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  • Phosphatase Subfamily PTPN1
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]] The PTPN1 subfamily dephoshorylates kinases of various families, including Insulin receptor kin
    3 KB (337 words) - 16:06, 22 June 2015
  • Phosphatase Subfamily PTPRA
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRA|Subfamily PTPRA]] PTPRA is a deuterostome-specific receptor PTP subfamily.
    4 KB (553 words) - 18:53, 22 December 2016
  • Phosphatase Subfamily PTPRC
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRC|Subfamily PTPRC]] PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-te
    1 KB (201 words) - 23:40, 13 April 2017
  • Phosphatase Family PTP
    [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfam ...amilies. This subfamily is known as High Molecular Weight Protein Tyrosine Phosphatase (HMWPTP) in the [http://scop.berkeley.edu/sunid=52805 SCOP database]. Compa
    10 KB (1,429 words) - 17:35, 4 May 2018
  • Phosphatases and Diseases
    Table of phosphatase disease associations, taken from our 2017 phosphatome publication <cite>Che | Gene Symbol || Entrez Gene ID || Fold || Family || Subfamily || Hamosh et al. (2005) - OMIM || Landrum et al. (2014) - ClinVar || Yip et
    14 KB (1,612 words) - 16:05, 13 April 2017
  • Phosphatase Subfamily Ptp69D
    ...]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_Ptp69D|Subfamily Ptp69D]] ...st in vertebrates, though the vertebrate PTPRA family is highly similar in phosphatase domain sequence to PTP69D.
    1 KB (161 words) - 16:41, 29 May 2015
  • Phosphatase Subfamily PTPRG
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRG|Subfamily PTPRG]] The phosphatase activity is modulated by the ligands binding to extracellular region <cite>
    2 KB (334 words) - 05:52, 2 April 2017
  • Phosphatase Subfamily PTPN14
    ...1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN14|Subfamily PTPN14]] PTPN14 is a cytoskeleton-associated phosphatase involved in cell migration and adhesion, EGFR signaling and regulation of t
    4 KB (519 words) - 02:46, 7 September 2016
  • Phosphatase Gene PTPN1
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]]: [[Phosphatase_Gene_PTPN1|Gene PTPN1]] See evolution section on page of [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]].
    993 B (123 words) - 21:16, 17 December 2014
  • Phosphatase Subfamily PTPMT1
    ...1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_PTPMT1|Subfamily PTPMT1]] PTPMT1 has a single domain: phosphatase domain. It has a mitochondria-targeting sequence on N-terminus.
    2 KB (246 words) - 05:12, 27 February 2015
  • Phosphatase Subfamily PTPN23
    ...1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN23|Subfamily PTPN23]] (HD-PTP) ...in. Fungi also have a likely ortholog (Bro1 in S. cerevisiae) that lacks a phosphatase domain, but retains the BRO1 and ALIX_LYPXL_bnd domains.
    8 KB (975 words) - 07:59, 24 July 2017
  • Phosphatase Subfamily PTPRD
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRD|Subfamily PTPRD]] All three human PTPRDs have twin intracellular PTP phosphatase domains, and extracellular Ig domains and FN3 domains. Each of them have mu
    7 KB (966 words) - 21:42, 21 December 2016
  • Pseudophosphatases (obsolete)
    ==== Second phosphatase domains of receptor PTPs ==== ...city, and dimerization <cite>denHertog02, Barr09</cite>. Because the first phosphatase domains are active, these receptor PTPs are active at protein level. These
    6 KB (818 words) - 00:36, 14 April 2017
  • Phosphatase Subfamily PTPN12
    ...1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN12|Subfamily PTPN12]] ...in-containing proteins. The region of 301-320 in PTPN22 interacts with its phosphatase domain and reduces its catalytic activity <cite>Liu09</cite>.
    19 KB (2,489 words) - 03:16, 16 May 2016
  • Phosphatase Subfamily PTPRK
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRK|Subfamily PTPRK]] PTPRK is a chordate-specific subfamily that regulates cell-cell adhesion. It is involved in human cancer and in th
    9 KB (1,280 words) - 02:30, 10 November 2016
  • Phosphatase Subfamily PTPRB
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRB|Subfamily PTPRB]] PTPRB (aka R3) is a metazoan-specific subfamily of receptor PTPs, with diverse functions.
    16 KB (2,151 words) - 23:52, 4 April 2017
  • Phosphatase Subfamily PTPRN
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRC|Subfamily PTPRN]] PTPRN is a receptor lipid phosphatase family involved in secretion in neuronal and endocrine tissues, including i
    6 KB (885 words) - 17:24, 2 April 2017
  • Pseudophosphatases
    ...atase_Subfamily_CDC14|CDC14]] subfamily, where CDC14A and CDC14B have dual phosphatase domains, with the first being a pseudophosphatase. ... |STYXL1]], and a single member of the [[Phosphatase_Subfamily_DSP3|DSP3]] subfamily, DUSP27.
    5 KB (688 words) - 00:38, 14 April 2017
  • Phosphatase Subfamily PTPN3
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN3|Subfamily PTPN3]] The PTPN3 subfamily emerged in holozoa and duplicated in vertebrates. Human has two members, PT
    4 KB (562 words) - 08:12, 26 July 2017
  • Phosphatase Subfamily PTPN5 RR
    ...]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN5_RR|Subfamily PTPN5_RR]] PTPN5_RR is a tyrosine-specific phosphatase subfamily that regulates ERK signaling. Uniquely, some members are non-receptors, whi
    13 KB (1,701 words) - 04:23, 3 April 2017
  • Phosphatase Subfamily PTPN13
    ...1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN13|Subfamily PTPN13]] (FAP-1/PTP1E/PTPL1/PTP-BAS) PTPN13 typically has a FERM domain followed by five PDZ domains and a PTP phosphatase domain. The earliest form, in Monosiga, has 7 PDZ domains.
    12 KB (1,591 words) - 20:29, 23 March 2017
  • Protein Domain
    ! Human protein phosphatase (PP) number ! PP subfamily
    8 KB (1,180 words) - 17:51, 11 September 2015
  • Phosphatase Subfamily PTPN9
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN9|Subfamily PTPN9]] (MEG2/PTPMEG2) PTPN9 (MEG2) is a non-receptor tyrosine phosphatase involved in vesicle fusion in the secretory pathway.
    3 KB (346 words) - 17:54, 16 March 2017
  • Phosphatase Subfamily PTPN6
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN6|Subfamily PTPN6]] (SHP/SHIP/csw/Corkscrew) The PTPN6 subfamily is found across holozoa. It is a single copy in most invertebrate genomes a
    5 KB (641 words) - 20:36, 7 January 2017
  • Phosphatase Subfamily NvecPTP-sf2
    ...[[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_NvecPTP-sf2|Subfamily NvecPTP-sf2]] NvecPTP-sf2 is a receptor tyrosine phosphatase subfamily first seen in the sea anemone, Nematostella
    914 B (118 words) - 05:25, 13 March 2016
  • Phosphatase Subamily Paladin
    ...osphatase_Family_Paladin|Family Paladin]]: [[Phosphatase_Subfamily_Paladin|Subfamily Paladin]] Paladins have two CC1 phosphatase domains similar to each other in sequence. They are similar to bacterial cy
    3 KB (414 words) - 23:05, 21 December 2016
  • Technical Note PTPN14
    ...1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN14|Subfamily PTPN14]] ====PTPN14 subfamily technical notes====
    1,023 B (145 words) - 03:31, 18 May 2016
  • Phosphatase Subfamily eak
    ... CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_eak|Subfamily Eak]] The eak subfamily is nematode specific. ''C. elegans'' has two members eak-6 and sdf-9 (eak-5
    925 B (122 words) - 17:12, 29 May 2015
  • Phosphatase Subfamily egg
    ... CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_egg|Subfamily Egg]] The egg subfamily is nematode specific. ''C. elegans'' has three members: egg-3, egg-4, egg-5
    1 KB (166 words) - 21:29, 7 September 2016
  • Phosphatase Subfamily Fungi-PTP2
    ... [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_Fungi-PTP2|Subfamily Fungi-PTP2]]
    717 B (89 words) - 05:22, 26 June 2015
  • HMM
    We use HMMs to detect phosphatase domains and accessory domains. We benefit from the HMMs in public database == HMMs for Determining the Boundaries of Protein Phosphatase Domain ==
    7 KB (1,042 words) - 18:26, 15 March 2017
  • Phosphatase Subfamily PPPRK TN
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRK|Subfamily PTPRK]] (R2B): Technical notes This putative new subfamily is found in molluscs, and has a extracellular region with a Kringle domain,
    2 KB (309 words) - 02:27, 10 November 2016
  • Phosphatase Subfamily PTPRG Functions
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRG|Subfamily PTPRG]] - Functions The phosphatase activity is modulated by the ligands binding to extracellular region <cite>
    2 KB (206 words) - 17:11, 14 September 2015
  • Phosphatase Subfamily PTPRG Tech Note
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRG|Subfamily PTPRG]]: [[Phosphatase_Subfamily_PTPRG_Tech_Note|Technical notes]] ...invertebrates, all of the hits have a single CA domain, rather than fn3 or phosphatase domain found in PTPRG. We found CA-containing PTPRG in almost all vertebrat
    997 B (143 words) - 18:15, 14 October 2015
  • Phosphatase Subfamily PTPRN Tech Note
    ...C1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRN|Subfamily PTPRN]]: [[Phosphatase_Subfamily_PTPRN_Tech_Note|Technical notes]]
    2 KB (247 words) - 02:16, 4 January 2016
  • Phosphatase Subfamily Ptp36E
    ...]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_Ptp36E|Subfamily Ptp36E]] (CG7180) The Ptp36E subfamily is found in ecdysozoa.
    945 B (120 words) - 23:05, 9 September 2016
  • Phosphatase Subfamily SpurPTP-sf1
    ...[[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_SpurPTP-sf1|Subfamily SpurPTP-sf1]] SpurPTP-sf1 is a receptor tyrosine phosphatase subfamily first seen in the sea urchin Strongylocentrotus purpuratus.
    1 KB (135 words) - 16:43, 16 March 2016
  • Phosphatase Subfamily SpurPTP-sf4
    ...[[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_SpurPTP-sf4|Subfamily SpurPTP-sf4]] SpurPTP-sf4 is a receptor tyrosine phosphatase subfamily first seen in the sea urchin Strongylocentrotus purpuratus.
    820 B (106 words) - 02:28, 10 November 2016
  • Phosphatase Subfamily SpurPTP-sf3
    ...[[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_SpurPTP-sf3|Subfamily SpurPTP-sf3]] SpurPTP-sf3 is a receptor tyrosine phosphatase subfamily first seen in the sea urchin Strongylocentrotus purpuratus.
    757 B (96 words) - 01:13, 17 March 2016
  • Phosphatase Subfamily MbrePTP-sf1
    ...[[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_MbrePTP-sf1|Subfamily MbrePTP-sf1]] MbrePTP-sf1 is a tyrosine phosphatase subfamily first seen in choanoflagellates.
    879 B (109 words) - 20:56, 24 March 2016
  • Phosphatase Subfamily CG42327
    ... [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_ CG42327 |Subfamily CG42327]] ...11223.1. The Monosiga putative ortholog has a PDZ domain C-terminal to the phosphatase domain but not signal peptide or TM region, and it's close orthologs in S.
    2 KB (204 words) - 02:37, 20 December 2016
  • Phosphatase Subfamily NvecPTP-sf6
    ...[[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_NvecPTP-sf6|Subfamily NvecPTP-sf6]] NvecPTP-sf6 is a receptor tyrosine phosphatase subfamily first seen in the sea anemone, Nematostella vectenesis
    1 KB (145 words) - 21:17, 21 December 2016
  • Phosphatase Subfamily CelePTP-sf11
    [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosph This subfamily consists of three annotated members in C. elegans. F20B6.6 and F20B6.1 are
    581 B (77 words) - 20:27, 8 March 2017

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