Gene PTPRB-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP068_AA protein Get Run
SpurP068_AA_44-324 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 39-325 4.3e-138 454.3 In-house 4-287 (293) alignment
Range on Protein: 39-325
Range on HMM: 4-287/293.0
SRPVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQATNAeVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGP
|.|. | ..|.|.. .||||..|..|||....|||.   ...|..| ||..|||...||||.||||||.|||..|..||||||||||.|||||.||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaela.vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKP
||||..|.|||.|||||.||||.|..||.|| ||..|||...  .... |...|.|..| ..|.|..|.....|.|..|.| |..|||||||||||.||.
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade..epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektkt

MLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
.||||..|||.|....  .|..||||||||||||.||||||.|..|..|.||..|.|.|.|..||.|||||.||||||.|..|.. .
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_PTPRD_pd Subfamily PTPRD 40-326 9.7e-115 379.3 In-house 3-284 (564) alignment
Range on Protein: 40-326
Range on HMM: 3-284/564.0
RPVLLANIETHYDWLKADSEHRLMEEYDDIQAVgSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPL
.|.  |....|.  |||.|. ...||| .|.   . .....| |...|| |||...|..|.||||.| ...|....|||||..| |......||| ||||
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaa.nkpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTK
.||..| |||.||..|..|||.||..| ||.|||.|||.| | . || |.|.|.|..| .... . ||| |.  |.. .||| | .|||||||||||...
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesat

PMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
..||....||.    ..  .|..||||||||||||.|..| . . ..... ||. ..| ..| .||..||||.||||||. ....  .|
slLdlirkvraln..epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 45-327 8.1e-100 328.9 In-house 5-284 (318) alignment
Range on Protein: 45-327
Range on HMM: 5-284/318.0
ANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTN
 ..|.|   |... |  | |||. .. . . |   .. . .|||.|||.. ||.|.|.||||  |.|. ..||||||||.|... ..|||.|.||||| .
edleshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKM--KREVIQLQFTSWPDHGVPEQTKPMLDF
|.|||.||..|..|||.|...| ||.|.|.|||.|.  | .| |.| | |..|....... |.| ......  .|.| | ..|||||.||||..  .||.
DfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsy.gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

VKNVrERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSGV
|..| ... .|.  .|..|||||||||||..||.| | ......  ||| ..| ..| .|| .|||| ||.||.| |...  || 
vrqv.skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 44-321 6.4e-97 319.1 In-house 6-277 (288) alignment
Range on Protein: 44-321
Range on HMM: 6-277/288.0
LANIeTHYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETT
. .. ..    .|...  . |||. . |...  . ..|..  ||..|||.. ||||.. ||||  |. ....|||||.|| | .. ..||| ||||..| 
ispv.akvakksarnrtgfseeynsLaalekt.ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtv

NDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
|| |....|.|.. |||.|. ||||| ||..|||... .   | ||..| |... . |....|...|.|.| ..|. |.|...||||||||...|.|...
ndfWelvyenktstivmltelveggktkCeeYWPdad.kpkny.GsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllell

KNVRERIRNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
..|     ..   .|.|||||||||||||.|||| | ...| .|..||.|.|...|..|. ||||..||.||...|..
rqvkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

0050432 (Phosphotyrosine protein) phosphatases II 48-324 7.6e-95 313.0 In-house 30-300 (308) alignment
Range on Protein: 48-324
Range on HMM: 30-300/308.0
ETHYDWLKADSEHRLMEEYDDIQAVGSiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLmalkgKSETDYINANYIPGF--NSPREYIACQGPLPETTND
. .. . ||.. ..|.||. ....|   ..   ... . ||.|||.  ||||.||||||     ....|||||.|..|.  ..||..||.|||||.|..|
dllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntved

MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||.|| ....|||.||.|| |. ||.|||| . |.. .. | . | | ||  ......||..|..  ..  |.| ....|.|||||||......|||.
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfl

KNVRERIRNkcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
. ||.....    .|..||||||||||||.|||| | ...| .  |||...|. .|..|.. |||. ||.|....|..|. 
elvrkslpg....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0051299 (Phosphotyrosine protein) phosphatases II 43-323 1.3e-94 312.2 In-house 6-286 (288) alignment
Range on Protein: 43-323
Range on HMM: 6-286/288.0
LLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPET
 . ... .. .|.|.. ..|.||.......   .    |.. . |..|||.  ||||.||||||  |.| ...|||||.||.|.|..|..||.|||||.|
sveellklvlkllangltglleefeellsllpdlt.lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

TNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWPDHGVPEQT
..| |||.||.....|||.||.|| |. ||.||||   | | |||  . | | ||  ......||....      ... .|.|.....|.|||||||. .
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

KPMLDFVKNVRERIRnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
...|||.. ||. ..     .||.||||||||||||.|||| | ...| .  |||...|. .|..|...|||. ||.|....|..|.
ellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 48-323 2.6e-94 310.4 In-house 3-276 (281) alignment
Range on Protein: 48-323
Range on HMM: 3-276/281.0
ETHYDWLKADSEHRLMEEYDDIQAVGsIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMW
..| . |...... ..|||....|.| .    .|..|. |..|||.. |  |...|||.   . ...|||||||..||.....||||.|||.|.. ...|
rkhlkqlsqndnaGfieeyeklaaig.vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGGSLEVSLQSELDYEHWITRTFML-QKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNV
.|.||.| ..|||.|. .|.|| |||.||| ..  |..  | . |. ..| . ...|.|.|.| ...  .||| ||..|.|||||||..|| .|.| |.|
qmvweqkvsaivmvtreieagklkChrYWPddn..selkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkev

RERIRNKCViKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
..  ..|    |...|||||||||||||||||| ...|..   .||. || |.| .||..||| .|| |..  ..|..
lkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

0046845 (Phosphotyrosine protein) phosphatases II 62-324 7.4e-93 306.3 In-house 2-275 (284) alignment
Range on Protein: 62-324
Range on HMM: 2-275/284.0
LMEEYDDIQAVGSIVR-MDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGF-----NSPREYIACQGPLPETTNDMWRMIWEKK
|.||.  .. .   .     ..... |..|||.  ||||.||||||  |.|. ...|||||.|..|.     ......||.|||||.|..| |||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIR
...|||.|..|| |. ||.|||| . | . |||. . | | ||  ......||..|..   ..  |.|.....|||||||||......|.|.. ||| ..
vrvIVmltelvengrekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

NKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDND---FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
|    .|..||||||||||||.|||| | ...| ..    |||...|. .|..|.. |||. ||.|....|..|. 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0040438 (Phosphotyrosine protein) phosphatases II 47-323 6.1e-90 297.0 In-house 5-276 (317) alignment
Range on Protein: 47-323
Range on HMM: 5-276/317.0
IETHYDWLKADSEHRLMEEYDDIQAVGSIvrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
.. .. .|.. . ..|.||. |.. .       . .. ..|| |||.  ||||.||||||  |.|  ..|||||.|..|.| .|..||.|||||.|..| 
lllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||.|| ..|.|||.|...| |. ||.||||   | . || | . | |.||  ..... ||....  ... .|.| ....|.|||||||. ....|||..
wrmvweqgvtvivmLteleelgrekcaqYwpl..getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

NVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
 ||| ....   .||.||||||||||||.||.... ...| . .|||  .|.|.|..|.. |||. ||.|..|.|..|.
avrealedpg..gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_PTPRG_pd Subfamily PTPRG 46-325 7.1e-90 296.8 In-house 5-289 (563) alignment
Range on Protein: 46-325
Range on HMM: 5-289/563.0
NIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMD-QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSET-DYINANYIPGFNSPREYIACQGPLPETT
. . |   |.||..... ||....|       .| ...... || |||  .|..|..|||||  | || .. |||||||| |..  ...|| ||||..|.
efakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtf

NDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--------MKREVIQLQFTSWPDHGVPEQ
.| ||||||....||||.|. || |. ||..||||    | ||| .|.| |..|       .||..... |         ...|.| ..|.||||||||.
ddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetyg.alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

TKPMLDFVKnvRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
. | | |||  ..   ||  . |..||||||||||||||.|| |.. ..... |.| |..  .|..||.||||| ||||.|| |..   |
slpvLifvk..kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

0047943 (Phosphotyrosine protein) phosphatases II 53-323 9e-90 296.1 In-house 5-272 (273) alignment
Range on Protein: 53-323
Range on HMM: 5-272/273.0
WLKADSEHRLMEEYDDIQAVGSiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|.||..... .   .   .... . ||.|||.  ||||.||||||    | ...|||||.|..|.|..|..||.|||||.|..| |||.||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

KKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI
.....|||.|..|| |. ||.|||| . |   .. | . | | ||  ......||..|..  .. .|.|.....|.|||||||......|.|.. ||. .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

RN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
..   .   .||.||||||||||||.|||| | ...| .  |||. .|. .|..| . |||. ||.|....|..|.
ealpsn...gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 53-323 3.2e-89 294.4 In-house 6-277 (297) alignment
Range on Protein: 53-323
Range on HMM: 6-277/297.0
WLKADSEHRLMEEYDDIQAVGSIVRMDQATNAeVNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|..|..... .  .  .. | .   |..|||.  ||||.|.||||    .....|||||.|..|.. .|..||.|||||.|..| |||.||
lekllflalllkefeellpllllgslsvallp.enleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

KKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELD--YEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE
 ..|.|||.|. || |. ||.|||| ..| | || | . | |.|.    ......||. ...  |. .|.| ....|.|||||||| ....|||.. ||.
qnvtvIvmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

RIRN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHME---DNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
....   .   .||.|||||||||.||.||.| . | .|    .  ||.. .|...|..|.  |||. ||.|....|....
vlkllpsg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0039614 (Phosphotyrosine protein) phosphatases II 45-323 6e-89 293.7 In-house 17-289 (297) alignment
Range on Protein: 45-323
Range on HMM: 17-289/297.0
ANIETHYDWLKADSEHRLMEEYDDIQAVGSivRmDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGFNS-PREYIACQGPLPET
  .. .. ..||.| ..|..|. ... .         .. ..||.|||.  ||||.||||||  ..|   ..|||||.|..|..  .|..||.|||||||
svldlllllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

TNDMWRMIWEKKSTIIVMMTKTVEGGKdKCHQYWPKKKGrsdtYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDF
..| |||.|| ..|.|||.||.|| |. ||.|||| . |    . | . | | ..  ......||. ...|.  |.| ..|.|.|||||||. .. .|.|
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllef

VKNVRERIR---NKcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.. |||...   ..   .||.||||||||||||.||.... ...| .  |||  .|.|.|..|.. |||. ||.|..|.|....
lelvrealaelpkg...gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 41-324 3.2e-88 290.8 In-house 4-284 (319) alignment
Range on Protein: 41-324
Range on HMM: 4-284/319.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNaEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.. ........  |.. .|. | .|. ...  ..   .|.|.. | ||.|||.. ||.|...||.|..|.|. ..|||||..| |..  ...|| |.|| 
eievqeLkerlkalastgetllekefkllkeavnd.tfdsask.eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGrsdTYGGSLEVSLQSELDYEHWITRTFMLQK--NKM-KREVIQLQFTSWPDHGVPEQTK
.|..|.|||.||..| |.||.|| || .| |...|||...    . .| | | |..|   |..| | ..|.|  ...  ||| . |.|.||||.|||...
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenf...eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

PMLDFVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
 .||..|..|.  |.|   .|..||||||||||||.|.||   .... .  .||  .| ..|. || .||.. ||.||.. |...  
slldllkrirks.rektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

0045450 (Phosphotyrosine protein) phosphatases II 42-323 9e-88 290.2 In-house 9-304 (307) alignment
Range on Protein: 42-323
Range on HMM: 9-304/307.0
VLLANIETHYDWLKADSEHRLMEEYDDIQAVGSI-VRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYI--------PGFNSPRE
. . ... ..  |..|. ..| .|. ... |  . .    ... ..||.|||.  ||||.|.||||. |.|. ...|||||.|.        .|....|.
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

YIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGsLEVSLQSELDYEHWITRTFMLQ---KNKMKREVIQLQFTSWP
.||.||||||| .| |||.||...|.|||.|..|| |. ||.|||| . | . |||  . | | ||  ..... ||. ..   .... |.|.....|.||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPEQTKPMLDFVKNVRERIRN---KcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|||||. ....|||.. ||. ...   .   .||.||||||||||||.||.. . ...|..     ||.  .|...|..|   ||.. ||.|....|...
dhgvppsfeelldfieevrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

F
.
l

DSPc_SM00195 64-323 7.4e-87 286.4 In-house 4-262 (263) alignment
Range on Protein: 64-323
Range on HMM: 4-262/263.0
EEYDDIQAVGSIVrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
||......  |     . .. . ||.|||...||||.|.||||   ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

TVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcvIKPVI
 .| || ||..|||...|.. |.| ...| |...  .. ..|.||. |.|..   .|.| |.|...|||||||..||..|.... |... ...   .|..
eeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
||||||||||||....| . ...|... ||.. .|.|.|..|  .|||..||.||......|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 64-323 7.4e-87 286.4 In-house 4-262 (263) alignment
Range on Protein: 64-323
Range on HMM: 4-262/263.0
EEYDDIQAVGSIVrMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
||......  |     . .. . ||.|||...||||.|.||||   ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

TVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcvIKPVI
 .| || ||..|||...|.. |.| ...| |...  .. ..|.||. |.|..   .|.| |.|...|||||||..||..|.... |... ...   .|..
eeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
||||||||||||....| . ...|... ||.. .|.|.|..|  .|||..||.||......|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0043336 (Phosphotyrosine protein) phosphatases II 46-323 1.2e-86 285.9 In-house 6-277 (278) alignment
Range on Protein: 46-323
Range on HMM: 6-277/278.0
NIETHYDWLKADSEHRLMEEYDDIQAVGSivRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTND
... .. .|.... ..|..|. ... .     .   .. . ||.|||.  ||||.||||||  |.|   .|||||.|..|.| ||..||.|||||||..|
dllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPkkkGRSDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||.|| ..|.|||.|. || |. ||.||||   | | || | . | |..|  ......||. .   ... .|.| ......||||||||.....|||.
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggslty.gdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

KNVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
| |||.....   .||.||||||||||||.|||..| ...|.. .||.. .|.|.|..|   |||. ||.|....|..|.
kavrealedsn..gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 49-326 2.2e-84 278.2 In-house 16-293 (298) alignment
Range on Protein: 49-326
Range on HMM: 16-293/298.0
THYDWLKADSEHRLMEEYDDIQAVGSIVRMD--QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
   .  |. .  .. .|.  ...| | .. .  ...... || |||. .|.....||| | . ... |.||||| .. ...    .||.|.||.||..| 
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgrSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||..|.... |||.|...| .| |.|.|||...  ..||| ...|||.|. ..   |.|.....|.|   .||| ||.||||||.||||... .||...
WrmvteedigtiVmltnleeldktkyhkywPdeg..ketyg.eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

NVRErIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
.||   ....  |||||.|||||||.||.||.| . .... .  |||  ||  .|..|  .||||.||.||..  .... |.
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

subfamily_PTPRA_pd Subfamily PTPRA 35-326 6.3e-84 276.7 In-house 7-298 (330) alignment
Range on Protein: 35-326
Range on HMM: 7-298/330.0
KNRVSRPVLLANIETHYDWLKADSEHRLMEEYDDIQAvGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIA
 |.   |. . ..|   .  .||  ... ||.. . | |.|    .... | || |||. .||||..||| |  ..|. |.||||| .| |..   ..||
gnkkyfplpvekleeeirirsaddnklfreefnalPa.gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfia

CQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYGgSLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWP
.|||. || .|.||||||.||. |||.|.  |  ..||.||||.. | . |||  . |... |   ...  | |..|      ..| .| | |. |||||
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyG.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP

DHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
| ||| ... ||...|.|..   |.    |..||||||||||||.|.|| . . .. .  ||| ..| ..|. |  .|||. || ||.  |..|.  |
dvGvPfepiGmlkllkkvkkl..nqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg

Y_phosphatase Protein-tyrosine phosphatase 87-320 4.1e-83 273.8 Pfam-A 1-234 (235) alignment
Range on Protein: 87-320
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
||.|||...||||...||||   ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....| |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGsLEVSLQ-SEL-DYEHWITRTFMLQKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLT
||  ..| |. .|  | .....|.. |.|.| .   ||| ||..|.||||||||..|..||....|...   .   .||.||||||||||||..||| | 
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 87-320 4.1e-83 273.8 In-house 1-234 (235) alignment
Range on Protein: 87-320
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
||.|||...||||...||||   ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....| |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGsLEVSLQ-SEL-DYEHWITRTFMLQKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIVHCSAGVGRTGTYIALDRLT
||  ..| |. .|  | .....|.. |.|.| .   ||| ||..|.||||||||..|..||....|...   .   .||.||||||||||||..||| | 
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 41-326 6.4e-83 273.4 In-house 3-286 (305) alignment
Range on Protein: 41-326
Range on HMM: 3-286/305.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDqatNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.. |......    ...|.. | ..|. ..  .. . ..   . |.||.|||...| .....|..| . . . ..|||||.|. |...  .||. ||||.
iialddlaayikearvysdkgleaqykslyeeeesidvg...kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTK
.| .| ||.|.| | . |||.||.||||||||.||||..|...  . |...| |.||  .. .|.| . . .   .| .| |.|.|.|.|||||||... 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PMLDFVKNVRERIrNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
 .|...|.|...  .|   .|..|||||||||||..||.|   ....  . ||| .|. ..| .| ..|||  || |.|| | ..  .|
sllslikrvqkdq.kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_PTPN12_pd Subfamily PTPN12 57-325 1.2e-81 268.8 In-house 5-279 (290) alignment
Range on Protein: 57-325
Range on HMM: 5-279/290.0
DSEHRLMEEYDDIQAVGSIVRMDQ-----ATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIW
..|... .|. ..... .  ....     |...|.|..|||.  ||||..|||.|   ... . ||||||.| | ... |||| |||||.| .| |||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

EKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYE-HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI
||. .|.||. . || || ||..|||...... ..| ..||.|..|   .  .. ||. ....| .|.| |...|.|||||||...|..|.....|||. 
eknveivvmaCrevelgkkkCerYWpeegeeelefg.efevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelq

RNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
...   .|..|||||||||||| ||.|   . ....     .||  .| |.| .|. ||||. || ... ........
ese..daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

0040439 (Phosphotyrosine protein) phosphatases II 83-323 3.2e-80 264.6 In-house 7-246 (249) alignment
Range on Protein: 83-323
Range on HMM: 7-246/249.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. ..|| |||.  ||||.||||||  |.|   .|||||.||.|....|..||.|||||||..| |||.|| ..|.|||.|..|| |. ||.||||   | 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

SDTYgGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN---KcviKPVIVHCSAGVGRTGTYIALD
| .| | . | | |.  ......||..|.  ... .|.| ..|.|.|||||||. ....|||.. ||. ...   .   .||.||||||||||||.||..
sley.gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkg...gpvlVHCsaGvgRtGtfiaay

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
 . ...| .  ||.  .|...|..|.. ||.. ||.|....|....
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0045098 (Phosphotyrosine protein) phosphatases II 83-323 5.5e-80 264.0 In-house 29-272 (278) alignment
Range on Protein: 83-323
Range on HMM: 29-272/278.0
NAEVNKTKNRFNKILPYEHSRVKlmalkgksetDYINANYIPGFnsPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. . |. |||.  ||||.|||||          |||||.||.|.  |...||.|||||.|..| |||.|| ..|.|||.|. ||.|. ||.||||   | 
lylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..gg

SDTYgGSLEVSLQSELDYEHWITRTFMLQ------KNKMKREVIQLQFTSWPDHGVPEQT--KPMLDFVKNVRERIR--------------NKcviKPVI
| || | ..| |.||  ......||....      .. ..|.| .|....|||||||...  |..|.... .||...              ..   .||.
slty.gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg...gpvl

VHCSAGVGRTGTYIALDRLTQHMedNDFVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLMDYF
||||||||||||..|.. . ...  .. ||.  .|.|.|..|..  ||.. ||.|....|....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

0042113 (Phosphotyrosine protein) phosphatases II 83-323 2.6e-79 261.4 In-house 5-243 (245) alignment
Range on Protein: 83-323
Range on HMM: 5-243/245.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkGR
. ..||.|||.  ||||.|.||||.  .|   .|||||.|..|.. .. .||.|||||||..| |||.|| ..|.|||.|...| |. ||.||||   | 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

SDTYGGsLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIR--NKcviKPVIVHCSAGVGRTGTYIALDR
| |||. . | | ||  ......||....  ... .||||......|||||||. .. .|||.. ||. ..  ..   .||.||||||||||||.||...
sltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsn...gpvlVHCsaGvgRtGtfiaayl

LTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. ...| .  |..  .| |.|..|   |||. ||.|....|....
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPN6_pd Subfamily PTPN6 60-322 2.9e-79 261.2 In-house 26-296 (306) alignment
Range on Protein: 60-322
Range on HMM: 26-296/306.0
HRLMEEYDDIQAVGSIVRMDQA-TNAEVNKTKNRFNKILPYEHSRVKLMaLKGKSETDYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKST
  ..||....|   .  ....  ..   ||.|||.. |||..|.||.|   .. ...||||||||     .| ..||| || |..| .| |||.|...|.
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

IIVMMTKTVEGGKDKCHQYWPKKKGRSDtYgGSLEVSLQSELDYEHWITRTFMLQ---KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNK
.|||.|| || ||.|| .|||... ... | |...|.  || . ...| |.....   |.| .|||.|..|.||||||||.... .|||...|... .. 
vivmttkevErgkekCarYWPdeeekee.y.GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

C--VIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
      |..||||||.|||||.| .| |.. .| . .   .|.  .|  .| .|. |||||.|| |..  .  |
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_Ptp69D_pd Subfamily Ptp69D 42-324 3e-79 261.3 In-house 4-287 (307) alignment
Range on Protein: 42-324
Range on HMM: 4-287/307.0
VLLANIETHYDWLKADSEHRLMEEYDDIQAVgSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPE
. . ..|. .   | |... |..||. ..|   | .  .... . |. |||...| .... ||||  ..|| ..|||||..| |..  ...|| |.|. .
iaiddleealksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK-------MKREVIQLQFTSWPDHGVPE
| .| ||||.|...|.|||...  |  ..||..|||.       || .. | | ||   ...| |.. . |.|        .|.|.| ..|.|.|  |||
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

QTKPMLDFVKNVRERIRNKcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
... .|.....|||  ...    |..|||||||||.|...||| | |... .| ||.. .|...| .|| |||   ||.|..  |.||  
vargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPN9_pd Subfamily PTPN9 47-323 4.3e-79 260.6 In-house 3-290 (297) alignment
Range on Protein: 47-323
Range on HMM: 3-290/297.0
IETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDqATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
||   ...|.  .. |..|| .|..     ... |..  .| .|||.. .| |...||.|  .......||||||.. |.. .. .|| ||||..|..| 
ieelvayvkekgkrGlskeyaeirnepveGtfl.asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||.||..  .|||.|..|| |. || ||||.... |. .| .|.||  .   .|.. .|.. ..  |.. .|.|.  ||.||||.|||.... .||...
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg.dlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

NVRER-----------IRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.|||.            . ..   |..||||||.|||||.|.||   ...|. . |||. .|  .|  | . .||. || | . ....| 
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_PTPN3_pd Subfamily PTPN3 64-322 1.3e-77 255.5 In-house 19-274 (280) alignment
Range on Protein: 64-322
Range on HMM: 19-274/280.0
EEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYI----PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
 ... .      . ...|  .| | .|||.  ||||.. ||||     .||||||||||.    |. .    |||.||||..|..|.|.|.||.||..||
aqfeqlyrkkpglaisaarkpe.nlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MMTKTVEGGKDKCHQYWPKKKGrSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRnKCVIK
|.| .|| |. |||||||...  . .|| ...| ...|   . ...| ..|....   .|...|||...|||||||.... .|.||..||.  | .   .
mlttlverGrvkChqyWPeted.eleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.r.sgkee

PVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
||.||||||.|||| .|.|.   . .| .. | .  .| .||  |  ||||..|| |. ....  
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 40-326 2.7e-77 254.8 In-house 4-282 (315) alignment
Range on Protein: 40-326
Range on HMM: 4-282/315.0
RPVLLANIETHYDWLKADSEHRLMEEYDDIQAvGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPL
.|. | .. |.    || ..  . ..|. |   | .  .| | . | || |||. .|..|..|||.|  |. ....||.|||.|.|.| .| |||.|||.
qpipldqlityvaqkkastkngfkqdyesipg.gqlhpldvakkie.nkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

PETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgrSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPM
... .|.||...|.. . |||.|..||| | |. .||| |     .| | . |...||  ....  ||.    ..  |||.||..||||| |||. | |.
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviy.Gkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytipl

LDFVKNVRERIRNKCviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSG
......|.    |.    ...||||||||||||.|.|| . ...| .. .||  ..  .|  |  .||.  || ||.| |.. |  |
mnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 62-323 4.6e-76 251.0 In-house 20-276 (515) alignment
Range on Protein: 62-323
Range on HMM: 20-276/515.0
LMEEYDDIQavGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
. ||. |.   |  .  .  .. |.| .|||.. ||||. .||||  .. . . ||.|| |||.|.. . ||| |||.. ...|.||...... | |.|.
fseefhdlp..gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRNKCViKPVIV
||  || | || .|||.| | |  .| |..|.| |       | |.. . |..  | | | .|| |||.|||..|. .| ..|.|.   ...    |.|.
tklkegdkikcgkyWPdkpgdsvkfG.sikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkad.hgqyt.hplii

HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|||||||||| .|..|    |... . |||  .|  .| .| |||||. || ||.. .....
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 82-323 7.1e-76 249.9 In-house 23-268 (274) alignment
Range on Protein: 82-323
Range on HMM: 23-268/274.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSE-TDYINANYIPGFNS-PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
..   ..||||...||| |.||| | . ....| ..||||||| |..   . |.| |||||.| .|.||||.......|||.||  |  ..||..|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

KGR--SDTYGGsLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRER-IRNKCVIKPVIVHCSAGVGRTGTYIAL
..   |..||. .|.  .. .. ...  |...|.. . .|.|.   .|.|||| .|......||.|..|.|   ...  . ||.||||||.|||| .|| 
edyeiserygd.veikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.   ...... .||| ..||..|..|  .|||. || .||  |. | 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 57-322 1.5e-75 249.4 In-house 31-290 (319) alignment
Range on Protein: 57-322
Range on HMM: 31-290/319.0
DSEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKST
|   .|  |.  .  .|      . .| . || |||. .||......|||  | |.  .||||| .. |. ..  |||.||||..| .|.|||||| ...
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

IIVMMTktveggKDKCHQYWPKKKgrsDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNK
 ||..|      |||| ||||.|    .   .  .|...|  . . .. | . | .   .| .|.. |  |  |||.|||... ... .||.||   . .
tivllt......kdkcsqywplki...vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

CVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
   ....|||||||||||.||.|| | . |.... |||  .| ..|  || |||  .|| ||.  |.. 
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_PTPN13_pd Subfamily PTPN13 63-320 2.3e-75 248.4 In-house 14-266 (273) alignment
Range on Protein: 63-320
Range on HMM: 14-266/273.0
MEEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLMALKGksetdYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVM
 ||..... . .. . ... ..| ||.|||. ..|||...|||| .  |     ||||..|     .   ||||||||||||..|.|.|.||.|...|.|
aeefkelrelkpldtcevgkkke.nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

MTKTVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKM--KREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRnkcVIKP
.|. .|.|| |||.|||..|... .  . |||.|    ... .  |........    ||| .|.|..||||||| .....| ||..||.  .      |
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagP

VIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..||||||.||.||.|..| . . .| .  .||  .| ..|  |. .|||. ||||..  ..
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 84-323 4.1e-75 247.2 In-house 6-242 (250) alignment
Range on Protein: 84-323
Range on HMM: 6-242/250.0
AEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDkCHQYWPKKKgrS
   || |||. .|.....||| |   ||  |.||||| .. |..  . .|| ||||..|..|.|||..|.||. |||.|. .| .|  .||||| .|  .
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..a

DTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKRE--VIQLQFTSWPDHGVPEQTKPMLDFVKNVReRIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ
..|| .. ||| |.  .  ...|...| |.| . |  | ||.|..||| ||||... .|...|.|. . ....  .||||.|||||||.|..||.| . .
ekyG.dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq.asqqqagnaPvivqCsaGvgrsGafiaidavle

HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
... .  |||  |.  .| .|   |....||.|..  .. . 
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal

0037934 (Phosphotyrosine protein) phosphatases II 83-323 2.6e-74 245.1 In-house 6-242 (243) alignment
Range on Protein: 83-323
Range on HMM: 6-242/243.0
NAEVNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIPGFnsPReYIACQGPLPETTND----MWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPk
. ..|..|||.  ||||.||||||      . .||||||.|...  || .||.|||||||..|     |||.|| ..|.|||.|..|| |. ||.|||| 
llpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

kkgrSDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN---------KcviKPVIVHCSAG
    .... | ..| | ||  ..... ||..|.    .. .|.||......|||||||. ....|||.. ||| |..         .   .||.||||||
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg...gpvlVHCsaG

VGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLMDYF
||||||.||.. . ...   . ||.  .|...|..|..  |||. ||.|....|. ..
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 80-322 5.8e-74 244.1 In-house 18-254 (284) alignment
Range on Protein: 80-322
Range on HMM: 18-254/284.0
QATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTktveggKDKCHQYWPKK
. .| . || |||. .||......|||  | |.  .||||| .| |. ..  |||.||||..| .|.|||||| ... ||..|      |||| ||||.|
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

KgrsDTYGGSLEVSLQSELDYEHWITRTFMLQK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIAL
    .   .  .|...|  . | .. | . | .   .| .|.. |  |  |||.|||... ... .||.||   . .   ....|||||||||||.||.|
i...vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
| | . |.... |||  .| ..|  || |||  .|| ||.  |.. 
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_PTPRK_pd Subfamily PTPRK 50-324 2.8e-73 241.5 In-house 12-279 (314) alignment
Range on Protein: 50-324
Range on HMM: 12-279/314.0
HYDWLKADSEHRLMEEYDDIQAVgsivrMDQaTNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRM
.   ||.   . . |||. .         |  .. . |..|||...||.|..|||.|....| ...|||||..| ... |...|. ||||.||..|.||.
siallkraegygfkeeyeslfeg.....wda.akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

IWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkgrSDTYGgSLEVSLQSELDYEHWITRTFMLQK----NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKN
....... |||.|. || |. || .|||..   ...||  ..| | .    .  ..|.| ..|     . .||| |.||..||||.|| . . .|..|..
vydencasivmltelvevgrvkClkyWPed...tevyg.dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr

VRERIRNkcVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD-YFC
| .   .     ...|||||| |||||.||.| . . .| .. |||  .| ..| ..  .|.|| ||.||.| ...  .|
vkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 78-323 8.7e-73 239.9 In-house 35-277 (315) alignment
Range on Protein: 78-323
Range on HMM: 35-277/315.0
MDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWP
  ...  ..| .|||.. |||....||||  .  . . ||||| ||..... . ||| ||||. . .|.|||....| | |||.||  || | || ||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

KKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALD
..|. |  .| |..|.| |       ..| ....| . .| | | ||| |||.||..||  .| ..|.|.    |.    ...|||||||||||  |..|
drkadsvefG.sikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisid

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
   ....... |||  .| ..| .| |||||| .| ||.| .....
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 83-322 3.5e-70 231.1 In-house 16-263 (270) alignment
Range on Protein: 83-322
Range on HMM: 16-263/270.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKG
.|  .|. ||.. |||  ..||.|  |. .|.| ||||||..||. ....||| .|||| |... ||||||.|.| |||.|. .| |..|| .|||....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

R-SDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTK------PMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYI
.  ..  | ..|  .||   | .|..   |...  .|...  ....|||||||...        .|  ...||.  ...   .|..|||||||||||| |
ekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

ALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|||  .. .| .  |||  .. |.| .|  |||.  || |..  .. |
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 44-327 1.2e-69 230.0 In-house 7-292 (325) alignment
Range on Protein: 44-327
Range on HMM: 7-292/325.0
LANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETT
. |.  | .  ||. .  .  |.. . ....| .  ...    || ||||. ......||| | ..| ....|||||.|.  .     ..|.| ||..|.
vvnlvehvekkkaqdqdgfahefgllpsddgiak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

NDMWRMIWEKKSTiIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGsLEVSLQSELDYEHWITRTFMLQKNKMK--REVIQLQFTSWPDHGVPEQT---KP
||.||.. . ... .|...  ...|||.| .||||. | | |.|| |||.|..  ..  .. | . ... |    | | |.|. ||.| ||...     .
ndlWrlvldWrcs.vvvvlneldlgkdrcavywpkemgksktfGg.levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis

MLDFVKNVRERIRN-KCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCSGV
.|. ||.| ||..       |..|||||||||||..|.|  . ... ..  ||. |.|  .| .|  .|.|  |||.|...|.... || 
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn

subfamily_PTPN14_pd Subfamily PTPN14 59-323 7.2e-67 220.5 In-house 22-296 (300) alignment
Range on Protein: 59-323
Range on HMM: 22-296/300.0
EHRLMEEYDDIQAVGSIVRMdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKsETDYINANYIPGF--NSPREYIACQGPLPETTNDMWRMIWEKKST
| ..  ||. |.       . .... ..|. ||||...||||..||.|.. | . .|.||||  |      . |.||..||||. | .|.|.|.||.. .
egkvfteyeripkkredall.staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

IIVMMTKTVEGGKDKCHQYWPKKKGR--SDTYgGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNV---RER
.|||.|.. |.||.|...|.||.. .  . .. |  .|. .   | .  ||... |.    | .|.|. ||.| ||||||||  |..|.....|   |..
livmlteeeedgkeksfkyfPkleskkktvef.gkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

IRNKC----VIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
  ..     .  ||.|||||||||||  |  | |.. .| |. .|.  |.  .|  | .|||| .|| |... |. |.
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 71-325 7.3e-67 220.6 In-house 35-286 (297) alignment
Range on Protein: 71-325
Range on HMM: 35-286/297.0
AVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKd
   . .. .  ..  ||  |.|.. ||||. |||||  .  . . ||.|| ...|..   ..|. | | ..| .|.|.|..... ..|||...  |. | 
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.

KCHQYWPKKKGRSdtyGGSLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPE--QTKPMLDFVKNVRERIRNKCVIkPVIVHCSAG
|| .||..|   .    |.. | |.|  . |  | |.. ..|.|  ..| | | ||..|||. |..  ... .|.....||.   ..    |..|||.||
kcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaG

VGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
||||| ....|    ...... ||. |.|  .| .| |||||. || |..  ..... |
vGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 79-324 6.1e-66 217.2 In-house 38-284 (290) alignment
Range on Protein: 79-324
Range on HMM: 38-284/290.0
DQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSE--TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYW
 .  ... ||..|||..|..|.  |. |  . |. .   .|||| || |..  ..||| |||...|  | |..||..|.|||||.|. .| ||.||.|||
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PKKkgRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKM---KREVIQLQFTSWPDHG-VPEQtKPMLDFVKNvRERIRNKCVIKPVIVHCSAGVGRTGT
|..   ...| |  .. |..|  ... |.|.. .....    |..|.|.|.|.|...| |... . .|  ... ..... |   ....||||..|||...
pds..dtkay.gefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp.qtillviee.myktqrkrgntsivvHCSdtvgrsav

YIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
..|..   .... .  .||  |. ..|. .  .|||. || .|.. .. |. 
fcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 87-320 9.5e-66 216.4 In-house 3-236 (237) alignment
Range on Protein: 87-320
Range on HMM: 3-236/237.0
NKTKNRFNKILPYEHSRVKLMALKgkSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKgRSDT
|| |||. .|  |.|||| |      |..|||||.|. ||. .|..|||.||||  . .|.|.|.|..| ..|||.|  .|| . |||.|||. . .  .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa

YGgSLEVSLQSELDYEHWITRTFMLQKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQH
||  | |||. . ..  .  |...|.|.  ..||    | |||||||.|||.||  .| | ||. .| .      | |.|||||||||| .. .| . ..
yg.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
 ...  ||.   |  .   | |..||. ||.|||. ..
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_PTPN23_pd Subfamily PTPN23 57-320 1.5e-65 215.9 In-house 18-277 (288) alignment
Range on Protein: 57-320
Range on HMM: 18-277/288.0
DSEHRLMEEYDDIQavgsiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKS
| .....|...| .      |    . |... .|||.. ||||.|.||||     .|. ||||| .. .  .   ..|| |.||..| || |.|..|.||
dkkfkeleqkqdke.....arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

TIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGsLEVSLQSELDYEHWITRTFMLQKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE---RI
 .|||...  | || |...|||..||.. ..|  |.|.|.|. . |... |.. |. ..   ...|  ||.||||..|||.  . .|.|...|..     
sviVmllskeelgkpkvdrYwPedkgetvkfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

RNKCVIkPVIVHCSAGVGRTGTYIALDRLTQH-MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..|. . |..|||||||||||..  .    .   ..|  .|.  ||  .|  | . ||...|. |  .  .
qrkskt.PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 83-325 5.6e-62 204.3 In-house 43-280 (287) alignment
Range on Protein: 83-325
Range on HMM: 43-280/287.0
NAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGr
 |. || |||...||...  || |     . . ||||| .| |... ...|....|. .|  ..|..|.... |.|||...  |  ...|.||||..|  
iasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

sdTYGGSLEVSLQSELDYEHWITRTFMLQKN---KMKREVIQLQFTSWPDHG-VPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDR
  .. |  ...| .|  ....| |.. ....   . |..| | |.|.|...| |.|.   .| . . ....   |    ...||||..|||.....| . 
..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq..rkrgntsivvhCsdtvGrsamfcaaat

LTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
  .. . .  .||  |. ..|. .   ||| .||.|| | .. |  |
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_PTPN1_pd Subfamily PTPN1 64-316 9.9e-61 200.0 In-house 10-264 (290) alignment
Range on Protein: 64-316
Range on HMM: 10-264/290.0
EEYDDIQAVGSIVRMDQAtNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
| | ||.   | ... .| . . |...||.  . ||.|||.||     ....|||||. .   .  |.||  |||||.|.. .|.|.||.||  .||. |
eiyldirkeasdfptrea.klpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

TVEGGKDKCHQYWPKKKGRSDTYG--GSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPV
 || .. ||.||||...  .       .|.| | || ...... |.. |..   .  ||...  .|.||| ||||    .|.|. .|||    .    |.
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

IVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIH
..|||||.||.||.. .| .  ..|..|    ||.  |..|.| .|  |.||  |  | .
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 74-323 1.4e-60 199.5 In-house 26-277 (287) alignment
Range on Protein: 74-323
Range on HMM: 26-277/287.0
SIVRMDQATNaEVNKTKNRFNKILPYEHSRVkLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCH
| . . .|..   .  |||. ..||....|| |.. .|.  .|||||||.....   ..||.|||.. | .|.||...|..|. ...||. || .. ||.
statfkaaee.laavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPKKkGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKR--EVIQLQFTSWPDHGVPEQTKPMLDFVKNV---RERIRNKCVIKPVIVHCSAGVG
.|||..  .    ||   | |. .    .. .|.. | . . .    | ||.. ||||....  .  .. || .|    |  |.   . |..||...|.|
kywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|.|...|.  | . .||   |||  ||  .|..|. |||.  |. .. . |. |.
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 48-322 4.4e-58 191.8 In-house 8-278 (439) alignment
Range on Protein: 48-322
Range on HMM: 8-278/439.0
ETHYDWLKADSEHRLMEEYDDIQAVGSIVRMDQATNA-EVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
. | . |. . .  . |... |...    . . .  | | ..||||.... ...|.|| |  . |   . ||||||| |.  .. |||.|||  |||.|.
qehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WRMIWEKKSTIIVMMTKTVEGGKdkchqYWPKKkgrSDTYGGSLEVSLQSELDYEHWITRTFMLQ----KNKMKREVIQLQFTSWPDHGVPEQTKPMLDF
||...|||.. |||.|. ||  |     ||| .   .... | . |  . ...  ... | | .     ... .| |.|.....|||. || |.  .|||
wrlviekktvtivmltnlvesyk.....ywpsd...aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

VKNVRErIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
.. .     .|  . ||.|||||||||||| ||||   ...  .. ||. |.|  .| .|. .||.  ||.||...... 
lrains.andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled

subfamily_CG7180_pd Subfamily CG7180 85-325 1.3e-57 189.7 In-house 40-292 (296) alignment
Range on Protein: 85-325
Range on HMM: 40-292/296.0
EVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKdKCHQYWPKKKgrSD
. |. |||  |..||.. || |  |.|....||||| |. .|  ..|||  ..|  || .. ||.......  .|..||| .  | ....|||.|     
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..ke

TYGgSLEVSLQSELDYEHWITRTFMLQKN------K------MKREVIQLQFTSWPD-HGVPEQTKPMLDFVKNVRER---IRNKCVIKPVIVHCSAGVG
 ||  ..| . .|  | .  .||| |.|.      .       .| | ..|.| |.  . ||  |. ...... ||     . .. . .||.|..| |..
qyg.eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
|.| |.|.|   . .| .. ||| . |  .| .|. ||.. ..| .| | | ...  
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc

subfamily_PTPRN_pd Subfamily PTPRN 58-320 2.2e-57 189.0 In-house 27-289 (297) alignment
Range on Protein: 58-320
Range on HMM: 27-289/297.0
SEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPRE--YIACQGPLPETTNDMWRMIWEKKS
 ..|| .|.. . |  .  .  ....|| | .||| ...|||.|||||| .   ....|||||  |   . ||.  |||.||||..|  |.|.|.||. .
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGv

TIIVMMTKTVEGGKDKCHQYWPKKkGrSDTYGgSLEVSLQSEL-DYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRN
..||..|.  | |  .|..|||.. | |..|.   || | ||    . .. |.| |.  ...  | | |. | |||..||| ..|..|.| . |    | 
vvivnltrleeegvkqckrywpde.G.sevyh.iyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG

KCVikPVIVHCSAGVGRTGTYIALDRLTQHMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
..   |..||||.|.||||.||..| . ...      .|..  .  .|  |. ||.|. |. |.  .. 
rsc..pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 62-320 7.8e-57 187.4 In-house 22-233 (392) alignment
Range on Protein: 62-320
Range on HMM: 22-233/392.0
LMEEYDDIQavGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
..||. |.   |  .  ..... |.|. |||...||||. .||||  .   ...||.|| |||.|.. . |||.||| . . .|.|||..... | |.|.
ffeefhdlp..gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TKTVEGGkdkchqywpkkkgrsdtyggslevslqseldyehwitrtfmlqKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnKCVIKPVIV
||  ||                                            | . .| | | .|| |||..||..|  .| |.|.|.         .|.|.
tklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf..Gqythplii

HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLM
||||||||||  |..| .  | .   .|||  .| ..| .| |.|||. || ||. ...
hcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 81-319 1e-56 186.8 In-house 2-237 (239) alignment
Range on Protein: 81-319
Range on HMM: 2-237/239.0
ATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
|..  |||.|||. .|. |.|||| |  |     .|||||.|.  .. ||. ||| || .  .. |.|||.|...  .|||.|  .|| | |||||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

KGRsdtYgGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALD
  .   |   | |.|.    .  .| |||.. .     .| | | .|| |||.|||. .  .| . ... .   .    .| ..||||||||||... .|
tsk...y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvid

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
 . .. . .  ||.   |  .|  | ..|||  ||.||| ..
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 83-319 1.4e-56 186.3 In-house 3-236 (239) alignment
Range on Protein: 83-319
Range on HMM: 3-236/239.0
NAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKG
.  |||.|||. .|. |.|||| |  |     .|||||.|.  .. ||. ||| || .  .. |.|||.|...  .|||.|  .|| | |||||||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

RsdtYgGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERirNKCVIKPVIVHCSAGVGRTGTYIALDRL
.   |   | |.|.    .  .| |||.. .     .| | | .|| |||.|||. .  .| . ... .   .    .| ..||||||||||... .| .
k...y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidam

TQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
 .. . .  ||.   |  .|  | ..|||  ||.||| ..
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 75-321 1.2e-53 176.8 In-house 21-264 (283) alignment
Range on Protein: 75-321
Range on HMM: 21-264/283.0
IVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGksetDYINANYIP---GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDK
  .  . . |. ||.|||...|.|..  ||.| ..      ||||| .||     .  ..||..|.|| .|  |.|.|....| | |||.||  |. . |
pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

CHQYWPKKkGrSDTYgGSLEVSLQSELDYEHWITRTFMLQKN---KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREriRNKCVIKPVIVHCSAGVG
| |||||. | |  | | . |.|. |   . .| . ..|..|   | .  .   |.  | . |       .. | | .    ...    |..||||.|.|
CsqyWPkr.G.sedy.GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvisl..qteskkgPivvhCstgiG

RTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
||...||.    ...  .  |||  ||  || .|  .|||  || ..|.  ..
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

0051429 (Phosphotyrosine protein) phosphatases II 115-325 4.1e-53 176.1 In-house 4-227 (272) alignment
Range on Protein: 115-325
Range on HMM: 4-227/272.0
TDYINANYIPGFNS---PREYIACQGPLPETTNDMWRMiWEKKSTIIVMMTKTVEGGKDKCHQYWP---------KKKGRSDTYGGSLEVSLQSELDYEH
..||||....|...   |. .....|||| | .| ||. .| . . ||......| |..||..|||            .  .   | | | |.||  ...
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

WITRTFMLQ---KNKMKREVIQLQFTSWPDHGVPEQTkpMLDFVKNVRErirnkcvIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVD--------V
.| |...|    .... ||| .|..|.|||||||...  .|.... ...        .||.||||||..||||..||..| . ..... ||        .
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

CGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
 ..| |.| .| . ||||.||.|....|.....|
eeaveelraqrpgavqteeqylflyeallellrs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 61-323 1.7e-52 173.0 In-house 16-293 (301) alignment
Range on Protein: 61-323
Range on HMM: 16-293/301.0
RLMEEYDDIQAVGSivRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKG--KSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTII
.. |.|.... . .  .  . .  | ||. |||..| .|.. |. |   .   .....||||.|| |... ...|| |||. .|  |.||.||..| . |
kfeeqykelkeged..ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMMTKTVEGGKDKCHQYWPKKKGRSDTYgGSLEVSLQSELDYE-----------------HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLD
||.|.. || |.||.||||. . .|... | ..| |..|  |                    | |.|  ...|  ..|.||| |.||..||  . . .| 
vmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

FVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
 . .|  | ..|    ||.||||..|.|.|.|....        .  ||| .|.  .|  .   |.|  ||..|.| .  |.
viddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

0041856 (Phosphotyrosine protein) phosphatases II 87-324 5.3e-52 171.4 In-house 1-172 (182) alignment
Range on Protein: 87-324
Range on HMM: 1-172/182.0
NKTKNRFNKILPYEHSRvklmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTktveggkdkCHQYWPkkkgrsdty
|..|||. .||||.|||            ||||||.. |   ....||.||||..|..|..||..| . |.||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ggslevslqseldyehwitrtfmlqkNKMKREVIQLQFTSWPDHGVPEqTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIALDRLTQHmedn
                          .. .|..||.....|||||||. .  .|||.. |.|        .||.||||||||||||..|.. . ..    
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

dFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
  |..  .|...|..|.  |.|. ||.|....|.... 
.gvsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 82-324 2.3e-49 163.0 In-house 35-278 (307) alignment
Range on Protein: 82-324
Range on HMM: 35-278/307.0
TN-AEVNKTKNRFNKILPYEHSRVkLMALKGKSeTDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKK
..  . |  |||.. .   ...|. .. ..| . .||| |||.     |. .|..|||| .|  ..| |. ..|   ..|. |..| .| ||.|||| ..
veafsantdknryqdvkcqdkgri.vvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

GRSDTYGGSLEVSLQSEL------DYEHWIT-RTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnkcviKPVIVHCSAGVGRTGTY
|.  ..| . .    ..|        |. |   |. ..  .  | . .||.. |||.|||.     ..... ||          ||.|||||||||.|| 
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt......npvvvhcsaGvGrsGti

IALDRLTQHM-EDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
.|.  . . | .  .  |.  .| |.| .|.| .||| ||...|  |..|| 
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl

0036282 (Phosphotyrosine protein) phosphatases II 115-317 9.5e-49 160.7 In-house 2-164 (174) alignment
Range on Protein: 115-317
Range on HMM: 2-164/174.0
TDYINANYIPGFNSPREYIACQGPLPettndMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkkgrsdtyggslevslqseldyehwitrtfmlQKNK
.|||||... ..  ....||.||||.      |.|..| ..|..||... .| |. ||..|||                                  .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

MKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVRERIRNkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEdNDFVDVCGVVCEMRMHRNYLVQTETQYIF
..|..||.... |||||||. .. .|.||| |.| . . .  .||.|||||||||||| .|.... .... ...||.. .| |.|..| . |||. ||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IHD
...
lyy

subfamily_ptpA1_pd Subfamily ptpA1 60-275 2.9e-46 153.0 In-house 27-248 (418) alignment
Range on Protein: 60-275
Range on HMM: 27-248/418.0
HRLMEEyddiqAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
 ||.||     .||         . . | .|||. .||| .|.||.|  .. |  .|||||||| |   |...|. |||||.|  |.|||.||..  |||
frllee.....svgpset..segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriiv

MMTKTVEGGKDKCHQYWPKKKGRS--DTYGGSLEVS------LQSE-LDYE-HWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRER
|...  |  . || .|||.. |      ||   ||       |     | |   |||   |  .   |.. | |.  |||| .|..|.|. ...... .|
mlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

I----RNKCVIKPVIVHCSAGVGRTGTYIA
      .     |.|||||||||||||. .
qnqiipssdrnvpiivhcsagvgrtgtfct

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 84-322 5.7e-46 151.5 In-house 53-282 (290) alignment
Range on Protein: 84-322
Range on HMM: 53-282/290.0
AEVNKTKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPreYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRS
.. . .|||.  .   . .||    ||   . ||. |||. | ...  .|  ||.| .|. |.|||. ..| . |||. . .| || ||.||.|.|.|. 
kntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

DTYGGSLEVSLQSELDYEHWITRTFMLQKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIALDRLTQ
 |.|    .  ... . .. | .|. ...     .  .  |.  ||||. |.  |  .|  .. .|.      .  ||.||||||.|||||..|..   |
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglq

HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
 . |   .|. ..|  .|  |   || ..||. . . |.|.
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 57-324 6e-46 151.5 In-house 27-290 (305) alignment
Range on Protein: 57-324
Range on HMM: 27-290/305.0
DSEHRLMEEYDDIQAVGSIVRMDQAtnAEVNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKS
  | | .  |   .    ..  .|.  |....||||.. .   ..| |||   .  | .||| |||.     | . .|..|||| .| ...| |. ..| 
reefrglakytrpdmtqvafnanqs..adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

TIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGGSLE---VSLQS--ELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREri
  |||. |||| || || ||||  .|   .  . .    ||     | | |  ||   .    . |  | .||.| ||| |||      |...  .|   
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg..

rnKCVikPVIVHCSAGVGRTGTYIALDRLTQHMEDND-FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
    |  |..||||||.||||| .|.. . ... .|     .  .|  .| .| . .|.. ||.|||  ...|| 
..skv..pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

0043147 (Phosphotyrosine protein) phosphatases II 113-316 5.9e-45 148.4 In-house 3-154 (172) alignment
Range on Protein: 113-316
Range on HMM: 3-154/172.0
SETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTveggkdkchqywpkkkgrsdtyggslevslqseldyehwitrtfMLQK
. .|||||.|...   |...||.||||..|..| |||..|.. |.||..|.                                             .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

NKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVRE--RIRNKcviKPVIVHCSAGVGRTGTYIALDRLTQHMedndfvDVCGVVCEMRMHRNYLVQTET
 . .|..||.....|||||||  .. .|.|.. ..|   ....   .||.|||||||||||| .|.. . ...      ..  .|...|..|.. ||.. 
ellerlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnps

QYIFIH
||.|..
qyrfly

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 57-322 2e-43 143.3 In-house 3-258 (267) alignment
Range on Protein: 57-322
Range on HMM: 3-258/267.0
DSEHRLMEEYDDIQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKST
|.|  . .|.. |. . ..        || |. .||... |||...|| |     ..| .|||| |. |..  . .|. |.||  |  | . .| ..| .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

IIVMMTKTvegGKDKCHQYWPKKKGRSDTYGG-SLEVSLQSELDYEHWITRTFMlQKNKMKREVIQLQFTSWpdhGVPEQTKPMLDFVKNVRERIRNKCV
.||..||.   ..|. ...|| | |..  |   ..| ||. | .  . ||  .   ||.  ..|    .  |    .  . || |  .  .  . . .  
vivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw...nintnnkpylkplfgilaknqleng

IKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
 .|..|.||.||||.||.. .|   . .  .. .|.   . ..|  |  ||.|  .||.||. | .|
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0046846 (Phosphotyrosine protein) phosphatases II 115-322 7.1e-43 141.7 In-house 12-172 (176) alignment
Range on Protein: 115-322
Range on HMM: 12-172/176.0
TDYINANYIPGFnsprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDtyggslevslqseldyehwitrtfmlqknk
 ||||||.| |      .||.|||||.|. | ..|..| . |..|..|. || |. ||..|||  .. .                               
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

mkreviQLQFTSWPDHGVPEQtKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDrltqHMEDNDFVDVCGVVCEMRMHRN-YLVQTETQYI
      | ... |||||||.  . .|.... .||.....   .||.||||||.|||||..|..     .| . ...|  .....|..|  . |||. || 
......qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIHDCLMDY
|...... .
flyefelll

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 81-322 6.5e-42 138.1 In-house 31-268 (281) alignment
Range on Protein: 81-322
Range on HMM: 31-268/281.0
ATNAEVNKTKNRFNKILPYEHSRVKLMA-LKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
. |  ||. |||. .|   . |||.|   .  |  |||| ||||      | ||  |||  ||  |.|||||....| |||. . .|  ..|| .|.|..
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

KGRSDTYgGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrnkcviKPVIVHCSAGVGRTGTYIALDRL
      .   | || .     .  .|  . |  .   | . .  .  |||  ||| .. ||  ....| |        | ..||||||||.|| .|..  
ahcclqf.dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars......tppvihcsagvgrsgtlmaveia

TQHMED-NDFVDVCGVVCEMRM-HRNYLVQTETQYIFIHDCLMDY
 | .     . |.  .|  .|.  |   |||  ||..|   |.|.
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

0049772 (Phosphotyrosine protein) phosphatases II 83-322 3.3e-41 137.4 In-house 42-279 (314) alignment
Range on Protein: 83-322
Range on HMM: 42-279/314.0
NAEVNKTKNRFNKILPYEhSRVKLMALKGKSeTDYINANYIPGFnspREYIACQGPLPETTNDM----------WRMI--WEKKSTIIVM----------
. ..|..|||. .|||.. .||.|  | ... .|||||.|. ||   . .||.||||..| .|           |||.  .. .. .|||          
dlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------MTKTVEGGkdkchqywpkkkgrsdtyggslevSLQSELDYEHWItrTFMLQKNKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVRER
            ..  ..|                        .. .. |.|..   . .  ... .|..|..  . .||...|  .. ...|.. ..| 
srLdaAlgKtpllildgng........................neptaadlellk..eelydpelferlgikylripvpDgsap.lledfdeflefieea

irnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRN-----YLVQTETQYIFIHDCLMDY
       .||.|||.||.|||||..... |  ..   . |..  .. ..|. |       ....  ||.||...|..|
....dkggpvlvHCkaGkgRtgtfvvaaylmkll...g.vsleealedvrlkRpinpnpgfieqleqyefilealley

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 64-323 1.1e-40 134.4 In-house 23-271 (288) alignment
Range on Protein: 64-323
Range on HMM: 23-271/288.0
EEYDDIQAVGSIvrmDQATNAEVNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
 || |    .||   | ...   | |..|....   . .||||          ||.|| ..  . .|  | .| ||  | . .|.|. |.    |||...
keyrdspneasi...diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce

TVEGGKDKCHQYWPKKKGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREV--IQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIV
 .| ||.|  .|.| |.|..  .|    |  ..  | .. .. . .  ..... .|   .| .  |.|.||||. .. | ... .      | . ||..|
llekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivv

HCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
|.||||||||| |      . .  .||. .  .. ..| .|   .||| ||...| |.....
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

0049260 (Phosphotyrosine protein) phosphatases II 122-317 1.1e-40 134.1 In-house 1-144 (152) alignment
Range on Protein: 122-317
Range on HMM: 1-144/152.0
YIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWpkkkgrsdtyggslevslqseldyehwitrtfmlqknkmkreviQ
.|.|.. |.|.||.|||.|.|..| |||..| . |.|||.|. .| ||.||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

LQFTSWPDHGVPEQTKPMLDFVKNVRE-RIRNKCvikPVIVHCSAGVGRTGTYIALDRLTqhmednDFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
 ... |||||||. .  .|.... ... ......   ||.||||||||||||..|.. .         |..  .|  .|..|.. |... |..|...
ylhlpwpDhgvpdlsqlllflllfieklaldkgg...pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 82-324 2.5e-40 133.2 In-house 30-271 (285) alignment
Range on Protein: 82-324
Range on HMM: 30-271/285.0
TNAEVNKTKNRFNKILPYEHSRVKLmalKgKSETDYINANYI--PGFNSpREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKK
|  | |   ||.  .   | .|| |   | . . ||| |...  || .    ||. ||||||| .|.|.||...| . ..|.   .||| .||  |.|.|
tayeanpdlnryadvrcieetrvvl...k.nhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

KGRSDTYGgSLEVSLQSE----LDYEHWITRTFMlQKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVRErIRNKcvIKPVIVHCSAGVGRTGT
 |    .|   |..|       .    . . | . . .    |     ..|   |||.  ||...||... | |.. .  |   ||. |||||||||| |
lgevvkfg.kyeitlteckeeaiagtilnaltvi.ntedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpk..ekpicvhcsagvgrtat

YIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
.. .|  | .. .|  ...  .| |||  |   ||.  |..|..  ||.|| 
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 78-243 1e-38 127.9 In-house 22-190 (297) alignment
Range on Protein: 78-243
Range on HMM: 22-190/297.0
MDQATNAEVNKT--KNRFNKILPYEHSRVKLmaLKGKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCH
 .. . |  | .  |||...|| .. .||||  |.. .|.|||||.|.  |  ...  ||  |||| .| .| |....|.   .|||..|  |.|.||| 
gesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

QYWPKKKGRSDTYGGSL-EVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||. ..   . |  . |   .   .... |   . |   . .| |   || |||||||| . . .  | 
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 62-324 1.4e-38 127.4 In-house 24-288 (305) alignment
Range on Protein: 62-324
Range on HMM: 24-288/305.0
LMEEYDDIQAVGSIVRMDQATNAEvNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
| .|.  .. .  . .|    .|. .. |||.  .   .. ||||   .|    .|| |||.     |. .| .| || .|  |.| | ...|   | |.
lraefvamkrfndfekmkafkeaq.eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

TKTVEGGKDKCHQYWPKKKGRSDTY---GGSLEVSLQSEL------DYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERi
 . .| |  ||..|.. |..   ..   |  . | ..|        | .  .|.| ..     . .| | .  .  ||| |||     .|..... |   
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.

rnKcviKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFV-DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFC
  |    |..||||||.||||. . |. . . .   . . |   ..  .|  ||  .||..||.|.|. ...|| 
..k...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

0044763 (Phosphotyrosine protein) phosphatases II 98-320 1.5e-37 124.3 In-house 1-168 (178) alignment
Range on Protein: 98-320
Range on HMM: 1-168/178.0
PYEHSRVKLMALKGKSETDYINANYIPGFnsprEYIACQGPlpettNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGrsdtyggslevslqse
|....||.|. | |   .|||||..| ..     |.....|      | .....| . | ||..|...|.|. ||..|||.. |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

ldyehwitrtfmlqknkmkrevIQLQFTSWPDHGVPEQTKPMLDFVKNVRERI-RNKcviKPVIVHCSAGVGRTGTYIALDRLTQHmedndFVDVCGVVC
                      || ... .||||||. .. .|.||. ..| . ...   .||.|||||||||.|| .|.. . ..      ...  .. 
......................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

EMRMHRNyLVQTETQYIFIHDCLM
..|..|.  |... |. ..... .
lvrerRp.ivpnpgqlrqLyefel

0051082 (Phosphotyrosine protein) phosphatases II 115-319 1.2e-36 120.9 In-house 3-149 (151) alignment
Range on Protein: 115-319
Range on HMM: 3-149/151.0
TDYINANYIPGFnspreYIACQGPLPettnDMWRMIWEKKSTIIVMMTKTVEGGkdKCHQYWPKKKgrsdtyggslevslqseldyehwitrtfmlqknk
.||||..|. |.     .....|||.    | .....| . . ||......| |  .|..|.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

mkREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcV-IKPVIVHCSAGVGRTGTYIALDRLTQHmedndfVDVCGVVCEMRMHRNYLVQTETQYI
  .||.......|||.|.|. .. .|.|.. ...         .||.||||||.||||| .||... ..      |..  .. |.|..| ..||...|..
..ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FIHDCL
|.. .|
fqlfal

PTPc_DSPc_SM00012 219-320 5.7e-35 115.1 In-house 2-104 (105) alignment
Range on Protein: 219-320
Range on HMM: 2-104/105.0
VIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
| ....|.||||||||.....|.....|..  ...   |||.||||||||||||..||| | |..|.. ..||.. .|.|.|..|. .||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLM
.|.
all

subfamily_CG42327_pd Subfamily CG42327 62-251 1.4e-34 114.2 In-house 7-195 (319) alignment
Range on Protein: 62-251
Range on HMM: 7-195/319.0
LMEEYDDIQavGSIVRMDqaTNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVM
..||..|.     | | |        | |.|. ...|  ..|| |     . .. |..|.|. |.. .|  |||.| .| ... |.||..||..| .|| 
vaeefrdlP..qliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

MTKTVEGGKDKCHQYWPKKKGRSDT-YGGSLEVSLQSELDYEHWITRTFMLQK--NKMKREVIQLQFtSWPDHGVPEQTKPMLDFVKNVRERIR
.|.  | | ..| .|.| |..  .|   | . |.|.     ..... |..|..  ... ||.    .  |.. .|| . ....  . .||. ..
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 87-322 3.8e-34 112.6 In-house 52-289 (310) alignment
Range on Protein: 87-322
Range on HMM: 52-289/310.0
NKTKNRFNKILPYEHSRVKLMALKGKSEtDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKkKGRSDTY
.  |||.  ..  . |||||   | . | ||| |||.        .| .||||  |  |.||||.....  |... |..| |. ||  |||   | ..||
ymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtety

GgSLEVSLQSELDYEHWI---TRTFMLQK-------NKM-KREVIQLQFTSWPDHGVPEQTkpmldfVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIA
|  . |.  ||   |  |   . ||. ..        .. .  |  ...  ||| |||..       .. | .|.  .    |..||||||..|... .|
g.cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvrhgpcvvhcsagkdrlyvvva

LDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|.   ....  . ||.  |. |.. .|   .||| ||..|.   . .
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 82-314 7.4e-34 111.8 In-house 45-272 (301) alignment
Range on Protein: 82-314
Range on HMM: 45-272/301.0
TNAEVNKTKNRFNKIlPY-EHSRVKLMAlKGKSEtdYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKK
..| ..| |.|.... |   .. |.... .||     | ||.||    |. .|| ||||..|..|.| |.   .   |||....||  ..||..| | | 
syaylpkdkhryptv.PckPstaveviv.dGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

GRSDTYG-GSLEVSLQSELDYEHWITRTFMLQKNK---MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirnkcVIKPVIVHCSAGVGRTGTYIAL
...   |  ....  .  .  .. . ||. ..        | |.  |...|.|.|||.    . |... |..        ||..||||||.||. ..|. 
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiGrsvafigt

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
. |....| .  ...   . ..| ||   |||..|  .
eylareveadptieltealkhlrehrwngvqtnsqlyw

subfamily_egg_pd Subfamily egg 80-323 9.6e-31 101.6 In-house 34-270 (307) alignment
Range on Protein: 80-323
Range on HMM: 34-270/307.0
QATNaEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGgkDKCHQYWPKK
.| . . |..| | ...   . |||||   .|.   |.| ||.. |     |.| .| || .| .|.|||.....   |||.| ..|   ..|. |||| 
taas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

KGRSDTY-GGSLEVS---LQSELDYEHWITRTFMLQKNkmkREVIQLQFTSWPDHGVPEQTKPMldfvkNVRERIRNkcVIKPVIVHCSAGVGRTGTYIA
.  |  .  |||..    ..|. |    .|.  ..  .   .|   |.   .  . . .   |.     .|  ..||  . |||.|..  || ...| .|
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdvnnssdvyspl.....rvlrklrn..lskpvvvqdilGvskaatlva

LDRLTQHMEDNDF--VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
..    ..         |   |  .|..|.. |..  .|.|..  .. .|
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 64-325 1.2e-29 98.0 In-house 23-278 (312) alignment
Range on Protein: 64-325
Range on HMM: 23-278/312.0
EEYddiQAVGSIVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMalkGkSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTK
 ||   .||| ||   . |     |  ||. .|  ..  |  |    |  |  || ||..     |  ....|||| .|.  .|..     || |.... 
key...kavgnivsdsectaflkfkdlnrypniqcwdrgrftla...g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

TVEGGKDKCHQYWPKKKGRSD--------TYGGSLEVSLQSELDYEHWITRTFMlQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRErirNKcv
 || | .|| .|     |  |         |   .|.  .|     | . .  . .    .  . . |..||||||.|.     | ..  |.    .|  
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvv.katgqesklnhyqwaswpdhgmpdscdtalrllsavkk...dk..

iKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYFCS
 |||| ||||||||||| . .. .   .      .|  .   .|  |   |..  ||..   |..... |
.kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 87-179 5e-27 89.5 In-house 47-153 (350) alignment
Range on Protein: 87-179
Range on HMM: 47-153/350.0
NKTKNRFNKILPYEHSRVKLM-AL-------KGKSETDYINANYIP------GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKC
  .|||.. |||||||||||  .|       .  |  |||||||.         |.   ||| |.|||.| .|....| . | ..|...|. || . .||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HQYWPKK
..||.. 
yrYWqeg

0048076 (Phosphotyrosine protein) phosphatases II 185-322 7.6e-27 89.2 In-house 11-142 (145) alignment
Range on Protein: 185-322
Range on HMM: 11-142/145.0
TYGGSLEVSLQSELDYEHWITR--TFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDRLTQh
 | ||| . |. ||  .. ||.  ...  ..  .|..||.....|||||||. .. .|.|.. ..| ....   .||.||||||||||||..|.. . . 
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll.

medNDfVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
   .. |..  .. ..|..| . |... |..|...... .
...lg.vsleealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 193-317 1e-25 85.5 In-house 23-139 (144) alignment
Range on Protein: 193-317
Range on HMM: 23-139/144.0
SLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIRNKcviKPVIVHCSAGVGRTGTYIALDRLTqhmeDNDfVDVC
 |  .|.  ..|. |    .. ..||.||.....|||||||. .. .|.|.. ..| ....   .||.||||||||||||..|....      .. ... 
ellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtgtlvaaylmk....klg.lsle

GVVCEMRMHRNYLVQTETQYIFIHD
 .. ..|..| . |... |..|...
ealalvrsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 138-319 9.4e-25 81.7 In-house 99-284 (302) alignment
Range on Protein: 138-319
Range on HMM: 99-284/302.0
PLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGG------SLEVSLQSELDYEHWITRTFMLQKN----KMKREVIQLQFTSW
|  .|..  | .| . . .|.| ... ||... || .|. .| |   ..|       |..  |.   | ..    |  .. .    |.|. |  |.|..|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPEQTKPMLDFVKNVrErirnkCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
|||| |..... || .|   |     .  | |.|||||||||||| .|.    |    ..  |.  .|. .|  |   ||.|.| |..  |.
pdhGapkeaytaldilkfc.e.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 129-316 9.7e-24 78.6 In-house 4-197 (199) alignment
Range on Protein: 129-316
Range on HMM: 4-197/199.0
PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK----MKREVIQLQF
 | |||.| || ||  |.|.|.||  |  |||.       .     |||  .  .  || || |. ..      .   ...| .|       ||. . ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPEQTKpMLDFVKNVRERIRNKC--VIKPVIVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
||| ..  |. .  .. ||   ||  ..       ||||||| | | || ..|||   . | |     ||.  |   .|  |  .. .  .| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 130-316 1e-23 78.6 In-house 4-196 (198) alignment
Range on Protein: 130-316
Range on HMM: 4-196/198.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDYEHWITRTFMLQKNK----MKREVIQLQFT
| |||.| || ||  |.|.|.||  |  |||.       .     |||  .  .  || || |. ..      .   ...| .|       ||. . |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPEQTKpMLDFVKNVRERIRNKC--VIKPVIVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
|| ..  |. .  .. ||   ||  ..       ||||||| | | || ..|||   . | |     ||.  |   .|  |  .. .  .| ||.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 215-324 1.1e-21 71.7 In-house 87-195 (440) alignment
Range on Protein: 215-324
Range on HMM: 87-195/440.0
MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERiRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
  | . | .. .|||.|||. . |.| ....| |  ..|.   |..||||||.||||  ||.| . .. . .| .|.  ..  ||  |  .|||  || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHDCLMDYFC
.|..... . 
vheavlegll

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 99-318 3.6e-21 70.6 In-house 30-254 (290) alignment
Range on Protein: 99-318
Range on HMM: 30-254/290.0
YEHSRVKLMALKGKSETDYINANYIPgFNSPREYIACQGPLPET-------TNDMWRMIWEKKSTIIVMMTKTVEGGKD----KCHQYWPKKKGRSDTYG
 |..|| |   . .   ||| ||..  . .  . |. | |. ..        .. | |. . |.. .||. .  |  ..     | .| |.. | . ...
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

GsLEVSLQSELDYEHWITRTFMLQKNKMKR-EVIQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIVHCSAGVGRTGTYIALDRLTQHME-D
| |.|. .|    .  .||. ... .. .   |   .. .| .  |.|.|| .|. ...|      |.   ||||||  |. |  .  |..   | .   
g.ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkv......kasktpvivHcvdGiSrsAalaaiilgyQkiaet

NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDC
.. | .  |. ..| .|. ........ |.   
sgsvkledvlkalrkqralaitsalelafvdag

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 87-178 5e-19 62.8 In-house 48-155 (349) alignment
Range on Protein: 87-178
Range on HMM: 48-155/349.0
NKTKNRFNKILPYEHSRVKLMA-LK-------------GKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKD
  .|||...|||||||||||   ||             .    |||||||.  . ..  . ||| | ||| | .| ...|  ..  ... ...  | . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHQYWPK
||..|| .
kcdiywqe

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 86-321 1.9e-18 61.1 In-house 46-277 (303) alignment
Range on Protein: 86-321
Range on HMM: 46-277/303.0
VNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIpGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDT
 |  ||||  ..  .||.|||      |.. || |.|.  ..| .  |  | ||. |. |.|.|| |.|   ....    |  |   .  .|...   . 
knmdknrfvdvicldhskvkl......sdssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

YGGSLEVSLQSELD-YEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTKP-MLDFVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALD--RLTQ
   |. |    ...  . |  .   . . . |  .   .. .||   .| .. | ..  . ...  .|. .  .| .    .|.||.||.  ..   |. 
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

HMEDNdFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
| |..  .|.  ..  .|  | . ||  .|. ...  | .
hseqa.sldlvkclenvrngrlhavqnlsqfsvvytllae

subfamily_eak_pd Subfamily eak 49-244 2e-17 57.6 In-house 18-205 (332) alignment
Range on Protein: 49-244
Range on HMM: 18-205/332.0
THYDWLKADSEHRLMEEYDDIQAVGSIVRMdQATNAeVNktKNrFNKILPYEHSRVKLMALKgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWR
  . | . .    .....|| | . ||    . ..| ||  .|   ||.||..  |.| . . . .  ||||  .   .  |.||    .  .    .|.
knhiwnrinqrinivadlddyqrllsiset.arlea.vn..rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwq

MIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKkGRSDTYGGSLEVSLQSELDYEHWITRTFMLQKNKMKREVIQLQFTSWPDHGVPEQTkPMLDFVK
|. |.||  ||.. . || . .|  .|.|.| .|     | |.|  .. .  .   || ..|.|     .|   ..  | .  .|     .| . |
mvleqkspaivqlledvelkleksdkyfpdk.treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye.dflalrk

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 142-322 9.7e-17 55.9 In-house 40-220 (255) alignment
Range on Protein: 142-322
Range on HMM: 40-220/255.0
TTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSelDYEHWITRTF----MLQKNKMKREVIQLQFTSWPDHGVPEQTK
| . ....|  .|.. .||..   | |..||..|.| .|     .   ..|.        . . ||     .| . |  ..|   ... |...  ||...
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PMLDFVKNVRErirnKcviKPVIVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
 .|  .| ||.        |.|.||||.|.||. ...  . . |     ..  . |  |   .. |.| .|.  ..|  |  |    ..|.
eilnilkvvrd....s...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 218-323 2.3e-16 54.5 In-house 216-344 (350) alignment
Range on Protein: 218-323
Range on HMM: 216-344/350.0
EVIQLQFTSWPDHGV---PEQTKPMLD-----FVKNVRERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ-----HMEDNDFV---------D-VCGV
.| |||.  |.| ..   ||.  ..|.       ... |   ..   .|..||||||||||||...|| | .     ..  ....         | .  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VCEMRMHRNYLVQTETQYIFIHDCLMDYF
| |.|  |  .||. .|.|||...|. ||
vnelrkqrismvqnldqfifiYeallfyf

subfamily_hpo-7_pd Subfamily hpo-7 141-323 5.4e-15 50.0 In-house 45-227 (263) alignment
Range on Protein: 141-323
Range on HMM: 45-227/263.0
ETTNDMWRMIWEKKSTIIVMMTKTVEGGKDKCHQYWPKKKGRSDTYGgSLEVSLQSELDyeHWITRTFML----QKNKMKREVIQLQFTSWPDHGVPEQT
.| . ....|  .|.. .||..   | |..|| .|.| .|     .   ..|.     .    . .|  |    .. |  ..| . ... |...  ||..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

KPMLDFVKNVRErirnkCviKPVIVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
. .|  .| .|.        |...||||.|.||.  .   . . |     ..  . |  |   .. |.| .|.  ..|  |  |    ..|..
reilnilkvarn.....s..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

subfamily_CG42327_pd Subfamily CG42327 247-322 9.5e-15 49.1 In-house 238-314 (319) alignment
Range on Protein: 247-322
Range on HMM: 238-314/319.0
RERIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
  |  ..    |..|||| ||||||. || |   ...|..   ||.  .|  .|  |   |.|  || ||.  |  |
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 260-321 2.7e-14 47.3 In-house 2-63 (69) alignment
Range on Protein: 260-321
Range on HMM: 2-63/69.0
IVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
.||||.| |||||.||.      .  . .||.   |  ||  |  .|  | .|||||| |..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 78-231 1.3e-13 45.2 In-house 88-234 (244) alignment
Range on Protein: 78-231
Range on HMM: 88-234/244.0
MDQATNAeVNKTKNRFNKILPYEHSRVKLMalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKtVEggkdKCHQYWP
| .| |   |  |||    ||.. .|| |   ||     |||| ..  .    |||  | || .|. |.|.|. |..  ..|..   ||    .  .|||
mkdafnp.nnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.ve....eedeywp

KKKGrSDTYGGSLEVSLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHG
  .   . |   . |.|    ..    .  . ..   |. .. .  .| . ||  |
dsep.lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 260-321 1.5e-13 44.9 In-house 1-62 (69) alignment
Range on Protein: 260-321
Range on HMM: 1-62/69.0
IVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMD
.||||.| |||||.||.      .  . .||.   |  ||  |  .|  | .|.|||| |..
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 217-323 4.7e-12 39.9 In-house 218-344 (349) alignment
Range on Protein: 217-323
Range on HMM: 218-344/349.0
REVIQLQFTSWPDHGVPEQTKPMLDFVKnVRE---------RIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQ--HMEDNDFVDV----------CGVV
 |..|||.  |.| ..    . .|  .. |..            ..    ...|||||| ||||... || | .  ..  |... .            .|
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

CEMRMHRNYLVQTETQYIFIHDCLMDYF
 |.|  |  .||  .|.|.|...|. ||
nelrkqrismvqnlaqfiaiyealLkyf

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 41-137 3.2e-11 37.2 In-house 4-95 (95) alignment
Range on Protein: 41-137
Range on HMM: 4-95/95.0
PVLLANIETHYDWLKADSEHRLMEEYDDIQAVGSIVRmdQATNAEVNKTKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPREYIACQG
|. .. . .|   ....|.. . .|.  |.          .  .| |  |||| .|.||. .||   .|  | ..||||| .. |.     |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapy..tvgsseanipknrflnifpydatrv...vlttkrdsdyinacfvdgyarkncyiaaqg

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 97-232 3.9e-11 37.4 In-house 3-126 (130) alignment
Range on Protein: 97-232
Range on HMM: 3-126/130.0
LPYEHSRVKlmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKtVEggkdKCHQYWPKKKgRSDTYGGSLEVSLQS
|..| ||..        . .||||...   .  .||.  | || .|. |.|.|. |.   ..|..   ||    .  .|||  .   . |   . |.|  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.ve....eedeywpdse.Plewyeediivtltd

ElDYEHWITRTFMLQKNKMKR---EVIQLQFTSWPDHGV
  |  . |  ...  ......    .  .| . ||  | 
r.defknikasnleiesdlneshqaltmfqisnwpsdgt

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 40-128 4.7e-11 36.7 In-house 4-88 (440) alignment
Range on Protein: 40-128
Range on HMM: 4-88/440.0
RPVLLANIethYDWLKADSEHRLMEEYDDIQAVGSIvRMDQATNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNS
||...|..    |... .   | .|.   .   |   .  . ..   || |||. .|| |.|||| |  .||  ..||||| || | .|
rpiivadf...adyvqnnrrsrafedewsllpsgls.qpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 258-319 1.2e-10 35.8 In-house 230-291 (297) alignment
Range on Protein: 258-319
Range on HMM: 230-291/297.0
PVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
...|||||||||.|  .  | . . .  .   ||  ..  .|  |  ||||  |. ...|  
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 82-180 2.3e-10 33.7 In-house 22-88 (169) alignment
Range on Protein: 82-180
Range on HMM: 22-88/169.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtktveGGKDKCHQYWPKKK
..  .|.||||    |   | ||||  .  .  .|||||                           |||||  ...||..     |. |   ..||.|.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwpeke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 82-180 2.9e-10 33.2 In-house 21-87 (169) alignment
Range on Protein: 82-180
Range on HMM: 21-87/169.0
TNAEVNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtktveGGKDKCHQYWPKKK
..  .|.||||    |   | ||||  .  .  .|||||                           |||||  ...||..     |. |   ..||.|.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpeke

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 87-170 4.8e-10 33.4 In-house 34-116 (332) alignment
Range on Protein: 87-170
Range on HMM: 34-116/332.0
NKTKNRFNKILPYEHSRVKLMALKGKSetDYINANYIPGFNSPREYIACQGPLPETTND-MWRMIWEKKSTIIVMMTKTVEGGKD
|   ||  ..  ..||||.|    ||   |. ||... |..    || .| |. . |.  .|||. |.| ..|...    |  | 
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr

subfamily_PTPDC1_pd Subfamily PTPDC1 208-317 9.4e-10 33.2 In-house 71-170 (182) alignment
Range on Protein: 208-317
Range on HMM: 71-170/182.0
FMLQKNKMKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVRERIRNKcvikPVIVHCSAGVGRTGTYIALDRLTQHMedndfVDVCGVVCEMRMHRNYLVQ
|  ........ |     .|.|.||.  .. .|| || |   ....     | ||| || ||||  ||   . ..      ..    .  .| .|   .|
fsYdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg....kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiq

TETQYIFIHD
| .|  ....
treqvelvke

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 85-162 1.1e-09 32.2 In-house 35-117 (347) alignment
Range on Protein: 85-162
Range on HMM: 35-117/347.0
EVNKTKNRFNKILPYEHSRVKLMALKGKS-----ETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMT
| . .||| ..    . .|| |   | |         |||| .|   |. .|||  | |||.|  |.|.|.   | | .| . 
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 224-323 1.4e-09 31.8 In-house 188-285 (302) alignment
Range on Protein: 224-323
Range on HMM: 188-285/302.0
FTSWPDHGVPEQTKPMLDFVKNVreRIRNKCVIKPVIVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDYF
.| |... ||..   .   ...|    ..  . .....    |.|| |. ..|    ....... . .  .|  .|  |   |.. .||.... .|. |.
ltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi





0038934 (Phosphotyrosine protein) phosphatases II 211-276 1.6e-09 33.2 In-house 71-135 (194) alignment
Range on Protein: 211-276
Range on HMM: 71-135/194.0
QKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRERIrNKCVIKPVIVHCSAGVGRTGTYIAL
 ......  |.     .||.|.. ... .|.|.. | | . |..  . | ||| ||.||||| .| 
dpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaa

PTEN_1 216-301 6.2e-09 30.9 In-house 92-173 (196) alignment
Range on Protein: 216-301
Range on HMM: 92-173/196.0
KREVIQLQFtSWPDHGVPEQTKpMLDFVKNVRERIRNK-CvIKPVIVHCSAGVGRTGTYIAlDRLTQHMEdNDFVDVCGVVCEMRMH
|. |..|.| ...|||.|   . ..|..|.. | .... .  . |.||| ||.||.|| .|   | ...   .. . .  |.|.|..
ksgveylhf.pieDhgapslse.lfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva.ayLmykgk.ltadeAlelvrekRpp

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 171-322 1.6e-08 28.4 In-house 149-301 (332) alignment
Range on Protein: 171-322
Range on HMM: 149-301/332.0
KCHQYWPKKKGRSDTYGgsleVSLQSELDYEHWITRTF--MLQKNKMKREVIQLQFTSWPDHG-VPEQTKPMLDFVKN--VRERIRNKCVIKPVIVHCSA
 |...||.|. . |       .|.|.  |.     .||   . ..|  .. . ..|  | |   .||    |   .|   .|   .   .| |... |..
icrkfwpekrskkdfpa....lsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLMDY
|| .   . ..| .  .. ..  | .   .  ..|.|   ..|   |    . || .
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 58-187 1.3e-07 25.3 In-house 24-149 (302) alignment
Range on Protein: 58-187
Range on HMM: 24-149/302.0
SEHRLMEEYDDIQAVGsiVRMDQATNAEVNKTKNRFNKILPYEHSRVKLMAlkgkSETDYINANY--IPGFNspREYIACQGPLPETT---NDMWRMIWE
 . .. .|.. |...   | ... .    |  ||. ...  ... .||| |    .. .|.||    .| ..  |. |  | |  ...   .. |||...
dtaevkkefkkidtmk..vdlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfq

KKSTIIVMMTKTVEGGKdKCHQYWPKKKGRSDTYG
.| . .|.. .. |  |   ....||| |   .||
ekivsvvilvgeeelkk.tlselfpkksgdykeyg

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 82-126 1.7e-07 25.1 In-house 32-77 (244) alignment
Range on Protein: 82-126
Range on HMM: 32-77/244.0
TN--AEVNKTKNRFNKILPYEHSRVKLMALKgKSETDYINANYIPGF
||    .| ||||. .|||....|| | . | |  .|||||||| | 
tnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs

subfamily_PTEN_pd Subfamily PTEN 211-312 2.6e-06 22.5 In-house 74-169 (184) alignment
Range on Protein: 211-312
Range on HMM: 74-169/184.0
QKNKMKREVIQLQFTswpDHGVPeQTKPMLDFVKNVRERIRNKCvIKPVIVHCSAGVGRTGTYIALDrLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTET
...|.. .|....|.   ||  | . . . ..|..... . ..   . |.||| || ||||. |.   | ...  ..  ..  .  |.|.. .  |.   
dskkfdgrvavypfd...Dhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPs

QY
| 
qr

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 130-188 4.2e-06 20.3 In-house 236-290 (440) alignment
Range on Protein: 130-188
Range on HMM: 236-290/440.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTKTVEggkDKCHQYWPKKkGRSDTYGG
  .|| | ||  |  |.||.. . . . |.|. .  .     |  ||| .  || |.| 
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvn.trsvtfgp

subfamily_VSP_pd Subfamily VSP 227-275 4.9e-06 20.6 In-house 101-147 (212) alignment
Range on Protein: 227-275
Range on HMM: 101-147/212.0
WPDHGVPEQtKPMLDFVKNVRERIRNKcVIKPVIVHCSAGVGRTGTYIA
  || ||.  . .| | |.|.| . .    . ...||  | ||||| . 
iddhnvpkl.eellvftkevkewlekd.lknvlaihckGGkgrtGtivc

PTPc_motif_SM00404 193-275 7.4e-06 20.9 In-house 21-99 (140) alignment
Range on Protein: 193-275
Range on HMM: 21-99/140.0
SLQSELDYEHWITRTFMLQ--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVrerirnKCVIKPVIVHCSAGVGRTGTYIA
 |...|. .| |  |   .  |.. .....|..        . .. . .|||..|.      .   . |.||| ||| |..| |.
allkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatlii