Difference between revisions of "Phosphatase Family Myotubularin"
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===== [[Phosphatase_Subfamily_MTMR3|MTMR3]]===== | ===== [[Phosphatase_Subfamily_MTMR3|MTMR3]]===== | ||
| + | MTMR3 subfamily is found throughout metazoan, with a signature FYVE domain. | ||
===== [[Phosphatase_Subfamily_MTMR5|MTMR5 (SBF)]]===== | ===== [[Phosphatase_Subfamily_MTMR5|MTMR5 (SBF)]]===== | ||
Revision as of 01:25, 31 December 2014
Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin
Myotubularins are 3-phosphatases specific for PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysomal pathway . In yeast, there is a single myotubularin Ymr1p, and its functions appear to be redundant with those of other 3-phosphatases. In C. elegans, which has six myotubularins, several of the myotublarins have non-redundant roles in regulating PtdIns3P during endocytosis. In human, there are 14 myotublarins, and mutations in several of them lead to myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. Interestingly, around half of myotubularins are catalytically inactive. One of their possible function is regulating active myotubularins by protein interaction. For details, see the review [1].
Contents
Subfamilies
MTMR1
MTMR3
MTMR3 subfamily is found throughout metazoan, with a signature FYVE domain.
MTMR5 (SBF)
Inactive myotubularin subfamily.
MTMR7
MTMR9
MTMR10
MTMR14
YMR1
Yeast has a single myotubularin YMR1, encoding PI(3)P phosphatase [2].
Reference
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