Phosphatase Family HP2
From PhosphataseWiki
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2 (HP2)
Refer to Pfam ID PF00328 for general information.
Subfamilies
- ACP2 is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
- MINPP1 is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
- PXYLP1 (ACPL2) dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [1]. It is widely found in bilateria.
- PPIP5K has a pseudophosphatase domain which bind to PtdIns(3,4,5)P3. It also has a kinase domain of RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8. PPIP5K is found throughout eukaryotes; vertebrates usually have two copies per genome.
- Cf60 is cellular slime mold specific pseudophosphatase. It encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using.
References
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