Phosphatase Family Myotubularin
Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin
Contents
Subfamilies
MTMR1
MTMR1 is a lipid phosphatase that dephosphorylates the second messenger phosphatidylinositol 3-monophosphate [PI(3)P]. It is found across holozoan.
MTMR5 (SBF)
MTMR5 is a subfamily of pseudophosphatase conserved in metazoan. It regulates the active MTMR1 subfamily by protein interactions.
MTMR6
MTMR6 is a phosphoinositide phosphatase found in holozoan. Its enzymatic activity is regulated by MTMR9.
MTMR9
MTMR9 is a conserved pseudophosphatase across holozoan. It regulates active phosphatases of subfamily MTMR6.
MTMR3
MTMR3 is an inositol lipid 3-phosphatase. It is probably a protein phosphatase of receptor-regulated SMAD. It is found throughout metazoan, with a signature FYVE domain.
MTMR14
MTMR14 is an active phosphatase found in most holozoan and slime molds. Its putative substrates are phosphatidylinositol bisphophosphates PtdIns(3,5)P2 and PtdIns (3,4)P2.
MTMR10
YMR1
Yeast has a single myotubularin YMR1, encoding PI(3)P phosphatase [1].
Reference
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