Gene PTPRB-4 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP070_AA protein Get Run
SpurP070_AA_80-187 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 83-188 2.1e-46 153.3 In-house 29-135 (293) alignment 
Range on Protein: 83-188
Range on HMM: 29-135/293.0
LKAEKIKAM-MDLIMKCDQHEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQL
 . |..||. .|  .|....... | ..  ...  .|||||||||.|.|..|||||||||||||||||.|.|||||.||||.|||.||||.|||||||||
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltql

VEKGKVR
||||||.
vekgkvk
subfamily_PTPRD_pd Subfamily PTPRD 113-187 9.6e-34 111.9 In-house 57-131 (564) alignment 
Range on Protein: 113-187
Range on HMM: 57-131/564.0
VILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
..  .||||.| ..  |...|||||..| ||.......| ||||. |..| |||.||...|.|||||.|.|||||
ivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkv
0051299 (Phosphotyrosine protein) phosphatases II 106-186 6.3e-32 106.6 In-house 51-131 (288) alignment 
Range on Protein: 106-186
Range on HMM: 51-131/288.0
AAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
       .. ..||||||  | .....|||||.||.|||..|.|.|.|||||.||.| |||.||.....|||||.|||.|.
eknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgr
0047943 (Phosphotyrosine protein) phosphatases II 95-187 2.6e-31 104.5 In-house 29-117 (273) alignment 
Range on Protein: 95-187
Range on HMM: 29-117/273.0
IMKCDQHEEKPAAQCTGKVILNEHSRVKLaalaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
 ... ...|         .. ..||||||    .|...|||||.|..|||..|.|.|.|||||.||.| |||.||.....|||||.|||.|..
tysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgre
0036941 (Phosphotyrosine protein) phosphatases II 96-186 2.8e-31 104.4 In-house 31-117 (297) alignment 
Range on Protein: 96-186
Range on HMM: 31-117/297.0
MKCDQHEEKPAAQCTGKVILNEHSRVKLaalaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
... . .|    .    .. ..|.||||    ||...|||||.|..||. .|.|.|.|||||.||.| |||.|| ....|||||.|||.|.
lsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr
0050432 (Phosphotyrosine protein) phosphatases II 97-186 3.1e-31 104.3 In-house 61-147 (308) alignment 
Range on Protein: 97-186
Range on HMM: 61-147/308.0
KCDQHEEKPAAQCTGKVILNEHSRVKLaaladDSDTDYINANYIPGY--NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
.. ...|         .. ..||||||     |...|||||.|..||  ..||.| |.|||||.||.| |||.|| ....|||||.|||.|.
svallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengr
subfamily_PTPRG_pd Subfamily PTPRG 93-186 3.5e-31 103.0 In-house 36-130 (563) alignment 
Range on Protein: 93-186
Range on HMM: 36-130/563.0
DLIMKCDQHEEKPAAQCTGKVILNEHSRVKLAALADDSDT-DYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
|| ..  |..|      . ...  ..|||||. |..  .. |||||||| ||.  ..|.| ||||. |.|| ||||||....||||.|.|||.|.
dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 113-187 6.2e-31 102.6 In-house 55-129 (318) alignment 
Range on Protein: 113-187
Range on HMM: 55-129/318.0
VILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
..  .|.||||  |... ..||||||||.||.. ....|.|.||| |..|.|||.||.....||||||..|.||.
ilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergka
0040438 (Phosphotyrosine protein) phosphatases II 93-186 8.9e-31 102.7 In-house 32-125 (317) alignment 
Range on Protein: 93-186
Range on HMM: 32-125/317.0
DLIMKCDQHEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
   ... ...| .       .....||||||  |  | |.|||||.|..|.| .|.| |.|||||.||.| |||.|| ....|||||.|.|.|.
ldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgr
0046845 (Phosphotyrosine protein) phosphatases II 111-187 2e-30 101.6 In-house 35-117 (284) alignment 
Range on Protein: 111-187
Range on HMM: 35-117/284.0
GKVILNEHSRVKLAALADD-SDTDYINANYIPGY-----NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
  .. ..||||||  | .| .|.|||||.|..||     .....|.|.|||||.||.| |||.||.....|||||.|||.|..
kdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre
0043336 (Phosphotyrosine protein) phosphatases II 85-186 9.1e-30 99.5 In-house 26-127 (278) alignment 
Range on Protein: 85-186
Range on HMM: 26-127/278.0
AEKIKAMMDLIMKCDQHEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEK
 |..  .    ... ...|      .  .....||||||  |  | |.|||||.|..||| ||.| |.|||||.||.| |||.|| ....|||||.|||.
feellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvel

GK
|.
gr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 95-188 1.2e-29 98.4 In-house 40-132 (319) alignment 
Range on Protein: 95-188
Range on HMM: 40-132/319.0
IMKCDQHEEKPAAQCtGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKVR
. .....| |.  .    ..  ...||.|..| .  ..|||||..| ||.  ..|.| |.||  |..|.|||.||...||.||||.||||.||.
fdsaskeenkkknry.qnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvk
0045450 (Phosphotyrosine protein) phosphatases II 94-186 2.6e-29 98.4 In-house 45-146 (307) alignment 
Range on Protein: 94-186
Range on HMM: 45-146/307.0
LIMKCDQHEEKPAAQCTGKVILNEHSRVKLAALADD-SDTDYINANYI--------PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEK
  ... ...|         .....|.||||  | .. .|.|||||.|.        .||...|.|.|.|||||.||.| |||.||.....|||||.|||.
geysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvel

GK
|.
gr
0039614 (Phosphotyrosine protein) phosphatases II 96-186 5.5e-29 97.0 In-house 48-140 (297) alignment 
Range on Protein: 96-186
Range on HMM: 48-140/297.0
MKCDQHEEKPAAQCTGKVILNEHSRVKLAALAD-DSDTDYINANYIPGYNS-PREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
... ...|         .. ..||||||  . . | |.|||||.|..||.  .|.| |.|||||.||.| |||.|| ....|||||.|||.|.
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr
DSPc_SM00195 106-186 1e-28 95.8 In-house 28-108 (263) alignment 
Range on Protein: 106-186
Range on HMM: 28-108/263.0
AAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
. .   ......|.||||    .....|||||||| |.|..... |.||||| ||.| |||.||.|..||||||. .|.||
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk
PTPc_SM00194 106-186 1e-28 95.8 In-house 28-108 (263) alignment 
Range on Protein: 106-186
Range on HMM: 28-108/263.0
AAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
. .   ......|.||||    .....|||||||| |.|..... |.||||| ||.| |||.||.|..||||||. .|.||
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 113-188 2.8e-28 93.8 In-house 50-125 (281) alignment 
Range on Protein: 113-188
Range on HMM: 50-125/281.0
VILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKVR
..  ...|||..   ....|||||||..|||....|..|.|||.| .....|.|.||.| |.|||.|. .|.||..
ivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklk
subfamily_PTPRA_pd Subfamily PTPRA 83-186 1.9e-27 91.0 In-house 41-140 (330) alignment 
Range on Protein: 83-186
Range on HMM: 41-140/330.0
LKAEKIKAMMDLIMKCDQHEEkpaaQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLV
| | .|.| ..|  | . .|     .   ... ...||| |. .    ..||||| .| ||.   .|.|.|||.  ||.|.||||||.|.. |||||.| 
lPagpiqatlelaskeenkek....nrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelk

EKGK
|. .
erke
subfamily_PTPN9_pd Subfamily PTPN9 112-187 1.9e-27 91.1 In-house 50-125 (297) alignment 
Range on Protein: 112-187
Range on HMM: 50-125/297.0
KVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
 |.  ...||.|| . .|. .||||||.. ||. .. |.| ||||. ||.| |||.||... .||| |..||.|..
dvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrl
0040439 (Phosphotyrosine protein) phosphatases II 98-186 4.5e-27 90.7 In-house 5-93 (249) alignment 
Range on Protein: 98-186
Range on HMM: 5-93/249.0
CDQHEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
. ...| .   .   .. ..||||||  | .  ..|||||.||.||...|.| |.|||||.||.| |||.|| . ..|||||.|||.|.
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgr
0042113 (Phosphotyrosine protein) phosphatases II 98-187 6.6e-27 89.9 In-house 3-92 (245) alignment 
Range on Protein: 98-187
Range on HMM: 3-92/245.0
CDQHEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
. ...| .   .   .....|.||||     | |.|||||.|..||. .. | |.|||||.||.| |||.|| . ..|||||...|.|.|
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 113-186 1.3e-26 88.3 In-house 58-131 (315) alignment 
Range on Protein: 113-186
Range on HMM: 58-131/315.0
VILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
.|  ..|||.|  |  |...||.|||.|.||| .| ..|.|||.. .|.|.||...|.. . |||||.|||. |
iiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegek
subfamily_PTPRK_pd Subfamily PTPRK 100-187 2e-26 87.6 In-house 39-126 (314) alignment 
Range on Protein: 100-187
Range on HMM: 39-126/314.0
QHEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
...|. . . .|...  ..|||.| .. .|...|||||..| .|. |..|.. ||||. || |.||........ |||||.|||.|.|
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrv
Y_phosphatase Protein-tyrosine phosphatase 112-186 2.2e-26 88.1 Pfam-A 9-81 (235) alignment 
Range on Protein: 112-186
Range on HMM: 9-81/235.0
KVILNEHSRVKLaalADDSD-TDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
...  ...||||    .... .|||||||. ||.....|.|.||||. |..| |||.|..|...|||||.|.|||.
dilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr
Y_phosphatase Protein-tyrosine phosphatase 112-186 2.2e-26 88.1 In-house 9-81 (235) alignment 
Range on Protein: 112-186
Range on HMM: 9-81/235.0
KVILNEHSRVKLaalADDSD-TDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
...  ...||||    .... .|||||||. ||.....|.|.||||. |..| |||.|..|...|||||.|.|||.
dilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 117-187 9.5e-26 85.5 In-house 60-130 (288) alignment 
Range on Protein: 117-187
Range on HMM: 60-130/288.0
EHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
.. ||||  | . ...|||||.|| |... ....| ||||. ||.| |....|.||| |||||.|||.|| 
DekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggkt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 97-186 2.2e-25 84.4 In-house 39-128 (305) alignment 
Range on Protein: 97-186
Range on HMM: 39-128/305.0
KCDQHEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
. ...|.. |.. . ...| ...|..|..  .. |.|||||.|. ||..  .... ||||. ||.| ||.|.| |.| |||||.||| ||
dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggk
0045098 (Phosphotyrosine protein) phosphatases II 112-185 3.3e-25 84.5 In-house 41-102 (278) alignment 
Range on Protein: 112-185
Range on HMM: 41-102/278.0
KVILNEHSRVKlaaladdsdtDYINANYIPGYnsPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
 .. ..|||||          |||||.||.||  |..| |.||||| ||.| |||.|| ....|||||.|||.|
dilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 111-186 6.2e-25 82.8 In-house 35-112 (274) alignment 
Range on Protein: 111-186
Range on HMM: 35-112/274.0
GKVILNEHSRVKL-AALADDSDTDYINANYIPGYNS-PREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
 ... ||.||| | .. ..|.|..||||||| ||.   . ..| ||||| ||.|.||||.......|||||.| |. .
ktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane
subfamily_PTPN12_pd Subfamily PTPN12 111-188 8.5e-25 82.2 In-house 47-124 (290) alignment 
Range on Protein: 111-188
Range on HMM: 47-124/290.0
GKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKVR
  ..  ..|||.|    .. . ||||||.| | ... |..| ||||| |.|| |||||||...|.||. ..|| || .
kDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 112-187 1.2e-24 82.1 In-house 64-139 (298) alignment 
Range on Protein: 112-187
Range on HMM: 64-139/298.0
KVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
..|  ..||| | .  .| ..||||| .. .|.    |.|.|.||. || | |||..|.. . |||||.|.|..|.
diialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldkt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 113-187 1.4e-24 81.5 In-house 29-104 (270) alignment 
Range on Protein: 113-187
Range on HMM: 29-104/270.0
VILNEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
.. . ..||.|. | .|| | ||||||..|.. ......| .|||| |. . ||||||.|.. |||.|.|.|||. 
iLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrk
subfamily_Ptp69D_pd Subfamily Ptp69D 107-186 3.2e-24 80.6 In-house 51-130 (307) alignment 
Range on Protein: 107-186
Range on HMM: 51-130/307.0
AQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
     ...  .. ||||. .  . |.|||||..| ||.  ..|.| |.|. .|..| ||||.|..  .||||..| || .
knRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 110-180 3.4e-24 80.8 In-house 31-101 (284) alignment 
Range on Protein: 110-180
Range on HMM: 31-101/284.0
TGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQ
 |...  ....|||  |     .||||| .| || ..  ..|.||||. |..|.|||||| ..| ||.||.
ighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 111-180 4e-24 80.5 In-house 68-137 (319) alignment 
Range on Protein: 111-180
Range on HMM: 68-137/319.0
GKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQ
....  ....|||  |     .||||| .. || ..  ..|.||||. |..|.|||||| ..| ||.||.
inilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 112-187 5e-23 76.6 In-house 17-92 (250) alignment 
Range on Protein: 112-187
Range on HMM: 17-92/250.0
KVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
..|  ..||| |     | ..||||| .. ||.  . |.| ||||. |. |.|||..|.|.. |||||.|.|..|.
diialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt
0037934 (Phosphotyrosine protein) phosphatases II 112-187 6.4e-22 73.7 In-house 18-88 (243) alignment 
Range on Protein: 112-187
Range on HMM: 18-88/243.0
KVILNEHSRVKLaaladdSDTDYINANYIPGYnsPReFMACQGPLPGTVDD----MWRMIWEKKTSIIVMLTQLVEKGKV
 .....||||||      ...||||||.|...  || . |.|||||.||.|     |||.|| ....|||||.|||.|..
dilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgre
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 116-187 1.2e-21 71.9 In-house 56-127 (315) alignment 
Range on Protein: 116-187
Range on HMM: 56-127/315.0
NEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
 ...||||  . |. | ||||| ||..... . ..| ||||. .|||.|||....|.. |||.|.. |  |.
ldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdki
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 116-187 2.5e-21 70.4 In-house 55-126 (515) alignment 
Range on Protein: 116-187
Range on HMM: 55-126/515.0
NEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
 . .||||  . |. . ||.|| |||.... . ..| |||.. .|||.||........ |.|.|.| |  |.
ydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdki
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 110-187 9.8e-21 68.8 In-house 44-120 (287) alignment 
Range on Protein: 110-187
Range on HMM: 44-120/287.0
TGKVILNEHSRVKLAALAdDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
 ..|.  ...|| |.| . .  .|||||||...|.   .|.|.|||.. || |.||...|.... ....|. ||... 
yadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearl
subfamily_PTPN13_pd Subfamily PTPN13 99-188 1.4e-20 68.8 In-house 32-118 (273) alignment 
Range on Protein: 99-188
Range on HMM: 32-118/273.0
DQHEEKPAAQCTGKVILNEHSRVKLAALADdsdtdYINANYIPG--YNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKVR
 ...|. ..    .|.  ...|||| . .      ||||..|     .   |..||||||| ||.|.|.|.||.|...|.|.|. .|||||.
gkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk
subfamily_ptpA1_pd Subfamily ptpA1 112-186 1.5e-20 68.3 In-house 55-128 (418) alignment 
Range on Protein: 112-186
Range on HMM: 55-128/418.0
KVILNEHSRVKLAALADDSDTDYINANYIPGyNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
...  .|.||.|  . |   .|||||||| |   |..|.. ||||| |. |.|||.||..  |||||..  |. .
nilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencr
subfamily_PTPN6_pd Subfamily PTPN6 112-186 1.8e-20 68.1 In-house 62-137 (306) alignment 
Range on Protein: 112-186
Range on HMM: 62-137/306.0
KVILNEHSRVKLAaLADDSDTDYINANYIP--GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
 ..  .|.||.|.   . ...||||||||     .| ....| || |. || | |||.|.... .|||.|. ||.||
nilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 112-187 1.8e-20 68.0 In-house 54-131 (290) alignment 
Range on Protein: 112-187
Range on HMM: 54-131/290.0
KVILNEHSRVKLAALADDSD--TDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
......  |. |  .... |   .|||| || ||.  ....| |||.. |. | |..||..|..||||||. .|.|||
nivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 116-185 3.7e-20 67.2 In-house 63-130 (297) alignment 
Range on Protein: 116-185
Range on HMM: 63-130/297.0
NEHSRVKLAALADDSDTDYINANYIPGYNSprEFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
 . |||||| . || | ||.|| ...|..   .... | | . ||.|.|.|......|.||||... |. 
ydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerd
subfamily_PTPN3_pd Subfamily PTPN3 118-187 3.9e-20 66.9 In-house 55-124 (280) alignment 
Range on Protein: 118-187
Range on HMM: 55-124/280.0
HSRVKLaalaDDSDTDYINANYI----PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
. ||||    ..|.||||||||.    |. .    ..|.||||. |. |.|.|.||.|.|.|||||.|||.|.|
atrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 109-186 4e-20 67.0 In-house 8-84 (237) alignment 
Range on Protein: 109-186
Range on HMM: 8-84/237.0
CTGKVILNEHSRVKLAALAddSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
  |...  .|||| |      |..|||||.|. |.. .|....|.||||  . ||.|.|.|..| |.||||| |.|. .
rygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegne
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 112-185 4.1e-20 66.5 In-house 53-126 (392) alignment 
Range on Protein: 112-185
Range on HMM: 53-126/392.0
KVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
...  . .||||  . | .|.||.|| |||.... . ..|.||| . ..||.|||....... |.|.|.| |  
nilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd
subfamily_PTPN14_pd Subfamily PTPN14 90-187 2.4e-19 64.4 In-house 35-133 (300) alignment 
Range on Protein: 90-187
Range on HMM: 35-133/300.0
AMMDLIMKCDQHEEKPAAQCTGKVILNEHSRVKLAALADDsDTDYINANYIPGY--NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
  .| .... . .|    . . .|.  |..||.|..  .. .|.||||  |      . |.....||||. || |.|.|.||.....|||||.  |.|| 
kredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 112-183 2.4e-19 64.6 In-house 56-127 (325) alignment 
Range on Protein: 112-183
Range on HMM: 56-127/325.0
KVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVE
 |.  ..||| | .. ||...|||||.|.  .     |.|.| ||. |..|.||.. . ..|..|.| .| .
nvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 90-185 2.7e-19 64.2 In-house 19-113 (283) alignment 
Range on Protein: 90-185
Range on HMM: 19-113/283.0
AMMDLIMKCDQHEEKPAAQCTGKVILNEHSRVKLAALADdsdtDYINANYIP---GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
.. ||  ...  .|..  .   ...  .  ||.| ...     ||||| .||    |.  ......|.||  || |.|.|....| . |||||.| |  
svpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedl
subfamily_PTPN1_pd Subfamily PTPN1 113-187 2.8e-18 60.6 In-house 41-111 (290) alignment 
Range on Protein: 113-187
Range on HMM: 41-111/290.0
VILNEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
|   .|||.||     ..|.|||||. .   .  |...  ||||| ||| .|.|.||.|.  .||| ..|||...
vspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 112-185 3.4e-18 60.6 In-house 55-124 (287) alignment 
Range on Protein: 112-185
Range on HMM: 55-124/287.0
KVILNEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
...  .  || |     . . ||||| .| ||.. ..|.....|.  |. ..|..|.... ..||||.|. |. 
qilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekend
subfamily_PTPN23_pd Subfamily PTPN23 113-187 3.4e-18 60.5 In-house 52-123 (288) alignment 
Range on Protein: 113-187
Range on HMM: 52-123/288.0
VILNEHSRVKLAaladDSDTDYINANYIPGYNS--PrEFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
..  .|.||||     .|  ||||| .. .  .  | .|.| |.||..|. | |.|..|.|.|.||||..  |.|| 
ilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 119-186 4e-18 60.1 In-house 55-124 (301) alignment 
Range on Protein: 119-186
Range on HMM: 55-124/301.0
SR--VKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
 |  .|     | . ..||||.|| ||.. ..|.| |||.  |. |.||.||..|.. |||.|.| |. |
nriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtk
subfamily_CG7180_pd Subfamily CG7180 110-183 4.7e-18 59.8 In-house 48-121 (296) alignment 
Range on Protein: 110-183
Range on HMM: 48-121/296.0
TGKVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVE
  ||.  .. || |  |  ....||||| |. ..  ..|..  ..|   |||. ||.......| .|.||.  .
dvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfd
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 111-186 5.2e-18 60.1 In-house 15-91 (239) alignment 
Range on Protein: 111-186
Range on HMM: 15-91/239.0
GKVILNEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
 ...  .|||| |  |..|  .|||||.|.  |. ||. ..| || .  .  |.|||.|...  .||||| |.|  |
anivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 111-186 5.3e-18 60.0 In-house 14-90 (239) alignment 
Range on Protein: 111-186
Range on HMM: 14-90/239.0
GKVILNEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
 ...  .|||| |  |..|  .|||||.|.  |. ||. ..| || .  .  |.|||.|...  .||||| |.|  |
anivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 113-184 9.3e-18 58.9 In-house 57-128 (439) alignment 
Range on Protein: 113-184
Range on HMM: 57-128/439.0
VILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEK
|   .|.|| |  .     . ||||||| ||  .. ..|.|||   |.||.||...||||. |||||.||| 
vgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 113-186 3.4e-17 57.2 In-house 42-115 (297) alignment 
Range on Protein: 113-186
Range on HMM: 42-115/297.0
VILNEHSRVKLAALAddSDTDYINANYI--PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
..  . .||||      ...|||||.|.  |  ...  ..  ||||  |||| |....|.   .|||...| | |.
ilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr
subfamily_PTPRN_pd Subfamily PTPRN 101-186 1.3e-16 55.1 In-house 53-139 (297) alignment 
Range on Protein: 101-186
Range on HMM: 53-139/297.0
HEEKPAAQCTGKVILNEHSRVKLAALADDSDTDYINANYIPGYnSPRE--FMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
.|.    . . .|.  .|||||| . |.....|||||  |     ||.  ..|.||||. || |.|.|.||. . .||.||.| |.| 
aeknvkknrskavlpydhsrvklkeeasaeksdyinasaildh.dprapayiatqgplastvadfwqmvweqGvvvivnltrleeegv
0049772 (Phosphotyrosine protein) phosphatases II 81-184 1.6e-16 56.4 In-house 23-154 (314) alignment 
Range on Protein: 81-184
Range on HMM: 23-154/314.0
TVLKAEKIKAMMDLIMKCDQHEEKPAAQCTGKVILNEhSRVKLaALADDSDTDYINANYIPGYnspREFMACQGPLPGTVDDM----------WRMI--W
 ||.   . .. .|...  .... .  . . ...  . .||.|    . |..|||||.|. |.   . |.|.||||. ||.|           |||.  .
lvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrg

EKKTSIIVM---------------------LTQLVEK
. .. .|||                     |..| ..
dlnvrdivmsrdevladelsrLdaAlgKtpllildgn
subfamily_CG42327_pd Subfamily CG42327 112-186 1.8e-16 54.7 In-house 37-112 (319) alignment 
Range on Protein: 112-186
Range on HMM: 37-112/319.0
KVILNeHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG-K
 | |  ..|| |   .||  . |..|.|. ||. .|  ..|.| .|  .  |.||..||... .|| ||.| |.| |
vvPlP.etrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGik
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 113-187 3.3e-16 53.8 In-house 65-134 (290) alignment 
Range on Protein: 113-187
Range on HMM: 65-134/290.0
VILNEHSRVklaALADDSDTDYINANYIPGYNSPreFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
|. |. .||    | |  | ||. |||. | ...  |.  ||.|  || |.|||. ..|.. |||| .|.|.|| 
vvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGka
0043147 (Phosphotyrosine protein) phosphatases II 129-181 2.8e-15 51.9 In-house 2-54 (172) alignment 
Range on Protein: 129-181
Range on HMM: 2-54/172.0
DSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQL
|...|||||.|...|  |..| |.||||. |..| |||..|.. ..||.||.|
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel
0041856 (Phosphotyrosine protein) phosphatases II 113-179 3.9e-15 51.4 In-house 10-66 (182) alignment 
Range on Protein: 113-179
Range on HMM: 10-66/182.0
VILNEHSRvklaaladdsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
.. ..|||          | ||||||.. |.  ...| |.||||..|| |..||..| . ..||.||
ilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 102-186 4.3e-15 50.5 In-house 48-121 (288) alignment 
Range on Protein: 102-186
Range on HMM: 48-121/288.0
EEKPAAQCtgkvilnEHSRVKLAalaDDSDTdYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
  .    |       . .||||    ||.|  ||.|| ..  . .| .. .| || ||.. .|.|. |.    ||||..|.||||
ryenlprc.......ditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGk
subfamily_egg_pd Subfamily egg 112-184 4.4e-15 50.2 In-house 48-120 (307) alignment 
Range on Protein: 112-184
Range on HMM: 48-120/307.0
KVILNEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEK
.|  .. |||||         |.| ||.. |     ||. .| ||  ||||.|||.....   |||||  .| 
rvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 117-185 1.3e-14 48.5 In-house 50-119 (281) alignment 
Range on Protein: 117-185
Range on HMM: 50-119/281.0
EHSRVKLAA-LADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
. |||.|   . .   |||| ||||      | ..  |||   |  |.|||||...|. |||| |..|  
disrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 116-185 1.2e-13 45.5 In-house 59-142 (350) alignment 
Range on Protein: 116-185
Range on HMM: 59-142/350.0
NEHSRVKLA--------ALADDSDTDYINANYIPGY------NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
 |||||||              |  |||||||.         |.   ..| |.||| ||||....| . |  .|..||..|| .
YehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 87-187 2.2e-13 44.5 In-house 35-134 (310) alignment 
Range on Protein: 87-187
Range on HMM: 35-134/310.0
KIKAMMDLIMKCDQHEEKPAAQCTGKVILNEHSRVKLAaLADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
|. |  |  .  . ....   .    |.  . |||||  .      ||| |||.        |. .||||  |. |.||||.....  |..| . .|.|.
kldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegr

V
 
p
0051429 (Phosphotyrosine protein) phosphatases II 132-187 4.4e-13 45.0 In-house 4-61 (272) alignment 
Range on Protein: 132-187
Range on HMM: 4-61/272.0
TDYINANYIPGYNS---PREFMACQGPLPGTVDDMWRMiWEKKTSIIVMLTQLVEKGKV
..||||....||..   |. . ...|||| |..| ||. .| . . ||.|....|.|..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 124-187 1.3e-12 42.0 In-house 72-136 (305) alignment 
Range on Protein: 124-187
Range on HMM: 72-136/305.0
AALADDSDTDYINANYIPGYNSP-REFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
  |.. | .||| |||.     | . |...||||  |.|..| |. ..|   |||| . || ||.
vkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 116-181 1.5e-12 42.1 In-house 45-106 (267) alignment 
Range on Protein: 116-181
Range on HMM: 45-106/267.0
NEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQL
 ...|| |     ... .|||| |. ||.  . |.. |.||  |. | . .| ..| ..||.||. 
yddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv
0046846 (Phosphotyrosine protein) phosphatases II 127-187 3.1e-12 42.1 In-house 7-63 (176) alignment 
Range on Protein: 127-187
Range on HMM: 7-63/176.0
ADDSDTDYINANYIPGYnsprEFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKV
 .| | ||||||.| |.     . |.|||||.|. | ..|..| . ...|.||..||.|..
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 114-186 3.6e-12 40.6 In-house 58-127 (305) alignment 
Range on Protein: 114-186
Range on HMM: 58-127/305.0
ILNEHSRVKLaalADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
   .. ||||         .|| |||.     |. |. .| ||  |  |.| | ...|   | || .|.||| 
gcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekga
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 115-188 4.8e-12 40.5 In-house 52-123 (307) alignment 
Range on Protein: 115-188
Range on HMM: 52-123/307.0
LNEHSRVKLAalADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKVR
  ...|. .    |   .||| |||.     |. |...||||  |. ..| |. ..|   ..|| ...| .|..
cqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakik
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 134-185 8.1e-12 39.5 In-house 77-128 (301) alignment 
Range on Protein: 134-185
Range on HMM: 77-128/301.0
YINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKG
 | ||.||    |. |.| ||||. | .|.| |.   .   ||||.| ||| 
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekl
0036282 (Phosphotyrosine protein) phosphatases II 132-185 9.6e-12 40.4 In-house 2-50 (174) alignment 
Range on Protein: 132-185
Range on HMM: 2-50/174.0
TDYINANYIPGYNSPREFMACQGPLPgtvddMWRMIWEKKTSIIVMLTQLVEKG
.|||||... ..  .... |.||||.      |.|..| . ...|||....|.|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 83-185 1.5e-11 38.8 In-house 14-113 (285) alignment 
Range on Protein: 83-185
Range on HMM: 14-113/285.0
LKAEKIKAMMDLIMKCDQHEEKPAAQCTGKVILNEHSRVKLaalaDDSDTDYINANYI--PGYNSpREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQ
|. .|||  |        .| .|  .    |   | .|| |     . | ||| |...  || .    ... ||||| |. |.|.||...| . ..||  
lhqdkikgymppnctytayeanpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlct

LVEKG
|.| |
lfegg
0049260 (Phosphotyrosine protein) phosphatases II 139-186 3.1e-11 38.7 In-house 1-48 (152) alignment 
Range on Protein: 139-186
Range on HMM: 1-48/152.0
YIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
.|.||. |.||.|.|||.| |..| |||..| . ..|||||.|.|.||
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 112-177 3.3e-10 34.0 In-house 53-115 (347) alignment 
Range on Protein: 112-177
Range on HMM: 53-115/347.0
KVILNeHSRVKlAALADDSDTdYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVM
.|.|    . |  . |||..| |||| .|   |. .|..  | ||| || |.|.|.   | . .| 
rvvls.peksk.nsraddvet.yinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 130-183 9.2e-10 32.3 In-house 88-143 (349) alignment 
Range on Protein: 130-183
Range on HMM: 88-143/349.0
SDTDYINANYI--PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVE
   |||||||.  . ..  . ..| | ||| |||| ...|  ..  ... |..  |
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 80-182 2.7e-09 30.2 In-house 9-78 (169) alignment 
Range on Protein: 80-182
Range on HMM: 9-78/169.0
KTVLKAEKIKAMMDLiMKCDQHEEKPAAQctgkvILNEHSRVKLAALADDSDTDYINAnyipgynsprefmacqgplpgtvddmwRMIWEKKTSIIVMLT
| ..|. . . .|   . |.. ...||.      .   | ||||  . .|  .|||||                           |||||  .|.||.| 
kefmktieynnfmae.ltcnetknrpagp.....lapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlg

QLV
.  
dtd
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 80-182 3.5e-09 29.7 In-house 8-77 (169) alignment 
Range on Protein: 80-182
Range on HMM: 8-77/169.0
KTVLKAEKIKAMMDLiMKCDQHEEKPAAQctgkvILNEHSRVKLAALADDSDTDYINAnyipgynsprefmacqgplpgtvddmwRMIWEKKTSIIVMLT
| ..|. . . .|   . |.. ...||.      .   | ||||  . .|  .|||||                           |||||  .|.||.| 
kefmktieynnfmae.ltcnetknrpagp.....lapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlG

QLV
.  
dtd
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 115-186 5.9e-09 29.8 In-house 45-115 (332) alignment 
Range on Protein: 115-186
Range on HMM: 45-115/332.0
LNEHSRVKLAAlaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDD-MWRMIWEKKTSIIVMLTQLVEKGK
  .||||.||   .|   |. ||... ||.    .. .| |.    .  .|||. |.| |.|... .. || |
cfdhsrvelap..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
0051082 (Phosphotyrosine protein) phosphatases II 132-185 1.9e-08 29.6 In-house 3-47 (151) alignment 
Range on Protein: 132-185
Range on HMM: 3-47/151.0
TDYINANYIPGYnspreFMACQGPLPgtvdDMWRMIWEKKTSIIVMLTQLVEKG
.||||..|. |.     . ...|||.    | .....| . . ||.|....| |
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 112-178 2.1e-08 28.2 In-house 55-114 (303) alignment 
Range on Protein: 112-178
Range on HMM: 55-114/303.0
KVILNEHSRVKLaaladdSDTDYINANYIPgYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
 ||  .||.|||      ||. || |.|.   .| .  .  | ||. |  |.|.|| |.|   ...|
dvicldhskvkl......sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 142-184 2e-07 24.7 In-house 231-273 (440) alignment 
Range on Protein: 142-184
Range on HMM: 231-273/440.0
GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEK
||     |.| | ||  || |.||.. . . | |.|| || .|
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk
0044763 (Phosphotyrosine protein) phosphatases II 117-185 2.2e-07 26.2 In-house 3-62 (178) alignment 
Range on Protein: 117-185
Range on HMM: 3-62/178.0
EHSRVKLAALADDSDTDYINANYIPGYnsprEFMACQGPlpgtvDDMWRMIWEKKTSIIVMLTQLVEKG
...||.|  | .   .|||||..| ..     ......|      | .....| . . ||.||. .| |
drtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 113-183 5.7e-07 23.4 In-house 105-173 (244) alignment 
Range on Protein: 113-183
Range on HMM: 105-173/244.0
VILNEHSRVKLAAlaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVE
 .  . .|| |.         |||| ..       |..  | ||  |  |.|.|. |..  ..|.|  . |
glpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 122-183 8.8e-07 23.3 In-house 11-64 (130) alignment 
Range on Protein: 122-183
Range on HMM: 11-64/130.0
KlaaladdsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVE
.        . .||||...   .  .|..  | ||  |  |.|.|. |.   ..|.|  . |
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 126-186 9e-07 22.9 In-house 62-121 (312) alignment 
Range on Protein: 126-186
Range on HMM: 62-121/312.0
LADDSdTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGK
|| |    || ||..     |  |...||||  |.  .|..     .. |..|. .|| | 
lagde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgs
Tn7_Tnp_TnsA_C TnsA endonuclease C terminal 115-171 8.8e-06 12.2 Pfam-A 36-74 (79) alignment 
Range on Protein: 115-171
Range on HMM: 36-74/79.0
LNEHSRVKLAALADDSDTDYinanyipgynsprefmacQGPLPGTVDDMWRMIWEKK
|....   |||| .. |.||                  . .   ..|. ...|..|.
lkkngntslaallakldndy..................nlepgealdlirqliAtkr