Difference between revisions of "Phosphatase Family Myotubularin"
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== Subfamilies == | == Subfamilies == | ||
| − | ===== [[Phosphatase_Subfamily_MTMR1|MTMR1]]===== | + | ===== [[Phosphatase_Subfamily_MTMR1|MTMR1]] ===== |
| − | ===== MTMR3 | + | ===== [[Phosphatase_Subfamily_MTMR3|MTMR3]]===== |
| − | ===== MTMR5 | + | ===== [[Phosphatase_Subfamily_MTMR5|MTMR5 (SBF)]]===== |
Inactive myotubularin subfamily. | Inactive myotubularin subfamily. | ||
| − | ===== | + | ===== [[Phosphatase_Subfamily_MTMR7|MTMR7]]===== |
| − | ===== MTMR9 | + | ===== [[Phosphatase_Subfamily_MTMR9|MTMR9]]===== |
| − | ===== MTMR10 | + | ===== [[Phosphatase_Subfamily_MTMR10|MTMR10]]===== |
| − | ===== MTMR14 | + | ===== [[Phosphatase_Subfamily_MTMR14|MTMR14]]===== |
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
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== Reference == | == Reference == | ||
Revision as of 16:37, 30 December 2014
Phosphatase Classification: FoldCC1: Superfamily CC1: Myotubularin
Myotubularins are 3-phosphatases specific for PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysomal pathway . In yeast, there is a single myotubularin Ymr1p, and its functions appear to be redundant with those of other 3-phosphatases. In C. elegans, which has six myotubularins, several of the myotublarins have non-redundant roles in regulating PtdIns3P during endocytosis. In human, there are 14 myotublarins, and mutations in several of them lead to myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. Interestingly, around half of myotubularins are catalytically inactive. One of their possible function is regulating active myotubularins by protein interaction. For details, see the review [1].
Contents
Subfamilies
MTMR1
MTMR3
MTMR5 (SBF)
Inactive myotubularin subfamily.
