Difference between revisions of "Phosphatase Family Myotubularin"
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===== [[Phosphatase_Subfamily_MTMR1|MTMR1]] ===== | ===== [[Phosphatase_Subfamily_MTMR1|MTMR1]] ===== | ||
MTMR1 is a lipid phosphatase that dephosphorylates the second messenger phosphatidylinositol 3-monophosphate [PI(3)P]. It is found across holozoan. | MTMR1 is a lipid phosphatase that dephosphorylates the second messenger phosphatidylinositol 3-monophosphate [PI(3)P]. It is found across holozoan. | ||
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===== [[Phosphatase_Subfamily_MTMR5|MTMR5]] (SBF)===== | ===== [[Phosphatase_Subfamily_MTMR5|MTMR5]] (SBF)===== | ||
| − | MTMR5 is a subfamily of inactive phosphatase (pseudophosphatase) conserved in metazoan. It regulates the active | + | MTMR5 is a subfamily of inactive phosphatase (pseudophosphatase) conserved in metazoan. It regulates the active [[Phosphatase_Subfamily_MTMR1|MTMR1]] subfamily by protein interactions. |
===== [[Phosphatase_Subfamily_MTMR6|MTMR6]]===== | ===== [[Phosphatase_Subfamily_MTMR6|MTMR6]]===== | ||
===== [[Phosphatase_Subfamily_MTMR9|MTMR9]]===== | ===== [[Phosphatase_Subfamily_MTMR9|MTMR9]]===== | ||
| − | MTMR9 is a conserved pseudophosphatase across holozoan. It regulates active phosphatases of subfamily | + | MTMR9 is a conserved pseudophosphatase across holozoan. It regulates active phosphatases of subfamily [[Phosphatase_Subfamily_MTMR6|MTMR6]]. |
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| + | ===== [[Phosphatase_Subfamily_MTMR3|MTMR3]]===== | ||
| + | MTMR3 is an inositol lipid 3-phosphatase. It is probably a protein phosphatase of receptor-regulated SMAD. It is found throughout metazoan, with a signature FYVE domain. | ||
===== [[Phosphatase_Subfamily_MTMR14|MTMR14]]===== | ===== [[Phosphatase_Subfamily_MTMR14|MTMR14]]===== | ||
MTMR14 is an active phosphatase found in most holozoan and slime molds. Its putative substrates are phosphatidylinositol bisphophosphates PtdIns(3,5)P2 and PtdIns (3,4)P2. | MTMR14 is an active phosphatase found in most holozoan and slime molds. Its putative substrates are phosphatidylinositol bisphophosphates PtdIns(3,5)P2 and PtdIns (3,4)P2. | ||
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| + | ===== [[Phosphatase_Subfamily_MTMR10|MTMR10]]===== | ||
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===== YMR1===== | ===== YMR1===== | ||
Revision as of 18:41, 31 December 2014
Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin
Contents
Subfamilies
MTMR1
MTMR1 is a lipid phosphatase that dephosphorylates the second messenger phosphatidylinositol 3-monophosphate [PI(3)P]. It is found across holozoan.
MTMR5 (SBF)
MTMR5 is a subfamily of inactive phosphatase (pseudophosphatase) conserved in metazoan. It regulates the active MTMR1 subfamily by protein interactions.
MTMR6
MTMR9
MTMR9 is a conserved pseudophosphatase across holozoan. It regulates active phosphatases of subfamily MTMR6.
MTMR3
MTMR3 is an inositol lipid 3-phosphatase. It is probably a protein phosphatase of receptor-regulated SMAD. It is found throughout metazoan, with a signature FYVE domain.
MTMR14
MTMR14 is an active phosphatase found in most holozoan and slime molds. Its putative substrates are phosphatidylinositol bisphophosphates PtdIns(3,5)P2 and PtdIns (3,4)P2.
MTMR10
YMR1
Yeast has a single myotubularin YMR1, encoding PI(3)P phosphatase [1].
Reference
- Taylor GS, Maehama T, and Dixon JE. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5. DOI:10.1073/pnas.160255697 |
- Robinson FL and Dixon JE. Myotubularin phosphatases: policing 3-phosphoinositides. Trends Cell Biol. 2006 Aug;16(8):403-12. DOI:10.1016/j.tcb.2006.06.001 |
