Phosphatase Subfamily MTMR10
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Myotubularin: Subfamily MTMR10
MTMR10 is a conserved pseudophosphatase in metazoa. Its molecular function is unclear.
Evolution
MTMR10 is found in most metazoa.
Domain Structure
MTMR10 subfamily has three domains: PH/GRAM, phosphatase domain and coiled-coil domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.
Sponge has three MTMR10s. Two of them have Death domain and DUF3584 domain. Death domain binds each other forming oligomers. DUF3584 is close to AAA+ superfamily. However, the domain combination is dubious, because it is not found in other organisms.
Catalytic activity and functions
MTMR10 is an inactive phosphatase (pseudophosphatase), but its function is unclear. Other pseudophosphatases within myotubularin family (Subfamily MTMR5 and Subfamily MTMR9) regulate active myotubularins via protein interactions mediated by coiled coils. It interacts with MTM1 and MTMR1 of MTMR1 subfamily [1].
References
- Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, and Mitchell CA. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8660-5. DOI:10.1073/pnas.1033097100 |
