Phosphatase Family HP2
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2 (HP2)
The histidine phosphatase, branch 2 (HP2) family is found throughout eukaryotes. It has subfamilies of protein phosphatases, non-protein phosphatases and pseudophosphatases. See also Pfam PF00328. All subfamilies other than PPIP5K encode an N-terminal signal peptide or signal anchor, and many have a C-terminal transmembrane domain.
Contents
Subfamilies
ACP2: protein phosphatase
The ACP2 subfamily is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
ACP6: lysophosphatidic acid-specific phosphatase
MINPP1: Ins5P and Ins6P phosphatase
The MINPP1 subfamily is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
PXYLP1 (ACPL2): xylose phosphatase
The PXYLP1 (ACPL2) subfamily dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [1]. It is widely found in bilateria.
PPIP5K: pseudophosphatase domain binding to PtdIns(3,4,5)P3
The PPIP5K subfamily has two domains: a pseudophosphatase domain which bind to PtdIns(3,4,5)P3, and a kinase domain of RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8. PPIP5K is found throughout eukaryotes; vertebrates usually have two copies per genome.
Unclassified HP2
Cf60 is a pseudophosphatase found in many amoebozoa. The Dictyostelium discoideum cf60 encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using.
References
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