Phosphatase classification

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Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Classification Chart

Group Family Substrate Present in human
Cys-based Group I Classic PTP pTyr Yes
DSP and PTEN pTyr, pSer/pThr, lipid Yes
Myotubularin lipid Yes
OCA  ? Yes
Cys-based Group II CDC25 pTyr, pThr Yes
Cys-based Group III LMWPTP pTyr Yes
SSU72 pSer Yes
HAD EYA pTyr Yes
FCP pSer Yes
NagD pTyr, pSer Yes
MDP1 pTyr? Yes
PPP PPP pSer/pThr Yes
PPM PPM pSer/pThr Yes
PHP PHP pHis Yes
PHP RTR1 pSer Yes

Other Classification Schemes

Other phosphatases