Phosphatase classification

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Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Classification Chart

Group Family Substrate Present in human
Cys-based Group I Classic PTP pTyr | Yes
DSP and PTEN pTyr, pSer/pThr, lipid
Myotubularin lipid
OCA  ?
Cys-based Group II CDC25 pTyr, pThr
Cys-based Group III LMWPTP pTyr
SSU72 pSer
HAD EYA pTyr
FCP pSer
NagD pTyr, pSer
MDP1 pTyr?
PPP PPP pSer/pThr
PPM PPM pSer/pThr
PHP PHP pHis
PHP RTR1 pSer

Other Classification Schemes

Other phosphatases