .. | ....  .  .. |   .. .. .    |. |.. ||. 
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1094-1256 1.9e-17 57.9 In-house 46-213 (312) alignment 
Range on Protein: 1094-1256
Range on HMM: 46-213/312.0
KNRYTNILPYDRTRVKLSpvDDEEgsDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMPVLYGDIQ
 ||| ||  .|| |  |.   ||.   || .|..   | |  ....||||  |.  .|..      |...... .|| |  || .|  |    |   | .
lnrypniqcwdrgrftla..gden..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

VTMNQTFEE---------NDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSS
|  ..  |              .    |.   |   . |... ||||||.|.| .. | ..  ..  | |  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpvi
subfamily_eak_pd Subfamily eak 1079-1251 6.3e-17 56.0 In-house 40-210 (332) alignment 
Range on Protein: 1079-1251
Range on HMM: 40-210/332.0
RKMTTNTAVSPANVGKNrYTNILPYDRTRVKLSPVDDEeGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQ
| .. . .    .| .|   .|.||||  |.|..   .    |||.  .      |.||    .       .|.|. ||.  ..|.. . ||..  | |.
rllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdk

YWPDDH-MPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPESsQALLAFIRRIRST
|.||.    . .| ..|.  .  ..|  . . . ..  ..   | |...  | .  .|   . .||. . .. .
yfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpky.edflalrkvmkev
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1093-1200 2.7e-15 50.5 In-house 50-169 (349) alignment 
Range on Protein: 1093-1200
Range on HMM: 50-169/349.0
GKNRYTNILPYDRTRVKLSPV--------------DDEEGSDYINSNYI--PGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKC
 |||| .||||. .||||                 |     ||||.||.  . ..  . ||| | ||| | || ...|  ..|  |. ...  |..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPDDHmpvlYGDIQVTMNQTF
|.|| .      | .|.| .. ..
diywqels....ysnitvklqnss
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1072-1248 2.6e-14 47.5 In-house 30-201 (303) alignment 
Range on Protein: 1072-1248
Range on HMM: 30-201/303.0
RAIRKVGRKMTTNTAVSpaNVGKNRYTNILPYDRTRVKLSpvdDeegSDYINSNYIPgFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEK
. .  .  ... |  |.  |. |||.....  | ..||||   |   | || ..|.  . | .  |  | ||. |. |.|.|| ||.|  |...    | 
kvvsylppsvsknqfvk..nmdknrfvdvicldhskvkls...d...ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdsey

GKVKCDQYWPDDHMPVLYGD--IQVTMNQTFE-ENDWNIKEFAVQLRDQRRYVRHWNFLSWPDHGVPES-SQALLAFIRRI
 |.  |  .| .   . . .  |.|   .  |  . |..|  .|   | . ..    . .||   .|   |  ..  | ..
dklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwql
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1095-1263 9.9e-12 39.6 In-house 23-198 (290) alignment 
Range on Protein: 1095-1263
Range on HMM: 23-198/290.0
NRYTNILpYDRTRVKLSPVDDEEGSDYINSNYIPgFTSPREYIACQGPLPGT-------TDDMWRMIWEQNVTTVVMVTQLVEKGKV----KCDQYWPDD
.|... |    ||| |        .|||  |..  . .  . |. | |.  .         . | |. . .|. |||. .  || .      | .| |. 
qRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

HM-PVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRY-VRHWNFLSWPDHGVPESSQALLAFIRRIRStkppSSAPVAVHC
    . .....|   .  .|.| ...|  |.  |.. . | |  . .| .  |.|... ||. |. ..     | .|| |||
vgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHc
fn3 Fibronectin type III domain 712-787 2e-11 37.1 Pfam-A 2-82 (85) alignment 
Range on Protein: 712-787
Range on HMM: 2-82/85.0
PPQNVTVTNVTEQSITIAWTPG---AGYRTRYHLHAYAT-SYS-EEVGVVHGDVTDFTFHNLLAGTRYIITIRASANDTDG
.|.|..|..||. |.|. |.|     |  |.| ..   . . . .    | .. | .|...| .||.| ....|  ... |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1078-1129 2.6e-11 37.6 In-house 26-76 (244) alignment 
Range on Protein: 1078-1129
Range on HMM: 26-76/244.0
GRKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVdDEEGSDYINSNYIPG
 |..    ||  ||. |||| ||||.| ||| ||    .|||||||.||| |
treflqtnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1146-1263 2.7e-11 38.1 In-house 40-155 (255) alignment 
Range on Protein: 1146-1263
Range on HMM: 40-155/255.0
TTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHM-PVLYGDIQVTMNQTFEENDWNIKEFAVQLR--DQRRYVRHWNFLSWPDHGVPESSQALL
| | ....|  .. ..|||.. . |.|..||..|.| ..     . |..||  ..  .      |   .|    . . |.|...  |...  || .. .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

AFIRRIRSTKppssaPVAVHC
  .. .| .|     .| |||
nilkvvrdsk.....svvvhC
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1085-1141 5.7e-11 36.5 In-house 42-95 (95) alignment 
Range on Protein: 1085-1141
Range on HMM: 42-95/95.0
TAVSPANVGKNRYTNILPYDRTRVKLSPVDDeegSDYINSNYIPGFTSPREYIACQG
.  | ||. |||. ||.||| ||| |.   |   |||||. .. |..    |||.||
vgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1101-1214 2.4e-10 34.8 In-house 3-102 (130) alignment 
Range on Protein: 1101-1214
Range on HMM: 3-102/130.0
LPYDRTRVKlspvddeeGSDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQlVEKGkvkcDQYWPDDHmPVLYGDIQVTMNQTF
|... .|..        | .||| ...      .||.  | ||  |. |.|.|. |. |  .|..   ||.     |.||||   |. . . ....  | 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdse.Plewyeediivtltd

EENDWNIKEFAVQL
 ..  |||   .. 
rdefknikasnlei
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1133-1263 3.6e-10 34.3 In-house 4-142 (199) alignment 
Range on Protein: 1133-1263
Range on HMM: 4-142/199.0
PREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHM-PVLYGDIQVTMNQTFEENDWNIKEFAVQ----LRDQRRYVRHWNFL
 | |||.| ||  |  |.|.|.||     .||| .   . ..    |||  .     || . || .    . |. |  . .          | . |..| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPESSQaLLAFIRRIR--STK--PPSSAPVAVHC
|| ..  |. .  .. |.   |  | |      ||| |||
swkekttpnval.fvgfvvasrevskkyeqekdapvivhc
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1134-1263 3.7e-10 34.3 In-house 4-141 (198) alignment 
Range on Protein: 1134-1263
Range on HMM: 4-141/198.0
REYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHM-PVLYGDIQVTMNQTFEENDWNIKEFAVQ----LRDQRRYVRHWNFLS
| |||.| ||  |  |.|.|.||     .||| .   . ..    |||  .     || . || .    . |. |  . .          | . |..| |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPESSQaLLAFIRRIR--STK--PPSSAPVAVHC
| ..  |. .  .. |.   |  | |      ||| |||
wkekttpnval.fvgfvvasrevskkyeqekdapvivhc
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1130-1231 5.4e-10 33.2 In-house 232-330 (440) alignment 
Range on Protein: 1130-1231
Range on HMM: 232-330/440.0
FTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQLVEKgkvKCDQYWPDDHMPVLYGDIQVTMNQTFEENDWNIKEFAVQLRDQRRYVRHWNFLSW
..    .|| | ||  |  |.||.. . ...|..|. || .|    |  ||| .   | .| . |  . . . |  ... . .. ...   .| ..  .|
yskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtw

PD
| 
pt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1090-1166 7.2e-10 32.9 In-house 36-117 (347) alignment 
Range on Protein: 1090-1166
Range on HMM: 36-117/347.0
ANVGKNRYTNILPYDRTRVKLSPVDDEEG-----SDYINSNYIPGFTSPREYIACQGPLPGTTDDMWRMIWEQNVTTVVMVT
 .. |||  .    | ||| ||| . . .       |||. .|    . .|||  | ||| |  |.|.|.   .|| || . 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0048076 (Phosphotyrosine protein) phosphatases II 1178-1263 1.3e-09 33.4 In-house 36-88 (145) alignment 
Range on Protein: 1178-1263
Range on HMM: 36-88/145.0
QywpddhmpvlygdiqvtmnqtfeendwnikefAVQLRDQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSsAPVAVHC
                                 .  |..  |.. .. .|.|||||||.... ||.|.. |..  .    ||.|||
l................................tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHC
fn3 Fibronectin type III domain 807-888 4.8e-09 29.4 Pfam-A 6-83 (85) alignment 
Range on Protein: 807-888
Range on HMM: 6-83/85.0
LRLEPQiDHRQIRLAFLAPMLPNGVLEGYRVEYVGKRNGSrtcSSGQKYLPVVETSVIIEGLKGGCYYTFTVKARNEVGLGP
|.....  .....| . .|  ..| ..||.|||  |..|.    . .. .|  .|||...||| |  |.|.|.|.|..| ||
lsvsev.tstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_hpo-7_pd Subfamily hpo-7 1146-1252 6.2e-09 30.1 In-house 46-155 (263) alignment 
Range on Protein: 1146-1252
Range on HMM: 46-155/263.0
TTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDH-MPVLYGDIQVTMNQTFEENDWNIKEFAVQLR--DQRRYVRHWNFLSWPDHGVPESSQALL
| | ....|  .. ..|||..   |.|..||..|.| ..     . ...|.  .. ..     .|.  .|    . . |.|. .  |...  || ..  |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

AFIRRIRSTK
  ..  |  |
nilkvarnsk
0048179 (Phosphotyrosine protein) phosphatases II 1204-1263 1.6e-08 29.9 In-house 48-90 (144) alignment 
Range on Protein: 1204-1263
Range on HMM: 48-90/144.0
DwnikefavqlrdqrryVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPpSSAPVAVHC
                 . .. .|.|||||||.... ||.|.. |..  . .. ||.|||
e................giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHC
PTPc_DSPc_SM00012 1221-1263 3.3e-08 29.1 In-house 2-46 (105) alignment 
Range on Protein: 1221-1263
Range on HMM: 2-46/105.0
VRHWNFLSWPDHGVPESSQALLAFIRRIRSTKPPSS--APVAVHC
|.|  ...||||||||.|...| ..| ... |  |.  .|| |||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhC
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1089-1182 5.1e-08 26.0 In-house 25-86 (169) alignment 
Range on Protein: 1089-1182
Range on HMM: 25-86/169.0
PANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSnyipgftspreyiacqgplpgttddmwRMIWEQNVTTVVMVTQLVEKgkvkcDQYWPD
 .|  ||| .  |   .|||||  | .. ||||||.                           ||||| | . .|.. .  .|     ...||.
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpe
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1090-1182 7.6e-08 25.4 In-house 25-85 (169) alignment 
Range on Protein: 1090-1182
Range on HMM: 25-85/169.0
ANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSnyipgftspreyiacqgplpgttddmwRMIWEQNVTTVVMVTQLVEKgkvkcDQYWPD
.|  ||| .  |   .|||||  | .. ||||||.                           ||||| | . .|.. .  .|     ...||.
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpe
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1091-1176 1.1e-07 25.6 In-house 34-118 (332) alignment 
Range on Protein: 1091-1176
Range on HMM: 34-118/332.0
NVGKNRYTNILPYDRTRVKLSPVDDEEgsDYINSNYIPGFTSPREYIACQGPLPGTTDD-MWRMIWEQNVTTVVMVTQLVEKGKVKC
|.  ||   .  .|..||.|.| | ..  |. |.... |..    || .| |.   |.  .|||. |.. . .... .. || | |.
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1079-1132 1.5e-07 25.1 In-house 35-88 (440) alignment 
Range on Protein: 1079-1132
Range on HMM: 35-88/440.0
RKMTTNTAVSPANVGKNRYTNILPYDRTRVKLSPVDDEEGSDYINSNYIPGFTS
    .. |  | |  |||| ||| ||..|| |  |     |||||. || |  |
lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1134-1209 1.9e-07 24.9 In-house 137-206 (244) alignment 
Range on Protein: 1134-1209
Range on HMM: 137-206/244.0
REYIACQGPLPGTTDDMWRMIWEQNVTTVVMVTQlVEKGkvkcDQYWPDDHMPVLY-GDIQVTMnqTFEENDWNIKE
 |||  | ||  |. |.|.|. |. |  .|..   ||.     |.||||      |  || ||.  |  ..  ||| 
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeeditvtl..tdrdefknika
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1142-1263 3.1e-07 24.2 In-house 82-228 (302) alignment 
Range on Protein: 1142-1263
Range on HMM: 82-228/302.0
PLP-----------------GTTDDMWRMIWEQNVTTVVMVTQLVEKGKVKCDQYWPDDHMPVL-YGDIQ-------VTMNQTFEENDWniKEFAVQLR-
|.                   |..  | .| . ||. || ....||... || .|. |.   .| .|            ...  . ..   | ..|... 
pmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksf..klytveikn

-----DQRRYVRHWNFLSWPDHGVPESSQALLAFIRRIRSTKppssAPVAVHC
     .... |    | .||||| |. ... |  ..   | |      | |||
ekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesyk....knvlvhc