Difference between revisions of "Phosphatase classification"
From PhosphataseWiki
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|bgcolor="#ffffff" rowspan="4" align="center" |Cys-based Group I|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_HMWPTP|Classic PTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr | || bgcolor="#ffffff" colspan="1" align="center"| Yes | |bgcolor="#ffffff" rowspan="4" align="center" |Cys-based Group I|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_HMWPTP|Classic PTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr | || bgcolor="#ffffff" colspan="1" align="center"| Yes | ||
|- | |- | ||
| − | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_DSP_PTEN|DSP and PTEN]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pSer/pThr, lipid | + | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_DSP_PTEN|DSP and PTEN]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pSer/pThr, lipid | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_Myotubularin|Myotubularin]]|| bgcolor="#ffffff" colspan="1" align="center"| lipid | + | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_Myotubularin|Myotubularin]]|| bgcolor="#ffffff" colspan="1" align="center"| lipid | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_OCA|OCA]]|| bgcolor="#ffffff" colspan="1" align="center"| ? | + | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_OCA|OCA]]|| bgcolor="#ffffff" colspan="1" align="center"| ? | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
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| − | |bgcolor="#ffffff" rowspan="1" align="center" |Cys-based Group II|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_CDC25|CDC25]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pThr | + | |bgcolor="#ffffff" rowspan="1" align="center" |Cys-based Group II|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_CDC25|CDC25]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pThr | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="2" align="center" |[[Phosphatase_Superfamily_Cys-based_III|Cys-based Group III]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_LMWPTP|LMWPTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr | + | |bgcolor="#ffffff" rowspan="2" align="center" |[[Phosphatase_Superfamily_Cys-based_III|Cys-based Group III]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_LMWPTP|LMWPTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_SSU72|SSU72]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer | + | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_SSU72|SSU72]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="4" align="center" |[[Phosphatase_Group_HAD|HAD]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_EYA|EYA]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr | + | |bgcolor="#ffffff" rowspan="4" align="center" |[[Phosphatase_Group_HAD|HAD]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_EYA|EYA]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_FCP|FCP]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer | + | |bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_FCP|FCP]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_NagD|NagD]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pSer | + | |bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_NagD|NagD]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pSer | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_MDP1|MDP1]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr? | + | |bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_MDP1|MDP1]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr? | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer/pThr | + | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer/pThr | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPM|PPM]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PPM|PPM]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer/pThr | + | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPM|PPM]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PPM|PPM]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer/pThr | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center"| pHis | + | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center"| pHis | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="1" align="center" |PHP|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_Rtr1|RTR1]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer | + | |bgcolor="#ffffff" rowspan="1" align="center" |PHP|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_Rtr1|RTR1]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer | || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|} | |} | ||
Revision as of 03:24, 1 May 2014
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart
| Group | Family | Substrate | Present in human |
|---|---|---|---|
| Cys-based Group I | Classic PTP | pTyr | | Yes |
| DSP and PTEN | pTyr, pSer/pThr, lipid | | Yes | |
| Myotubularin | lipid | | Yes | |
| OCA | ? | | Yes | |
| Cys-based Group II | CDC25 | pTyr, pThr | | Yes |
| Cys-based Group III | LMWPTP | pTyr | | Yes |
| SSU72 | pSer | | Yes | |
| HAD | EYA | pTyr | | Yes |
| FCP | pSer | | Yes | |
| NagD | pTyr, pSer | | Yes | |
| MDP1 | pTyr? | | Yes | |
| PPP | PPP | pSer/pThr | | Yes |
| PPM | PPM | pSer/pThr | | Yes |
| PHP | PHP | pHis | | Yes |
| PHP | RTR1 | pSer | | Yes |
