Difference between revisions of "Phosphatase Subfamily MTMR14"
From PhosphataseWiki
(Created page with "__NOTOC__ Phosphatase Classification: FoldCC1: Superfamily CC1: Phosphatase_Family_...") |
(→Domain Structure) |
||
| Line 9: | Line 9: | ||
===Domain Structure=== | ===Domain Structure=== | ||
| − | MTMR14 in eumetazoan has a conserved domain combination: a PH/GRAM domain and an active phosphatase domain. It may have a coiled-coil domain, but it is much weaker compared with other myotubularins using coiled-coil detection programs [http://www.ch.embnet.org/software/COILS_form.html COILS] and [http://paircoil2.csail.mit.edu/paircoil2.html PAIRCOIL2]. Sponge MTMR14 has an additional protein kinase domain (see [http://phosphatome.net/3.0/database/gene/uid/AqueP029 | + | MTMR14 in eumetazoan has a conserved domain combination: a PH/GRAM domain and an active phosphatase domain. It may have a coiled-coil domain, but it is much weaker compared with other myotubularins using coiled-coil detection programs [http://www.ch.embnet.org/software/COILS_form.html COILS] and [http://paircoil2.csail.mit.edu/paircoil2.html PAIRCOIL2]. Sponge MTMR14 has an additional protein kinase domain (see [http://phosphatome.net/3.0/database/gene/uid/AqueP029 database]); Choanoflagellate Monosiga has a predicted transmembrane region (see [http://phosphatome.net/3.0/database/gene/uid/MbreP022 database]). |
===Catalytic activity and functions=== | ===Catalytic activity and functions=== | ||
Revision as of 17:43, 31 December 2014
Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: Subfamily MTMR14
[punch line to be added]
Evolution
MTMR14 is found in most metazoan except nematodes. It is also found in choanoflagellates and cellular slime molds, but is absent from almost all the fungi.
Domain Structure
MTMR14 in eumetazoan has a conserved domain combination: a PH/GRAM domain and an active phosphatase domain. It may have a coiled-coil domain, but it is much weaker compared with other myotubularins using coiled-coil detection programs COILS and PAIRCOIL2. Sponge MTMR14 has an additional protein kinase domain (see database); Choanoflagellate Monosiga has a predicted transmembrane region (see database).
