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Welcome to Phosphatase Wikepedia, a resource for of phosphatases and phosphatase signaling. This is a pilot project for sharing and publication of discoveries that do not fit into traditional publications or haven't yet been polished for publication. Initial content is mostly from the Manning lab at Salk, but we welcome anyone who would like to contribute. Like other wiki's, just go to the login page to request an account.


Introduction to Phosphatases

Phosphatase Classification

Of the hundreds of phosphatases in the genome, how are they organized and classified?

Pending (the hybrid scheme of classification; alternative schemes: PTP and Ser/Thr phosphatase by substrate).

Classification Chart

Group Family Substrate
Cys-based Group I Classic PTP pTyr
DSP and PTEN pTyr, pSer/pThr, lipid
Myotubularin lipid
OCA  ?
Cys-based Group II CDC25 pTyr, pThr
Cys-based Group III LMWPTP pTyr
SSU72 pSer
HAD EYA pTyr
FCP pSer
NagD pTyr, pSer
MDP1 pTyr?
PPP PPP pSer/pThr
PPM (PP2C) PPM (PP2C) pSer/pThr
PHP PHP pHis
PHP RTR1 pSer

Other Classification Schemes

Other phosphatases

Protein Phosphatase Evolution

Where did they all come from, and how did they get to where they are today?

Topics

Phosphorylation of RNA polymerase II C-terminal domain

The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA-processing and histone-modifying factors. This complex phosphorylation patterns are regulated by quite a few phosphatases and kinases.

Phosphatase-Substrate-Kinase Network

The network is based upon biological knowledge. Six types of relationship between phosphatases and kinases are recorded: 1) they work on the same substrate, 2) phosphatase dephosphorylates kinase, 3) kinase phosphorylates phosphatase, 4) binding but no reported (de)phosphorylated interaction, 5) functional relationship, but not direct interaction, and 6) no relationship.

Dephosphorylation on unusual amino acids

Unusual evidence for phosphorylation on histidine, aspartate, cysteine, lysine, and arginine.