Gene PTPRB-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP068_AA protein Get Run
SpurP068_AA_44-324 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 39-325 4.3e-138 454.3 In-house 4-287 (293) alignment 
Range on Protein: 39-325
Range on HMM: 4-287/293.0
SRPVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQATNAeVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGP
|.|. | ..|.|.. .||||..|..|||....|||.   ...|..| ||..|||...||||.||||||.|||..|..||||||||||.|||||.||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaela.vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKP
||||..|.|||.|||||.||||.|..||.|| ||..|||...  .... |...|.|..| ..|.|..|.....|.|..|.| |..|||||||||||.||.
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade..epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektkt

MLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
.||||..|||.|....  .|..||||||||||||.||||||.|..|..|.||..|.|.|.|..||.|||||.||||||.|..|.. .
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPRD_pd Subfamily PTPRD 40-326 9.7e-115 379.3 In-house 3-284 (564) alignment 
Range on Protein: 40-326
Range on HMM: 3-284/564.0
RPVLLANIETHYDWLKADSEHRLMEEYDDIQAVgSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPL
.|.  |....|.  |||.|. ...||| .|.   . .....| |...|| |||...|..|.||||.| ...|....|||||..| |......||| ||||
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaa.nkpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTK
.||..| |||.||..|..|||.||..| ||.|||.|||.| | . || |.|.|.|..| .... . ||| |.  |.. .||| | .|||||||||||...
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesat

PMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
..||....||.    ..  .|..||||||||||||.|..| . . ..... ||. ..| ..| .||..||||.||||||. ....  .|
slLdlirkvraln..epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 45-327 8.1e-100 328.9 In-house 5-284 (318) alignment 
Range on Protein: 45-327
Range on HMM: 5-284/318.0
ANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTN
 ..|.|   |... |  | |||. .. . . |   .. . .|||.|||.. ||.|.|.||||  |.|. ..||||||||.|... ..|||.|.||||| .
edleshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKM--KREVIQLQFTSWPDHGVPEQTKPMLDF
|.|||.||..|..|||.|...| ||.|.|.|||.|.  | .| |.| | |..|....... |.| ......  .|.| | ..|||||.||||..  .||.
DfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsy.gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

VKNVrERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSGV
|..| ... .|.  .|..|||||||||||..||.| | ......  ||| ..| ..| .|| .|||| ||.||.| |...  || 
vrqv.skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 44-321 6.4e-97 319.1 In-house 6-277 (288) alignment 
Range on Protein: 44-321
Range on HMM: 6-277/288.0
LANIeTHYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETT
. .. ..    .|...  . |||. . |...  . ..|..  ||..|||.. ||||.. ||||  |. ....|||||.|| | .. ..||| ||||..| 
ispv.akvakksarnrtgfseeynsLaalekt.ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtv

NDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
|| |....|.|.. |||.|. ||||| ||..|||... .   | ||..| |... . |....|...|.|.| ..|. |.|...||||||||...|.|...
ndfWelvyenktstivmltelveggktkCeeYWPdad.kpkny.GsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllell

KNVRERIRNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
..|     ..   .|.|||||||||||||.|||| | ...| .|..||.|.|...|..|. ||||..||.||...|..
rqvkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0050432 (Phosphotyrosine protein) phosphatases II 48-324 7.6e-95 313.0 In-house 30-300 (308) alignment 
Range on Protein: 48-324
Range on HMM: 30-300/308.0
ETHYDWLKADSEHRLMEEYDDIQAVGSiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLmalkgKSETDYINANYIPGF--NSPREYIACQGPLPETTND
. .. . ||.. ..|.||. ....|   ..   ... . ||.|||.  ||||.||||||     ....|||||.|..|.  ..||..||.|||||.|..|
dllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntved

MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||.|| ....|||.||.|| |. ||.|||| . |.. .. | . | | ||  ......||..|..  ..  |.| ....|.|||||||......|||.
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfl

KNVRERIRNkcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
. ||.....    .|..||||||||||||.|||| | ...| .  |||...|. .|..|.. |||. ||.|....|..|. 
elvrkslpg....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0051299 (Phosphotyrosine protein) phosphatases II 43-323 1.3e-94 312.2 In-house 6-286 (288) alignment 
Range on Protein: 43-323
Range on HMM: 6-286/288.0
LLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPET
 . ... .. .|.|.. ..|.||.......   .    |.. . |..|||.  ||||.||||||  |.| ...|||||.||.|.|..|..||.|||||.|
sveellklvlkllangltglleefeellsllpdlt.lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

TNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWPDHGVPEQT
..| |||.||.....|||.||.|| |. ||.||||   | | |||  . | | ||  ......||....      ... .|.|.....|.|||||||. .
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

KPMLDFVKNVRERIRnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
...|||.. ||. ..     .||.||||||||||||.|||| | ...| .  |||...|. .|..|...|||. ||.|....|..|.
ellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 48-323 2.6e-94 310.4 In-house 3-276 (281) alignment 
Range on Protein: 48-323
Range on HMM: 3-276/281.0
ETHYDWLKADSEHRLMEEYDDIQAVGsIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMW
..| . |...... ..|||....|.| .    .|..|. |..|||.. |  |...|||.   . ...|||||||..||.....||||.|||.|.. ...|
rkhlkqlsqndnaGfieeyeklaaig.vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGGSLEVSLQSELDYEHWITRTFML-QKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNV
.|.||.| ..|||.|. .|.|| |||.||| ..  |..  | . |. ..| . ...|.|.|.| ...  .||| ||..|.|||||||..|| .|.| |.|
qmvweqkvsaivmvtreieagklkChrYWPddn..selkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkev

RERIRNKCViKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
..  ..|    |...|||||||||||||||||| ...|..   .||. || |.| .||..||| .|| |..  ..|..
lkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0046845 (Phosphotyrosine protein) phosphatases II 62-324 7.4e-93 306.3 In-house 2-275 (284) alignment 
Range on Protein: 62-324
Range on HMM: 2-275/284.0
LMEEYDDIQAVGSIVR-MDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGF-----NSPREYIACQGPLPETTNDMWRMIWEKK
|.||.  .. .   .     ..... |..|||.  ||||.||||||  |.|. ...|||||.|..|.     ......||.|||||.|..| |||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIR
...|||.|..|| |. ||.|||| . | . |||. . | | ||  ......||..|..   ..  |.|.....|||||||||......|.|.. ||| ..
vrvIVmltelvengrekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

NKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDND---FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
|    .|..||||||||||||.|||| | ...| ..    |||...|. .|..|.. |||. ||.|....|..|. 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0040438 (Phosphotyrosine protein) phosphatases II 47-323 6.1e-90 297.0 In-house 5-276 (317) alignment 
Range on Protein: 47-323
Range on HMM: 5-276/317.0
IETHYDWLKADSEHRLMEEYDDIQAVGSIvrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
.. .. .|.. . ..|.||. |.. .       . .. ..|| |||.  ||||.||||||  |.|  ..|||||.|..|.| .|..||.|||||.|..| 
lllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||.|| ..|.|||.|...| |. ||.||||   | . || | . | |.||  ..... ||....  ... .|.| ....|.|||||||. ....|||..
wrmvweqgvtvivmLteleelgrekcaqYwpl..getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

NVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
 ||| ....   .||.||||||||||||.||.... ...| . .|||  .|.|.|..|.. |||. ||.|..|.|..|.
avrealedpg..gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_PTPRG_pd Subfamily PTPRG 46-325 7.1e-90 296.8 In-house 5-289 (563) alignment 
Range on Protein: 46-325
Range on HMM: 5-289/563.0
NIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMD-QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSET-DYINANYIPGFNSPREYIACQGPLPETT
. . |   |.||..... ||....|       .| ...... || |||  .|..|..|||||  | || .. |||||||| |..  ...|| ||||..|.
efakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtf

NDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--------MKREVIQLQFTSWPDHGVPEQ
.| ||||||....||||.|. || |. ||..||||    | ||| .|.| |..|       .||..... |         ...|.| ..|.||||||||.
ddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetyg.alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

TKPMLDFVKnvRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
. | | |||  ..   ||  . |..||||||||||||||.|| |.. ..... |.| |..  .|..||.||||| ||||.|| |..   |
slpvLifvk..kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0047943 (Phosphotyrosine protein) phosphatases II 53-323 9e-90 296.1 In-house 5-272 (273) alignment 
Range on Protein: 53-323
Range on HMM: 5-272/273.0
WLKADSEHRLMEEYDDIQAVGSiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|.||..... .   .   .... . ||.|||.  ||||.||||||    | ...|||||.|..|.|..|..||.|||||.|..| |||.||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

KKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI
.....|||.|..|| |. ||.|||| . |   .. | . | | ||  ......||..|..  .. .|.|.....|.|||||||......|.|.. ||. .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

RN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
..   .   .||.||||||||||||.|||| | ...| .  |||. .|. .|..| . |||. ||.|....|..|.
ealpsn...gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 53-323 3.2e-89 294.4 In-house 6-277 (297) alignment 
Range on Protein: 53-323
Range on HMM: 6-277/297.0
WLKADSEHRLMEEYDDIQAVGSIVRMDQATNAeVNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|..|..... .  .  .. | .   |..|||.  ||||.|.||||    .....|||||.|..|.. .|..||.|||||.|..| |||.||
lekllflalllkefeellpllllgslsvallp.enleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

KKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELD--YEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE
 ..|.|||.|. || |. ||.|||| ..| | || | . | |.|.    ......||. ...  |. .|.| ....|.|||||||| ....|||.. ||.
qnvtvIvmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

RIRN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHME---DNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
....   .   .||.|||||||||.||.||.| . | .|    .  ||.. .|...|..|.  |||. ||.|....|....
vlkllpsg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 45-323 6e-89 293.7 In-house 17-289 (297) alignment 
Range on Protein: 45-323
Range on HMM: 17-289/297.0
ANIETHYDWLKADSEHRLMEEYDDIQAVGSivRmDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGFNS-PREYIACQGPLPET
  .. .. ..||.| ..|..|. ... .         .. ..||.|||.  ||||.||||||  ..|   ..|||||.|..|..  .|..||.|||||||
svldlllllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

TNDMWRMIWEKKSTIIVMMTKTVEGGKdKCHQYWPKKKGrsdtYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDF
..| |||.|| ..|.|||.||.|| |. ||.|||| . |    . | . | | ..  ......||. ...|.  |.| ..|.|.|||||||. .. .|.|
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllef

VKNVRERIR---NKcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.. |||...   ..   .||.||||||||||||.||.... ...| .  |||  .|.|.|..|.. |||. ||.|..|.|....
lelvrealaelpkg...gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 41-324 3.2e-88 290.8 In-house 4-284 (319) alignment 
Range on Protein: 41-324
Range on HMM: 4-284/319.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNaEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.. ........  |.. .|. | .|. ...  ..   .|.|.. | ||.|||.. ||.|...||.|..|.|. ..|||||..| |..  ...|| |.|| 
eievqeLkerlkalastgetllekefkllkeavnd.tfdsask.eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGrsdTYGGSLEVSLQSELDYEHWITRTFMLQK--NKM-KREVIQLQFTSWPDHGVPEQTK
.|..|.|||.||..| |.||.|| || .| |...|||...    . .| | | |..|   |..| | ..|.|  ...  ||| . |.|.||||.|||...
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenf...eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

PMLDFVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
 .||..|..|.  |.|   .|..||||||||||||.|.||   .... .  .||  .| ..|. || .||.. ||.||.. |...  
slldllkrirks.rektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0045450 (Phosphotyrosine protein) phosphatases II 42-323 9e-88 290.2 In-house 9-304 (307) alignment 
Range on Protein: 42-323
Range on HMM: 9-304/307.0
VLLANIETHYDWLKADSEHRLMEEYDDIQAVGSI-VRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYI--------PGFNSPRE
. . ... ..  |..|. ..| .|. ... |  . .    ... ..||.|||.  ||||.|.||||. |.|. ...|||||.|.        .|....|.
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

YIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQ---KNKMKREVIQLQFTSWP
.||.||||||| .| |||.||...|.|||.|..|| |. ||.|||| . | . |||  . | | ||  ..... ||. ..   .... |.|.....|.||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPEQTKPMLDFVKNVRERIRN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|||||. ....|||.. ||. ...   .   .||.||||||||||||.||.. . ...|..     ||.  .|...|..|   ||.. ||.|....|...
dhgvppsfeelldfieevrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

F
.
l
DSPc_SM00195 64-323 7.4e-87 286.4 In-house 4-262 (263) alignment 
Range on Protein: 64-323
Range on HMM: 4-262/263.0
EEYDDIQAVGSIVrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
||......  |     . .. . ||.|||...||||.|.||||   ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

TVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcvIKPVI
 .| || ||..|||...|.. |.| ...| |...  .. ..|.||. |.|..   .|.| |.|...|||||||..||..|.... |... ...   .|..
eeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
||||||||||||....| . ...|... ||.. .|.|.|..|  .|||..||.||......|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 64-323 7.4e-87 286.4 In-house 4-262 (263) alignment 
Range on Protein: 64-323
Range on HMM: 4-262/263.0
EEYDDIQAVGSIVrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
||......  |     . .. . ||.|||...||||.|.||||   ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

TVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcvIKPVI
 .| || ||..|||...|.. |.| ...| |...  .. ..|.||. |.|..   .|.| |.|...|||||||..||..|.... |... ...   .|..
eeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
||||||||||||....| . ...|... ||.. .|.|.|..|  .|||..||.||......|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 46-323 1.2e-86 285.9 In-house 6-277 (278) alignment 
Range on Protein: 46-323
Range on HMM: 6-277/278.0
NIETHYDWLKADSEHRLMEEYDDIQAVGSivRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTND
... .. .|.... ..|..|. ... .     .   .. . ||.|||.  ||||.||||||  |.|   .|||||.|..|.| ||..||.|||||||..|
dllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPkkkGRSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||.|| ..|.|||.|. || |. ||.||||   | | || | . | |..|  ......||. .   ... .|.| ......||||||||.....|||.
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggslty.gdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

KNVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
| |||.....   .||.||||||||||||.|||..| ...|.. .||.. .|.|.|..|   |||. ||.|....|..|.
kavrealedsn..gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 49-326 2.2e-84 278.2 In-house 16-293 (298) alignment 
Range on Protein: 49-326
Range on HMM: 16-293/298.0
THYDWLKADSEHRLMEEYDDIQAVGSIVRMD--QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
   .  |. .  .. .|.  ...| | .. .  ...... || |||. .|.....||| | . ... |.||||| .. ...    .||.|.||.||..| 
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||..|.... |||.|...| .| |.|.|||...  ..||| ...|||.|. ..   |.|.....|.|   .||| ||.||||||.||||... .||...
WrmvteedigtiVmltnleeldktkyhkywPdeg..ketyg.eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

NVRErIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
.||   ....  |||||.|||||||.||.||.| . .... .  |||  ||  .|..|  .||||.||.||..  .... |.
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
subfamily_PTPRA_pd Subfamily PTPRA 35-326 6.3e-84 276.7 In-house 7-298 (330) alignment 
Range on Protein: 35-326
Range on HMM: 7-298/330.0
KNRVSRPVLLANIETHYDWLKADSEHRLMEEYDDIQAvGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIA
 |.   |. . ..|   .  .||  ... ||.. . | |.|    .... | || |||. .||||..||| |  ..|. |.||||| .| |..   ..||
gnkkyfplpvekleeeirirsaddnklfreefnalPa.gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfia

CQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYGgSLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWP
.|||. || .|.||||||.||. |||.|.  |  ..||.||||.. | . |||  . |... |   ...  | |..|      ..| .| | |. |||||
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyG.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP

DHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
| ||| ... ||...|.|..   |.    |..||||||||||||.|.|| . . .. .  ||| ..| ..|. |  .|||. || ||.  |..|.  |
dvGvPfepiGmlkllkkvkkl..nqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
Y_phosphatase Protein-tyrosine phosphatase 87-320 4.1e-83 273.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 87-320
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
||.|||...||||...||||   ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....| |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGsLEVSLQ-SEL-DYEHWITRTFMLQKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLT
||  ..| |. .|  | .....|.. |.|.| .   ||| ||..|.||||||||..|..||....|...   .   .||.||||||||||||..||| | 
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 87-320 4.1e-83 273.8 In-house 1-234 (235) alignment 
Range on Protein: 87-320
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
||.|||...||||...||||   ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....| |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGsLEVSLQ-SEL-DYEHWITRTFMLQKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLT
||  ..| |. .|  | .....|.. |.|.| .   ||| ||..|.||||||||..|..||....|...   .   .||.||||||||||||..||| | 
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 41-326 6.4e-83 273.4 In-house 3-286 (305) alignment 
Range on Protein: 41-326
Range on HMM: 3-286/305.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDqatNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.. |......    ...|.. | ..|. ..  .. . ..   . |.||.|||...| .....|..| . . . ..|||||.|. |...  .||. ||||.
iialddlaayikearvysdkgleaqykslyeeeesidvg...kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTK
.| .| ||.|.| | . |||.||.||||||||.||||..|...  . |...| |.||  .. .|.| . . .   .| .| |.|.|.|.|||||||... 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PMLDFVKNVRERIrNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
 .|...|.|...  .|   .|..|||||||||||..||.|   ....  . ||| .|. ..| .| ..|||  || |.|| | ..  .|
sllslikrvqkdq.kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_PTPN12_pd Subfamily PTPN12 57-325 1.2e-81 268.8 In-house 5-279 (290) alignment 
Range on Protein: 57-325
Range on HMM: 5-279/290.0
DSEHRLMEEYDDIQAVGSIVRMDQ-----ATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIW
..|... .|. ..... .  ....     |...|.|..|||.  ||||..|||.|   ... . ||||||.| | ... |||| |||||.| .| |||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

EKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI
||. .|.||. . || || ||..|||...... ..| ..||.|..|   .  .. ||. ....| .|.| |...|.|||||||...|..|.....|||. 
eknveivvmaCrevelgkkkCerYWpeegeeelefg.efevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelq

RNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
...   .|..|||||||||||| ||.|   . ....     .||  .| |.| .|. ||||. || ... ........
ese..daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
0040439 (Phosphotyrosine protein) phosphatases II 83-323 3.2e-80 264.6 In-house 7-246 (249) alignment 
Range on Protein: 83-323
Range on HMM: 7-246/249.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. ..|| |||.  ||||.||||||  |.|   .|||||.||.|....|..||.|||||||..| |||.|| ..|.|||.|..|| |. ||.||||   | 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

SDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN---KcviKPVIVHCSAGVGRTGTYIALD
| .| | . | | |.  ......||..|.  ... .|.| ..|.|.|||||||. ....|||.. ||. ...   .   .||.||||||||||||.||..
sley.gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkg...gpvlVHCsaGvgRtGtfiaay

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
 . ...| .  ||.  .|...|..|.. ||.. ||.|....|....
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 83-323 5.5e-80 264.0 In-house 29-272 (278) alignment 
Range on Protein: 83-323
Range on HMM: 29-272/278.0
NAEVNKTKNRFNKILPYEHSRVKlmalkgksetDYINANYIPGFnsPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. . |. |||.  ||||.|||||          |||||.||.|.  |...||.|||||.|..| |||.|| ..|.|||.|. ||.|. ||.||||   | 
lylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..gg

SDTYgGSLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWPDHGVPEQT--KPMLDFVKNVRERIR--------------NKcviKPVI
| || | ..| |.||  ......||....      .. ..|.| .|....|||||||...  |..|.... .||...              ..   .||.
slty.gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg...gpvl

VHCSAGVGRTGTYIALDRLTQHMedNDFVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLMDYF
||||||||||||..|.. . ...  .. ||.  .|.|.|..|..  ||.. ||.|....|....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0042113 (Phosphotyrosine protein) phosphatases II 83-323 2.6e-79 261.4 In-house 5-243 (245) alignment 
Range on Protein: 83-323
Range on HMM: 5-243/245.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. ..||.|||.  ||||.|.||||.  .|   .|||||.|..|.. .. .||.|||||||..| |||.|| ..|.|||.|...| |. ||.||||   | 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

SDTYGGsLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIR--NKcviKPVIVHCSAGVGRTGTYIALDR
| |||. . | | ||  ......||....  ... .||||......|||||||. .. .|||.. ||. ..  ..   .||.||||||||||||.||...
sltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsn...gpvlVHCsaGvgRtGtfiaayl

LTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. ...| .  |..  .| |.|..|   |||. ||.|....|....
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 60-322 2.9e-79 261.2 In-house 26-296 (306) alignment 
Range on Protein: 60-322
Range on HMM: 26-296/306.0
HRLMEEYDDIQAVGSIVRMDQA-TNAEVNKTKNRFNKILPYEHSRVKLMaLKGKSETDYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKST
  ..||....|   .  ....  ..   ||.|||.. |||..|.||.|   .. ...||||||||     .| ..||| || |..| .| |||.|...|.
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

IIVMMTKTVEGGKDKCHQYWPKKKGRSDtYgGSLEVSLQSELDYEHWITRTFMLQ---KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNK
.|||.|| || ||.|| .|||... ... | |...|.  || . ...| |.....   |.| .|||.|..|.||||||||.... .|||...|... .. 
vivmttkevErgkekCarYWPdeeekee.y.GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

C--VIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
      |..||||||.|||||.| .| |.. .| . .   .|.  .|  .| .|. |||||.|| |..  .  |
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_Ptp69D_pd Subfamily Ptp69D 42-324 3e-79 261.3 In-house 4-287 (307) alignment 
Range on Protein: 42-324
Range on HMM: 4-287/307.0
VLLANIETHYDWLKADSEHRLMEEYDDIQAVgSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPE
. . ..|. .   | |... |..||. ..|   | .  .... . |. |||...| .... ||||  ..|| ..|||||..| |..  ...|| |.|. .
iaiddleealksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK-------MKREVIQLQFTSWPDHGVPE
| .| ||||.|...|.|||...  |  ..||..|||.       || .. | | ||   ...| |.. . |.|        .|.|.| ..|.|.|  |||
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

QTKPMLDFVKNVRERIRNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
... .|.....|||  ...    |..|||||||||.|...||| | |... .| ||.. .|...| .|| |||   ||.|..  |.||  
vargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN9_pd Subfamily PTPN9 47-323 4.3e-79 260.6 In-house 3-290 (297) alignment 
Range on Protein: 47-323
Range on HMM: 3-290/297.0
IETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDqATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
||   ...|.  .. |..|| .|..     ... |..  .| .|||.. .| |...||.|  .......||||||.. |.. .. .|| ||||..|..| 
ieelvayvkekgkrGlskeyaeirnepveGtfl.asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||.||..  .|||.|..|| |. || ||||.... |. .| .|.||  .   .|.. .|.. ..  |.. .|.|.  ||.||||.|||.... .||...
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg.dlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

NVRER-----------IRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.|||.            . ..   |..||||||.|||||.|.||   ...|. . |||. .|  .|  | . .||. || | . ....| 
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN3_pd Subfamily PTPN3 64-322 1.3e-77 255.5 In-house 19-274 (280) alignment 
Range on Protein: 64-322
Range on HMM: 19-274/280.0
EEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYI----PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
 ... .      . ...|  .| | .|||.  ||||.. ||||     .||||||||||.    |. .    |||.||||..|..|.|.|.||.||..||
aqfeqlyrkkpglaisaarkpe.nlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MMTKTVEGGKDKCHQYWPKKKGrSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRnKCVIK
|.| .|| |. |||||||...  . .|| ...| ...|   . ...| ..|....   .|...|||...|||||||.... .|.||..||.  | .   .
mlttlverGrvkChqyWPeted.eleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.r.sgkee

PVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
||.||||||.|||| .|.|.   . .| .. | .  .| .||  |  ||||..|| |. ....  
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 40-326 2.7e-77 254.8 In-house 4-282 (315) alignment 
Range on Protein: 40-326
Range on HMM: 4-282/315.0
RPVLLANIETHYDWLKADSEHRLMEEYDDIQAvGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPL
.|. | .. |.    || ..  . ..|. |   | .  .| | . | || |||. .|..|..|||.|  |. ....||.|||.|.|.| .| |||.|||.
qpipldqlityvaqkkastkngfkqdyesipg.gqlhpldvakkie.nkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

PETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgrSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPM
... .|.||...|.. . |||.|..||| | |. .||| |     .| | . |...||  ....  ||.    ..  |||.||..||||| |||. | |.
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviy.Gkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytipl

LDFVKNVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
......|.    |.    ...||||||||||||.|.|| . ...| .. .||  ..  .|  |  .||.  || ||.| |.. |  |
mnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 62-323 4.6e-76 251.0 In-house 20-276 (515) alignment 
Range on Protein: 62-323
Range on HMM: 20-276/515.0
LMEEYDDIQavGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
. ||. |.   |  .  .  .. |.| .|||.. ||||. .||||  .. . . ||.|| |||.|.. . ||| |||.. ...|.||...... | |.|.
fseefhdlp..gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRNKCViKPVIV
||  || | || .|||.| | |  .| |..|.| |       | |.. . |..  | | | .|| |||.|||..|. .| ..|.|.   ...    |.|.
tklkegdkikcgkyWPdkpgdsvkfG.sikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkad.hgqyt.hplii

HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|||||||||| .|..|    |... . |||  .|  .| .| |||||. || ||.. .....
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 82-323 7.1e-76 249.9 In-house 23-268 (274) alignment 
Range on Protein: 82-323
Range on HMM: 23-268/274.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSE-TDYINANYIPGFNS-PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
..   ..||||...||| |.||| | . ....| ..||||||| |..   . |.| |||||.| .|.||||.......|||.||  |  ..||..|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

KGR--SDTYGGsLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRER-IRNKCVIKPVIVHCSAGVGRTGTYIAL
..   |..||. .|.  .. .. ...  |...|.. . .|.|.   .|.|||| .|......||.|..|.|   ...  . ||.||||||.|||| .|| 
edyeiserygd.veikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.   ...... .||| ..||..|..|  .|||. || .||  |. | 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 57-322 1.5e-75 249.4 In-house 31-290 (319) alignment 
Range on Protein: 57-322
Range on HMM: 31-290/319.0
DSEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKST
|   .|  |.  .  .|      . .| . || |||. .||......|||  | |.  .||||| .. |. ..  |||.||||..| .|.|||||| ...
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

IIVMMTktveggKDKCHQYWPKKKgrsDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNK
 ||..|      |||| ||||.|    .   .  .|...|  . . .. | . | .   .| .|.. |  |  |||.|||... ... .||.||   . .
tivllt......kdkcsqywplki...vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

CVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
   ....|||||||||||.||.|| | . |.... |||  .| ..|  || |||  .|| ||.  |.. 
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPN13_pd Subfamily PTPN13 63-320 2.3e-75 248.4 In-house 14-266 (273) alignment 
Range on Protein: 63-320
Range on HMM: 14-266/273.0
MEEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMALKGksetdYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVM
 ||..... . .. . ... ..| ||.|||. ..|||...|||| .  |     ||||..|     .   ||||||||||||..|.|.|.||.|...|.|
aeefkelrelkpldtcevgkkke.nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

MTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKM--KREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRnkcVIKP
.|. .|.|| |||.|||..|... .  . |||.|    ... .  |........    ||| .|.|..||||||| .....| ||..||.  .      |
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagP

VIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..||||||.||.||.|..| . . .| .  .||  .| ..|  |. .|||. ||||..  ..
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 84-323 4.1e-75 247.2 In-house 6-242 (250) alignment 
Range on Protein: 84-323
Range on HMM: 6-242/250.0
AEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDkCHQYWPKKKgrS
   || |||. .|.....||| |   ||  |.||||| .. |..  . .|| ||||..|..|.|||..|.||. |||.|. .| .|  .||||| .|  .
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..a

DTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKRE--VIQLQFTSWPDHGVPEQTKPMLDFVKNVReRIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ
..|| .. ||| |.  .  ...|...| |.| . |  | ||.|..||| ||||... .|...|.|. . ....  .||||.|||||||.|..||.| . .
ekyG.dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq.asqqqagnaPvivqCsaGvgrsGafiaidavle

HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
... .  |||  |.  .| .|   |....||.|..  .. . 
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
0037934 (Phosphotyrosine protein) phosphatases II 83-323 2.6e-74 245.1 In-house 6-242 (243) alignment 
Range on Protein: 83-323
Range on HMM: 6-242/243.0
NAEVNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIPGFnsPReYIACQGPLPETTND----MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPk
. ..|..|||.  ||||.||||||      . .||||||.|...  || .||.|||||||..|     |||.|| ..|.|||.|..|| |. ||.|||| 
llpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

kkgrSDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN---------KcviKPVIVHCSAG
    .... | ..| | ||  ..... ||..|.    .. .|.||......|||||||. ....|||.. ||| |..         .   .||.||||||
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg...gpvlVHCsaG

VGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLMDYF
||||||.||.. . ...   . ||.  .|...|..|..  |||. ||.|....|. ..
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 80-322 5.8e-74 244.1 In-house 18-254 (284) alignment 
Range on Protein: 80-322
Range on HMM: 18-254/284.0
QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTktveggKDKCHQYWPKK
. .| . || |||. .||......|||  | |.  .||||| .| |. ..  |||.||||..| .|.|||||| ... ||..|      |||| ||||.|
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

KgrsDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIAL
    .   .  .|...|  . | .. | . | .   .| .|.. |  |  |||.|||... ... .||.||   . .   ....|||||||||||.||.|
i...vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
| | . |.... |||  .| ..|  || |||  .|| ||.  |.. 
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPRK_pd Subfamily PTPRK 50-324 2.8e-73 241.5 In-house 12-279 (314) alignment 
Range on Protein: 50-324
Range on HMM: 12-279/314.0
HYDWLKADSEHRLMEEYDDIQAVgsivrMDQaTNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRM
.   ||.   . . |||. .         |  .. . |..|||...||.|..|||.|....| ...|||||..| ... |...|. ||||.||..|.||.
siallkraegygfkeeyeslfeg.....wda.akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

IWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgrSDTYGgSLEVSLQSELDYEHWITRTFMLQK----NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKN
....... |||.|. || |. || .|||..   ...||  ..| | .    .  ..|.| ..|     . .||| |.||..||||.|| . . .|..|..
vydencasivmltelvevgrvkClkyWPed...tevyg.dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr

VRERIRNkcVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD-YFC
| .   .     ...|||||| |||||.||.| . . .| .. |||  .| ..| ..  .|.|| ||.||.| ...  .|
vkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 78-323 8.7e-73 239.9 In-house 35-277 (315) alignment 
Range on Protein: 78-323
Range on HMM: 35-277/315.0
MDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWP
  ...  ..| .|||.. |||....||||  .  . . ||||| ||..... . ||| ||||. . .|.|||....| | |||.||  || | || ||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

KKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALD
..|. |  .| |..|.| |       ..| ....| . .| | | ||| |||.||..||  .| ..|.|.    |.    ...|||||||||||  |..|
drkadsvefG.sikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisid

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
   ....... |||  .| ..| .| |||||| .| ||.| .....
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 83-322 3.5e-70 231.1 In-house 16-263 (270) alignment 
Range on Protein: 83-322
Range on HMM: 16-263/270.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKG
.|  .|. ||.. |||  ..||.|  |. .|.| ||||||..||. ....||| .|||| |... ||||||.|.| |||.|. .| |..|| .|||....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

R-SDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTK------PMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYI
.  ..  | ..|  .||   | .|..   |...  .|...  ....|||||||...        .|  ...||.  ...   .|..|||||||||||| |
ekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

ALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|||  .. .| .  |||  .. |.| .|  |||.  || |..  .. |
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 44-327 1.2e-69 230.0 In-house 7-292 (325) alignment 
Range on Protein: 44-327
Range on HMM: 7-292/325.0
LANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETT
. |.  | .  ||. .  .  |.. . ....| .  ...    || ||||. ......||| | ..| ....|||||.|.  .     ..|.| ||..|.
vvnlvehvekkkaqdqdgfahefgllpsddgiak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

NDMWRMIWEKKSTiIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGsLEVSLQSELDYEHWITRTFMLQKNKMK--REVIQLQFTSWPDHGVPEQT---KP
||.||.. . ... .|...  ...|||.| .||||. | | |.|| |||.|..  ..  .. | . ... |    | | |.|. ||.| ||...     .
ndlWrlvldWrcs.vvvvlneldlgkdrcavywpkemgksktfGg.levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis

MLDFVKNVRERIRN-KCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSGV
.|. ||.| ||..       |..|||||||||||..|.|  . ... ..  ||. |.|  .| .|  .|.|  |||.|...|.... || 
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
subfamily_PTPN14_pd Subfamily PTPN14 59-323 7.2e-67 220.5 In-house 22-296 (300) alignment 
Range on Protein: 59-323
Range on HMM: 22-296/300.0
EHRLMEEYDDIQAVGSIVRMdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKsETDYINANYIPGF--NSPREYIACQGPLPETTNDMWRMIWEKKST
| ..  ||. |.       . .... ..|. ||||...||||..||.|.. | . .|.||||  |      . |.||..||||. | .|.|.|.||.. .
egkvfteyeripkkredall.staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

IIVMMTKTVEGGKDKCHQYWPKKKGR--SDTYgGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNV---RER
.|||.|.. |.||.|...|.||.. .  . .. |  .|. .   | .  ||... |.    | .|.|. ||.| ||||||||  |..|.....|   |..
livmlteeeedgkeksfkyfPkleskkktvef.gkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

IRNKC----VIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
  ..     .  ||.|||||||||||  |  | |.. .| |. .|.  |.  .|  | .|||| .|| |... |. |.
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 71-325 7.3e-67 220.6 In-house 35-286 (297) alignment 
Range on Protein: 71-325
Range on HMM: 35-286/297.0
AVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKd
   . .. .  ..  ||  |.|.. ||||. |||||  .  . . ||.|| ...|..   ..|. | | ..| .|.|.|..... ..|||...  |. | 
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.

KCHQYWPKKKGRSdtyGGSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPE--QTKPMLDFVKNVRERIRNKCVIkPVIVHCSAG
|| .||..|   .    |.. | |.|  . |  | |.. ..|.|  ..| | | ||..|||. |..  ... .|.....||.   ..    |..|||.||
kcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaG

VGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
||||| ....|    ...... ||. |.|  .| .| |||||. || |..  ..... |
vGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 79-324 6.1e-66 217.2 In-house 38-284 (290) alignment 
Range on Protein: 79-324
Range on HMM: 38-284/290.0
DQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSE--TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYW
 .  ... ||..|||..|..|.  |. |  . |. .   .|||| || |..  ..||| |||...|  | |..||..|.|||||.|. .| ||.||.|||
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PKKkgRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKM---KREVIQLQFTSWPDHG-VPEQtKPMLDFVKNvRERIRNKCVIKPVIVHCSAGVGRTGT
|..   ...| |  .. |..|  ... |.|.. .....    |..|.|.|.|.|...| |... . .|  ... ..... |   ....||||..|||...
pds..dtkay.gefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp.qtillviee.myktqrkrgntsivvHCSdtvgrsav

YIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
..|..   .... .  .||  |. ..|. .  .|||. || .|.. .. |. 
fcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 87-320 9.5e-66 216.4 In-house 3-236 (237) alignment 
Range on Protein: 87-320
Range on HMM: 3-236/237.0
NKTKNRFNKILPYEHSRVKLMALKgkSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgRSDT
|| |||. .|  |.|||| |      |..|||||.|. ||. .|..|||.||||  . .|.|.|.|..| ..|||.|  .|| . |||.|||. . .  .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa

YGgSLEVSLQSELDYEHWITRTFMLQKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQH
||  | |||. . ..  .  |...|.|.  ..||    | |||||||.|||.||  .| | ||. .| .      | |.|||||||||| .. .| . ..
yg.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
 ...  ||.   |  .   | |..||. ||.|||. ..
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPN23_pd Subfamily PTPN23 57-320 1.5e-65 215.9 In-house 18-277 (288) alignment 
Range on Protein: 57-320
Range on HMM: 18-277/288.0
DSEHRLMEEYDDIQavgsiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKS
| .....|...| .      |    . |... .|||.. ||||.|.||||     .|. ||||| .. .  .   ..|| |.||..| || |.|..|.||
dkkfkeleqkqdke.....arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

TIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGsLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE---RI
 .|||...  | || |...|||..||.. ..|  |.|.|.|. . |... |.. |. ..   ...|  ||.||||..|||.  . .|.|...|..     
sviVmllskeelgkpkvdrYwPedkgetvkfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

RNKCVIkPVIVHCSAGVGRTGTYIALDRLTQH-MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..|. . |..|||||||||||..  .    .   ..|  .|.  ||  .|  | . ||...|. |  .  .
qrkskt.PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 83-325 5.6e-62 204.3 In-house 43-280 (287) alignment 
Range on Protein: 83-325
Range on HMM: 43-280/287.0
NAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGr
 |. || |||...||...  || |     . . ||||| .| |... ...|....|. .|  ..|..|.... |.|||...  |  ...|.||||..|  
iasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

sdTYGGSLEVSLQSELDYEHWITRTFMLQKN---KMKREVIQLQFTSWPDHG-VPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDR
  .. |  ...| .|  ....| |.. ....   . |..| | |.|.|...| |.|.   .| . . ....   |    ...||||..|||.....| . 
..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq..rkrgntsivvhCsdtvGrsamfcaaat

LTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
  .. . .  .||  |. ..|. .   ||| .||.|| | .. |  |
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN1_pd Subfamily PTPN1 64-316 9.9e-61 200.0 In-house 10-264 (290) alignment 
Range on Protein: 64-316
Range on HMM: 10-264/290.0
EEYDDIQAVGSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
| | ||.   | ... .| . . |...||.  . ||.|||.||     ....|||||. .   .  |.||  |||||.|.. .|.|.||.||  .||. |
eiyldirkeasdfptrea.klpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

TVEGGKDKCHQYWPKKKGRSDTYG--GSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPV
 || .. ||.||||...  .       .|.| | || ...... |.. |..   .  ||...  .|.||| ||||    .|.|. .|||    .    |.
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

IVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIH
..|||||.||.||.. .| .  ..|..|    ||.  |..|.| .|  |.||  |  | .
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 74-323 1.4e-60 199.5 In-house 26-277 (287) alignment 
Range on Protein: 74-323
Range on HMM: 26-277/287.0
SIVRMDQATNaEVNKTKNRFNKILPYEHSRVkLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCH
| . . .|..   .  |||. ..||....|| |.. .|.  .|||||||.....   ..||.|||.. | .|.||...|..|. ...||. || .. ||.
statfkaaee.laavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPKKkGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKR--EVIQLQFTSWPDHGVPEQTKPMLDFVKNV---RERIRNKCVIKPVIVHCSAGVG
.|||..  .    ||   | |. .    .. .|.. | . . .    | ||.. ||||....  .  .. || .|    |  |.   . |..||...|.|
kywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|.|...|.  | . .||   |||  ||  .|..|. |||.  |. .. . |. |.
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 48-322 4.4e-58 191.8 In-house 8-278 (439) alignment 
Range on Protein: 48-322
Range on HMM: 8-278/439.0
ETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQATNA-EVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
. | . |. . .  . |... |...    . . .  | | ..||||.... ...|.|| |  . |   . ||||||| |.  .. |||.|||  |||.|.
qehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WRMIWEKKSTIIVMMTKTVEGGKdkchqYWPKKkgrSDTYGGSLEVSLQSELDYEHWITRTFMLQ----KNKMKREVIQLQFTSWPDHGVPEQTKPMLDF
||...|||.. |||.|. ||  |     ||| .   .... | . |  . ...  ... | | .     ... .| |.|.....|||. || |.  .|||
wrlviekktvtivmltnlvesyk.....ywpsd...aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

VKNVRErIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
.. .     .|  . ||.|||||||||||| ||||   ...  .. ||. |.|  .| .|. .||.  ||.||...... 
lrains.andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_CG7180_pd Subfamily CG7180 85-325 1.3e-57 189.7 In-house 40-292 (296) alignment 
Range on Protein: 85-325
Range on HMM: 40-292/296.0
EVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKdKCHQYWPKKKgrSD
. |. |||  |..||.. || |  |.|....||||| |. .|  ..|||  ..|  || .. ||.......  .|..||| .  | ....|||.|     
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..ke

TYGgSLEVSLQSELDYEHWITRTFMLQKN------K------MKREVIQLQFTSWPD-HGVPEQTKPMLDFVKNVRER---IRNKCVIKPVIVHCSAGVG
 ||  ..| . .|  | .  .||| |.|.      .       .| | ..|.| |.  . ||  |. ...... ||     . .. . .||.|..| |..
qyg.eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
|.| |.|.|   . .| .. ||| . |  .| .|. ||.. ..| .| | | ...  
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_PTPRN_pd Subfamily PTPRN 58-320 2.2e-57 189.0 In-house 27-289 (297) alignment 
Range on Protein: 58-320
Range on HMM: 27-289/297.0
SEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPRE--YIACQGPLPETTNDMWRMIWEKKS
 ..|| .|.. . |  .  .  ....|| | .||| ...|||.|||||| .   ....|||||  |   . ||.  |||.||||..|  |.|.|.||. .
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGv

TIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYGgSLEVSLQSEL-DYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN
..||..|.  | |  .|..|||.. | |..|.   || | ||    . .. |.| |.  ...  | | |. | |||..||| ..|..|.| . |    | 
vvivnltrleeegvkqckrywpde.G.sevyh.iyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG

KCVikPVIVHCSAGVGRTGTYIALDRLTQHMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..   |..||||.|.||||.||..| . ...      .|..  .  .|  |. ||.|. |. |.  .. 
rsc..pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 62-320 7.8e-57 187.4 In-house 22-233 (392) alignment 
Range on Protein: 62-320
Range on HMM: 22-233/392.0
LMEEYDDIQavGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
..||. |.   |  .  ..... |.|. |||...||||. .||||  .   ...||.|| |||.|.. . |||.||| . . .|.|||..... | |.|.
ffeefhdlp..gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TKTVEGGkdkchqywpkkkgrsdtyggslevslqseldyehwitrtfmlqKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIV
||  ||                                            | . .| | | .|| |||..||..|  .| |.|.|.         .|.|.
tklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf..Gqythplii

HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
||||||||||  |..| .  | .   .|||  .| ..| .| |.|||. || ||. ...
hcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 81-319 1e-56 186.8 In-house 2-237 (239) alignment 
Range on Protein: 81-319
Range on HMM: 2-237/239.0
ATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
|..  |||.|||. .|. |.|||| |  |     .|||||.|.  .. ||. ||| || .  .. |.|||.|...  .|||.|  .|| | |||||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

KGRsdtYgGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALD
  .   |   | |.|.    .  .| |||.. .     .| | | .|| |||.|||. .  .| . ... .   .    .| ..||||||||||... .|
tsk...y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvid

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
 . .. . .  ||.   |  .|  | ..|||  ||.||| ..
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 83-319 1.4e-56 186.3 In-house 3-236 (239) alignment 
Range on Protein: 83-319
Range on HMM: 3-236/239.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKG
.  |||.|||. .|. |.|||| |  |     .|||||.|.  .. ||. ||| || .  .. |.|||.|...  .|||.|  .|| | |||||||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

RsdtYgGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDRL
.   |   | |.|.    .  .| |||.. .     .| | | .|| |||.|||. .  .| . ... .   .    .| ..||||||||||... .| .
k...y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidam

TQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
 .. . .  ||.   |  .|  | ..|||  ||.||| ..
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 75-321 1.2e-53 176.8 In-house 21-264 (283) alignment 
Range on Protein: 75-321
Range on HMM: 21-264/283.0
IVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGksetDYINANYIP---GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDK
  .  . . |. ||.|||...|.|..  ||.| ..      ||||| .||     .  ..||..|.|| .|  |.|.|....| | |||.||  |. . |
pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

CHQYWPKKkGrSDTYgGSLEVSLQSELDYEHWITRTFMLQKN---KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREriRNKCVIKPVIVHCSAGVG
| |||||. | |  | | . |.|. |   . .| . ..|..|   | .  .   |.  | . |       .. | | .    ...    |..||||.|.|
CsqyWPkr.G.sedy.GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvisl..qteskkgPivvhCstgiG

RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
||...||.    ...  .  |||  ||  || .|  .|||  || ..|.  ..
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
0051429 (Phosphotyrosine protein) phosphatases II 115-325 4.1e-53 176.1 In-house 4-227 (272) alignment 
Range on Protein: 115-325
Range on HMM: 4-227/272.0
TDYINANYIPGFNS---PREYIACQGPLPETTNDMWRMiWEKKSTIIVMMTKTVEGGKDKCHQYWP---------KKKGRSDTYGGSLEVSLQSELDYEH
..||||....|...   |. .....|||| | .| ||. .| . . ||......| |..||..|||            .  .   | | | |.||  ...
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

WITRTFMLQ---KNKMKREVIQLQFTSWPDHGVPEQTkpMLDFVKNVRErirnkcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVD--------V
.| |...|    .... ||| .|..|.|||||||...  .|.... ...        .||.||||||..||||..||..| . ..... ||        .
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

CGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
 ..| |.| .| . ||||.||.|....|.....|
eeaveelraqrpgavqteeqylflyeallellrs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 61-323 1.7e-52 173.0 In-house 16-293 (301) alignment 
Range on Protein: 61-323
Range on HMM: 16-293/301.0
RLMEEYDDIQAVGSivRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKG--KSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTII
.. |.|.... . .  .  . .  | ||. |||..| .|.. |. |   .   .....||||.|| |... ...|| |||. .|  |.||.||..| . |
kfeeqykelkeged..ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELDYE-----------------HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLD
||.|.. || |.||.||||. . .|... | ..| |..|  |                    | |.|  ...|  ..|.||| |.||..||  . . .| 
vmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

FVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
 . .|  | ..|    ||.||||..|.|.|.|....        .  ||| .|.  .|  .   |.|  ||..|.| .  |.
viddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
0041856 (Phosphotyrosine protein) phosphatases II 87-324 5.3e-52 171.4 In-house 1-172 (182) alignment 
Range on Protein: 87-324
Range on HMM: 1-172/182.0
NKTKNRFNKILPYEHSRvklmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTktveggkdkCHQYWPkkkgrsdty
|..|||. .||||.|||            ||||||.. |   ....||.||||..|..|..||..| . |.||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ggslevslqseldyehwitrtfmlqkNKMKREVIQLQFTSWPDHGVPEqTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIALDRLTQHmedn
                          .. .|..||.....|||||||. .  .|||.. |.|        .||.||||||||||||..|.. . ..    
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

dFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
  |..  .|...|..|.  |.|. ||.|....|.... 
.gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 82-324 2.3e-49 163.0 In-house 35-278 (307) alignment 
Range on Protein: 82-324
Range on HMM: 35-278/307.0
TN-AEVNKTKNRFNKILPYEHSRVkLMALKGKSeTDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKK
..  . |  |||.. .   ...|. .. ..| . .||| |||.     |. .|..|||| .|  ..| |. ..|   ..|. |..| .| ||.|||| ..
veafsantdknryqdvkcqdkgri.vvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

GRSDTYGGSLEVSLQSEL------DYEHWIT-RTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnkcviKPVIVHCSAGVGRTGTY
|.  ..| . .    ..|        |. |   |. ..  .  | . .||.. |||.|||.     ..... ||          ||.|||||||||.|| 
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt......npvvvhcsaGvGrsGti

IALDRLTQHM-EDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
.|.  . . | .  .  |.  .| |.| .|.| .||| ||...|  |..|| 
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0036282 (Phosphotyrosine protein) phosphatases II 115-317 9.5e-49 160.7 In-house 2-164 (174) alignment 
Range on Protein: 115-317
Range on HMM: 2-164/174.0
TDYINANYIPGFNSPREYIACQGPLPettndMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkgrsdtyggslevslqseldyehwitrtfmlQKNK
.|||||... ..  ....||.||||.      |.|..| ..|..||... .| |. ||..|||                                  .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

MKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVRERIRNkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEdNDFVDVCGVVCEMRMHRNYLVQTETQYIF
..|..||.... |||||||. .. .|.||| |.| . . .  .||.|||||||||||| .|.... .... ...||.. .| |.|..| . |||. ||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IHD
...
lyy
subfamily_ptpA1_pd Subfamily ptpA1 60-275 2.9e-46 153.0 In-house 27-248 (418) alignment 
Range on Protein: 60-275
Range on HMM: 27-248/418.0
HRLMEEyddiqAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
 ||.||     .||         . . | .|||. .||| .|.||.|  .. |  .|||||||| |   |...|. |||||.|  |.|||.||..  |||
frllee.....svgpset..segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriiv

MMTKTVEGGKDKCHQYWPKKKGRS--DTYGGSLEVS------LQSE-LDYE-HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRER
|...  |  . || .|||.. |      ||   ||       |     | |   |||   |  .   |.. | |.  |||| .|..|.|. ...... .|
mlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

I----RNKCVIKPVIVHCSAGVGRTGTYIA
      .     |.|||||||||||||. .
qnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 84-322 5.7e-46 151.5 In-house 53-282 (290) alignment 
Range on Protein: 84-322
Range on HMM: 53-282/290.0
AEVNKTKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPreYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRS
.. . .|||.  .   . .||    ||   . ||. |||. | ...  .|  ||.| .|. |.|||. ..| . |||. . .| || ||.||.|.|.|. 
kntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

DTYGGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIALDRLTQ
 |.|    .  ... . .. | .|. ...     .  .  |.  ||||. |.  |  .|  .. .|.      .  ||.||||||.|||||..|..   |
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglq

HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
 . |   .|. ..|  .|  |   || ..||. . . |.|.
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 57-324 6e-46 151.5 In-house 27-290 (305) alignment 
Range on Protein: 57-324
Range on HMM: 27-290/305.0
DSEHRLMEEYDDIQAVGSIVRMDQAtnAEVNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKS
  | | .  |   .    ..  .|.  |....||||.. .   ..| |||   .  | .||| |||.     | . .|..|||| .| ...| |. ..| 
reefrglakytrpdmtqvafnanqs..adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

TIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLE---VSLQS--ELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREri
  |||. |||| || || ||||  .|   .  . .    ||     | | |  ||   .    . |  | .||.| ||| |||      |...  .|   
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg..

rnKCVikPVIVHCSAGVGRTGTYIALDRLTQHMEDND-FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
    |  |..||||||.||||| .|.. . ... .|     .  .|  .| .| . .|.. ||.|||  ...|| 
..skv..pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
0043147 (Phosphotyrosine protein) phosphatases II 113-316 5.9e-45 148.4 In-house 3-154 (172) alignment 
Range on Protein: 113-316
Range on HMM: 3-154/172.0
SETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTveggkdkchqywpkkkgrsdtyggslevslqseldyehwitrtfMLQK
. .|||||.|...   |...||.||||..|..| |||..|.. |.||..|.                                             .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

NKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVRE--RIRNKcviKPVIVHCSAGVGRTGTYIALDRLTQHMedndfvDVCGVVCEMRMHRNYLVQTET
 . .|..||.....|||||||  .. .|.|.. ..|   ....   .||.|||||||||||| .|.. . ...      ..  .|...|..|.. ||.. 
ellerlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnps

QYIFIH
||.|..
qyrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 57-322 2e-43 143.3 In-house 3-258 (267) alignment 
Range on Protein: 57-322
Range on HMM: 3-258/267.0
DSEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKST
|.|  . .|.. |. . ..        || |. .||... |||...|| |     ..| .|||| |. |..  . .|. |.||  |  | . .| ..| .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

IIVMMTKTvegGKDKCHQYWPKKKGRSDTYGG-SLEVSLQSELDYEHWITRTFMlQKNKMKREVIQLQFTSWpdhGVPEQTKPMLDFVKNVRERIRNKCV
.||..||.   ..|. ...|| | |..  |   ..| ||. | .  . ||  .   ||.  ..|    .  |    .  . || |  .  .  . . .  
vivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw...nintnnkpylkplfgilaknqleng

IKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
 .|..|.||.||||.||.. .|   . .  .. .|.   . ..|  |  ||.|  .||.||. | .|
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0046846 (Phosphotyrosine protein) phosphatases II 115-322 7.1e-43 141.7 In-house 12-172 (176) alignment 
Range on Protein: 115-322
Range on HMM: 12-172/176.0
TDYINANYIPGFnsprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDtyggslevslqseldyehwitrtfmlqknk
 ||||||.| |      .||.|||||.|. | ..|..| . |..|..|. || |. ||..|||  .. .                               
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

mkreviQLQFTSWPDHGVPEQtKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDrltqHMEDNDFVDVCGVVCEMRMHRN-YLVQTETQYI
      | ... |||||||.  . .|.... .||.....   .||.||||||.|||||..|..     .| . ...|  .....|..|  . |||. || 
......qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIHDCLMDY
|...... .
flyefelll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 81-322 6.5e-42 138.1 In-house 31-268 (281) alignment 
Range on Protein: 81-322
Range on HMM: 31-268/281.0
ATNAEVNKTKNRFNKILPYEHSRVKLMA-LKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
. |  ||. |||. .|   . |||.|   .  |  |||| ||||      | ||  |||  ||  |.|||||....| |||. . .|  ..|| .|.|..
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

KGRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnkcviKPVIVHCSAGVGRTGTYIALDRL
      .   | || .     .  .|  . |  .   | . .  .  |||  ||| .. ||  ....| |        | ..||||||||.|| .|..  
ahcclqf.dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars......tppvihcsagvgrsgtlmaveia

TQHMED-NDFVDVCGVVCEMRM-HRNYLVQTETQYIFIHDCLMDY
 | .     . |.  .|  .|.  |   |||  ||..|   |.|.
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0049772 (Phosphotyrosine protein) phosphatases II 83-322 3.3e-41 137.4 In-house 42-279 (314) alignment 
Range on Protein: 83-322
Range on HMM: 42-279/314.0
NAEVNKTKNRFNKILPYEhSRVKLMALKGKSeTDYINANYIPGFnspREYIACQGPLPETTNDM----------WRMI--WEKKSTIIVM----------
. ..|..|||. .|||.. .||.|  | ... .|||||.|. ||   . .||.||||..| .|           |||.  .. .. .|||          
dlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------MTKTVEGGkdkchqywpkkkgrsdtyggslevSLQSELDYEHWItrTFMLQKNKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVRER
            ..  ..|                        .. .. |.|..   . .  ... .|..|..  . .||...|  .. ...|.. ..| 
srLdaAlgKtpllildgng........................neptaadlellk..eelydpelferlgikylripvpDgsap.lledfdeflefieea

irnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRN-----YLVQTETQYIFIHDCLMDY
       .||.|||.||.|||||..... |  ..   . |..  .. ..|. |       ....  ||.||...|..|
....dkggpvlvHCkaGkgRtgtfvvaaylmkll...g.vsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 64-323 1.1e-40 134.4 In-house 23-271 (288) alignment 
Range on Protein: 64-323
Range on HMM: 23-271/288.0
EEYDDIQAVGSIvrmDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
 || |    .||   | ...   | |..|....   . .||||          ||.|| ..  . .|  | .| ||  | . .|.|. |.    |||...
keyrdspneasi...diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce

TVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREV--IQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIV
 .| ||.|  .|.| |.|..  .|    |  ..  | .. .. . .  ..... .|   .| .  |.|.||||. .. | ... .      | . ||..|
llekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivv

HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|.||||||||| |      . .  .||. .  .. ..| .|   .||| ||...| |.....
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
0049260 (Phosphotyrosine protein) phosphatases II 122-317 1.1e-40 134.1 In-house 1-144 (152) alignment 
Range on Protein: 122-317
Range on HMM: 1-144/152.0
YIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWpkkkgrsdtyggslevslqseldyehwitrtfmlqknkmkreviQ
.|.|.. |.|.||.|||.|.|..| |||..| . |.|||.|. .| ||.||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

LQFTSWPDHGVPEQTKPMLDFVKNVRE-RIRNKCvikPVIVHCSAGVGRTGTYIALDRLTqhmednDFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
 ... |||||||. .  .|.... ... ......   ||.||||||||||||..|.. .         |..  .|  .|..|.. |... |..|...
ylhlpwpDhgvpdlsqlllflllfieklaldkgg...pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 82-324 2.5e-40 133.2 In-house 30-271 (285) alignment 
Range on Protein: 82-324
Range on HMM: 30-271/285.0
TNAEVNKTKNRFNKILPYEHSRVKLmalKgKSETDYINANYI--PGFNSpREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
|  | |   ||.  .   | .|| |   | . . ||| |...  || .    ||. ||||||| .|.|.||...| . ..|.   .||| .||  |.|.|
tayeanpdlnryadvrcieetrvvl...k.nhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

KGRSDTYGgSLEVSLQSE----LDYEHWITRTFMlQKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVRErIRNKcvIKPVIVHCSAGVGRTGT
 |    .|   |..|       .    . . | . . .    |     ..|   |||.  ||...||... | |.. .  |   ||. |||||||||| |
lgevvkfg.kyeitlteckeeaiagtilnaltvi.ntedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpk..ekpicvhcsagvgrtat

YIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
.. .|  | .. .|  ...  .| |||  |   ||.  |..|..  ||.|| 
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 78-243 1e-38 127.9 In-house 22-190 (297) alignment 
Range on Protein: 78-243
Range on HMM: 22-190/297.0
MDQATNAEVNKT--KNRFNKILPYEHSRVKLmaLKGKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCH
 .. . |  | .  |||...|| .. .||||  |.. .|.|||||.|.  |  ...  ||  |||| .| .| |....|.   .|||..|  |.|.||| 
gesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

QYWPKKKGRSDTYGGSL-EVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||. ..   . |  . |   .   .... |   . |   . .| |   || |||||||| . . .  | 
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 62-324 1.4e-38 127.4 In-house 24-288 (305) alignment 
Range on Protein: 62-324
Range on HMM: 24-288/305.0
LMEEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
| .|.  .. .  . .|    .|. .. |||.  .   .. ||||   .|    .|| |||.     |. .| .| || .|  |.| | ...|   | |.
lraefvamkrfndfekmkafkeaq.eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

TKTVEGGKDKCHQYWPKKKGRSDTY---GGSLEVSLQSEL------DYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERi
 . .| |  ||..|.. |..   ..   |  . | ..|        | .  .|.| ..     . .| | .  .  ||| |||     .|..... |   
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.

rnKcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFV-DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
  |    |..||||||.||||. . |. . . .   . . |   ..  .|  ||  .||..||.|.|. ...|| 
..k...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0044763 (Phosphotyrosine protein) phosphatases II 98-320 1.5e-37 124.3 In-house 1-168 (178) alignment 
Range on Protein: 98-320
Range on HMM: 1-168/178.0
PYEHSRVKLMALKGKSETDYINANYIPGFnsprEYIACQGPlpettNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGrsdtyggslevslqse
|....||.|. | |   .|||||..| ..     |.....|      | .....| . | ||..|...|.|. ||..|||.. |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

ldyehwitrtfmlqknkmkrevIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI-RNKcviKPVIVHCSAGVGRTGTYIALDRLTQHmedndFVDVCGVVC
                      || ... .||||||. .. .|.||. ..| . ...   .||.|||||||||.|| .|.. . ..      ...  .. 
......................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

EMRMHRNyLVQTETQYIFIHDCLM
..|..|.  |... |. ..... .
lvrerRp.ivpnpgqlrqLyefel
0051082 (Phosphotyrosine protein) phosphatases II 115-319 1.2e-36 120.9 In-house 3-149 (151) alignment 
Range on Protein: 115-319
Range on HMM: 3-149/151.0
TDYINANYIPGFnspreYIACQGPLPettnDMWRMIWEKKSTIIVMMTKTVEGGkdKCHQYWPKKKgrsdtyggslevslqseldyehwitrtfmlqknk
.||||..|. |.     .....|||.    | .....| . . ||......| |  .|..|.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

mkREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcV-IKPVIVHCSAGVGRTGTYIALDRLTQHmedndfVDVCGVVCEMRMHRNYLVQTETQYI
  .||.......|||.|.|. .. .|.|.. ...         .||.||||||.||||| .||... ..      |..  .. |.|..| ..||...|..
..ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FIHDCL
|.. .|
fqlfal
PTPc_DSPc_SM00012 219-320 5.7e-35 115.1 In-house 2-104 (105) alignment 
Range on Protein: 219-320
Range on HMM: 2-104/105.0
VIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
| ....|.||||||||.....|.....|..  ...   |||.||||||||||||..||| | |..|.. ..||.. .|.|.|..|. .||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLM
.|.
all
subfamily_CG42327_pd Subfamily CG42327 62-251 1.4e-34 114.2 In-house 7-195 (319) alignment 
Range on Protein: 62-251
Range on HMM: 7-195/319.0
LMEEYDDIQavGSIVRMDqaTNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVM
..||..|.     | | |        | |.|. ...|  ..|| |     . .. |..|.|. |.. .|  |||.| .| ... |.||..||..| .|| 
vaeefrdlP..qliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

MTKTVEGGKDKCHQYWPKKKGRSDT-YGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFtSWPDHGVPEQTKPMLDFVKNVRERIR
.|.  | | ..| .|.| |..  .|   | . |.|.     ..... |..|..  ... ||.    .  |.. .|| . ....  . .||. ..
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 87-322 3.8e-34 112.6 In-house 52-289 (310) alignment 
Range on Protein: 87-322
Range on HMM: 52-289/310.0
NKTKNRFNKILPYEHSRVKLMALKGKSEtDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkKGRSDTY
.  |||.  ..  . |||||   | . | ||| |||.        .| .||||  |  |.||||.....  |... |..| |. ||  |||   | ..||
ymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtety

GgSLEVSLQSELDYEHWI---TRTFMLQK-------NKM-KREVIQLQFTSWPDHGVPEQTkpmldfVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIA
|  . |.  ||   |  |   . ||. ..        .. .  |  ...  ||| |||..       .. | .|.  .    |..||||||..|... .|
g.cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvrhgpcvvhcsagkdrlyvvva

LDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|.   ....  . ||.  |. |.. .|   .||| ||..|.   . .
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 82-314 7.4e-34 111.8 In-house 45-272 (301) alignment 
Range on Protein: 82-314
Range on HMM: 45-272/301.0
TNAEVNKTKNRFNKIlPY-EHSRVKLMAlKGKSEtdYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKK
..| ..| |.|.... |   .. |.... .||     | ||.||    |. .|| ||||..|..|.| |.   .   |||....||  ..||..| | | 
syaylpkdkhryptv.PckPstaveviv.dGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

GRSDTYG-GSLEVSLQSELDYEHWITRTFMLQKNK---MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIAL
...   |  ....  .  .  .. . ||. ..        | |.  |...|.|.|||.    . |... |..        ||..||||||.||. ..|. 
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiGrsvafigt

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
. |....| .  ...   . ..| ||   |||..|  .
eylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_egg_pd Subfamily egg 80-323 9.6e-31 101.6 In-house 34-270 (307) alignment 
Range on Protein: 80-323
Range on HMM: 34-270/307.0
QATNaEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGgkDKCHQYWPKK
.| . . |..| | ...   . |||||   .|.   |.| ||.. |     |.| .| || .| .|.|||.....   |||.| ..|   ..|. |||| 
taas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

KGRSDTY-GGSLEVS---LQSELDYEHWITRTFMLQKNkmkREVIQLQFTSWPDHGVPEQTKPMldfvkNVRERIRNkcVIKPVIVHCSAGVGRTGTYIA
.  |  .  |||..    ..|. |    .|.  ..  .   .|   |.   .  . . .   |.     .|  ..||  . |||.|..  || ...| .|
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdvnnssdvyspl.....rvlrklrn..lskpvvvqdilGvskaatlva

LDRLTQHMEDNDF--VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
..    ..         |   |  .|..|.. |..  .|.|..  .. .|
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 64-325 1.2e-29 98.0 In-house 23-278 (312) alignment 
Range on Protein: 64-325
Range on HMM: 23-278/312.0
EEYddiQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkGkSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
 ||   .||| ||   . |     |  ||. .|  ..  |  |    |  |  || ||..     |  ....|||| .|.  .|..     || |.... 
key...kavgnivsdsectaflkfkdlnrypniqcwdrgrftla...g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

TVEGGKDKCHQYWPKKKGRSD--------TYGGSLEVSLQSELDYEHWITRTFMlQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirNKcv
 || | .|| .|     |  |         |   .|.  .|     | . .  . .    .  . . |..||||||.|.     | ..  |.    .|  
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvv.katgqesklnhyqwaswpdhgmpdscdtalrllsavkk...dk..

iKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
 |||| ||||||||||| . .. .   .      .|  .   .|  |   |..  ||..   |..... |
.kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 87-179 5e-27 89.5 In-house 47-153 (350) alignment 
Range on Protein: 87-179
Range on HMM: 47-153/350.0
NKTKNRFNKILPYEHSRVKLM-AL-------KGKSETDYINANYIP------GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKC
  .|||.. |||||||||||  .|       .  |  |||||||.         |.   ||| |.|||.| .|....| . | ..|...|. || . .||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HQYWPKK
..||.. 
yrYWqeg
0048076 (Phosphotyrosine protein) phosphatases II 185-322 7.6e-27 89.2 In-house 11-142 (145) alignment 
Range on Protein: 185-322
Range on HMM: 11-142/145.0
TYGGSLEVSLQSELDYEHWITR--TFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDRLTQh
 | ||| . |. ||  .. ||.  ...  ..  .|..||.....|||||||. .. .|.|.. ..| ....   .||.||||||||||||..|.. . . 
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll.

medNDfVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
   .. |..  .. ..|..| . |... |..|...... .
...lg.vsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 193-317 1e-25 85.5 In-house 23-139 (144) alignment 
Range on Protein: 193-317
Range on HMM: 23-139/144.0
SLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDRLTqhmeDNDfVDVC
 |  .|.  ..|. |    .. ..||.||.....|||||||. .. .|.|.. ..| ....   .||.||||||||||||..|....      .. ... 
ellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtgtlvaaylmk....klg.lsle

GVVCEMRMHRNYLVQTETQYIFIHD
 .. ..|..| . |... |..|...
ealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 138-319 9.4e-25 81.7 In-house 99-284 (302) alignment 
Range on Protein: 138-319
Range on HMM: 99-284/302.0
PLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGG------SLEVSLQSELDYEHWITRTFMLQKN----KMKREVIQLQFTSW
|  .|..  | .| . . .|.| ... ||... || .|. .| |   ..|       |..  |.   | ..    |  .. .    |.|. |  |.|..|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPEQTKPMLDFVKNVrErirnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
|||| |..... || .|   |     .  | |.|||||||||||| .|.    |    ..  |.  .|. .|  |   ||.|.| |..  |.
pdhGapkeaytaldilkfc.e.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 129-316 9.7e-24 78.6 In-house 4-197 (199) alignment 
Range on Protein: 129-316
Range on HMM: 4-197/199.0
PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK----MKREVIQLQF
 | |||.| || ||  |.|.|.||  |  |||.       .     |||  .  .  || || |. ..      .   ...| .|       ||. . ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPEQTKpMLDFVKNVRERIRNKC--VIKPVIVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
||| ..  |. .  .. ||   ||  ..       ||||||| | | || ..|||   . | |     ||.  |   .|  |  .. .  .| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 130-316 1e-23 78.6 In-house 4-196 (198) alignment 
Range on Protein: 130-316
Range on HMM: 4-196/198.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK----MKREVIQLQFT
| |||.| || ||  |.|.|.||  |  |||.       .     |||  .  .  || || |. ..      .   ...| .|       ||. . |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPEQTKpMLDFVKNVRERIRNKC--VIKPVIVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
|| ..  |. .  .. ||   ||  ..       ||||||| | | || ..|||   . | |     ||.  |   .|  |  .. .  .| ||.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 215-324 1.1e-21 71.7 In-house 87-195 (440) alignment 
Range on Protein: 215-324
Range on HMM: 87-195/440.0
MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
  | . | .. .|||.|||. . |.| ....| |  ..|.   |..||||||.||||  ||.| . .. . .| .|.  ..  ||  |  .|||  || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHDCLMDYFC
.|..... . 
vheavlegll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 99-318 3.6e-21 70.6 In-house 30-254 (290) alignment 
Range on Protein: 99-318
Range on HMM: 30-254/290.0
YEHSRVKLMALKGKSETDYINANYIPgFNSPREYIACQGPLPET-------TNDMWRMIWEKKSTIIVMMTKTVEGGKD----KCHQYWPKKKGRSDTYG
 |..|| |   . .   ||| ||..  . .  . |. | |. ..        .. | |. . |.. .||. .  |  ..     | .| |.. | . ...
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

GsLEVSLQSELDYEHWITRTFMLQKNKMKR-EVIQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIVHCSAGVGRTGTYIALDRLTQHME-D
| |.|. .|    .  .||. ... .. .   |   .. .| .  |.|.|| .|. ...|      |.   ||||||  |. |  .  |..   | .   
g.ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkv......kasktpvivHcvdGiSrsAalaaiilgyQkiaet

NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDC
.. | .  |. ..| .|. ........ |.   
sgsvkledvlkalrkqralaitsalelafvdag
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 87-178 5e-19 62.8 In-house 48-155 (349) alignment 
Range on Protein: 87-178
Range on HMM: 48-155/349.0
NKTKNRFNKILPYEHSRVKLMA-LK-------------GKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKD
  .|||...|||||||||||   ||             .    |||||||.  . ..  . ||| | ||| | .| ...|  ..  ... ...  | . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHQYWPK
||..|| .
kcdiywqe
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 86-321 1.9e-18 61.1 In-house 46-277 (303) alignment 
Range on Protein: 86-321
Range on HMM: 46-277/303.0
VNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIpGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
 |  ||||  ..  .||.|||      |.. || |.|.  ..| .  |  | ||. |. |.|.|| |.|   ....    |  |   .  .|...   . 
knmdknrfvdvicldhskvkl......sdssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

YGGSLEVSLQSELD-YEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKP-MLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALD--RLTQ
   |. |    ...  . |  .   . . . |  .   .. .||   .| .. | ..  . ...  .|. .  .| .    .|.||.||.  ..   |. 
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

HMEDNdFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
| |..  .|.  ..  .|  | . ||  .|. ...  | .
hseqa.sldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_eak_pd Subfamily eak 49-244 2e-17 57.6 In-house 18-205 (332) alignment 
Range on Protein: 49-244
Range on HMM: 18-205/332.0
THYDWLKADSEHRLMEEYDDIQAVGSIVRMdQATNAeVNktKNrFNKILPYEHSRVKLMALKgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWR
  . | . .    .....|| | . ||    . ..| ||  .|   ||.||..  |.| . . . .  ||||  .   .  |.||    .  .    .|.
knhiwnrinqrinivadlddyqrllsiset.arlea.vn..rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwq

MIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTkPMLDFVK
|. |.||  ||.. . || . .|  .|.|.| .|     | |.|  .. .  .   || ..|.|     .|   ..  | .  .|     .| . |
mvleqkspaivqlledvelkleksdkyfpdk.treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye.dflalrk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 142-322 9.7e-17 55.9 In-house 40-220 (255) alignment 
Range on Protein: 142-322
Range on HMM: 40-220/255.0
TTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSelDYEHWITRTF----MLQKNKMKREVIQLQFTSWPDHGVPEQTK
| . ....|  .|.. .||..   | |..||..|.| .|     .   ..|.        . . ||     .| . |  ..|   ... |...  ||...
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PMLDFVKNVRErirnKcviKPVIVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
 .|  .| ||.        |.|.||||.|.||. ...  . . |     ..  . |  |   .. |.| .|.  ..|  |  |    ..|.
eilnilkvvrd....s...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 218-323 2.3e-16 54.5 In-house 216-344 (350) alignment 
Range on Protein: 218-323
Range on HMM: 216-344/350.0
EVIQLQFTSWPDHGV---PEQTKPMLD-----FVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ-----HMEDNDFV---------D-VCGV
.| |||.  |.| ..   ||.  ..|.       ... |   ..   .|..||||||||||||...|| | .     ..  ....         | .  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VCEMRMHRNYLVQTETQYIFIHDCLMDYF
| |.|  |  .||. .|.|||...|. ||
vnelrkqrismvqnldqfifiYeallfyf
subfamily_hpo-7_pd Subfamily hpo-7 141-323 5.4e-15 50.0 In-house 45-227 (263) alignment 
Range on Protein: 141-323
Range on HMM: 45-227/263.0
ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDyeHWITRTFML----QKNKMKREVIQLQFTSWPDHGVPEQT
.| . ....|  .|.. .||..   | |..|| .|.| .|     .   ..|.     .    . .|  |    .. |  ..| . ... |...  ||..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

KPMLDFVKNVRErirnkCviKPVIVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. .|  .| .|.        |...||||.|.||.  .   . . |     ..  . |  |   .. |.| .|.  ..|  |  |    ..|..
reilnilkvarn.....s..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_CG42327_pd Subfamily CG42327 247-322 9.5e-15 49.1 In-house 238-314 (319) alignment 
Range on Protein: 247-322
Range on HMM: 238-314/319.0
RERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
  |  ..    |..|||| ||||||. || |   ...|..   ||.  .|  .|  |   |.|  || ||.  |  |
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 260-321 2.7e-14 47.3 In-house 2-63 (69) alignment 
Range on Protein: 260-321
Range on HMM: 2-63/69.0
IVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
.||||.| |||||.||.      .  . .||.   |  ||  |  .|  | .|||||| |..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 78-231 1.3e-13 45.2 In-house 88-234 (244) alignment 
Range on Protein: 78-231
Range on HMM: 88-234/244.0
MDQATNAeVNKTKNRFNKILPYEHSRVKLMalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKtVEggkdKCHQYWP
| .| |   |  |||    ||.. .|| |   ||     |||| ..  .    |||  | || .|. |.|.|. |..  ..|..   ||    .  .|||
mkdafnp.nnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.ve....eedeywp

KKKGrSDTYGGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHG
  .   . |   . |.|    ..    .  . ..   |. .. .  .| . ||  |
dsep.lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 260-321 1.5e-13 44.9 In-house 1-62 (69) alignment 
Range on Protein: 260-321
Range on HMM: 1-62/69.0
IVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
.||||.| |||||.||.      .  . .||.   |  ||  |  .|  | .|.|||| |..
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 217-323 4.7e-12 39.9 In-house 218-344 (349) alignment 
Range on Protein: 217-323
Range on HMM: 218-344/349.0
REVIQLQFTSWPDHGVPEQTKPMLDFVKnVRE---------RIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ--HMEDNDFVDV----------CGVV
 |..|||.  |.| ..    . .|  .. |..            ..    ...|||||| ||||... || | .  ..  |... .            .|
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

CEMRMHRNYLVQTETQYIFIHDCLMDYF
 |.|  |  .||  .|.|.|...|. ||
nelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 41-137 3.2e-11 37.2 In-house 4-95 (95) alignment 
Range on Protein: 41-137
Range on HMM: 4-95/95.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPREYIACQG
|. .. . .|   ....|.. . .|.  |.          .  .| |  |||| .|.||. .||   .|  | ..||||| .. |.     |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapy..tvgsseanipknrflnifpydatrv...vlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 97-232 3.9e-11 37.4 In-house 3-126 (130) alignment 
Range on Protein: 97-232
Range on HMM: 3-126/130.0
LPYEHSRVKlmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKtVEggkdKCHQYWPKKKgRSDTYGGSLEVSLQS
|..| ||..        . .||||...   .  .||.  | || .|. |.|.|. |.   ..|..   ||    .  .|||  .   . |   . |.|  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.ve....eedeywpdse.Plewyeediivtltd

ElDYEHWITRTFMLQKNKMKR---EVIQLQFTSWPDHGV
  |  . |  ...  ......    .  .| . ||  | 
r.defknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 40-128 4.7e-11 36.7 In-house 4-88 (440) alignment 
Range on Protein: 40-128
Range on HMM: 4-88/440.0
RPVLLANIethYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNS
||...|..    |... .   | .|.   .   |   .  . ..   || |||. .|| |.|||| |  .||  ..||||| || | .|
rpiivadf...adyvqnnrrsrafedewsllpsgls.qpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 258-319 1.2e-10 35.8 In-house 230-291 (297) alignment 
Range on Protein: 258-319
Range on HMM: 230-291/297.0
PVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
...|||||||||.|  .  | . . .  .   ||  ..  .|  |  ||||  |. ...|  
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 82-180 2.3e-10 33.7 In-house 22-88 (169) alignment 
Range on Protein: 82-180
Range on HMM: 22-88/169.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtktveGGKDKCHQYWPKKK
..  .|.||||    |   | ||||  .  .  .|||||                           |||||  ...||..     |. |   ..||.|.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 82-180 2.9e-10 33.2 In-house 21-87 (169) alignment 
Range on Protein: 82-180
Range on HMM: 21-87/169.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtktveGGKDKCHQYWPKKK
..  .|.||||    |   | ||||  .  .  .|||||                           |||||  ...||..     |. |   ..||.|.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpeke
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 87-170 4.8e-10 33.4 In-house 34-116 (332) alignment 
Range on Protein: 87-170
Range on HMM: 34-116/332.0
NKTKNRFNKILPYEHSRVKLMALKGKSetDYINANYIPGFNSPREYIACQGPLPETTND-MWRMIWEKKSTIIVMMTKTVEGGKD
|   ||  ..  ..||||.|    ||   |. ||... |..    || .| |. . |.  .|||. |.| ..|...    |  | 
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_PTPDC1_pd Subfamily PTPDC1 208-317 9.4e-10 33.2 In-house 71-170 (182) alignment 
Range on Protein: 208-317
Range on HMM: 71-170/182.0
FMLQKNKMKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVRERIRNKcvikPVIVHCSAGVGRTGTYIALDRLTQHMedndfVDVCGVVCEMRMHRNYLVQ
|  ........ |     .|.|.||.  .. .|| || |   ....     | ||| || ||||  ||   . ..      ..    .  .| .|   .|
fsYdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg....kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiq

TETQYIFIHD
| .|  ....
treqvelvke
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 85-162 1.1e-09 32.2 In-house 35-117 (347) alignment 
Range on Protein: 85-162
Range on HMM: 35-117/347.0
EVNKTKNRFNKILPYEHSRVKLMALKGKS-----ETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMT
| . .||| ..    . .|| |   | |         |||| .|   |. .|||  | |||.|  |.|.|.   | | .| . 
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 224-323 1.4e-09 31.8 In-house 188-285 (302) alignment 
Range on Protein: 224-323
Range on HMM: 188-285/302.0
FTSWPDHGVPEQTKPMLDFVKNVreRIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.| |... ||..   .   ...|    ..  . .....    |.|| |. ..|    ....... . .  .|  .|  |   |.. .||.... .|. |.
ltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
0038934 (Phosphotyrosine protein) phosphatases II 211-276 1.6e-09 33.2 In-house 71-135 (194) alignment 
Range on Protein: 211-276
Range on HMM: 71-135/194.0
QKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrNKCVIKPVIVHCSAGVGRTGTYIAL
 ......  |.     .||.|.. ... .|.|.. | | . |..  . | ||| ||.||||| .| 
dpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaa
PTEN_1 216-301 6.2e-09 30.9 In-house 92-173 (196) alignment 
Range on Protein: 216-301
Range on HMM: 92-173/196.0
KREVIQLQFtSWPDHGVPEQTKpMLDFVKNVRERIRNK-CvIKPVIVHCSAGVGRTGTYIAlDRLTQHMEdNDFVDVCGVVCEMRMH
|. |..|.| ...|||.|   . ..|..|.. | .... .  . |.||| ||.||.|| .|   | ...   .. . .  |.|.|..
ksgveylhf.pieDhgapslse.lfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva.ayLmykgk.ltadeAlelvrekRpp
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 171-322 1.6e-08 28.4 In-house 149-301 (332) alignment 
Range on Protein: 171-322
Range on HMM: 149-301/332.0
KCHQYWPKKKGRSDTYGgsleVSLQSELDYEHWITRTF--MLQKNKMKREVIQLQFTSWPDHG-VPEQTKPMLDFVKN--VRERIRNKCVIKPVIVHCSA
 |...||.|. . |       .|.|.  |.     .||   . ..|  .. . ..|  | |   .||    |   .|   .|   .   .| |... |..
icrkfwpekrskkdfpa....lsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|| .   . ..| .  .. ..  | .   .  ..|.|   ..|   |    . || .
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 58-187 1.3e-07 25.3 In-house 24-149 (302) alignment 
Range on Protein: 58-187
Range on HMM: 24-149/302.0
SEHRLMEEYDDIQAVGsiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMAlkgkSETDYINANY--IPGFNspREYIACQGPLPETT---NDMWRMIWE
 . .. .|.. |...   | ... .    |  ||. ...  ... .||| |    .. .|.||    .| ..  |. |  | |  ...   .. |||...
dtaevkkefkkidtmk..vdlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfq

KKSTIIVMMTKTVEGGKdKCHQYWPKKKGRSDTYG
.| . .|.. .. |  |   ....||| |   .||
ekivsvvilvgeeelkk.tlselfpkksgdykeyg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 82-126 1.7e-07 25.1 In-house 32-77 (244) alignment 
Range on Protein: 82-126
Range on HMM: 32-77/244.0
TN--AEVNKTKNRFNKILPYEHSRVKLMALKgKSETDYINANYIPGF
||    .| ||||. .|||....|| | . | |  .|||||||| | 
tnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs
subfamily_PTEN_pd Subfamily PTEN 211-312 2.6e-06 22.5 In-house 74-169 (184) alignment 
Range on Protein: 211-312
Range on HMM: 74-169/184.0
QKNKMKREVIQLQFTswpDHGVPeQTKPMLDFVKNVRERIRNKCvIKPVIVHCSAGVGRTGTYIALDrLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTET
...|.. .|....|.   ||  | . . . ..|..... . ..   . |.||| || ||||. |.   | ...  ..  ..  .  |.|.. .  |.   
dskkfdgrvavypfd...Dhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPs

QY
| 
qr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 130-188 4.2e-06 20.3 In-house 236-290 (440) alignment 
Range on Protein: 130-188
Range on HMM: 236-290/440.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEggkDKCHQYWPKKkGRSDTYGG
  .|| | ||  |  |.||.. . . . |.|. .  .     |  ||| .  || |.| 
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvn.trsvtfgp
subfamily_VSP_pd Subfamily VSP 227-275 4.9e-06 20.6 In-house 101-147 (212) alignment 
Range on Protein: 227-275
Range on HMM: 101-147/212.0
WPDHGVPEQtKPMLDFVKNVRERIRNKcVIKPVIVHCSAGVGRTGTYIA
  || ||.  . .| | |.|.| . .    . ...||  | ||||| . 
iddhnvpkl.eellvftkevkewlekd.lknvlaihckGGkgrtGtivc
PTPc_motif_SM00404 193-275 7.4e-06 20.9 In-house 21-99 (140) alignment 
Range on Protein: 193-275
Range on HMM: 21-99/140.0
SLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIVHCSAGVGRTGTYIA
 |...|. .| |  |   .  |.. .....|..        . .. . .|||..|.      .   . |.||| ||| |..| |.
allkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatlii