Difference between revisions of "Phosphatase Family HP2"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP2|Family HP, branch 2]] | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP2|Family HP, branch 2 (HP2)]] |
Refer to Pfam ID [http://pfam.xfam.org/family/PF00328 PF00328] for general information. | Refer to Pfam ID [http://pfam.xfam.org/family/PF00328 PF00328] for general information. | ||
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=== Subfamilies === | === Subfamilies === | ||
| − | + | * [[Phosphatase_Subfamily_ACP2|ACP2]] is a '''protein phosphatase''' subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists. | |
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| − | + | * [[Phosphatase_Subfamily_ACP6|ACP6]] | |
| − | + | * [[Phosphatase_Subfamily_MINPP1|MINPP1]] is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG. | |
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| − | + | * [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2) dephosphorylates [http://en.wikipedia.org/wiki/Xylose xylose], a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans <cite>koike14</cite>. It is widely found in bilateria. | |
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| − | + | * [[Phosphatase_Subfamily_ PPIP5K| PPIP5K]] has a pseudophosphatase domain which bind to PtdIns(3,4,5)P3. It also has a kinase domain of RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8. | |
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| − | + | * [[Phosphatase_Subfamily_cf60|Cf60]] is cellular slime mold specific '''pseudophosphatase'''. It encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using. | |
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===References=== | ===References=== | ||
Revision as of 19:42, 30 May 2015
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2 (HP2)
Refer to Pfam ID PF00328 for general information.
Subfamilies
- ACP2 is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
- MINPP1 is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
- PXYLP1 (ACPL2) dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [1]. It is widely found in bilateria.
- PPIP5K has a pseudophosphatase domain which bind to PtdIns(3,4,5)P3. It also has a kinase domain of RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8.
- Cf60 is cellular slime mold specific pseudophosphatase. It encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using.
References
- Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-6708. DOI:10.1074/jbc.M113.520536 |
- Zhang XQ, Lee MS, Zelivianski S, and Lin MF. Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem. 2001 Jan 26;276(4):2544-50. DOI:10.1074/jbc.M006661200 |
- Meng TC and Lin MF. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. J Biol Chem. 1998 Aug 21;273(34):22096-104. DOI:10.1074/jbc.273.34.22096 |
