Gene PTPRB-5 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP071_AA protein Get Run
SpurP071_AA_541-869 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 493-719 2.9e-122 402.3 In-house 2-228 (293) alignment 
Range on Protein: 493-719
Range on HMM: 2-228/293.0
SHSKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQG
..||||.|.|||.|. .||||||.||.|||.|...||||||...| ..|||||||.||||||.|||||||||.|.|..|||||||||||||||||.|.||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTM
|||.||||.|||.||||.||||||||||||||.||.||||||..||.||.|.|...| .....|||||..|....|.||..||||.|||||||||||.|.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

LDFVRTVREAIQKTASDRPIVAHCSAG
|||||||||||.||||.||||.|||||
ldfvrtvreaiektaskrPivvhCsaG
subfamily_PTPRD_pd Subfamily PTPRD 495-719 5.2e-87 287.8 In-house 2-224 (564) alignment 
Range on Protein: 495-719
Range on HMM: 2-224/564.0
SKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVgKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPL
||||  .... |. ..||.||..|.||| .|.   .   . .| . .|.||||. ||..|.||||.| ..  |...|||||..| ||.......| ||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTM
. |..| |||.||...|.|||||.|.|||| |||.|||.. .. |||...|.... ... . .||.|...  . .| |. .|.||.|||||||||.. ..
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LDFVRTVREAIQktASDRPIVAHCSAG
||..|.||.. .      ||| |||||
Ldlirkvralne..pdagPivVhCSaG
subfamily_PTPRB_pd Subfamily PTPRB 719-879 9.3e-86 282.5 In-house 132-292 (293) alignment 
Range on Protein: 719-879
Range on HMM: 132-292/293.0
GAIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGR
| .||.||||||..||.||.|.|...| .....|||||..|....|.||..||||.||||||||.||.|.|||||||||||.||||.||||.||||||||
gkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGR

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
|||.||||||.||..|.||.|||||..|.|..||..|||||||||||.||.||||..|||.
tGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeeek
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 498-719 6.3e-77 253.7 In-house 2-223 (318) alignment 
Range on Protein: 498-719
Range on HMM: 2-223/318.0
IVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGT
| ....| |  |.... .  ..|||...  . .  . . .|| ||.||||..|||.|.|.||||  |... ..||||||||.||.. ....|.|.||| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDF
..|.|||.||.....||||||..|.||.|.| ||| . .. .||...| ..   .....|.|||....   .| |.  |||. ||||.||||.. ..||.
ieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

VRTVREAiQKTASDRPIVAHCSAG
||.|..| |.... .||| |||||
vrqvska.qqksgagpivvhCsaG
0051299 (Phosphotyrosine protein) phosphatases II 496-719 1.3e-75 249.8 In-house 3-229 (288) alignment 
Range on Protein: 496-719
Range on HMM: 3-229/288.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
..| ..... .. ...|..  .. ||..|.. .  |  . .||   |. |||...||||.||||||  | .....|||||.||.|||..|.|.|.|||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPEKT
.||.| |||.||.....|||||.|||.|..||. |||   ...||| |.|     ...|....|.. ..      ...| |. |..|...|||||||. .
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

WTMLDFVRTVREAIQktASDRPIVAHCSAG
  .|||.| ||.|..  ... |.| |||||
ellldflrlvrkala..sgggpvvVHCsaG
0050432 (Phosphotyrosine protein) phosphatases II 505-719 1.5e-72 239.9 In-house 31-242 (308) alignment 
Range on Protein: 505-719
Range on HMM: 31-242/308.0
GHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaaladDSDTDYINANYIPGY--NSPREFMACQGPLPGTVDDMW
 ..  .||..  .. ||. |.. |  .  . .||   |. |||...||||.||||||     |...|||||.|..||  ..||.| |.|||||.||.| |
llkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAD--YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRT
||.|| ....|||||.|||.|..||..||| .   ....|| ..| .   ...|....|.. ..   ..| |..|..|...|||||||...  .|||.. 
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VREAIqktaSDRPIVAHCSAG
||. .    .. ||| |||||
vrksl....pggpivVHCsaG
0046845 (Phosphotyrosine protein) phosphatases II 518-719 2.3e-71 235.8 In-house 2-214 (284) alignment 
Range on Protein: 518-719
Range on HMM: 2-214/284.0
FTEEYDEIRLVGKDQ--AIVSALEMVNRAKNRFTNILPYEHSRVKLAALADD-SDTDYINANYIPGY-----NSPREFMACQGPLPGTVDDMWRMIWEKK
. ||. |.. .  ..   .  ||   |. |||...||||.||||||  | .| .|.|||||.|..||     .....|.|.|||||.||.| |||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKT
...|||||.|||.|..||. ||| . ...||| ..| .   ...|....|.....    ..| |..|..|..||||||||. .  .|.|.|.|||.....
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

ASDRPIVAHCSAG
 .. ||| |||||
pgggpivVHCsaG
0047943 (Phosphotyrosine protein) phosphatases II 510-719 3.6e-71 235.2 In-house 6-215 (273) alignment 
Range on Protein: 510-719
Range on HMM: 6-215/273.0
MKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKK
.|...  .. ||..... . ..  .  ||   |. |||...||||.||||||    .|...|||||.|..|||..|.|.|.|||||.||.| |||.||..
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

TSIIVMLTQLVEKGKIKCHEYWPADYN--PVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQK
...|||||.|||.|..||. ||| . .  ..||| ..| .   ...|....|.. ..    .| |. |..|...|||||||. .  .|.|.. ||.|...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

TASDRPIVAHCSAG
. |. |.| |||||
lpsngpvvVHCsaG
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 496-720 8.1e-71 233.7 In-house 3-227 (319) alignment 
Range on Protein: 496-720
Range on HMM: 3-227/319.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDqAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
..| ..... .. .... ..  . .|. ...  ..|  . || .  |. |||..|||.|...||.|..| .  ..|||||..| ||.  ..|.| |.|| 
teievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ-GDEI--RKLTQYHFMSWPDHGVPEKTWTM
 |..|.|||.||...||.||||.||||.|.|...|||   |...|| . | ..  .. ....||.... .  .|.  |.........||||.||||. ..
ntiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

LDFVRTVREAIQKTaSDRPIVAHCSAGA
||... .|.. .|| ...||| |||||.
ldllkrirksrekt.qsgPivvhCsaGv
0039614 (Phosphotyrosine protein) phosphatases II 494-719 9.1e-71 234.0 In-house 10-232 (297) alignment 
Range on Protein: 494-719
Range on HMM: 10-232/297.0
HSKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDqaIVSALEMVNRAKNRFTNILPYEHSRVKLAALAD-DSDTDYINANYIPGYNS-PREFMACQ
 | || |. .. .....||.|  .. .|. |.  .  |  .. ||  .|. |||...||||.||||||  . . | |.|||||.|..||.  .|.| |.|
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKiKCHEYWPADYNpvTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWT
||||.||.| |||.|| ....|||||.|||.|. ||..||| . .  ||| ..| .   ...|....|..... ..| |..|......|||||||. . .
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslel

MLDFVRTVREAIQKTASDRPIVAHCSAG
.|.|.. ||||.... ...|.. |||||
lleflelvrealaelpkggpvlVHCsaG
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 505-719 4.9e-70 230.8 In-house 10-222 (288) alignment 
Range on Protein: 505-719
Range on HMM: 10-222/288.0
GHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRM
 .  ...|..   |.|||. .  ..|...   . . ||  |||. |||||.. ||||  | . ...|||||.|| |... ....| ||||. ||.| |..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQ
..|.||| |||||.|||.|| ||.||||.. .|. |||..| ..  .. ...| |.. . .  . ...|||....|||||||| .  .|...|.|  | |
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

KTasDRPIVAHCSAG
.     ||. |||||
ad..tgpiivhCsaG
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 510-719 1.6e-69 229.1 In-house 9-218 (281) alignment 
Range on Protein: 510-719
Range on HMM: 9-218/281.0
MKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKK
......  |.|||.... .| |.. ... .  |. |||..||  |...|||..   ....|||||||..|||....|..|.|||.| .....|.|.||.|
lsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

TSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSI-SQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiQKTAS
 |.|||.|. .|.||.||| ||| | . ..|| ..|. .| ..  ... |.|..  .. | |...| ....|||||||..|  .|.| . |... ... .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl.tekkt

DRPIVAHCSAG
. |.| |||||
kaplvihCsaG
0040438 (Phosphotyrosine protein) phosphatases II 502-719 8.7e-69 227.5 In-house 4-219 (317) alignment 
Range on Protein: 502-719
Range on HMM: 4-219/317.0
KFEGHYGRMKADSDFRFTEEYDEIRLVGKDqAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDM
... .. .... .  .. ||. ... . .|  .  |.  .|. |||...||||.||||||  |  | |.|||||.|..|.| .|.| |.|||||.||.| 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTV
|||.|| ....|||||.|.|.|..||..|||   ...||| ..| ..  ........|.. ..  ...| |..|..|...|||||||. . ..|||.. |
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

REAIQktASDRPIVAHCSAG
|||..   .. |.. |||||
reale..dpggpvlVHCsaG
0036941 (Phosphotyrosine protein) phosphatases II 511-719 9.9e-69 227.2 In-house 8-217 (297) alignment 
Range on Protein: 511-719
Range on HMM: 8-217/297.0
KADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKT
|...  .. .|..|.  . ..  .  ||   |. |||...||||.|.||||    ||...|||||.|..||. .|.|.|.|||||.||.| |||.|| ..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

SIIVMLTQLVEKGKIKCHEYWPAD-YNPVTYGSIQVSVQALQQ--YDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQK
..|||||.|||.|..||..||| .  ...||| ..| ..  ..  .|....|.. ..   ..| |..|..|...|||||||| . ..|||.. ||.....
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

TASDRPIVAHCSAG
. |. |.. |||||
lpsggpvlVHCsaG
0045450 (Phosphotyrosine protein) phosphatases II 494-719 2.1e-68 226.7 In-house 5-244 (307) alignment 
Range on Protein: 494-719
Range on HMM: 5-244/307.0
HSKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGK--DQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADD-SDTDYINANYI--------PGYN
.|..| . |.. .. ....|.  .. .|. ... | .     . .||  .|. |||...||||.|.||||  | .. .|.|||||.|.        .||.
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMS
..|.|.|.|||||.||.| |||.||.....|||||.|||.|..||..||| .  ..||| ..| .   ...|....| . ..   . .| |..|..|. .
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAG
|||||||. . ..|||.. ||.|.... .. |.. |||||
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG
0043336 (Phosphotyrosine protein) phosphatases II 502-719 2.8e-67 222.4 In-house 6-220 (278) alignment 
Range on Protein: 502-719
Range on HMM: 6-220/278.0
KFEGHYGRMKADSDFRFTEEYDEIRLVGKdQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDM
... .. ......  .. .|. |.. . .   .  || . |. |||...||||.||||||  |  | |.|||||.|..||| ||.| |.|||||.||.| 
dllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPadYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTV
|||.|| ....|||||.|||.|..||..|||   ...||| ..| ..  ...|....| . ..  . .| |. |.||...|||||||| . ..|||...|
wrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

REAIQktASDRPIVAHCSAG
|||..   |. |.. |||||
reale..dsngpvlVHCsaG
subfamily_PTPRG_pd Subfamily PTPRG 499-722 8.5e-67 220.6 In-house 2-233 (563) alignment 
Range on Protein: 499-722
Range on HMM: 2-233/563.0
VLNKFEGHYGRMKADSDFRFTEEYDEIRL--VGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDT-DYINANYIPGYNSPREFMACQGPLP
 ...|. |   ..||.| .|.||....    . ||  . .. .  |. ||| .||..|..|||||. |..  .. |||||||| ||.  ..|.| ||||.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPVTYGSIQVSVQALQQYD-----HWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPE
 |.|| ||||||....||||.|.|||.|. ||. |||.  ...|||..||  .. ..       . ||... . ....    .. .|||. .||||||||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

KTWTMLDFVRTVREAiqKTASDRPIVAHCSAGAIK
..   | ||.    |  . |   ||| |||||. .
hslpvLifvkkssaa..nkaeaGPivvHcsaGvgr
subfamily_PTPRA_pd Subfamily PTPRA 495-720 1.4e-65 216.4 In-house 11-239 (330) alignment 
Range on Protein: 495-720
Range on HMM: 11-239/330.0
SKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPL
  |. ..|.|    . .||   .| ||.. .     . ..  | .  |. |||. |||||..||| |. .    ..||||| .| ||.   .|.|.|||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

PGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS-QGDE-----IRKLTQYHFMSWPDHGVPEK
  ||.|.||||||.|.. |||||.| |. . ||. ||| .   |||| |.|.|.  .   .. .|.| .  ..|.      | ..|.|| |||| ||| .
eetvedfwrmiweqksativmltelkerkeekcaqywPde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

TWTMLDFVRTVREAIQKTASdrPIVAHCSAGA
.  ||.... |..  |..|.  ||| |||||.
piGmlkllkkvkklnqqsag..pivvhcsaGv
DSPc_SM00195 518-719 1.6e-63 209.8 In-house 2-205 (263) alignment 
Range on Protein: 518-719
Range on HMM: 2-205/263.0
FTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
. ||.....   ... . .| .  |..|||..|||||.|.||||    .....|||||||| |.|..... |.||||| ||.| |||.||.|..||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTasDRPIV
. .|.||.||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .|||||||..|  .|...|.|..  ...  . |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

AHCSAG
 |||||
VhCsaG
PTPc_SM00194 518-719 1.6e-63 209.8 In-house 2-205 (263) alignment 
Range on Protein: 518-719
Range on HMM: 2-205/263.0
FTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
. ||.....   ... . .| .  |..|||..|||||.|.||||    .....|||||||| |.|..... |.||||| ||.| |||.||.|..||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTasDRPIV
. .|.||.||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .|||||||..|  .|...|.|..  ...  . |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

AHCSAG
 |||||
VhCsaG
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 496-720 9.4e-63 207.0 In-house 4-223 (315) alignment 
Range on Protein: 496-720
Range on HMM: 4-223/315.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRlVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
.|| |...  .  . || .   | ..|. |   |. . .  | .. |. |||. ||..|..|||.|  |  |...||.|||.|.||| .| ..|.|||..
qpipldqlityvaqkkastkngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADynPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDF
 .|.|.||...|.. . |||||.|||. | |. .||| .   |.|| | |. .  ...... .| .|.  ||.||.. |.|. |||| |||. | .....
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnl

VRTVREaiQKTASDRPIVAHCSAGA
.|||.    .|.|  .|| ||||| 
irtvkq..hhtnsvgaivvhcsaGv
subfamily_PTPN12_pd Subfamily PTPN12 535-719 5.7e-62 204.2 In-house 33-217 (290) alignment 
Range on Protein: 535-719
Range on HMM: 33-217/290.0
VSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAD
 .. ...|..|||. .||||..|||.|    .. . ||||||.| | ... |..| ||||| |.|| |||||||...|.||. ..|| ||.||. |||  
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

-YNPVTYGSIQVSVQALQQYD-HWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQktASDRPIVAHCSAG
  .....|...|.... .. |  ..|| . . . .| ||..|.|...|||||||... ..|.....|||  .  ..| |.| |||||
geeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaG
0040439 (Phosphotyrosine protein) phosphatases II 539-719 1.1e-61 203.9 In-house 8-189 (249) alignment 
Range on Protein: 539-719
Range on HMM: 8-189/249.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPV
 ..|. |||...||||.||||||  | .  ..|||||.||.||...|.| |.|||||.||.| |||.|| . ..|||||.|||.|..||..|||   ...
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsl

TYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAG
.|| ..| .   ...|....|.. ..  . .| |. ..... .|||||||. . ..|||.. ||.|.... .. |.. |||||
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaG
0045098 (Phosphotyrosine protein) phosphatases II 512-719 1.3e-61 203.8 In-house 3-216 (278) alignment 
Range on Protein: 512-719
Range on HMM: 3-216/278.0
ADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKlaaladdsdtDYINANYIPGYnsPREFMACQGPLPGTVDDMWRMIWEKKTS
|... ... |.....| |  . |  ||   |..|||...||||.|||||          |||||.||.||  |..| |.||||| ||.| |||.|| ...
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

IIVMLTQLVEKGKIKCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPEKT--WTMLDFVRTVREAI
.|||||.|||.|..||..||| . ...||| ..| ..  ...|....| . .       ...| |..|..|...|||||||. .  . .|.... .|||.
vivmltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefireal

Q-----------KTASDRPIVAHCSAG
.              |. |.. |||||
kllaslllsslllldsggpvlVHCsaG
subfamily_PTPN6_pd Subfamily PTPN6 517-719 2.2e-61 202.5 In-house 27-237 (306) alignment 
Range on Protein: 517-719
Range on HMM: 27-237/306.0
RFTEEYDEIRLVGKDQAI--VSALEMVNRAKNRFTNILPYEHSRVKLAaLADDSDTDYINANYIP--GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSI
 |.||..|..   . . .    .  . |. |||. ||||..|.||.|.   . ...||||||||     .| ....| || |. || | |||.|.... .
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTA--
|||.|. ||.|| ||  |||.  .  .||.|.|.  . .. .....||.|.|   ...| |.. |||| ||||||||... ..|||...|..  ....  
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

SDRPIVAHCSAG
. .||| |||||
eagpivvhCsaG
0042113 (Phosphotyrosine protein) phosphatases II 539-719 4.1e-61 201.8 In-house 6-186 (245) alignment 
Range on Protein: 539-719
Range on HMM: 6-186/245.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPV
 ..|. |||...||||.|.||||     | |.|||||.|..||. .. | |.|||||.||.| |||.|| . ..|||||...|.|..||..|||   ...
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

TYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKtASDRPIVAHCSAG
||| ..| .   ...|....|.....  . || |. ..||...|||||||. . ..|||.. ||.|...  |. |.. |||||
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaG
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 510-720 5.9e-61 201.3 In-house 21-234 (298) alignment 
Range on Protein: 510-720
Range on HMM: 21-234/298.0
MKADSDFRFTEEYDEIRLVGK---DQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIW
.|. .  ....|. ... | .   ..    | .  |. |||...|.....||| | .  .| ..||||| .. .|.    |.|.|.||. || | |||..
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaIQ
|.. . |||||.|.|..|.|.|.||| . .  |||.|.||... ...   ..|.. .|. .  . |.. | ||.||||.||||.. ..||..| ||   |
eedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sq

KTASDRPIVAHCSAGA
. | ..|.. .|||| 
qqagnkpvivqCsaGv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 496-719 2.1e-60 199.4 In-house 2-226 (305) alignment 
Range on Protein: 496-719
Range on HMM: 2-226/305.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVgKDQAIVsALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
|.| |.... .   ....||  . ..|...    ...  |   . .|.||||...| .....|..|..  .. |.|||||.|. ||..  .... ||||.
kiialddlaayikearvysdkgleaqykslyee.eesidv.gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-VTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWT
 ||.| ||.|.| |.| |||||.||| || ||. |||   .  . .|...| ..  ...  ...|...||.    .| | ..||.. .|||||||... .
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

MLDFVRTVREAiQKTASDRPIVAHCSAG
.|.... |... ||   . |.. |||||
llslikrvqkd.qkkdkgvpllVhCsag
subfamily_PTPRK_pd Subfamily PTPRK 506-720 4.8e-59 194.7 In-house 12-221 (314) alignment 
Range on Protein: 506-720
Range on HMM: 12-221/314.0
HYGRMKADSDFRFTEEYDEIrLVGkdqaIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMI
.   .|.   . | |||. . . |      .| .  ||.|||...||.|..|||.| .. .|...|||||..| .|. |..|.. ||||. || |.||..
siallkraegygfkeeyesl.feg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlv

WEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPvtYGSIQVSVQALQQYDHWVIREFSISQ----GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVRE
...... |||||.|||.|..|| .||| | .   || |.| .   .     |.| |....     .|||.. |..|..||||.|| .  ..|..|| | .
ydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkk

AIQKtaSDRPIVAHCSAGA
  ..  .. .|| ||||||
sqee..eaGrivvhCsaGa
subfamily_PTPRD_pd Subfamily PTPRD 721-880 7.2e-59 194.9 In-house 131-289 (564) alignment 
Range on Protein: 721-880
Range on HMM: 131-289/564.0
IKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVGR
 |||.|||.. .. |||...|.... ... . .||.|...  . .| |. .|.||.||||||||... ..||..|.||.. .      ||| ||||||||
vkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGR

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDT
|||.|..| ... ..|.. .||.... ..| |||.|||||.||||||| ... |  |..| .
TGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteve
subfamily_Ptp69D_pd Subfamily Ptp69D 497-720 8.4e-59 194.2 In-house 3-230 (307) alignment 
Range on Protein: 497-720
Range on HMM: 3-230/307.0
PIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPG
.| . . |  .   | |.|| ...||...     |.  . . .  |  |||. .| .... ||||. .  . |.|||||..| ||.  ..|.| |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD-------EIRKLTQYHFMSWPDHGVPEKT
|..| ||||.|..  .||||..| || . ||. ||| . . | ||.| | .   .. ....|||...|. .       . ||..|||...|.|  ||| .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

WTMLDFVRTVREAIQKTasDRPIVAHCSAGA
 ..|.... |||  ..     ||| |||||.
rgllklieqvrelykln..rsPivvhCsaGv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 535-720 8.6e-59 194.0 In-house 36-220 (515) alignment 
Range on Protein: 535-720
Range on HMM: 36-220/515.0
VSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPA-
  | | .|  |||. |||||. .||||  . |. . ||.|| |||.... . ..| |||.. .|||.||........ |.|.|.| |  |||| .|||  
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk

DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTAsdRPIVAHCSAGA
  . | .|||.|.. .|.     ..|.. . .||..| .||.||  |||.|||..| ..| ... |.   .. .   |.. |||||.
pgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 540-720 1.8e-58 193.3 In-house 59-235 (319) alignment 
Range on Protein: 540-720
Range on HMM: 59-235/319.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTqlvekgKIKCHEYWPADYNpVT
  |. |||..|||......|||  |     .||||| .. || ..  ..|.||||. |..|.|||||| ..| ||.||      | || .||| . . ..
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ik

YGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGA
..  .|.|..... . .|.|.. .|.     .|||.||.||. |||.|||. .  .. .|. ||   .|    ..|| |||||.
eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGv
subfamily_PTPN9_pd Subfamily PTPN9 519-719 2.4e-58 192.5 In-house 19-233 (297) alignment 
Range on Protein: 519-719
Range on HMM: 19-233/297.0
TEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQ
..|| |||       .  .   .|  |||.|..| |...||.|| . .|. .||||||.. ||. .. |.| ||||. ||.| |||.||... .||| |.
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

LVEKGKIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQ-----------
.||.|..|| .|||  . .   .|...||.   ........| . |.  . .|.||.| . |.||||.|||. . ..||....|||.             
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewk

KTASDRPIVAHCSAG
  .|. ||| |||||
ghpsgPPivvhcsaG
Y_phosphatase Protein-tyrosine phosphatase 542-720 6.3e-58 191.3 Pfam-A 1-181 (235) alignment 
Range on Protein: 542-720
Range on HMM: 1-181/235.0
NRAKNRFTNILPYEHSRVKLaalADDSD-TDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWP-ADYNPVT
|. |||...||||...||||    .... .|||||||. ||.....|.|.||||. |..| |||.|..|...|||||.|.|||. ||..||| .. ...|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIqkTASDRPIVAHCSAGA
||.|.| ..   . . .....|...... .|    |...|.|. .||||||||..  .||..| |..    .|.. |.| |||||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGv
Y_phosphatase Protein-tyrosine phosphatase 542-720 6.3e-58 191.3 In-house 1-181 (235) alignment 
Range on Protein: 542-720
Range on HMM: 1-181/235.0
NRAKNRFTNILPYEHSRVKLaalADDSD-TDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWP-ADYNPVT
|. |||...||||...||||    .... .|||||||. ||.....|.|.||||. |..| |||.|..|...|||||.|.|||. ||..||| .. ...|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIqkTASDRPIVAHCSAGA
||.|.| ..   . . .....|...... .|    |...|.|. .||||||||..  .||..| |..    .|.. |.| |||||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGv
0037934 (Phosphotyrosine protein) phosphatases II 537-719 1.2e-57 190.6 In-house 5-188 (243) alignment 
Range on Protein: 537-719
Range on HMM: 5-188/243.0
ALEMVNRAKNRFTNILPYEHSRVKLaaladdSDTDYINANYIPGYnsPReFMACQGPLPGTVDD----MWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWP
|| ..|. |||...||||.||||||      ...||||||.|...  || . |.|||||.||.|     |||.|| ....|||||.|||.|..||..|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

adyNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQK------TASDRPIVAHCSAG
   ..|||| ..| .   ...|....|.....    .|. |  ..||...|||||||. .  .|||.. ||| |..        |..|.. |||||
...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 541-720 1.2e-57 190.5 In-house 24-199 (284) alignment 
Range on Protein: 541-720
Range on HMM: 24-199/284.0
VNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTqlvekgKIKCHEYWPADYNpVTY
 |. |||...||......|||  |     .||||| .| || ..  ..|.||||. |..|.|||||| ..| ||.||      | || .||| . . ...
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ike

GSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGA
.  .|.|..... . .|.|.. .|.     .|||..|.||. |||.|||. .  .. .|. ||   .|    ..|| |||||.
erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 518-720 2.3e-57 189.2 In-house 21-221 (315) alignment 
Range on Protein: 518-720
Range on HMM: 21-221/315.0
FTEEYDEIRLVGKDqAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
|.||. ..          .| | .|  |||. ||||....||||  . |. | ||||| ||..... . ..| ||||. .|||.|||....|.. |||.|
fseefhdlpdPdiy.rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

QLVEKGKIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHC
.. |  ||||  |||  . . | .|||.|..  |..    |.|.. . ...| |..||..|  |||.||...| ..| ... |.    .   . ... ||
kkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhc

SAGA
|||.
saGv
subfamily_PTPN3_pd Subfamily PTPN3 521-719 8.6e-57 187.2 In-house 20-218 (280) alignment 
Range on Protein: 521-719
Range on HMM: 20-218/280.0
EYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYI----PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
.....    .. ||  |    | .|||. .||||.. ||||    ..|.||||||||.    |. .    ..|.||||. |. |.|.|.||.|.|.||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVA
|.|||.|..|||.|||   . ..||...| ..  ..   .|.||. ... .  | ||..|  ...|||||||...  .|.||..||..  ......|.| 
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePvvv

HCSAG
|||||
hCsaG
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 721-872 1.2e-56 186.9 In-house 130-279 (288) alignment 
Range on Protein: 721-872
Range on HMM: 130-279/288.0
IKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSAGVGRTG
 ||.||||.. .|. |||..| ..  .. ...| |.. . .  . ...|||....|||||||. .  .|...|.|  | |.     ||. ||||||||||
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtg

TYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
|.|||| |..|..|.||||..|.....|.||. .|||.|||.||.|....| 
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 539-720 3.7e-56 185.1 In-house 6-186 (250) alignment 
Range on Protein: 539-720
Range on HMM: 6-186/250.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIkCHEYWPADyNPV
.. |. |||...|.....||| |     | ..||||| .. ||.  . |.| ||||. |. |.|||..|.|.. |||||.|.|..|  .|.|||.. .. 
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve.kae

TYGSIQVSVQALQQYDHWVIREFSISQGDEIRK--LTQYHFMSWPDHGVPEKTWTMLDFVRTVReAIQKTASDRPIVAHCSAGA
.||...||.   ...  ...|.. .|.  .  .  . |.||..||| ||||.. ..|.... |. | |. | ..|.. .|||| 
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq.asqqqagnaPvivqCsaGv
subfamily_PTPN13_pd Subfamily PTPN13 519-719 1.2e-54 180.5 In-house 14-212 (273) alignment 
Range on Protein: 519-719
Range on HMM: 14-212/273.0
TEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADdsdtdYINANYIPG--YNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
.||..|.| .   .   .. .  |..|||. |.|||...|||| . .      ||||..|     .   |..||||||| ||.|.|.|.||.|...|.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQLVEKGKIKCHEYWPADYN-PVTY-GSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaIQKtaSDRPI
|. .||||.||| |||   | ...  . ..|..  .|..| .|.|.. ..  .  | |.... .|..||||||| ..  .| ||. ||. .|.  .  ||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqt..dagPi

VAHCSAG
| |||||
vvhcsaG
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 542-719 4.4e-54 178.4 In-house 28-211 (274) alignment 
Range on Protein: 542-719
Range on HMM: 28-211/274.0
NRAKNRFTNILPYEHSRVKL-AALADDSDTDYINANYIPGYNS-PREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP--
.  |||...||| |.||| | .. ..|.|..||||||| ||.   . ..| ||||| ||.|.||||.......|||||.| |. . ||..|.| . .   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASD-RPIVAHCSAG
  .|| ... |.   . ... .|......  . |... | . .|||| .|... |.||.|. |.|. ....    |.| |||||
serygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 720-879 3.9e-52 172.3 In-house 128-287 (318) alignment 
Range on Protein: 720-879
Range on HMM: 128-287/318.0
AIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVG
 .|.| ||| . .. .||...| ..   .....|.|||....   .| |.  |||. ||||.|||... ..||.||.|..| |.... .||| |||||||
kakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska.qqksgagpivvhCsaGvG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
|||..||.| |.. ....  .|.|... ..| ||| |||||.||.||.. ... |  |. | 
rtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 541-719 6.7e-52 171.1 In-house 19-207 (270) alignment 
Range on Protein: 541-719
Range on HMM: 19-207/270.0
VNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP--
 ... ||...|||  ..||.|. | .|| | ||||||..|.. ......| .|||| |. . ||||||.|.. |||.|.|.|||. ||  ||||. .   
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

-VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTW------TMLDFVRTVREAIQKTASDRPIVAHCSAG
 ...| |.| ... .. . .....  . .  |.|.|. ... .|||||||...        .|  .|.||.  ....   |.. |||||
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG
0046845 (Phosphotyrosine protein) phosphatases II 720-874 8.8e-52 171.6 In-house 116-276 (284) alignment 
Range on Protein: 720-874
Range on HMM: 116-276/284.0
AIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGV
 .||. ||| . ...||| ..| .   ...|....|.....    ..| |..|..|..||||||||. .  .|.|.|.|||..... .. ||| ||||||
rekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRTGTYIALDRLMQAMQEND---YIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||.|||| |.. .....    .|...... .|.||..||||. ||.|..|.....|..
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 496-719 2.3e-51 169.7 In-house 8-227 (297) alignment 
Range on Protein: 496-719
Range on HMM: 8-227/297.0
KPIVLNKFEGHYgRMKADSDFRFTEEYDEirLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSprEFMACQGPLP
.|| | .|     . . ..|.   |  .   .  . |.   | . ||  |.|..|||||. |||||| . || | ||.|| ...|..   .... | | .
rpiplsdfatlv.qknrhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKiKCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPE--KTWT
 ||.|.|.|......|.||||... |. | ||  ||. |   .|.|.. | ......    . ||.....|.    | . ||.|..|||. |..  .. .
atvadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

MLDFVRTVREAIQKTASDrPIVAHCSAG
.|...  ||.  ...|.  |.. ||.||
llklisevrkdfsqnaeg.PllvhclaG
0050432 (Phosphotyrosine protein) phosphatases II 719-874 7.8e-51 168.6 In-house 146-301 (308) alignment 
Range on Protein: 719-874
Range on HMM: 146-301/308.0
GAIKCHEYWPAD--YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIqktaSDRPIVAHCSA
| .||..||| .   ....|| ..| .   ...|....|.. ..   ..| |..|..|...|||||||...  .|||.. ||. .    .. ||| ||||
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||||.|||| |.. ....  .|.|.... .|.||..||||. ||.|........|..
GvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 505-719 8.2e-51 168.0 In-house 12-231 (325) alignment 
Range on Protein: 505-719
Range on HMM: 12-231/325.0
GHYGRMKADSDFRFTEEYDEIRLVGkDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRM
 |  . ||. .  |. |.. .  ..  .|   |    |.||||| |......||| | .. ||...|||||.|.  .     |.|.| ||. |..|.||.
ehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

IWEKKTSIIVMLTQLvEKGKIKCHEYWPAD-YNPVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPEKTWTMLD---FVRT
. . ..|..|.| .| ..|| .|  ||| .  . .|.|...|........  .| | . . |    | | . |....||.| ||...  |..     | .
vldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka

VREAIQK-TASDRPIVAHCSAG
| | ..  | .  ||. |||||
vservtantkastpilvhcsaG
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 720-878 1.2e-50 167.4 In-house 130-289 (319) alignment 
Range on Protein: 720-878
Range on HMM: 130-289/319.0
AIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ-GDEI--RKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTaSDRPIVAHCSAGV
 .|...|||   |...|| . | ..  .. ....||.... .  .|.  |.........||||.||.|. ..||... .|.. .|| ...||| ||||||
kvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt.qsgPivvhCsaGv

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEE
|||||.|.||  .. ..|.  .|.| .. ..|.||| |||...||.||.| ... .  |. |
GRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
0051299 (Phosphotyrosine protein) phosphatases II 719-872 1.7e-50 167.4 In-house 130-286 (288) alignment 
Range on Protein: 719-872
Range on HMM: 130-286/288.0
GAIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHC
| .||. |||   ...||| |.|     ...|....|.. ..      ...| |. |..|...|||||||| .  .|||.| ||.|..  ... |.| ||
grekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHC

SAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
|||||||||.|||| |.. ....  .|...... .|.||..||||. ||.|..|.....|
saGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 719-874 2.4e-50 166.2 In-house 122-278 (281) alignment 
Range on Protein: 719-874
Range on HMM: 122-278/281.0
GAIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSI-SQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVG
| .||| ||| | . ..|| ..|. .| ..  ... |.|..  .. | |...| ....|||||||..|  .|.| . |... ... .. |.| |||||||
gklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl.tekktkaplvihCsaGvG

RTGTYIALDRLMQAM-QENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||||||||..|. .|.  .|.  .. |.| .|| ||||  || |..  |.| | .
rtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN23_pd Subfamily PTPN23 518-719 3.4e-50 165.5 In-house 23-222 (288) alignment 
Range on Protein: 518-719
Range on HMM: 23-222/288.0
FTEEYDEIRlvGKDQAIvsALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNS--PrEFMACQGPLPGTVDDMWRMIWEKKTSIIVM
  |....     ....|  |.  ..  |||...||||.|.||||     .|  ||||| .. .  .  | .|.| |.||..|. | |.|..|.|.|.|||
eleqkqdke..arkrsi..aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVm

LTQLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVRE--AIQKTASDR
|..  |.|| |...|||.|  ..|..| ..|...  .. ...| |.....  . |......  ...|||..|||.   |.|.|.  |..    ..  |. 
llskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt

PIVAHCSAG
|.| |||||
PlvvhCsaG
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 542-719 3.8e-50 165.3 In-house 3-182 (237) alignment 
Range on Protein: 542-719
Range on HMM: 3-182/237.0
NRAKNRFTNILPYEHSRVKLAALAddSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTY
|..|||. ||  |.|||| |      |..|||||.|. |.. .|....|.||||  . ||.|.|.|..| |.||||| |.|. ..|||.|||   .| .|
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAG
| . ||..  ...  . .| . .|.     |.| . ||.| ||||.|||..| ..| | . . .  .. .   | . |||||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsag
0039614 (Phosphotyrosine protein) phosphatases II 720-874 1.7e-49 164.3 In-house 140-291 (297) alignment 
Range on Protein: 720-874
Range on HMM: 140-291/297.0
AiKCHEYWPADYNpvTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRT
  ||..||| . .  ||| ..| .   ...|....|..... ..| |..|......|||||||. . ..|.|.. ||||.... ...|.. |||||||||
r.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||.||...... ....  .|.. ...|.|.||...|||. ||.|.......||.|
GtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0047943 (Phosphotyrosine protein) phosphatases II 719-871 5.4e-49 162.5 In-house 115-271 (273) alignment 
Range on Protein: 719-871
Range on HMM: 115-271/273.0
GAIKCHEYWPADYN--PVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSA
| .||. ||| . .  ..||| ..| .   ...|....|.. ..    .| |. |..|...|||||||. .  .|.|.. ||.|.... |. |.| ||||
grekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|||||||.|||| |.. ....  .|.. ... .|.|| .||||. ||.|..|.....
GvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0036941 (Phosphotyrosine protein) phosphatases II 719-875 8.3e-49 161.8 In-house 116-280 (297) alignment 
Range on Protein: 719-875
Range on HMM: 116-280/297.0
GAIKCHEYWPAD-YNPVTYGSIQVSVQALQQ--YDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCS
| .||..||| .  ...||| ..| ..  ..  .|....|.. ..   ..| |..|..|...|||||||. . ..|||.. ||...... |. |.. |||
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGVGRTGTYIALDRLMQAMQ---ENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
|||||.||.||.| ..| ..   ..  .||. .....|.||...|||. ||.|..|....||...
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0040438 (Phosphotyrosine protein) phosphatases II 720-879 1e-48 161.6 In-house 125-283 (317) alignment 
Range on Protein: 720-879
Range on HMM: 125-283/317.0
AIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVG
 .||..|||   ...||| ..| ..  ........|.. ..  ...| |..|..|...|||||||. . ..|||.. ||||..   .. |.. |||||||
rekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
||||.||...... ....  .|.. ...|.|.||...|||. ||.|........|.|..   
RtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle
subfamily_PTPN1_pd Subfamily PTPN1 516-719 2.2e-48 159.4 In-house 6-211 (290) alignment 
Range on Protein: 516-719
Range on HMM: 6-211/290.0
FRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVM
 ...| | .||   .|  . .| .  ||..||. .. ||.|||.||     ..|.|||||. .   .  |...  ||||| ||| .|.|.||.|.  .||
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTQLVEKGKIKCHEYWPADYN--PVTYGSIQVSV--QALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASD
| ..|||..|||..||| . .   ...  ....|   . ........| . . .   .| |.....|...||| ||||   ..|.|.  |||.   .   
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdv

RPIVAHCSAG
 | | |||||
GpavihcsaG
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 500-719 2.3e-48 159.5 In-house 4-226 (290) alignment 
Range on Protein: 500-719
Range on HMM: 4-226/290.0
LNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSD--TDYINANYIPGYNSPREFMACQGPLPGT
..||  .    .|  . .| ...  .    .....  .|   |. .|||.||..|.  |. |  .... |   .|||| || ||.  ....| |||.. |
vdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt

VDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVtYGSIQVSVQALQQYDHWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPEKTWTMLD
. | |..||..|..||||||. .|.|| ||. |||.  .   || ... ..  ..... ..|.... . ..    ...|||.. .|...|  ... |.| 
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

FVRTVREaIQKTASDRPIVAHCSAG
 .. . . .|.   ...|| |||..
vieemyk.tqrkrgntsivvHCSdt
0045450 (Phosphotyrosine protein) phosphatases II 720-873 6.3e-48 159.5 In-house 146-305 (307) alignment 
Range on Protein: 720-873
Range on HMM: 146-305/307.0
AIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGV
 .||..||| .  ..||| ..| .   ...|....| . ..   . .| |..|..|. .|||||||. . ..|||.. ||.|.... .. |.. ||||||
rekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGv

GRTGTYIALDRLMQAMQENDY---IDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|||||.||.. ... ....     .|.. .....|.|| ..||.. ||.|..|....||.
gRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0043336 (Phosphotyrosine protein) phosphatases II 720-872 1.2e-47 158.1 In-house 127-277 (278) alignment 
Range on Protein: 720-872
Range on HMM: 127-277/278.0
AIKCHEYWPadYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVG
 .||..|||   ...||| ..| ..  ...|....| . ..  . .| |. |.||...|||||||. . ..|||...||||..   |. |.. |||||||
rvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||.|||..|.. .. .  .|.. ...|.|.|| ..|||. ||.|..|.....|
RTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 722-877 4.1e-47 155.7 In-house 142-300 (330) alignment 
Range on Protein: 722-877
Range on HMM: 142-300/330.0
KCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS-QGDE-----IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASdrPIVAHCSAG
||. ||| .   |||| |.|.|.  .   .. .|.| .  ..|.      | ..|.|| |||| ||| ..  ||.... |..  |..|.  ||| |||||
kcaqywPde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEE
||||||.|.|| ... .. .  .|.|... ..|.|| .||||..|| ||.. ...    |. 
vGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 722-870 2.6e-46 153.4 In-house 139-289 (319) alignment 
Range on Protein: 722-870
Range on HMM: 139-289/319.0
KCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGR
|| .||| . . ....  .|.|..... . .|.|.. .|.     .|||.||.||. |||.|||| .  .. .|. ||   .|    ..|| ||||||||
kcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||.||.|| |.. |.|.. .|.. .. ..| |||..||   || ||.  ...
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 721-877 2.8e-46 153.1 In-house 139-295 (298) alignment 
Range on Protein: 721-877
Range on HMM: 139-295/298.0
IKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaIQKTASDRPIVAHCSAGVGR
.|.|.||| . .  |||.|.||... ...   ..|.. .|. .  . |.. | ||.||||.||| .. ..||..| ||   |. | ..|.. .|||||||
tkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgR

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEE
.||.||.| ... ....  .|.| ..  .|..| ..||||.||.||.| |.. |  ...
sGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 722-881 2.9e-46 153.0 In-house 130-292 (305) alignment 
Range on Protein: 722-881
Range on HMM: 130-292/305.0
KCHEYWPADYNP-VTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVG
||. |||   .  . .|...| ..  ...  ...|...||.    .| | ..||.. .|||||||... ..|.... |... ||   . |.. |||||||
kCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd.qkkdkgvpllVhCsagvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDTG
|||..||.|  .. ... . .|.|... ..| .|  |||| .|| |.|. . .|.  |. .  |
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiig
DSPc_SM00195 720-872 4.1e-46 152.8 In-house 108-262 (263) alignment 
Range on Protein: 720-872
Range on HMM: 108-262/263.0
AIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSAG
 .||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .||||||||.|  .|...|.|..  ...  . ||| |||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||||....| ... ..|.. .||| |..|.|.|| .||||..||.||.|......
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 720-872 4.1e-46 152.8 In-house 108-262 (263) alignment 
Range on Protein: 720-872
Range on HMM: 108-262/263.0
AIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSAG
 .||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .||||||||.|  .|...|.|..  ...  . ||| |||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||||....| ... ..|.. .||| |..|.|.|| .||||..||.||.|......
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN12_pd Subfamily PTPN12 721-874 5.9e-46 151.6 In-house 123-279 (290) alignment 
Range on Protein: 721-874
Range on HMM: 123-279/290.0
IKCHEYWPAD-YNPVTYGSIQVSVQALQQYD-HWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVGR
.||. |||    .....|...|.... .. |  ..|| . . . .| ||..|.|...||||||| .. ..|.....|||  .  ..| |.| ||||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGr

TGTYIALDRLMQAMQENDY---IDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||| ||.|   ......     .|.| .. |.| ||. .|||..|| .....|..|...
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 510-719 7.6e-46 151.4 In-house 14-221 (287) alignment 
Range on Protein: 510-719
Range on HMM: 14-221/287.0
MKADSDFRFTEEYDEIRLVGKDQA-IVSALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEK
 .| ..  |.. .  .  |....  .  ..   |. |||.|.||...  || |     . . ||||| .| ||.. ..|.....|.  |. ..|..|...
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddr

KTSIIVMLTQLVEKGKIKCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQGD---EIRKLTQYHFMSWPDHG-VPEKTWTMLDFVRTVREaiQ
. ..||||.|. |. . .|..||| . . |..|  ....   ........|.. . . .   . ....||.. .|...| |.|.   .| . . ...  |
nvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt..q

KTASDRPIVAHCSAG
.  .. .|| |||..
rkrgntsivvhCsdt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 722-870 9.8e-46 151.5 In-house 103-253 (284) alignment 
Range on Protein: 722-870
Range on HMM: 103-253/284.0
KCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGR
|| .||| . . ....  .|.|..... . .|.|.. .|.     .|||..|.||. |||.|||| .  .. .|. ||   .|    ..|| ||||||||
kcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||.||.|| |.. |.|.. .|.. .. ..| |||..||   || ||.  ...
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0045098 (Phosphotyrosine protein) phosphatases II 720-875 1.4e-45 151.2 In-house 103-275 (278) alignment 
Range on Protein: 720-875
Range on HMM: 103-275/278.0
AIKCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPDKT--WTMLDFVRTVREAIQ-----------
 .||..||| . ...||| ..| ..  ...|....| . .       ...| |..|..|...|||||||. .  . .|.... .|||..           
rekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

KTASDRPIVAHCSAGVGRTGTYIALDRLMQAMqeNDYIDIFGIICEMRMQRNH-MVQTEKQYIFIHECVMDLLRRG
   |. |.. |||||||||||..|.. ... .  .. .|.. ...|.|.||.. .||.. ||.|..|....||.||
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0042113 (Phosphotyrosine protein) phosphatases II 720-872 1.5e-45 150.9 In-house 91-243 (245) alignment 
Range on Protein: 720-872
Range on HMM: 91-243/245.0
AIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtASDRPIVAHCSAGVG
 .||..|||   ...||| ..| .   ...|....|.....  . || |. ..||...|||||||| . ..|||.. ||.|...  |. |.. |||||||
rvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||.||...... ....  .... .. |.|.|| ..|||. ||.|..|....||
RtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 538-720 3.2e-45 149.2 In-house 4-185 (239) alignment 
Range on Protein: 538-720
Range on HMM: 4-185/239.0
LEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYn
 . ||.||||..||. |.|||| |  |..|  .|||||.|.  |. ||. ..| || .  .  |.|||.|...  .||||| |.|  | |||.|||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

pVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGA
   |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | ||||| 
.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 539-719 4.4e-45 148.7 In-house 4-183 (239) alignment 
Range on Protein: 539-719
Range on HMM: 4-183/239.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYnp
. ||.||||..||. |.|||| |  |..|  .|||||.|.  |. ||. ..| || .  .  |.|||.|...  .||||| |.|  | |||.|||     
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..

VTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHCSAG
  |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | |||||
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsag
0040439 (Phosphotyrosine protein) phosphatases II 720-873 7.3e-45 148.9 In-house 93-247 (249) alignment 
Range on Protein: 720-873
Range on HMM: 93-247/249.0
AIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVG
 .||..|||   ....|| ..| .   ...|....|.. ..  . .| |. ..... .|||||||. . ..|||.. ||.|.... .. |.. |||||||
rekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
||||.||.. ... ....  .|.. .....|.||...||.. ||.|..|....||.
RtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
Y_phosphatase Protein-tyrosine phosphatase 721-869 1.3e-44 147.7 Pfam-A 82-234 (235) alignment 
Range on Protein: 721-869
Range on HMM: 82-234/235.0
IKCHEYWP-ADYNPVTYGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIqkTASDRPIVAHCSA
 ||..||| .. ...|||.|.| ..   . . .....|...... .|    |...|.|. .|||||||...  .||..| |..    .|.. |.| ||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
|||||||..||| |.. ..... .|.. |..|.| ||..|||...||||......
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 721-869 1.3e-44 147.7 In-house 82-234 (235) alignment 
Range on Protein: 721-869
Range on HMM: 82-234/235.0
IKCHEYWP-ADYNPVTYGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIqkTASDRPIVAHCSA
 ||..||| .. ...|||.|.| ..   . . .....|...... .|    |...|.|. .|||||||...  .||..| |..    .|.. |.| ||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
|||||||..||| |.. ..... .|.. |..|.| ||..|||...||||......
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN14_pd Subfamily PTPN14 519-720 1.4e-44 147.4 In-house 26-240 (300) alignment 
Range on Protein: 519-720
Range on HMM: 26-240/300.0
TEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDsDTDYINANYIPGY--NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
  ||..|    .|  . .|   .|  |||| ..||||..||.|..  .. .|.||||  |      . |.....||||. || |.|.|.||.....||||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TQLVEKGKIKCHEYWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDR-
|.  |.|| |...|.| .    . |..|  .|. .  .. |  . . . .      | |..    .. ||||||||   ..|.... |.   .|| | . 
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

------PIVAHCSAGA
      |.. |||||.
skeskPPvlvhCsaGv
0037934 (Phosphotyrosine protein) phosphatases II 719-871 4.1e-44 146.3 In-house 86-241 (243) alignment 
Range on Protein: 719-871
Range on HMM: 86-241/243.0
GAIKCHEYWPadyNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQK------TASDRPIV
|..||..|||   ..|||| ..| .   ...|....|.....    .|. |  ..||...|||||||| .  .|||.. ||| |..        |..|..
grekcaqywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

AHCSAGVGRTGTYIALDRLMQAMqenDyIDIFGIICEMRMQRNH-MVQTEKQYIFIHECVMDL
 |||||||||||.||.. ... .   . .|.. .....|.||.. .|||. ||.|..|... |
VHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN6_pd Subfamily PTPN6 721-874 5e-44 145.5 In-house 138-299 (306) alignment 
Range on Protein: 721-874
Range on HMM: 138-299/306.0
IKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTA--SDRPIVAHCSAG
 ||  |||.  .  .||.|.|.  . .. .....||.|.|   ...| |.. |||| |||||||| .. ..|||...|..  ....  . .||| |||||
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VGRTGTYIALDRLMQAMQEND---YIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
.|||||.| .| |.. ....     |||  ..  .| ||. .||||.|| |... .   ...
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 502-720 1.9e-43 143.5 In-house 6-223 (439) alignment 
Range on Protein: 502-720
Range on HMM: 6-223/439.0
KFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALE--MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVD
.|. |  ... . .  |.|....|  .  | | ...|     ...|||. .. ...|.|| |  .     . ||||||| ||  .. ..|.|||   |.|
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DMWRMIWEKKTSIIVMLTQLVEKGKikcheYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSIS----QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDF
|.||...||||. |||||.|||  |     |||.| . | || | | |.   .  ..||| | .     ...  | . |.|...|||. || ..  .|||
dfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

VRTVREAIQKTASdRPIVAHCSAGA
.|..  | .|     |.| ||||| 
lrainsandkeey.gpvvvhcsagv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 722-872 2e-43 143.4 In-house 92-242 (250) alignment 
Range on Protein: 722-872
Range on HMM: 92-242/250.0
KCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRK--LTQYHFMSWPDHGVPDKTWTMLDFVRTVReAIQKTASDRPIVAHCSAGVGRT
..|.|||.. .. .||...||.   ...  ...|.. .|.  .  .  . |.||..||| |||... ..|.... |. | |. | ..|.. .|||||||.
tyhqywPve.kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq.asqqqagnaPvivqCsaGvgrs

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
|..||.| ... ....  .|.| .|  .| .| |.|....||.|..| ..  |
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 722-873 2.1e-43 143.4 In-house 114-269 (274) alignment 
Range on Protein: 722-873
Range on HMM: 114-269/274.0
KCHEYWPADYNP---VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASD-RPIVAHCSAGVG
||..|.| . .     .|| ... |.   . ... .|......  . |... | . .|||| .||.. |.||.|. |.|. ....    |.| |||||.|
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
||| .|| .  .. ..|.  .|...|.|..|..|  ||||..|| .||. ..  |.
rtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 719-871 4.4e-43 142.2 In-house 122-274 (280) alignment 
Range on Protein: 719-871
Range on HMM: 122-274/280.0
GAIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGV
| .|||.|||   . ..||...| ..  ..   .|.||. ... .  | ||..|  ...||||||||..  .|.||..||..  ......|.| |||||.
GrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePvvvhCsaGi

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|||| .|.|.  .. ..... . .  |. .|| ||  .|||..|| |. |... .
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 536-720 8.5e-43 141.2 In-house 32-221 (287) alignment 
Range on Protein: 536-720
Range on HMM: 32-221/287.0
SALEMVNRAKNRFTNILPYEHSRVKLAALAdDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY
.| |. .  |||....||....|| |.| . .  .|||||||...|.   .|.|.|||.. || |.||...|.... ....|. ||... ||..|||   
aaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

NPVTYGSIQVSV--QALQQYDhWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVR---EAIQKTASDRPIVAHCSAGA
 |.  |   | .  .  .. . . .| . . .  . | | . |....||||....  .  .. ||  |.   |. ....   |.| |...|.
vPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi
subfamily_PTPRG_pd Subfamily PTPRG 721-882 9e-43 141.3 In-house 131-297 (563) alignment 
Range on Protein: 721-882
Range on HMM: 131-297/563.0
IKCHEYWPAdYNPVTYGSIQVSVQALQQYD-----HWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHC
 ||. |||.  ...|||..||  .. ..       . ||... . ....    .. .|||. .|||||||...   | ||.    |  . |   ||| ||
rkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa..nkaeaGPivvHc

SAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDTGE
|||||||||||.|| |.. .|... ...||..  .|.|||..|||| ||||.|. ...... .|.| . |
saGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 721-872 1e-41 137.6 In-house 126-276 (515) alignment 
Range on Protein: 721-872
Range on HMM: 126-276/515.0
IKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTAsdRPIVAHCSAGVGRT
||| .|||    . | .|||.|.. .|.     ..|.. . .||..| .||.||  |||.||| .| ..| ... |.   .. .   |.. |||||||||
ikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
| .|..|  .  ... . .|.| ..  .| .| ..|||. || ||.. |.. |
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 518-720 1.6e-41 137.0 In-house 22-180 (392) alignment 
Range on Protein: 518-720
Range on HMM: 22-180/392.0
FTEEYDEIRLVGKDQAiVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
|.||. ..      .   .| . .|  |||. |||||. .||||  . | .|.||.|| |||.... . ..|.||| . ..||.|||....... |.|.|
ffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

QLVEKGkikcheywpadynpvtygsiqvsvqalqqydhwvirefsisQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaIQKTASDRPIVAHCS
.| |                                           .||. |  .|.||  |||..||..| ..| |.. |.  ..     .|.. |||
klkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevk..adfGqythpliihcs

AGA
|| 
agv
subfamily_Ptp69D_pd Subfamily Ptp69D 722-877 2.8e-41 136.6 In-house 132-291 (307) alignment 
Range on Protein: 722-877
Range on HMM: 132-291/307.0
KCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD-------EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSA
||. ||| . . | ||.| | .   .. ....|||...|. .       . ||..|||...|.|  ||. . ..|.... |||  ..     ||| ||||
kcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEE
||||.|...||| |.| ....| .||| .....| ||| .||  .||.|..  ..|    |. 
GvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 722-876 8e-41 135.0 In-house 133-283 (315) alignment 
Range on Protein: 722-876
Range on HMM: 133-283/315.0
KCHEYWPADynPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiQKTASDRPIVAHCSAGVGRTGT
|. .||| .   |.|| | |. .  ...... .| .|.  ||.||.. |.|. |||| |||  | ......|||.    .|.|  .|| |||||||||||
kaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkq..hhtnsvgaivvhcsaGvGrtGt

YIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGE
.|.|| ... .. .. ||.. .|  .| .| .|||. .|| ||.. ... .  |.
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd
subfamily_PTPN13_pd Subfamily PTPN13 719-873 9.2e-41 134.9 In-house 115-270 (273) alignment 
Range on Protein: 719-873
Range on HMM: 115-270/273.0
GAIKCHEYWPADYN-PVTY-GSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaIQKtaSDRPIVAHCSA
| .||| |||   | ...  . ..|..  .|..| .|.|.. ..  .  | |.... .|..||||||| ..  .| ||. ||. .|.  .  ||| ||||
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqt..dagPivvhcsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|.||.||.|..| ... .. .  .|.  |. ..| ||. .|||..||||... ....|.
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPRN_pd Subfamily PTPRN 536-720 1.1e-40 134.2 In-house 50-235 (297) alignment 
Range on Protein: 536-720
Range on HMM: 50-235/297.0
SALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYnSPRE--FMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPA
 | .  |  ||| ...|||.|||||| . |.....|||||  |     ||.  ..|.||||. || |.|.|.||. . .||.||.| |.|  .|..||| 
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildh.dprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

DYNPVtYGSIQVSVQAL-QQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASdrPIVAHCSAGA
. . | |.  .| . .     | ...| | .   | .| | .||.||.|||..||| .. ..|.| | |  . .  ..  ||| |||.||
eGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrsc..pivvhcsdGa
subfamily_PTPRK_pd Subfamily PTPRK 720-871 1.5e-40 133.9 In-house 125-276 (314) alignment 
Range on Protein: 720-871
Range on HMM: 125-276/314.0
AIKCHEYWPADYNPvtYGSIQVSVQALQQYDHWVIREFSISQ----GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtaSDRPIVAHCSAG
..|| .||| | .   || |.| .   .     |.| |....     .|||.. |..|..||||.|| .  ..|..|| | .  ..  .. .|| |||||
rvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 |||||.||.| ... ..... .|.| .. ..| ..  ||.||.||.||.. ... 
aGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_ptpA1_pd Subfamily ptpA1 540-722 2.4e-40 133.5 In-house 45-242 (418) alignment 
Range on Protein: 540-722
Range on HMM: 45-242/418.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGyNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP--
  | .|||.||||| .|.||.|  . |   .|||||||| |   |..|.. ||||| |. |.|||.||..  |||||..  |. .|||  ||| .     
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

--------VTYGSIQVS-VQALQQYDHWV-IREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTV--REAIQKTASDR--PIVAHCSAGAIK
          .|.  |  |. .|. .. .  |.  ..   | | .|||..  |||| .|..|  . ......  |.     .|||  ||. |||||  .
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 721-873 3.6e-40 132.7 In-house 127-278 (315) alignment 
Range on Protein: 721-873
Range on HMM: 127-278/315.0
IKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRT
|||  |||  . . | .|||.|..  |..    |.|.. . ...| |..||..|  |||.||. .| ..| ... |.    .   . ... |||||||||
ikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|  |..|  .. ..... .|.| .. ..| .| ..||||..| ||.. |.. | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 722-874 9.6e-39 128.3 In-house 132-286 (297) alignment 
Range on Protein: 722-874
Range on HMM: 132-286/297.0
KCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPD--KTWTMLDFVRTVREAIQKTASDrPIVAHCSAGVG
||  ||. |   .|.|.. | ......    . ||.....|.    | . ||.|..|||. |.   .. ..|...  ||.  ...|.  |.. ||.||||
kcaryWs.dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||| ....|  .  ..... .||||..  .| .| ..|||..|| |... |.. |  
rtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPN9_pd Subfamily PTPN9 719-871 1.8e-38 127.3 In-house 123-289 (297) alignment 
Range on Protein: 719-871
Range on HMM: 123-289/297.0
GAIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQ-----------KTAS
| .|| .|||  . .   .|...||.   ........| . |.  . .|.||.| . |.||||.|||. . ..||....|||.               .|
grlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps

DRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
. ||| |||||.|||||.|.||  .. ..| . .|..  .  .| || ...||..|| | . .|.. 
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_CG7180_pd Subfamily CG7180 537-720 4.5e-38 125.6 In-house 37-234 (296) alignment 
Range on Protein: 537-720
Range on HMM: 37-234/296.0
ALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKiKCHEYWPADYn
.|.  || |||  ...||.. || |  |  ....||||| |. ..  ..|..  ..|   |||. ||.......| .|.||.  .  | ....||| .  
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

PVTYGSIQVSVQALQQYDHWVIREFSISQG------------DEIRKLTQYHFMSWPD-HGVPEKTWTMLDFVRTVREAIQKT---ASDRPIVAHCSAGA
   || | | .   .|| . .||.| . .              | | ......  |.  . ||  | ......| ||  ..|.       |.| ..| ||
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa
0051429 (Phosphotyrosine protein) phosphatases II 720-873 1.3e-37 125.3 In-house 60-226 (272) alignment 
Range on Protein: 720-873
Range on HMM: 60-226/272.0
AIKCHEYWP-----------ADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPDKTwtMLDFVRTVREaiqktasD
. ||. |||            .. ...|| . | ..  ........||. ..   . .|.|.....|...|||||||...  .|.... ...       .
rlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......g

RPIVAHCSAGVGRTGTYIALDRLMQAMQENDYID--------IFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
.|.. |||||..||||..||..|.. . ... .|        ..... |.| || ..|||| ||.|..|....|||
gpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 517-719 1.4e-37 124.1 In-house 16-236 (301) alignment 
Range on Protein: 517-719
Range on HMM: 16-236/301.0
RFTEEYDEIRLVGKDQAIVSALEmVNRAKNRFTNILPYEHSRVKLAAL--ADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIV
.| |.|.|.. . .....|.  |  |.| ||| || .|.. |. |.     | . ..||||.|| ||.. ..|.| |||.  |. |.||.||..|.. ||
kfeeqykelkegedksctvglse.enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTQLVEKGKIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSI-----------------SQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFV
|.|.| |. | ||..|||  . .  ..| ..| ..  | |  .|||....                 ..  . ....|..  .||..||     |.|  .
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

RTVREAIQKTaSDRPIVAHCSAG
  |  . ||  .  |.| |||..
ddvihrqqki.gggpvvVHCSdt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 722-888 4.2e-37 123.0 In-house 131-304 (325) alignment 
Range on Protein: 722-888
Range on HMM: 131-304/325.0
KCHEYWPAD-YNPVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPDKTWTMLD---FVRTVREAIQK-TASDRPIVAHCSA
.|  ||| .  . .|.|...|........  .| | . . |    | | . |....||.| ||. .  |..     | .| | ..  | .  ||. ||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDTGESIYVNL
||||||..|.|  ... . |.  .|||| .  .| .|  ||.|  |||.|.|.... .  |. .    |.  .|
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 721-871 1.1e-36 121.3 In-house 104-263 (270) alignment 
Range on Protein: 721-871
Range on HMM: 104-263/270.0
IKCHEYWPADYNP---VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTW------TMLDFVRTVREAIQKTASDRPIVAH
 ||  ||||. .    ...| |.| ... .. . .....  . .  |.|.|. ... .||||||| ..        .|  .|.||.  ....   |.. |
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|||||||||| ||||  .....|.  .|.  || |.| .|  .||. .|| |... |.  
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
PTPc_DSPc_SM00012 768-869 1.9e-36 119.8 In-house 2-104 (105) alignment 
Range on Protein: 768-869
Range on HMM: 2-104/105.0
LTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQEN-DYIDIFGIICEMRMQRNHMVQTEKQYIFIHE
...||...|||||||...  .|...| |..  .| .|  |.| |||||||||||..||| |.| .... . .||| |..|.|.||..||||| ||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVM
...
all
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 520-719 3e-36 119.8 In-house 13-209 (283) alignment 
Range on Protein: 520-719
Range on HMM: 13-209/283.0
EEYDEIRLVGKDQAIVSAleMVNRAKNRFTNILPYEHSRVKLAALADdsdtDYINANYIP---GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
| .... .  .|  | ||    |. |||. .|.|..  ||.| ...     ||||| .||    |.  ......|.||  || |.|.|....| . ||||
evlkrlsvpdldadiasa..denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVreAIQKTASDRPIV
|.| |  .|||  ||| .   . ||   |...     . ..|.|. . .     .   |. | .  | . |      ... | . .  . |.   . |||
tklqedlrikCsqyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvi..slqteskkgPiv

AHCSAG
 |||.|
vhCstg
0041856 (Phosphotyrosine protein) phosphatases II 542-719 3.1e-36 120.0 In-house 1-119 (182) alignment 
Range on Protein: 542-719
Range on HMM: 1-119/182.0
NRAKNRFTNILPYEHSRvklaaladdsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTqlvekgkikCHEYWPadynpvtyg
|. |||...||||.|||          | ||||||.. |.  ...| |.||||..|| |..||..| . ..||.||         .. |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

siqvsvqalqqydhwvirefsisqGDEIRKLTQYHFMSWPDHGVPEkTWTMLDFVRTVREaiqktaSDRPIVAHCSAG
                         .. |  .||....|||||||. . ..|||...|.|      ...|.. |||||
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaG
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 530-692 9e-36 118.2 In-house 21-186 (297) alignment 
Range on Protein: 530-692
Range on HMM: 21-186/297.0
KDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALAddSDTDYINANYI--PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKC
. ..  ||       |||...|| .. .||||      ...|||||.|.  |  ...  ..  ||||  |||| |....|.   .|||...| | |. ||
rgesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

HEYWPA-DYNPVTYGSIQVS--VQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTM
  |||  . .  . |.. |    .  ...|. .. |. .   .| |...   |.||||||||     .
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledl
0051429 (Phosphotyrosine protein) phosphatases II 570-719 4.3e-35 117.0 In-house 4-160 (272) alignment 
Range on Protein: 570-719
Range on HMM: 4-160/272.0
TDYINANYIPGYNS---PREFMACQGPLPGTVDDMWRMiWEKKTSIIVMLTQLVEKGKIKCHEYWP-----------ADYNPVTYGSIQVSVQALQQYDH
..||||....||..   |. . ...|||| |..| ||. .| . . ||.|....|.|. ||. |||            .. ...|| . | ..  .....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

WVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPEKTwtMLDFVRTVREaiqktasDRPIVAHCSAG
...||. ..   . .|.|.....|...|||||||...  .|.... ...       ..|.. |||||
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaG
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 721-869 6.8e-35 115.4 In-house 85-236 (237) alignment 
Range on Protein: 721-869
Range on HMM: 85-236/237.0
IKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVG
.|||.|||   .| .|| . ||..  ...  . .| . .|.     |.| . ||.| ||||.|||..| ..| | . . .  .. .   | . |||||||
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
||| .. .| ...  .|.  .||.  .  .  .| ...||. ||.|||. ..
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 719-874 1.4e-34 114.3 In-house 129-285 (290) alignment 
Range on Protein: 719-874
Range on HMM: 129-285/290.0
GAIKCHEYWPADYNPVtYGSIQVSVQALQQYDHWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaIQKTASDRPIVAHCSAG
|  ||. |||.  .   || ... ..  ..... ..|.... . ..    ...|||.. .|...|   .. |.|  .. . . .|.   ...|| |||..
gkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk.tqrkrgntsivvHCSdt

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||.....|..  .. .. .  ||.| .. ..|.|.  .|||..|| .|.. |.  | .
vgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 722-875 3.9e-34 112.8 In-house 127-282 (439) alignment 
Range on Protein: 722-875
Range on HMM: 127-282/439.0
KCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSIS----QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASdRPIVAHCSAGVG
. . |||.| . | || | | |.   .  ..||| | .     ...  | . |.|...|||. || ..  .|||.|..  | .|     |.| |||||||
esykywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey.gpvvvhcsagvG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
|||| ||||  .. .. .. .|| ||.  .| ||..|||.  ||.||...|.. .  |
rtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyG
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 721-874 7.6e-34 112.0 In-house 126-280 (287) alignment 
Range on Protein: 721-874
Range on HMM: 126-280/287.0
IKCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQGD---EIRKLTQYHFMSWPDHG-VPDKTWTMLDFVRTVREaiQKTASDRPIVAHCSAGV
 .|..||| . . |..|  ....   ........|.. . . .   . ....||.. .|...| |...   .| . . ...  |.  .. .|| |||..|
evcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt..qrkrgntsivvhCsdtv

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||.....| .  ..  ...  ||.| .. ..|.|. ..||| .||.|| . |.  |  
GrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 722-870 7.8e-33 108.6 In-house 92-238 (239) alignment 
Range on Protein: 722-870
Range on HMM: 92-238/239.0
KCHEYWPADYnpVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRT
|||.|||       |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | |||||||||
kchqywpdst..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
|... .| ...  ...  .|||  .  .| .| ||||| .||.||| .|..
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 544-719 9.2e-33 108.1 In-house 58-226 (290) alignment 
Range on Protein: 544-719
Range on HMM: 58-226/290.0
AKNRFTNILPYEHSRVklaALADDSDTDYINANYIPGYNSPreFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-NPVTYGS
 |||. ..   . .||    | |  | ||. |||. | ...  |.  ||.|  || |.|||. ..|.. |||| .|.|.|| ||..|.|    . .|.|.
kknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

IQVSVQALQQYDHWV-IREFSISQGDE--IRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqktasDRPIVAHCSAG
| |     .. |  .  . .|. . |.    ||  .. .||||. |.  | ..|  .|..|.|        |.| |||||
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaG
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 722-869 9.7e-33 108.3 In-house 93-238 (239) alignment 
Range on Protein: 722-869
Range on HMM: 93-238/239.0
KCHEYWPADYnpVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRT
|||.|||       |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | |||||||||
kchqywpdst..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
|... .| ...  ...  .|||  .  .| .| ||||| .||.||| .|.
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN23_pd Subfamily PTPN23 721-874 1.6e-32 107.5 In-house 123-282 (288) alignment 
Range on Protein: 721-874
Range on HMM: 123-282/288.0
IKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVRE--AIQKTASDRPIVAHCSAG
 |...|||.|  ..|..| ..|...  .. ...| |.....  . |......  ...|||..|||.   |.|.|.  |..    ..  |. |.| |||||
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaG

VGRTGTYIALDRLMQAMQEN-DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||..  .   .......   .||  ..  .| || .|||...|. |  | |.   ||
vgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 539-720 6e-32 105.4 In-house 34-211 (281) alignment 
Range on Protein: 539-720
Range on HMM: 34-211/281.0
EMVNRAKNRFTNILPYEHSRVKLAA-LADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-N
. ||  |||..||   . |||.|   . .   |||| ||||      | ..  |||   |  |.|||||...|. |||| |..|  . || ||.| .   
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

PVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAGA
 . .  . || .        |   . .|   | | .|.. .  |||  ||| .  ||  .| .|      |   | | ||||| 
clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir......arstppvihcsagv
0036282 (Phosphotyrosine protein) phosphatases II 722-866 7.7e-32 105.8 In-house 53-164 (174) alignment 
Range on Protein: 722-866
Range on HMM: 53-164/174.0
KCHEYWPAdynpvtygsiqvsvqalqqydhwvirefsiSQGDEIRKLTQYHFMSWPDHGVPDKTWtMLDFVRTVREAIQKtASDRPIVAHCSAGVGRTGT
||. |||                                . |. |   ||... |||||||| .  .|.||. |.||...  ...|.. |||||||||||
kcinywpe..............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGt

YIALDRLMQAMQeNDYIDIFGIICEMRMQRNHMVQTEKQYIFIHE
 .|...... .  ....|.. .. |.|.|| .||||. ||.|...
lvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_CG42327_pd Subfamily CG42327 533-704 7.8e-32 105.2 In-house 17-195 (319) alignment 
Range on Protein: 533-704
Range on HMM: 17-195/319.0
AIVS--ALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHE
 | .  .. .  . |.|. |..|  ..|| |   .||  . |..|.|. ||. .|  ..|.| .|  .  |.||..||... .|| ||.| |.|  .| |
liaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcae

YWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFmSWPDHGVPEKTWTMLDFVRTVREAIQ
|.|.     |  .|| |.|...  .  |...|  . .   ...| |.|| | .  |.. .|| .  ...  .  ||....
ylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
0049772 (Phosphotyrosine protein) phosphatases II 532-719 3.8e-31 104.4 In-house 36-222 (314) alignment 
Range on Protein: 532-719
Range on HMM: 36-222/314.0
QAIVSALEMVNRAKNRFTNILPYEhSRVKLaALADDSDTDYINANYIPGYnspREFMACQGPLPGTVDDM----------WRMI--WEKKTSIIVM----
. |. |   .|| |||...|||.. .||.|    . |..|||||.|. |.   . |.|.||||. ||.|           |||.  .. .. .|||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTQLVEKGkikcHEYWPADYNPVTygsiqvsvqalqqydhwvirefSIS--QGDEIRKLTQYHFMSWPDHGVPeKTWTMLDFV
                 |..| ..|     |...||.                          ..   . .  |   .|. . .||...|  .  ...|.
vladelsrLdaAlgKtpllildgng....neptaadlellk......................eelydpelferlgikylripvpDgsap.lledfdefl

RTVREAiqktASDRPIVAHCSAG
. ..||      ..|.. ||.||
efieea....dkggpvlvHCkaG
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 524-719 3.6e-30 100.0 In-house 21-219 (307) alignment 
Range on Protein: 524-719
Range on HMM: 21-219/307.0
EIRLVGK---DQAIVSALEmVNRAKNRFTNILPYEHSRVKLAalADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLV
|.| . |   .   | |..  |  |||....   ...|. .    |   .||| |||.     |. |...||||  |. ..| |. ..|   ..|| ...
efrvlakktpegvtveafs.antdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EKGKIKCHEYWPADY-NPVTYGSIQ--VSVQ-----ALQQYDHW-VIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaiqktaSDRP
| .||||..|||..  .  ..|.    .||.      |   ..   . .. .  ... | .... .  |||.|||.   | .... .||          |
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnp

IVAHCSAG
.| |||||
vvvhcsaG
subfamily_PTPRN_pd Subfamily PTPRN 720-870 4.1e-30 99.5 In-house 139-290 (297) alignment 
Range on Protein: 720-870
Range on HMM: 139-290/297.0
AIKCHEYWPADYNPVtYGSIQVSVQAL-QQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASdrPIVAHCSAGV
  .|..||| . . | |.  .| . .     | ...| | .   | .| | .||.||.|||..||| .. ..|.| | |  . .  ..  ||| |||.|.
vkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrsc..pivvhcsdGa

GRTGTYIALDRLMQAMQE-NDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||||.||..| ... ..     |||   .  .| ||...|.|..|. |.  .| .
GrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0036282 (Phosphotyrosine protein) phosphatases II 570-719 7.8e-30 99.2 In-house 2-114 (174) alignment 
Range on Protein: 570-719
Range on HMM: 2-114/174.0
TDYINANYIPGYNSPREFMACQGPLPgtvddMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdynpvtygsiqvsvqalqqydhwvirefsiSQGDEI
.|||||... ..  .... |.||||.      |.|..| . ...|||....|.|. ||. |||                                . |. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RKLTQYHFMSWPDHGVPEKTWtMLDFVRTVREAIQKtASDRPIVAHCSAG
|   ||... |||||||. .  .|.||. |.||...  ...|.. |||||
rlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaG
subfamily_PTPN14_pd Subfamily PTPN14 719-874 1.7e-29 97.8 In-house 131-298 (300) alignment 
Range on Protein: 719-874
Range on HMM: 131-298/300.0
GAIKCHEYWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDR-------
|  |...|.| .    . |..|  .|. .  .. |  . . . .      | |..    .. |||||||.   ..|.... |.   .|| | .       
gkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

PIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|.. ||||||||||  |  | |..... |. |||  ..  .| || ..|||  || |... ..  |..
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0048076 (Phosphotyrosine protein) phosphatases II 741-871 1.8e-29 97.7 In-house 20-142 (145) alignment 
Range on Protein: 741-871
Range on HMM: 20-142/145.0
VSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtasDRPIVAHCSAGVGRTGTYIALDRLMQamqeNDyIDI
.... |...... .  ..  . .. |. .||....|||||||| . ..|.|.. ..||...   ..|.. |||||||||||..|.. ...    .. ...
ldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsl

FGIICEMRMQRNHMVQTEKQYIFIHECVMDL
. .. ..|.|| ..|... |..|..|... |
eealelvrsqrpgavpnpgqlrflyefelel
0041856 (Phosphotyrosine protein) phosphatases II 723-874 2.3e-29 97.7 In-house 67-173 (182) alignment 
Range on Protein: 723-874
Range on HMM: 67-173/182.0
CHEYWPadynpvtygsiqvsvqalqqydhwvirefsisqGDEIRKLTQYHFMSWPDHGVPDkTWTMLDFVRTVREaiqktaSDRPIVAHCSAGVGRTGTY
.. |||                                  .. |  .||....|||||||| . ..|||...|.|      ...|.. |||||||||||.
eelywp.................................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtl

IALDrLMQAMqenDyIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
.|.. ||  .   . .... .....|..|..||.|. ||.|.. ....||..
vaay.lmkkl...g.vsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_PTPN1_pd Subfamily PTPN1 720-870 2.5e-29 96.9 In-house 110-269 (290) alignment 
Range on Protein: 720-870
Range on HMM: 110-269/290.0
AIKCHEYWPADYN--PVTYGSIQVSV--QALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCS
 |||..||| . .   ...  ....|   . ........| . . .   .| |.....|...||| |||.   ..|.|.  |||.   .    | | |||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGVGRTGTYIALDRLMQAMQENDY---IDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||.||.||.. .| ..  ....|    .||   ..|.| .|  ..|| .|  | .  ...
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0046846 (Phosphotyrosine protein) phosphatases II 565-719 3.7e-28 93.9 In-house 7-119 (176) alignment 
Range on Protein: 565-719
Range on HMM: 7-119/176.0
ADDSDTDYINANYIPGYnsprEFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTygsiqvsvqalqqydhwvirefsis
 .| | ||||||.| |.     . |.|||||.|. | ..|..| . ...|.||..||.|..||. |||  ...                           
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

qgdeirkltQYHFMSWPDHGVPEKtWTMLDFVRTVREAIQKTasdRPIVAHCSAG
         ||... |||||||.    .|.... .|||...    .|.. |||||
.........qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaG
0043147 (Phosphotyrosine protein) phosphatases II 567-719 4.3e-28 93.6 In-house 2-110 (172) alignment 
Range on Protein: 567-719
Range on HMM: 2-110/172.0
DSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLvekgkikcheywpadynpvtygsiqvsvqalqqydhwvirefSISQG
|...|||||.|...|  |..| |.||||. |..| |||..|.. ..||.||.|                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

DEIRKLTQYHFMSWPDHGVPeKTWTMLDFVRTVREAIqKTASDRPIVAHCSAG
.. |   ||....|||||||  .  .|.|.. ..|..    .. |.. |||||
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaG
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 758-876 9e-28 91.8 In-house 81-198 (440) alignment 
Range on Protein: 758-876
Range on HMM: 81-198/440.0
SISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQT
|  .| | | | |||. .|||.|||  .  .| ... | |. |. |.. |.. |||||.||||  ||.| ...  . .| |||| .|  || .| .||||
syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

EKQYIFIHECVMDLLRRGE
 .|| |.||.|.. |  |.
peqyafvheavlegllcgd
0046846 (Phosphotyrosine protein) phosphatases II 722-872 1.2e-27 92.2 In-house 64-173 (176) alignment 
Range on Protein: 722-872
Range on HMM: 64-173/176.0
KCHEYWPADYNPVTygsiqvsvqalqqydhwvirefsisqgdeirkltQYHFMSWPDHGVPDKtWTMLDFVRTVREAIQKTasdRPIVAHCSAGVGRTGT
||. |||  ...                                    ||... ||||||||    .|.... .|||...    .|.. |||||.|||||
kcpnywpeleklgi..................................qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgt

YIALDrlmqAMQENDYIDIFGIICEMRMQRN-HMVQTEKQYIFIHECVMDLL
..|..     .. .  .... .....|.||  ..|||..|| |..|... ||
lvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 762-867 1.6e-27 91.7 In-house 59-156 (172) alignment 
Range on Protein: 762-867
Range on HMM: 59-156/172.0
GDEIRKLTQYHFMSWPDHGVPdKTWTMLDFVRTVREAIqKTASDRPIVAHCSAGVGRTGTYIALDRLMqamqenDYIDIFGIICEMRMQRNHMVQTEKQY
 .. |   ||....|||||||  .  .|.|.. ..|..    .. |.. ||||||||||| .|.. ..        .... .....|..|...||.. ||
ellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIHEC
.|....
rflyyf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 746-872 1.9e-27 90.7 In-house 122-237 (392) alignment 
Range on Protein: 746-872
Range on HMM: 122-237/392.0
LQQYDhwvirefsisQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIIC
|.. |          .||. |  .|.||  |||..|| .| ..| |.. |.  ..     .|.. ||||||||||  |..| ..   ..   .|.| .. 
lkegd..........kgddartvaqfhftewPdkdvpkhtssllkfikevk..adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvt

EMRMQRNHMVQTEKQYIFIHECVMD-LL
..| .| .||||..|| ||. .|.. ||
nirrkrpymvqtkeqyafiygavledll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 539-720 2.4e-27 90.5 In-house 45-230 (305) alignment 
Range on Protein: 539-720
Range on HMM: 45-230/305.0
EMVNRAKNRFTNILPYEHSRVKLaalADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPV
|  .. |||. ..   .. ||||         .|| |||.     |. |. .| ||  |  |.| | ...|   | || .|.|||  ||.||.... ..|
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

TY-----GSIQVSVQALQQYD-----HWVIREFSI---SQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAGA
         |.| ... ....     . ...|  .     | . || |.||.. ||| |||    ..|...   |      .|  ||| ||||| 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagi
0048179 (Phosphotyrosine protein) phosphatases II 742-866 4.7e-27 89.9 In-house 21-139 (144) alignment 
Range on Protein: 742-866
Range on HMM: 21-139/144.0
SVQALQQYDHWVIREFSISQGDEIRKLT--QYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktaSDRPIVAHCSAGVGRTGTYIALDRLMqamqENDyID
... |...... .  .. .   |  . .  ||....|||||||| .  .|.|.. ..||..   ...|.. |||||||||||..|.....    ... ..
dlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.ls

IFGIICEMRMQRNHMVQTEKQYIFIHE
.. .. ..|..| ..|... |..|..|
leealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 540-720 6.2e-27 89.0 In-house 53-232 (305) alignment 
Range on Protein: 540-720
Range on HMM: 53-232/305.0
MVNRAKNRFTNILPYEHSRVKLAalaDDSDTDYINANYIPGYNSP-REFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY---
 .. .|||....   ..| |||.   . | .||| |||.     | . |...||||  |.|..| |. ..|   |||| . || ||.|| .||||     
diaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

NPVTYGSIQVSVQ---ALQQYDHWVIREFSISQ-GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAGA
  .  | .   |     ...     |  . ..  ||.   . . ..  ||| |||    | |... ..|       |  ||| ||||| 
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagi
subfamily_CG7180_pd Subfamily CG7180 722-870 1e-26 88.2 In-house 125-288 (296) alignment 
Range on Protein: 722-870
Range on HMM: 125-288/296.0
KCHEYWPADYnPVTYGSIQVSVQALQQYDHWVIREFSISQG------------DEIRKLTQYHFMSWPD-HGVPDKTWTMLDFVRTVREAIQKT---ASD
....||| .     || | | .   .|| . .||.| . .              | | ......  |.  . ||  | ......| ||  ..|.      
mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

RPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
 |.| ..| |..|.| |.|.|  .. ..... .|.|. .  .| .|...|.. ..| .| . . .
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 541-720 1.4e-26 88.2 In-house 42-215 (288) alignment 
Range on Protein: 541-720
Range on HMM: 42-215/288.0
VNRAKNRFTNILPYEHSRVKLAalaDDSDTdYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVT-
 | ...|..|.   . .||||    ||.|  ||.|| ..  . .| .. .| || ||.. .|.|. |.    ||||..|.|||| |  ||.|      . 
anptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGSIQVSVQ-ALQQYDHW-VIREFSISQGDEIRK-LTQYHFMSWPDHGVPEKTWTMLDFVRTVreaiqkTASDRPIVAHCSAGA
.| .   |.   .. |.  ..  . ||.  | .. . . |.  |.|.||||.  . | ..  .       . ..||| |.|||.
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGv
0049260 (Phosphotyrosine protein) phosphatases II 577-719 1.7e-26 88.2 In-house 1-99 (152) alignment 
Range on Protein: 577-719
Range on HMM: 1-99/152.0
YIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWpadynpvtygsiqvsvqalqqydhwvirefsisqgdeirkltQYH
.|.||. |.||.|.|||.| |..| |||..| . ..|||||.|.|.||.||..|.                                          ||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHCSAG
.. |||||||. .  .|.... ....  .  .. |.. |||||
hlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaG
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 721-874 3.8e-26 86.6 In-house 115-268 (283) alignment 
Range on Protein: 721-874
Range on HMM: 115-268/283.0
IKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVreAIQKTASDRPIVAHCSAGVG
|||  ||| .   . ||   |...     . ..|.|. . .     .   |. | .  | . |      ... | . .  . |.   . ||| |||.|.|
ikCsqyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvi..slqteskkgPivvhCstgiG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||...||.   .. .. .  .|.| ..  || ||  .|||  || ..|| |..    
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 530-633 4.6e-26 86.4 In-house 37-152 (350) alignment 
Range on Protein: 530-633
Range on HMM: 37-152/350.0
KDQAIVSALEMvnRAKNRFTNILPYEHSRVKLAA--------LADDSDTDYINANYIPGY------NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVM
 |  . . .|.   ||||..||||||||||||              |  |||||||.         |.   ..| |.||| ||||....| . |  .|..
nDvilseGvel..faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvils

LTQLVEKGKIKCHEYWPA
||..|| .  ||..||. 
ltsdvelnlekcyrYWqe
0049260 (Phosphotyrosine protein) phosphatases II 721-866 5.2e-26 86.6 In-house 49-144 (152) alignment 
Range on Protein: 721-866
Range on HMM: 49-144/152.0
IKCHEYWpadynpvtygsiqvsvqalqqydhwvirefsisqgdeirkltQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRTG
.||..|.                                          ||... |||||||| .  .|.... ....  .  .. |.. ||||||||||
lkceqyi..........................................qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtg

TYIALDRLMqamqenDYIDIFGIICEMRMQRNHMVQTEKQYIFIHE
|..|.. ..        .... ..  .|..|...|... |..|..|
tlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 528-723 2e-25 84.2 In-house 37-228 (301) alignment 
Range on Protein: 528-723
Range on HMM: 37-228/301.0
VGKDQaIVSALEMVNRAKNRFTNIlPYEHSRVkLaALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKC
. ||. |  ..  ... |.|. .. | . |   .  . .|     | ||.||    |. |.| ||||. | .|.| |.   .   ||||.| ||| . ||
idkdh.itesyaylpkdkhryptv.PckPsta.v.evivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

HEYWPADY-NPVTYGSIQVSVQALQQY--DHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaiqktaSDRPIVAHCSAGAI
.|| | .  . .  |  .. ..  ..   .. . |.. .       . | .| | ...|.|.|||.    . |..  |..      |..||| |||||  
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiG

KC
. 
rs
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 719-871 7.5e-25 82.6 In-house 120-276 (307) alignment 
Range on Protein: 719-871
Range on HMM: 120-276/307.0
GAIKCHEYWPADY-NPVTYGSIQ--VSVQ-----ALQQYDHW-VIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSDRPIV
. |||..|||..  .  ..|.    .||.      |   ..   . .. .  ... | .... .  |||.|||.   | .... .||          |.|
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvv

AHCSAGVGRTGTYIALDRLMQAM-QENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 ||||||||.|| .|.  ... | .  .  |.  .. |.| ||.. .||| ||...|  ... 
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 761-874 2.2e-24 80.7 In-house 181-289 (305) alignment 
Range on Protein: 761-874
Range on HMM: 181-289/305.0
QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDI-FGIICEMRMQRNHMVQTEK
 | . || |.||.. ||| |||    ..|...   |      .|  ||| |||||.||||. . |. ... . . . |.    |.  .| |||  .||..
pgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtda

QYIFIHECVMDLLRR
||.|.|. ... .|.
qylfvhqvilnyfrk
0044763 (Phosphotyrosine protein) phosphatases II 553-719 9.6e-24 79.4 In-house 1-120 (178) alignment 
Range on Protein: 553-719
Range on HMM: 1-120/178.0
PYEHSRVKLAALADDSDTDYINANYIPGYnsprEFMACQGPlpgtvDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNpvtygsiqvsvqalqq
|....||.|  | .   .|||||..| ..     ......|      | .....| . . ||.||. .| |..||..||| ...                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

ydhwvirefsisqgdeirklTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQktASDRPIVAHCSAG
                     ||... .||||||. .. .|.||. ..||..   ...|.. |||||
....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaG
0044763 (Phosphotyrosine protein) phosphatases II 721-872 1.3e-23 78.9 In-house 64-171 (178) alignment 
Range on Protein: 721-872
Range on HMM: 64-171/178.0
IKCHEYWPADYNpvtygsiqvsvqalqqydhwvirefsisqgdeirklTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVGRTG
.||..||| ...                                     ||... .||||||| .. .|.||. ..||..   ...|.. ||||||||.|
lkcdpywpeeag....................................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsg

TYIALDRLMQAmqendYIDIFGIICEMRMQRNhMVQTEKQYIFIHECVMDLL
| .|.. ...       .... .| ..|..|. .|... |. ...|. . ||
tlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 513-720 2.3e-23 77.5 In-house 3-203 (267) alignment 
Range on Protein: 513-720
Range on HMM: 3-203/267.0
DSDFRFTEEYDEIRLVGKDQAI-VSALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTS
|..  . .|...|. . ....     . . |...||. . |||...|| |     ... .|||| |. ||.  . |.. |.||  |. | . .| ..| .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

IIVMLTQlVEKGKIKchEYWPAD-YNPVTYGSIQVSVQALQQYDHWVIREFSI-SQGDEIRKLTQYHFMSWPDHgVPEKTWtmLDFVRTVREAIQKTASD
.||.||. | ...|.   .||    .   |  . |     .. . . |  . .  . .  ...| |..  |    . .| .  |  .  .    |    .
vivlltk.vftdnir..lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnin.tnnkpy..lkplfgilaknqlengn

RPIVAHCSAGA
||.| .||.| 
rPlvvacsdGv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 721-869 2.5e-23 77.3 In-house 120-274 (287) alignment 
Range on Protein: 721-869
Range on HMM: 120-274/287.0
IKCHEYWPADYNPVTYGSIQVSV--QALQQYDhWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVR---EAIQKTASDRPIVAHCS
 ||..|||    |.  |   | .  .  .. . . .| . . .  . | | . |....||||....  .  .. ||  |.   |. ....   |.| |..
lkcykywPerevPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhdd

AGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
.|.||.|...|.  |.. ...   .|.  ..  .|..|. .||.  |. .. | ..
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0051082 (Phosphotyrosine protein) phosphatases II 723-868 2.6e-23 77.7 In-house 49-149 (151) alignment 
Range on Protein: 723-868
Range on HMM: 49-149/151.0
CHEYWPADYnpvtygsiqvsvqalqqydhwvirefsisqgdeiRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktASDRPIVAHCSAGVGRTGTY
|.||.|.                                    ..........|||.|.|. . ..|.|.. ...      .. |.. |||||.||||| 
cpeylpelg..................................ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtl

IALDRLMQAmqendyIDIFGIICEMRMQRNHMVQTEKQYIFIHECV
.||.....       .... .. |.|..| ..||.. |..|.. ..
valylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 719-871 3.1e-23 76.9 In-house 132-282 (290) alignment 
Range on Protein: 719-871
Range on HMM: 132-282/290.0
GAIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWV-IREFSISQGDE--IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqktasDRPIVAHCSA
|  ||..|.|    . .|.|.| |     .. |  .  . .|. . |.    ||  .. .||||. |.  | ..|  .|..|.|        |.| ||||
GkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|.|||||..|..  .| . .   .|. ...  .|  |   || . ||. . | ..||
GiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 542-720 3.2e-22 73.5 In-house 52-234 (310) alignment 
Range on Protein: 542-720
Range on HMM: 52-234/310.0
NRAKNRFTNILPYEHSRVKLAaLADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYG
.  |||.....  . |||||  .      ||| |||.        |. .||||  |. |.||||.....  |..| . .|.|. ||  |||.     |||
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

SIQVSVQAlQQYDHWVIREFSIS----------QGDEIRKL--TQYHFMSWPDHGVPEKTwtmldfVRTVREAIQKTASDRPIVAHCSAGA
 |.|.  . .  . . | .....          |  ....|  .  ..  ||| |||..       . || . .       | | ||||| 
cirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvrhgpcvvhcsagk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 722-872 4.1e-22 73.2 In-house 126-293 (301) alignment 
Range on Protein: 722-872
Range on HMM: 126-293/301.0
KCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFS-----------------ISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTa
||..|||  . .  ..| ..| ..  | |  .|||...                 ...  . ....|..  .||..||     |.|  .  |  . ||  
kceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki.

SDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
.  |.| |||..|.|.|.|....  .   . .  .|.|...  .| ..  .|.| .||..|.. .   |
gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
0051082 (Phosphotyrosine protein) phosphatases II 570-720 3.7e-21 70.7 In-house 3-103 (151) alignment 
Range on Protein: 570-720
Range on HMM: 3-103/151.0
TDYINANYIPGYnspreFMACQGPLPgtvdDMWRMIWEKKTSIIVMLTQLVEKGkiKCHEYWPADYnpvtygsiqvsvqalqqydhwvirefsisqgdei
.||||..|. |.     . ...|||.    | .....| . . ||.|....| |  .|.||.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

RKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaiqktASDRPIVAHCSAGA
..........|||.|.|. . ..|.|.. ...      .. |.. ||||| 
ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGk
0049772 (Phosphotyrosine protein) phosphatases II 766-874 7.4e-21 70.6 In-house 178-282 (314) alignment 
Range on Protein: 766-874
Range on HMM: 178-282/314.0
RKLTQYHFMSWPDHGVPdKTWTMLDFVRTVREAiqktASDRPIVAHCSAGVGRTGTYIALDRLMQAMQendyIDIFGIICEMRMQRN-----HMVQTEKQ
|   .|. . .||...|  .  ...|.. ..||      ..|.. ||.||.|||||..... || ...    ...  .. ..|..|      ..... .|
rlgikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleq

YIFIHECVMDLLRR
|.||.|.....|..
yefilealleylkf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 744-873 2.1e-20 67.7 In-house 155-277 (312) alignment 
Range on Protein: 744-873
Range on HMM: 155-277/312.0
QALQQYDHWVIREFSISQGDEiRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqKtaSDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGI
.. ..  | |..    . |.|  || .| . ||||||.||   | | .. .|.    |    .|..|||||||||||| . .. .. |..     ..  .
kskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavk....k..dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkds

ICEMRMQRNHMVQTEKQYIFIHECVMDLLR
   .| .|   |..  ||..   ||...| 
fvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 518-720 3.9e-20 66.8 In-house 21-220 (312) alignment 
Range on Protein: 518-720
Range on HMM: 21-220/312.0
FTEEYDEIRLVGKDQAIVSALEMvnRAKNRFTNILPYEHSRVKLAAladDsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
.| ||  .  .  |    . | .  .  ||. ||  ..  |  ||    | .  || ||..     |  |...||||  |.  .|..     .. |..|.
ltkeykavgnivsdsectaflkf..kdlnrypniqcwdrgrftlag...d.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

QLVEKGKIKCHEYWPADYNPVT----------YGSIQVSVQALQQYDHWVIREFSISQGDEiRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqKta
 .|| |  || .|       |              |..  .. ..  | |..    . |.|  || .| . ||||||.|.   | | .. .|.    |  
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavk....k..

SDRPIVAHCSAGA
  .|..|||||| 
dkkpviahcsagv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 794-870 6.6e-20 66.2 In-house 181-257 (267) alignment 
Range on Protein: 794-870
Range on HMM: 181-257/267.0
TVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
 .    |    .||.| .||.||||.||.. .|  .. .....  |||  . ..| ||  .|.|  .||.||| . .
gilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 719-870 7.6e-20 65.7 In-house 134-287 (305) alignment 
Range on Protein: 719-870
Range on HMM: 134-287/305.0
GAIKCHEYWPADY---NPVTYGSIQVSVQ---ALQQYDHWVIREFSISQ-GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAH
| .|| .||||       .  | .   |     ...     |  . ..  ||.   . . ..  ||| |||    | |... ..|       |  ||| |
gklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvh

CSAGVGRTGTYIALDRLMQAMQENDYID-IFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||||.||||| .|.. ... . ||     .  ..  .| || . .|.. ||.|||  ...
csagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 763-872 8.7e-20 65.9 In-house 168-271 (288) alignment 
Range on Protein: 763-872
Range on HMM: 168-271/288.0
DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVreaiqkTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYI
.|   . . |.  |.|.|||..  . | ..  .       . ..||| |.||||||||| |     ..... .|.. |  .. ..| .| . .|||.||.
eekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqyl

FIHECVMDLL
..| ||.. |
yvhrcvleel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 530-649 5e-19 62.8 In-house 38-167 (349) alignment 
Range on Protein: 530-649
Range on HMM: 38-167/349.0
KDQAIVSALEMVnrAKNRFTNILPYEHSRVKLAAL------ADDSD--------TDYINANYI--PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSII
.|  . . .|.   ||||. .|||||||||||         .. |          |||||||.  . ..  . ..| | ||| |||| ...|  ..  ..
ddvilseGvelf..aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLTQLVEKGKIKCHEYWpadyNPVTYGSIQVSVQA
. |..  |..  ||. ||    .  .| .|.| .| 
lsLnddkelslekcdiyw....qelsysnitvklqn
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 541-732 1.1e-18 62.2 In-house 34-226 (285) alignment 
Range on Protein: 541-732
Range on HMM: 34-226/285.0
VNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYI--PGYNSpREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-
 |   ||....   | .|| |     . | ||| |...  || .    ... ||||| |. |.|.||...| . ..||  |.| |  ||  |.|      
anpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

VTYGSIQVSVQALQQY--DHWVIREFSISQGDEIRK----LTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKtasDRPIVAHCSAGAIKCHEYWPADY
| .|  ....   ..      ..  ... . ..       . . .   |||.  || .  |... . |..   |   ..||. |||||  .   .   ||
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidy

N
 
a
subfamily_egg_pd Subfamily egg 533-653 1.2e-18 61.8 In-house 31-152 (307) alignment 
Range on Protein: 533-653
Range on HMM: 31-152/307.0
AIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKgkIKCHEYWP
..  |..  |. | |   .   . |||||         |.| ||.. |     ||. .| ||  ||||.|||.....   |||||  .|    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

A-DYNPVTY--GSIQVSVQALQQY
  . ... .  ||...    ... 
kaesdslvtvpGslrienlkvdsk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 541-717 1.4e-17 58.2 In-house 46-219 (303) alignment 
Range on Protein: 541-717
Range on HMM: 46-219/303.0
VNRAKNRFTNILPYEHSRVKLaaladdSDTDYINANYIPgYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTY
 |  ||||....  .||.|||      ||. || |.|.   .| .  .  | ||. |  |.|.|| |.|   ...|    |  |.  .  .| . . . .
knmdknrfvdvicldhskvkl......sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GSIQVSVQALQQ---YDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEK-TWTMLDFVRTVREAIQKTASDRPIVAHCS
    . |  ...    | ||..  |.|.||    |  .|. .||   .| . .  ..  .  ..  ..| .  .| |    
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 722-871 2e-17 57.8 In-house 122-268 (281) alignment 
Range on Protein: 722-871
Range on HMM: 122-268/281.0
KCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAHCSAGVGRTG
|| ||.| .    . .  . || .        |   . .|   | | .|.. .  |||  ||. .  ||  .| .|      |   | | ||||||||.|
kcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir......arstppvihcsagvgrsg

TYIALDRLMQAMQEN-DYIDIFGIICEMRM-QRNHMVQTEKQYIFIHECVMDL
| .|..  .|...      ||  |.  .|.  |   ||| .||..| . ..|.
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 771-869 6.6e-17 55.9 In-house 193-285 (302) alignment 
Range on Protein: 771-869
Range on HMM: 193-285/302.0
YHFMSWPDHGVPDKTWTMLDFVRTVrEAIQKTasdrpIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
 .| .||||| |... | || ..   |. .|.     .. ||||||||||| .|.   .|  ....  |.  |.. .|  |   ||.|.| |..  || 
lafsawpdhGapkeaytaldilkfc.esykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 774-872 1.6e-16 55.1 In-house 175-270 (285) alignment 
Range on Protein: 774-872
Range on HMM: 175-270/285.0
MSWPDHGVPDKTWTMLDFVRTVREAIQKtasDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
  |||.  |. .  |... . |..   |   ..||. ||||||||| |.. .|     . ||  |... |. |||  | . ||.  |..|..  .|. .
pwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 723-865 1.9e-16 54.7 In-house 132-274 (301) alignment 
Range on Protein: 723-865
Range on HMM: 132-274/301.0
CHEYWPADY-NPVTYGSIQVSVQALQQY--DHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSDRPIVAHCSAGV
|.|| | .  . .  |  .. ..  ..   .. . |.. .       . | .| | ...|.|.|||     . |..  |..      |..||| |||||.
ceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGi

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIH
||. ..|. . | .... .  |..   . ..| .| . |||..|  .. 
Grsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 770-870 2.2e-16 54.6 In-house 219-342 (350) alignment 
Range on Protein: 770-870
Range on HMM: 219-342/350.0
QYHFMSWPDHGV---PDKTWTMLD----FV-RTVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQ------AMQE----NDYI----D-IFGIICE
| ..  |.| ..   | .  ..|.    ..   . |   ..|   ||. |||||||||||...|| |..       ...     |.     | |. |. |
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

MRMQRNHMVQTEKQYIFIHECVMD
.| ||  |||. .|.|||.|... 
lrkqrismvqnldqfifiYeallf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 717-884 9.2e-16 52.3 In-house 130-300 (310) alignment 
Range on Protein: 717-884
Range on HMM: 130-300/310.0
SAGAIKCHEYWPADYNPVTYGSIQVSVQAlQQYDHWVIREFSIS----------QGDEIRKL--TQYHFMSWPDHGVPDKTwtmldfVRTVREAIQKTAS
  |  ||  |||.     ||| |.|.  . .  . . | .....          |  ....|  .  ..  ||| ||||.       . || . .     
eegrpkcvgywpslgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvr

DRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMdLLRRGEEeDTGESI
  | | |||||..|... .||.  .. ... ...|.  .. |.. .|   .||| ||..|.   . .. |||. .. |.|
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifarget.evaeki
subfamily_eak_pd Subfamily eak 535-700 9.4e-16 52.1 In-house 47-208 (332) alignment 
Range on Protein: 535-700
Range on HMM: 47-208/332.0
VSALEMVNRakNrFTNILPYEHSRVKLAALADDSDtDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAD
 . || |||  |   .|.||..  |.|..   . .  ||||  .   .  |...    .    |  .|.|. |.|.  ||.| . ||..  |   |.| .
tarleavnr..n.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

Y-NPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTwTMLDFVRTVR
  . . .| ..|  .   . .    | . .|.|.|  ..  |..  | .  .|     .| . ....
treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye.dflalrkvmk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 809-875 3.3e-15 50.2 In-house 2-68 (69) alignment 
Range on Protein: 809-875
Range on HMM: 2-68/69.0
VAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
| |||.| |||||.||.   |  .. .  .|||  .  ||  |  ||  | .|||||. ... |. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 809-875 1.6e-14 48.0 In-house 1-67 (69) alignment 
Range on Protein: 809-875
Range on HMM: 1-67/69.0
VAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
| |||.| |||||.||.   |  .. .  .|||  .  ||  |  ||  | .|.|||. ... |. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 496-592 1.9e-14 47.6 In-house 3-95 (95) alignment 
Range on Protein: 496-592
Range on HMM: 3-95/95.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEmVNRAKNRFTNILPYEHSRVKLAAladDSDTDYINANYIPGYNSPREFMACQG
||| .  |  |   |...||  | .|.  | .       | . |  |  |||| ||.||. .|| |..     |.||||| .. ||     ..|.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsse.anipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_ptpA1_pd Subfamily ptpA1 743-831 3.4e-14 47.4 In-house 162-255 (418) alignment 
Range on Protein: 743-831
Range on HMM: 162-255/418.0
VQALQQYDHW-VIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTV--REAIQKTASDR--PIVAHCSAGVGRTGTYIALDRLMQA
|. .|. ..  . |.  ..   | | .|||..  |||| .||.|  . ......  |.     .|||  ||. |||||||||||. .   .|. 
veviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 584-719 1.2e-13 45.7 In-house 4-145 (199) alignment 
Range on Protein: 584-719
Range on HMM: 4-145/199.0
PREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFM
 | ..|.| ||  |. |.|.|.||  .  |||. .   . .     |||.       |||. |.....     ..|  . .    .     |....| | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPEKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAG
|| ..  |. .  .. || . ||  .|     | |.. ||| |
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 585-719 1.2e-13 45.7 In-house 4-144 (198) alignment 
Range on Protein: 585-719
Range on HMM: 4-144/198.0
REFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFMS
| ..|.| ||  |. |.|.|.||  .  |||. .   . .     |||.       |||. |.....     ..|  . .    .     |....| | |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAG
| ..  |. .  .. || . ||  .|     | |.. ||| |
wkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdg
subfamily_CG42327_pd Subfamily CG42327 803-868 1.9e-13 44.8 In-house 245-311 (319) alignment 
Range on Protein: 803-868
Range on HMM: 245-311/319.0
ASDRPIVAHCSAGVGRTGTYIALDRLMQAMQEN-DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECV
 |  |.| ||| ||||||. || |  .. ..|.   .||  ..  .| .| . |.| .|| ||.  .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 597-720 1.1e-12 42.6 In-house 40-159 (255) alignment 
Range on Protein: 597-720
Range on HMM: 40-159/255.0
TVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTyGSIQVSVQALQQYDHWVIREFSISQ----GDEIRKLTQYHFMSWPDHGVPEKTWTM
||| ....|  .||. .|||. . |.|. ||..|.| . .       .|.| . .   . |.|   |        . .... |..  |...  || .  .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl.kladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LDFVRTVREaiqktaSdRPIVAHCSAGA
|  .. ||.      | ...| |||.| 
lnilkvvrd......s.ksvvvhCstGi
0048076 (Phosphotyrosine protein) phosphatases II 645-719 1.1e-12 43.4 In-house 20-91 (145) alignment 
Range on Protein: 645-719
Range on HMM: 20-91/145.0
VSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKtasDRPIVAHCSAG
.... |...... .  ..  . .. |. .||....|||||||. . ..|.|.. ..||...   ..|.. |||||
ldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaG
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 726-865 2.3e-12 41.5 In-house 50-197 (199) alignment 
Range on Protein: 726-865
Range on HMM: 50-197/199.0
YWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAGVGR
|||.       |||. |.....     ..|  . .    .     |....| | || ..  |. .  .. || . ||  .|     | |.. ||| | | 
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgf

TGTYIALDRLMQAMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIH
|| ..|||  ... .|     .|.| .   .|  |  .. . ..| ||.
tgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 726-865 2.3e-12 41.5 In-house 49-196 (198) alignment 
Range on Protein: 726-865
Range on HMM: 49-196/198.0
YWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAGVGR
|||.       |||. |.....     ..|  . .    .     |....| | || ..  |. .  .. || . ||  .|     | |.. ||| | | 
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgf

TGTYIALDRLMQAMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIH
|| ..|||  ... .|     .|.| .   .|  |  .. . ..| ||.
tgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
PTPc_DSPc_SM00012 672-720 2.6e-12 42.2 In-house 2-50 (105) alignment 
Range on Protein: 672-720
Range on HMM: 2-50/105.0
LTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGA
...||...||||||||..  .|...| |..  .| .|  |.| |||||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 771-871 3.6e-12 40.3 In-house 186-284 (302) alignment 
Range on Protein: 771-871
Range on HMM: 186-284/302.0
YHFMSWPDHGVPDKTWTMLDFVRTVreAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
|..  |... ||.|  ..   .  |    .|. .| ..|     |.|| |. ..|   .. .|...   |  |.  .| || ..|.. |||.... ... 
yvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll

L
.
y
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 545-719 7.1e-12 40.1 In-house 22-201 (290) alignment 
Range on Protein: 545-719
Range on HMM: 22-201/290.0
KNRFTNILpYEHSRVKLAALADDSDTDYINANYIPgYNSPREFMACQGPLPG-------TVDDMWRMIWEKKTSIIVMLTQLVEKGKI----KCHEYWPA
..| .. |  |..|| |         ||| ||..  . .  .... | |.         |. . | |. . |   .||| .  || .      | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

DYN-PVTYGSIQVSVQALQQYDHWVIREFSISQGDEIR-KLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAG
  .  .... ..|. .   . |   .||  .  .||   ..| . . .| .  |.|.| |.|. ...|.      ||. |.. ||  |
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk......asktpvivHcvdG
subfamily_hpo-7_pd Subfamily hpo-7 596-720 8.1e-12 39.6 In-house 45-165 (263) alignment 
Range on Protein: 596-720
Range on HMM: 45-165/263.0
GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-VTYGSIQVSVQALQQydHWVIREFSISQ--G--DEIRKLTQYHFMSWPDHGVPEKTW
 |.| ....|  .||. .|||.   |.|. || .|.| . .    .  ..|..   |.    ...   . .  |   .......| .  |...  ||.. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

TMLDFVRTVREaiqktaSdRPIVAHCSAGA
 .|  .. .|.      | ...|.|||.| 
eilnilkvarn......s.kslvvhcstGi
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 722-871 1.6e-11 38.9 In-house 112-258 (290) alignment 
Range on Protein: 722-871
Range on HMM: 112-258/290.0
KCHEYWPADYN-PVTYGSIQVSVQALQQYDHWVIREFSISQGDEIR-KLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAHCSAGVGRT
 | .| |   .  .... ..|. .   . |   .||  .  .||   ..| . . .| .  |...| |.|. ...|.      ||. |.. ||  |. | 
aCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk......asktpvivHcvdGiSrs

GTYIALDRLMQAMQ-ENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 .  |..  .| .   .. . .  .. ..| ||.......... |.   .. |
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivll
0048179 (Phosphotyrosine protein) phosphatases II 646-719 4e-11 38.3 In-house 21-93 (144) alignment 
Range on Protein: 646-719
Range on HMM: 21-93/144.0
SVQALQQYDHWVIREFSISQGDEIRKLT--QYHFMSWPDHGVPEKTWTMLDFVRTVREAIQktaSDRPIVAHCSAG
... |...... .  .. .   |  . .  ||....|||||||. .  .|.|.. ..||..   ...|.. |||||
dlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaG
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 580-648 4.3e-11 36.8 In-house 231-296 (440) alignment 
Range on Protein: 580-648
Range on HMM: 231-296/440.0
GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKgkiKCHEYWPADYNPVTYGSIQVSVQ
||     |.| | ||  || |.||.. . . | |.|| || .|    |  ||| .   ||.| . |  .
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 552-685 5.3e-11 36.9 In-house 3-126 (130) alignment 
Range on Protein: 552-685
Range on HMM: 3-126/130.0
LPYEHSRVKlaaladdsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKgkikcHEYWPaDYNPVTYGSIQVSVQALQ
|..| ||..        . .||||...   .  .|..  | ||  |  |.|.|. |.   ..|.|  . |.      |||| | .|. .   .. |   .
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp.dsePlewyeediivtltd

QYDHWVIREFSISQGDEIRK----LTQYHFMSWPDHGV
. .   |.   .   ... .    || ..   ||  | 
rdefknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 804-870 5.9e-11 36.8 In-house 227-293 (297) alignment 
Range on Protein: 804-870
Range on HMM: 227-293/297.0
SDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
 . ... ||||||||.|  .  | ... .. .   |.  |.  .| ||  .||| .|. .... |. 
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
fn3 Fibronectin type III domain 18-97 1.2e-10 34.5 Pfam-A 2-81 (85) alignment 
Range on Protein: 18-97
Range on HMM: 2-81/85.0
AVGNISVTQYATTTADVQWNLMQ-CSDCIYNYFLLTFEPDSQEpIRVDYTTGVNEYSYQVSGLTEGRNYNFTVVSVSGVGV
|..|.||..  .|.. ..|.  .  .. | .| .   | ...|   . .|.  ...|....||..|..|.|.| .|.|.| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngage
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 800-871 1.6e-10 34.8 In-house 260-343 (349) alignment 
Range on Protein: 800-871
Range on HMM: 260-343/349.0
QKTASDRPIVAHCSAGVGRTGTYIALDRLMQ--AMQENDYID----------IFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 .|.   ... ||||| ||||... || |..   . .|..            |. |. |.| ||  |||  .|.|.|.|...  
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_PTPDC1_pd Subfamily PTPDC1 757-870 2.8e-10 34.9 In-house 71-174 (182) alignment 
Range on Protein: 757-870
Range on HMM: 71-174/182.0
FSISQGDEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKTasdrPIVAHCSAGVGRTGTYIALDrLMQAMQendyIDIFGIICEMRMQRNHMVQ
|| .. .  ..   .. ..|.|.||.  . ..|| |. |  |.|.      .  || || ||||  ||   |. | .    ..    |  .| .| . .|
fsYdlealmeqgiyvynfgwkDygvasle.riLdivkvvafalqeg....kvavhChaGlGrtGvliacy.lvyakr....ltaekaiklvrskrpksiq

TEKQYIFIHECVMD
| .|  ...|  . 
treqvelvkefalf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 719-880 3e-10 34.6 In-house 66-230 (255) alignment 
Range on Protein: 719-880
Range on HMM: 66-230/255.0
GAIKCHEYWPADYNPVTyGSIQVSVQALQQYDHWVIREFSIS----QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSdRPIVAHCSA
|  ||..|.| . .       .|.| . .   . |.|   |     .  . .... |..  |...  |. .  .|  .. ||.      | ...| |||.
gvekcssyfplekdekl.kladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrd......s.ksvvvhCst

GVGRTGTYIALDRLMQ----AMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL-RRGEEEDT
|.||. ...  . . |    ....     .|   .. |.| .|.  ..|  |  |    |.||.  .|| |. 
GiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleak
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 540-687 3.3e-10 33.1 In-house 25-156 (169) alignment 
Range on Protein: 540-687
Range on HMM: 25-156/169.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINAnyipgynsprefmacqgplpgtvddmwRMIWEKKTSIIVMLTQLVEKGKIKCH----EYWPADY
 .| .||| .  |   | ||||  . .|  .|||||                           |||||  .|.||.| .  .|  .       .  ||  
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavi

NPVTY-GSIQVSVQALQQYDHWVIREFSI-----SQGDEIR-KLTQYHFMSWPDHGVPE
    |  |. |  . ...  . |   | .     |  |..  ||. .|. .||. |||.
lgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpq
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 542-627 4.3e-10 33.6 In-house 34-118 (332) alignment 
Range on Protein: 542-627
Range on HMM: 34-118/332.0
NRAKNRFTNILPYEHSRVKLAAlaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDD-MWRMIWEKKTSIIVMLTQLVEKGKIKC
|   ||   .  ..||||.||   .|   |. ||... ||.    .. .| |.    .  .|||. |.| |.|... .. || | |.
nmdmnriphlycfdhsrvelap..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
PTEN_1 763-852 5.4e-10 34.4 In-house 89-175 (196) alignment 
Range on Protein: 763-852
Range on HMM: 89-175/196.0
DEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRTGTyIALDRLMQAMQeNDYIDIFGIICEMRMQRN
.....  .|. ....|||.|.    ..|... . |....  . . .. || ||.||.|| ..   ||....  .. . . ...|.|....
effksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGt.vvaayLmykgk.ltadeAlelvrekRppga
0038934 (Phosphotyrosine protein) phosphatases II 769-865 8.9e-10 34.0 In-house 80-170 (194) alignment 
Range on Protein: 769-865
Range on HMM: 80-170/194.0
TQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtASDRPIVAHCSAGVGRTGTYIALdrlmqAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIH
 .|. . .||.|..  . ..|.|.. | | ...  ..  .. || ||.||||| .|      .. .   ..    |  .|. |...... ...  ..
ieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaa.....YLiyrlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 747-868 1.2e-09 32.3 In-house 152-275 (303) alignment 
Range on Protein: 747-868
Range on HMM: 152-275/303.0
QQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDK-TWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRL-MQAMQENDYIDIFGII
.  | ||..  |.|.||    |  .|. .||   .| . .  ..  .  ..  ..| .  .| |    .|.||.||.  ..   .   .|.  .|.   .
elgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkcl

CEMRMQRNHMVQTEKQYIFIHECV
  .|  | | ||   |. ...  .
envrngrlhavqnlsqfsvvytll
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 540-623 1.6e-09 30.8 In-house 24-80 (169) alignment 
Range on Protein: 540-623
Range on HMM: 24-80/169.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINAnyipgynsprefmacqgplpgtvddmwRMIWEKKTSIIVMLTQLVEKG
 .| .||| .  |   | ||||  . .|  .|||||                           |||||  .|.||.| .  .| 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn
subfamily_hpo-7_pd Subfamily hpo-7 719-879 1.7e-09 32.0 In-house 72-234 (263) alignment 
Range on Protein: 719-879
Range on HMM: 72-234/263.0
GAIKCHEYWPADYNP-VTYGSIQVSVQALQQydHWVIREFSISQ--G--DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSdRPIVAHCS
|  || .|.| . .    .  ..|..   |.    ...   . .  |   .......| .  |...  | ..  .|  .. .|.      | ...|.|||
gvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarn......s.kslvvhcs

AGVGRTGTYIALDRLMQ----AMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
.|.||.  .   . . |    ....     .|   .. |.| .|.  ..|  |  |    |.|..     ..
tGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 663-722 2.1e-09 31.2 In-house 82-140 (440) alignment 
Range on Protein: 663-722
Range on HMM: 82-140/440.0
ISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGAIK
  .| | | | |||. .|||.|||. .  .| ... | |. |. |.. |.. |||||| .
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagr
subfamily_CG42327_pd Subfamily CG42327 694-799 4.7e-09 30.3 In-house 87-194 (319) alignment 
Range on Protein: 694-799
Range on HMM: 87-194/319.0
DFVRTVREaiQKtasDRPIVAHCS---AGAIKCHEYWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFmSWPDHGVPDKT
|| ||| |  |.    | ||  ..    |  .| ||.|.     |  .|| |.|...  .  |...|  . .   ...| |.|| | .  |.. .|| . 
dfwrtvwe..qq...srvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaee

WTMLDFVRTVREAI
 ...  .  ||...
aaliamllevrssl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 563-618 5.4e-09 30.0 In-house 64-118 (347) alignment 
Range on Protein: 563-618
Range on HMM: 64-118/347.0
ALADDSDTdYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQ
. |||..| |||| .|   |. .|..  | ||| || |.|.|.   | . .| . .
sraddvet.yinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 595-720 7.7e-09 29.4 In-house 101-232 (302) alignment 
Range on Protein: 595-720
Range on HMM: 101-232/302.0
PGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-VTYGSIQV---SVQ-ALQQY-DHW--VIR--EFSISQGDEIRK--LTQYHFMSWPD
  |..  | .| . ...|.| |...||... || ||.  . .  ...|   |   ||.  |... |    ..   |.  ..  .  |  .   .| .|||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpd

HGVPEKTWTMLDFVRTVrEAIQKTasdrpIVAHCSAGA
|| |... | || ..   |. .|.     .. ||||| 
hGapkeaytaldilkfc.esykkn.....vlvhcsaGv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 718-786 3.5e-08 27.6 In-house 113-184 (297) alignment 
Range on Protein: 718-786
Range on HMM: 113-184/297.0
AGAIKCHEYWPA-DYNPVTYGSIQVS--VQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTW
 |  ||  |||  . .  . |.. |    .  ...|. .. |. .   .| |...   |.||||||||    
dGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 536-583 4.2e-08 27.0 In-house 41-88 (440) alignment 
Range on Protein: 536-583
Range on HMM: 41-88/440.0
SALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNS
 |    |. |||. ||| |.|||| |  .    |.||||| || | .|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_eak_pd Subfamily eak 794-875 4.7e-08 26.8 In-house 226-308 (332) alignment 
Range on Protein: 794-875
Range on HMM: 226-308/332.0
TVREAIQKTASDRPIVaHCSAGVGRTGTYIALDRLMQAM---QENDYiDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
|..  |    |  ||.  .. |  |.|... .| |.. .   ..| |  .  .|  .. .|.| | ...|. ||.| |.| |.| 
tlkkyihtppsfapii.qsarGsaraGvfvvidllirlidnkkknly.svedlilkvkskrihsvlvalqhsfiyeivldyllrr
subfamily_PTEN_pd Subfamily PTEN 770-864 3.6e-07 25.3 In-house 81-172 (184) alignment 
Range on Protein: 770-864
Range on HMM: 81-172/184.0
QYHFMSWPDHGVPdKTWTMLDFVRTVREAIQKTAsDRPIVAHCSAGVGRTGTYIALdRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFI
. . .   ||  | .   . ..|..... ...   .. .| || || ||||. |.   |..... ..  ..  .  |.|.. .. |.   |  ..
rvavypfdDhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 535-581 4.5e-07 23.7 In-house 32-77 (244) alignment 
Range on Protein: 535-581
Range on HMM: 32-77/244.0
VSALEMVNRAKNRFTNILPYEHSRVKLAAlADDSDTDYINANYIPGY
..|.  .| .|||. ||||....|| |.. .    .|||||||| | 
tnavlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs
subfamily_egg_pd Subfamily egg 720-873 1.3e-06 22.3 In-house 120-271 (307) alignment 
Range on Protein: 720-873
Range on HMM: 120-271/307.0
AIKCHEYWP-ADYNPVTY--GSIQVSVQALQQYDH--WVIREFSISQGDEIRKLTQyHFmSWpDHGVPDKTWTMLDFVRTVREAiqktasDRPIVAHCSA
. .|. ||| |. ... .  ||...    ...     . . .. .  ||.  .  . |.  . |     . .. |  .| .|..       .|.| ..  
serceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerfle.hw.qg.dvnnssdvysplrvlrklrnl......skpvvvqdil

GVGRTGTYIALDR-LMQAMQENDYI-DIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|| ...| .|..  |.. ..   .   .   .  .|..|.  |..  .|.|..  |. ..|
GvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
fn3 Fibronectin type III domain 205-243 2.8e-06 20.6 Pfam-A 1-39 (85) alignment 
Range on Protein: 205-243
Range on HMM: 1-39/85.0
SPVGNPQAEAVDKNTITLTYESPLEPNGDITGYRISYIG
|...|.....|  ...||. . | ...|.||||.. |  
saPenlsvsevtstsltlsWsppkdgggpitgYeveyre