Gene PTPRB-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP069_AA protein Get Run
SpurP069_AA_40-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 34-321 2.3e-136 448.6 In-house 3-287 (293) alignment 
Range on Protein: 34-321
Range on HMM: 3-287/293.0
VSRPILLTDIDTHYDWLKADSENGLMKEYDNIQAVGSIVRMDQATIAEmNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQG
 |.|| |.....|.. .||||. ....||....|||.   ...|. |. |..|||...||||.||||||.|||..|..||||||||||.|||||.||.||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelav.nraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSvtCGGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTK
|||||..|.|||.|||||.||||.||.||.|| ||..|||. . .     |...|.|..| ..|.|..|.....|.|..|.| |..|||||||||||.||
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv..lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektk

PMLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
..||||..|||.|.|..  .|.|||||||||||||.||||||.|..|..|.||..|.|.|.|..||.|||||.||||||.|..|....
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPRD_pd Subfamily PTPRD 35-321 4.2e-112 370.6 In-house 2-283 (564) alignment 
Range on Protein: 35-321
Range on HMM: 2-283/564.0
SRPILLTDIDTHYDWLKADSENGLMKEYDNIQAVgSIVRMDQATiAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGP
|.||  ... .|.  |||.|.  ...|| .|.   . .....|. ...|| |||...|..|.||||.| ...|....|||||..| |......||| |||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaan.kpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgP

LPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkGnSVTCgGSLEVSLQSELDYEHWITRTFMLRK--NKMKREVIQLQFTSWPDHGVPEQT
|.||..| |||.||..|..|||.|...| ||.|||.|||.. | . |. |.|.|.|..| .... . ||| |.|  .. .||| | .|||||||||||..
laetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa

KPMLDFVKNVREHIrkKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
...||....||..   ..  .|.|||||||||||||.|..| . . ..... ||. ..| ..| .||..||||.||||||. .... ..
tslLdlirkvraln..epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 40-321 2.5e-98 324.0 In-house 4-282 (318) alignment 
Range on Protein: 40-321
Range on HMM: 4-282/318.0
LTDIDTHYDWLKADSENGLMKEYDNIQAVGSIVRMDQAtIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETT
. |...|   |... |  | .||.... . . |   .. . ..||.|||.. ||.|.|.||||  |.|. ..||||||||.|... ..|||.|.||||| 
vedleshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpeti

NDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVtcgGSLEVSLQSELDYEHWITRTFMLRKNKM--KREVIQLQFTSWPDHGVPEQTKPMLD
.|.|||.||..|..|||.||..| ||.|.|.|||... .|    |.| | |..|....... |.| ......  .|.| | ..|||||.||||..  .||
eDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsy...gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

FVKNVREhIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
.|..|.. . .|.  .|.||||||||||||..||.| | ......  ||| ..| ..| .|| .|||| ||.||.| |... .|
lvrqvsk.aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 43-320 1.6e-96 317.8 In-house 9-280 (288) alignment 
Range on Protein: 43-320
Range on HMM: 9-280/288.0
IdTHYDWLKADSENGLMKEYDNIQAVGSIVRMDQATIAeMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
. ..    .|....|. .||... |...    ...  |  |..|||.. ||||.. ||||  |. ....|||||.|| | .. ..||| ||||..| || 
v.akvakksarnrtgfseeynsLaalektksvtagrla.vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndf

WRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKgnSVTCGGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNV
|....|.|.. |||.|. ||||| ||..|||. .    .  ||..| |... . |....|...| |.| ..|. |.|...||||||||...|.|.....|
WelvyenktstivmltelveggktkCeeYWPdad..kpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqv

REHIRKKcvIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
     ..   .|..||||||||||||.|||| | ...| .|..||.|.|...|..|. ||||..||.||...|..  .
kvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 45-319 3.6e-95 313.3 In-house 4-276 (281) alignment 
Range on Protein: 45-319
Range on HMM: 4-276/281.0
THYDWLKADSENGLMKEYDNIQAVGsIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWR
.| . |......|...||....|.| .    .|. |. |..|||.. |  |...|||.   . ...|||||||..||.....||||.|||.|.. ...|.
khlkqlsqndnaGfieeyeklaaig.vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MIWEKKSTIIVMMTQTVEGGKDKCHQYWPkrKGNSVTCGGSLEVSLQSELDYEHWITRTFML-RKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVR
|.||.| ..|||.|. .|.|| |||.|||   .|| .  | . |. ..| . ...|.|.|.| |..  .||| ||..|.|||||||..|| .|.| |.|.
mvweqkvsaivmvtreieagklkChrYWP..ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevl

EHIRKKCViKPVVVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
.  .||    |.|.|||||||||||||||||| ...|..   .||. || |.| .||..||| .|| |..  ..| .
kltekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0051299 (Phosphotyrosine protein) phosphatases II 38-319 1.9e-94 311.6 In-house 5-286 (288) alignment 
Range on Protein: 38-319
Range on HMM: 5-286/288.0
ILLTDIDTHYDWLKADSENGLMKEYDNIQAVGSIVRMdQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPE
| ....  .. .|.|.. .||..|.. ....   . .  |.. . |..|||.  ||||.||||||  |.| ...|||||.||.|.|..|..||.|||||.
isveellklvlkllangltglleefeellsllpdltl.saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkGNSVTCGGsLEVSLQSELDYEHWITRTFMLR------KNKMKREVIQLQFTSWPDHGVPEQ
|..| |||.||.....|||.|..|| |. ||.||||   |.|.|.|  . | | ||  ......||....      ... .|.|.....|.|||||||. 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

TKPMLDFVKNVREHIRkkCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
....|||.. ||....     .|||||||||||||||.|||| | ...| .  |||...|. .|..|...|||. ||.|....|....
pellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 41-320 2.8e-94 311.2 In-house 27-300 (308) alignment 
Range on Protein: 41-320
Range on HMM: 27-300/308.0
TDIDTHYDWLKADSENGLMKEYDNIQAVGSiVRMDQATIAEMNKTKNRFNKILPYEHSRVKLmalkgKSETDYINANYIPGF--NSPREYIACQGPLPET
. .| .. . ||..  .|..|.  ...|   ..   ..  . ||.|||.  ||||.||||||     ....|||||.|..|.  ..||..||.|||||.|
svldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpnt

TNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCGGSLEVSLQSELDYEHWITRTFMLRK--NKMKREVIQLQFTSWPDHGVPEQTKPML
..| |||.|| ....|||.|..|| |. ||.||||   |..... | . | | ||  ......||..|..  ..  |.| ....|.|||||||......|
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

DFVKNVREHIRKkcviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
||.. ||.....    .|.|||||||||||||.|||| | ...| .  |||...|. .|..|.. |||. ||.|....|.....
dflelvrkslpg....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0046845 (Phosphotyrosine protein) phosphatases II 58-319 2.4e-92 304.6 In-house 2-274 (284) alignment 
Range on Protein: 58-319
Range on HMM: 2-274/284.0
LMKEYDNIQAVGSIVR-MDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGF-----NSPREYIACQGPLPETTNDMWRMIWEKK
|..|.  .. .   .     ..... |..|||.  ||||.||||||  |.|. ...|||||.|..|.     ......||.|||||.|..| |||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STIIVMMTQTVEGGKDKCHQYWPKRkGNSVTCGGsLEVSLQSELDYEHWITRTFMLRK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIR
...|||.|..|| |. ||.||||   |...|.|. . | | ||  ......||..|..   ..  |.|.....|||||||||......|.|.. |||...
vrvIVmltelvengrekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

KKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDND---FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
.    .|.|||||||||||||.|||| | ...| ..    |||...|. .|..|.. |||. ||.|....|....
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 43-321 1.2e-89 296.0 In-house 6-289 (563) alignment 
Range on Protein: 43-321
Range on HMM: 6-289/563.0
IDTHYDWLKADSENGLMKEYDNIQAVGSIVRMDQ-ATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSET-DYINANYIPGFNSPREYIACQGPLPETTN
   |   |.||.. |. .|....|       .|  .. .. || |||  .|..|..|||||  | || .. |||||||| |..  ...|| ||||..|..
fakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfd

DMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkGNSVTCgGSLEVSLQSELDYEHWITRTFMLRKNK--------MKREVIQLQFTSWPDHGVPEQT
| ||||||....||||.|. || |. ||..||||   .|.|. |.|.| |..|       .||..... |         ...|.| ..|.||||||||..
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desety.galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs

KPMLDFVKNVreHIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
 | | |||       .|  . |.|||||||||||||||.|| |.. ..... |.| |..  .|..||.||||| ||||.|| |..   |
lpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0040438 (Phosphotyrosine protein) phosphatases II 42-319 2.8e-89 294.8 In-house 4-276 (317) alignment 
Range on Protein: 42-319
Range on HMM: 4-276/317.0
DIDTHYDWLKADSENGLMKEYDNIQAVGSIvrMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTND
|.. .. .|.. . ..|..|. ... .       . .. . || |||.  ||||.||||||  |.|  ..|||||.|..|.| .|..||.|||||.|..|
dlllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

MWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkGNSVTCgGSLEVSLQSELDYEHWITRTFMLR--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||.|| ..|.|||.|...| |. ||.||||   |...|. | . | |.||  ..... ||...   ... .|.| ....|.|||||||. ....|||.
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

KNVREHIRKKCviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
. |||.....   .||.||||||||||||.||.... ...| . .|||  .|.|.|..|.. |||. ||.|..|.| ...
eavrealedpg..gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0047943 (Phosphotyrosine protein) phosphatases II 49-319 3.1e-89 294.3 In-house 5-272 (273) alignment 
Range on Protein: 49-319
Range on HMM: 5-272/273.0
WLKADSENGLMKEYDNIQAVGSiVRMDQATIAEMNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|..|.. .. .   .   .... . ||.|||.  ||||.||||||    | ...|||||.|..|.|..|..||.|||||.|..| |||.||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

KKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCGGSLEVSLQSELDYEHWITRTFMLRK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHI
.....|||.|..|| |. ||.||||   |. ..  | . | | ||  ......||..|..  .. .|.|.....|.|||||||......|.|.. ||...
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

R---KKcviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
.   ..   .|||||||||||||||.|||| | ...| .  |||. .|. .|..| . |||. ||.|....|....
ealpsn...gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 49-319 1.6e-88 292.1 In-house 6-277 (297) alignment 
Range on Protein: 49-319
Range on HMM: 6-277/297.0
WLKADSENGLMKEYDNIQAVGSIVRMDQATIAeMNKTKNRFNKILPYEHSRVKLmalkGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWE
. |... ..|.||.. .. .  .  .. |     |..|||.  ||||.|.||||    .....|||||.|..|.. .|..||.|||||.|..| |||.||
lekllflalllkefeellpllllgslsvallp.enleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

KKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCgGSLEVSLQSELD--YEHWITRTFMLRK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE
 ..|.|||.|. || |. ||.||||  .|.|.|. | . | |.|.    ......||. . .  |. .|.| ....|.|||||||| ....|||.. ||.
qnvtvIvmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

HIRK---KcviKPVVVHCSAGVGRTGTYIALDRLTQHME---DNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
....   .   .||.|||||||||.||.||.| . | .|    .  ||.. .|...|..|.  |||. ||.|....| ...
vlkllpsg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 37-319 3e-88 291.0 In-house 4-283 (319) alignment 
Range on Protein: 37-319
Range on HMM: 4-283/319.0
PILLTDIDTHYDWLKADSENGLMKEYDNIQAVGSIvRMDQATiAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.| . .. ...  |.. .|..| ||. ...  ..   .|.|.  | ||.|||.. ||.|...||.|..|.|. ..|||||..| |..  ...|| |.|| 
eievqeLkerlkalastgetllekefkllkeavnd.tfdsas.keenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

ETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKgnsVTCGGSLEVSLQSELDYEHWITRTFMLRK--NKM-KREVIQLQFTSWPDHGVPEQTK
.|..|.|||.||..| |.||.|. || .| |...|||. .   .. .| | | |..|   |..| | ..|.|  ...  ||| . |.|.||||.|||...
ntiedfWrmvWeeessivvmltklveklkvklkkywpeen...feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

PMLDFVKNVREHIRKKcVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
 .||..|..|.  .|.   .|.|||||||||||||.|.||   .... .  .||  .| ..|. || .||.. ||.||.. |... 
slldllkrirksrekt.qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
0039614 (Phosphotyrosine protein) phosphatases II 36-319 3.1e-88 291.3 In-house 12-289 (297) alignment 
Range on Protein: 36-319
Range on HMM: 12-289/297.0
RPILLTDIDTHYDWLKADSENGLMKEYDNIQAVGSivRmDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYIPGFNS-PREYIACQG
 || |. .| .. ..||.| ..|..|. ... .         .  . ||.|||.  ||||.||||||  ..|   ..|||||.|..|..  .|..||.||
ipiplsvldlllllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKdKCHQYWPKRKGnsvtCGGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTK
|||||..| |||.|| ..|.|||.|..|| |. ||.|||| . |    . | . | | ..  ......||. ...|.  |.| ..|.|.|||||||. ..
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsle

PMLDFVKNVREHIR---KKcviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
 .|.|.. |||...   |.   .||.||||||||||||.||.... ...| .  |||  .|.|.|..|.. |||. ||.|..|.|....
llleflelvrealaelpkg...gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0045450 (Phosphotyrosine protein) phosphatases II 35-319 2.5e-87 288.8 In-house 6-304 (307) alignment 
Range on Protein: 35-319
Range on HMM: 6-304/307.0
SRPILLTDIDTHYDWLKADSENGLMKEYDNIQAVGSI-VRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGK-SETDYINANYI--------PGFNS
|..| ..... ..  |..|. .|| ||.  .. |  . .    ..  . ||.|||.  ||||.|.||||. |.|. ...|||||.|.        .|...
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkGNSVTCGGsLEVSLQSELDYEHWITRTFMLR---KNKMKREVIQLQFT
.|..||.||||||| .| |||.||...|.|||.|..|| |. ||.||||   | ..|.|  . | | ||  ..... ||. .    .... |.|.....|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

SWPDHGVPEQTKPMLDFVKNVREHIRK---KcviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
.|||||||. ....|||.. ||.....   .   .||.||||||||||||.||.. . ...|..     ||.  .|...|..|   ||.. ||.|....|
gwpdhgvppsfeelldfieevrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

VDFF
 ...
lell
0043336 (Phosphotyrosine protein) phosphatases II 42-318 2.6e-86 284.8 In-house 6-276 (278) alignment 
Range on Protein: 42-318
Range on HMM: 6-276/278.0
DIDTHYDWLKADSENGLMKEYDNIQAVGSivRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTND
|.  .. .|....  .|..|. ... .     .   .. . ||.|||.  ||||.||||||  |.|   .|||||.|..|.| ||..||.|||||||..|
dllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

MWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPkrkGNSVTCgGSLEVSLQSELDYEHWITRTFMLR--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
 |||.|| ..|.|||.|. || |. ||.||||   |.|.|. | . | |..|  ......||. .   ... .|.| ......||||||||.....|||.
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggslty.gdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

KNVREHIRKKCviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
| |||.....   .||.||||||||||||.|||..| ...|.. .||.. .|.|.|..|   |||. ||.|....| ..
kavrealedsn..gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
DSPc_SM00195 59-319 2.3e-85 281.4 In-house 3-262 (263) alignment 
Range on Protein: 59-319
Range on HMM: 3-262/263.0
MKEYDNIQAVGSIVRMDQaTIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMT
 .|......  |  .... .. . ||.|||...||||.|.||||   ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|
keefekleestspkette.aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QTVEGGKDKCHQYWPKRKGNSVTCGgSLEVSLQSELDYE-HWITRTFMLRKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKcvIKPV
. .| || ||..|||. .|.. | | ...| |...  .. ..|.||. |.|..   .|.| |.|...|||||||..||..|.... |... ...   .|.
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
|||||||||||||....| . ...|... ||.. .|.|.|..|  .|||..||.||........
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 59-319 2.3e-85 281.4 In-house 3-262 (263) alignment 
Range on Protein: 59-319
Range on HMM: 3-262/263.0
MKEYDNIQAVGSIVRMDQaTIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMT
 .|......  |  .... .. . ||.|||...||||.|.||||   ..|...|||||||| | |....|||.|||||.| .| |||.||.|..||||.|
keefekleestspkette.aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QTVEGGKDKCHQYWPKRKGNSVTCGgSLEVSLQSELDYE-HWITRTFMLRKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKcvIKPV
. .| || ||..|||. .|.. | | ...| |...  .. ..|.||. |.|..   .|.| |.|...|||||||..||..|.... |... ...   .|.
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
|||||||||||||....| . ...|... ||.. .|.|.|..|  .|||..||.||........
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 50-320 1.1e-82 272.6 In-house 21-291 (298) alignment 
Range on Protein: 50-320
Range on HMM: 21-291/298.0
LKADSENGLMKEYDNIQAVGSIVRMDQATIAE--MNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIW
 |. .  |. .|. ....| | .. .. ..|.   || |||. .|.....||| | . ... |.||||| .. ...    .||.|.||.||..| |||..
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVtcgGSLEVSLQSELDYEHWITRTFMLRKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREh
|.... |||.|...| .| |.|.|||... .     |...|||.|. ..   |.|.... |.|   .||| ||.||||||.||||... .||....||  
eedigtiVmltnleeldktkyhkywPdegkety...geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.

IRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
 ....  |||.|.|||||||.||.||.| . .... .  |||  ||  .|..|  .||||.||.||..   ....
sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
Y_phosphatase Protein-tyrosine phosphatase 83-316 3.5e-82 270.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 83-316
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVT
||.|||...||||...||||   ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CGGsLEVSLQ-SEL-DYEHWITRTFMLRKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIrkKCVIKPVVVHCSAGVGRTGTYIALDRLT
.|  ..| |. .|  | .....|.. |.|.| .   ||| ||..|.||||||||..|..||....|...   .   .|||||||||||||||..||| | 
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 83-316 3.5e-82 270.7 In-house 1-234 (235) alignment 
Range on Protein: 83-316
Range on HMM: 1-234/235.0
NKTKNRFNKILPYEHSRVKLmalKGKSE-TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVT
||.|||...||||...||||   ||... .|||||||. |.......||.||||..| .| |||.|..|...|||.|. .| |. ||.||||.....|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CGGsLEVSLQ-SEL-DYEHWITRTFMLRKNKMK---REVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIrkKCVIKPVVVHCSAGVGRTGTYIALDRLT
.|  ..| |. .|  | .....|.. |.|.| .   ||| ||..|.||||||||..|..||....|...   .   .|||||||||||||||..||| | 
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
...|... |||. .|.|.| .|. .||...||||......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 37-318 9.7e-82 269.5 In-house 3-282 (305) alignment 
Range on Protein: 37-318
Range on HMM: 3-282/305.0
PILLTDIDTHYDWLKADSENGLMKEYDNIQAVGSIVRMDQatiAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.| | |....    ...|..|| ..|....  .. . ...    |.||.|||...| .....|..| . . . ..|||||.|. |...  .||. ||||.
iialddlaayikearvysdkgleaqykslyeeeesidvgk...keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

ETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCgGSLEVSLQSELDYEHWITRTFMLRK---NKMKREVIQLQFTSWPDHGVPEQTK
.| .| ||.|.| | . |||.|..||||||||.||||..|....   |...| |.||  .. .|.| . . .   .| .| |.|.|.|.|||||||... 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PMLDFVKNVREHIRKKcVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
 .|...|.|... .|    .|..|||||||||||..||.|   ....  . ||| .|. ..| .| ..|||  || |.|| | . 
sllslikrvqkdqkkd.kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN12_pd Subfamily PTPN12 53-322 1.1e-81 268.9 In-house 5-280 (290) alignment 
Range on Protein: 53-322
Range on HMM: 5-280/290.0
DSENGLMKEYDNIQAVGSIVRMDQ-----ATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIW
..|. . ||. ..... .  ....     |. .| |..|||.  ||||..|||.|   ... . ||||||.| | ... |||| |||||.| .| |||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

EKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCgGSLEVSLQSELDYE-HWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHI
||. .|.||. . || || ||..|||........  |..||.|..|   .  .. ||. ....| .|.| |...|.|||||||...|..|.....|||. 
eknveivvmaCrevelgkkkCerYWpeegeeelef.gefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelq

RKKcvIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHSD
...   .|.||||||||||||| ||.|   . ....     .||  .| |.| .|. ||||. || ... ........ 
ese..daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_PTPRA_pd Subfamily PTPRA 32-319 2.4e-81 268.2 In-house 8-295 (330) alignment 
Range on Protein: 32-319
Range on HMM: 8-295/330.0
NRVSRPILLTDIDTHYDWLKADSENGLMKEYDNIQAvGSIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIAC
|.   |. . ...   .  .||  . . .|.... | |.|    ...  | || |||. .||||..||| |  ..|. |.||||| .| |..   ..||.
nkkyfplpvekleeeirirsaddnklfreefnalPa.gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaa

QGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkGnSVTCgGSLEVSLQSELDYEHWITRTFMLR------KNKMKREVIQLQFTSWPD
|||. || .|.||||||.||. |||.|.  |  ..||.||||.  | .||  | . |... |   ...  | |...      ..| .| | |. ||||||
qGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvty.GnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPd

HGVPEQTKPMLDFVKNVREHIRKKCVikPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
 ||| ... ||...|.|..  ....   |.|||||||||||||.|.|| . . .. .  ||| ..| ..|. |  .|||. || ||.  | ...
vGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0045098 (Phosphotyrosine protein) phosphatases II 80-320 3.2e-80 264.7 In-house 30-273 (278) alignment 
Range on Protein: 80-320
Range on HMM: 30-273/278.0
AEMNKTKNRFNKILPYEHSRVKlmalkgksetDYINANYIPGFnsPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkGNS
 . |. |||.  ||||.|||||          |||||.||.|.  |...||.|||||.|..| |||.|| ..|.|||.|. ||.|. ||.||||   |.|
ylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggs

VTCgGSLEVSLQSELDYEHWITRTFMLR------KNKMKREVIQLQFTSWPDHGVPEQT--KPMLDFVKNVREHIR--------------KKcviKPVVV
.|. | ..| |.||  ......||....      .. ..|.| .|....|||||||...  |..|.... .||...              ..   .||.|
lty.gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg...gpvlV

HCSAGVGRTGTYIALDRLTQHMedNDFVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLVDFFH
|||||||||||..|.. . ...  .. ||.  .|.|.|..|..  ||.. ||.|....|.....
HCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 80-319 3.3e-80 264.5 In-house 8-246 (249) alignment 
Range on Protein: 80-319
Range on HMM: 8-246/249.0
AEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkGNS
 . || |||.  ||||.||||||  |.|   .|||||.||.|....|..||.|||||||..| |||.|| ..|.|||.|..|| |. ||.||||   |.|
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggs

VTCgGSLEVSLQSELDYEHWITRTFMLR--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRK---KcviKPVVVHCSAGVGRTGTYIALDR
... | . | | |.  ......||..|   ... .|.| ..|.|.|||||||. ....|||.. ||.....   .   .||.||||||||||||.||.. 
ley.gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkg...gpvlVHCsaGvgRtGtfiaayl

LTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
. ...| .  ||.  .|...|..|.. ||.. ||.|....| ...
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 80-318 2e-79 261.7 In-house 6-242 (245) alignment 
Range on Protein: 80-318
Range on HMM: 6-242/245.0
AEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkGNS
 . ||.|||.  ||||.|.||||.  .|   .|||||.|..|.. .. .||.|||||||..| |||.|| ..|.|||.|...| |. ||.||||   |.|
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

VTCGGsLEVSLQSELDYEHWITRTFMLR--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIR--KKcviKPVVVHCSAGVGRTGTYIALDRL
.|.|. . | | ||  ......||...   ... .||||......|||||||. .. .|||.. ||....  ..   .||.||||||||||||.||....
ltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsn...gpvlVHCsaGvgRtGtfiaaylm

TQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
 ...| .  |..  .| |.|..|   |||. ||.|....| ..
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Ptp69D_pd Subfamily Ptp69D 37-320 2.1e-79 261.8 In-house 3-287 (307) alignment 
Range on Protein: 37-320
Range on HMM: 3-287/307.0
PILLTDIDTHYDWLKADSENGLMKEYDNIQAVgSIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLP
.| . |... .   | |.. ||.|||....|   | .  ...  . |. |||...| .... ||||  ..|| ..|||||..| |..  ...|| |.|. 
aiaiddleealksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkgnSVTCGGSLEVSLQSELDYEHWITRTFMLRKNK-------MKREVIQLQFTSWPDHGVP
.| .| ||||.|...|.|||...  |  ..||..|||.      .  |.. | | ||   ...| |.. . |.|        .|.|.| ..|.|.|  ||
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

EQTKPMLDFVKNVREHIRKKcvIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
|... .|.....|||. ...    |.||||||||||.|...||| | |... .| ||.. .|...| .|| |||   ||.|..  |.|. .
evargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN9_pd Subfamily PTPN9 43-319 3.2e-79 261.0 In-house 3-290 (297) alignment 
Range on Protein: 43-319
Range on HMM: 3-290/297.0
IDTHYDWLKADSENGLMKEYDNIQAVGSIVRMDQAtIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDM
|.   ...|.  ..||.||| .|..     .....    .| .|||.. .| |...||.|  .......||||||.. |.. .. .|| ||||..|..| 
ieelvayvkekgkrGlskeyaeirnepveGtflas.klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCgGSLEVSLQSELDYEHWITRTFMLR--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
|||.||..  .|||.|..|| |. || ||||. ...|    |.|.||  .   .|.. .|.. ..  |.. .|.|.  ||.||||.|||.... .||...
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaef.gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

NVREH-----------IRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
.|||.            . ..   |.|||||||.|||||.|.||   ...|. . |||. .|  .|  | . .||. || | . ..... 
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 36-319 1.3e-78 259.2 In-house 4-279 (315) alignment 
Range on Protein: 36-319
Range on HMM: 4-279/315.0
RPILLTDIDTHYDWLKADSENGLMKEYDNIQAvGSIVRMDQATiAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPL
.|| | .. |.    || ..||. ..|..|   | .  .| |    .|| |||. .|..|..|||.|  |. ....||.|||.|.|.| .| |||.|||.
qpipldqlityvaqkkastkngfkqdyesipg.gqlhpldvak.kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

PETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkgnSVTCgGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPM
... .|.||...|.. . |||.|..||| | |. .||| .    |.  | . |...||  ....  ||.    ..  |||.||..||||| |||. | |.
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviy.Gkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytipl

LDFVKNVREHIRKKCviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
......|. |  ..    ..|||||||||||||.|.|| . ...| .. .||  ..  .|  |  .||.  || ||.| |.. |
mnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_PTPN3_pd Subfamily PTPN3 58-320 5e-78 256.9 In-house 17-276 (280) alignment 
Range on Protein: 58-320
Range on HMM: 17-276/280.0
LMKEYDNIQAVGSIVRMDQATIAEmNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYI----PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTI
........      . ...|  .| | .|||.  ||||.. ||||     .||||||||||.    |. .    |||.||||..|..|.|.|.||.||..
vlaqfeqlyrkkpglaisaarkpe.nlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

IVMMTQTVEGGKDKCHQYWPKrKGNSVTCGgSLEVSLQSELDYEHWITRTFMLRKNK--MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHirKKCV
|||.|..|| |. |||||||. ...... | ...| ...|   . ...| ..|....   .|...|||...|||||||.... .|.||..||.   ..  
ivmlttlverGrvkChqyWPe.tedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgk

IKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
 .|||||||||.|||| .|.|.   . .| .. | .  .| .||  |  ||||..|| |. ....  ..
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPN6_pd Subfamily PTPN6 55-319 2.1e-77 255.2 In-house 25-297 (306) alignment 
Range on Protein: 55-319
Range on HMM: 25-297/306.0
ENGLMKEYDNIQAVGSIVRMDQAT-IAEMNKTKNRFNKILPYEHSRVKLMaLKGKSETDYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKS
 .|...|....|   .  ....       ||.|||.. |||..|.||.|   .. ...||||||||     .| ..||| || |..| .| |||.|...|
kagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

TIIVMMTQTVEGGKDKCHQYWPKRKGNSVtcGGSLEVSLQSELDYEHWITRTFMLR---KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRK
..|||.|. || ||.|| .|||. . ..    |...|.  || . ...| |....    |.| .|||.|..|.||||||||.... .|||...|... ..
rvivmttkevErgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

KC--VIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
       |.|||||||.|||||.| .| |.. .| . .   .|.  .|  .| .|. |||||.|| |..  .  . 
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 58-324 3.2e-77 254.9 In-house 36-299 (319) alignment 
Range on Protein: 58-324
Range on HMM: 36-299/319.0
LMKEYDNIQAVGSIV-RMDQATIaEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVM
|  |. ..  .|     .. | . . || |||. .||......|||  | |.  .||||| .. |. ..  |||.||||..| .|.|||||| ... ||.
levefrracklgvnladqtfanl.dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

MTqtveggKDKCHQYWPKRKgnsVTCGGSLEVSLQSELDYEHWITRTFMLRK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKCVIK
.|      |||| ||||..    |   .  .|...|  . . .. | . | .   .| .|.. |  |  |||.|||... ... .||.||   .|.   .
lt......kdkcsqywplki...vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD---FFHSDVA
..||||||||||||.||.|| | . |.... |||  .| ..|  || |||  .|| ||.  |..   | |||||
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_PTPN13_pd Subfamily PTPN13 60-317 1.9e-76 252.0 In-house 15-267 (273) alignment 
Range on Protein: 60-317
Range on HMM: 15-267/273.0
KEYDNIQAVGSIVRMDQATIaEMNKTKNRFNKILPYEHSRVKLMALKGksetdYINANYIP--GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
.|..... . .. . ...   . ||.|||. ..|||...|||| .  |     ||||..|     .   ||||||||||||..|.|.|.||.|...|.|.
eefkelrelkpldtcevgkk.kenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQTVEGGKDKCHQYWPKRKGNSVTCGGSLEVSLQSELDYEHWITRTFMLRKNKM--KREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREhIRKkcVIKPV
|. .|.|| |||.|||..|.....  . |||.|    ... .  |........    ||| .|.|..||||||| .....| ||..||. ...     |.
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqt..dagPi

VVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD
|||||||.||.||.|..| . . .| .  .||  .| ..|  |. .|||. ||||..  ...
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 76-324 8.6e-76 250.1 In-house 19-263 (284) alignment 
Range on Protein: 76-324
Range on HMM: 19-263/284.0
QATIaEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTqtveggKDKCHQYWPKR
 | . . || |||. .||......|||  | |.  .||||| .| |. ..  |||.||||..| .|.|||||| ... ||..|      |||| ||||..
fanl.dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

KgnsVTCGGSLEVSLQSELDYEHWITRTFMLRK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIAL
    |   .  .|...|  . | .. | . | .   .| .|.. |  |  |||.|||... ... .||.||   .|.   ...||||||||||||.||.|
i...vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD---FFHSDVA
| | . |.... |||  .| ..|  || |||  .|| ||.  |..   | |||||
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 79-319 5.1e-75 247.5 In-house 39-276 (515) alignment 
Range on Protein: 79-319
Range on HMM: 39-276/515.0
IAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGN
  |.| .|||.. ||||. .||||  .. . . ||.|| |||.|.. . ||| |||.. ...|.||...... | |.|.|.  || | || .|||.. |.
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

SVTCgGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKCviKPVVVHCSAGVGRTGTYIALDRLTQH
||   ||..|.| |       | |.. . |..  | | | .|| |||.|||..|. .| ..|.|.    .     |...|||||||||| .|..|    |
svkf.GsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvah

MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
... . |||  .|  .| .| |||||. || ||.. . . .
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 76-319 2.1e-74 245.1 In-house 22-268 (274) alignment 
Range on Protein: 76-319
Range on HMM: 22-268/274.0
QATIAeMNKTKNRFNKILPYEHSRVKLMALKGKSE-TDYINANYIPGFNS-PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWP
. ...  ..||||...||| |.||| | . ....| ..||||||| |..   . |.| |||||.| .|.||||.......|||.|.  |  ..||..|.|
eldvf.gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

KRKGNSVTC-GGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKC-VIKPVVVHCSAGVGRTGTYIA
....  ..   | .|.  .. .. ...  |...|.. . .|.|.   .|.|||| .|......||.|..|.|  ...   . |||||||||.|||| .||
daedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

LDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
 .   ...... .||| ..||..|..|  .|||. || .||  |. . 
isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
0037934 (Phosphotyrosine protein) phosphatases II 79-318 4.3e-74 244.4 In-house 6-241 (243) alignment 
Range on Protein: 79-318
Range on HMM: 6-241/243.0
IAEMNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIPGFnsPReYIACQGPLPETTND----MWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPk
. ..|..|||.  ||||.||||||      . .||||||.|...  || .||.|||||||..|     |||.|| ..|.|||.|..|| |. ||.|||| 
llpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

rkgNSVtCGGSLEVSLQSELDYEHWITRTFMLRK---NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRK---------KcviKPVVVHCSAG
   ..| . | ..| | ||  ..... ||..|.    .. .|.||......|||||||. ....|||.. |||.|..         .   .||.||||||
...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg...gpvlVHCsaG

VGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRNY-LVQTETQYIFIHDCLVDF
||||||.||.. . ...   . ||.  .|...|..|..  |||. ||.|....|  .
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 82-317 3.6e-73 240.9 In-house 8-240 (250) alignment 
Range on Protein: 82-317
Range on HMM: 8-240/250.0
MNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDkCHQYWPKRKGnsvT
 || |||. .|.....||| |   ||  |.||||| .. |..  . .|| ||||..|..|.|||..|.||. |||.|. .| .|  .|||||  |    .
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka...e

CGGSLEVSLQSELDYEHWITRTFMLRKNKMKRE--VIQLQFTSWPDHGVPEQTKPMLDFVKNVREHiRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHM
  |.. ||| |.  .  ...|...| |.| . |  | ||.|..||| ||||... .|...|.|.   ....  .||.|.|||||||.|..||.| . ...
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqas.qqqagnaPvivqCsaGvgrsGafiaidavlerl

EDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD
. .  |||  |.  .| .|   |....||.|..  .  
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 78-320 6.4e-73 240.3 In-house 39-278 (315) alignment 
Range on Protein: 78-320
Range on HMM: 39-278/315.0
TIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKG
.  ..| .|||.. |||....||||  .  . . ||||| ||..... . ||| ||||. . .|.|||....| | |||.|.  || | || ||||.||.
aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

NSVTCGgSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHirKKCVIKPVVVHCSAGVGRTGTYIALDRLTQ
.||  | |..|.| |       ..| ...|| . .| | | ||| |||.||..||  .| ..|.|.    ..    ...|||||||||||  |..|   .
dsvefG.sikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidevva

HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
...... |||  .| ..| .| |||||| .| ||.| . . ..
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRK_pd Subfamily PTPRK 41-317 1.7e-72 238.9 In-house 7-275 (314) alignment 
Range on Protein: 41-317
Range on HMM: 7-275/314.0
TDIDTHYDWLKADSENGLMKEYDNIQAVgsivrMDqATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTN
 |.  .   ||.    |. .||...         | |.  . |..|||...||.|..|||.|....| ...|||||..| ... |...|. ||||.||..
adllqsiallkraegygfkeeyeslfeg.....wd.aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkgNSVTcGGSLEVSLQSELDYEHWITRTFMLRK----NKMKREVIQLQFTSWPDHGVPEQTKPML
|.||........ |||.|. || |. || .|||.   .. .  | ..| | .    .  ..|.| ..|     . .||| |.||..||||.|| . . .|
dfWrlvydencasivmltelvevgrvkClkyWPe...dtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

DFVKNVREHIRKkcVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD
..|..| ..  .     ..||||||| |||||.||.| . . .| .. |||  .| ..| ..  .|.|| ||.||.| ...
klvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 82-320 2.6e-70 231.5 In-house 19-265 (270) alignment 
Range on Protein: 82-320
Range on HMM: 19-265/270.0
MNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSV
 .|. ||.. |||  ..||.|  |. .|.| ||||||..||. ....||| .|||| |... ||||||.|.| |||.|. .| |..|| .|||......|
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

TC-GGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTK------PMLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIALD
..  | ..|  .||   | .|..   |...  .|...  ....|||||||...        .|  ...||.. ...   .|..|||||||||||| ||||
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
  .. .| .  |||  .. |.| .|  |||.  || |..  .| . .
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 41-321 3.3e-69 228.5 In-house 8-290 (325) alignment 
Range on Protein: 41-321
Range on HMM: 8-290/325.0
TDIDTHYDWLKADSENGLMKEYDNIQAVGSIVRmdQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTN
 ..  | .  ||. ..|. .|.. . ....| .  ...    || ||||. ......||| | ..| ....|||||.|.  .     ..|.| ||..|.|
vnlvehvekkkaqdqdgfahefgllpsddgiak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DMWRMIWEKKSTiIVMMTQTVEGGKDKCHQYWPKRKGNSVTCGGsLEVSLQSELDYEHWITRTFMLRKNKMK--REVIQLQFTSWPDHGVPEQT---KPM
|.||.. . ... .|...  ...|||.| .||||. |.|.| || |||.|..  ..  .. | . ... |    | | |.|. ||.| ||...     ..
dlWrlvldWrcs.vvvvlneldlgkdrcavywpkemgksktfGg.levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LDFVKNVREHIRK-KCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
|. ||.| | ..       |..|||||||||||..|.|  . ... ..  ||. |.|  .| .|  .|.|  |||.|...||... |
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_PTPN14_pd Subfamily PTPN14 55-320 1e-66 220.0 In-house 22-297 (300) alignment 
Range on Protein: 55-320
Range on HMM: 22-297/300.0
ENGLMKEYDNIQAVGSIVRMdQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKsETDYINANYIPGF--NSPREYIACQGPLPETTNDMWRMIWEKKST
|  . .||..|.       . ...  . |. ||||...||||..||.|.. | . .|.||||  |      . |.||..||||. | .|.|.|.||.. .
egkvfteyeripkkredall.staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

IIVMMTQTVEGGKDKCHQYWPKR--KGNSVTCgGSLEVSLQSELDYEHWITRTFMLRK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK---NVREH
.|||.|.. |.||.|...|.||   | ..|.  |  .|. .   | .  ||... |.    | .|.|. ||.| ||||||||  |..|....    ||..
livmlteeeedgkeksfkyfPkleskkktvef.gkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

IRKKC----VIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
  ..     .  ||.|||||||||||  |  | |.. .| |. .|.  |.  .|  | .|||| .|| |... |. ...
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 70-321 3.4e-66 218.4 In-house 38-286 (297) alignment 
Range on Protein: 70-321
Range on HMM: 38-286/297.0
SIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKdKCH
. .. .  .   .|  |.|.. ||||. |||||  .  . . ||.|| ...|..   ..|. | | ..| .|.|.|..... ..|||...  |. | || 
aniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kca

QYWPKrkgNSVTCGGSLEVSLQSELDYEHWITRTFMLRKNK--MKREVIQLQFTSWPDHGVPE--QTKPMLDFVKNVREHIRKKCVIkPVVVHCSAGVGR
.||..   ..||  |.. | |.|  . |  | |.. ..|.|  ..| | | ||..|||. |..  ... .|.....||..  ..    |..|||.|||||
ryWsd...kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGr

TGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
|| ....|    ...... ||. |.|  .| .| |||||. || |..  ..... |
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPN23_pd Subfamily PTPN23 72-316 6.7e-66 217.0 In-house 32-277 (288) alignment 
Range on Protein: 72-316
Range on HMM: 32-277/288.0
VRMDQATIAEMNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQ
 |    .||... .|||.. ||||.|.||||     .|. ||||| .. .  .   ..|| |.||..| || |.|..|.|| .|||...  | || |...
arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPKRKGNSVTCGGsLEVSLQSELDYEHWITRTFMLRKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRE--HIRKKCVIKPVVVHCSAGVGRT
|||..||..|. |  |.|.|.|. . |... |.. |. .  . ...|  ||.||||..|||.  . .|.|...|..  . ... . .|.|||||||||||
YwPedkgetvkfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRt

GTYIALDRLTQH-MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
|..  .    .   ..|  .|.  ||  .|  | . ||...|. |  .  .
gvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 52-319 1.2e-65 216.2 In-house 16-283 (290) alignment 
Range on Protein: 52-319
Range on HMM: 16-283/290.0
ADSENGLMKEYDNIQAVGSIVrMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSE--TDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEK
|  ..|  ...  ...  |     .  ... ||..|||..|..|.  |. |  . |. .   .|||| || |..  ..||| |||...|  | |..||..
akgnegfrnqfkmldsgeseh.tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

KSTIIVMMTQTVEGGKDKCHQYWPKRkgNSVTcGGSLEVSLQSELDYEHWITRTFMLRKNKM---KREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHI
|.|||||.|. .| ||.||.||||..  .. .  |  .. |..|  ... |.|.. .....    |..|.|.|.|.|...|  .... .|  .... .  
kvtiivmltniieegkvkCqqYWpds..dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq

RKKCvIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
||.   ...|||||..|||.....|..   .... .  .||  |. ..|. .  .|||. || .|.. ..  .
rkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 83-316 2.5e-64 211.7 In-house 3-236 (237) alignment 
Range on Protein: 83-316
Range on HMM: 3-236/237.0
NKTKNRFNKILPYEHSRVKLMALKgkSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkgNSVT
|| |||. .|  |.|||| |      |..|||||.|. ||. .|..|||.||||  . .|.|.|.|..| ..|||.|  .|| . |||.|||.   .  .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst..dqpa

CGGSLEVSLQSELDYEHWITRTFMLRKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQH
. | | |||. . ..  .  |...| |.  ..||    | |||||||.|||.||  .| | ||. .. ..     | ..|||||||||| .. .| . ..
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

MEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
 ...  ||.   |  .   | |..||. ||.|||. ..
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 52-320 8.1e-64 210.4 In-house 16-279 (287) alignment 
Range on Protein: 52-320
Range on HMM: 16-279/287.0
ADSENGLMKEYDNIQAVGSIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKS
| ...| .. .  .. |.        .||. || |||...||...  || |     . . ||||| .| |... ...|....|. .|  ..|..|.... 
akgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnv

TIIVMMTQTVEGGKDKCHQYWPKRKGnsvTCGGSLEVSLQSELDYEHWITRTFMLRKNK---MKREVIQLQFTSWPDHG-VPEQTKPMLDFVKNVREHir
|.|||..|  |  ...|.||||. |    .. |  ...| .|  ....| |.. .....    |..| | |.|.|...| |.|.   .| . . ....  
taivmlcqekendeevcyqyWpeeks...vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq..

KKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
.|    ..|||||..|||.....| .   .. . .  .||  |. ..|. .   ||| .||.|| | .. . .
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 42-321 2.1e-62 205.5 In-house 11-279 (287) alignment 
Range on Protein: 42-321
Range on HMM: 11-279/287.0
DIDTHYDWLKADSeNGLMKEY---DNIQAvgsivrmdqatiaemnKTKNRFNKILPYEHSRVkLMALKGKSETDYINANYIPGFNSPREYIACQGPLPET
|.|  .| || || ..    .   ... |                  |||. ..||....|| |.. .|.  .|||||||.....   ..||.|||.. |
dvdkevdalkeds.esstatfkaaeelaa................vkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaat

TNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkGNSVTCGGSLEVSLQSELDYEHWITRTFMLRKNKMKR--EVIQLQFTSWPDHGVPEQTKPML
 .|.||...|..|. ...||. || .. ||..|||.|    .  ||   | |. .    .. .|.. | . . .    | ||.. ||||....  .  ..
vrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavgli

DFVKNVREHI---RKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
 || .|..||   |.   . |.|||...|.||.|...|.  | . .||   |||  ||  .|..|. |||.  |. .. . || ....
rfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_PTPN1_pd Subfamily PTPN1 79-312 4e-61 201.3 In-house 28-264 (290) alignment 
Range on Protein: 79-312
Range on HMM: 28-264/290.0
IAEMNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKG-
  . |...||.  . ||.|||.||     ....|||||. .   .  |.||  |||||.|.. .|.|.||.||  .||. . || .. ||.||||. .  
klpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

NSVTCG-GSLEVSLQSELDYEHWITRTFMLRK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIALDR
.....   .|.| | || ...... |.. | .   .  ||...  .|.||| ||||    .|.|. .|||    .    |.|.|||||.||.||.. .| 
kellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

LTQHMEDNDF---VDVCGVVCEMRMHRNYLVQTETQYIFIH
.  ..|..|    ||.  |..|.| .|  |.||  |  | .
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 43-317 4.7e-58 191.7 In-house 7-277 (439) alignment 
Range on Protein: 43-317
Range on HMM: 7-277/439.0
IDTHYDWLKADSENGLMKEYDNIQAVGSIVRMDQATIA-EMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTND
.. | . |. . .. . .....|...    . . . .| | ..||||.... ...|.|| |  . |   . ||||||| |.  .. |||.|||  |||.|
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettdd

MWRMIWEKKSTIIVMMTQTVEGGKdkchqYWPKrkgNSVTCGGSLEVSLQSELDYEHWITRTFMLR----KNKMKREVIQLQFTSWPDHGVPEQTKPMLD
.||...|||.. |||.|. ||  |     |||    .. .| | . |  . ...  ... | | .     ... .| |.|.....|||. || |.  .||
fwrlviekktvtivmltnlvesyk.....ywps...daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FVKNVREHIRKKcVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD
|.. .     |.  . ||||||||||||||| ||||   ...  .. ||. |.|  .| .|. .||.  ||.||......
flrainsandke.eygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_PTPRN_pd Subfamily PTPRN 54-317 5.4e-57 187.8 In-house 27-290 (297) alignment 
Range on Protein: 54-317
Range on HMM: 27-290/297.0
SENGLMKEYDNIQAVGSIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPRE--YIACQGPLPETTNDMWRMIWEKKS
 .. | ||.. . |  .  .  ... || | .||| ...|||.|||||| .   ....|||||  |   . ||.  |||.||||..|  |.|.|.||. .
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGv

TIIVMMTQTVEGGKDKCHQYWPKrKGNSVTcgGSLEVSLQSEL-DYEHWITRTFMLRK--NKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRK
..||..|.  | |  .|..|||. .|..|   .  || | ||    . .. |.| |.   ..  | | |. | |||..||| ..|..|.| . |    | 
vvivnltrleeegvkqckrywpd.eGsevy..hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG

KCVikPVVVHCSAGVGRTGTYIALDRLTQHMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD
..   |.|||||.|.||||.||..| . ...      .|..  .  .|  |. ||.|. |. |.  ....
rsc..pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 80-314 1.5e-56 186.3 In-house 5-236 (239) alignment 
Range on Protein: 80-314
Range on HMM: 5-236/239.0
AEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkgN
  .||.|||. .|. |.|||| |  |     .|||||.|.  .. ||. ||| || .  .. |.|||.|...  .|||.|  .|| | |||||||     
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..t

SVTCggSLEVSLQSELDYEHWITRTFMLRKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIrkKCVIKPVVVHCSAGVGRTGTYIALDRLT
|  |   | |.|.    .  .| |||.. .     .| | | .|| |||.|||. .  .| . ... .        .| |.||||||||||... .| . 
skyc..nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds..lpgarpwvihcsagvgrtgaflvidaml

QHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDC
.. . .  ||.   |  .|  | ..|||  ||.||| .
rqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 81-315 1.6e-56 186.1 In-house 5-236 (239) alignment 
Range on Protein: 81-315
Range on HMM: 5-236/239.0
EMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkgNS
 .||.|||. .|. |.|||| |  |     .|||||.|.  .. ||. ||| || .  .. |.|||.|...  .|||.|  .|| | |||||||     |
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..ts

VTCggSLEVSLQSELDYEHWITRTFMLRKN--KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIrkKCVIKPVVVHCSAGVGRTGTYIALDRLTQ
  |   | |.|.    .  .| |||.. .     .| | | .|| |||.|||. .  .| . ... .        .| |.||||||||||... .| . .
kyc..nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds..lpgarpwvihcsagvgrtgaflvidamlr

HMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
. . .  ||.   |  .|  | ..|||  ||.||| ..
qakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_CG7180_pd Subfamily CG7180 80-318 1.6e-55 182.9 In-house 39-289 (296) alignment 
Range on Protein: 80-318
Range on HMM: 39-289/296.0
AEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKdKCHQYWPKRKgns
 . |. |||  |..||.. || |  |.|....||||| |. .|  ..|||  ..|  || .. ||.......  .|..|.| .  | ....|||..    
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...

VTCGGSLEVSLQSELDYEHWITRTFMLRKN------K------MKREVIQLQFTSWPD-HGVPEQTKPMLDFVKNVREHIRKK---CVIKPVVVHCSAGV
 .  | ..| . .|  | .  .||| | |.      .       .| | ..|.| |.  . ||  |. ...... ||  ..|     . .||||..| |.
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
.|.| |.|.|   . .| .. ||| . |  .| .|. ||.. ..| .| | | ..
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 74-316 3.1e-55 182.2 In-house 36-233 (392) alignment 
Range on Protein: 74-316
Range on HMM: 36-233/392.0
MDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGkdkchqywp
 ....  |.|. |||...||||. .||||  .   ...||.|| |||.|.. . |||.||| . . .|.|||..... | |.|.|.  ||          
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

krkgnsvtcggslevslqseldyehwitrtfmlrKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKkcVIKPVVVHCSAGVGRTGTYIALD
                                  | . .| | | .|| |||..||..|  .| |.|.|. .  .    .|...||||||||||  |..|
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq..ythpliihcsagvgrtgvvisid

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
 .  | .   .|||  .| ..| .| |.|||. || ||. ...
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 61-315 3.4e-53 175.4 In-house 11-262 (283) alignment 
Range on Protein: 61-315
Range on HMM: 11-262/283.0
EYDNIQAVGSIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKGksetDYINANYIP---GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
 ..... ..   .  . . |. ||.|||...|.|..  ||.| ..      ||||| .||     .  ..||..|.|| .|  |.|.|....| | |||.
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TQTVEGGKDKCHQYWPKRKGNSVtcgGSLEVSLQSELDYEHWITRTFMLRKN---KMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVreHIRKKCVIKP
|.  |. . || ||||||        | . |.|. |   . .| . ..||.|   | .  .   |.  | . |       .. | | .    ...    |
tklqedlrikCsqyWPkrGsedy...GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvi..slqteskkgP

VVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
.|||||.|.|||...||.    ...  .  |||  ||  || .|  .|||  || ..|.  
ivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0051429 (Phosphotyrosine protein) phosphatases II 111-321 8.6e-53 175.0 In-house 4-227 (272) alignment 
Range on Protein: 111-321
Range on HMM: 4-227/272.0
TDYINANYIPGFNS---PREYIACQGPLPETTNDMWRMiWEKKSTIIVMMTQTVEGGKDKCHQYWP---------KRKGNSVTCGGSLEVSLQSELDYEH
..||||....|...   |. .....|||| | .| ||. .| . . ||......| |..||..|||            .      | | | |.||  ...
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

WITRTFMLR---KNKMKREVIQLQFTSWPDHGVPEQTkpMLDFVKNVREhirkkcvIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVD--------V
.| |...|.   .... ||| .|..|.|||||||...  .|.... ...        .||.||||||..||||..||..| . ..... ||        .
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

CGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
 ..| |.| .| . ||||.||.|....|.... |
eeaveelraqrpgavqteeqylflyeallellrs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 54-319 1.7e-52 173.0 In-house 13-293 (301) alignment 
Range on Protein: 54-319
Range on HMM: 13-293/301.0
SENGLMKEYDNIQAVGSivRMDQATIAEMNKTKNRFNKILPYEHSRVKLMALKG--KSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKS
 .|.. ..|.... . .  .  . .. |.||. |||..| .|.. |. |   .   .....||||.|| |... ...|| |||. .|  |.||.||..| 
hsnkfeeqykelkeged..ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCgGSLEVSLQSELDYE-----------------HWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKP
. |||.|.. || |.||.||||. . .| .  | ..| |..|  |                    | |.|  ...|  ..|.||| |.||..||  . . 
vsivmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

MLDFVKNVReHIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
.|  . .|  | ..|    |||||||..|.|.|.|....        .  ||| .|.  .|  .   |.|  ||..|.| .  ..
vLqviddvi.hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
0041856 (Phosphotyrosine protein) phosphatases II 83-320 6.3e-52 171.1 In-house 1-172 (182) alignment 
Range on Protein: 83-320
Range on HMM: 1-172/182.0
NKTKNRFNKILPYEHSRvklmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTqtveggkdkCHQYWPkrkgnsvtc
|..|||. .||||.|||            ||||||.. |   ....||.||||..|..|..||..| . |.||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ggslevslqseldyehwitrtfmlrkNKMKREVIQLQFTSWPDHGVPEqTKPMLDFVKNVREhirkkcVIKPVVVHCSAGVGRTGTYIALDRLTQHmedn
                          .. .|..||.....|||||||. .  .|||.. |.|        .||.||||||||||||..|.. . ..    
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

dFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
  |..  .|...|..|.  |.|. ||.|....| ....
.gvsleeavklvrsrRpgmvitpnqyfflqlallelll
0036282 (Phosphotyrosine protein) phosphatases II 111-313 2.9e-49 162.4 In-house 2-164 (174) alignment 
Range on Protein: 111-313
Range on HMM: 2-164/174.0
TDYINANYIPGFNSPREYIACQGPLPettndMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKrkgnsvtcggslevslqseldyehwitrtfmlRKNK
.|||||... ..  ....||.||||.      |.|..| ..|..||... .| |. ||..|||                                 ... 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

MKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVREHIRKkCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEdNDFVDVCGVVCEMRMHRNYLVQTETQYIF
..|..||.... |||||||. .. .|.||| |.|.. . .  .||.|||||||||||| .|.... .... ...||.. .| |.|..| . |||. ||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IHD
...
lyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 49-319 2.5e-47 156.4 In-house 6-277 (307) alignment 
Range on Protein: 49-319
Range on HMM: 6-277/307.0
WLKADSENGLMKEYDNIQAVGSIVRMDQA-TIAEMNKTKNRFNKILPYEHSRVkLMALKGKSeTDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIW
|..   . |. .  |... .        .    . |  |||.. .   ...|. .. ..| . .||| |||.     |. .|..|||| .|  ..| |. 
wvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgri.vvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamai

EKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCGGSLEVSLQSEL------DYEHWIT-RTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVK
..|   ..|. ...| .| ||.||||  .|.  . | . .    ..|        |. |   |. .   .  | . .||.. |||.|||.     .....
qekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle

NVREHirkkcvIKPVVVHCSAGVGRTGTYIALDRLTQHM-EDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
 || .        ||||||||||||.|| .|.  . . | .  .  |.  .| |.| .|.| .||| ||...|  |...|
avryd......tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 78-318 2.2e-46 152.8 In-house 49-282 (290) alignment 
Range on Protein: 78-318
Range on HMM: 49-282/290.0
TIAEMNK--TKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPreYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKR
 | . |   .|||.  .   . .||    ||   . ||. |||. | ...  .|  ||.| .|. |.|||. ..| . |||. . .| || ||.||.|..
kifdkntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

KGNSVTCGGSLEVSLQSELDYEHWITRTFMLRKNKMK--REVIQLQFTSWPDHGVPEQTKPMLDFVKNVREhirkkcVIKPVVVHCSAGVGRTGTYIALD
.|. .| |    .  ... . .. | .|. .|. .      .  |.  ||||. |.  |  .|  .. .|.      .  |||||||||.|||||..|..
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaie

RLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
   | . |   .|. ..|  .|  |   || ..||. . . |.|.
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0043147 (Phosphotyrosine protein) phosphatases II 109-312 3.2e-45 149.3 In-house 3-154 (172) alignment 
Range on Protein: 109-312
Range on HMM: 3-154/172.0
SETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTveggkdkchqywpkrkgnsvtcggslevslqseldyehwitrtfMLRK
. .|||||.|...   |...||.||||..|..| |||..|.. |.||..|.                                             .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

NKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVRE--HIRKKcviKPVVVHCSAGVGRTGTYIALDRLTQHMedndfvDVCGVVCEMRMHRNYLVQTET
 . .|..||.....|||||||  .. .|.|.. ..|  .....   .||.|||||||||||| .|.. . ...      ..  .|...|..|.. ||.. 
ellerlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnps

QYIFIH
||.|..
qyrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 76-320 2.2e-44 146.3 In-house 48-290 (305) alignment 
Range on Protein: 76-320
Range on HMM: 48-290/305.0
QATIAEMNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSP-REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPK
    |....||||.. .   ..| |||   .  | .||| |||.     | . .|..|||| .| ...| |. ..|   |||. .||| || || |||| 
anqsadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa

RKGNSVTCGGSLE---VSLQS--ELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHirkKcVikPVVVHCSAGVGRTGTY
 .|. ..  . .    ||     | | |  ||   .    . |  | .||.| ||| |||      |...  .|     | |  |.|||||||.||||| 
aqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs...k.v..pivvhcsagigrtgti

IALDRLTQHMEDND-FVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
.|.. . ... .|     .  .|  .| .| . .|.. ||.|||  ....| 
vaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_ptpA1_pd Subfamily ptpA1 82-271 2.5e-44 146.7 In-house 46-248 (418) alignment 
Range on Protein: 82-271
Range on HMM: 46-248/418.0
MNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGfNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKG----
 | .|||. .||| .|.||.|  .. |  .|||||||| |   |...|. |||||.|  |.|||.||..  ||||...  |  . || .|||.. |    
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

----NSVTCGGSLEVSLQSEL-DY-EHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVR---EHI-RKKCVIKPVVVHCSAGVGRTG
    |     |.  | |   . |     |||   |  .   |.. | |.  |||| .|..|.|. ......    ..|        |..|||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TYIA
|. .
tfct
0046846 (Phosphotyrosine protein) phosphatases II 111-316 9.6e-44 144.5 In-house 12-170 (176) alignment 
Range on Protein: 111-316
Range on HMM: 12-170/176.0
TDYINANYIPGFnsprEYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVtcggslevslqseldyehwitrtfmlrknk
 ||||||.| |      .||.|||||.|. | ..|..| . |..|..|. || |. ||..|||  .....                              
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

mkreviQLQFTSWPDHGVPEQtKPMLDFVKNVREHIRKKcviKPVVVHCSAGVGRTGTYIALDrltqHMEDNDFVDVCGVVCEMRMHRN-YLVQTETQYI
      | ... |||||||.  . .|.... .||.....   .||.||||||.|||||..|..     .| . ...|  .....|..|  . |||. || 
......qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIHDCLV
|..... 
flyefel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 53-318 2.1e-43 143.2 In-house 3-258 (267) alignment 
Range on Protein: 53-318
Range on HMM: 3-258/267.0
DSENGLMKEYDNIQAVGSIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKST
|.|  . ||...|. . ..       ||| |. .||... |||...|| |     ..| .|||| |. |..  . .|. |.||  |  | . .| ..| .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

IIVMMTQTvegGKDKCHQYWPKRKGNSVTC-GGSLEVSLQSELDYEHWITRTFMLrKNKMKREVIQLQFTSWpdhGVPEQTKPMLDFVKNVREHIRKKCV
.||..|..   ..|. ...|| . |..      ..| ||. | .  . ||  . . ||.  ..|    .  |    .  . || |  .  .  . . .  
vivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkw...nintnnkpylkplfgilaknqleng

IKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
 .|.||.||.||||.||.. .|   . .  .. .|.   . ..|  |  ||.|  .||.||. |...
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049772 (Phosphotyrosine protein) phosphatases II 81-318 6.8e-42 139.7 In-house 44-279 (314) alignment 
Range on Protein: 81-318
Range on HMM: 44-279/314.0
EMNKTKNRFNKILPYEhSRVKLMALKGKSeTDYINANYIPGFnspREYIACQGPLPETTNDM----------WRMI--WEKKSTIIVM------------
..|..|||. .|||.. .||.|  | ... .|||||.|. ||   . .||.||||..| .|           |||.  .. .. .|||            
flnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------MTQTVEGGkdkchqywpkrkgnsvtcggslevSLQSELDYEHWItrTFMLRKNKMKREVIQLQFTSWPDHGVPeQTKPMLDFVKNVREHir
          ..  ..|                        .. .. |.|..   . .  ... .|..|..  . .||...|  .. ...|.. ..|.  
LdaAlgKtpllildgng........................neptaadlellk..eelydpelferlgikylripvpDgsap.lledfdeflefieea..

kkCVIKPVVVHCSAGVGRTGTYIALDRLTQHMednDfVDVCGVVCEMRMHRN-----YLVQTETQYIFIHDCLVDF
     .||.|||.||.|||||..... |  ..   . |..  .. ..|. |       ....  ||.||...| ..
..dkggpvlvHCkaGkgRtgtfvvaaylmkll...g.vsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 81-318 1.5e-41 136.9 In-house 35-268 (281) alignment 
Range on Protein: 81-318
Range on HMM: 35-268/281.0
EMNKTKNRFNKILPYEHSRVKLMA-LKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGnS
 .|. |||. .|   . |||.|   .  |  |||| ||||      | ||  |||  ||  |.|||||....| |||. | .|  ..|| .|.|.     
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah.c

VTCGGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVRehirKKCviKPVVVHCSAGVGRTGTYIALDRLTQHM
.     | || .     .  .|  . |  .   | . .  .  |||  ||| .. ||  ....|     .    | |.||||||||.|| .|..   | .
clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir....ars..tppvihcsagvgrsgtlmaveialqsi

ED-NDFVDVCGVVCEMRM-HRNYLVQTETQYIFIHDCLVDF
     . |.  .|  .|.  |   |||  ||..|   |.||
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 56-316 4.2e-41 135.9 In-house 19-268 (288) alignment 
Range on Protein: 56-316
Range on HMM: 19-268/288.0
NGLMKEYDNIQAVGSIvRMDQATIAemNKTKNRFNKILPYEHSRVKLMalkgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
.|| ||| .    .|| .. .. ||  | |..|....   . .||||          ||.|| ..  . .|  | .| ||  | . .|.|. |.    ||
eglkkeyrdspneasi.diidsfia..nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyiv

MMTQTVEGGKDKCHQYWPKRKGNSVTCGGSLEVSLQSELDYEHWITRTFMLRKNKMKREV--IQLQFTSWPDHGVPEQTKPMLDFVKNVrehirkKCVIK
|... .| ||.|  .|.| ..|...  |    |  ..  | .. .. . .  ..... .|   .| .  |.|.||||. .. | ... .      | . |
mlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqk

PVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
|.|||.||||||||| |      . .  .||. .  .. ..| .|   .||| ||...| |. 
PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
0049260 (Phosphotyrosine protein) phosphatases II 118-313 7.4e-41 134.7 In-house 1-144 (152) alignment 
Range on Protein: 118-313
Range on HMM: 1-144/152.0
YIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWpkrkgnsvtcggslevslqseldyehwitrtfmlrknkmkreviQ
.|.|.. |.|.||.|||.|.|..| |||..| . |.|||.|. .| ||.||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

LQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKCviKPVVVHCSAGVGRTGTYIALDRLTqhmednDFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
 ... |||||||. .  .|.... .......|   .||.||||||||||||..|.. .         |..  .|  .|..|.. |... |..|...
ylhlpwpDhgvpdlsqlllflllfieklaldkg..gpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 78-320 4.2e-39 129.2 In-house 30-271 (285) alignment 
Range on Protein: 78-320
Range on HMM: 30-271/285.0
TIAEMNKTKNRFNKILPYEHSRVKLmalKgKSETDYINANYI--PGFNSpREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKR
|  | |   ||.  .   | .|| |   | . . ||| |...  || .    ||. ||||||| .|.|.||...| . ..|.   .||| .||  |.|..
tayeanpdlnryadvrcieetrvvl...k.nhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

KGNSVTCGgSLEVSLQSEL----DYEHWITRTFMlRKNKMKREV---IQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKcviKPVVVHCSAGVGRTGT
 |. |  |   |..|            . . | .   .    |     ..|   |||.  ||...||... | |..   |.   ||..|||||||||| |
lgevvkfg.kyeitlteckeeaiagtilnaltvi.ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke...kpicvhcsagvgrtat

YIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
.. .|  | .. .|  ...  .| |||  |   ||.  |..|..  |...| 
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 76-239 5.1e-39 128.9 In-house 24-190 (297) alignment 
Range on Protein: 76-239
Range on HMM: 24-190/297.0
QATIAEMNKT--KNRFNKILPYEHSRVKLmaLKGKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQY
. . |  | .  |||...|| .. .||||  |.. .|.|||||.|.  |  ...  ||  |||| .| .| |....|.   .|||...  |.|.|||  |
sfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapy

WPKRKGNSVTCGGSL-EVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFV
||. ...  ..|  . |   .   .... |   . |   . .| |   || |||||||| . . .  | 
wpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 55-320 6.7e-39 128.4 In-house 21-288 (305) alignment 
Range on Protein: 55-320
Range on HMM: 21-288/305.0
ENGLMKEYDNIQAVGSIVRMDQATIAeMNKTKNRFNKILPYEHSRVKLmalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTII
 .|| .|. ... .  . .|     |  .. |||.  .   .. ||||   .|    .|| |||.     |. .| .| || .|  |.| | ...|   |
paglraefvamkrfndfekmkafkea.qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveai

VMMTQTVEGGKDKCHQYWPKRKGNSVT-----------CGGSLEVSLQSELdyEHWITRTFML--RKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKN
 |. . .| |  ||..|.. .... ..           .  | .......   .  .|.| ..     . .| | .  .  ||| |||     .|.....
fmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkda..kakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek

VREHirkKcviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFV-DVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
 |     |    |.|||||||.||||. . |. . . .   . . |   ..  .|  ||  .||..||.|.|. ....|.
arps...k...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0044763 (Phosphotyrosine protein) phosphatases II 94-315 1.3e-37 124.5 In-house 1-167 (178) alignment 
Range on Protein: 94-315
Range on HMM: 1-167/178.0
PYEHSRVKLMALKGKSETDYINANYIPGFnsprEYIACQGPlpettNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGnsvtcggslevslqse
|....||.|. | |   .|||||..| ..     |.....|      | .....| . | ||..|...|.|. ||..|||.. |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

ldyehwitrtfmlrknkmkrevIQLQFTSWPDHGVPEQTKPMLDFVKNVREHI-RKKcviKPVVVHCSAGVGRTGTYIALDRLTQHmedndFVDVCGVVC
                      || ... .||||||. .. .|.||. ..|.. .|.   .||.|||||||||.|| .|.. . ..      ...  .. 
......................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

EMRMHRNyLVQTETQYIFIHDCL
..|..|.  |... |. ..... 
lvrerRp.ivpnpgqlrqLyefe
0051082 (Phosphotyrosine protein) phosphatases II 111-315 9.1e-37 121.3 In-house 3-149 (151) alignment 
Range on Protein: 111-315
Range on HMM: 3-149/151.0
TDYINANYIPGFnspreYIACQGPLPettnDMWRMIWEKKSTIIVMMTQTVEGGkdKCHQYWPKRKgnsvtcggslevslqseldyehwitrtfmlrknk
.||||..|. |.     .....|||.    | .....| . . ||......| |  .|..|.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

mkREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREhirkkcV-IKPVVVHCSAGVGRTGTYIALDRLTQHmedndfVDVCGVVCEMRMHRNYLVQTETQYI
  .||.......|||.|.|. .. .|.|.. ...         .||.||||||.||||| .||... ..      |..  .. |.|..| ..||...|..
..ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FIHDCL
|.. .|
fqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 78-310 7.5e-36 118.4 In-house 45-272 (301) alignment 
Range on Protein: 78-310
Range on HMM: 45-272/301.0
TIAEMNKTKNRFNKIlPY-EHSRVKLMAlKGKSEtdYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRK
. | ..| |.|.... |   .. |.... .||     | ||.||    |. .|| ||||..|..|.| |.   .   |||..|.||  ..||..| | . 
syaylpkdkhryptv.PckPstaveviv.dGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

GNSVTCGG-SLEVSLQSELDYEHWITRTFMLRKNK---MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHirkkcvIKPVVVHCSAGVGRTGTYIAL
....  |  ....  .  .  .. . ||. ..        | |.  |...|.|.|||.    . |... |..        ||.|||||||.||. ..|. 
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks......ekPivvhcsaGiGrsvafigt

DRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
. |....| .  ...   . ..| ||   |||..|  .
eylareveadptieltealkhlrehrwngvqtnsqlyw
PTPc_DSPc_SM00012 215-316 4.5e-35 115.4 In-house 2-104 (105) alignment 
Range on Protein: 215-316
Range on HMM: 2-104/105.0
VIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
| ....|.||||||||.....|.....|... .|.   ||||||||||||||||..||| | |..|.. ..||.. .|.|.|..|. .||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLV
.| 
all
subfamily_CG42327_pd Subfamily CG42327 59-247 3.7e-34 112.8 In-house 8-195 (319) alignment 
Range on Protein: 59-247
Range on HMM: 8-195/319.0
MKEYDNIQavGSIVRMDqaTIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFN-SPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
..|....     | | |   .    | |.|. ...|  ..|| |     . .. |..|.|. |.. .|  |||.| .| ... |.||..||..| .|| .
aeefrdlP..qliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivql

TQTVEGGKDKCHQYWPKRKG-NSVTCGGSLEVSLQSELDYEHWITRTFMLRK--NKMKREVIQLQFtSWPDHGVPEQTKPMLDFVKNVREHIR
|.  | | ..| .|.| ... ..    | . |.|.     ..... |..|..  ... ||.    .  |.. .|| . ....  . .||. ..
tdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 56-319 3.4e-32 106.2 In-house 27-290 (310) alignment 
Range on Protein: 56-319
Range on HMM: 27-290/310.0
NGLMKEYDNIQAVGSIVRMDQATIAEMnkTKNRFNKILPYEHSRVKLMALKGKSEtDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIV
.||.|.| ...|        .|   .|   |||.  ..  . |||||   | . | ||| |||.        .| .||||  |  |.||||.....  |.
eglvkqyrkldakqdssltyeaykkym..hknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MMTQTVEGGKDKCHQYWPKRkGNSVTCgGSLEVSLQSELDYEHWI---TRTFMLRK--------NKMKREVIQLQFTSWPDHGVPEQTkpmldfVKNVRE
.. ...| |. ||  |||   | . |  | . |.  ||   |  |   . ||.  .        |  .  |  ...  ||| |||..       .. | .
llckvgeegrpkcvgywpsl.gvtety.gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpq

HIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
 .  .    |.|||||||..|... .||.   ....  . ||.  |. |.. .|   .||| ||..|.   . | 
rllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa
subfamily_egg_pd Subfamily egg 77-323 4.2e-32 106.0 In-house 34-273 (307) alignment 
Range on Protein: 77-323
Range on HMM: 34-273/307.0
ATIAEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGgkDKCHQYWPKRK
 .... |..| | ...   . |||||   .|.   |.| ||.. |     |.| .| || .| .|.|||.....   |||.| ..|   ..|. |||| .
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

GNSVTC-GGSLEVS---LQSELDYEHWITRTFMLRKNkmkREVIQLQFTSWPDHGVPEQTKPMldfvkNVREHIRKkcVIKPVVVHCSAGVGRTGTYIAL
 .|.    |||..    ..|. |    .|.  ..  .   .|   |.   .  . . .   |.     .|  ..|.  . |||||..  || ...| .|.
sdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdvnnssdvyspl.....rvlrklrn..lskpvvvqdilGvskaatlvai

DRLTQHMEDNDF--VDVCGVVCEMRMHRNYLVQTETQYIFIHDcLVDFFHSDV
.    ..         |   |  .|..|.. |..  .|.|..  || ||  ||
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyr.lvlfffrdv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 58-321 7.1e-30 98.8 In-house 21-278 (312) alignment 
Range on Protein: 58-321
Range on HMM: 21-278/312.0
LMKEYdniQAVGSIVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMalkGkSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMM
| |||   .||| ||   . |     |  ||. .|  ..  |  |    |  |  || ||..     |  ....|||| .|.  .|..     || |...
ltkey...kavgnivsdsectaflkfkdlnrypniqcwdrgrftla...g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiill

TQTVEGGKDKCHQYWPKRKGN------SVT--CGGSLEVSLQSELDYEHWITRTfMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHirKk
.  || | .|| .|     |        |       .|.  .|     | . .  ...    .  . . |..||||||.|.     | ..  |.    | 
cgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkv.vvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd..k.

cviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFHS
   |||. ||||||||||| . .. .   .      .|  .   .|  |   |..  ||..   |...|..|
...kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
0048076 (Phosphotyrosine protein) phosphatases II 171-316 2.6e-27 90.7 In-house 2-140 (145) alignment 
Range on Protein: 171-316
Range on HMM: 2-140/145.0
YWPKRKGNSVTCGGSLeVSLQSELDYEH--WITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKcviKPVVVHCSAGVGRTGT
||| .  ...  |.   . |. ||  ..  .   ...  ..  .|..||.....|||||||. .. .|.|.. ..|.....   .||.||||||||||||
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgt

YIALDRLTQhmedNDfVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
..|.. . .    .. |..  .. ..|..| . |... |..|..... 
lvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 83-180 3.1e-27 90.2 In-house 47-158 (350) alignment 
Range on Protein: 83-180
Range on HMM: 47-158/350.0
NKTKNRFNKILPYEHSRVKLM-AL-------KGKSETDYINANYIP------GFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKC
  .|||.. |||||||||||  .|       .  |  |||||||.         |.   ||| |.|||.| .|....| . | ..|...|. || . .||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HQYWPKRKGNSV
..||.. . . .
yrYWqegsyddi
0048179 (Phosphotyrosine protein) phosphatases II 190-313 3.6e-26 87.0 In-house 24-139 (144) alignment 
Range on Protein: 190-313
Range on HMM: 24-139/144.0
LQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKKcviKPVVVHCSAGVGRTGTYIALDRLTqhmeDNDfVDVCG
|  .|.  ..|. |    .. ..||.||.....|||||||. .. .|.|.. ..|.....   .||.||||||||||||..|....      .. ...  
llkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtgtlvaaylmk....klg.lslee

VVCEMRMHRNYLVQTETQYIFIHD
.. ..|..| . |... |..|...
alalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 134-315 2.2e-25 83.8 In-house 99-284 (302) alignment 
Range on Protein: 134-315
Range on HMM: 99-284/302.0
PLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCGG------SLEVSLQSELDYEHWITRTFMLRKN----KMKREVIQLQFTSW
|  .|..  | .| . . .|.| ... ||... || .|. .. |. .. |       |..  |.   | ..    |  .. .    |.|. |  |.|..|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPEQTKPMLDFVKNVREHirKkcviKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
|||| |..... || .|    .  |    | |.|||||||||||| .|.    |    ..  |.  .|. .|  |   ||.|.| |..  |.
pdhGapkeaytaldilkfcesy..k....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 125-312 2.5e-23 77.3 In-house 4-197 (199) alignment 
Range on Protein: 125-312
Range on HMM: 4-197/199.0
PREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSvTCGGSLEVSLQSELDYEHWITRTFMLRKNK----MKREVIQLQF
 | |||.| || ||  |.|.|.||  |  |||. .     .     |||  .  . .  ||| |. ..      .   ...| .|       ||. . ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPEQTKpMLDFVKNVREHIRKKCVIK--PVVVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
||| ..  |. .  .. ||   ||  .|    |  ||.|||| | | || ..|||   . | |     ||.  |   .|  |  .. .  .| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 126-312 2.6e-23 77.2 In-house 4-196 (198) alignment 
Range on Protein: 126-312
Range on HMM: 4-196/198.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSvTCGGSLEVSLQSELDYEHWITRTFMLRKNK----MKREVIQLQFT
| |||.| || ||  |.|.|.||  |  |||. .     .     |||  .  . .  ||| |. ..      .   ...| .|       ||. . |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPEQTKpMLDFVKNVREHIRKKCVIK--PVVVHCSAGVGRTGTYIALDRLTQ-HMED-NDFVDVCGVVCEMRMHRNYLVQTETQYIFIH
|| ..  |. .  .. ||   ||  .|    |  ||.|||| | | || ..|||   . | |     ||.  |   .|  |  .. .  .| ||.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 85-313 1e-21 72.4 In-house 21-253 (290) alignment 
Range on Protein: 85-313
Range on HMM: 21-253/290.0
TKNRFNKILpYEHSRVKLMALKGKSETDYINANYIPgFNSPREYIACQGPLPET-------TNDMWRMIWEKKSTIIVMMTQTVEGGKD----KCHQYWP
 ..| .  |  |..|| |   . .   ||| ||..  . .  . |. | |. ..        .. | |. . |.. .||. .  |  ..     | .| |
mdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

KRKGNSVTCGGsLEVSLQSELDYEHWITRTFMLRKNKMKR-EVIQLQFTSWPDHGVPEQTKPMLDFVKNVrehirkKCVIKPVVVHCSAGVGRTGTYIAL
.. |.... .| |.|. .|    .  .||. ... .. .   |   .. .| .  |.|.|| .|. ...|      |.   ||.|||  |. |  .  |.
esvgeelkfkg.ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkv......kasktpvivHcvdGiSrsAalaai

DRLTQHME-DNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHD
.   | .   .. | .  |. ..| .|. ........ |.  
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 211-317 2e-21 70.8 In-house 87-192 (440) alignment 
Range on Protein: 211-317
Range on HMM: 87-192/440.0
MKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHiRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIF
  | . | .. .|||.|||. . |.| ....| |  ..|.   |..||||||.||||  ||.| . .. . .| .|.  ..  ||  |  .|||  || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHDCLVD
.|.....
vheavle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 83-179 2.7e-19 63.7 In-house 48-160 (349) alignment 
Range on Protein: 83-179
Range on HMM: 48-160/349.0
NKTKNRFNKILPYEHSRVKLMA-LK-------------GKSETDYINANYI--PGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKD
  .|||...|||||||||||   ||             .    |||||||.  . ..  . ||| | ||| | .| ...|  ..  ... ...  | . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHQYWPKRKGNS
||..|| . . ..
kcdiywqelsysn
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 82-316 3.5e-19 63.5 In-house 46-276 (303) alignment 
Range on Protein: 82-316
Range on HMM: 46-276/303.0
MNKTKNRFNKILPYEHSRVKLmalkgkSETDYINANYIpGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVT
 |  ||||  ..  .||.|||      |.. || |.|.  ..| .  |  | ||. |. |.|.|| |.|   ....    |  |   .  .|. .     
knmdknrfvdvicldhskvkl......sdssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

CGGSLEVSLQSELD-YEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKP-MLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIALD--RLTQ
   |. |    ...  . |  .   . . . |  .   .. .||   .| .. | ..  . ...  .|| .  .| |    .|.||.||.  ..   |. 
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

HMEDNdFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLV
| |..  .|.  ..  .|  | . ||  .|. ...  | 
hseqa.sldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_eak_pd Subfamily eak 46-319 1.2e-18 61.6 In-house 19-305 (332) alignment 
Range on Protein: 46-319
Range on HMM: 19-305/332.0
HYDWLKADSENGLMKEYDNIQAVGSIVRMdQAtIAemNKTKNrFNKILPYEHSRVKLMALKgKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRM
 . | . .    .....|. | . ||    .  .   .  .|   ||.||..  |.| . . . .  ||||  .   .  |.||    .  .    .|.|
nhiwnrinqrinivadlddyqrllsiset.ar.le..avnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqm

IWEKKSTIIVMMTQTVEGGKDKCHQYWPKRkGNSVTCGGSLEVSLQSELDYEHWITRTFMLRKNKMKREVIQLQFTSWPDHGVPEQTKpMLDFVKN----
. |.||  ||.. . || . .|  .|.|.. .  .   | |.|  .. .  .   || ..|.|     .|   ..  | .  .|     .| . |     
vleqkspaivqlledvelkleksdkyfpdk.treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyed.flalrkvmkev

------------VREHIRKKCVIKP---VVVHCSAGVGRTGTYIALDRLTQHMED--NDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
            ..  ..|     |    .. .. |  |.|... .| | . ...  ..   |  ..  .. .|.. | .. |. ||.. ..|..
GvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 138-320 2.7e-17 57.7 In-house 40-222 (255) alignment 
Range on Protein: 138-320
Range on HMM: 40-222/255.0
TTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCGgSLEVSLQSelDYEHWITRTF----MLRKNKMKREVIQLQFTSWPDHGVPEQTK
| . ....|  .|.. .||..   | |..||..|.|  | .       ..|.        . . ||     .| . |  ..|   ... |...  ||...
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PMLDFVKNVREhirkkCviKPVVVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
 .|  .| ||.        |.||||||.|.||. ...  . . |     ..  . |  |   .. |.| .|.  ..|  |  |    ..|...
eilnilkvvrd.....s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 214-320 5.3e-16 53.3 In-house 216-345 (350) alignment 
Range on Protein: 214-320
Range on HMM: 216-345/350.0
EVIQLQFTSWPDHGV---PEQTKPMLDfV------KNVREHIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQ-----HMEDNDFV---------D-VCG
.| |||.  |.| ..   ||.  ..|. |      ... |   ..   .|..||||||||||||...|| | .     ..  ....         | .  
vvyqlqvknWkDlslllnPesilqale.vkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

VVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
.| |.|  |  .||. .|.|||...|  .| 
ivnelrkqrismvqnldqfifiYeallfyfa
subfamily_hpo-7_pd Subfamily hpo-7 137-320 1.4e-15 51.9 In-house 45-228 (263) alignment 
Range on Protein: 137-320
Range on HMM: 45-228/263.0
ETTNDMWRMIWEKKSTIIVMMTQTVEGGKDKCHQYWPKRKGNSVTCGgSLEVSLQSELDyeHWITRTFML----RKNKMKREVIQLQFTSWPDHGVPEQT
.| . ....|  .|.. .||..   | |..|| .|.|  | .       ..|.     .    . .|  |     . |  ..| . ... |...  ||..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

KPMLDFVKNVREhirkkCviKPVVVHCSAGVGRTGTYIALDRLTQ----HMEDNDFV--DVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFFH
. .|  .| .|.        |..|||||.|.||.  .   . . |     ..  . |  |   .. |.| .|.  ..|  |  |    ..||. 
reilnilkvarn.....s..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 256-317 4.7e-15 49.7 In-house 2-63 (69) alignment 
Range on Protein: 256-317
Range on HMM: 2-63/69.0
VVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD
|||||.| |||||.||.      .  . .||.   |  ||  |  .|  | .|||||| ||.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_CG42327_pd Subfamily CG42327 253-318 1.7e-14 48.3 In-house 248-314 (319) alignment 
Range on Protein: 253-318
Range on HMM: 248-314/319.0
KPVVVHCSAGVGRTGTYIALDRLTQHMEDN-DFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
 |.||||| ||||||. || |   ...|..   ||.  .|  .|  |   |.|  || ||.  |  .
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 256-317 3.5e-14 46.9 In-house 1-62 (69) alignment 
Range on Protein: 256-317
Range on HMM: 1-62/69.0
VVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVD
|||||.| |||||.||.      .  . .||.   |  ||  |  .|  | .|.|||| ||.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 63-174 1.7e-13 44.8 In-house 72-180 (244) alignment 
Range on Protein: 63-174
Range on HMM: 72-180/244.0
DNIQAVGSIVRMDQATIA----EMNKTKNRFNKILPYEHSRVKLMalKGKSETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMT
. ||.  .|.| | . .       |  |||    ||.. .|| |   ||     |||| ..  .    |||  | || .|. |.|.|. |..  ..|.. 
nyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg

QtVEggkdKCHQYWPK
  ||    .  .||| 
s.ve....eedeywpd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 213-320 5.9e-12 39.6 In-house 218-345 (349) alignment 
Range on Protein: 213-320
Range on HMM: 218-345/349.0
REVIQLQFTSWPDHGVPEQTKPMLDFVKnVREHIR---------KKCVIKPVVVHCSAGVGRTGTYIALDRLTQ--HMEDNDFVDV----------CGVV
 |..|||.  |.| ..    . .|  .. |....          ..    ...|||||| ||||... || | .  ..  |... .            .|
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

CEMRMHRNYLVQTETQYIFIHDCLVDFFH
 |.|  |  .||  .|.|.|...|. .| 
nelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 37-133 7.2e-11 36.1 In-house 4-95 (95) alignment 
Range on Protein: 37-133
Range on HMM: 4-95/95.0
PILLTDIDTHYDWLKADSENGLMKEYDNIQAVGSIVrmDQATIAEMNKTKNRFNKILPYEHSRVklmALKGKSETDYINANYIPGFNSPREYIACQG
|| .. . .|   ....|.. . .|.  |.          .  .| |  |||| .|.||. .||   .|  | ..||||| .. |.     |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgap..ytvgsseanipknrflnifpydatrv...vlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 65-124 1.2e-10 35.3 In-house 30-88 (440) alignment 
Range on Protein: 65-124
Range on HMM: 30-88/440.0
IQAVGSIVRMDQATIaEMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINANYIPGFNS
.   |     |.|..   || |||. .|| |.|||| |  .||  ..||||| || | .|
llpsglsqpsdiasl.pnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 254-315 1.7e-10 35.3 In-house 230-291 (297) alignment 
Range on Protein: 254-315
Range on HMM: 230-291/297.0
PVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCL
...|||||||||.|  .  | . . .  .   ||  ..  .|  |  ||||  |. ...|  
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 220-323 2.2e-10 34.4 In-house 188-289 (302) alignment 
Range on Protein: 220-323
Range on HMM: 188-289/302.0
FTSWPDHGVPEQTKPMLDFVKNVreHIRKKCVIKPVVVHCSAGVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDFF
.| |... ||..   .   ...|  . .|  . ...|.    |.|| |. ..|    ....... . .  .|  .|  |   |.. .||.... .|. ..
ltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

HSDV
   |
kkkv
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 79-176 2.9e-10 33.3 In-house 21-88 (169) alignment 
Range on Protein: 79-176
Range on HMM: 21-88/169.0
IA--EMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtqtveGGKDKCHQYWPKRK
.|    |.||||    |   | ||||  .  .  .|||||                           |||||  ...||..     |. |   ..||...
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwpeke
0038934 (Phosphotyrosine protein) phosphatases II 206-272 3.7e-10 35.3 In-house 70-135 (194) alignment 
Range on Protein: 206-272
Range on HMM: 70-135/194.0
LRKNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVREHIRKkCVIKPVVVHCSAGVGRTGTYIAL
  ......  |.     .||.|.. ... .|.|.. | |.... .  . |.||| ||.||||| .| 
YdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaa
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 83-167 3.8e-10 33.7 In-house 34-117 (332) alignment 
Range on Protein: 83-167
Range on HMM: 34-117/332.0
NKTKNRFNKILPYEHSRVKLMALKGKSetDYINANYIPGFNSPREYIACQGPLPETTND-MWRMIWEKKSTIIVMMTQTVEGGKDK
|   ||  ..  ..||||.|    ||   |. ||... |..    || .| |. . |.  .|||. |.| ..|... .  |  | |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 80-176 4.2e-10 32.7 In-house 21-87 (169) alignment 
Range on Protein: 80-176
Range on HMM: 21-87/169.0
A--EMNKTKNRFNKILPYEHSRVKLMALKGKSETDYINAnyipgfnspreyiacqgplpettndmwRMIWEKKSTIIVMMtqtveGGKDKCHQYWPKRK
|    |.||||    |   | ||||  .  .  .|||||                           |||||  ...||..     |. |   ..||...
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpeke
subfamily_PTPDC1_pd Subfamily PTPDC1 205-313 8.5e-10 33.4 In-house 72-170 (182) alignment 
Range on Protein: 205-313
Range on HMM: 72-170/182.0
MLRKNKMKREVIQLQFTSWPDHGVPEQTKpMLDFVKNVREHIRKKcvikPVVVHCSAGVGRTGTYIALDRLTQHMedndfVDVCGVVCEMRMHRNYLVQT
   ....... |     .|.|.||.  .. .|| || |   ....     | ||| || ||||  ||   . ..      ..    .  .| .|   .||
sYdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg....kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqt

ETQYIFIHD
 .|  ....
reqvelvke
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 93-227 1.1e-09 32.6 In-house 3-125 (130) alignment 
Range on Protein: 93-227
Range on HMM: 3-125/130.0
LPYEHSRVKlmalkgksETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQtVEggkdKCHQYWPKRKGNSVtCGGSLEVSLQS
|..| ||..        . .||||...   .  .||.  | || .|. |.|.|. |.   ..|..   ||    .  .|||  .         . |.|  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.ve....eedeywpdsePlew.yeediivtltd

ElDYEHWITRTFMLRKNKMKR---EVIQLQFTSWPDHG
  |  . |  ...  ......    .  .| . ||  |
r.defknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 84-158 1.3e-09 32.1 In-house 38-117 (347) alignment 
Range on Protein: 84-158
Range on HMM: 38-117/347.0
KTKNRFNKILPYEHSRVKLMALKGKS-----ETDYINANYIPGFNSPREYIACQGPLPETTNDMWRMIWEKKSTIIVMMT
 .||| ..    . .|| |   | |         |||| .|   |. .|||  | |||.|  |.|.|.   | | .| . 
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
PTEN_1 212-296 3.2e-09 31.9 In-house 92-172 (196) alignment 
Range on Protein: 212-296
Range on HMM: 92-172/196.0
KREVIQLQFtSWPDHGVPEQTKpMLDFVKNVREHIRKKCVIKPVVVHCSAGVGRTGTYIAlDRLTQHMEdNDFVDVCGVVCEMRM
|. |..|.| ...|||.|   . ..|..|.. | ....   . |.||| ||.||.|| .|   | ...   .. . .  |.|.|.
ksgveylhf.pieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk.ltadeAlelvrekRp
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 54-178 1.6e-07 25.1 In-house 24-144 (302) alignment 
Range on Protein: 54-178
Range on HMM: 24-144/302.0
SENGLMKEYDNIQAVGsiVRMDQATIAEMNKTKNRFNKILPYEHSRVKLMAlkgkSETDYINANY--IPGFNspREYIACQGPLPETT---NDMWRMIWE
 .  . ||...|...   | ... ..   |  ||. ...  ... .||| |    .. .|.||    .| ..  |. |  | |  ...   .. |||...
dtaevkkefkkidtmk..vdlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfq

KKSTIIVMMTQTVEGGKdKCHQYWPKRKGN
.| . .|.. .. |  |   ....||. |.
ekivsvvilvgeeelkk.tlselfpkksgd
subfamily_PTEN_pd Subfamily PTEN 209-308 4.3e-07 25.1 In-house 76-169 (184) alignment 
Range on Protein: 209-308
Range on HMM: 76-169/184.0
NKMKREVIQLQFTswpDHGVPeQTKPMLDFVKNVREHIRKKCvIKPVVVHCSAGVGRTGTYIALDrLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQY
.|.. .|....|.   ||  | . . . ..|....... ..   . ||||| || ||||. |.   | ...  ..  ..  .  |.|.. .  |.   | 
kkfdgrvavypfd...Dhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPsqr
subfamily_VSP_pd Subfamily VSP 224-271 9.4e-07 23.0 In-house 102-147 (212) alignment 
Range on Protein: 224-271
Range on HMM: 102-147/212.0
PDHGVPEQtKPMLDFVKNVREHIRKKcVIKPVVVHCSAGVGRTGTYIA
 || ||.  . .| | |.|.|.. |    . ...||  | ||||| . 
ddhnvpkl.eellvftkevkewlekd.lknvlaihckGGkgrtGtivc
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 126-183 2.1e-06 21.4 In-house 236-289 (440) alignment 
Range on Protein: 126-183
Range on HMM: 236-289/440.0
REYIACQGPLPETTNDMWRMIWEKKSTIIVMMTQTVEggkDKCHQYWPKRkGNSVTCG
  .|| | ||  |  |.||.. . . . |.|. |  .     |  |||     ||| |
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvn.trsvtfg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 167-318 2.5e-06 21.2 In-house 149-301 (332) alignment 
Range on Protein: 167-318
Range on HMM: 149-301/332.0
KCHQYWPKRKGNSVTCGgsleVSLQSELDYEHWITRTFML--RKNKMKREVIQLQFTSWPDHG-VPEQTKPMLDFVK--NVREHIRKKCVIKPVVVHCSA
 |...||... .         .|.|.  |.     .|| |   ..|  .. . ..|  | |   .||    |   .|   .|   .   .| |... |..
icrkfwpekrskkdfpa....lsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GVGRTGTYIALDRLTQHMEDNDFVDVCGVVCEMRMHRNYLVQTETQYIFIHDCLVDF
|| .   . ..| .  .. ..  | .   .  ..|.|   ..|   |    . |. |
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf
PTPc_motif_SM00404 189-271 7e-06 21.0 In-house 21-99 (140) alignment 
Range on Protein: 189-271
Range on HMM: 21-99/140.0
SLQSELDYEHWITRTFMLR--KNKMKREVIQLQFTSWPDHGVPEQTKPMLDFVKNVrehirkKCVIKPVVVHCSAGVGRTGTYIA
 |...|. .| |  |   .  |.. .....|..        . .. . .|||..|.      .   . |.||| ||| |..| |.
allkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatlii