Phosphatase Subfamily MTMR14

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Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: Subfamily MTMR14

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Evolution

MTMR14 is found in most metazoan except nematodes. It is also found in choanoflagellates and cellular slime molds, but is absent from almost all the fungi.

Domain Structure

MTMR14 in eumetazoan has a conserved domain combination: a PH/GRAM domain and an active phosphatase domain. It may have a coiled-coil domain, but it is much weaker compared with other myotubularins using coiled-coil detection programs COILS and PAIRCOIL2. Sponge MTMR14 has an additional protein kinase domain (see phosphatome.net database); Choanoflagellate Monosiga has a predicted transmembrane region (see phosphatome.net database).

Catalytic activity and functions

References

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