Difference between revisions of "Phosphatase Family HP2"

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(Unclassified and/or plausible subfamilies)
(MINPP1)
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====== [[Phosphatase_Subfamily_ACP6|ACP6]] ======
 
====== [[Phosphatase_Subfamily_ACP6|ACP6]] ======
  
====== [[Phosphatase_Subfamily_MINPP1|MINPP1]] ======
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====== [[Phosphatase_Subfamily_MINPP1|MINPP1]]: Ins5P and Ins6P phosphatase ======
 
The MINPP1 subfamily is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
 
The MINPP1 subfamily is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
  

Revision as of 21:39, 2 June 2015

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2 (HP2)

The histidine phosphatase, branch 2 (HP2) family is found throughout eukaryotes. It has subfamilies of protein phosphatases, non-protein phosphatases and pseudophosphatases. See also Pfam PF00328. All subfamilies other than PPIP5K encode an N-terminal signal peptide or signal anchor, and many have a C-terminal transmembrane domain.

Subfamilies

ACP2: protein phosphatase

The ACP2 subfamily is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.

ACP6
MINPP1: Ins5P and Ins6P phosphatase

The MINPP1 subfamily is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.

PXYLP1 (ACPL2): xylose phosphatase

The PXYLP1 (ACPL2) subfamily dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [1]. It is widely found in bilateria.

PPIP5K: pseudophosphatase domain binding to PtdIns(3,4,5)P3

The PPIP5K subfamily has two domains: a pseudophosphatase domain which bind to PtdIns(3,4,5)P3, and a kinase domain of RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8. PPIP5K is found throughout eukaryotes; vertebrates usually have two copies per genome.

Unclassified HP2

Cf60 is a pseudophosphatase found in many amoebozoa. The Dictyostelium discoideum cf60 encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using.

References

  1. Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-6708. DOI:10.1074/jbc.M113.520536 | PubMed ID:24425863 | HubMed [koike14]
  2. Zhang XQ, Lee MS, Zelivianski S, and Lin MF. Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem. 2001 Jan 26;276(4):2544-50. DOI:10.1074/jbc.M006661200 | PubMed ID:11067847 | HubMed [ACPP_1]
  3. Meng TC and Lin MF. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. J Biol Chem. 1998 Aug 21;273(34):22096-104. DOI:10.1074/jbc.273.34.22096 | PubMed ID:9705354 | HubMed [ACPP_2]
All Medline abstracts: PubMed | HubMed