Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PTPRB_pd | Subfamily PTPRB | 39-325 | 4.3e-138 | 454.3 | In-house | 4-287 (293) | alignment | ||
Range on Protein: 39-325
Range on HMM: 4-287/293.0
SRPVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQATNAeVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGP
|.|. | ..|.|.. .||||..|..|||....|||. ...|..| ||..|||...||||.||||||.|||..|..||||||||||.|||||.||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaela.vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP
LPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKP
||||..|.|||.|||||.||||.|..||.|| ||..|||... .... |...|.|..| ..|.|..|.....|.|..|.| |..|||||||||||.||.
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade..epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektkt
MLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
.||||..|||.|.... .|..||||||||||||.||||||.|..|..|.||..|.|.|.|..||.|||||.||||||.|..|.. .
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 40-326 | 9.7e-115 | 379.3 | In-house | 3-284 (564) | alignment | ||
Range on Protein: 40-326
Range on HMM: 3-284/564.0
RPVLLANIETHYDWLKADSEHRLMEEYDDIQAVgSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPL
.|. |....|. |||.|. ...||| .|. . .....| |...|| |||...|..|.||||.| ...|....|||||..| |......||| ||||
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaa.nkpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl
PETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTK
.||..| |||.||..|..|||.||..| ||.|||.|||.| | . || |.|.|.|..| .... . ||| |. |.. .||| | .|||||||||||...
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesat
PMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
..||....||. .. .|..||||||||||||.|..| . . ..... ||. ..| ..| .||..||||.||||||. .... .|
slLdlirkvraln..epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 45-327 | 8.1e-100 | 328.9 | In-house | 5-284 (318) | alignment | ||
Range on Protein: 45-327
Range on HMM: 5-284/318.0
ANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTN
..|.| |... | | |||. .. . . | .. . .|||.|||.. ||.|.|.|||| |.|. ..||||||||.|... ..|||.|.||||| .
edleshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie
DMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKM--KREVIQLQFTSWPDHGVPEQTKPMLDF
|.|||.||..|..|||.|...| ||.|.|.|||.|. | .| |.| | |..|....... |.| ...... .|.| | ..|||||.||||.. .||.
DfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsy.gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl
VKNVrERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSGV
|..| ... .|. .|..|||||||||||..||.| | ...... ||| ..| ..| .|| .|||| ||.||.| |... ||
vrqv.skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 44-321 | 6.4e-97 | 319.1 | In-house | 6-277 (288) | alignment | ||
Range on Protein: 44-321
Range on HMM: 6-277/288.0
LANIeTHYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETT
. .. .. .|... . |||. . |... . ..|.. ||..|||.. ||||.. |||| |. ....|||||.|| | .. ..||| ||||..|
ispv.akvakksarnrtgfseeynsLaalekt.ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtv
NDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
|| |....|.|.. |||.|. ||||| ||..|||... . | ||..| |... . |....|...|.|.| ..|. |.|...||||||||...|.|...
ndfWelvyenktstivmltelveggktkCeeYWPdad.kpkny.GsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllell
KNVRERIRNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
..| .. .|.|||||||||||||.|||| | ...| .|..||.|.|...|..|. ||||..||.||...|..
rqvkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 48-324 | 7.6e-95 | 313.0 | In-house | 30-300 (308) | alignment | ||
Range on Protein: 48-324
Range on HMM: 30-300/308.0
ETHYDWLKADSEHRLMEEYDDIQAVGSiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLmalkgKSETDYINANYIPGF--NSPREYIACQGPLPETTND
. .. . ||.. ..|.||. ....| .. ... . ||.|||. ||||.|||||| ....|||||.|..|. ..||..||.|||||.|..|
dllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntved
MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
|||.|| ....|||.||.|| |. ||.|||| . |.. .. | . | | || ......||..|.. .. |.| ....|.|||||||......|||.
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfl
KNVRERIRNkcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
. ||..... .|..||||||||||||.|||| | ...| . |||...|. .|..|.. |||. ||.|....|..|.
elvrkslpg....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 43-323 | 1.3e-94 | 312.2 | In-house | 6-286 (288) | alignment | ||
Range on Protein: 43-323
Range on HMM: 6-286/288.0
LLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPET
. ... .. .|.|.. ..|.||....... . |.. . |..|||. ||||.|||||| |.| ...|||||.||.|.|..|..||.|||||.|
sveellklvlkllangltglleefeellsllpdlt.lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt
TNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWPDHGVPEQT
..| |||.||.....|||.||.|| |. ||.|||| | | ||| . | | || ......||.... ... .|.|.....|.|||||||. .
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp
KPMLDFVKNVRERIRnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
...|||.. ||. .. .||.||||||||||||.|||| | ...| . |||...|. .|..|...|||. ||.|....|..|.
ellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 48-323 | 2.6e-94 | 310.4 | In-house | 3-276 (281) | alignment | ||
Range on Protein: 48-323
Range on HMM: 3-276/281.0
ETHYDWLKADSEHRLMEEYDDIQAVGsIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMW
..| . |...... ..|||....|.| . .|..|. |..|||.. | |...|||. . ...|||||||..||.....||||.|||.|.. ...|
rkhlkqlsqndnaGfieeyeklaaig.vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW
RMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGGSLEVSLQSELDYEHWITRTFML-QKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNV
.|.||.| ..|||.|. .|.|| |||.||| .. |.. | . |. ..| . ...|.|.|.| ... .||| ||..|.|||||||..|| .|.| |.|
qmvweqkvsaivmvtreieagklkChrYWPddn..selkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkev
RERIRNKCViKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.. ..| |...|||||||||||||||||| ...|.. .||. || |.| .||..||| .|| |.. ..|..
lkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 62-324 | 7.4e-93 | 306.3 | In-house | 2-275 (284) | alignment | ||
Range on Protein: 62-324
Range on HMM: 2-275/284.0
LMEEYDDIQAVGSIVR-MDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGF-----NSPREYIACQGPLPETTNDMWRMIWEKK
|.||. .. . . ..... |..|||. ||||.|||||| |.|. ...|||||.|..|. ......||.|||||.|..| |||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn
STIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIR
...|||.|..|| |. ||.|||| . | . |||. . | | || ......||..|.. .. |.|.....|||||||||......|.|.. ||| ..
vrvIVmltelvengrekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle
NKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDND---FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
| .|..||||||||||||.|||| | ...| .. |||...|. .|..|.. |||. ||.|....|..|.
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 47-323 | 6.1e-90 | 297.0 | In-house | 5-276 (317) | alignment | ||
Range on Protein: 47-323
Range on HMM: 5-276/317.0
IETHYDWLKADSEHRLMEEYDDIQAVGSIvrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
.. .. .|.. . ..|.||. |.. . . .. ..|| |||. ||||.|||||| |.| ..|||||.|..|.| .|..||.|||||.|..|
lllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF
WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||.|| ..|.|||.|...| |. ||.|||| | . || | . | |.|| ..... ||.... ... .|.| ....|.|||||||. ....|||..
wrmvweqgvtvivmLteleelgrekcaqYwpl..getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle
NVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
||| .... .||.||||||||||||.||.... ...| . .||| .|.|.|..|.. |||. ||.|..|.|..|.
avrealedpg..gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 46-325 | 7.1e-90 | 296.8 | In-house | 5-289 (563) | alignment | ||
Range on Protein: 46-325
Range on HMM: 5-289/563.0
NIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMD-QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSET-DYINANYIPGFNSPREYIACQGPLPETT
. . | |.||..... ||....| .| ...... || ||| .|..|..||||| | || .. |||||||| |.. ...|| ||||..|.
efakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtf
NDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--------MKREVIQLQFTSWPDHGVPEQ
.| ||||||....||||.|. || |. ||..|||| | ||| .|.| |..| .||..... | ...|.| ..|.||||||||.
ddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetyg.alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh
TKPMLDFVKnvRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
. | | ||| .. || . |..||||||||||||||.|| |.. ..... |.| |.. .|..||.||||| ||||.|| |.. |
slpvLifvk..kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 53-323 | 9e-90 | 296.1 | In-house | 5-272 (273) | alignment | ||
Range on Protein: 53-323
Range on HMM: 5-272/273.0
WLKADSEHRLMEEYDDIQAVGSiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|.||..... . . .... . ||.|||. ||||.|||||| | ...|||||.|..|.|..|..||.|||||.|..| |||.||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe
KKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI
.....|||.|..|| |. ||.|||| . | .. | . | | || ......||..|.. .. .|.|.....|.|||||||......|.|.. ||. .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal
RN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.. . .||.||||||||||||.|||| | ...| . |||. .|. .|..| . |||. ||.|....|..|.
ealpsn...gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 53-323 | 3.2e-89 | 294.4 | In-house | 6-277 (297) | alignment | ||
Range on Protein: 53-323
Range on HMM: 6-277/297.0
WLKADSEHRLMEEYDDIQAVGSIVRMDQATNAeVNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|..|..... . . .. | . |..|||. ||||.|.|||| .....|||||.|..|.. .|..||.|||||.|..| |||.||
lekllflalllkefeellpllllgslsvallp.enleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe
KKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELD--YEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE
..|.|||.|. || |. ||.|||| ..| | || | . | |.|. ......||. ... |. .|.| ....|.|||||||| ....|||.. ||.
qnvtvIvmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk
RIRN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHME---DNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.... . .||.|||||||||.||.||.| . | .| . ||.. .|...|..|. |||. ||.|....|....
vlkllpsg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 45-323 | 6e-89 | 293.7 | In-house | 17-289 (297) | alignment | ||
Range on Protein: 45-323
Range on HMM: 17-289/297.0
ANIETHYDWLKADSEHRLMEEYDDIQAVGSivRmDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGFNS-PREYIACQGPLPET
.. .. ..||.| ..|..|. ... . .. ..||.|||. ||||.|||||| ..| ..|||||.|..|.. .|..||.|||||||
svldlllllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet
TNDMWRMIWEKKSTIIVMMTKTVEGGKdKCHQYWPKKKGrsdtYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDF
..| |||.|| ..|.|||.||.|| |. ||.|||| . | . | . | | .. ......||. ...|. |.| ..|.|.|||||||. .. .|.|
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllef
VKNVRERIR---NKcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.. |||... .. .||.||||||||||||.||.... ...| . ||| .|.|.|..|.. |||. ||.|..|.|....
lelvrealaelpkg...gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 41-324 | 3.2e-88 | 290.8 | In-house | 4-284 (319) | alignment | ||
Range on Protein: 41-324
Range on HMM: 4-284/319.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNaEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.. ........ |.. .|. | .|. ... .. .|.|.. | ||.|||.. ||.|...||.|..|.|. ..|||||..| |.. ...|| |.||
eievqeLkerlkalastgetllekefkllkeavnd.tfdsask.eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle
ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGrsdTYGGSLEVSLQSELDYEHWITRTFMLQK--NKM-KREVIQLQFTSWPDHGVPEQTK
.|..|.|||.||..| |.||.|| || .| |...|||... . .| | | |..| |..| | ..|.| ... ||| . |.|.||||.|||...
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenf...eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat
PMLDFVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
.||..|..|. |.| .|..||||||||||||.|.|| .... . .|| .| ..|. || .||.. ||.||.. |...
slldllkrirks.rektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 42-323 | 9e-88 | 290.2 | In-house | 9-304 (307) | alignment | ||
Range on Protein: 42-323
Range on HMM: 9-304/307.0
VLLANIETHYDWLKADSEHRLMEEYDDIQAVGSI-VRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYI--------PGFNSPRE
. . ... .. |..|. ..| .|. ... | . . ... ..||.|||. ||||.|.||||. |.|. ...|||||.|. .|....|.
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk
YIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQ---KNKMKREVIQLQFTSWP
.||.||||||| .| |||.||...|.|||.|..|| |. ||.|||| . | . ||| . | | || ..... ||. .. .... |.|.....|.||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp
DHGVPEQTKPMLDFVKNVRERIRN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|||||. ....|||.. ||. ... . .||.||||||||||||.||.. . ...|.. ||. .|...|..| ||.. ||.|....|...
dhgvppsfeelldfieevrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
F
.
l
|
|||||||||
DSPc_SM00195 | 64-323 | 7.4e-87 | 286.4 | In-house | 4-262 (263) | alignment | |||
Range on Protein: 64-323
Range on HMM: 4-262/263.0
EEYDDIQAVGSIVrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
||...... | . .. . ||.|||...||||.|.|||| ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte
TVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcvIKPVI
.| || ||..|||...|.. |.| ...| |... .. ..|.||. |.|.. .|.| |.|...|||||||..||..|.... |... ... .|..
eeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv
VHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
||||||||||||....| . ...|... ||.. .|.|.|..| .|||..||.||......|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
PTPc_SM00194 | 64-323 | 7.4e-87 | 286.4 | In-house | 4-262 (263) | alignment | |||
Range on Protein: 64-323
Range on HMM: 4-262/263.0
EEYDDIQAVGSIVrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
||...... | . .. . ||.|||...||||.|.|||| ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte
TVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcvIKPVI
.| || ||..|||...|.. |.| ...| |... .. ..|.||. |.|.. .|.| |.|...|||||||..||..|.... |... ... .|..
eeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv
VHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
||||||||||||....| . ...|... ||.. .|.|.|..| .|||..||.||......|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 46-323 | 1.2e-86 | 285.9 | In-house | 6-277 (278) | alignment | ||
Range on Protein: 46-323
Range on HMM: 6-277/278.0
NIETHYDWLKADSEHRLMEEYDDIQAVGSivRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTND
... .. .|.... ..|..|. ... . . .. . ||.|||. ||||.|||||| |.| .|||||.|..|.| ||..||.|||||||..|
dllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved
MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPkkkGRSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
|||.|| ..|.|||.|. || |. ||.|||| | | || | . | |..| ......||. . ... .|.| ......||||||||.....|||.
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggslty.gdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl
KNVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
| |||..... .||.||||||||||||.|||..| ...|.. .||.. .|.|.|..| |||. ||.|....|..|.
kavrealedsn..gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 49-326 | 2.2e-84 | 278.2 | In-house | 16-293 (298) | alignment | ||
Range on Protein: 49-326
Range on HMM: 16-293/298.0
THYDWLKADSEHRLMEEYDDIQAVGSIVRMD--QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
. |. . .. .|. ...| | .. . ...... || |||. .|.....||| | . ... |.||||| .. ... .||.|.||.||..|
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF
WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||..|.... |||.|...| .| |.|.|||... ..||| ...|||.|. .. |.|.....|.| .||| ||.||||||.||||... .||...
WrmvteedigtiVmltnleeldktkyhkywPdeg..ketyg.eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr
NVRErIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
.|| .... |||||.|||||||.||.||.| . .... . ||| || .|..| .||||.||.||.. .... |.
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 35-326 | 6.3e-84 | 276.7 | In-house | 7-298 (330) | alignment | ||
Range on Protein: 35-326
Range on HMM: 7-298/330.0
KNRVSRPVLLANIETHYDWLKADSEHRLMEEYDDIQAvGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIA
|. |. . ..| . .|| ... ||.. . | |.| .... | || |||. .||||..||| | ..|. |.||||| .| |.. ..||
gnkkyfplpvekleeeirirsaddnklfreefnalPa.gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfia
CQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYGgSLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWP
.|||. || .|.||||||.||. |||.|. | ..||.||||.. | . ||| . |... | ... | |..| ..| .| | |. |||||
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyG.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP
DHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
| ||| ... ||...|.|.. |. |..||||||||||||.|.|| . . .. . ||| ..| ..|. | .|||. || ||. |..|. |
dvGvPfepiGmlkllkkvkkl..nqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 87-320 | 4.1e-83 | 273.8 | Pfam-A | 1-234 (235) | alignment | ||
Range on Protein: 87-320
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
||.|||...||||...|||| ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....| |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt
YGGsLEVSLQ-SEL-DYEHWITRTFMLQKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLT
|| ..| |. .| | .....|.. |.|.| . ||| ||..|.||||||||..|..||....|... . .||.||||||||||||..||| |
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill
QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 87-320 | 4.1e-83 | 273.8 | In-house | 1-234 (235) | alignment | ||
Range on Protein: 87-320
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
||.|||...||||...|||| ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....| |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt
YGGsLEVSLQ-SEL-DYEHWITRTFMLQKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLT
|| ..| |. .| | .....|.. |.|.| . ||| ||..|.||||||||..|..||....|... . .||.||||||||||||..||| |
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill
QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 41-326 | 6.4e-83 | 273.4 | In-house | 3-286 (305) | alignment | ||
Range on Protein: 41-326
Range on HMM: 3-286/305.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDqatNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.. |...... ...|.. | ..|. .. .. . .. . |.||.|||...| .....|..| . . . ..|||||.|. |... .||. ||||.
iialddlaayikearvysdkgleaqykslyeeeesidvg...kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk
ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTK
.| .| ||.|.| | . |||.||.||||||||.||||..|... . |...| |.|| .. .|.| . . . .| .| |.|.|.|.|||||||...
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat
PMLDFVKNVRERIrNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
.|...|.|... .| .|..|||||||||||..||.| .... . ||| .|. ..| .| ..||| || |.|| | .. .|
sllslikrvqkdq.kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 57-325 | 1.2e-81 | 268.8 | In-house | 5-279 (290) | alignment | ||
Range on Protein: 57-325
Range on HMM: 5-279/290.0
DSEHRLMEEYDDIQAVGSIVRMDQ-----ATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIW
..|... .|. ..... . .... |...|.|..|||. ||||..|||.| ... . ||||||.| | ... |||| |||||.| .| |||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw
EKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI
||. .|.||. . || || ||..|||...... ..| ..||.|..| . .. ||. ....| .|.| |...|.|||||||...|..|.....|||.
eknveivvmaCrevelgkkkCerYWpeegeeelefg.efevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelq
RNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
... .|..|||||||||||| ||.| . .... .|| .| |.| .|. ||||. || ... ........
ese..daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 83-323 | 3.2e-80 | 264.6 | In-house | 7-246 (249) | alignment | ||
Range on Protein: 83-323
Range on HMM: 7-246/249.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. ..|| |||. ||||.|||||| |.| .|||||.||.|....|..||.|||||||..| |||.|| ..|.|||.|..|| |. ||.|||| |
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg
SDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN---KcviKPVIVHCSAGVGRTGTYIALD
| .| | . | | |. ......||..|. ... .|.| ..|.|.|||||||. ....|||.. ||. ... . .||.||||||||||||.||..
sley.gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkg...gpvlVHCsaGvgRtGtfiaay
RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. ...| . ||. .|...|..|.. ||.. ||.|....|....
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 83-323 | 5.5e-80 | 264.0 | In-house | 29-272 (278) | alignment | ||
Range on Protein: 83-323
Range on HMM: 29-272/278.0
NAEVNKTKNRFNKILPYEHSRVKlmalkgksetDYINANYIPGFnsPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. . |. |||. ||||.||||| |||||.||.|. |...||.|||||.|..| |||.|| ..|.|||.|. ||.|. ||.|||| |
lylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..gg
SDTYgGSLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWPDHGVPEQT--KPMLDFVKNVRERIR--------------NKcviKPVI
| || | ..| |.|| ......||.... .. ..|.| .|....|||||||... |..|.... .||... .. .||.
slty.gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg...gpvl
VHCSAGVGRTGTYIALDRLTQHMedNDFVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLMDYF
||||||||||||..|.. . ... .. ||. .|.|.|..|.. ||.. ||.|....|....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 83-323 | 2.6e-79 | 261.4 | In-house | 5-243 (245) | alignment | ||
Range on Protein: 83-323
Range on HMM: 5-243/245.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. ..||.|||. ||||.|.||||. .| .|||||.|..|.. .. .||.|||||||..| |||.|| ..|.|||.|...| |. ||.|||| |
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge
SDTYGGsLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIR--NKcviKPVIVHCSAGVGRTGTYIALDR
| |||. . | | || ......||.... ... .||||......|||||||. .. .|||.. ||. .. .. .||.||||||||||||.||...
sltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsn...gpvlVHCsaGvgRtGtfiaayl
LTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. ...| . |.. .| |.|..| |||. ||.|....|....
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 60-322 | 2.9e-79 | 261.2 | In-house | 26-296 (306) | alignment | ||
Range on Protein: 60-322
Range on HMM: 26-296/306.0
HRLMEEYDDIQAVGSIVRMDQA-TNAEVNKTKNRFNKILPYEHSRVKLMaLKGKSETDYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKST
..||....| . .... .. ||.|||.. |||..|.||.| .. ...|||||||| .| ..||| || |..| .| |||.|...|.
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr
IIVMMTKTVEGGKDKCHQYWPKKKGRSDtYgGSLEVSLQSELDYEHWITRTFMLQ---KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNK
.|||.|| || ||.|| .|||... ... | |...|. || . ...| |..... |.| .|||.|..|.||||||||.... .|||...|... ..
vivmttkevErgkekCarYWPdeeekee.y.GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel
C--VIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|..||||||.|||||.| .| |.. .| . . .|. .| .| .|. |||||.|| |.. . |
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 42-324 | 3e-79 | 261.3 | In-house | 4-287 (307) | alignment | ||
Range on Protein: 42-324
Range on HMM: 4-287/307.0
VLLANIETHYDWLKADSEHRLMEEYDDIQAVgSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPE
. . ..|. . | |... |..||. ..| | . .... . |. |||...| .... |||| ..|| ..|||||..| |.. ...|| |.|. .
iaiddleealksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea
TTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK-------MKREVIQLQFTSWPDHGVPE
| .| ||||.|...|.|||... | ..||..|||. || .. | | || ...| |.. . |.| .|.|.| ..|.|.| |||
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe
QTKPMLDFVKNVRERIRNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
... .|.....||| ... |..|||||||||.|...||| | |... .| ||.. .|...| .|| ||| ||.|.. |.||
vargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 47-323 | 4.3e-79 | 260.6 | In-house | 3-290 (297) | alignment | ||
Range on Protein: 47-323
Range on HMM: 3-290/297.0
IETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDqATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
|| ...|. .. |..|| .|.. ... |.. .| .|||.. .| |...||.| .......||||||.. |.. .. .|| ||||..|..|
ieelvayvkekgkrGlskeyaeirnepveGtfl.asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf
WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||.||.. .|||.|..|| |. || ||||.... |. .| .|.|| . .|.. .|.. .. |.. .|.|. ||.||||.|||.... .||...
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg.dlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle
NVRER-----------IRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.|||. . .. |..||||||.|||||.|.|| ...|. . |||. .| .| | . .||. || | . ....|
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 64-322 | 1.3e-77 | 255.5 | In-house | 19-274 (280) | alignment | ||
Range on Protein: 64-322
Range on HMM: 19-274/280.0
EEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYI----PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
... . . ...| .| | .|||. ||||.. |||| .||||||||||. |. . |||.||||..|..|.|.|.||.||..||
aqfeqlyrkkpglaisaarkpe.nlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv
MMTKTVEGGKDKCHQYWPKKKGrSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRnKCVIK
|.| .|| |. |||||||... . .|| ...| ...| . ...| ..|.... .|...|||...|||||||.... .|.||..||. | . .
mlttlverGrvkChqyWPeted.eleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.r.sgkee
PVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
||.||||||.|||| .|.|. . .| .. | . .| .|| | ||||..|| |. ....
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 40-326 | 2.7e-77 | 254.8 | In-house | 4-282 (315) | alignment | ||
Range on Protein: 40-326
Range on HMM: 4-282/315.0
RPVLLANIETHYDWLKADSEHRLMEEYDDIQAvGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPL
.|. | .. |. || .. . ..|. | | . .| | . | || |||. .|..|..|||.| |. ....||.|||.|.|.| .| |||.|||.
qpipldqlityvaqkkastkngfkqdyesipg.gqlhpldvakkie.nkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn
PETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgrSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPM
... .|.||...|.. . |||.|..||| | |. .||| | .| | . |...|| .... ||. .. |||.||..||||| |||. | |.
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviy.Gkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytipl
LDFVKNVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
......|. |. ...||||||||||||.|.|| . ...| .. .|| .. .| | .||. || ||.| |.. | |
mnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 62-323 | 4.6e-76 | 251.0 | In-house | 20-276 (515) | alignment | ||
Range on Protein: 62-323
Range on HMM: 20-276/515.0
LMEEYDDIQavGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
. ||. |. | . . .. |.| .|||.. ||||. .|||| .. . . ||.|| |||.|.. . ||| |||.. ...|.||...... | |.|.
fseefhdlp..gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv
TKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRNKCViKPVIV
|| || | || .|||.| | | .| |..|.| | | |.. . |.. | | | .|| |||.|||..|. .| ..|.|. ... |.|.
tklkegdkikcgkyWPdkpgdsvkfG.sikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkad.hgqyt.hplii
HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|||||||||| .|..| |... . ||| .| .| .| |||||. || ||.. .....
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 82-323 | 7.1e-76 | 249.9 | In-house | 23-268 (274) | alignment | ||
Range on Protein: 82-323
Range on HMM: 23-268/274.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSE-TDYINANYIPGFNS-PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
.. ..||||...||| |.||| | . ....| ..||||||| |.. . |.| |||||.| .|.||||.......|||.|| | ..||..|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda
KGR--SDTYGGsLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRER-IRNKCVIKPVIVHCSAGVGRTGTYIAL
.. |..||. .|. .. .. ... |...|.. . .|.|. .|.|||| .|......||.|..|.| ... . ||.||||||.|||| .||
edyeiserygd.veikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai
DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. ...... .||| ..||..|..| .|||. || .|| |. |
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 57-322 | 1.5e-75 | 249.4 | In-house | 31-290 (319) | alignment | ||
Range on Protein: 57-322
Range on HMM: 31-290/319.0
DSEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKST
| .| |. . .| . .| . || |||. .||......||| | |. .||||| .. |. .. |||.||||..| .|.|||||| ...
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs
IIVMMTktveggKDKCHQYWPKKKgrsDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNK
||..| |||| ||||.| . . .|...| . . .. | . | . .| .|.. | | |||.|||... ... .||.|| . .
tivllt......kdkcsqywplki...vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske
CVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
....|||||||||||.||.|| | . |.... ||| .| ..| || ||| .|| ||. |..
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 63-320 | 2.3e-75 | 248.4 | In-house | 14-266 (273) | alignment | ||
Range on Protein: 63-320
Range on HMM: 14-266/273.0
MEEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMALKGksetdYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVM
||..... . .. . ... ..| ||.|||. ..|||...|||| . | ||||..| . ||||||||||||..|.|.|.||.|...|.|
aeefkelrelkpldtcevgkkke.nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam
MTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKM--KREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRnkcVIKP
.|. .|.|| |||.|||..|... . . |||.| ... . |........ ||| .|.|..||||||| .....| ||..||. . |
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagP
VIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..||||||.||.||.|..| . . .| . .|| .| ..| |. .|||. ||||.. ..
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 84-323 | 4.1e-75 | 247.2 | In-house | 6-242 (250) | alignment | ||
Range on Protein: 84-323
Range on HMM: 6-242/250.0
AEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDkCHQYWPKKKgrS
|| |||. .|.....||| | || |.||||| .. |.. . .|| ||||..|..|.|||..|.||. |||.|. .| .| .||||| .| .
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..a
DTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKRE--VIQLQFTSWPDHGVPEQTKPMLDFVKNVReRIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ
..|| .. ||| |. . ...|...| |.| . | | ||.|..||| ||||... .|...|.|. . .... .||||.|||||||.|..||.| . .
ekyG.dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq.asqqqagnaPvivqCsaGvgrsGafiaidavle
HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
... . ||| |. .| .| |....||.|.. .. .
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 83-323 | 2.6e-74 | 245.1 | In-house | 6-242 (243) | alignment | ||
Range on Protein: 83-323
Range on HMM: 6-242/243.0
NAEVNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIPGFnsPReYIACQGPLPETTND----MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPk
. ..|..|||. ||||.|||||| . .||||||.|... || .||.|||||||..| |||.|| ..|.|||.|..|| |. ||.||||
llpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.
kkgrSDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN---------KcviKPVIVHCSAG
.... | ..| | || ..... ||..|. .. .|.||......|||||||. ....|||.. ||| |.. . .||.||||||
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg...gpvlVHCsaG
VGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLMDYF
||||||.||.. . ... . ||. .|...|..|.. |||. ||.|....|. ..
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 80-322 | 5.8e-74 | 244.1 | In-house | 18-254 (284) | alignment | ||
Range on Protein: 80-322
Range on HMM: 18-254/284.0
QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTktveggKDKCHQYWPKK
. .| . || |||. .||......||| | |. .||||| .| |. .. |||.||||..| .|.|||||| ... ||..| |||| ||||.|
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk
KgrsDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIAL
. . .|...| . | .. | . | . .| .|.. | | |||.|||... ... .||.|| . . ....|||||||||||.||.|
i...vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl
DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
| | . |.... ||| .| ..| || ||| .|| ||. |..
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 50-324 | 2.8e-73 | 241.5 | In-house | 12-279 (314) | alignment | ||
Range on Protein: 50-324
Range on HMM: 12-279/314.0
HYDWLKADSEHRLMEEYDDIQAVgsivrMDQaTNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRM
. ||. . . |||. . | .. . |..|||...||.|..|||.|....| ...|||||..| ... |...|. ||||.||..|.||.
siallkraegygfkeeyeslfeg.....wda.akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl
IWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgrSDTYGgSLEVSLQSELDYEHWITRTFMLQK----NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKN
....... |||.|. || |. || .|||.. ...|| ..| | . . ..|.| ..| . .||| |.||..||||.|| . . .|..|..
vydencasivmltelvevgrvkClkyWPed...tevyg.dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr
VRERIRNkcVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD-YFC
| . . ...|||||| |||||.||.| . . .| .. ||| .| ..| .. .|.|| ||.||.| ... .|
vkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 78-323 | 8.7e-73 | 239.9 | In-house | 35-277 (315) | alignment | ||
Range on Protein: 78-323
Range on HMM: 35-277/315.0
MDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWP
... ..| .|||.. |||....|||| . . . ||||| ||..... . ||| ||||. . .|.|||....| | |||.|| || | || ||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP
KKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALD
..|. | .| |..|.| | ..| ....| . .| | | ||| |||.||..|| .| ..|.|. |. ...||||||||||| |..|
drkadsvefG.sikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisid
RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
....... ||| .| ..| .| |||||| .| ||.| .....
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 83-322 | 3.5e-70 | 231.1 | In-house | 16-263 (270) | alignment | ||
Range on Protein: 83-322
Range on HMM: 16-263/270.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKG
.| .|. ||.. ||| ..||.| |. .|.| ||||||..||. ....||| .|||| |... ||||||.|.| |||.|. .| |..|| .|||....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk
R-SDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTK------PMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYI
. .. | ..| .|| | .|.. |... .|... ....|||||||... .| ...||. ... .|..|||||||||||| |
ekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli
ALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
||| .. .| . ||| .. |.| .| |||. || |.. .. |
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 44-327 | 1.2e-69 | 230.0 | In-house | 7-292 (325) | alignment | ||
Range on Protein: 44-327
Range on HMM: 7-292/325.0
LANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETT
. |. | . ||. . . |.. . ....| . ... || ||||. ......||| | ..| ....|||||.|. . ..|.| ||..|.
vvnlvehvekkkaqdqdgfahefgllpsddgiak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati
NDMWRMIWEKKSTiIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGsLEVSLQSELDYEHWITRTFMLQKNKMK--REVIQLQFTSWPDHGVPEQT---KP
||.||.. . ... .|... ...|||.| .||||. | | |.|| |||.|.. .. .. | . ... | | | |.|. ||.| ||... .
ndlWrlvldWrcs.vvvvlneldlgkdrcavywpkemgksktfGg.levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis
MLDFVKNVRERIRN-KCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSGV
.|. ||.| ||.. |..|||||||||||..|.| . ... .. ||. |.| .| .| .|.| |||.|...|.... ||
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 59-323 | 7.2e-67 | 220.5 | In-house | 22-296 (300) | alignment | ||
Range on Protein: 59-323
Range on HMM: 22-296/300.0
EHRLMEEYDDIQAVGSIVRMdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKsETDYINANYIPGF--NSPREYIACQGPLPETTNDMWRMIWEKKST
| .. ||. |. . .... ..|. ||||...||||..||.|.. | . .|.|||| | . |.||..||||. | .|.|.|.||.. .
egkvfteyeripkkredall.staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq
IIVMMTKTVEGGKDKCHQYWPKKKGR--SDTYgGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNV---RER
.|||.|.. |.||.|...|.||.. . . .. | .|. . | . ||... |. | .|.|. ||.| |||||||| |..|.....| |..
livmlteeeedgkeksfkyfPkleskkktvef.gkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk
IRNKC----VIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.. . ||.||||||||||| | | |.. .| |. .|. |. .| | .|||| .|| |... |. |.
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 71-325 | 7.3e-67 | 220.6 | In-house | 35-286 (297) | alignment | ||
Range on Protein: 71-325
Range on HMM: 35-286/297.0
AVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKd
. .. . .. || |.|.. ||||. ||||| . . . ||.|| ...|.. ..|. | | ..| .|.|.|..... ..|||... |. |
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.
KCHQYWPKKKGRSdtyGGSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPE--QTKPMLDFVKNVRERIRNKCVIkPVIVHCSAG
|| .||..| . |.. | |.| . | | |.. ..|.| ..| | | ||..|||. |.. ... .|.....||. .. |..|||.||
kcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaG
VGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
||||| ....| ...... ||. |.| .| .| |||||. || |.. ..... |
vGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 79-324 | 6.1e-66 | 217.2 | In-house | 38-284 (290) | alignment | ||
Range on Protein: 79-324
Range on HMM: 38-284/290.0
DQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSE--TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYW
. ... ||..|||..|..|. |. | . |. . .|||| || |.. ..||| |||...| | |..||..|.|||||.|. .| ||.||.|||
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW
PKKkgRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKM---KREVIQLQFTSWPDHG-VPEQtKPMLDFVKNvRERIRNKCVIKPVIVHCSAGVGRTGT
|.. ...| | .. |..| ... |.|.. ..... |..|.|.|.|.|...| |... . .| ... ..... | ....||||..|||...
pds..dtkay.gefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp.qtillviee.myktqrkrgntsivvHCSdtvgrsav
YIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
..|.. .... . .|| |. ..|. . .|||. || .|.. .. |.
fcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 87-320 | 9.5e-66 | 216.4 | In-house | 3-236 (237) | alignment | ||
Range on Protein: 87-320
Range on HMM: 3-236/237.0
NKTKNRFNKILPYEHSRVKLMALKgkSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgRSDT
|| |||. .| |.|||| | |..|||||.|. ||. .|..|||.|||| . .|.|.|.|..| ..|||.| .|| . |||.|||. . . .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa
YGgSLEVSLQSELDYEHWITRTFMLQKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQH
|| | |||. . .. . |...|.|. ..|| | |||||||.|||.|| .| | ||. .| . | |.|||||||||| .. .| . ..
yg.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq
MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
... ||. | . | |..||. ||.|||. ..
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 57-320 | 1.5e-65 | 215.9 | In-house | 18-277 (288) | alignment | ||
Range on Protein: 57-320
Range on HMM: 18-277/288.0
DSEHRLMEEYDDIQavgsiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKS
| .....|...| . | . |... .|||.. ||||.|.|||| .|. ||||| .. . . ..|| |.||..| || |.|..|.||
dkkfkeleqkqdke.....arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks
TIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGsLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE---RI
.|||... | || |...|||..||.. ..| |.|.|.|. . |... |.. |. .. ...| ||.||||..|||. . .|.|...|..
sviVmllskeelgkpkvdrYwPedkgetvkfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav
RNKCVIkPVIVHCSAGVGRTGTYIALDRLTQH-MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..|. . |..|||||||||||.. . . ..| .|. || .| | . ||...|. | . .
qrkskt.PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 83-325 | 5.6e-62 | 204.3 | In-house | 43-280 (287) | alignment | ||
Range on Protein: 83-325
Range on HMM: 43-280/287.0
NAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGr
|. || |||...||... || | . . ||||| .| |... ...|....|. .| ..|..|.... |.|||... | ...|.||||..|
iasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.
sdTYGGSLEVSLQSELDYEHWITRTFMLQKN---KMKREVIQLQFTSWPDHG-VPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDR
.. | ...| .| ....| |.. .... . |..| | |.|.|...| |.|. .| . . .... | ...||||..|||.....| .
..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq..rkrgntsivvhCsdtvGrsamfcaaat
LTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
.. . . .|| |. ..|. . ||| .||.|| | .. | |
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 64-316 | 9.9e-61 | 200.0 | In-house | 10-264 (290) | alignment | ||
Range on Protein: 64-316
Range on HMM: 10-264/290.0
EEYDDIQAVGSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
| | ||. | ... .| . . |...||. . ||.|||.|| ....|||||. . . |.|| |||||.|.. .|.|.||.|| .||. |
eiyldirkeasdfptrea.klpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk
TVEGGKDKCHQYWPKKKGRSDTYG--GSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPV
|| .. ||.||||... . .|.| | || ...... |.. |.. . ||... .|.||| |||| .|.|. .||| . |.
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa
IVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIH
..|||||.||.||.. .| . ..|..| ||. |..|.| .| |.|| | | .
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 74-323 | 1.4e-60 | 199.5 | In-house | 26-277 (287) | alignment | ||
Range on Protein: 74-323
Range on HMM: 26-277/287.0
SIVRMDQATNaEVNKTKNRFNKILPYEHSRVkLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCH
| . . .|.. . |||. ..||....|| |.. .|. .|||||||..... ..||.|||.. | .|.||...|..|. ...||. || .. ||.
statfkaaee.laavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy
QYWPKKkGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKR--EVIQLQFTSWPDHGVPEQTKPMLDFVKNV---RERIRNKCVIKPVIVHCSAGVG
.|||.. . || | |. . .. .|.. | . . . | ||.. ||||.... . .. || .| | |. . |..||...|.|
kywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG
RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|.|...|. | . .|| ||| || .|..|. |||. |. .. . |. |.
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 48-322 | 4.4e-58 | 191.8 | In-house | 8-278 (439) | alignment | ||
Range on Protein: 48-322
Range on HMM: 8-278/439.0
ETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQATNA-EVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
. | . |. . . . |... |... . . . | | ..||||.... ...|.|| | . | . ||||||| |. .. |||.||| |||.|.
qehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf
WRMIWEKKSTIIVMMTKTVEGGKdkchqYWPKKkgrSDTYGGSLEVSLQSELDYEHWITRTFMLQ----KNKMKREVIQLQFTSWPDHGVPEQTKPMLDF
||...|||.. |||.|. || | ||| . .... | . | . ... ... | | . ... .| |.|.....|||. || |. .|||
wrlviekktvtivmltnlvesyk.....ywpsd...aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf
VKNVRErIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
.. . .| . ||.|||||||||||| |||| ... .. ||. |.| .| .|. .||. ||.||......
lrains.andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 85-325 | 1.3e-57 | 189.7 | In-house | 40-292 (296) | alignment | ||
Range on Protein: 85-325
Range on HMM: 40-292/296.0
EVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKdKCHQYWPKKKgrSD
. |. ||| |..||.. || | |.|....||||| |. .| ..||| ..| || .. ||....... .|..||| . | ....|||.|
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..ke
TYGgSLEVSLQSELDYEHWITRTFMLQKN------K------MKREVIQLQFTSWPD-HGVPEQTKPMLDFVKNVRER---IRNKCVIKPVIVHCSAGVG
|| ..| . .| | . .||| |.|. . .| | ..|.| |. . || |. ...... || . .. . .||.|..| |..
qyg.eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas
RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
|.| |.|.| . .| .. ||| . | .| .|. ||.. ..| .| | | ...
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 58-320 | 2.2e-57 | 189.0 | In-house | 27-289 (297) | alignment | ||
Range on Protein: 58-320
Range on HMM: 27-289/297.0
SEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPRE--YIACQGPLPETTNDMWRMIWEKKS
..|| .|.. . | . . ....|| | .||| ...|||.|||||| . ....||||| | . ||. |||.||||..| |.|.|.||. .
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGv
TIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYGgSLEVSLQSEL-DYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN
..||..|. | | .|..|||.. | |..|. || | || . .. |.| |. ... | | |. | |||..||| ..|..|.| . | |
vvivnltrleeegvkqckrywpde.G.sevyh.iyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG
KCVikPVIVHCSAGVGRTGTYIALDRLTQHMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
.. |..||||.|.||||.||..| . ... .|.. . .| |. ||.|. |. |. ..
rsc..pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 62-320 | 7.8e-57 | 187.4 | In-house | 22-233 (392) | alignment | ||
Range on Protein: 62-320
Range on HMM: 22-233/392.0
LMEEYDDIQavGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
..||. |. | . ..... |.|. |||...||||. .|||| . ...||.|| |||.|.. . |||.||| . . .|.|||..... | |.|.
ffeefhdlp..gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv
TKTVEGGkdkchqywpkkkgrsdtyggslevslqseldyehwitrtfmlqKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIV
|| || | . .| | | .|| |||..||..| .| |.|.|. .|.|.
tklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf..Gqythplii
HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
|||||||||| |..| . | . .||| .| ..| .| |.|||. || ||. ...
hcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 81-319 | 1e-56 | 186.8 | In-house | 2-237 (239) | alignment | ||
Range on Protein: 81-319
Range on HMM: 2-237/239.0
ATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
|.. |||.|||. .|. |.|||| | | .|||||.|. .. ||. ||| || . .. |.|||.|... .|||.| .|| | |||||||
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds
KGRsdtYgGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALD
. | | |.|. . .| |||.. . .| | | .|| |||.|||. . .| . ... . . .| ..||||||||||... .|
tsk...y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvid
RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
. .. . . ||. | .| | ..||| ||.||| ..
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 83-319 | 1.4e-56 | 186.3 | In-house | 3-236 (239) | alignment | ||
Range on Protein: 83-319
Range on HMM: 3-236/239.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKG
. |||.|||. .|. |.|||| | | .|||||.|. .. ||. ||| || . .. |.|||.|... .|||.| .|| | |||||||
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts
RsdtYgGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDRL
. | | |.|. . .| |||.. . .| | | .|| |||.|||. . .| . ... . . .| ..||||||||||... .| .
k...y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidam
TQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
.. . . ||. | .| | ..||| ||.||| ..
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 75-321 | 1.2e-53 | 176.8 | In-house | 21-264 (283) | alignment | ||
Range on Protein: 75-321
Range on HMM: 21-264/283.0
IVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGksetDYINANYIP---GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDK
. . . |. ||.|||...|.|.. ||.| .. ||||| .|| . ..||..|.|| .| |.|.|....| | |||.|| |. . |
pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik
CHQYWPKKkGrSDTYgGSLEVSLQSELDYEHWITRTFMLQKN---KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREriRNKCVIKPVIVHCSAGVG
| |||||. | | | | . |.|. | . .| . ..|..| | . . |. | . | .. | | . ... |..||||.|.|
CsqyWPkr.G.sedy.GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvisl..qteskkgPivvhCstgiG
RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
||...||. ... . ||| || || .| .||| || ..|. ..
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 115-325 | 4.1e-53 | 176.1 | In-house | 4-227 (272) | alignment | ||
Range on Protein: 115-325
Range on HMM: 4-227/272.0
TDYINANYIPGFNS---PREYIACQGPLPETTNDMWRMiWEKKSTIIVMMTKTVEGGKDKCHQYWP---------KKKGRSDTYGGSLEVSLQSELDYEH
..||||....|... |. .....|||| | .| ||. .| . . ||......| |..||..||| . . | | | |.|| ...
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld
WITRTFMLQ---KNKMKREVIQLQFTSWPDHGVPEQTkpMLDFVKNVRErirnkcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVD--------V
.| |...| .... ||| .|..|.|||||||... .|.... ... .||.||||||..||||..||..| . ..... || .
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl
CGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
..| |.| .| . ||||.||.|....|.....|
eeaveelraqrpgavqteeqylflyeallellrs
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 61-323 | 1.7e-52 | 173.0 | In-house | 16-293 (301) | alignment | ||
Range on Protein: 61-323
Range on HMM: 16-293/301.0
RLMEEYDDIQAVGSivRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKG--KSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTII
.. |.|.... . . . . . | ||. |||..| .|.. |. | . .....||||.|| |... ...|| |||. .| |.||.||..| . |
kfeeqykelkeged..ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi
VMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELDYE-----------------HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLD
||.|.. || |.||.||||. . .|... | ..| |..| | | |.| ...| ..|.||| |.||..|| . . .|
vmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq
FVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. .| | ..| ||.||||..|.|.|.|.... . ||| .|. .| . |.| ||..|.| . |.
viddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 87-324 | 5.3e-52 | 171.4 | In-house | 1-172 (182) | alignment | ||
Range on Protein: 87-324
Range on HMM: 1-172/182.0
NKTKNRFNKILPYEHSRvklmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTktveggkdkCHQYWPkkkgrsdty
|..|||. .||||.||| ||||||.. | ....||.||||..|..|..||..| . |.||..| ...|||
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........
ggslevslqseldyehwitrtfmlqkNKMKREVIQLQFTSWPDHGVPEqTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIALDRLTQHmedn
.. .|..||.....|||||||. . .|||.. |.| .||.||||||||||||..|.. . ..
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....
dFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
|.. .|...|..|. |.|. ||.|....|....
.gvsleeavklvrsrRpgmvitpnqyfflqlallelll
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 82-324 | 2.3e-49 | 163.0 | In-house | 35-278 (307) | alignment | ||
Range on Protein: 82-324
Range on HMM: 35-278/307.0
TN-AEVNKTKNRFNKILPYEHSRVkLMALKGKSeTDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKK
.. . | |||.. . ...|. .. ..| . .||| |||. |. .|..|||| .| ..| |. ..| ..|. |..| .| ||.|||| ..
veafsantdknryqdvkcqdkgri.vvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee
GRSDTYGGSLEVSLQSEL------DYEHWIT-RTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnkcviKPVIVHCSAGVGRTGTY
|. ..| . . ..| |. | |. .. . | . .||.. |||.|||. ..... || ||.|||||||||.||
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt......npvvvhcsaGvGrsGti
IALDRLTQHM-EDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
.|. . . | . . |. .| |.| .|.| .||| ||...| |..||
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 115-317 | 9.5e-49 | 160.7 | In-house | 2-164 (174) | alignment | ||
Range on Protein: 115-317
Range on HMM: 2-164/174.0
TDYINANYIPGFNSPREYIACQGPLPettndMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkgrsdtyggslevslqseldyehwitrtfmlQKNK
.|||||... .. ....||.||||. |.|..| ..|..||... .| |. ||..||| ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred
MKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVRERIRNkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEdNDFVDVCGVVCEMRMHRNYLVQTETQYIF
..|..||.... |||||||. .. .|.||| |.| . . . .||.|||||||||||| .|.... .... ...||.. .| |.|..| . |||. ||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
IHD
...
lyy
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 60-275 | 2.9e-46 | 153.0 | In-house | 27-248 (418) | alignment | ||
Range on Protein: 60-275
Range on HMM: 27-248/418.0
HRLMEEyddiqAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
||.|| .|| . . | .|||. .||| .|.||.| .. | .|||||||| | |...|. |||||.| |.|||.||.. |||
frllee.....svgpset..segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriiv
MMTKTVEGGKDKCHQYWPKKKGRS--DTYGGSLEVS------LQSE-LDYE-HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRER
|... | . || .|||.. | || || | | | ||| | . |.. | |. |||| .|..|.|. ...... .|
mlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr
I----RNKCVIKPVIVHCSAGVGRTGTYIA
. |.|||||||||||||. .
qnqiipssdrnvpiivhcsagvgrtgtfct
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 84-322 | 5.7e-46 | 151.5 | In-house | 53-282 (290) | alignment | ||
Range on Protein: 84-322
Range on HMM: 53-282/290.0
AEVNKTKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPreYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRS
.. . .|||. . . .|| || . ||. |||. | ... .| ||.| .|. |.|||. ..| . |||. . .| || ||.||.|.|.|.
kntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev
DTYGGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIALDRLTQ
|.| . ... . .. | .|. ... . . |. ||||. |. | .| .. .|. . ||.||||||.|||||..|.. |
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglq
HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
. | .|. ..| .| | || ..||. . . |.|.
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 57-324 | 6e-46 | 151.5 | In-house | 27-290 (305) | alignment | ||
Range on Protein: 57-324
Range on HMM: 27-290/305.0
DSEHRLMEEYDDIQAVGSIVRMDQAtnAEVNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKS
| | . | . .. .|. |....||||.. . ..| ||| . | .||| |||. | . .|..|||| .| ...| |. ..|
reefrglakytrpdmtqvafnanqs..adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv
TIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLE---VSLQS--ELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREri
|||. |||| || || |||| .| . . . || | | | || . . | | .||.| ||| ||| |... .|
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg..
rnKCVikPVIVHCSAGVGRTGTYIALDRLTQHMEDND-FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
| |..||||||.||||| .|.. . ... .| . .| .| .| . .|.. ||.||| ...||
..skv..pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 113-316 | 5.9e-45 | 148.4 | In-house | 3-154 (172) | alignment | ||
Range on Protein: 113-316
Range on HMM: 3-154/172.0
SETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTveggkdkchqywpkkkgrsdtyggslevslqseldyehwitrtfMLQK
. .|||||.|... |...||.||||..|..| |||..|.. |.||..|. .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp
NKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVRE--RIRNKcviKPVIVHCSAGVGRTGTYIALDRLTQHMedndfvDVCGVVCEMRMHRNYLVQTET
. .|..||.....||||||| .. .|.|.. ..| .... .||.|||||||||||| .|.. . ... .. .|...|..|.. ||..
ellerlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnps
QYIFIH
||.|..
qyrfly
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 57-322 | 2e-43 | 143.3 | In-house | 3-258 (267) | alignment | ||
Range on Protein: 57-322
Range on HMM: 3-258/267.0
DSEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKST
|.| . .|.. |. . .. || |. .||... |||...|| | ..| .|||| |. |.. . .|. |.|| | | . .| ..| .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp
IIVMMTKTvegGKDKCHQYWPKKKGRSDTYGG-SLEVSLQSELDYEHWITRTFMlQKNKMKREVIQLQFTSWpdhGVPEQTKPMLDFVKNVRERIRNKCV
.||..||. ..|. ...|| | |.. | ..| ||. | . . || . ||. ..| . | . . || | . . . . .
vivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw...nintnnkpylkplfgilaknqleng
IKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
.|..|.||.||||.||.. .| . . .. .|. . ..| | ||.| .||.||. | .|
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 115-322 | 7.1e-43 | 141.7 | In-house | 12-172 (176) | alignment | ||
Range on Protein: 115-322
Range on HMM: 12-172/176.0
TDYINANYIPGFnsprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDtyggslevslqseldyehwitrtfmlqknk
||||||.| | .||.|||||.|. | ..|..| . |..|..|. || |. ||..||| .. .
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................
mkreviQLQFTSWPDHGVPEQtKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDrltqHMEDNDFVDVCGVVCEMRMHRN-YLVQTETQYI
| ... |||||||. . .|.... .||..... .||.||||||.|||||..|.. .| . ...| .....|..| . |||. ||
......qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr
FIHDCLMDY
|...... .
flyefelll
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 81-322 | 6.5e-42 | 138.1 | In-house | 31-268 (281) | alignment | ||
Range on Protein: 81-322
Range on HMM: 31-268/281.0
ATNAEVNKTKNRFNKILPYEHSRVKLMA-LKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
. | ||. |||. .| . |||.| . | |||| |||| | || ||| || |.|||||....| |||. . .| ..|| .|.|..
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn
KGRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnkcviKPVIVHCSAGVGRTGTYIALDRL
. | || . . .| . | . | . . . ||| ||| .. || ....| | | ..||||||||.|| .|..
ahcclqf.dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars......tppvihcsagvgrsgtlmaveia
TQHMED-NDFVDVCGVVCEMRM-HRNYLVQTETQYIFIHDCLMDY
| . . |. .| .|. | ||| ||..| |.|.
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 83-322 | 3.3e-41 | 137.4 | In-house | 42-279 (314) | alignment | ||
Range on Protein: 83-322
Range on HMM: 42-279/314.0
NAEVNKTKNRFNKILPYEhSRVKLMALKGKSeTDYINANYIPGFnspREYIACQGPLPETTNDM----------WRMI--WEKKSTIIVM----------
. ..|..|||. .|||.. .||.| | ... .|||||.|. || . .||.||||..| .| |||. .. .. .|||
dlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel
-----------MTKTVEGGkdkchqywpkkkgrsdtyggslevSLQSELDYEHWItrTFMLQKNKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVRER
.. ..| .. .. |.|.. . . ... .|..|.. . .||...| .. ...|.. ..|
srLdaAlgKtpllildgng........................neptaadlellk..eelydpelferlgikylripvpDgsap.lledfdeflefieea
irnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRN-----YLVQTETQYIFIHDCLMDY
.||.|||.||.|||||..... | .. . |.. .. ..|. | .... ||.||...|..|
....dkggpvlvHCkaGkgRtgtfvvaaylmkll...g.vsleealedvrlkRpinpnpgfieqleqyefilealley
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 64-323 | 1.1e-40 | 134.4 | In-house | 23-271 (288) | alignment | ||
Range on Protein: 64-323
Range on HMM: 23-271/288.0
EEYDDIQAVGSIvrmDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
|| | .|| | ... | |..|.... . .|||| ||.|| .. . .| | .| || | . .|.|. |. |||...
keyrdspneasi...diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce
TVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREV--IQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIV
.| ||.| .|.| |.|.. .| | .. | .. .. . . ..... .| .| . |.|.||||. .. | ... . | . ||..|
llekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivv
HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|.||||||||| | . . .||. . .. ..| .| .||| ||...| |.....
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 122-317 | 1.1e-40 | 134.1 | In-house | 1-144 (152) | alignment | ||
Range on Protein: 122-317
Range on HMM: 1-144/152.0
YIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWpkkkgrsdtyggslevslqseldyehwitrtfmlqknkmkreviQ
.|.|.. |.|.||.|||.|.|..| |||..| . |.|||.|. .| ||.||.||. |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q
LQFTSWPDHGVPEQTKPMLDFVKNVRE-RIRNKCvikPVIVHCSAGVGRTGTYIALDRLTqhmednDFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
... |||||||. . .|.... ... ...... ||.||||||||||||..|.. . |.. .| .|..|.. |... |..|...
ylhlpwpDhgvpdlsqlllflllfieklaldkgg...pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 82-324 | 2.5e-40 | 133.2 | In-house | 30-271 (285) | alignment | ||
Range on Protein: 82-324
Range on HMM: 30-271/285.0
TNAEVNKTKNRFNKILPYEHSRVKLmalKgKSETDYINANYI--PGFNSpREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
| | | ||. . | .|| | | . . ||| |... || . ||. ||||||| .|.|.||...| . ..|. .||| .|| |.|.|
tayeanpdlnryadvrcieetrvvl...k.nhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek
KGRSDTYGgSLEVSLQSE----LDYEHWITRTFMlQKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVRErIRNKcvIKPVIVHCSAGVGRTGT
| .| |..| . . . | . . . | ..| |||. ||...||... | |.. . | ||. |||||||||| |
lgevvkfg.kyeitlteckeeaiagtilnaltvi.ntedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpk..ekpicvhcsagvgrtat
YIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
.. .| | .. .| ... .| ||| | ||. |..|.. ||.||
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 78-243 | 1e-38 | 127.9 | In-house | 22-190 (297) | alignment | ||
Range on Protein: 78-243
Range on HMM: 22-190/297.0
MDQATNAEVNKT--KNRFNKILPYEHSRVKLmaLKGKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCH
.. . | | . |||...|| .. .|||| |.. .|.|||||.|. | ... || |||| .| .| |....|. .|||..| |.|.|||
gesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca
QYWPKKKGRSDTYGGSL-EVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
|||. .. . | . | . .... | . | . .| | || |||||||| . . . |
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 62-324 | 1.4e-38 | 127.4 | In-house | 24-288 (305) | alignment | ||
Range on Protein: 62-324
Range on HMM: 24-288/305.0
LMEEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
| .|. .. . . .| .|. .. |||. . .. |||| .| .|| |||. |. .| .| || .| |.| | ...| | |.
lraefvamkrfndfekmkafkeaq.eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml
TKTVEGGKDKCHQYWPKKKGRSDTY---GGSLEVSLQSEL------DYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERi
. .| | ||..|.. |.. .. | . | ..| | . .|.| .. . .| | . . ||| ||| .|..... |
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.
rnKcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFV-DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
| |..||||||.||||. . |. . . . . . | .. .| || .||..||.|.|. ...||
..k...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 98-320 | 1.5e-37 | 124.3 | In-house | 1-168 (178) | alignment | ||
Range on Protein: 98-320
Range on HMM: 1-168/178.0
PYEHSRVKLMALKGKSETDYINANYIPGFnsprEYIACQGPlpettNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGrsdtyggslevslqse
|....||.|. | | .|||||..| .. |.....| | .....| . | ||..|...|.|. ||..|||.. |
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................
ldyehwitrtfmlqknkmkrevIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI-RNKcviKPVIVHCSAGVGRTGTYIALDRLTQHmedndFVDVCGVVC
|| ... .||||||. .. .|.||. ..| . ... .||.|||||||||.|| .|.. . .. ... ..
......................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie
EMRMHRNyLVQTETQYIFIHDCLM
..|..|. |... |. ..... .
lvrerRp.ivpnpgqlrqLyefel
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 115-319 | 1.2e-36 | 120.9 | In-house | 3-149 (151) | alignment | ||
Range on Protein: 115-319
Range on HMM: 3-149/151.0
TDYINANYIPGFnspreYIACQGPLPettnDMWRMIWEKKSTIIVMMTKTVEGGkdKCHQYWPKKKgrsdtyggslevslqseldyehwitrtfmlqknk
.||||..|. |. .....|||. | .....| . . ||......| | .|..|.|.
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................
mkREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcV-IKPVIVHCSAGVGRTGTYIALDRLTQHmedndfVDVCGVVCEMRMHRNYLVQTETQYI
.||.......|||.|.|. .. .|.|.. ... .||.||||||.||||| .||... .. |.. .. |.|..| ..||...|..
..ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl
FIHDCL
|.. .|
fqlfal
|
|||||||||
PTPc_DSPc_SM00012 | 219-320 | 5.7e-35 | 115.1 | In-house | 2-104 (105) | alignment | |||
Range on Protein: 219-320
Range on HMM: 2-104/105.0
VIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
| ....|.||||||||.....|.....|.. ... |||.||||||||||||..||| | |..|.. ..||.. .|.|.|..|. .||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
CLM
.|.
all
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 62-251 | 1.4e-34 | 114.2 | In-house | 7-195 (319) | alignment | ||
Range on Protein: 62-251
Range on HMM: 7-195/319.0
LMEEYDDIQavGSIVRMDqaTNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVM
..||..|. | | | | |.|. ...| ..|| | . .. |..|.|. |.. .| |||.| .| ... |.||..||..| .||
vaeefrdlP..qliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq
MTKTVEGGKDKCHQYWPKKKGRSDT-YGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFtSWPDHGVPEQTKPMLDFVKNVRERIR
.|. | | ..| .|.| |.. .| | . |.|. ..... |..|.. ... ||. . |.. .|| . .... . .||. ..
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
|
|||||||||
subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 87-322 | 3.8e-34 | 112.6 | In-house | 52-289 (310) | alignment | ||
Range on Protein: 87-322
Range on HMM: 52-289/310.0
NKTKNRFNKILPYEHSRVKLMALKGKSEtDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkKGRSDTY
. |||. .. . ||||| | . | ||| |||. .| .|||| | |.||||..... |... |..| |. || ||| | ..||
ymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtety
GgSLEVSLQSELDYEHWI---TRTFMLQK-------NKM-KREVIQLQFTSWPDHGVPEQTkpmldfVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIA
| . |. || | | . ||. .. .. . | ... ||| |||.. .. | .|. . |..||||||..|... .|
g.cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvrhgpcvvhcsagkdrlyvvva
LDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|. .... . ||. |. |.. .| .||| ||..|. . .
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
|
|||||||||
subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 82-314 | 7.4e-34 | 111.8 | In-house | 45-272 (301) | alignment | ||
Range on Protein: 82-314
Range on HMM: 45-272/301.0
TNAEVNKTKNRFNKIlPY-EHSRVKLMAlKGKSEtdYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKK
..| ..| |.|.... | .. |.... .|| | ||.|| |. .|| ||||..|..|.| |. . |||....|| ..||..| | |
syaylpkdkhryptv.PckPstaveviv.dGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki
GRSDTYG-GSLEVSLQSELDYEHWITRTFMLQKNK---MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIAL
... | .... . . .. . ||. .. | |. |...|.|.|||. . |... |.. ||..||||||.||. ..|.
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiGrsvafigt
DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
. |....| . ... . ..| || |||..| .
eylareveadptieltealkhlrehrwngvqtnsqlyw
|
|||||||||
subfamily_egg_pd | Subfamily egg | 80-323 | 9.6e-31 | 101.6 | In-house | 34-270 (307) | alignment | ||
Range on Protein: 80-323
Range on HMM: 34-270/307.0
QATNaEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGgkDKCHQYWPKK
.| . . |..| | ... . ||||| .|. |.| ||.. | |.| .| || .| .|.|||..... |||.| ..| ..|. ||||
taas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka
KGRSDTY-GGSLEVS---LQSELDYEHWITRTFMLQKNkmkREVIQLQFTSWPDHGVPEQTKPMldfvkNVRERIRNkcVIKPVIVHCSAGVGRTGTYIA
. | . |||.. ..|. | .|. .. . .| |. . . . . |. .| ..|| . |||.|.. || ...| .|
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdvnnssdvyspl.....rvlrklrn..lskpvvvqdilGvskaatlva
LDRLTQHMEDNDF--VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.. .. | | .|..|.. |.. .|.|.. .. .|
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
|
|||||||||
subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 64-325 | 1.2e-29 | 98.0 | In-house | 23-278 (312) | alignment | ||
Range on Protein: 64-325
Range on HMM: 23-278/312.0
EEYddiQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkGkSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
|| .||| || . | | ||. .| .. | | | | || ||.. | ....|||| .|. .|.. || |....
key...kavgnivsdsectaflkfkdlnrypniqcwdrgrftla...g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg
TVEGGKDKCHQYWPKKKGRSD--------TYGGSLEVSLQSELDYEHWITRTFMlQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirNKcv
|| | .|| .| | | | .|. .| | . . . . . . . |..||||||.|. | .. |. .|
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvv.katgqesklnhyqwaswpdhgmpdscdtalrllsavkk...dk..
iKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
|||| ||||||||||| . .. . . .| . .| | |.. ||.. |..... |
.kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 87-179 | 5e-27 | 89.5 | In-house | 47-153 (350) | alignment | ||
Range on Protein: 87-179
Range on HMM: 47-153/350.0
NKTKNRFNKILPYEHSRVKLM-AL-------KGKSETDYINANYIP------GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKC
.|||.. ||||||||||| .| . | |||||||. |. ||| |.|||.| .|....| . | ..|...|. || . .||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc
HQYWPKK
..||..
yrYWqeg
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 185-322 | 7.6e-27 | 89.2 | In-house | 11-142 (145) | alignment | ||
Range on Protein: 185-322
Range on HMM: 11-142/145.0
TYGGSLEVSLQSELDYEHWITR--TFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDRLTQh
| ||| . |. || .. ||. ... .. .|..||.....|||||||. .. .|.|.. ..| .... .||.||||||||||||..|.. . .
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll.
medNDfVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
.. |.. .. ..|..| . |... |..|...... .
...lg.vsleealelvrsqrpgavpnpgqlrflyefelel
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 193-317 | 1e-25 | 85.5 | In-house | 23-139 (144) | alignment | ||
Range on Protein: 193-317
Range on HMM: 23-139/144.0
SLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDRLTqhmeDNDfVDVC
| .|. ..|. | .. ..||.||.....|||||||. .. .|.|.. ..| .... .||.||||||||||||..|.... .. ...
ellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtgtlvaaylmk....klg.lsle
GVVCEMRMHRNYLVQTETQYIFIHD
.. ..|..| . |... |..|...
ealalvrsrrpgavpnpgqlrfLle
|
|||||||||
subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 138-319 | 9.4e-25 | 81.7 | In-house | 99-284 (302) | alignment | ||
Range on Protein: 138-319
Range on HMM: 99-284/302.0
PLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGG------SLEVSLQSELDYEHWITRTFMLQKN----KMKREVIQLQFTSW
| .|.. | .| . . .|.| ... ||... || .|. .| | ..| |.. |. | .. | .. . |.|. | |.|..|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw
PDHGVPEQTKPMLDFVKNVrErirnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
|||| |..... || .| | . | |.|||||||||||| .|. | .. |. .|. .| | ||.|.| |.. |.
pdhGapkeaytaldilkfc.e.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
|
|||||||||
subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 129-316 | 9.7e-24 | 78.6 | In-house | 4-197 (199) | alignment | ||
Range on Protein: 129-316
Range on HMM: 4-197/199.0
PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK----MKREVIQLQF
| |||.| || || |.|.|.|| | |||. . ||| . . || || |. .. . ...| .| ||. . ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqf
TSWPDHGVPEQTKpMLDFVKNVRERIRNKC--VIKPVIVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
||| .. |. . .. || || .. ||||||| | | || ..||| . | | ||. | .| | .. . .| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
|
|||||||||
subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 130-316 | 1e-23 | 78.6 | In-house | 4-196 (198) | alignment | ||
Range on Protein: 130-316
Range on HMM: 4-196/198.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK----MKREVIQLQFT
| |||.| || || |.|.|.|| | |||. . ||| . . || || |. .. . ...| .| ||. . |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqft
SWPDHGVPEQTKpMLDFVKNVRERIRNKC--VIKPVIVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
|| .. |. . .. || || .. ||||||| | | || ..||| . | | ||. | .| | .. . .| ||.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 215-324 | 1.1e-21 | 71.7 | In-house | 87-195 (440) | alignment | ||
Range on Protein: 215-324
Range on HMM: 87-195/440.0
MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
| . | .. .|||.|||. . |.| ....| | ..|. |..||||||.|||| ||.| . .. . .| .|. .. || | .||| || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf
IHDCLMDYFC
.|..... .
vheavlegll
|
|||||||||
subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 99-318 | 3.6e-21 | 70.6 | In-house | 30-254 (290) | alignment | ||
Range on Protein: 99-318
Range on HMM: 30-254/290.0
YEHSRVKLMALKGKSETDYINANYIPgFNSPREYIACQGPLPET-------TNDMWRMIWEKKSTIIVMMTKTVEGGKD----KCHQYWPKKKGRSDTYG
|..|| | . . ||| ||.. . . . |. | |. .. .. | |. . |.. .||. . | .. | .| |.. | . ...
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk
GsLEVSLQSELDYEHWITRTFMLQKNKMKR-EVIQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIVHCSAGVGRTGTYIALDRLTQHME-D
| |.|. .| . .||. ... .. . | .. .| . |.|.|| .|. ...| |. |||||| |. | . |.. | .
g.ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkv......kasktpvivHcvdGiSrsAalaaiilgyQkiaet
NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDC
.. | . |. ..| .|. ........ |.
sgsvkledvlkalrkqralaitsalelafvdag
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 87-178 | 5e-19 | 62.8 | In-house | 48-155 (349) | alignment | ||
Range on Protein: 87-178
Range on HMM: 48-155/349.0
NKTKNRFNKILPYEHSRVKLMA-LK-------------GKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKD
.|||...||||||||||| || . |||||||. . .. . ||| | ||| | .| ...| .. ... ... | . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle
KCHQYWPK
||..|| .
kcdiywqe
|
|||||||||
subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 86-321 | 1.9e-18 | 61.1 | In-house | 46-277 (303) | alignment | ||
Range on Protein: 86-321
Range on HMM: 46-277/303.0
VNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIpGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
| |||| .. .||.||| |.. || |.|. ..| . | | ||. |. |.|.|| |.| .... | | . .|... .
knmdknrfvdvicldhskvkl......sdssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf
YGGSLEVSLQSELD-YEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKP-MLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALD--RLTQ
|. | ... . | . . . . | . .. .|| .| .. | .. . ... .|. . .| . .|.||.||. .. |.
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl
HMEDNdFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
| |.. .|. .. .| | . || .|. ... | .
hseqa.sldlvkclenvrngrlhavqnlsqfsvvytllae
|
|||||||||
subfamily_eak_pd | Subfamily eak | 49-244 | 2e-17 | 57.6 | In-house | 18-205 (332) | alignment | ||
Range on Protein: 49-244
Range on HMM: 18-205/332.0
THYDWLKADSEHRLMEEYDDIQAVGSIVRMdQATNAeVNktKNrFNKILPYEHSRVKLMALKgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWR
. | . . .....|| | . || . ..| || .| ||.||.. |.| . . . . |||| . . |.|| . . .|.
knhiwnrinqrinivadlddyqrllsiset.arlea.vn..rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwq
MIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTkPMLDFVK
|. |.|| ||.. . || . .| .|.|.| .| | |.| .. . . || ..|.| .| .. | . .| .| . |
mvleqkspaivqlledvelkleksdkyfpdk.treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye.dflalrk
|
|||||||||
subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 142-322 | 9.7e-17 | 55.9 | In-house | 40-220 (255) | alignment | ||
Range on Protein: 142-322
Range on HMM: 40-220/255.0
TTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSelDYEHWITRTF----MLQKNKMKREVIQLQFTSWPDHGVPEQTK
| . ....| .|.. .||.. | |..||..|.| .| . ..|. . . || .| . | ..| ... |... ||...
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar
PMLDFVKNVRErirnKcviKPVIVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
.| .| ||. |.|.||||.|.||. ... . . | .. . | | .. |.| .|. ..| | | ..|.
eilnilkvvrd....s...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 218-323 | 2.3e-16 | 54.5 | In-house | 216-344 (350) | alignment | ||
Range on Protein: 218-323
Range on HMM: 216-344/350.0
EVIQLQFTSWPDHGV---PEQTKPMLD-----FVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ-----HMEDNDFV---------D-VCGV
.| |||. |.| .. ||. ..|. ... | .. .|..||||||||||||...|| | . .. .... | . .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii
VCEMRMHRNYLVQTETQYIFIHDCLMDYF
| |.| | .||. .|.|||...|. ||
vnelrkqrismvqnldqfifiYeallfyf
|
|||||||||
subfamily_hpo-7_pd | Subfamily hpo-7 | 141-323 | 5.4e-15 | 50.0 | In-house | 45-227 (263) | alignment | ||
Range on Protein: 141-323
Range on HMM: 45-227/263.0
ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDyeHWITRTFML----QKNKMKREVIQLQFTSWPDHGVPEQT
.| . ....| .|.. .||.. | |..|| .|.| .| . ..|. . . .| | .. | ..| . ... |... ||..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela
KPMLDFVKNVRErirnkCviKPVIVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. .| .| .|. |...||||.|.||. . . . | .. . | | .. |.| .|. ..| | | ..|..
reilnilkvarn.....s..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 247-322 | 9.5e-15 | 49.1 | In-house | 238-314 (319) | alignment | ||
Range on Protein: 247-322
Range on HMM: 238-314/319.0
RERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
| .. |..|||| ||||||. || | ...|.. ||. .| .| | |.| || ||. | |
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
|
|||||||||
subfamily_Sponge-PTP-7_pd | Subfamily Sponge-PTP-7 | 260-321 | 2.7e-14 | 47.3 | In-house | 2-63 (69) | alignment | ||
Range on Protein: 260-321
Range on HMM: 2-63/69.0
IVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
.||||.| |||||.||. . . .||. | || | .| | .|||||| |..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 78-231 | 1.3e-13 | 45.2 | In-house | 88-234 (244) | alignment | ||
Range on Protein: 78-231
Range on HMM: 88-234/244.0
MDQATNAeVNKTKNRFNKILPYEHSRVKLMalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKtVEggkdKCHQYWP
| .| | | ||| ||.. .|| | || |||| .. . ||| | || .|. |.|.|. |.. ..|.. || . .|||
mkdafnp.nnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.ve....eedeywp
KKKGrSDTYGGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHG
. . | . |.| .. . . .. |. .. . .| . || |
dsep.lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
|
|||||||||
subfamily_Sponge-PTP7_pd | Subfamily Sponge-PTP7 | 260-321 | 1.5e-13 | 44.9 | In-house | 1-62 (69) | alignment | ||
Range on Protein: 260-321
Range on HMM: 1-62/69.0
IVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
.||||.| |||||.||. . . .||. | || | .| | .|.|||| |..
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 217-323 | 4.7e-12 | 39.9 | In-house | 218-344 (349) | alignment | ||
Range on Protein: 217-323
Range on HMM: 218-344/349.0
REVIQLQFTSWPDHGVPEQTKPMLDFVKnVRE---------RIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ--HMEDNDFVDV----------CGVV
|..|||. |.| .. . .| .. |.. .. ...|||||| ||||... || | . .. |... . .|
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv
CEMRMHRNYLVQTETQYIFIHDCLMDYF
|.| | .|| .|.|.|...|. ||
nelrkqrismvqnlaqfiaiyealLkyf
|
|||||||||
subfamily_Sponge-PTP3_pd | Subfamily Sponge-PTP3 | 41-137 | 3.2e-11 | 37.2 | In-house | 4-95 (95) | alignment | ||
Range on Protein: 41-137
Range on HMM: 4-95/95.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPREYIACQG
|. .. . .| ....|.. . .|. |. . .| | |||| .|.||. .|| .| | ..||||| .. |. |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapy..tvgsseanipknrflnifpydatrv...vlttkrdsdyinacfvdgyarkncyiaaqg
|
|||||||||
subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 97-232 | 3.9e-11 | 37.4 | In-house | 3-126 (130) | alignment | ||
Range on Protein: 97-232
Range on HMM: 3-126/130.0
LPYEHSRVKlmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKtVEggkdKCHQYWPKKKgRSDTYGGSLEVSLQS
|..| ||.. . .||||... . .||. | || .|. |.|.|. |. ..|.. || . .||| . . | . |.|
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.ve....eedeywpdse.Plewyeediivtltd
ElDYEHWITRTFMLQKNKMKR---EVIQLQFTSWPDHGV
| . | ... ...... . .| . || |
r.defknikasnleiesdlneshqaltmfqisnwpsdgt
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 40-128 | 4.7e-11 | 36.7 | In-house | 4-88 (440) | alignment | ||
Range on Protein: 40-128
Range on HMM: 4-88/440.0
RPVLLANIethYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNS
||...|.. |... . | .|. . | . . .. || |||. .|| |.|||| | .|| ..||||| || | .|
rpiivadf...adyvqnnrrsrafedewsllpsgls.qpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 258-319 | 1.2e-10 | 35.8 | In-house | 230-291 (297) | alignment | ||
Range on Protein: 258-319
Range on HMM: 230-291/297.0
PVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
...|||||||||.| . | . . . . || .. .| | |||| |. ...|
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
|
|||||||||
subfamily_Sponge-PTP-2_pd | Subfamily Sponge-PTP-2 | 82-180 | 2.3e-10 | 33.7 | In-house | 22-88 (169) | alignment | ||
Range on Protein: 82-180
Range on HMM: 22-88/169.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtktveGGKDKCHQYWPKKK
.. .|.|||| | | |||| . . .||||| ||||| ...||.. |. | ..||.|.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwpeke
|
|||||||||
subfamily_Sponge-PTP2_pd | Subfamily Sponge-PTP2 | 82-180 | 2.9e-10 | 33.2 | In-house | 21-87 (169) | alignment | ||
Range on Protein: 82-180
Range on HMM: 21-87/169.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtktveGGKDKCHQYWPKKK
.. .|.|||| | | |||| . . .||||| ||||| ...||.. |. | ..||.|.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpeke
|
|||||||||
subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 87-170 | 4.8e-10 | 33.4 | In-house | 34-116 (332) | alignment | ||
Range on Protein: 87-170
Range on HMM: 34-116/332.0
NKTKNRFNKILPYEHSRVKLMALKGKSetDYINANYIPGFNSPREYIACQGPLPETTND-MWRMIWEKKSTIIVMMTKTVEGGKD
| || .. ..||||.| || |. ||... |.. || .| |. . |. .|||. |.| ..|... | |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
|
|||||||||
subfamily_PTPDC1_pd | Subfamily PTPDC1 | 208-317 | 9.4e-10 | 33.2 | In-house | 71-170 (182) | alignment | ||
Range on Protein: 208-317
Range on HMM: 71-170/182.0
FMLQKNKMKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVRERIRNKcvikPVIVHCSAGVGRTGTYIALDRLTQHMedndfVDVCGVVCEMRMHRNYLVQ
| ........ | .|.|.||. .. .|| || | .... | ||| || |||| || . .. .. . .| .| .|
fsYdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg....kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiq
TETQYIFIHD
| .| ....
treqvelvke
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 85-162 | 1.1e-09 | 32.2 | In-house | 35-117 (347) | alignment | ||
Range on Protein: 85-162
Range on HMM: 35-117/347.0
EVNKTKNRFNKILPYEHSRVKLMALKGKS-----ETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMT
| . .||| .. . .|| | | | |||| .| |. .||| | |||.| |.|.|. | | .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 224-323 | 1.4e-09 | 31.8 | In-house | 188-285 (302) | alignment | ||
Range on Protein: 224-323
Range on HMM: 188-285/302.0
FTSWPDHGVPEQTKPMLDFVKNVreRIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.| |... ||.. . ...| .. . ..... |.|| |. ..| ....... . . .| .| | |.. .||.... .|. |.
ltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
|
|||||||||
0038934 | (Phosphotyrosine protein) phosphatases II | 211-276 | 1.6e-09 | 33.2 | In-house | 71-135 (194) | alignment | ||
Range on Protein: 211-276
Range on HMM: 71-135/194.0
QKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrNKCVIKPVIVHCSAGVGRTGTYIAL
...... |. .||.|.. ... .|.|.. | | . |.. . | ||| ||.||||| .|
dpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaa
|
|||||||||
PTEN_1 | 216-301 | 6.2e-09 | 30.9 | In-house | 92-173 (196) | alignment | |||
Range on Protein: 216-301
Range on HMM: 92-173/196.0
KREVIQLQFtSWPDHGVPEQTKpMLDFVKNVRERIRNK-CvIKPVIVHCSAGVGRTGTYIAlDRLTQHMEdNDFVDVCGVVCEMRMH
|. |..|.| ...|||.| . ..|..|.. | .... . . |.||| ||.||.|| .| | ... .. . . |.|.|..
ksgveylhf.pieDhgapslse.lfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva.ayLmykgk.ltadeAlelvrekRpp
|
|||||||||
subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 171-322 | 1.6e-08 | 28.4 | In-house | 149-301 (332) | alignment | ||
Range on Protein: 171-322
Range on HMM: 149-301/332.0
KCHQYWPKKKGRSDTYGgsleVSLQSELDYEHWITRTF--MLQKNKMKREVIQLQFTSWPDHG-VPEQTKPMLDFVKN--VRERIRNKCVIKPVIVHCSA
|...||.|. . | .|.|. |. .|| . ..| .. . ..| | | .|| | .| .| . .| |... |..
icrkfwpekrskkdfpa....lsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat
GVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|| . . ..| . .. .. | . . ..|.| ..| | . || .
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 58-187 | 1.3e-07 | 25.3 | In-house | 24-149 (302) | alignment | ||
Range on Protein: 58-187
Range on HMM: 24-149/302.0
SEHRLMEEYDDIQAVGsiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMAlkgkSETDYINANY--IPGFNspREYIACQGPLPETT---NDMWRMIWE
. .. .|.. |... | ... . | ||. ... ... .||| | .. .|.|| .| .. |. | | | ... .. |||...
dtaevkkefkkidtmk..vdlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfq
KKSTIIVMMTKTVEGGKdKCHQYWPKKKGRSDTYG
.| . .|.. .. | | ....||| | .||
ekivsvvilvgeeelkk.tlselfpkksgdykeyg
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 82-126 | 1.7e-07 | 25.1 | In-house | 32-77 (244) | alignment | ||
Range on Protein: 82-126
Range on HMM: 32-77/244.0
TN--AEVNKTKNRFNKILPYEHSRVKLMALKgKSETDYINANYIPGF
|| .| ||||. .|||....|| | . | | .|||||||| |
tnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs
|
|||||||||
subfamily_PTEN_pd | Subfamily PTEN | 211-312 | 2.6e-06 | 22.5 | In-house | 74-169 (184) | alignment | ||
Range on Protein: 211-312
Range on HMM: 74-169/184.0
QKNKMKREVIQLQFTswpDHGVPeQTKPMLDFVKNVRERIRNKCvIKPVIVHCSAGVGRTGTYIALDrLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTET
...|.. .|....|. || | . . . ..|..... . .. . |.||| || ||||. |. | ... .. .. . |.|.. . |.
dskkfdgrvavypfd...Dhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPs
QY
|
qr
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 130-188 | 4.2e-06 | 20.3 | In-house | 236-290 (440) | alignment | ||
Range on Protein: 130-188
Range on HMM: 236-290/440.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEggkDKCHQYWPKKkGRSDTYGG
.|| | || | |.||.. . . . |.|. . . | ||| . || |.|
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvn.trsvtfgp
|
|||||||||
subfamily_VSP_pd | Subfamily VSP | 227-275 | 4.9e-06 | 20.6 | In-house | 101-147 (212) | alignment | ||
Range on Protein: 227-275
Range on HMM: 101-147/212.0
WPDHGVPEQtKPMLDFVKNVRERIRNKcVIKPVIVHCSAGVGRTGTYIA
|| ||. . .| | |.|.| . . . ...|| | ||||| .
iddhnvpkl.eellvftkevkewlekd.lknvlaihckGGkgrtGtivc
|
|||||||||
PTPc_motif_SM00404 | 193-275 | 7.4e-06 | 20.9 | In-house | 21-99 (140) | alignment | |||
Range on Protein: 193-275
Range on HMM: 21-99/140.0
SLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIVHCSAGVGRTGTYIA
|...|. .| | | . |.. .....|.. . .. . .|||..|. . . |.||| ||| |..| |.
allkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatlii
|