Gene PTPRB-6 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP072_AA protein Get Run
SpurP072_AA_770-992 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 793-994 1.8e-79 261.8 In-house 88-288 (293) alignment 
Range on Protein: 793-994
Range on HMM: 88-288/293.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHFI
.|.| |.|.||||||. .||..||||||||.. .|||| ...|.||.||..||| ...|...|.. || .||.. . |..|..... ..||| .|||||.
pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhft

SWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFLQ
||| |  |  ... |.||...||..|. . ..|.|||| ||.||||.||||| |||...  | .||.|..||..|.||..|||.  ||||.|... |.|.
sWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr

GQ
 .
kk
subfamily_PTPRD_pd Subfamily PTPRD 793-1003 3e-76 252.3 In-house 85-293 (564) alignment 
Range on Protein: 793-1003
Range on HMM: 85-293/564.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSdPTVFGKVIVTKLAEHTHDTWAVRDFRL--KVGSEERLIRQYH
||..|...|||||||...|...|||||||...  |||| .. | ||.||.|||| .. .. .|...||  .|..  .  .|.|.|  |  || | .||.|
dgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFh

FISWPTHSTPRVSRPTLNFVKNIREELesPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
|.||| |  |   .. |......|.    .. .||.|||| ||.||||.||..|..|. .|. |.|||.. .|...|..|  .||.  ||||.|.|....
FtsWPdhgvpesatslLdlirkvraln..epdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailea

LQGQGHGVEVSSI
|. .   ||....
lacgntevesenl
0051299 (Phosphotyrosine protein) phosphatases II 768-991 8.4e-70 230.8 In-house 5-286 (288) alignment 
Range on Protein: 768-991
Range on HMM: 5-286/288.0
ILSSQFPLHYNEMVADKQHKFTMEF--------------------------------------------------------DGFNKPQEYIATQGPMSNT
|  ...  ......|. .... .||                                                        ||.|.....||||||..||
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

VHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPInSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK------VGSEERLIRQYHFISWPTHSTPRVSRP
|..|||||||.... |||| ...| |.|||..|||  ......|.. || | |...|.. || ....       ..|.| ....|...|| |..|   ..
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

TLNFVKNIREELEspKLSGPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
 |.|.. .|. |.  . .|| |||| ||.||||.|||||.||. |..  ..|||. .|...|. |. .||.. ||.|...||...|
lldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 793-992 2.8e-69 229.1 In-house 100-300 (308) alignment 
Range on Protein: 793-992
Range on HMM: 100-300/308.0
DGF--NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPIN--SDPTVFGKVIVTKLAEHTHDTWAVRDFRLKV--GSEERLI
||.  ..|...||||||..|||. ||||||| ... |||| ...| |.|||..||| .  ......||. || | |...|.. || ..|.   ..|.| .
dgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtv

RQYHFISWPTHSTPRVSRPTLNFVKNIREELESpklsGPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
...|...|| |..|   .. |.|.. .|. |..    || |||| ||.||||.|||||.||. |... ..|||| .|.|.|. |.  ||.. ||.||.||
thfhytnWpdhgvPpspeilldflelvrkslpg....gpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyra

LADFLQ
|...|.
lleylk
0046845 (Phosphotyrosine protein) phosphatases II 793-992 5.7e-69 227.9 In-house 66-275 (284) alignment 
Range on Protein: 793-992
Range on HMM: 66-275/284.0
DGF-----NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKV---GSEER
||.     ......||||||..|||..|||||||.... |||| ...| |.|||..||| .... ..|...|| | |...|.. || ..|.    ..|.|
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

LIRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADER--TVDVFAVVAKMRRERCSLVQSLVQYIF
 ....|..||| |..|  ... |.|.. .|| ||. . .|| |||| ||.||||.|||||.||. |.....  .|||. .|...|. |.  ||.| ||.|
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf

LHRALADFLQ
...||...|.
vyealleylk
0036941 (Phosphotyrosine protein) phosphatases II 792-994 4.5e-67 221.8 In-house 71-280 (297) alignment 
Range on Protein: 792-994
Range on HMM: 71-280/297.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPIN-SDPTVFGKVIVTKLAEHT--HDTWAVRDFRLKV--GSEERLI
 ||.. ....||||||..|||..|||||||  .. ||||....| |.|||..||| .  .. ..|...|| | ...  .|.. .| ....   ..|.| .
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

RQYHFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKA--DERTVDVFAVVAKMRRERCSLVQSLVQYIFLH
...|...|| |..|   .. |.|.. .|. |.    .|| .||| ||.||.|.|||.|..|| |.    |..||.. .| |.|. |.  ||.| ||.||.
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

RALADFLQGQ
.||...|. .
eallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 792-991 5.9e-67 221.3 In-house 70-272 (273) alignment 
Range on Protein: 792-991
Range on HMM: 70-272/273.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSD--PTVFGKVIVTKLAEHTHDTWAVRDFRLKV--GSEERLIR
 ||.|.....||||||..|||..|||||||. .. ||||....| |.|||..||| . .  ....||..|| | |.|.|.. || ..|.    .|.| ..
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

QYHFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
..|. .|| |..|    . |.|.. .|. ||. . .|| |||| ||.||||.|||||.||. |..  ..|||. .|...|. |.  ||.. ||.||..||
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyeal

ADFL
...|
leyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 792-993 1.4e-65 216.2 In-house 83-281 (288) alignment 
Range on Protein: 792-993
Range on HMM: 83-281/288.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHF
.|| .| ..|||||||. .||..||..|.|..   ||||   .||||.||..||| . .|. .|.| || . ... . . .| . |.   .|. | ||..
idgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqy

ISWPTHSTPRVSRPTLNFVKNIREELESPklSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
 .|| |. |. ..| |......    ..   .||..||| ||.||||.||||| |...... | ..||...|||.|..| .||| | ||.|....|..  
laWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsli

QG
. 
ee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 792-1001 2e-65 215.9 In-house 82-290 (318) alignment 
Range on Protein: 792-1001
Range on HMM: 82-290/318.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPiNSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKV--GSEERLIRQY
 ||... ..|||.|.|...|...|||||||...  |||| .. | ||.|...||| ..... .||. |.   | . ... .| |...    .|.| .|||
idGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqy

HFISWPTHSTPRVSRPTLNFVKNIReELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
|. ||| ...|  .   |..|.... . . ..  ||.|||| ||.||||||||.||||. .|| | .|||| .| ..|..|  .||   ||.|.. .| .
hytsWpdegvpesgaslldlvrqvs.kaqqksgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvlle

FLQGQGHGVEVS
.|.     |. |
alasgdtevdas
DSPc_SM00195 793-991 4.1e-65 215.1 In-house 63-262 (263) alignment 
Range on Protein: 793-991
Range on HMM: 63-262/263.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS-DPTVFGKVIVTKLAEHTHD-TWAVRDFRLKVGS--EERLIRQ
.| ||...|||||||...||..|||||||.... ||||... | ||||||.||| .| ....|||. |.   .....  . .|...|.     |.| ..|
kgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtq

YHFISWPTHSTPRVSRPTLNFVKNIREELESPklSGPLVVHCGAGIGRTGVFIALDILLQELKADERtVDVFAVVAKMRRERCSLVQSLVQYIFLHRALA
|.. .|| |..|   ...|.... .... ..   |||.|||| ||.||||.|...||.|..|..... ||.|..| ..| .|...||.| ||.|...|..
yqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeail

DFL
...
eyi
PTPc_SM00194 793-991 4.1e-65 215.1 In-house 63-262 (263) alignment 
Range on Protein: 793-991
Range on HMM: 63-262/263.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS-DPTVFGKVIVTKLAEHTHD-TWAVRDFRLKVGS--EERLIRQ
.| ||...|||||||...||..|||||||.... ||||... | ||||||.||| .| ....|||. |.   .....  . .|...|.     |.| ..|
kgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtq

YHFISWPTHSTPRVSRPTLNFVKNIREELESPklSGPLVVHCGAGIGRTGVFIALDILLQELKADERtVDVFAVVAKMRRERCSLVQSLVQYIFLHRALA
|.. .|| |..|   ...|.... .... ..   |||.|||| ||.||||.|...||.|..|..... ||.|..| ..| .|...||.| ||.|...|..
yqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeail

DFL
...
eyi
0040438 (Phosphotyrosine protein) phosphatases II 792-993 7.6e-65 214.6 In-house 79-278 (317) alignment 
Range on Protein: 792-993
Range on HMM: 79-278/317.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPInSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK--VGSEERLIRQY
 ||.|.....||||||..|||. |||||||  .  ||||... | |.|||..|||   .....|...|| | |.... . .| ....   .||.| ....
vdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthf

HFISWPTHSTPRVSRPTLNFVKNIREELEspKLSGPLVVHCGAGIGRTGVFIALDILLQELKADErTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
|...|| |..|   .. |.|.. .|| ||  . .||..||| ||.||||.|||....|. |.  . .|||. .|...|. |.  ||.. ||.||..||..
hytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalle

FLQG
.|. 
ylkr
0045450 (Phosphotyrosine protein) phosphatases II 771-991 1.6e-64 213.9 In-house 12-304 (307) alignment 
Range on Protein: 771-991
Range on HMM: 12-304/307.0
SQFPLHYNEMVADKQHKFTMEF-------------------------------------------------------------------DGFNKPQEYIA
 .. |.......|  ...  ||                                                                   ||.......||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

TQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK---VGSEERLIRQYHFISWPTHSTP
||||...||..||||.||. . .|||| ...| |.|||..||| .... ..|.. || | |...| . || ....     .|.| ....|...|| |..|
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

RVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERT--VDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
    ..|.|.. .|. ||. . .|| .||| ||.||||.|||....|. |.... .  ||.. .|...|. |.  ||.. ||.||..||...|
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 775-992 3.3e-64 212.5 In-house 21-290 (297) alignment 
Range on Protein: 775-992
Range on HMM: 21-290/297.0
LHYNEMVADKQHKFTMEF-------------------------------------------------------DGFNK-PQEYIATQGPMSNTVHEFWRM
|..  . |.. ... .||                                                       ||... ....||||||...||. ||||
lllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VWEKECPAIVMLVRCIEGGKeKCDKYWPINSDptVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREELE
|||  ...|||| ...| |. ||..||| ...  ..|.. || | ....| . || .... ..|.| ........|| |..|  ..  |.|.. .|| |.
vweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

SPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFLQ
. . .|| .||| ||.||||.|||....|. |.   ..|||. .|...|. |.  ||.. ||.||..||...|.
elpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 773-990 7.6e-63 207.9 In-house 7-276 (278) alignment 
Range on Protein: 773-990
Range on HMM: 7-276/278.0
FPLHYNEMVADKQHKFTMEF-------------------------------------------------------DGFNKPQEYIATQGPMSNTVHEFWR
.. ...|.... ....  ||                                                       ||.|.|...||||||...||. |||
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

MVWEKECPAIVMLVRCIEGGKEKCDKYWPinSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK--VGSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIRE
||||  .. ||||... | |..||..|||  ......|.. || | |...|.. ||.....    .|.| ...||...|| |..|    . |.|.| .||
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

ELEspKLSGPLVVHCGAGIGRTGVFIALDILLQELKADErTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
 ||  . .||..||| ||.||||.||||..||. |.    .||.. .|...|. |.. ||.. ||.||..||...
ale..dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 793-992 1.4e-62 206.3 In-house 78-277 (281) alignment 
Range on Protein: 793-992
Range on HMM: 78-277/281.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRL-KVGSEERLIRQYHF
.|.....||||||||. .....||.||||..  ||||. | ||.|| || .||| ..  . .|.|.|...||... |.. | |.| . ..|.| ..| ..
pgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlay

ISWPTHSTPRVSRPTLNFVKNIREeLESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
..|| |  |  ..  |.| |.... |...|   |||.|| ||.||||..|||| |.....|.....|| ||||..|.||  .||..||| |...|. | |
taWPdhGvPattkellefrkevlk.ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

Q
.
d
Y_phosphatase Protein-tyrosine phosphatase 793-988 1.5e-62 206.5 Pfam-A 36-234 (235) alignment 
Range on Protein: 793-988
Range on HMM: 36-234/235.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWP-INSDPTVFGKVIVTKL-AEH-THDTWAVRDFRLK-VGSE--ERLI
.|.......||||||...|...||||||.... .||||... | |.|||..|||  ..... .|.. |.    |.  .. ...|...||  ..|  .| .
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

RQYHFISWPTHSTPRVSRPTLNFVKNIREELesPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
.|.|. .|| |..|. ... |.........    . |||.|||| ||.||||.|.||||||..|.| |..|||. .| ..|..|...|||| |||||..|
kqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivkelRkqRpgmvqsleqYiflyka

LA
..
il
Y_phosphatase Protein-tyrosine phosphatase 793-988 1.5e-62 206.5 In-house 36-234 (235) alignment 
Range on Protein: 793-988
Range on HMM: 36-234/235.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWP-INSDPTVFGKVIVTKL-AEH-THDTWAVRDFRLK-VGSE--ERLI
.|.......||||||...|...||||||.... .||||... | |.|||..|||  ..... .|.. |.    |.  .. ...|...||  ..|  .| .
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

RQYHFISWPTHSTPRVSRPTLNFVKNIREELesPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
.|.|. .|| |..|. ... |.........    . |||.|||| ||.||||.|.||||||..|.| |..|||. .| ..|..|...|||| |||||..|
kqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivkelRkqRpgmvqsleqYiflyka

LA
..
il
0040439 (Phosphotyrosine protein) phosphatases II 792-991 2.5e-60 199.5 In-house 47-246 (249) alignment 
Range on Protein: 792-991
Range on HMM: 47-246/249.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPInSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK--VGSEERLIRQY
.||.. ....||||||...||. ||||.||  . .|||| .. | |.|||..|||  ......|.. || | ....| . || ..|.    .|.| ....
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

HFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
....|| |..|    ..|.|.. .|. ||. . .||..||| ||.||||.|||....|. |.  |..||.. .|...|. |.  ||.. ||.||..||..
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqle.kelgvdleeavkllrsqRpgavqnpeqyrflyealle

FL
.|
ll
subfamily_PTPN12_pd Subfamily PTPN12 794-993 5.7e-60 197.6 In-house 78-279 (290) alignment 
Range on Protein: 794-993
Range on HMM: 78-279/290.0
GFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTV-FGKVIVTKLAEHTHD-TWAVRDFRLKVGSEERLIRQYHF
| ....||||.|||...|...||||.|||.   .||. | .| || ||..||| . . .. ||.. ||. .|.. |  . .| ..... .|.| ..|.|.
gvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhY

ISWPTHSTPRVSRPTLNFVKNIREELEspKLSGPLVVHCGAGIGRTGVFIALDILLQELKADER--TVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
 .|| | .|.   . |......||  |  . . |||||| ||.||||. ||.|.  . |||.    ..||| .|...|..| .|||.  || ....|.|.
taWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

FLQG
..| 
lvqk
subfamily_PTPRG_pd Subfamily PTPRG 793-1005 1.3e-59 196.9 In-house 85-301 (563) alignment 
Range on Protein: 793-1005
Range on HMM: 85-301/563.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPInSDPTVFGKVIVTKLAEHTHDTWAVR-----DFRLKVGSE---ER
||..| ...||||||. .|.. ||||.||..   |||.    | |..||| |||   ..  .|.. ||  .|... . .||     ...|| ...   |.
dGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdtek

LIRQYHFISWPTHSTPRVSRPTLNFVKniREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLH
|.||||. .|| |..|  | | |.|||  ...   ..  ||.|||| ||.||||..|.|| ||..... | .|.|| .. ..| .|  |||.  ||||||
lvrqyhytkWPdhgvPehslpvLifvk..kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflh

RALADFLQGQGHGVEVSSIER
 || . ....   .  . .|.
dalleaiasketellaeqvee
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 772-993 2.6e-59 195.9 In-house 62-285 (305) alignment 
Range on Protein: 772-993
Range on HMM: 62-285/305.0
QFPLHYNEMVADKQHKFTMEFDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDP-TVFGKVIVTKLAEHTHDTW
.. |  .| . |...      ||... ..||..|||. |||..|||...|     ||||.. .||||.|| .||| .    . ||...|.   |.|   .
riiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdy

AVRDFRLKV---GSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPKlSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMR
  |.... .    .|.| . ||.. .|| |  |. .   |...|..... .. |   ||.||| ||.||||||||.|| |. ||. | .|||| |. ..|
ieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk.gvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlR

RERCSLVQSLVQYIFLHRALADFLQG
..|  .||.| || ||| ||.. .. 
skrmkmvqtldqYvflhdaldelitc
subfamily_PTPN6_pd Subfamily PTPN6 797-993 5e-59 194.8 In-house 96-299 (306) alignment 
Range on Protein: 797-993
Range on HMM: 96-299/306.0
KPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRL---KVGSEERLIRQYHFIS
. ..|||||| ...|| .||||||....  |||. . .| ||||| .||| ... . .||. ||...|...... .|....   | ..||| ..|||| |
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks

WPTHSTPRVSRPTLNFVKNIREELESPK--LSGPLVVHCGAGIGRTGVFIALDILLQELKAD--ERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
|| |..|.     |.|....... |. .   .||.|||| ||||||| || .||||. ..    .  .|.  .| ..|. |  |||   || |...|.. 
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

FLQG
... 
yiet
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 792-1002 7.4e-59 194.4 In-house 84-294 (319) alignment 
Range on Protein: 792-1002
Range on HMM: 84-294/319.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPiNSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEE---RLIRQ
 ||... ...||||.|..||...|||||||.|.  .||| .  | .| |. |||| . .....|..||| . |.  . . .|.. |.  |.|   | . .
idgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp.eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkh

YHFISWPTHSTPRVSRPTLNFVKNIREELESPkLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALA
... .|| |  |. ..  |...|.||.  | .  |||.|||| ||.|||| ||.||. |. .|  | ..||| .| ..|  |  .||   ||.|.. || 
fqyteWpdhdvPekatslldllkrirksrekt.qsgPivvhCsaGvGRtGtfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyeall

DFLQGQGHGVEVSS
....     .||  
eaveagdteievqd
0042113 (Phosphotyrosine protein) phosphatases II 793-991 1.5e-58 193.4 In-house 46-243 (245) alignment 
Range on Protein: 793-991
Range on HMM: 46-243/245.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPInSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK--VGSEERLIRQYH
||.. .. .||||||...||. ||||.||  . .|||| .. | |..||..|||  ......|...|| | |...|.. || ....    .|.| ...||
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

FISWPTHSTPRVSRPTLNFVKNIREELESpKLSGPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
...|| |..|  ..  |.|.. .|. |.. . .||..||| ||.||||.|||....|. |..  ..|... .|...|. |.  ||.. ||.||..||...
ylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallel

L
|
l
0045098 (Phosphotyrosine protein) phosphatases II 793-992 2.2e-58 193.2 In-house 60-273 (278) alignment 
Range on Protein: 793-992
Range on HMM: 60-273/278.0
DGFnkPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPiNSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK------VGSEERLI
||.  |...||||||. .||. ||||.||  ...|||| ...|.|.|||..||| .... ..|.. || | |...|.. .|....        . |.| .
dgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgv

RQYHFISWPTHSTPRVS--RPTLNFVKNIREELE-----------SPKLSGPLVVHCGAGIGRTGVFIALDILLQELkadERTVDVFAVVAKMRRERCS-
...|...|| |..|  .  .. |.... ||| |.               .|| .||| ||.||||...|....|. |   |..||.. .|...|. |.  
thlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpgl

LVQSLVQYIFLHRALADFLQ
 ||.| ||.||...|...|.
avqnleqyrflyefllelll
subfamily_Ptp69D_pd Subfamily Ptp69D 793-993 2.7e-58 192.5 In-house 85-288 (307) alignment 
Range on Protein: 793-993
Range on HMM: 85-288/307.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINsDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGS-------EERL
 |... ...|| |.|. .|...||||..|.|   ||||    |  ..||.|||||. | . .|...|.   |..|. .. |.. .           ..| 
kgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrk

IRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPklSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHR
. |||. .|.    |.|.|  |......||  .     .|.|||| || ||.|.|.|||.|||.||| | .||.|..| ..|..|  ||||| ||.||.|
vvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyr

ALADFLQG
||.|. . 
alldyssy
subfamily_PTPRA_pd Subfamily PTPRA 792-1005 2.5e-57 189.2 In-house 94-309 (330) alignment 
Range on Protein: 792-1005
Range on HMM: 94-309/330.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDpTVFGKVIVTKLAEHTHDTWAVRDFRLK-VG-----SEERL
 ||... ...||.||| ..||..||||.||..  .||||    |  .||| .||| .     .|.. |.   |     ..||.| .. ..      ..||
idGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrl

IRQYHFISWPTHSTPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHR
.||.|| |||    |  ..  |...|....    .. .||.|||| ||.|||| ||.|| .|. .|| || |||| .| ..|  |. .||.. || |...
vrqfhftswPdvGvPfepiGmlkllkkvkkl..nqqsagpivvhcsaGvGrtGtfivldavlervka.erkvdvfefvkrlrlqrpqmvqtdeqyefiyk

ALADF-LQGQgHGVEVSSIER
.| .. | |.   ..|||.|.
vlleyylygd.teldvsslek
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 792-993 2.9e-57 189.0 In-house 85-282 (315) alignment 
Range on Protein: 792-993
Range on HMM: 85-282/315.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINsdPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHF
 ||.||.. |||.|||  ..|..|||.|.|...  ||||   .|| |.|..|||| .    ..||. ||.  |  .. ..|| .   .|.. | . |.|.
idGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhy

ISWPTHSTPRVSRPTLNFVKNIREELESPKlsGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL-ADF
 |||.   |. . | .|......   ..    |..|||| ||.|||| ||.|| .|....| |. .||. .. ..|. |  .||.. || |.. ||   |
tswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydalletf

LQG
. |
vcg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 797-992 8.3e-57 187.4 In-house 71-269 (274) alignment 
Range on Protein: 797-992
Range on HMM: 71-269/274.0
KPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDP---TVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHFIS
. . |.|||||..|||..||||....|.. |||| .  |  ..|| .|.| . |      .|.| ..     ... . || . ||  ..|| .  | . .
eskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytd

WPTHSTPRVSRPTLNFVKNIREELESPKLS-GPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFLQ
|| | .|.  .. |..|....|. |. .   .| |||| |||||||.||| .| ...|...  .|||. .|...| .|  .||.  || ..||||. .|.
WPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlree.ivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 793-993 6.1e-56 185.0 In-house 98-294 (319) alignment 
Range on Protein: 793-993
Range on HMM: 98-294/319.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVrcieggKEKCDKYWPINSDPTVF-GKVIVTKLAEhTHDtWAVRDFRLKV---GSEERLIRQ
.|. ... |||.|||. ||. .||||.|| .| .||.|       |.|| .||| . . .   .|| |. . | |.. ..|||..|       . | |.|
tGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee.tae.yvvrdielsedgkekdirkitq

YHFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALA
.||  || .  |  . . . .||..|   .  .   ..|||| ||.|||||.|.||.||. .| .|. |||. .|  .|..|  |||.|||| |.. || 
fhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmk.eekqvdvynfvrdlrqqrntlvqdlvqykfiysall

D-FLQG
. .| |
eehlfg
subfamily_PTPRK_pd Subfamily PTPRK 792-1003 8.7e-56 184.0 In-house 79-289 (314) alignment 
Range on Protein: 792-1003
Range on HMM: 79-289/314.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPtvFGKVIVTKLAEHTHDTWAVRDFRLKV----GSEERLIR
 |....|...|.||||. .||..|||.|....| .||||   .| |. || |||| ...   .|.. |. .  ...    || ||..      .| |..|
idsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevr

QYHFISWPTHSTPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
|..|..||.| .|   .  |..|... .   ...  |..|||| || ||||.|||.||.|. ..  |..|||| .| ..| ..  .|.   ||.|.. ..
qfqflgWpdhdvPvsatgllklvrrvkks..qeeeaGrivvhCsaGaGrtGtfiaidivldmie.regvvdvfnavktlrsrkvnmveteeqykfiydvi

AD-FLQGQgHGVEVSSI
 .  | |.   . || .
leaclcge.taipvsef
0037934 (Phosphotyrosine protein) phosphatases II 796-989 1.6e-55 183.6 In-house 44-240 (243) alignment 
Range on Protein: 796-989
Range on HMM: 44-240/243.0
NkpqEYIATQGPMSNTVHE----FWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPinsDPTVFGKVIVTKLAEHTHDTWAVRDFRLKV---GSEERLIRQ
.    .||||||...||..    ||||.||  . .|||| ...| |.|||..|||   .....|...|| | |...| . || ..|.    . ..||...
p...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvih

YHFISWPTHSTPRVSRPTLNFVKNIREELES------PKLSGPLVVHCGAGIGRTGVFIALDILLQELkaderTVDVFAVVAKMRRERCS-LVQSLVQYI
||...|| |..|    . |.|.. .|| .|.       . .||..||| ||.||||..||....|. |     .||.. .|...|. |.   ||.. ||.
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyr

FLHRALAD
||..||. 
flyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 793-993 3.1e-55 182.7 In-house 62-258 (284) alignment 
Range on Protein: 793-993
Range on HMM: 62-258/284.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVrcieggKEKCDKYWPINSDPTVF-GKVIVTKLAEhTHDtWAVRDFRLKV---GSEERLIRQ
 |. ... |||||||. ||. .||||.|| .| .||.|       |.|| .||| . . .   .|| |. . | ... ..|||..|       . | |||
tGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee.see.yvvrdielsedgkekdirkirq

YHFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALA
.||  || .  |  . . . .||..|   .  .   ..|||| ||.|||||.|.||.||. .| .|. |||. .| ..|..| .|||.|||| |.. || 
fhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk.eekqvdvynfvrdlrqqrntlvqdlvqykfiysall

D-FLQG
. .| |
eehlfg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 793-992 5.3e-54 178.5 In-house 93-291 (298) alignment 
Range on Protein: 793-992
Range on HMM: 93-291/298.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINsDPTVFGKVIVTKLAEHTHDTWAVRDFRL--KVGSEERLIRQYH
..... . .||||.|. .||..|||||.|..  .||||    | .| |. |||| .   . .|.. |. |.....   .|| . .  |  ..|| .|| |
haykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlh

FISWPTHSTPRVSRPTLNFVKNIREeleSPKLSG--PLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALA
|.||| ...|....  |......|    |.. .|  |..|.| ||.||.| |||.| .|. .|. |..|||| ||  .|..|. .||.  ||.|.. |  
ftsWpdkgvpenatsvldllrkvra...sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl

DFLQ
..|.
eald
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 792-992 1e-53 177.1 In-house 45-243 (250) alignment 
Range on Protein: 792-992
Range on HMM: 45-243/250.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEkCDKYWPINSdPTVFGKVIVTKLAEHTHDTWAVRDFRLKVG--SEERLIRQY
 .|... . .||||||...|. .|||||.|..  .||||    | .|. . .|||..  .. .|.| |. | ....  . .| . |     ..||..||.
lhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.aekyGdvtvsllskeefadytkrklklskakkaderivrql

HFISWPTHSTPRVSRPTLNFVKNIREELESPkLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
||..||  . |.| .  |...|... . .    ..|..|.| ||.||.| |||.| .|. ||  |..|||| |. ..|..|   |.|| ||.|.....  
hfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaidavlerlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilk

FLQ
.|.
ald
subfamily_PTPN3_pd Subfamily PTPN3 789-986 2.2e-53 176.0 In-house 74-270 (280) alignment 
Range on Protein: 789-986
Range on HMM: 74-270/280.0
TMEFDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGS--EERLI
 || .. .  . |||||||...|...||.||||...  ||||   .| |. || .||| ..| . .|.  |.   |... ....|.. ||  .  ||| |
nmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerki

RQYHFISWPTHSTPRVSRPTLNFVKNIREELESpkLSGPLVVHCGAGIGRTGVFIALDILLQeLKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
 |  ...|| |. |  |   |.||...|.  ..   . |.|||| ||||||||.|.|.. |. |   .. | . ..| .||  | .|||.  || |.  |
lqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_PTPN9_pd Subfamily PTPN9 792-991 4.7e-53 175.1 In-house 78-290 (297) alignment 
Range on Protein: 792-991
Range on HMM: 78-290/297.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPIN-SDPTVFGKVIVTKLAEHTHDTWAVRDFRLK--VGSEERLIRQ
 ||..... .||||||. .||..|||||||.|.  |||  |..| |. || .||| .  . . ||.. |...  .... . || . .|    .|.| .  
vdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvth

YHFISWPTHSTPRVSRPTLNFVKNIREEL-----------ESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSL
. |.||| . .|. .   |......||.            . .    |.|||| ||||||| ||.||| |..|. .. ||||. .| ..|  |   .|  
fqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle.evgtvdvvetvkllrtqrafsiqtp

VQYIFLHRALADFL
 || | . |. .. 
eqyefcylavleya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 796-992 7.4e-53 174.3 In-house 61-265 (270) alignment 
Range on Protein: 796-992
Range on HMM: 61-265/270.0
NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDP---TVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHFI
.....|||..||. .|...||||.||.. .||||.    | |..||..||| ...    . .||. |..|.|. .. . ..  ||.  .||| .  ... 
gekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyn

SWPTHSTPRVSR------PTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERtVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
.|| |. || .         |. ....|.  .. . ..||.||| ||.||||..||||| .. |. ... ||| |.....|..|. |||  .|| ||..|
tWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkk.vdvlaiieelRkdRmalvqhpeqyeflyka

LADFLQ
.. . .
vveyae
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 799-1001 6.1e-50 165.0 In-house 92-294 (297) alignment 
Range on Protein: 799-1001
Range on HMM: 92-294/297.0
QEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKeKCDKYWPINSDPTvFGKVIVTKLAEHTHDTWAVRDFRLKVGS--EERLIRQYHFISWPT
...|.|| || .|| .||.||....  .||||    |. | || .||. ..  | ||.| |. |. .       |.. .. |.   .|...||.|..||.
hrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPd

HSTPR--VSRPTLNFVKNIREELESPKlSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFLQGQ
.. .|    .  |......|.. .. . .|||.||| ||.|||||....|  . | | .| .||.| .| |.|.||  |||   || |.. |. ..|  .
kaverkdsassllklisevrkdfsqna.egPllvhclaGvGrtgvlltidsvvaeak.rekevdifglvkklrqerpylvqtkeqykfvyvavleallse

GHGVEVS
   ...|
dtriqas
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 789-987 3e-49 162.4 In-house 37-235 (237) alignment 
Range on Protein: 789-987
Range on HMM: 37-235/237.0
TMEFDGfnKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVG---SEERL
  .|||   |..|||.|||. .. ..||.|||.. |  ||||   ||| ..|| ||||   .|. .|.. |.   .     ..|| . | .     | ||
lkgfdg..tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrl

IRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHR
| ||.| ||| .  |. .   | | ||| .. .    ||| ..|| ||.||||.|. .| .|.. | ... ||..  |  .  .|  ..|.  ||.|.|.
ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak.ekkvvdiynyvysieedrpyiiqtkdqyvfihq

AL
..
ti
subfamily_PTPN13_pd Subfamily PTPN13 799-991 3.4e-48 159.3 In-house 77-269 (273) alignment 
Range on Protein: 799-991
Range on HMM: 77-269/273.0
QEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSD--PTVFGKVIVTKLAEHTHDTWAVRDFRLKV--GSEERLIRQYHFISW
 ||||.|||. .||..||.||||...  |.|.    |.|| ||..||| . .   .| ... |..|    .|...||.. .|    .| | . . .|..|
yeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkw

PTHSTPRVSRPTLNFVKNIREeLESpkLSGPLVVHCGAGIGRTGVFIALDILLQELKADErTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
| |..|. . . |.||...|. |..   .||.|||| |||||.|..|..|..|. .. |.  .||  .| |.|. | ..||.  |||| ..|. . |
PdhgvPssaaellqfvaevrr.lqt..dagPivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 792-991 1e-46 154.1 In-house 79-276 (515) alignment 
Range on Protein: 792-991
Range on HMM: 79-276/515.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPI-NSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYH
  .|.  . |||.|||   .| .|||.|....  .|.|. .  || | || ||||   .|   ||.. |  .. ..      | ...  |.. | . |.|
ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfh

FISWPTHSTPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
|  || . .|. ..  | ..|... .    ... ||..|| ||.|||||.|..|  . . | . |.|||| .| ..|..|  |||   || |.. |. . 
fteWPdkGvpkhtssllklikevkad..hgqythpliihcsaGvGrtGvvisidsvvahak.ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled

L
|
l
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 795-1007 1.4e-46 154.1 In-house 87-304 (325) alignment 
Range on Protein: 795-1007
Range on HMM: 87-304/325.0
FNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLvRCIEGGKEKCDKYWPIN-SDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGS--EERLIRQYHF
. | . ..|.| |...|....||.| . .|. .|.|   ...||..| .||| . ..   || . |   .  .   .  | . .|  .  | | ..|...
dkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfql

ISWP---THSTPRVSRPTLNFVKNIREELES-PKLSGPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
 ||.   ..  |    . |. ||.. | . .  | |.|..||| ||.|||||||.|  .|...  .   ||.| .| |.|..| |.|..  |||... ||
qswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviee.srvdifgfvkklrkdrpsmvetvdqyiliyeal

ADFLQGQGHGVEVSSIERSD
....      | |||.|   
veaymsgntdvpvssfeakl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 793-989 2e-46 153.2 In-house 85-281 (290) alignment 
Range on Protein: 793-989
Range on HMM: 85-281/290.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINsDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSE---ERLIRQY
.|... ..|||||||.|||. .||...|......||||.  || ||.|| .||| . | . .|.. .. | |.|...   | ...|  ..   .. . ||
kgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqy

HFISWPTHS-TPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALA
.. .|. .   .  .  .| . . .. .    .  ...|||| ...||..||.|... ..  |  |  .|||.|. ..|  .  .||. .|| .... . 
qitnwdstgkvtnpqtillvieemyktq..rkrgntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivl

D
 
t
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 791-992 6.6e-46 151.6 In-house 79-278 (315) alignment 
Range on Protein: 791-992
Range on HMM: 79-278/315.0
EFDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPI-NSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQY
 . .... . |||.|||   .| .|||||....  .|||.    || | || .|||  ..| . ||.. |. |  ..     .| . .. . | | . |.
yiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqf

HFISWPTHSTPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
.|  || . ... .   |...|... .    |   .|.||| ||.|||||.|..|  ....| ..|.|||| .| ..|..|  |||.  .| |.. |. .
qftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqik.rtrsvdvfnfvknlrakrpylvqteeeyafiydavle

FLQ
 |.
dll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 794-991 7.3e-46 151.2 In-house 75-277 (287) alignment 
Range on Protein: 794-991
Range on HMM: 75-277/287.0
GFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTH-DTWAVRDFRLK-VGSEE-RLIRQYH
.... ...||.|||.. || .|||.|.|..  ......| .| .. || |||| .  |   |   |. |        ..|| .||  . ..| |...|..
sytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqld

FISWPTHSTPRVSRPTLNFVKNIREELE---SPKLSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
..||| .. .  .   . || .... .|   . .  ||||||. .||||.|...|. .|.. |. |   ||| |||...|  | .|||. ||. .|  ||
llswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrle.dlGrvdvaavvirlreyraalvqavvqlrllyeal

ADFL
. . 
vtyy
subfamily_PTPN1_pd Subfamily PTPN1 799-987 1.2e-45 150.4 In-house 71-267 (290) alignment 
Range on Protein: 799-987
Range on HMM: 71-267/290.0
QEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSD--PTVFG--KVIVTKLAEHTHDTWAVRDFRLKV--GSEERLIRQYHFI
..|| ||||..|||  ||.||||... |.||| ...| .. || .||| . .    ..   |. |. ..|...... || ..|.     | | | ..|..
rsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyt

SWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADE--RTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
.||  . |.     |.|. ..||     .  || |.|| |||||.| |. .| .| .... .   .||.  |. ..|. |  |.|   |  | . |.
twpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 794-991 2.9e-45 149.3 In-house 70-267 (283) alignment 
Range on Protein: 794-991
Range on HMM: 70-267/283.0
GFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSdPTVFGKVIVTKLAEHTHDTWAVRDFRLKVG---SEERLIRQYH
  .. ..||..|.|. .|| .||.||....  ||||| .  |. ..|| .||| .     .|.  ||   | |.... .. . |.|     .. |.  | 
sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyq

FISWpTHSTPRVSRPTL-NFVKNIREELESPKlsGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL-A
.| | ..  .     .| .| | |    ||.|  ||.|||| .|||||.||||.   ...... |  |||||||  || .|  .||.| || ..| .   
vidW.leygeqaiinslvkfnkvislqteskk..gPivvhCstgiGrtavfiaasasvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhelvle

DFL
. |
qal
subfamily_PTPN14_pd Subfamily PTPN14 798-992 2.5e-44 146.5 In-house 92-297 (300) alignment 
Range on Protein: 798-992
Range on HMM: 92-297/300.0
PQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPIN---SDPTVFGKVIVTKLAEHTHDTWAVRDFRLK--VGSEERLIRQYHFI
 ..||..|||. .||..||.||||..   |||| . .|.||||. ||.| .    .   |||  ||.   .. |. . . ..||    .||| .    ..
ersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqyt

SWPTHSTPRVSRPTLNFVKNI---REEL----ESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERtVDVFAVVAKMRRERCSLVQSLVQYIFLHR
 || |  |.  .. |......   |..     || . . |..||| ||.||||| |  |.|.. |. .|. .|.  |.|..|. | .|||.| || |...
DWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehnee.idikkvlarLreqrmllvqtlaqYkfvYk

ALADFLQ
.|  .|.
vlikylk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 792-992 2.8e-44 146.2 In-house 79-279 (287) alignment 
Range on Protein: 792-992
Range on HMM: 79-279/287.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDpTVFGKVIVTKLAEHTHDTWAVRDFRLKVGS---EERLIRQ
 ||... ...|....||.||. .||....... .|||||..  |  .|.| .||| ..  .|.|.  .. | |.... . .|....|  .   ... ..|
idgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkq

YHFISWPTHS-TPRVSRPTLNFVKNIREELESPKlsGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
|.. .|. .   ..     | . . ....  . .  ...|||| ...||...|.| .. ... |  | ..||| |. ..|  .   ||   ||.|.  ..
yqitnWdstgkvtepqtillvieemyktqrkrgn..tsivvhCsdtvGrsamfcaaattinkckt.eGviDvfqvlksqriqkpgsvqtveqykfindiv

ADFLQ
  .|.
leyld
subfamily_CG7180_pd Subfamily CG7180 790-989 2.9e-44 145.9 In-house 76-288 (296) alignment 
Range on Protein: 790-989
Range on HMM: 76-288/296.0
MEFDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKeKCDKYWPINSdPTVFGKVIVTKLAEHTHDTWAVRDFRLKVG---------
 . |.| |..||| |..|. .||.||||.|...|. |.|.| .  .  | .. .||| .|  . .|...|  . |..      | |.|.           
vyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqek

---SEERLIRQYHFISWPT-HSTPRVSRPTLNFVKNIREELESP---KLSGPLVVHCGAGIGRTGVFIALDILLQELKADErTVDVFAVVAKMRRERCSL
    |.|.......  |.  .. | ..   ..... .|   |     .  ||.||..  | .|.||..|.|. |. .. .|  ||||  | ..||.|  |
qvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekee.evdvFeavktlrrsRpqL

VQSLVQYIFLHRALAD
|..  .| ..   | .
venveeYkyiYdvlle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 785-991 3e-44 146.2 In-house 76-279 (439) alignment 
Range on Protein: 785-991
Range on HMM: 76-279/439.0
QHKFTMEF-DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKekcdkYWPINsDPTVFGKVIVTKLAEHTHDTWAVRDFRL----KV
 | .. .. .|. ... |||||||  .|...|||.|.|| .  ||||   .|  |     ||| . . ...| ..|    .     ...| |..      
shyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd.aevcygdiavrvdrnielpnyvirgfkvfnerdt

GSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREELESpKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERtVDVFAVVAKMRRERCSLVQSLVQ
.  || . |.|.|.|| .  |  .   |.|.. |    .. .  ||.|||| ||.||||  ||||| |..||.... ||.  .|  .|..|  .||.|.|
tekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlklenk.vdikgivkvlrkqrkqmvqalcq

YIFLHRALADFL
|.|.. |. . .
yvfiynavledi
subfamily_PTPRN_pd Subfamily PTPRN 799-989 2.1e-43 143.1 In-house 100-290 (297) alignment 
Range on Protein: 799-989
Range on HMM: 100-290/297.0
QEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSdPTVFGKVIVTKLAEHTH-DTWAVRDFRLKV--GSEERLIRQYHFISWP
  |||||||...|| .||.||||. .  ||.| |  | | ..|..||| .    |..   |  ..||   | . || | ||    || | . |.||.|||
payiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp

THSTPRVSRPTLNFVKNIREELESpkLSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
 ...|  ... |.| . .         | |.|||| .| |||||.|..|..|. |.   . .|. | . ..| .|  ||..  |. |   |.|.
eegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0051429 (Phosphotyrosine protein) phosphatases II 796-991 4.5e-42 139.9 In-house 19-225 (272) alignment 
Range on Protein: 796-991
Range on HMM: 19-225/272.0
NKPQEYIATQGPMSNTVHEFWRMvWEKECPAIVMLVRCIEGGKEKCDKYWP-----------INSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK---VGS
 ||  .....||. .|...|||. .|  . .||.| .. | |..|||.|||               .  .|.. || | |.... . .| ..|.     .
vkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

EERLIRQYHFISWPTHSTPRvsRPTLNFVKNIREelespklSGPLVVHCGAGIGRTGVFIALDILLqELKADERTVD--------VFAVVAKMRRERCSL
| | ....|...||.|..|.   . |.... ...       .||..||| ||..|||...||..|| .   .|  ||        ....|...|. |   
earevmhlhytdwpdhgvpq..eallellellld.......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpga

VQSLVQYIFLHRALADFL
||.  ||.||..||...|
vqteeqylflyeallell
subfamily_PTPN23_pd Subfamily PTPN23 800-986 2.3e-40 133.2 In-house 84-275 (288) alignment 
Range on Protein: 800-986
Range on HMM: 84-275/288.0
EYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSD-PTVFGKVIVTKLAEHTHDTWAVRDFRLKVG--SEERLIRQYHFISWPT
..||||.|. .|. .||.||.|.  . ||||.   | ||.|.|.||| . . ...||.. ||   ... .|.  |...|..   .. . ..  .. ||| 
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

HSTPRVSRPTLNFVKNIRE--ELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
.  |      |.|......  | .  |.  |||||| ||.||||||  .   ..||....  .|.  || ..|..|   ||   |. |.  |
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 790-987 6.1e-40 131.9 In-house 44-236 (239) alignment 
Range on Protein: 790-987
Range on HMM: 44-236/239.0
MEFDGfnKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPtvFGKVIVTKLAEHTHDTWAVRDFRL-KVG-SEERLIR
 ..||   |. |||||| .. .  .||||.|..    ||||   ||| |.|| .||| ..    . .. ||         . .| | . .|| .||| . 
rdydg..spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqteeryvy

QYHFISWPTHSTPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
||||  || .  |. .   | . ..| ..  |   . | |.|| ||.|||| |. .| .|.. |  ..|||.|  |  .| .|  .||.  ||.|.| |.
qyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 790-987 6.9e-40 131.7 In-house 45-237 (239) alignment 
Range on Protein: 790-987
Range on HMM: 45-237/239.0
MEFDGfnKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPtvFGKVIVTKLAEHTHDTWAVRDFRL-KVG-SEERLIR
 ..||   |. |||||| .. .  .||||.|..    ||||   ||| |.|| .||| ..    . .. ||         . .| | . .|| .||| . 
rdydg..spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqteeryvy

QYHFISWPTHSTPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRAL
||||  || .  |. .   | . ..| ..  |   . | |.|| ||.|||| |. .| .|.. |  ..|||.|  |  .| .|  .||.  ||.|.| |.
qyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlav
0036282 (Phosphotyrosine protein) phosphatases II 793-984 4.3e-39 129.3 In-house 11-163 (174) alignment 
Range on Protein: 793-984
Range on HMM: 11-163/174.0
DGFNKPQEYIATQGPMSntvheFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPInsdptvfgkvivtklaehthdtwavrdfrlKVGSEERLIRQYHFI
|..  . ..||.|||..     ||.|..|  . ..||| ...| |..||  |||                               .  ..|||. ||...
dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredlerlgiqylyl

SWPTHSTPRVSRpTLNFVKNIREELESpKLSGPLVVHCGAGIGRTGVFIALDILLQELKadERTVDVFAVVAKMRRERCSLVQSLVQYIFLH
 || |..| .|   |.||| ..| |.. . .||..||| ||.||||...|....|. |.  |..||....|...|. |.  ||.  ||.||.
pwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 791-992 1.8e-38 127.0 In-house 77-294 (301) alignment 
Range on Protein: 791-992
Range on HMM: 77-294/301.0
EFDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPI-NSDPTVFGKVIVTKLAEHTHDTWAVRDFRLKV--GS------
  ||... ...||.|||| .|. .|||..|..   .|||.    || |.|| .|||  . . . ||.. ||   |...  . .|.. .|.  ||      
yidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyie

---------EERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPKlSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCS
         . . . |.. ..||..   |  |  |. . ..     ..   ||.|||| ....|.||.....| |   || |  |||| |.  .|| .  
rkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpg

LVQSLVQYIFLHRALADFLQ
 |. | ||.... ..  .||
aVtTLeqytsiydvidmylq
0049260 (Phosphotyrosine protein) phosphatases II 793-984 1.8e-37 123.7 In-house 3-143 (152) alignment 
Range on Protein: 793-984
Range on HMM: 3-143/152.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWpinsdptvfgkvivtklaehthdtwavrdfrlkvgseerlirQYHFI
||...|.|.||||||..||. .||||..|  . .|||| .. | ||.||..|.                                          ||...
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhl

SWPTHSTPRVSRPTLNFVKNIREEleSPKLSGPLVVHCGAGIGRTGVFIALDILLqelkadeRTVDVFAVVAKMRRERCSLVQSLVQYIFLH
 || |..|  |   | ... |..     . .|| .||| ||.||||...|....|       . |... .|| .|. |   |..  |..||.
pwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
0041856 (Phosphotyrosine protein) phosphatases II 792-993 1.4e-36 121.1 In-house 27-173 (182) alignment 
Range on Protein: 792-993
Range on HMM: 27-173/182.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVrcieggkekCDKYWPinsdptvfgkvivtklaehthdtwavrdfrlkvGSEERLIRQYHF
..|  .....||||||. .|| .|.||..|  . .||.|          .. |||                                   .|||. ||..
ylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.................................ellerlgiqyly

ISWPTHSTPRvSRPTLNFVKNIREelespkLSGPLVVHCGAGIGRTGVFIALDILLQElkaderTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
..|| |..|   . .|.|.. ..|       .|| .||| ||.||||...|......        |... .|. .|. |.  |... ||.||..|| ..|
lpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavklvrsrRpgmvitpnqyfflqlallell

QG
..
ll
0046846 (Phosphotyrosine protein) phosphatases II 800-988 7.1e-36 118.9 In-house 24-170 (176) alignment 
Range on Protein: 800-988
Range on HMM: 24-170/176.0
EYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVfgkvivtklaehthdtwavrdfrlkvgseerlirQYHFISWPTHST
 .||||||. .|. .|..|..|  . |.|.|  ..| |. ||. |||.  .. .                                  ||... || |..
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..................................qylhlpwpDhgv

PRVsRPTLNFVKNIREELESPklsGPLVVHCGAGIGRTGVFIALDILLQelkadERTVDVFAVVAKMRRERC-SLVQSLVQYIFLHRALA
|   .  |.... ||| |..    || .||| |||||||...|...|       |. ..|. ..|..|. |.   ||.  || ||.... 
pdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgavqtpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 793-984 1.8e-35 117.5 In-house 14-154 (172) alignment 
Range on Protein: 793-984
Range on HMM: 14-154/172.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCieggkekcdkywpinsdptvfgkvivtklaehthdtwavrdfRLKVGSEERLIRQYHFI
|.  .|...||||||..||...||||..|. . .||.| ..                                           .    .|||. ||...
dlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpellerlgiqylyl

SWPTHSTPrVSRPTLNFVKNIREELeSPKLSGPLVVHCGAGIGRTGVFIALDILLqelkadeRTVDVFAVVAKMRRERCSLVQSLVQYIFLH
.|| |..|  ..  |.|.. |.| |   . .|| .||| ||.||||...|....|       . .... .|| .|. |.  ||.  ||.||.
pwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 800-990 2e-35 116.8 In-house 95-282 (290) alignment 
Range on Protein: 800-990
Range on HMM: 95-282/290.0
EYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS-DPTVFGKVIVTKLAEHTHDTWAVRDF---RLKVGSEERLIRQYHFISWP
 .| |||.. .|| ..|||| ...  |||||   || || ||..|.| .. .   ||.. |.   |...|.  ..     | |    |  .. .. .|||
mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp

THSTPRVSRPTLNFVKNIReelespKLSGPLVVHCGAGIGRTGVFIALDILLQELkADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
 .| .  .   |  .. .|      |.|||.|||| ||||||| |.|... || |  | . .|.  .|  .|. | . ||  .||. | ..| |.
dksvalstlallrtlrilr......kasGpvvvhcsaGiGrtGtfvaievglqil.ldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 796-990 5.4e-35 115.9 In-house 79-276 (307) alignment 
Range on Protein: 796-990
Range on HMM: 79-276/307.0
NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS-DPTVFGKV----IVTKLAEH----THDTWAVRDFRLKVGSEERLI
 ||. .|..|||. ||...|| |. ...  ...||...|| .| ||..|||..  .  |||.      |..|  .     .|   | ..... ... | |
ikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrti

RQYHFISWPTHSTPRVSRPTLNFVKNIREElespklSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
... .  || . .|..   ..|... .| .        |.|||| ||.||.|  .|. .. . . | .   |.  .| ..| .|   .|. .||..||| 
qhlqwenwpdrgvpqinltainlleavryd......tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv

LADF
| ..
lley
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 791-989 7.3e-34 111.8 In-house 80-234 (392) alignment 
Range on Protein: 791-989
Range on HMM: 80-234/392.0
EFDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGkekcdkywpinsdptvfgkvivtklaehthdtwavrdfrlkVGSEERLIRQYH
 ...|.  . |||.||| . ....|||||....  .|.|. .  ||                                           | . | . |.|
yipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfh

FISWPTHSTPRVSRPTLNFVKNIREELesPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
|  || .  |. .   |.|.|... .    . . ||..|| ||.||||| |..| ..   |   | |||| .|...||.|  .||.  || |.. |. .
ftewPdkdvpkhtssllkfikevkadf..Gqythpliihcsagvgrtgvvisidsvvahakk.trmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 742-990 2.3e-33 110.1 In-house 32-268 (281) alignment 
Range on Protein: 742-990
Range on HMM: 32-268/281.0
FNDNHNNSSNrhpRHSKAPPLILSRPILSSQFPlhyNEMVADKQHKFTMEfDGFNKpQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKC
||.  ||  |   |... | | .||  |  ..|   |.  .|  |   .    | | . || ||||  .|  .||||.|...  |||||.. .|  .|||
fnqpvnnkkn...rylnipcldisrvqlkvkmp...nknstdyihanyir.spflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekc

DKYWPINSDPTV-FGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREElespklSGPLVVHCGAGIGRTGVF
 .|.| |.   . | |. |.        .     . |    | ||| .. .  ||    |  |   |. ...||        | | |.|| ||.||.| .
aeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar......stppvihcsagvgrsgtl

IALDILLQELKADERTVDVFAVVAKMRR-ERCSLVQSLVQYIFLHRALADF
.|..| || ...     |.  .|...|   |.. ||.| ||... . | ||
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 792-993 6.6e-31 102.3 In-house 65-261 (267) alignment 
Range on Protein: 792-993
Range on HMM: 65-261/267.0
FDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCiegGKEKCDKYWPIN-SDPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEE-RLIRQY
 .|... . .|.||.|..||. .|. .. ....| ||.| .    ....  ..|| .  .   .  . | .  |.  . . .  . ||.  |  . .  |
vegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtly

HFISWPTHSTprvSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
..  |   .     .| |. .  |  . .  . . ||||.| .|.||.| |. .|  |. .|  | ..|.|  . |.|  | .||... .||..|. ||.
yykkwnintn...nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakt.egvsdifdflrkirsqriglvdtkeryiyihellae

FLQG
. .|
yaeg
0049772 (Phosphotyrosine protein) phosphatases II 793-996 1.1e-30 102.9 In-house 81-285 (314) alignment 
Range on Protein: 793-996
Range on HMM: 81-285/314.0
DGFnkpQEYIATQGPMSNTVHEF----------WRMV--WEKECPAIVM---------------------LVRCIEGGKEKCDKYWPINSdptvfgkviv
|||   . .||||||...||. |          ||||  ..  .  |||                     | .. ..| | . ....             
dgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk..........

tklaehthdT-------WavrdfrlkvgseERLIRQYHFISWPTHSTPrVSRPTLNFVKNIREElespKLSGPLVVHCGAGIGRTGVFIALDILLQELKa
         .       .            |||. .|. | .| .|.|  ..  . |.. |.|     .  ||..||| ||.||||.|.....|.  |. 
.........eelydpelf............erlgikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg.

dertVDVFAVVAKMRRERC-----SLVQSLVQYIFLHRALADFLQGQGH
    |..  ... .|. |      .....| ||.| ..|| ..|. . .
....vsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
PTPc_DSPc_SM00012 886-988 1.6e-30 100.8 In-house 2-104 (105) alignment 
Range on Protein: 886-988
Range on HMM: 2-104/105.0
IRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHR
...||. .|| |..|. | . |......... .  . |.|.|||| ||.||||.|.||||||| |.. ...||.| .| ..|..| ..||.. ||.||.|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALA
||.
all
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 800-990 2.2e-29 97.1 In-house 97-288 (305) alignment 
Range on Protein: 800-990
Range on HMM: 97-288/305.0
EYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSD--PTVFGKVIVTKLAEHT----HDTWAVRDFRLKV-GSEERLIRQYHFI
 .|..|||. .|. ||| || ..    ||||.. .| || || .|||.      .. . ..| ...            .  ..|   |...  .|. .. 
rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwt

SWPTHSTPRVSRPTLNFVKNIREElespklSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
 ||    | .   .|...  ||          |.|||| |||||||  .|.. .|...  . .   .  .|  .| .|.  .|. |||.|.|| . ..
ewpdrgvppckltslellsairgs......kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_ptpA1_pd Subfamily ptpA1 796-951 2.6e-28 93.9 In-house 86-257 (418) alignment 
Range on Protein: 796-951
Range on HMM: 86-257/418.0
NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS----------DPTVFGKVIVtKLAEHTHD---TWAVRDFRLKVGSE
  |...|.||||. ||. .|||||||. |  |||| |  |  . |||.||| .              |||   | .| |  .|       |. || .  |
aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysv.elveviqdpereiitrnirltfege

ERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREE----LESPKLSGPLVVHCGAGIGRTGVFIALDILLQELK
 | | ||..  || |  |  ..|  .....| .     . |     |..||| ||.|||| | .  |....| 
trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 797-991 1.1e-27 91.8 In-house 80-271 (288) alignment 
Range on Protein: 797-991
Range on HMM: 80-271/288.0
KPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS-DPTVFGKVI-VTKLA-EHTHDTWAVRDFRL-KVGSEERLIRQYHFI
 ..  | .| |.  |. |.|.|. |..   |||| . .| |||| ..|.| .  . . .|..  |.|   .  . .  |  .|  |.| |. .... |. 
ykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhll

SWPTHSTPRVSRPTLNFVKNIreelesPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADErTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
 |. .. |    . |.... .       .|  |.|||. ||.|||| .|   | |. |. |.  . .  ..||.| ||   .|.  ||...|| . . |
eWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrldd.flgirsllaklreerfkaiqtemqylyvhrcvleel
0044763 (Phosphotyrosine protein) phosphatases II 800-986 2.5e-27 91.1 In-house 30-166 (178) alignment 
Range on Protein: 800-986
Range on HMM: 30-166/178.0
EYIATQGPmsntvHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDptvfgkvivtklaehthdtwavrdfrlkvgseerliRQYHFISWPTHST
 |.....|      .......|  . .||.|   .|.|..|||.||| . .                                     ||..| .| |..
lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag....................................iqylhipipDhgv

PRVSRPTLNFVKNIREELESPKlsGPLVVHCGAGIGRTGVFIALDILLQElkaderTVDVFAVVAKMRRERCsLVQSLVQYIFLHRA
| ... .|.||. |.| |....  || .||| ||.||.|...|......        ........ .|. |.  |..  |. .|.. 
pdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivpnpgqlrqLyef
0051082 (Phosphotyrosine protein) phosphatases II 801-986 3.4e-27 90.3 In-house 15-148 (151) alignment 
Range on Protein: 801-986
Range on HMM: 15-148/151.0
YIATQGPMSntvhEFWRMVWEKECPAIVMLVRCIEGGkeKCDKYWPINSdptvfgkvivtklaehthdtwavrdfrlkvgseeRLIRQYHFISWPTHSTP
.....||..    .|.....|  . .||.|    | |  .| .|.| ..                                  . ........||....|
lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................ievlhipildwpdpglp

RVSRPTLNFVKNIREelespKLSGPLVVHCGAGIGRTGVFIALDILLQElkadertVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
      |.|.. ...     | .||..||| ||.||||...||...|.        |....... .|. |. .||.  |..|...|
lsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 797-993 5.3e-27 89.3 In-house 86-289 (305) alignment 
Range on Protein: 797-993
Range on HMM: 86-289/305.0
KPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTV-F---G-KVIVT----KLAEHTHDTWA-VRDFRLKV---GSEE
.|. .| || |. .|  .|| | ...   || ||   .| | .|| .|.. . .... |   | |..|     .  . ..|. | |..  | .   |.. 
npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgeka

RLIRQYHFISWPTHSTPRVSRPTLNFVKNIReelespKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFL
| . .||.| ||    |      |..... |       . ||.|||| |||||||  . |. .|..| | .   |   .. |.| .|   .|.  ||.|.
rkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv

HRALADFLQG
|. . .... 
hqvilnyfrk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 799-984 8.2e-27 88.7 In-house 4-196 (198) alignment 
Range on Protein: 799-984
Range on HMM: 4-196/198.0
QEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEgGKE-KCDKYWPIN-SDPTVFGKVIVTKLAEHTHDTWAVRDFRLK----VGSEERLIRQYHFI
. ||||| |. .|. .||.||||     |||.       ||     |||   |  . .| . ||  .  |.  ...  . |          | | .| | 
rryiatqhplretladfwqmvwetgsghivmvnddqk.nkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPTHSTPRVSRpTLNFVKNIRE---ELESPKlSGPLVVHCGAGIGRTGVFIALDILLQELK-ADERTVDVFAVVAKMRRERCSLVQSLVQYIFLH
||  ..|| |.   . ||   ||     |  |   |..|||  | | ||||.|||| ..  . .    ||.| |  ..|. || .. || .| |..
swkekttpnval.fvgfvvasrevskkyeqek.dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 799-984 8.6e-27 88.6 In-house 5-197 (199) alignment 
Range on Protein: 799-984
Range on HMM: 5-197/199.0
QEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEgGKE-KCDKYWPIN-SDPTVFGKVIVTKLAEHTHDTWAVRDFRLK----VGSEERLIRQYHFI
. ||||| |. .|. .||.||||     |||.       ||     |||   |  . .| . ||  .  |.  ...  . |          | | .| | 
rryiatqhplretmadfwqmvwetgsghivmvnddqk.nkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPTHSTPRVSRpTLNFVKNIRE---ELESPKlSGPLVVHCGAGIGRTGVFIALDILLQELK-ADERTVDVFAVVAKMRRERCSLVQSLVQYIFLH
||  ..|| |.   . ||   ||     |  |   |..|||  | | ||||.|||| ..  . .    ||.| |  ..|. || .. || .| |..
swkekttpnval.fvgfvvasrevskkyeqek.dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 786-996 3.2e-26 86.9 In-house 63-275 (285) alignment 
Range on Protein: 786-996
Range on HMM: 63-275/285.0
HKFTMEFDGFNKpQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPT-VFGKVIVTkLAEHTHDTWAVRDF------RL-
|   | . | ..   ||.||||. .|. .||.|.....   ..||.  .||| |||  |.| .      |||  .| |.|   .. |   .         
haswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeit.lteckeeaiagtilnaltvinte

KVGSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREEleSPKlSGPLVVHCGAGIGRTGVFIALDILLQELKaDERTVDVFAVVAKMRRERCSLVQSL
   ||   . . .   || . .|  .|| ... | ...    ||   |..||| ||.|||  |. .|     .  ..  .... .| .||  |   ||| 
dasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npk.ekpicvhcsagvgrtatfvgidyatirim.enpniemldivremramrfqavqsh

VQYIFLHRALADFLQGQGH
.|..||.  | ... |.| 
mqflflyvvlmeyfigegv
subfamily_egg_pd Subfamily egg 799-992 3.2e-26 86.7 In-house 83-271 (307) alignment 
Range on Protein: 799-992
Range on HMM: 83-271/307.0
QEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGgkEKCDKYWPI-NSDPTVF--GKVIVTKL--AEHTHDTWAVRDFRLkVGSEERlIRQYHFIS
 |.| .| |. |||..|||||...|.. ||||    |   |.|. |||  .||. |.  | . .. |   ...   . |  ..| ||...   |      
nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgdde.erflehwq

WPTHSTPRVSRPtLNFVKNIReelespKLSGPLVVHCGAGIGRTGVFIALDILLQEL-KADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFLQ
.  . .  |  | |. .. .|      .|| | ||..  |. ......|..| | .| .       |   |  .|..|   |.| ..|.|..| .. |..
gdvnnssdvysp.lrvlrklr......nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 797-981 3.7e-26 86.6 In-house 88-271 (301) alignment 
Range on Protein: 797-981
Range on HMM: 88-271/301.0
KPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTV-FGKVIV--TKLAEHTHDTWAVRDFRLKVGSE---ERLIRQYH
.|. .||||||..|| ..|| |.   .   |||| . .|  .|||..| |..   ..  |.  .  ..     ..    | ....  ..    | .  | 
hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyq

FISWPTHSTPRVSRPTLNFVKNIREeleSPKlsgPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYI
. .|. . .|.    . .... ...   | |   |.|||| |||||.  ||. ..| .|..|| .|...   ....| .| . ||   |  
ysewtdrgvPkshaelfdlmelvkk...sek...PivvhcsaGiGrsvafigteylarevead.ptieltealkhlrehrwngvqtnsqly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 880-993 1.1e-22 75.0 In-house 85-197 (440) alignment 
Range on Protein: 880-993
Range on HMM: 85-197/440.0
GSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREELESpKLSGPLVVHCGAGIGRTGVFIALDILLQELKADErTVDVFAVVAKMRRERCSLVQSLVQ
| | | ..|||. .|| .. |... | |...... |  |    .|||.||| || ||||| ||.| .|.| |  .  .|.|...  || .|  .||.  |
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.agngpllvhcsagagrtgviiavdsilreakrsd.qidifsfinsmrnnrpqmvqtpeq

YIFLHRALADF-LQG
| |.| |. .  | |
yafvheavlegllcg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 800-995 1.3e-22 74.8 In-house 95-294 (310) alignment 
Range on Protein: 800-995
Range on HMM: 95-294/310.0
EYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIVTKLAEHTHDT----WAVRDFRLKVGSEERLIR----QYHF
 .| .|||.  |. .||||.... . .|..|..  | |. ||  |||       .| . ||.|.| ...      ||     .|  .|.       .  .
tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvsl

ISWPTHSTPRVsrPTlNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADErTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
| ||      |  |  . .. . . | .    || |||| ||..|..| .||.. .. |.  .  ||.  |.......|   .|. .||....|    | 
ikwpnwpdrgv..pd.ekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrgl.kvdaeevktellksraiciqtelqyliidrvriifa

QGQG
.|. 
rget
0048076 (Phosphotyrosine protein) phosphatases II 865-987 5.1e-22 73.5 In-house 26-139 (145) alignment 
Range on Protein: 865-987
Range on HMM: 26-139/145.0
HTHDTWAVRDFRLKVGSEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPklsGPLVVHCGAGIGRTGVFIALDILLQelkadeRTVDVFAVVA
. .. ..| ..      .|||. ||....|| |..|  ..  |.|.. |.| |...   || .||| ||.||||...|....|.      . |... ...
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll......lgvsleeale

KMRRERCSLVQSLVQYIFLHRAL
..|. |   |..  |..||....
lvrsqrpgavpnpgqlrflyefe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 796-901 9.7e-22 72.2 In-house 73-181 (297) alignment 
Range on Protein: 796-901
Range on HMM: 73-181/297.0
NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS-DPTVFGKVIVTKLAEHT--HDTWAVRDFRLKVGSEERLIRQYHFI
...  || .|||.|.||..||..|.|..  .|||. .  |.|..||  |||    .    |.|.|  |.. .  .|.  . ...|   ||.| .|   |.
eadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqfl

SWPTHSTPR
||| |  | 
swpdhGvps
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 796-995 1.8e-21 71.2 In-house 79-280 (312) alignment 
Range on Protein: 796-995
Range on HMM: 79-280/312.0
NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPI------NSDPTVFGKVIV-TKLAEHTHDTWAVR--DFRLKVGSEERLI
 ||. ...||||. ||.  ||...    . .|..|.  .| | ||| ||           |  |. .     ..  ...|  . |     .|   .|  .
tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqeskl

RQYHFISWPTHSTPRVSRPTLNFVKNIREElespklSGPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
 .| . ||| |  |     .| ..  .. .        |.. || ||.|||| .. .. ..  |.   |  .|  .   .|..|.  |. . ||..  |.
nhyqwaswpdhgmpdscdtalrllsavkkd......kkpviahcsagvgrtgtlaliesmiaalrh.prkqnvkdsfvllrkdrarsvrvfpqyvyalrc

LADFLQGQG
. .||  .|
vleflyskg
0048179 (Phosphotyrosine protein) phosphatases II 881-985 2.4e-20 68.2 In-house 44-139 (144) alignment 
Range on Protein: 881-985
Range on HMM: 44-139/144.0
SEERLIRQYHFISWPTHSTPRVSRPTLNFVKNIREELESPklsGPLVVHCGAGIGRTGVFIALDILLqelkadERTVDVFAVVAKMRRERCSLVQSLVQY
..|| . ||....|| |..|  .   |.|.. |.| ||..   || .||| ||.||||...|.....      .. .... ..| .|. |.  |..  |.
fleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnpgql

IFLHR
.||..
rfLle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 798-991 2.4e-19 64.4 In-house 27-221 (255) alignment 
Range on Protein: 798-991
Range on HMM: 27-221/255.0
PQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDP-TVFGKVIVTKLAEHTHDTWAVRDFRLKVG--SEERLIRQYHFISW
|.     .   | || .|....  ..   .|||    | |.|||..|.|.. |   .. .| ||     ..     ..  ...|   . . .. |..  |
PekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGW

PTHSTPRVSRPTLNFVKNIREelespklSGPLVVHCGAGIGRTGVFIALDILLQ----ELKAD-ERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
. . .|. .|  || .| .|.       | ..|||| .||||.  |.  ... |     |.      .|   .. ..| .| . ..  .|  |    . |
ieknaPelareilnilkvvrd.......sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

FL
..
lv
subfamily_eak_pd Subfamily eak 798-992 8.1e-19 62.2 In-house 92-306 (332) alignment 
Range on Protein: 798-992
Range on HMM: 92-306/332.0
PQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS-DPTVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERLIRQYHFISWPT
 ..|| |  .  . |  ||.|| |.  ||||.|.  .| . || |||.| .. .   ||.. |..     ..   .| . |..| |   .  |..  |  
GrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwte

HSTPRVSR-------------PTLNFVK------NIREELESPKLSGPlVVHCGAGIGRTGVFIALDILLQELKA---DERTVDVFavVAKMRRERCSLV
 ..|..               . |  .|       ..    .|    | .. .  |  |.|||. .|.|.. . .   .  .|. .  . |..  |   |
ttlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedl..ilkvkskrihsv

QSLVQYIFLHRALADFLQ
    |. |.. .. |.|.
lvalqhsfiyeivldyll
subfamily_CG42327_pd Subfamily CG42327 922-990 7.2e-18 59.3 In-house 246-314 (319) alignment 
Range on Protein: 922-990
Range on HMM: 246-314/319.0
LSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
  |||||||  |.||||. || || ...|.  .|.||.  .|  .||.|.| |..  || |... |  .
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 802-991 4.5e-17 56.4 In-house 93-285 (302) alignment 
Range on Protein: 802-991
Range on HMM: 93-285/302.0
IATQGPMSNTV---HEFWRMVWEKECPAIVMLVRCIEGGKeKCDKYWPI-NSDPTVFGKVIVT-KLAEHTHDTWavRDFRLKV----GSEERLIRQYHFI
| .| | ....    ||||||.....  .|.||.  |  |   ....|    | . .||. |  .  |.....     . . |     |.  |.  |.. 
ilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvlt

SWPTHSTPRVSRPTLNFVKNIreELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADeRTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
 |. .. |     . . ....    .. | . ..|.    |.|| |.|..| . ...|...   . .  .|...| .|.. |.|| ||..|..||. ..
nWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_hpo-7_pd Subfamily hpo-7 808-990 2.2e-16 54.5 In-house 43-226 (263) alignment 
Range on Protein: 808-990
Range on HMM: 43-226/263.0
MSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPT-VFGKVIVTKLAeHTHDT-WAVRDFRLKVG--SEERLIRQYHFISWPTHSTPRVS
. .|...|....  ..   .|||    | |.|||..|.|.. |   .. .| |.      .|.    ...   .|   . . ...| .  |. .  |. .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttk.vqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

RPTLNFVKNIREelespklSGPLVVHCGAGIGRTGVFIALDILLQ----ELKAD-ERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADF
|  || .|  |.       | .||||| .||||.  |   ... |     |.      .|   .. ..| .| . ..  .|  |    . ||
reilnilkvarn.......skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_CG42327_pd Subfamily CG42327 797-919 1.1e-15 52.2 In-house 70-196 (319) alignment 
Range on Protein: 797-919
Range on HMM: 70-196/319.0
KPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINS---DPTVFGKVIVTKLAEHTHDTWAVRDFRLKV--GSEERLIRQYHF
 |  |||.| .. ..  .|||.|||.    || |.   | | ..| .|.| .    .  ..|.. ||     ..| .|.  . ||   ..| | .  | .
apnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy

iSWPTHSTPRVSRPTLNFVKNIREELES
  |.    |   .. .  . ..|. |.|
.kwleaevPaeeaaliamllevrsslks
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 796-996 1.9e-14 48.0 In-house 80-284 (303) alignment 
Range on Protein: 796-996
Range on HMM: 80-284/303.0
NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDPTVFGKVIV--TKLAE-HTHDTWAVRDFRLKVGSEERLIRQYHFI
.  .  | || |.| |  .||.|. |.    ...|.   |  |   |  .| | |   | .  .   .. .    | |...   .  |.   ..  .|. 
dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk

SWPTHSTPRVSRPtlNFVKN---IREELESPKLSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALAD
.||  | |  . |  .|||.   ..  |     | | |    .| ||.| |  ..     |.... ..|.  .. ..|  |   || | |. ...  ||.
awphnsipsdgsp..kfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

FLQGQGH
 . ..| 
hvldngi
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 803-984 2.1e-14 48.4 In-house 64-252 (290) alignment 
Range on Protein: 803-984
Range on HMM: 64-252/290.0
ATQGP-------MSNTVHEFWRMVWEKECPAIVMLVRCIEGGKE----KCDKYWPINSDP-TVFGKVIVTKLAEHTHDTWAVRDFRLKVGSEERL-IRQY
.|| |          |. .|| |. . .   .|||    |  ..     | || | . .    |. . |      ..|   .|   .| . || . .  .
ltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHs

HFISWPTHSTPRVSRPTLNFVKNIREElespklSGPLVVHCGAGIGRTGVFIALDILLQELKADERTVDVFAVVAKMRRERCSLVQSLVQYIFLH
 . .| . .... ..  |. ..... .        | .|||  || |  .. |...  | .   .  | . .|. ..|..|  ...|  .. |  
llkgWnklnvqedtktllsliqkvkas......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 805-983 2.2e-14 47.6 In-house 97-280 (302) alignment 
Range on Protein: 805-983
Range on HMM: 97-280/302.0
QGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPINSDP-TVFGK------VIVTKLAEHTHDT-WAVR-----DFRLKVgSEERLIRQYHF
  |  .|.  .| .. . .   .| |.  .|....|| .|.  . .    ||.       . |.|.| |      .      . . |    .. .   .|
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilaf

ISWPTHSTPRVSRPTLNFVKNIreelESPKLSgpLVVHCGAGIGRTGVFIALDILLQeLKADERTVDVFAVVAKMRRERCSLVQSLVQYIFL
 .|| | .|. . ..|. .|      || | .  ..||| ||.|||| ..|.   .| | . ... |.  .|  .|. |   ||.  | |.|
sawpdhGapkeaytaldilkfc....esykkn..vlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 779-888 2.6e-14 47.4 In-house 217-322 (440) alignment 
Range on Protein: 779-888
Range on HMM: 217-322/440.0
EMVADKQhKFTMEFDGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEggkEKCDKYWPINSDPTVFGKVIVTKLAEHTHDTWAVRDFRLK
.  .||   .  ||.|. | . .|||| |.  || .|||.| . .  .|.|| .  .     |  |||.|.    ||   | .      .   || . ||
nphtdks.plqqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk

VGSEERLIRQ
   |   |||
ykeevheirq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 795-848 3e-14 47.5 In-house 104-153 (350) alignment 
Range on Protein: 795-848
Range on HMM: 104-153/350.0
FnkpqEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWPIN
|     |||||.|. .||..|.... . . . |..|   .| . |||..||.  
f....kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 926-991 4.8e-14 46.5 In-house 1-65 (69) alignment 
Range on Protein: 926-991
Range on HMM: 1-65/69.0
LVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
.|||| .| |||| |||. . .  .|. |. ||.|  |  ||. |  .|   ..|||.| ||.. |
mvvhcssgtgrtgtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 923-988 1.5e-13 45.2 In-house 262-341 (350) alignment 
Range on Protein: 923-988
Range on HMM: 262-341/350.0
SGPLVVHCGAGIGRTGVFIALDILLQ-------------ELKADERTVD-VFAVVAKMRRERCSLVQSLVQYIFLHRALA
| |..||| ||.||||....|| ||.             .|.   .| | .. .| ..|. | |.||.| |.||.. || 
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 927-991 4.1e-13 43.5 In-house 1-64 (69) alignment 
Range on Protein: 927-991
Range on HMM: 1-64/69.0
VVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
|||| .| |||| |||. . .  .|. |. ||.|  |  ||. |  .|    .|.|.| ||.. |
vvhcssGtGrtGtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 924-986 1.1e-11 39.2 In-house 229-290 (297) alignment 
Range on Protein: 924-986
Range on HMM: 229-290/297.0
GPLVVHCGAGIGRTGVFIALDILLQELKAdERTVDVFAVVAKMRRERCSLVQSLVQYIFLHRA
 .|.||| ||.||.|| .  |..|. |.  .|  || |.. ..| .|  |||.| |. .|. |
ayllvhcsaGvGrsGvvvlsdvilaklrk.kripdvaailsilreqrarlvqtleqfellyda
fn3 Fibronectin type III domain 167-238 6.6e-11 35.4 Pfam-A 6-79 (85) alignment 
Range on Protein: 167-238
Range on HMM: 6-79/85.0
LQVANFNTTSVSLAWSVP--LSVTPDGYVLTIDILSADADPAPVDIPGADTAYVVPSLLPGVEYSFTVQAYQNV
|.| . ..||..| || |   . . .|| ..    .   ..  ...|.  | .... | || ||.|.|||. ..
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 923-991 1.7e-10 34.8 In-house 265-344 (349) alignment 
Range on Protein: 923-991
Range on HMM: 265-344/349.0
SGPLVVHCGAGIGRTGVFIALDILLQ----------ELKADERTVD-VFAVVAKMRRERCSLVQSLVQYIFLHRALADFL
. .|.||| || |||||.. ||.||.           .|    . | .. .| ..|. | |.|| | |.|... ||  ..
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
fn3 Fibronectin type III domain 439-523 2e-10 33.9 Pfam-A 4-82 (85) alignment 
Range on Protein: 439-523
Range on HMM: 4-82/85.0
ENLMIVTTSASSVNVVFNVPTKPNGLITGYLISYNGMRNTAtssgnqffSDIHPNDVRVE--VPIASLDPGYVYQFSVQAVNGEGTS
||| .  ....|... .. |....| |||| . |  ....          . . .  | .  | .  | ||  |.|.||||||.|..
enlsvsevtstsltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 793-846 6.8e-09 29.5 In-house 101-154 (349) alignment 
Range on Protein: 793-846
Range on HMM: 101-154/349.0
DGFNKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLVRCIEGGKEKCDKYWP
  ..  . ||||| |.  ||..|....  .. . .. |    | . ||||.|| 
trisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
fn3 Fibronectin type III domain 345-417 7.3e-08 25.6 Pfam-A 2-78 (85) alignment 
Range on Protein: 345-417
Range on HMM: 2-78/85.0
PPGIPEPTFVDETTITIQWAHN---SGERDEYEVSYSPNGTSF--TPQTPQYViENRFVLTGLDPYTTIQFDVRTVVN
.|. .  . | .|..|..| .    .|. . ||| |.. |..   . .|     .....|||| |.|. .| |..| .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.ttsvtltgLkpgteYefrVqavng
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 791-860 2.8e-07 24.9 In-house 19-85 (130) alignment 
Range on Protein: 791-860
Range on HMM: 19-85/130.0
EFDGF-NKPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLvrcieGGKEKCDKYWPiNSDPTV-FG-KVIVT
.| |  .. .||. || |...|  .||.|. |.    .|.|     |  |. |.||| .|.|   .  ..|||
sfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywp.dsePlewyeediivt
fn3 Fibronectin type III domain 70-140 4.6e-07 23.1 Pfam-A 8-75 (85) alignment 
Range on Protein: 70-140
Range on HMM: 8-75/85.0
ASEVTSMEIVATWPRPE-GYTNVESYSISITPRTGVTydsqIPNPFTSTNDMHRAVFSSLTPAQTYVIEVTA
.||||| ... .|  |. |  ....|..   . .|       .. || ... ...... |.| ..|...|.|
vsevtstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqa
0038934 (Phosphotyrosine protein) phosphatases II 888-943 8.6e-07 24.3 In-house 81-135 (194) alignment 
Range on Protein: 888-943
Range on HMM: 81-135/194.0
QYHFISWPTHSTPRVSRPTLNFVKNIREELESpKLSGPLVVHCGAGIGRTGVFIAL
.|. . .| . |.     .|.|.. . | |.  . .|  .||| ||.||||...| 
eylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaa
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 797-852 9.6e-07 22.6 In-house 135-184 (244) alignment 
Range on Protein: 797-852
Range on HMM: 135-184/244.0
KPQEYIATQGPMSNTVHEFWRMVWEKECPAIVMLvrcieGGKEKCDKYWPiNSDPT
.  ||| || |...|  .||.|. |.    .|.|     |  |. |.||| .|.| 
rtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywp.dsepl
subfamily_PTPDC1_pd Subfamily PTPDC1 889-980 1.9e-06 22.4 In-house 85-165 (182) alignment 
Range on Protein: 889-980
Range on HMM: 85-165/182.0
YHFISWPTHSTPRVSRpTLNFVKNIREELESPKlsgpLVVHCGAGIGRTGVFIALDILLQE-LKADErtvdvfaVVAKMRRERCSLVQSLVQY
.. ..|. .... . |  |. || .   |.  |    . ||| || ||||| ||  .. .. |.|..        . ..| .| . .|.  | 
vynfgwkDygvasler.iLdivkvvafalqegk....vavhChaGlGrtGvliacylvyakrltaek.......aiklvrskrpksiqtreqv
PTEN_1 888-977 4.9e-06 21.5 In-house 96-181 (196) alignment 
Range on Protein: 888-977
Range on HMM: 96-181/196.0
QYHFISWPTHSTPRVSRpTLNFVKNIREELESPKLSGPLVVHCGAGIGRTGVFIALdILLQELKadERTVDVFAVVAKMRRERCSLVQSL
.|. .... | .|  |.  . ..|.. | | | .  .  .||| ||.||.|. .|   |..  |      . .. |...|  ..    |.
eylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa.yLmykgk..ltadeAlelvrekRppgapnspsq