Difference between revisions of "Phosphatase Family HP2"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] | + | __NOTOC__ |
| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]]: [[Phosphatase_Family_HP2|Family HP, branch 2 (HP2)]] | ||
| − | The histidine phosphatase, branch 2 (HP2) family is found throughout eukaryotes. It has subfamilies | + | The histidine phosphatase, branch 2 (HP2) family is found throughout eukaryotes. It has subfamilies that are protein phosphatases, non-protein phosphatases, and pseudophosphatases. See also Pfam [http://pfam.xfam.org/family/PF00328 PF00328]. All subfamilies other than PPIP5K encode an N-terminal signal peptide or signal anchor, and many have a C-terminal transmembrane domain. One of its subfamily [[Phosphatase_Subfamily_ACP2|ACP2]] can function as tyrosine protein phosphatase. |
=== Subfamilies === | === Subfamilies === | ||
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====== [[Phosphatase_Subfamily_MINPP1|MINPP1]]: Ins5P and Ins6P phosphatase ====== | ====== [[Phosphatase_Subfamily_MINPP1|MINPP1]]: Ins5P and Ins6P phosphatase ====== | ||
| − | + | A non-protein phosphatase found in a broad of eukaryotes, including most metazoa and amoebozoa. Known substrates include InsP6 and 2,3-BPG. | |
====== [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2): xylose phosphatase ====== | ====== [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2): xylose phosphatase ====== | ||
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====== [[Phosphatase_Subfamily_ PPIP5K| PPIP5K]]: pseudophosphatase domain binding to PtdIns(3,4,5)P3 ====== | ====== [[Phosphatase_Subfamily_ PPIP5K| PPIP5K]]: pseudophosphatase domain binding to PtdIns(3,4,5)P3 ====== | ||
| − | The PPIP5K subfamily has two domains: a pseudophosphatase domain which | + | The PPIP5K subfamily has two domains: a pseudophosphatase domain which binds PtdIns(3,4,5)P3, and a kinase domain of the RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8. PPIP5K is found throughout eukaryotes; vertebrates usually have two copies per genome. |
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| + | ====== [[Phosphatase_Subfamily_cf60|Cf60]]: Pseudophosphatase ====== | ||
| + | [[Phosphatase_Subfamily_cf60|Cf60]] is a [[pseudophosphatase]] found in many amoebozoa. The ''Dictyostelium discoideum'' cf60 encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which ''Dictyostelium discoideum'' cells sense and regulate the size of groups and fruiting bodies. | ||
===References=== | ===References=== | ||
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#koike14 pmid=24425863 | #koike14 pmid=24425863 | ||
</biblio> | </biblio> | ||
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Latest revision as of 21:51, 25 October 2016
Phosphatase Classification: Fold HP: Superfamily HP: Family HP, branch 2 (HP2)
The histidine phosphatase, branch 2 (HP2) family is found throughout eukaryotes. It has subfamilies that are protein phosphatases, non-protein phosphatases, and pseudophosphatases. See also Pfam PF00328. All subfamilies other than PPIP5K encode an N-terminal signal peptide or signal anchor, and many have a C-terminal transmembrane domain. One of its subfamily ACP2 can function as tyrosine protein phosphatase.
Subfamilies
ACP2: pTyr and small molecule phosphatase
The ACP2 subfamily is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
ACP6: lysophosphatidic acid-specific phosphatase
MINPP1: Ins5P and Ins6P phosphatase
A non-protein phosphatase found in a broad of eukaryotes, including most metazoa and amoebozoa. Known substrates include InsP6 and 2,3-BPG.
PXYLP1 (ACPL2): xylose phosphatase
The PXYLP1 (ACPL2) subfamily dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [1]. It is widely found in bilateria.
PPIP5K: pseudophosphatase domain binding to PtdIns(3,4,5)P3
The PPIP5K subfamily has two domains: a pseudophosphatase domain which binds PtdIns(3,4,5)P3, and a kinase domain of the RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8. PPIP5K is found throughout eukaryotes; vertebrates usually have two copies per genome.
Cf60: Pseudophosphatase
Cf60 is a pseudophosphatase found in many amoebozoa. The Dictyostelium discoideum cf60 encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies.
References
- Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-6708. DOI:10.1074/jbc.M113.520536 |
- Zhang XQ, Lee MS, Zelivianski S, and Lin MF. Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem. 2001 Jan 26;276(4):2544-50. DOI:10.1074/jbc.M006661200 |
- Meng TC and Lin MF. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. J Biol Chem. 1998 Aug 21;273(34):22096-104. DOI:10.1074/jbc.273.34.22096 |
